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Id: 732597 LILACS-Express
Autor: Monte, Tainá CC; Gentile, Rosana; Garcia, Juberlan; Mota, Ester; Santos, Jeannie N; Maldonado Júnior, Arnaldo.
Título: Brazilian Angiostrongylus cantonensis haplotypes, ac8 and ac9, have two different biological and morphological profiles
Fonte: Mem. Inst. Oswaldo Cruz;109(8):1063-1063, 12/2014. tab, graf.
Idioma: en.
Projeto: FAPERJ. E-100.525/2013.
Resumo: Angiostrongylus cantonensis is the etiologic agent of eosinophilic meningoencephalitis in humans. Cases have been recorded in many parts of the world, including Brazil. The aim of this study was to compare the differences in the biology and morphology of two different Brazilian haplotypes of A. : ac8 and ac9. A significantly larger number of L1 larvae eliminated in the faeces of rodents at the beginning of the patent period was observed for ac9 haplotype and compared to the total of L1 larvae eliminated, there was a significant difference between the two haplotypes. The ac9 haplotype showed a significant difference in the proportion of female and male specimens (0.6:1), but the same was not observed for ac8 (1.2:1). The morphometric analysis showed that male and female specimens isolated from ac8 haplotype were significantly larger with respect to body length, oesophagus length, spicule length (male) and distance from the anus to the rear end (female) compared to specimens from ac9. The morphological analysis by light microscopy showed little variation in the level of bifurcations at the lateral rays in the right lobe of the copulatory bursa between the two haplotypes. The biological, morphological and morphometric variations observed between the two haplotypes agree with the observed variation at the molecular level using the cytochrome oxidase subunit I marker and reinforce the possible influence of geographical isolation on the development of these haplotypes.(AU)
Responsável: BR1.1 - BIREME


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Id: 731938 LILACS-Express
Autor: Conde Forcada, Carlos; Ferrer Tan, Ismael J; de la Peña Hechavarría, Manuel Saínz; Ferrer Herrera, Ismael M.
Título: COMPORTAMIENTO CLÍNICO-EPIDEMIOLÓGICO DE LA MALARIA CEREBRAL EN LA UNIDAD DE CUIDADOS INTENSIVOS / Clinical-epidemiological behaviour of the cerebral malaria in the intensive care unit
Fonte: Arch. méd. Camaguey;11(6):0-0, nov.-dic. 2007.
Idioma: es.
Resumo: Se realizó un estudio descriptivo transversal sobre el comportamiento clínico-epidemiológico de la malaria cerebral en 79 pacientes ingresados en la Unidad de Cuidados Intensivos del Hospital Reina Victoria de Banjul, Gambia, desde enero a septiembre de 2006. Se estudiaron las variables grupos de edades, sexo, manifestaciones clínicas neurológicas, estados patológicos asociados y signos de mal pronóstico. Correspondieron al sexo femenino (56.9 %) y al grupo de edades de 15 a 29 años (43.03 %) los mayores porcentajes. El síntoma neurológico más común fue el deterioro de la conciencia (75.9 %) y el signo de mal pronóstico el coma profundo (60.7 %); la meningoencefalitis bacteriana (29.1%) y la neumonía nosocomial (25.3 %) constituyeron los procesos patológicos más asociados. La letalidad fue del 48.1%. Se concluyó que la letalidad fue elevada y se asociaron a esta, el coma profundo conjuntamente con las convulsiones recidivantes, la oligoanuria y el íctero, por lo que se requiere de protocolos actualizados de actuación, que conduzcan a la reducción de la mortalidad.(AU)

