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Id: biblio-955483 LILACS-Express
Autor: Wermelinger, Eduardo Dias.
Título: Borrifar inseticidas de efeito residual para mitigar o risco da microcefalia causada pela zika
Fuente: Physis (Rio J.);28(3):e280303, 2018.
Idioma: pt.
Responsable: BR1.1 - BIREME


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Id: biblio-900370
Autor: Pacheco-Coral, Adriana del Pilar.
Título: Zika, Guillain-Barré y anestesiología: un punto de intersección entre la salud pública y la práctica clínica / Zika, Guillain-Barré and anesthesiology: A point of intersection between public health and clinical practice
Fuente: Rev. colomb. anestesiol;45(4):269-271, Oct.-Dec. 2017.
Idioma: en.
Resumo: Zika is a flavivirus transmitted by the Aedes spp. mosquito, characterized by an asymptomatic presentation in 80% of the cases. When symptoms develop, the primary manifestation is a macopapular rash. Zika is phylogenetically related to other viruses such as dengue, yellow fever, and West Nile. In Colombia, the endemic region for dengue and chikungunya is considered potentially endemic for Zika. The relevance of the virus lies in the associated neurological sequelae including microcephaly of the newborn, and Guillain-Barré syndrome in adults. Furthermore, in view of its re-emergence and association to these sequelae, Zika represents a medical challenge that goes beyond a public health concern, but involves other clinical specialties.
Descriptores: FREE ASSOCIATIONABBREVIATIONS AS TOPIC
Límites: Seres Humanos
Tipo de Publ: Editorial
Responsable: CO304.1 - Biblioteca Arturo Aparicio Jaramillo


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Id: biblio-882360
Autor: Romanelli, Roberta Maia de Castro; Carellos, Ericka Viana Machado; Lima, Mariana Antunes Faria; Diniz, Lilian Oliveira; Carvalho, Andrea Luchesi de; Wakabayashi, Eduarda Almeida; Souza, Tais Marina de; Ribeiro, Natalia Pinto; Nakaya, Camila; Oliveira, Gabriela Mafra de; Sacramento, João Paulo Tomaz da Cunha; Andrede, Gláucia Manzan de Queiroz.
Título: Estudo transversal do perfil das infecções congênitas atendidas entre 2012 e 2014 em um centro de referência em Belo Horizonte, Minas Gerais / Cross-sectional study of clinical and laboratorial aspects of congenital infections attended at a reference Center in Belo Horizonte, MG, 2012-2014
Fuente: Rev. méd. Minas Gerais;26(supl. 2):7-16, 2016. ilus, tab.
Idioma: pt.
Resumo: Introdução: as infecções congênitas são resultantes da transmissão vertical de microrganismos de gestantes infectadas para seus conceptos. Apesar dessas infecções, em geral, cursarem com pouca ou nenhuma manifestação clínica nas gestantes, a infecção fetal pode trazer morbimortalidade perinatal e na infância. Objetivo: identificar a prevalência das infecções congênitas encaminhadas ao Centro de Referência e Treinamento em Doenças Infecciosas e Parasitárias Orestes Diniz (CTR/DIP Orestes Diniz) e avaliar os métodos laboratoriais usados para o diagnóstico. Métodos: estudo transversal realizado em ambulatório de referência em doenças infecciosas, a partir de coleta de dados de prontuários de crianças com diagnóstico suspeito de infecção congênita. A confirmação diagnóstica baseou-se em testes sorológicos ou de biologia molecular, além de descrição de sintomatologia da criança. Resultados: um total de 513 crianças foram identificadas, sendo que 41,3% tiveram o diagnóstico confirmado, a maioria foi de toxoplasmose (45,35%) e sífilis (15,98%). Entre as crianças com diagnóstico confirmado, 28,85% apresentaram manifestações clínicas, enquanto que no grupo com diagnóstico indeterminado ou suspeito o percentual foi de 16,38%. As principais manifestações identificadas foram acometimento do sistema nervoso central (n=39) e alterações visuais (n=30). Conclusão: a confirmação de infecção foi definida em aproximadamente metade dos pacientes avaliados e a maioria das crianças foi assintomática ao nascimento. O pré-natal de qualidade e a propedêutica e tratamento precoce das crianças identificadas podem reduzir o impacto dessas infecções no nosso meio.(AU)

