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Id: 720246 LILACS-Express
Autor: Borro, Paolo; Sumberaz, Alessandro; Testino, Gianni.
Título: Pyogenic liver abscess caused by Gemella morbillorum / Absceso hepático piógeno causado por Gemella morbillorum
Fonte: Colomb. med;45(2):77-80, Apr.-June 2014. ilus, tab.
Idioma: en.
Resumo: Even though Gemella morbillorum infection (GMI) is rare in humans, it may, nevertheless, cause endocarditis, meningitis, brain abscess, pleural empyema, nephritis, mediastinitis, and - occasionally - liver abscess. We are describing the case of a 64-year-old Caucasian male admitted with fever and abdominal pain. Laboratory parameters revealed inflammation signs, and instrumental examinations showed the presence of diverticula in the ascending colon. Abdominal ultrasound (US) and computer tomography (CT) showed two focal lesions in the right liver lobe. One had the characteristics of a simple cyst; the second was hypoechoic with a low density area, possibly containing necrotic material. US-guided needle biopsy was found negative for neoplastic cells, showing purulent infiltrate. Pus culture was found positive for GMI. Systemic antibiotic therapy, coupled with repeated US-guided needle aspiration, induced the resolution of the hepatic abscess. Few cases have been reported of hepatic abscess caused by GMI in immunocompetent non-cirrhotic subjects.(AU)

A pesar de que la infección por Gemella morbillorum (GMI, por el término en inglés) es poco común en seres humanos, puede causar endocarditis, meningitis, absceso cerebral, empiema pleural, nefritis, mediastinitis y en ocasiones, absceso hepático. Describimos el caso de un hombre caucásico de 64 años que ingresó con fiebre y dolor abdominal. Los parámetros de laboratorio revelaron signos de inflamación y los exámenes mostraron la presencia de divertículos en el colon ascendente. La ecografía abdominal (US) y la tomografía computarizada (CT) mostró dos lesiones focales en el lóbulo hepático derecho. Una presentó las características de un quiste simple; la segunda fue hipoecóica con una zona de baja densidad, que posiblemente contenía material necrótico. Biopsia con aguja guiada por US dio un resultado negativo para células neoplásicas, mostrando infiltrado purulento. Cultivo de pus fue encontrado positivo para GMI. Una terapia con antibióticos sistémicos, junto con aspiración repetida con aguja guiada por US indujo a la resolución del absceso hepático. Pocos casos se han reportado de absceso hepático causado por GMI en sujetos inmunocompetentes no cirróticos.(AU)
Responsável: CO332 - Facultad de Medicina


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Id: 719981 LILACS-Express
Autor: Correa, José Fernando Guedes; Sucussel Junior, Ari Boulanger; Amorim, Rogério Martins Pires; Loiola, Lucas Santos; Reis, Maristella; Raquel, Megali.
Título: Giant pericallosal artery aneurysm ? Literature review and report of a rare case / Aneurisma gigante de artéria pericalosa ? Revisão da literatura e relato de um caso raro
Fonte: Arq. bras. neurocir;32(3), set. 2013. ilus.
Idioma: pt.
Resumo: Giant pericallosal artery aneurysms are extremely rare. Aneurismatic lesions involving this artery are usually small, tend to early bleeding and might be associated with other lesions. Differential diagnosis of giant aneurysms are not easy and includes tumoral, infectious and vascular mass effect lesions. We report a case of a giant and partially thrombosed left pericallosal artery aneurysm. A 58-year-old man, presented with progressive headaches, seizures and speech alterations initially misdiagnosed as a falx cerebri meningioma. As clinical status continue to worsen, magnetic resonance imaging and digital cerebral angiography were performed and a vascular etiology was considered. The patient was then referred to our hospital for surgical treatment. The peculiarity of this case concerns the difficulty of surgical treatment once the surgeon was not able to obtain control of the afferent artery and the aneurysm neck could not be visualized. Also, the aneurysm adhered to the medial surfaces of the frontal lobes and covered the anterior cerebral arteries. Treatment by means of microsurgical thrombectomy, clipping and resection of the lesion was successfully performed. Microsurgical treatment may provide good results when carefully planned with the help of imaging studies of the lesion. It is essential to keep in mind that flexible approach is of great importance when dealing with giant aneurysmatic lesions of pericallosal artery due to its variety of intraoperative presentation.(AU)