A cross-sectional descriptive study on clinical-epidemiological behavior of the cerebral malaria in 79 patients admitted in the Intensive Care Unit at Victoria Reina Hospital in Banjul, Gambia, from January to September 2006. The variables age groups, sex, neurological clinical manifestations, associated pathological states and signs of poor prognosis were studied. The (56.9%) were females and the age groups between 15 to 29 years (43.03%) the greater percentages. The most common neurological symptom was the deterioration of the consciousness (75.9%) and the sign of poor prognosis deep coma (60.7%); the bacterial meningoencephalitis (29.1%) and the nosocomial pneumonia (25.3%) constituted the most associated pathological processes. Deadliness was about the 48.1%. It was concluded that deadliness was high and were associated with it, deep coma jointly with recurrent convulsions, oligoanuria and jaundice, for which is required updated protocols of action that conduct to reduction of mortality.(AU)
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: 731916 LILACS-Express
Autor: Álvarez Serrano, Esteban; Casola Crespo, Eugenio; Rivero Fernández, Fidel; Vilas Martínez, Lisandro.
Título: MENINGOENCEFALITIS EN EL CURSO DE UN HERPES ZÓSTER FACIAL / Meningoencephalitis in the course of an herpes zoster facialis
Fonte: Arch. méd. Camaguey;11(4):0-0, jul.-ago. 2007.
Idioma: es.
Resumo: La infección por el virus varicela zóster como causa de meningoencefalitis es infrecuente, especialmente si el paciente es inmunocompetente. Se presenta un caso de paciente mestizo, de 42 años, profesor de Educación Física, con cuadro de herpes zóster facial, con intenso dolor, lesiones eritematosas con vesículas que afectan la parte izquierda de la nariz, párpado y ojo izquierdo, así como la hemifrente del mismo lado, fiebre de 39- 40oc, desorientación, rigidez de nuca, vómitos intensos en proyectil. Se realiza punción lumbar, la cual resulta francamente patológica. Se impone tratamiento con Aciclovir, Inmunomoduladores, Neuroprotectores y Vitaminoterapia, se obtiene resolución del cuadro neurológico, dermatológico y oftalmológico. Se comenta el cuadro clínico, su diagnóstico y se revisa la literatura.(AU)

The infection by the varicella-zoster virus as cause of meningoencephalitis is infrequent, especially if the patient is immunocompetent. A case of a 42 years-old, mixed race patient is presented, Physical Education professor, with a picture of herpes zoster facialis, intense pain, erythematous lesions with vesicles that affect the left side of the nose, eyelid and left eye, as well as the hemiforhead of the same side, fever about 39- 40oc, disorientation, inflexibility of the nape, intense projectile vomitings. Lumbar puncture is carried out, which turns out to be pathological. Treatment with acyclovir, immunomodulators, neuroprotectors and vitaminotherapy, is imposed, resolution of the dermatological, neurological and ophthalmological picture, was obtained. The clinical chart, and its diagnosis is commented and the literature is revised.(AU)
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: 731900 LILACS-Express
Autor: Paulino Basulto, Rainer.
Título: MENINGITIS BACTERIANA AGUDA / Acute bacterial meningitis
Fonte: Arch. méd. Camaguey;11(3):0-0, Mayo.-jun. 2007.
Idioma: es.
Resumo: Estudios clínicos avanzados proponen múltiples terapéuticas dirigidas a neutralizar citoquinas proinflamatorias que participan en la destrucción de la barrera hematomeníngea y la producción del edema cerebral, las cuales disminuyen la respuesta del huésped de tipo inflamatoria. Sin embargo, se piensa que una intervención rápida y temprana sobre el paciente, recordando que esta enfermedad no tiene signo patonogmónico es la principal arma del clínico moderno para realizar un diagnóstico oportuno y evitar así secuelas en el paciente y la familia. Se revisó información actualizada sobre este polémico tema para recopilar la mayor cantidad de experiencia y mejorar la calidad de la atención a nuestros enfermos.(AU)