Introduction: congenital infections are results of microorganisms transmitted to the fetus by the infected pregnant. Most newborn infants infected during pregnancy or labor have no sings of congenital disease. However, these infections may cause perinatal and infancy morbidity and mortality. Objective: to determine the prevalence of congenital infections in newborns and infants attended at the CTR/DIP Orestes Diniz (Centro de Treinamento e Referência em Doenças Infecciosas e Parasitárias Orestes Diniz) and to analyse the laboratorial methods used for diagnosis of congenital disease of assisted children. Methods: cross-sectional study conducted in an Infectious Diseases Reference Center where it was evaluated the charts of infants with suspected congenital infection. Diagnosis confirmation was based on serological tests, molecular biology and signs and symptoms described in the charts. Results: A total of 41,3% of the 513 children identified have had a defined diagnosis. Most of them had toxoplasmosis (45,35%) and syphilis (15,98%). Clinical manifestations was observed in 28,85% of children with defined diagnosis of congenital infection, and in 16,38% of children with uncertain diagnosis. Central Nervous System (n=39) and ocular (n=30) manifestations were the most frequent findings. Conclusions: Defined diagnosis was possible in about half of cases and most of them were asymptomatic at birth. An appropriate prenatal care and early diagnosis and treatment of congenital infections may reduce the impact of disease in the population.(AU)
Descriptores: Sífilis Congénita
Toxoplasmosis Congénita
Dengue/congénito
Hepatitis B/congénito
Intercambio Materno-Fetal
-Brasil
Estudios Retrospectivos
Infecciones por Citomegalovirus
Fiebre Chikungunya/congénito
Infección por el Virus Zika/congénito
Antiinfecciosos/uso terapéutico
Límites: Seres Humanos
Responsable: BR21.1 - Biblioteca J Baeta Vianna- Campus Saúde UFMG


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Id: lil-783608
Autor: Pardo-Turriago, Rodrigo.
Título: Zika. Una pandemia en progreso y un reto epidemiológico / Zika. A pandemic in progress and an epidemiological challenge
Fuente: Rev. colomb. anestesiol;44(2):86-88, Apr.-June 2016.
Idioma: en.
Resumo: The recent Zika pandemic has become the focus of attention for multilateral health organizations, researchers in centres and universities, specialized publications, mass media, and in particular for populations where it is now a reality, and those that are potentially at risk.
Descriptores: FREE ASSOCIATIONABBREVIATIONS AS TOPIC
Límites: Seres Humanos
Tipo de Publ: Editorial
Responsable: CO332 - Facultad de Medicina


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Id: lil-783607
Autor: Acosta, Orlando.
Título: Virus de Zika: se expande su culpabilidad por asociación / Zika virus: Growing guilt from association
Fuente: Rev. colomb. anestesiol;44(2):83-85, Apr.-June 2016.
Idioma: en.
Resumo: The Zika virus (ZIKV) is part of the Flaviviridae family and is transmitted by mosquitoes of the Aedes genus, as is the case with other members of that family, including the dengue virus (DENV), the yellow fever virus (YFV), the Japanese encephalitis virus (JEV), and the Western Nile virus (WNV). The ZIKV genome consists of an RNA molecule (ribonucleic acid) that encodes for a polyprotein which, following processing, results in the production of three structural proteins (C, prM and E) and seven non-structural proteins (NS). Studies about its molecular evolution point to three main ZIKV lineages: one from Asia and two from Africa. Recent studies have shown that it has undergone several recombination events since it emerged in Uganda early in the 20th century, and then after it moved towards Western Africa and Asia. Phylogenetic tree analyses have shown that the Surinam ZIKV strains belong to the Asian genotype and are intimately related to the strain that circulated in the French Polynesia in 2014, with which they share 99.7% of the genetic information and 99.9% of their identity in the amino acid sequences that make up the protein.
Descriptores: FREE ASSOCIATIONABBREVIATIONS AS TOPIC
Límites: Seres Humanos
Tipo de Publ: Editorial
Responsable: CO332 - Facultad de Medicina