Aneurismas gigantes da artéria pericalosa são raros. Lesões aneurismáticas acometendo essa artéria são, geralmente, pequenas, tendem a sangrar precocemente e associam-se a outras lesões.O diagnóstico diferencial dos aneurismas gigantes é complexo, uma vez que inclui diversas lesões que cursam com efeito de massa, entre elas, as tumorais, infecciosas e vasculares. Relatamos o caso de um aneurisma gigante, parcialmente trombosado, acometendo a artéria pericalosa esquerda. Tratase de um paciente de 58 anos de idade, sexo masculino, apresentando quadro de cefaleia, crises convulsivas e alterações na fala. O achado de uma massa inter-hemisférica de característica hiperdensaà tomografia computadorizada de crânio levou ao diagnóstico errôneo de meningioma da foice cerebral. Uma vez que o quadro clínico do paciente continuou a piorar, optou-se por submetê-lo à ressonância nuclear magnética e à angiografia cerebral digital. A hipótese de etiologia vascular foi então aventada. O paciente foi encaminhado ao nosso serviço para ser submetido a tratamento cirúrgico. A peculiaridade desse caso deve-se à dificuldade de acesso à artéria aferente e de visualização do colo para controle da lesão. Além disso, o aneurisma encontrava-se aderido às faces mediais dos lobos frontais e cobria as artérias cerebrais anteriores. O tratamento cirúrgico por meio de trombectomia microcirúrgica,clipagem e ressecção da lesão pôde ser realizado com sucesso. O tratamento microcirúrgico, quando cuidadosamente planejado por meio de exames de imagem, pode viabilizar a obtenção de resultadossatisfatórios. No entanto, deve-se atentar para o fato de que lesões aneurismáticas gigantes de artéria pericalosa podem se apresentar de diversas formas durante o ato operatório, sendo, portanto, essencialuma abordagem flexível, adaptada às peculiaridades de cada lesão.(AU)
Responsável: BR1.1 - BIREME


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Id: 719306 LILACS-Express
Autor: Tauil, Márcia de Cantuária; Carvalho, Cleidiane Santos Rodrigues de; Vieira, Ataiza César; Waldman, Eliseu Alves.
Título: Meningococcal disease before and after the introduction of meningococcal serogroup C conjugate vaccine. Federal District, Brazil
Fonte: Braz. j. infect. dis;18(4):386-386, Jul-Aug/2014. tab, graf.
Idioma: en.
Projeto: Instituto Adolfo Lutz and the National Council for Scientific and Technological Development. 132840/2011-1.
Resumo: OBJECTIVES: To analyze the behavior of meningococcal disease in the Federal District, Brazil, from 2005 to 2011, and to assess the direct impact of the meningococcal serogroup C conjugate vaccine. METHODS: A descriptive study of cases of meningococcal disease among residents of the Federal District. We included in the study confirmed cases of meningococcal disease reported to the local surveillance. To reduce underreporting we compared data to the Brazilian Mortality Database and the Public Health Laboratory Database. We studied sociodemographic, clinical, and pathogen-related variables. For the assessment of the impact of meningococcal serogroup C conjugate vaccine, which was introduced in 2010 for children under two years of age, we compared the incidence of meningococcal disease before and after vaccine introduction in the recommended age groups for vaccination. RESULTS: We identified 309 cases of meningococcal disease, of which 52.1% were males. The average case fatality rate was 20.7%, the median age was three years and there was a predominance of serogroup C (70.2%) and C:23:P1.14-6 phenotype throughout the study period. In 2005-2009, 2010 and 2011, the incidence rates of meningococcal disease were 2.0, 1.8 and 0.8/100,000 inhabitants/year, while mortality rates were 0.4, 0.4 and 0.2/100,000 inhabitants/year, respectively. In the first and last periods, the incidence in poorer and more affluent areas were, respectively, 2.0 and 0.8, and 0.9 and 0.0/100,000 inhabitants/year. Comparing 2009 (the year prior to the introduction of meningococcal serogroup C conjugate vaccine) and 2011, there was 85% reduction in the incidence of serogroup C meningococcal disease in children under four years of age, from 9.0 to 1.3/100,000 (p < 0.01). CONCLUSIONS: The meningococcal serogroup C conjugate vaccine strategy implemented in Brazil proved highly effective and had a strong direct impact on the target population. However, case ...(AU)
Responsável: BR1.1 - BIREME