Advanced clinical studies propose multiple therapeutic directed to neutralize proinflammatory cytokines that participate in the destruction of the hematomeningeal barrier and in the production of the cerebral edema, which decrease the host response of inflammatory type. Nevertheless, it is consider that an early and fast intervention on the patient, reminding that this illness does not have pathognomonic sign that is the main tool of the modern clinician to carry out an opportune diagnosis and to avoid thus consequences in the patient and in the family. Updating information on this controversial theme was revised to compile the greater quantity of experience and to improve the quality attention to our sickpersons.(AU)
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: 731737 LILACS-Express
Autor: Reguero, Ma. Teresa; Flores, Vanessa; Uribe, Laura Patricia; González, Elsa Beatriz; Mantilla, José Ramón; Valenzuela de Silva, Emilia María; Falquet, Laurent; Barreto-Hernández, Emiliano.
Título: Análisis genómico del resistoma de la cepa de Acinetobacter baumannii ABIBUN 107m multi-resistente y persistente en hospitales colombianos / Genomic analysis of the resistome of the strain of Acinetobacter baumannii ABIBUN 107m multi-resistant and persistent in colombian hospitals
Fonte: Rev. colomb. biotecnol;16(2):104-113, jul.-dic. 2014. tab.
Idioma: es.
Resumo: Acinetobacter baumannii es una bacteria, causante de infecciones asociadas a la atención en salud como neumonía, septicemia, meningitis e infecciones urinarias entre otras. Se caracteriza por su capacidad para desarrollar y acumular rápidamente una gran variedad de mecanismos de resistencia a antibióticos. En esta investigación se realizó el análisis genómico de una cepa de A. baumannii ABIBUN 107m que forma parte de un clon persistente en hospitales colombianos, resistente a los antibióticos carbapenémicos (imipenem y meropenem), antibióticos de elección en el tratamiento infecciones causadas por este microorganismo. El genoma de esta bacteria fue secuenciado utilizando técnicas de alto rendimiento, ensamblado y anotado, obteniéndose un genoma constituido por 3954000 pb con 56 contigs; consta de 4256 genes con un tamaño promedio de 912 pb; 3796 CDS de los cuales por anotación 2884 se asignaron a COG; 57 tRNA y un porcentaje de GC de 38,74%. A. baumannii ABIBUN 107m es resistente a β-lactámicos, aminoglicósidos, quinolonas, tetraciclina, sulfonamida y colistina. En su genoma se localizaron genes asociados con el perfil de resistencia ya que presenta serin β-lactamasas (blaADC-38, blaOXA-64, blaOXA-23, bla ampC-like, bla amp(H)-like), metalo β-lactamasa_B; proteínas de unión a penicilina de elevada masa molecular, secuencias de inserción tipo ISAba1; mutaciones en los genes de DNA girasa y topoisomerasa IV subunidad A (gyrA y parC); enzimas modificadoras de aminoglicósidos (aphA-like, aad -like); cloranfenicol aciltransferasa (cat) y dehidropteroato sintasa (sul-1). Se identificaron genes pertenecientes a cinco familias de sistemas de eflujo (RND, MATE, MSF, ATP, SMR).(AU)

Acinetobacter baumannii is a bacterium causing health care associated infections such as pneumonia, septicemia, meningitis and urinary infections amongst others. It has great capacity to quickly develop and gather a big variety of drug resistance mechanisms. In this research, the genome of strain A. baumannii ABIBUN 107m was analyzed wich forms part of a persistent clon in Colombian hospitals and it’s also resistant to carbapenems (imipenem and meropenem), which are the election antibiotics for treatment of infections caused by this microorganism. The genome was sequenced using high performance technology, assembled and annotated. As a result, we obtained a 3954000 bp genome, with 56 contigs; 4256 genes with average size of 912 bp; 3796 CDS; 2884 were assigned to COG; 57 tRNA and GC percentage of 38,74%. The A. baumannii strain ABIBUN 107m, is resistant to the following antibiotic groups: β-lactams, aminoglycosides, quinolones, tetracycline, sulfonamide and colistin. Genes associated with this resistance profile were found in A. baumannii ABIBUN 107m genome serino β-lactamases (blaADC-38, blaOXA-64, blaOXA-23, bla ampC-like, bla amp(H)-like), metallo β-lactamase_B; High Molecular Mass penicillin binding proteins, ISAba1 type insertion sequences, mutations of DNA gyrase and topoisomerase IV subunit A (gyrA and parC); aminoglycoside modifying enzymes (aphA-like, aadA-like); choramphenicol acyltransferase (cat) and dehydropteroate synthase (sul-1). Genes belonging to five different efflux systems were identified (RND, MATE, MSF, ATP, SMR).(AU)
Responsável: CO332 - Facultad de Medicina