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Id: biblio-965743 LILACS-Express
Autor: Aguiar, Yêska Paola Costa; Cavalcanti, Alidianne Fábia Cabral; de Alencar, Catarina Ribeiro Barros; Melo, Adriana Suely de Oliveira; Cavalcanti, Sérgio d`Ávila Lins Bezerra; Cavalcanti, Alessandro Leite.
Título: Chronology of the First Deciduous Tooth Eruption in Brazilian Children with Microcephaly Associated with Zika Virus: A Longitudinal Study
Fuente: Pesqui. bras. odontopediatria clín. integr;18(1):3982, 15/01/2018.
Idioma: en.
Resumo: Objective: To analyze the chronology of first deciduous tooth eruption in children with microcephaly associated with presumed or confirmed Zika virus. Material and Methods: A longitudinal study was developed with 74 children of both sexes. Data on prematurity, gestational age (in weeks), anthropometric characteristics at birth [length (cm), weight (g) and cephalic perimeter (cm)] and dental eruption (chronological age and corrected age for prematurity in months) were collected and presented through descriptive statistics. Data was analyzed using the Statistical Package for Social Sciences. Results: The majority of children were female (54.1%) and 14.9% were born premature. The mean gestational age was 38.2 (± 1.9) weeks, while length, weight and cephalic perimeter at birth were 45.6 (± 3.1) cm, 2750 (± 526.6) and 30 (± 2.3) cm, respectively. The eruption of the first tooth occurred on average at 12.3 (± 3.0) months of chronological age and at 11.1 (± 2.3) months of corrected age. The first erupted teeth were the lower deciduous central incisors (82.4%). The mean age for dental eruption in males was 12.5 months (± 3.0) and in females 12.0 months (± 3.1) among full-term children. For premature infants, the mean corrected age of dental eruption was 11.5 months (± 3.4) for boys and 11 months (± 1.7) for girls. Conclusion: In this group of children with microcephaly, the first tooth to erupt was the lower central incisor around the first year of life. Girls had lower average eruption time when compared to boys in both chronological age and age corrected for prematurity.
Responsable: BR1822.9 - Associação de Apoio à Pesquisa em Saúde Bucal


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Id: biblio-963730
Autor: Perú. Ministerio de Salud; .Centro Nacional de Epidemiología; .Prevención y Control de Enfermedades.
Título: Norma Técnica de Salud para la vigilancia epidemiológica y diagnóstico de laboratorio de dengue, chikungunya, zika y otras arbovirosis en el Perú / Technical Health Standard for the epidemiological surveillance and laboratory diagnosis of dengue, chikungunya, zika and other arboviruses in Peru.
Fuente: Lima; Perú. Ministerio de Salud; 20160000. 52 p p. ilus..
Idioma: es.
Resumo: La presente Normativa Técnica de Salud es de aplicación obligatoria en todos los establecimientos prestadores de servicios de salud públicos, del Ministerio de Salud, del Instituto de Gestión de Servicios de Salud - IGSS, de los gobiernos regionales y gobiernos locales, Seguro Social de Salud (EsSALUD), de las sanidades de las Fuerzas Armadas, de la Policía Nacional del Perú y del Instituto Nacional Penitenciario; así como establecimientos del sector privado, clínicas, consultorios médicos particulares entre otros.
Descriptores: Infecciones por Arbovirus
-Virus Chikungunya
Virus Zika
Responsable: PE18.1 - Biblioteca Central


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Id: lil-782747
Autor: Reis, Raquel Pitchon dos.
Título: Surto de microcefalia no Brasil / Microcephaly outbreak in Brazil
Fuente: REME rev. min. enferm;19(4):812-814, out.-dez. 2015.
Idioma: pt.
Descriptores: Infección por el Virus Zika/mortalidad
Infección por el Virus Zika/transmisión
Infección por el Virus Zika/epidemiología
Microcefalia
-Brasil
Límites: Seres Humanos
Masculino
Femenino
Responsable: BR21.1 - Biblioteca J Baeta Vianna- Campus Saúde UFMG