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Id: 718124 LILACS-Express
Autor: Puri, Basant K.; Monro, Jean A.; Julu, Peter O. O.; Kingston, Michele C.; Shah, Mussadiq.
Título: Hyperosmia in Lyme disease / Hyperosmia na doença de Lyme
Fonte: Arq. neuropsiquiatr;72(8):597-597, 08/2014. tab.
Idioma: en.
Resumo: Neurological involvement in Lyme disease has been reported to include meningitis, cranial neuropathy and radiculoneuritis. While it is known that in some cases of asceptic meningitis patients may develop hyperosmia, the association between hyperosmia and Lyme disease has not previously been studied. Objective To carry out the first systematic study to ascertain whether hyperosmia is also a feature of Lyme disease. Method A questionnaire regarding abnormal sensory sensitivity in respect of the sense of smell was administered to 16 serologically positive Lyme disease patients and to 18 control subjects. Results The two groups were matched in respect of age, sex and body mass. None of the 34 subjects was suffering from migraine. Eight (50%) of the Lyme patients and none (0%) of the controls suffered from hyperosmia (p=0.0007). Conclusion This first systematic controlled study showed that Lyme disease is associated with hyperosmia. .(AU)

Tem sido descrito acometimento neurológico na doença de Lyme: meningite, neuropatia de nervos cranianos, e radiculoneurite. É bem conhecida a ocorrência de hiperosmia em alguns casos de meningites assépticas, mas a associação de hiperosmia com doença de Lyme ainda não foi relatada. Objetivo Conduzir um estudo sistemático para investigar se a hiperosmia é característica também da doença de Lyme. Método Foi aplicado um questionário pesquisando a ocorrência de sensibilidade anormal em relação ao sentido da olfação a 16 pacientes com sorologia positiva para doença de Lyme e a 18 controles normais. Os dois grupos foram pareados em relação a idade, sexo e massa corporal. Nenhum dos 34 sujeitos sofria de enxaqueca. Resultados Foi detectada hiperosmia em 8 sujeitos com doença de Lyme (50%) enquanto que a hiperosmia não apareceu em nenhum sujeito do grupo controle (p=0,0007). Conclusão Doença de Lyme está associada à hiperosmia. .(AU)
Responsável: BR1.1 - BIREME


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Id: 717343 LILACS-Express
Autor: Ramírez Quiñones, Jorge Alonso; Novoa Mosquera, María Elena.
Título: Absceso cerebral complicado con ruptura intraventricular: reporte de dos casos y revisión de la literatura / Intraventricular rupture of brain abscess: report of two cases and review of the literature
Fonte: An. Fac. Med. (Perú);75(2):159-163, abr. 2014. ilus.
Idioma: es.
Resumo: El absceso cerebral es una patología infecciosa infrecuente cuyo diagnóstico oportuno y tratamiento adecuado conducen a un buen pronóstico en la mayoría de los casos. La ruptura intraventricular es una complicación rara del absceso cerebral con elevada mortalidad; se caracteriza por compromiso brusco de la conciencia, con aparición de signos de irritación meníngea y hallazgos radiológicos compatibles con un drenaje de secreción purulenta hacia los ventrículos. El tratamiento incluye la administración de antibióticos intravenosos e intratecales asociados a una rápida intervención quirúrgica para drenaje del absceso y del contenido intraventricular. Presentamos dos casos de absceso cerebral complicado con ruptura intraventricular, que mostraron características clínicas y radiológicas propias de esta condición, con evolución favorable solo con tratamiento antibiótico endovenoso durante seis a diez semanas, respectivamente.(AU)