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Id: 731270 LILACS-Express
Autor: Lourenço, Daniela M.R.; Buscatti, Izabel M.; Lourenço, Benito; Monti, Fernanda C.; Paz, José Albino; Silva, Clovis A..
Título: Neurite óptica em paciente com artrite idiopática juvenil / Optic neuritis in juvenile idiopathic arthritis patient
Fonte: Rev. bras. reumatol;54(6):489-489, Nov-Dec/2014.
Idioma: pt.
Projeto: Fundação de Amparo à Pesquisa do Estado de São Paulo; . Fundação de Amparo à Pesquisa do Estado de São Paulo; . Conselho Nacional do Desenvolvimento Científico e Tecnológico. 2008/58238-4; 2011/12471-2; 302724/2011-7.
Resumo: O bloqueio do TNF tem tido sucesso no tratamento de algumas doenças reumáticas, como a espondiloartrite. Relatam-se muitas complicações infecciosas com a terapia anti-TNF, principalmente infecções bacterianas, micobacterianas, virais e fúngicas. A Entamoeba histolytica é um protozoário extracelular que causa principalmente colite e abscesso hepático, sendo que a perfuração intestinal é uma complicação rara, com alta mortalidade. O TNF é considerado o principal mediador da imunidade celular contra a amebíase. Inicialmente, é quimiotático para a E. histolytica, potencializando sua adesão ao enterócito por meio da lectina galactose-inibível, e depois ativando os macrófagos para matarem a ameba pela liberação de NO; assim, o bloqueio do TNF poderia ser prejudicial, aumentando a virulência amebiana. Descreve-se o caso de uma mulher de 46 anos com espondiloartrite que apresentou uma perfuração do colo por colite amebiana invasiva durante uso de anti-TNF.(AU)

Optic neuritis (ON) was rarely reported in juvenile idiopathic arthritis (JIA) patients, particularly in those under anti-tumor necrosis factor alpha blockage. However, to our knowledge, the prevalence of ON in JIA population has not been studied. Therefore, 5793 patients were followed up at our University Hospital and 630 (11%) had JIA. One patient (0.15%) had ON and was reported herein. A 6-year-old male was diagnosed with extended oligoarticular JIA, and received naproxen and methotrexate subsequently replaced by leflunomide. At 11 years old, he was diagnosed with aseptic meningitis, followed by a partial motor seizure with secondary generalization. Brain magnetic resonance imaging (MRI) and electroencephalogram showed diffuse disorganization of the brain electric activity and leflunomide was suspended. Seven days later, the patient presented acute ocular pain, loss of acuity for color, blurred vision, photophobia, redness and short progressive visual loss in the right eye. A fundoscopic exam detected unilateral papilledema without retinal exudates. Orbital MRI suggested right ON. The anti-aquaporin 4 (anti-AQP4) antibody was negative. Pulse therapy with methylprednisolone was administered for five days, and subsequently with prednisone, he had clinical and laboratory improvement. In conclusion, a low prevalence of ON was observed in our JIA population. The absence of anti-AQP4 antibody and the normal brain MRI do not exclude the possibility of demyelinating disease associated with chronic arthritis. Therefore, rigorous follow up is required.(AU)
Responsável: BR1.1 - BIREME


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Id: 730933 LILACS-Express
Autor: Osorio, Natalia; López, Yúrika; Jaramillo, Juan Camilo.
Título: Histoplasmosis del sistema nervioso central en un paciente inmunocompetente / Histoplasmosis of the central nervous system in an immunocompetent patient
Fonte: Biomédica (Bogotá);34(4):506-513, oct.-dic. 2014. tab.
Idioma: es.
Resumo: La histoplasmosis es una afección polifacética producida por el hongo dimorfo Histoplasma capsulatum , cuyas esporas son inhaladas y llegan al pulmón, órgano primario de infección. La forma meníngea, considerada como una de las manifestaciones más graves de esta micosis, suele presentarse en individuos con alteraciones en la inmunidad celular: pacientes con síndrome de inmunodeficiencia humana adquirida, con lupus eritematoso sistémico o con trasplante de órgano sólido, así como en lactantes, debido a su inmadurez inmunológica. La forma de presentación más usual es de resolución espontánea y se observa en individuos inmunocompetentes que se han expuesto a altas concentraciones de conidias y fragmentos miceliares del hongo. En estas personas, la afección se manifiesta por trastornos pulmonares y por la posterior diseminación a otros órganos y sistemas. Se presenta un caso de histoplasmosis del sistema nervioso central en un niño inmunocompetente.(AU)