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Id: lil-784141
Autor: Calderón-Arguedas, Ólger; Troyo, Adriana.
Título: Evaluación de la resistencia a insecticidas en cepas de Aedes aegypti (Diptera: Culicidae) de la Región Caribe de Costa Rica / Evaluation of insecticide resistance in strains of Aedes aegypti (Diptera: Culicidae) from the Caribbean region of Costa Rica
Fuente: Rev. cuba. med. trop;68(1):0-0, abr. 2016. tab.
Idioma: es.
Resumo: Introducción: el dengue y chikungunya son virosis antroponóticas transmitidas por Aedes aegypti que afectan extensas áreas del continente americano incluyendo Costa Rica. La reciente introducción del virus Zika representa un nuevo reto para los sistemas de salud. Dada la ausencia de tratamiento antiviral y vacunas, el control del vector Ae. aegypti, representa la única alternativa para minimizar el impacto de estas virosis. En Costa Rica, el control químico del vector se hace mediante la aplicación de piretroides (cipermetrina y deltametrina) y del organofosforado temefós; de ahí la importancia de detectar la aparición de resistencia a estos insecticidas. Objetivo: determinar el nivel de resistencia a temefós, cipermetrina y deltametrina en tres cepas de Ae. aegypti de la Región Caribe de Costa Rica, así como los mecanismos de detoxificación enzimática correspondientes. Métodos: la resistencia a temefós, cipermetrina y deltametrina se evaluó mediante bioensayos larvarios. Grupos de 20 larvas se expusieron por 24 h a 5 concentraciones de insecticidas que generaron una mortalidad entre el 2 y el 100 por ciento. Cada concentración se evaluó mediante cinco réplicas y se calculó la concentración que causa el 50 por ciento de letalidad (CL50). Como control susceptible se empleó la cepa Rockefeller. Con cada cepa se calculó un factor de resistencia 50 por ciento (FR50) para cada insecticida. Cuando se observó resistencia, se repitieron los bioensayos mediante exposición previa de las larvas a butóxido de piperonilo (PB) y S,S,S, tributilfosforotritioato (DEF) para evaluar el mecanismo detoxificante relacionado. Resultados: ninguna de las cepas evaluadas fue resistente al temefós. En las cepas Guápiles y Limón se determinó una resistencia incipiente a cipermetrina (CL50= 0,01022, FR50= 7,35 y CL 50= 0,01016, FR50= 7,30, respectivamente), mientras que en la cepa Siquirres se detectó resistencia a deltametrina (CL50= 0,01973 mg/L, FR5= 12,64). En los casos referidos hubo una disminución de la resistencia cuando se dio el pretratamiento con PB, lo que indica una detoxificación mediada por el sistema Cit P450 monooxigenasa. Conclusiones: los resultados en el presente estudio demuestran que el temefós sigue siendo efectivo para el control larvario de Ae. aegypti en las principales localidades de la región Caribe de Costa Rica. Con respecto a los piretroides se alerta ante la aparición de resistencia, lo que conlleva la necesidad de optimizar los procesos de monitoreo y la implementación de otras alternativas de control químico(AU)