Brain abscess is an infrequent infectious disease that has a good prognosis in most of the cases with timely diagnosis and suitable treatment. Intraventricular rupture is a rare complication of the brain abscess with high mortality. It is characterized by a sudden consciousness compromise with signs of meningeal irritation and radiological findings compatible with purulent drainage into the ventricles. Treatment includes administration of intravenous and intrathecal antibiotics associated to prompt surgical intervention to drain the abscess and intraventricular content. Two cases of brain abscess complicated with intraventricular rupture showing clinical and radiological features typical of this condition and favorable outcome with intravenous antibiotic treatment during six and ten weeks respectively are reported.(AU)
Responsável: PE1.1 - DUGIC - Dirección Universitária de Gestión de la Información Científica


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Id: 717205 LILACS-Express
Autor: Solórzano Álava, Luis Fernando; Martini Robles, Luiggi; Hernández Álvarez, Hilda; Sarracent Pérez, Jorge; Muzzio Aroca, Jenny; Rojas Rivero, Lázara.
Título: Angiostrongylus cantonensis: un parásito emergente en Ecuador / Angiostrongylus cantonensis / an emerging parasite in Ecuador
Fonte: Rev. cuba. med. trop;66(1):20-33, ene.-mar. 2014.
Idioma: es.
Resumo: Introducción: en 2008 se notificó por primera vez la presencia de Angiostrongylus cantonensis en Ecuador, así como los primeros casos de una enfermedad emergente causada por sus larvas, la meningitis eosinofilica. Métodos: se realizó una revisión de la literatura básica y actualizada sobre aspectos generales de Angiostrongylus cantonensis en el mundo y particulares en Ecuador, que incluyó los hallazgos parasitológicos, clínicos y malacológicos relacionados con la enfermedad. Resultados: se informan los hallazgos iniciales acerca de la aparición del parásito en Ecuador, así como la amplia distribución geográfica de sus hospederos intermediarios en el territorio nacional. Además, se notifican los brotes de meningitis eosinofilica por Angiostrongylus cantonensis y un caso de angiostrongyliosis ocular, informados oficialmente por el Ministerio de Salud Pública. Conclusiones: Angiostrongylus cantonensis es un parásito emergente en Ecuador, cuyo diagnóstico en la actualidad es clínico y epidemiológico, de ahí la importancia de contar con métodos de laboratorio que lo oriente. Por otra parte, es importante que se promuevan campañas de promoción y prevención de salud que contribuyan a romper la cadena de transmisión de la enfermedad.(AU)

Introduction: the presence of Angiostrongylus cantonensis and the first cases of eosinophilic meningitis, an emerging disease caused by its larvae, were first reported in Ecuador in the year 2008. Methods: a review was conducted of the basic and current bibliography on general aspects of Angiostrongylus cantonensis both worldwide and in Ecuador, including parasitological, clinical and malacological findings. Results: initial findings are reported about the emergence of the parasite in Ecuador, as well as the broad geographic distribution of its intermediate hosts in the national territory. Information is also provided about outbreaks of eosinophilic meningitis due to Angiostrongylus cantonensis and a case of ocular angiostrongylosis, based on official reports by the Ministry of Public Health. Conclusions: Angiostrongylus cantonensis is an emerging parasite in Ecuador whose diagnosis is currently based on clinical and epidemiological findings. Hence the importance of developing relevant laboratory methods. On the other hand, it is important to foster health promotion and prevention campaigns aimed at stopping the transmission of the disease.(AU)
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: 717166 LILACS-Express
Autor: Rodríguez Fernández, Olga María; Sanchén Casas, Alexis; Prince Martínez, Ivette Alicia; Resik Aguirre, Sonia.
Título: Meningoencefalitis por echovirus30 complicada: reporte de dos casos / Complicated meningoencephalitis caused by echovirus30: report of two cases
Fonte: Arch. méd. Camaguey;18(3):317-326, abr.-jun. 2014.
Idioma: es.
Resumo: Introducción: entre los principales virus causales de meningoencefalitis de evolución benigna en el 95 % de los niños están los enterovirus. Ante la infrecuencia de la gravedad de estos procesos, presentamos dos infantes complicados a Echovirus 30 recluidos en la unidad de terapia intensiva del Hospital Pediátrico Provincial Docente Eduardo Agramonte Piña de Camagüey, con el objetivo de mostrar la capacidad de estos agentes de producir daños severos del sistema nervioso central. Casos clínicos: se presentaron niños de 11 meses y un año de edad respectivamente ambos remitidos del municipio de Florida en la provincia de Camagüey que presentaron fiebre, vómitos, somnolencia, astenia y anorexia; por lo que se les realizó punciones lumbares con resultados de aumento de las células a predominio linfocitario, además uno de ellos presentó graves trastornos de perfusión, edema cerebral severo, y leucograma con granulaciones tóxicas; el otro paciente a las 72 horas de su ingreso comenzó con irritabilidad, ataxia y movimientos incordinados de los brazos; por lo que se le diagnosticó una cerebelitis con pronóstico reservado. El estudio virológico de las heces de ambos enfermos realizado en el Instituto de Medicina Tropical en La Habana, arrojó ECHO virus 30. Los dos enfermos tuvieron estadía hospitalaria de 15 y 20 días respectivamente con diagnóstico de meningoencefalitis viral. Conclusiones: los casos expuestos nos muestran el potencial de los enterovirus como el ECHO 30 de producir meningoencefalitis de evolución seria e impredecible, aunque nuestros pacientes resolvieron sin secuelas, es importante la vigilancia mantenida hacia los enterovirus en la población infantil para prevenir las infecciones del sistema nervioso central.(AU)