Histoplasmosis is a multifaceted condition caused by the dimorphic fungi Histoplasma capsulatum whose infective spores are inhaled and reach the lungs, the primary organ of infection. The meningeal form, considered one of the most serious manifestations of this mycosis, is usually seen in individuals with impaired cellular immunity such as patients with acquired immunodeficiency syndrome, systemic lupus erythematous or solid organ transplantation, and infants given their immunological immaturity. The most common presentation is self-limited and occurs in immunocompetent individuals who have been exposed to high concentrations of conidia and mycelia fragments of the fungi. In those people, the condition is manifested by pulmonary disorders and late dissemination to other organs and systems. We report a case of central nervous system histoplasmosis in an immunocompetent child.(AU)
Responsável: CO332 - Facultad de Medicina


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Id: 730777
Autor: Gualberto, Felipe Augusto Souza.
Título: Valor diagnóstico da nested PCR em tempo real em pacientes com meningite tuberculosa / Diagnostic value of the nested real time PCR patients with tuberculous meningitis.
Fonte: São Paulo; s.n; 2014. [157] p. ilus, graf, tab.
Idioma: pt.
Tese: Apresentada a Universidade de São Paulo. Faculdade de Medicina para obtenção do grau de Doutor.
Resumo: Introdução: A meningite tuberculosa (MTB) é a forma mais grave e fatal de tuberculose. O diagnóstico oportuno e o tratamento adequado e precoce são os principais fatores associados com o bom prognóstico. Os métodos utilizados na prática médica diária - achados clínicos, exames de imagem e análise de líquido cefalorraquidiano (LCR) - têm baixa acurácia. A pesquisa do DNA do Mycobacterium tuberculosis no LCR através da reação em cadeia da polimerase (PCR, do inglês polimerase chain reaction) com a metodologia nested é promissora, especialmente quando associada à praticidade da amplificação do DNA em tempo real. Objetivo: Avaliar o valor diagnóstico da nested PCR em tempo real (nRT-PCR, do inglês nested real-time PCR) na investigação de pacientes com MTB. Métodos: Estudo observacional realizado em duas fases: uma prospectiva e outra retrospectiva. Na fase prospectiva, foram incluídos pacientes com suspeita de MTB internados no Instituto de Infectologia Emílio Ribas (IIER). Informações clínicas, laboratoriais e radiológicas foram coletadas, assim como amostra de LCR de todos os pacientes. A partir de critérios internacionais padronizados, os pacientes foram categorizados como "MTB Definitiva", "MTB Provável", "MTB Possível" e "Não MTB". A nRT-PCR, utilizando o gene alvo mpt64, foi realizada em todas as amostras de LCR no Laboratório de Meningites Bacterianas do Instituto Adolfo Lutz. Sensibilidade, especificidade e intervalos de confiança (IC 95%) da nRT-PCR foram calculados com base no padrão-ouro (cultura positiva para M. tuberculosis ou isolamento de BAAR no sistema nervoso central) e nos pacientes com outros diagnósticos estabelecidos (Não MTB). Também foi calculada a proporção de pacientes com a nRT-PCR positiva em cada categoria clínica. Na fase retrospectiva, foi realizada uma revisão de prontuários de pacientes que tiveram a nRT-PCR solicitada no IIER e no Centro de Referência e Treinamento em DST/AIDS. Os mesmos procedimentos...(AU)