Introduction: dengue and chikungunya are anthroponotic virus infections transmitted by Aedes aegypti mosquitoes. These conditions affect large areas of the American continent, including Costa Rica. The recent introduction of Zika virus infection is a new challenge for health systems. Given the absence of antiviral treatment and vaccines, Aedes aegypti control is the only alternative to minimize the impact of these viral diseases. In Costa Rica chemical control of the vector is based on the use of pyrethroids (cypermethrin and deltamethrin) and the organophosphate larvicide temephos, hence the importance of detecting the emergence of resistance to these insecticides. Objective: determine the level of resistance to temephos, cypermethrin and deltamethrin in three Aedes aegypti strains from the Caribbean region of Costa Rica, as well as the corresponding enzymatic detoxification mechanisms. Methods: resistance to temephos, cypermethrin and deltamethrin was evaluated with larval bioassays. Groups of 20 larvae were exposed to 5 insecticide concentrations for 24 h. Mortality ranged between 2 and 100 percent. Each concentration was evaluated by means of five replications, and estimation was performed of the concentration causing 50 percent lethality (CL50). The Rockefeller strain was used as susceptible control. Each strain underwent estimation of a 50 percent resistance factor (RF50) for each insecticide. Whenever resistance was observed, the bioaasays were repeated with prior exposure of the larvae to piperonyl butoxide (PBO) and S.S.S. phosphotrithiate tributyl (DEF) to evaluate the corresponding detoxification mechanism. Results: none of the strains evaluated was resistant to temephos. Incipient resistance to cypermethrin was detected in strains Guápiles and Limón (CL50= 0.01022, RF50= 7.35 and CL 50= 0.01016, RF50= 7.30, respectively), whereas resistance to deltamethrin was detected in the Siquirres strain (CL50= 0.01973 mg/L, RF50= 12.64). In the above-mentioned cases resistance decreased when pre-treatment with PBO was provided, indicating the presence of detoxification mediated by the Cyt P450 monooxygenase system. Conclusions: results show that temephos continues to be effective for larval control of Aedes aegypti in the main areas of the Caribbean region of Costa Rica. A warning is hereby given about the emergence of pyrethroid resistance, leading to the need to optimize monitoring processes and the implementation of other chemical control alternatives(AU)
Descriptores: Bioensayo/métodos
Resistencia a los Insecticidas
Aedes
-Temefós/uso terapéutico
Control de Vectores
Límites: Animales
Responsable: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-965193
Autor: Ponciano, Juan A; Chang, Juan D; Quiroa, Francisco.
Título: Modelo epidémico para el estudio regional de la chikungunya / Epidemic Model for the regional study of chikungunya
Fuente: Cienc. tecnol. salud;5(1):63-72, 2018. ilus.
Idioma: es.
Resumo: En el presente estudio planteamos un modelo matemático como marco cuantitativo para describir el brote epidémico de la enfermedad de chikungunya ocurrido en Guatemala durante las últimas semanas del 2014. El modelo pertenece a la familia de modelos compartimentales, introducidos inicialmente para el estudio epidemiológico de la malaria. Contiene los ingredientes básicos para describir la dinámica de transmisión del virus entre las poblaciones de humanos y mosquitos. El trabajo inicia con un análisis teórico cuyo objetivo es mostrar la estabilidad del modelo y explorar las posibilidades de equilibrio endémico y equilibrio libre de la infección en una población dada. Luego del análisis de estabilidad, se interpretó la incidencia semanal de humanos infectados predicha por el modelo como el valor esperado de las observaciones. Para ello se tomaron en cuenta los datos oficiales reportados durante el 2014 en las memorias epidemiológicas del Ministerio de Salud Pública y Asistencia Social de Guatemala (MSPAS), correspondientes a cuatro municipios del departamento de Escuintla. En cada caso, se realizó una simulación numérica, utilizando métodos estadísticos que permiten obtener el mejor ajuste de parámetros biológicos y poblacionales del modelo frente a los datos reportados por el MSPAS. La simulación permitió caracterizar los registros observados en cada localidad a la luz del modelo en discusión. Los métodos presentados en este trabajo podrían ser útiles como herramienta cuantitativa de apoyo para prever escenarios futuros sobre epidemias regionales de enfermedades ocasionadas por el Aedes aegypti, tales como el dengue, el zika y la chikungunya.

In the present study we propose a quantitative framework to describe the epidemic outbreak of chikungunya disease occurred in Guatemala during the last weeks of 2014. The model belongs to the family of compartmental models, initially introduced for the epidemiological study of malaria. It contains the basic ingredients to describe the dynamics of virus transmission between human and mosquito populations. The study begins with a theoretical analysis aimed at showing the stability of the model in order to explore the possibilities of endemic balance and free balance of the infection in a given population. Once the stable equilibrium points were identified, the weekly incidence of infected humans estimated by the model was considered as the expected value of the observations. To this end, the official data reported during 2014 by the Ministry of Public Health and Social Assistance of Guatemala (MSPAS), corresponding to four municipalities in the department of Escuintla were taken into account. In each case, a numerical simulation was performed using statistical methods that allow obtaining the best fit of biological and population parameters of the model compared to the data reported by the MSPAS. The simulation enables to characterize the records observed in each locality on the grounds of the model under discussion. The quantitative methods presented in this paper could be useful for predicting.
Descriptores: Enfermedades Transmisibles/epidemiología
Epidemiología y Bioestadística
Fiebre Chikungunya/epidemiología
Guatemala/epidemiología
Límites: Femenino
Responsable: GT49.1



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