Introduction: enteroviruses are among the main causal viruses of meningoencephalitis of mild evolution in the 95 % of children. Given the infrequency of the seriousness of these complaints, the cases of two infants complicated with echovirus 30 are presented. The patients were confined to the intensive care unit of the Eduardo Agramonte Piña Teaching Provincial Pediatric Hospital. The cases are presented with the objective of showing the capacity of these agents of producing severe damage in the central nervous system. Clinical cases: the cases of two infants of 11 months and one year old are presented; both infants were brought about a remission of the Florida municipality, province of Camagüey. Both patients presented vomits, sleepiness, asthenia, and anorexia; because of that, they underwent a lumbar puncture the results of which were as follow: increase of the cells with lymphocytic predominance. One of the patients also presented serious disorders of perfusion, severe brain edema and the leucograma produced the presence of toxic granulations; the other patient started presenting irritability, ataxia, and uncoordinated movements of the arms 72 hours after being admitted and was diagnosed with cerebellitis with a reserved prognosis. The virology study of the feces of both patients was made in the Tropical Medicine Institute in Havana; the study produced the following result: echovirus 30. The patients had a hospital stay of 15 and 20 days respectively and were diagnosed with viral meningoencephalitis. Conclusions: the cases presented show us the potential of enteroviruses like ECHO 30 of producing meningoencephalitis of serious and unpredictable evolution. Although the patients recovered without aftereffects, a maintained vigilance on enteroviruses in children is important to prevent infections in the central nervous system.(AU)
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: 717131 LILACS-Express
Autor: Sanchén Casas, Alexis; Rodríguez Fernández, Olga María; Cordero Rodriguez, Magaly; Sarmiento Pérez, Luis Raymond.
Título: Frecuencia de enterovirus en niños con meningoencefalitis viral / Enterovirus frequency in children with viral meningoencephalitis
Fonte: Medisan;18(7):908-914, jun.-jul. 2014.
Idioma: es.
Resumo: Introducción: el enterovirus es uno de los agentes causales que suelen afectar el sistema nervioso central. Objetivos: determinar la frecuencia de enterovirus en niños hospitalizados con meningoencefalitis. Métodos: se efectuó un estudio descriptivo-observacional de 66 infantes con meningoencefalitis viral, ingresados en el Hospital Pediátrico Provincial "Dr. Eduardo Agramonte Piña" de la provincia de Camagüey, desde enero de 2011 hasta julio de 2012. Resultados: 26,6 % de los afectados fueron aislados por enterovirus en el año 2011 y 84,3 % en el 2012. El agente diagnosticado fue ECHO virus 30, el cual afectó todas las edades con positividad entre 63,0 y 100,0 %. Prevaleció el sexo masculino (78,4 %) procedentes de 11 municipios, con positividades superiores a 70 % en Florida y Camagüey. Los síntomas predominantes fueron cefaleas, fiebre, vómitos y malestar general. A la mayoría de los pacientes se le realizó estudio citoquímico del líquido cefaloraquídeo entre 10 y 199 células por 10(6)/L con predominio linfocitario. Conclusiones: gran parte de los afectados evolucionaron satisfactoriamente con hospitalización de solo 4 días.(AU)