Background: Tuberculous meningitis (TBM) is the most serious and lethal presentation of tuberculosis. Timely diagnosis and appropriated treatment are the main factors associated with good outcome. Methods used in the daily medical practice - clinical, radiological and cerebrospinal fluid (CSF) findings - have low accuracy. Search for Mycobacterium tuberculosis DNA in the CSF by polymerase chain reaction (PCR) using the nested methodology is promising, especially when combined with the practical approach of the real time DNA amplification. Objective: To evaluate the diagnostic value of a nested real-time PCR (nRT-PCR) in the investigation of patients with TBM. Methods: A two-phase observational study was carried out: prospective and retrospective. In the prospective phase, patients with suspected TBM hospitalized at "Instituto de Infectologia Emílio Ribas" (IIER) were included. Clinical, laboratory and radiological data were collected, as well as CSF samples of all patients. According to international standard criteria, patients were categorized as "TBM Definite", "TBM Probable", "TBM Possible" and "Not TBM". The nRT-PCR, using the mpt64 gene, was performed on all CSF sample in the Laboratory of Bacterial Meningitis, Adolfo Lutz Institute. Sensitivity, specificity and confidence intervals (95% CI) of the nRT-PCR were calculated based on the gold standard (culture positive for M. tuberculosis or AFB isolation on the central nervous system) and on patients with other established diagnoses ("Not TBM"). The proportion of patients with a positive nRT-PCR in each clinical category was also calculated. In the retrospective phase, medical chart review was performed in those patients who had the nRT-PCR requested in IIER and in the "Centro de Referência e Treinamento em DST/AIDS". The same diagnostic categorization and calculations of sensitivity and specificity were adopted. Results: 102 patients were included in the prospective phase, 92 of them...(AU)
Descritores: Tuberculose Meníngea/diagnóstico
Mycobacterium tuberculosis
DNA
Reação em Cadeia da Polimerase em Tempo Real/métodos
Técnicas de Amplificação de Ácido Nucleico
Líquido Cefalorraquidiano
Sensibilidade e Especificidade
Grupos Diagnósticos Relacionados/classificação
Limites: Humanos
Masculino
Adulto
Responsável: BR66.1 - Divisão de Biblioteca e Documentação
BR66.1


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Id: 730760
Autor: Corrêa, Sebastião Francisco Miranda.
Título: Radiocirurgia e radioterapia estereotática no tratamento de meningeomas sintomáticos do seio cavernoso / Radiosurgery and stereotactic radiotherapy in the treatment of symptomatic cavernous sinus meningiomas.
Fonte: São Paulo; s.n; 2014. [122] p. ilus, tab, graf.
Idioma: pt.
Tese: Apresentada a Universidade de São Paulo. Faculdade de Medicina para obtenção do grau de Doutor.
Resumo: Introdução: Radiocirurgia estereotática (RCE) e radioterapia estereotática fracionada (RCEF) são inovações modernas de procedimentos radioterápicos, de alta precisão que modelam o feixe de radiação para coincidir com o contorno da lesão, por meio de um sistema de imobilização exata do paciente ao aparelho, com definição do alvo através da fusão de imagens de RM, TC, Angiografia e PET/CT; em que pelas coordenadas de referência estereotática, determina-se que a dose de radiação de alta energia prescrita pelo médico seja depositada somente no volume-alvo, com preservação dos tecidos sadios, órgãos ou estruturas localizadas em suas adjacências. Meningeomas do seio cavernoso (MSCs) representam um problema especial porque podem evoluir comprimindo ou infiltrando estruturas neurovasculares presentes no seio cavernoso. Há evidências de que a RCE e a RCEF proporcionam controle satisfatório do crescimento dos meningeomas do seio cavernoso (MSCs) com efeitos adversos reduzidos. Objetivo: Avaliar resultados da avaliação clínica e da neuroimagem de doentes sintomáticos com MSCs tratados com RCEF ou RCE exclusivamente ou de modo adjuvante à neurocirurgia. Casuística e métodos: Estudo tipo coorte e retrospectivo sobre a avaliação de 89 doentes com MSC sintomático tratados com RCE (36%) ou RCEF (64%) entre janeiro de 1994 e março de 2009 e acompanhados até o final de 2012. Haviam sido submetidos à ressecação neurocirúrgica parcial (Simpson IV) ou à biopsia (Simpson V) previamente à radioterapia 29,2% dos doentes. A dose média de RCE foi de 14Gy, e a dose total de RCEF variou entre 50,4 e 54Gy, sendo fracionada em 1,8-2Gy/dose/dia. Resultados: O período de acompanhamento variou entre 36 e 180 meses (mediana de 73 meses). A percentagem de melhora dos sintomas neuroclínicos individuais e de melhora clínica e radiológica (p > 0,05) apresentou valores semelhantes nos doentes tratados com RCE ou RCEF, sendo respectivamente de 41,6% e 48,3%. Em 37% dos doentes, houve...(AU)