Introduction: the enterovirus is one of the causal agents usually affecting the central nervous system. Objectives: to determine the enterovirus frequency in children hospitalized with meningoencephalitis. Methods: a descriptive-observational study of 66 infants with viral meningoencephalitis admitted in "Dr. Eduardo Agramonte Piña" Provincial Pediatric Hospital was carried out in Camagüey province from January, 2011 to July, 2012. Results: 26.6% of the affected ones were isolated due to enterovirus in the year 2011 and 84.3% in 2012. The diagnosed agent was ECHO virus 30, which affected all the ages with positivity between 63.0 and 100.0%. The male sex prevailed (78.4%) coming from 11 municipalities, with positivities higher than 70% in Florida and Camagüey. The predominant symptoms were migraines, fever, vomits and general uneasiness. Most of the patients had a cytochemical study of the cerebrospinal fluid from 10 and 199 cells per 106/L with lymphocytes prevalence. Conclusions: great number of the affected patients had a satisfactory clinical course with hospital stay of just 4 days.(AU)
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: 717034 LILACS-Express
Autor: Zuñiga Zambrano, Yenny Carolina; Vásquez, Rafael.
Título: Trastornos psiquiátricos en pacientes pediátricos con lupus eritematoso sistémico en un hospital de referencia / Psychiatric Disorders in Pediatric Patients With Systemic Lupus Erythematosus in a Reference Hospital
Fonte: Rev. colomb. psiquiatr;43(2):73-79, abr. 2014. ilus, tab.
Idioma: es.
Resumo: Objetivo: Describir las manifestaciones psiquiátricas de pacientes con lupus eritematoso sistémico atendidos en la Fundación Hospital de la Misericordia. Métodos: Estudio observacional descriptivo. Se revisaron historias clínicas y paraclínicos de pacientes hospitalarios y ambulatorios (2007-2013). Se seleccionó a 39 pacientes. Se utilizó SPSS19 para el análisis estadístico. Se consideró estadísticamente significativo un valor de p < 0,05. Resultados: La media de edad era 13,7 ± 2,33 (7-17) años; el 78,9% eran mujeres. Las manifestaciones psiquiátricas fueron trastorno de ansiedad (52,6%), trastorno adaptativo y depresión (el 36,8% cada uno), psicosis (10%), trastorno conversivo (7,9%) y trastorno obsesivo compulsivo (5,3%). La puntuación SLICC media fue 2,76 ± 2,8 y la SLEDAI, 20,81 ± 20,82. Los anticuerpos antinucleares fueron positivos en el 81,25%. El 65,8% tenía diagnóstico de lupus neuropsiquiátrico, el 23,7% con crisis epilépticas, el 36,8% con cefalea, el 13,2% con accidente cerebrovascular, y vasculitis, corea y meningitis (el 5,3% cada una). El tiempo promedio desde el diagnóstico fue 20,47 ± 22,2 meses, mínimo para trastorno adaptativo (15 meses) y máximo para trastorno conversivo (seudocrisis) (31 meses). Los pacientes con psicosis presentaron las más altas puntuaciones de actividad lúpica (35,5 ± 16,21 frente a 19,08 ± 13,72; p = 0,032) y daño por la enfermedad (SLICC, 4,25 ± 4,03 frente a 2,58 ± 2,67; p = 0,27) en comparación con otros diagnósticos. Conclusiones: Las manifestaciones psiquiátricas más frecuentes fueron trastorno de ansiedad, adaptativo y depresión, con frecuencias mayores que lo reportado en otras poblaciones. Se demostró actividad lúpica principalmente en los pacientes con psicosis.(AU)