Introduction: Stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (FSRS) are modern innovations in radiotherapy procedures, precision shaping the radiation beam to match the contour of the lesion, through a system of accurate patient immobilization to the device, defining target through the fusion of MRI, CT, angiography and PET / CT, which is determined by reference to stereotactic coordinates. The radiation dose of high energy prescribed by the doctor to be delivery only in the target interest, with preservation of healthy tissues, organs or structures located in their vicinity. Cavernous sinus meningiomas (CSMs) pose a special problem because they can evolve compressing or infiltrating the neurovascular structures present of the cavernous sinus. There are evidences that SRS and FRS are efficient in the treatment of CSMs. Objectives: The evaluation of the long-term clinical results and neuroimaging findings in patients with symptomatic CSM treated with FSRT or SRS as single therapy or after a previous neurosurgical treatment. Patients and methods: Retrospective cohort study involving 89 patients with symptomatic CSMs treated with SRS (36%) or FSRS (64%) from January 1994 to March 2009, and followed until the end of 2012. Previous neurosurgical partial resection (Simpson IV) or biopsies (Simpson V) had been performed in 29.2% of the patients. The median dose of SRS was 14Gy and the total dose of FSRT ranged from 50.4 to 54Gy, fractionated in 1.8 to 2Gy/dose/day. Results: The follow-up period ranged from 36 to 180 months (median= 73months). There was improvement in the individual symptoms and in the clinical and radiological findings regardless the radiotherapeutic method in 41.6% and 48.3% of the patients treated with SRS or FSRT, respectively (p > 0,05). In 37% of the patients, at least one neurological complaint present before the treatment did not change and in 43.8% patients, the image of the tumor remained stable....(AU)
Descritores: Neoplasias Meníngeas/radioterapia
Meningioma
Seio Cavernoso
Radiocirurgia/efeitos adversos
Radiocirurgia/normas
Fracionamento de Dose
Neuroimagem
Neurocirurgia
Limites: Humanos
Masculino
Feminino
Adulto
Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: BR66.1 - Divisão de Biblioteca e Documentação
BR66.1


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Quevedo, Joäo
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Id: 730589 LILACS-Express
Autor: Barichello, Tatiana; Fagundes, Glauco D.; Generoso, Jaqueline S.; Dagostin, Caroline S.; Simões, Lutiana R.; Vilela, Márcia C.; Comim, Clarissa M.; Petronilho, Fabricia; Quevedo, João; Teixeira, Antonio L..
Título: Environmental enrichment restores cognitive deficits induced by experimental childhood meningitis
Fonte: Rev. bras. psiquiatr;36(4):329-329, Oct-Dec/2014. graf.
Idioma: en.
Resumo: Objective: To evaluate the influence of environmental enrichment (EE) on memory, cytokines, and brain-derived neurotrophic factor (BDNF) in the brain of adult rats subjected to experimental pneumococcal meningitis during infancy. Methods: On postnatal day 11, the animals received either artificial cerebrospinal fluid (CSF) or Streptococcus pneumoniae suspension intracisternally at 1 × 106 CFU/mL and remained with their mothers until age 21 days. Animals were divided into the following groups: control, control + EE, meningitis, and meningitis + EE. EE began at 21 days and continued until 60 days of age (adulthood). EE consisted of a large cage with three floors, ramps, running wheels, and objects of different shapes and textures. At 60 days, animals were randomized and subjected to habituation to the open-field task and the step-down inhibitory avoidance task. After the tasks, the hippocampus and CSF were isolated for analysis. Results: The meningitis group showed no difference in performance between training and test sessions of the open-field task, suggesting habituation memory impairment; in the meningitis + EE group, performance was significantly different, showing preservation of habituation memory. In the step-down inhibitory avoidance task, there were no differences in behavior between training and test sessions in the meningitis group, showing aversive memory impairment; conversely, differences were observed in the meningitis + EE group, demonstrating aversive memory preservation. In the two meningitis groups, IL-4, IL-10, and BDNF levels were increased in the hippocampus, and BDNF levels in the CSF. Conclusions: The data presented suggest that EE, a non-invasive therapy, enables recovery from memory deficits caused by neonatal meningitis. .(AU)
Responsável: BR1.1 - BIREME



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