Objective: To describe the psychiatric manifestations in pediatric patients with systemic erythematous lupus seen in the Fundación Hospital de la Misericordia. Methods: Observational descriptive study. Medical charts and test results of inpatients and outpatients between 2007 and2013 were reviewed; 39 patients were selected. SPSS 19 was used for statistical analysis. Statistical significance was considered with P= .05. Results: Mean age was 13.7 (2.33), with 78.9% female. The most frequent psychiatric manifestation was anxiety (52.6%), followed by adjustment disorder and depression (36.8% each one), psychosis (10%), conversion disorder (7.9%), and obsessive compulsive disorder (5.3%). The mean SLICC score was 2.76 (2.8), and the mean SLEDAI score was 20.81 (20.82). Antinuclear antibodies were positive in 81.25%. Neuropsychiatric lupus was diagnosed in 65.8% of patients; seizures were observed in 23.7%, headache in 36.8%, stroke in 13.2%, vasculitis, chorea 5.3%, and meningitis 5.3% of patients. The mean time from lupus diagnosis was 20.47 (22.2) months, with the shortest period for adjustment disorder and the longest period in patients with conversion disorder (pseudo-seizures) being 15 months and 31 months, respectively. The highest SLEDAI score was in patients with psychosis (35.5 [16.21] vs 19.08 [13.72]; P = .032), and also the highest disease damage (SLICC, 4.25 [4.03] vs 2.58 [2.67]; P = .27) in comparison with the other manifestations. Conclusions: The most frequent psychiatric manifestations were anxiety, depression, and adjustment disorder, with a higher frequency than other studies, and with lupus activity principally in patients with psychosis.(AU)
Responsável: CO332 - Facultad de Medicina


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Id: 716871
Autor: Emmerick, Isabel Cristina Martins; Campos, Mônica Rodrigues; Schramm, Joyce Mendes de Andrade; Silva, Raulino Sabino da; Costa, Maria de Fátima dos Santos.
Título: Estimativas corrigidas de casos de meningite, Brasil 2008-2009 / Adjusted estimates of meningitis case, Brazil 2008-2009
Fonte: Epidemiol. serv. saúde;23(2):215-226, jun. 2014. tab, ilus.
Idioma: pt.
Resumo: Objetivo: descrever estimativas corrigidas para o número de casos de meningite no Brasil, unidades da federação (UF) e macrorregiões em 2008-2009. Métodos: a proposta de correção pautou-se na letalidade, considerando-se os casos no Sistema de Informação de Agravos de Notificação (Sinan) e os óbitos no Sistema de Informações sobre Mortalidade (SIM), em três etapas – (1) seleção dos casos Sinan; (2) compatibilização dos códigos no Sinan-SIM, com obtenção do número de óbitos do SIM; e (3) avaliação do sub-registro e aplicação de proposta de correção do Sinan. Resultados: originalmente, obteve-se 9.229 casos de meningites no Sinan; após correção de 32,9 por cento, estimou-se 12.261 casos para o Brasil em 2008-2009; encontrou-se grande variabilidade nas UF e por grupo de gravidade. Conclusão: verificou-se subnotificação de casos de meningite no Sinan, em relação ao SIM; ressalta-se a importância de estratégias para o fortalecimento dos sistemas de informação, como a capacitação dos profissionais de saúde. (AU)

Objective: to describe adjusted estimates of meningitis case numbers for Brazil, the Brazilian states and regions, 2008-2009. Methods: the estimates were adjusted based on the meningitis fatality rate taking cases reported on the Notifiable Diseases Information System (SINAN) and deaths reported on the Mortality Information System (SIM). The method involved three stages: 1) Selection of SINAN cases; 2) SINAN and SIM code matching and obtaining the number of deaths from the SIM system; 3) SINAN underreporting assessment and adjustment. Results: 9,229 meningitis cases were initially found on SINAN. After adjustment, 12,261 cases were estimated in Brazil, 2008-2009. Considerable variability was found between states and between groups of meningitis severity. Conclusion: meningitis cases were underreported on SINAN, compared to SIM. The importance of strategies for strengthening information systems is highlighted, such as health professional training. (AU)
Descritores: Meningite
Vigilância Epidemiológica
-Técnicas de Estimativa
Sistemas de Informação em Saúde/utilização
Limites: Humanos
Responsável: BR275.1 - Biblioteca



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