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[PMID]:29094370
[Au] Autor:Chan Seay R; Koroma AP; Coleman J; Sampson J; Koroma L; Ugwa EA; Anderson J
[Ad] Dirección:Johns Hopkins University School of Medicine, Department of Gynecology and Obstetrics, Baltimore, MD, USA.
[Ti] Título:Post-Ebola situational assessment of opportunities for capacity building at the national obstetrics and gynecology referral hospital in Sierra Leone.
[So] Fuente:Int J Gynaecol Obstet;, 2017 Nov 02.
[Is] ISSN:1879-3479
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:OBJECTIVE: To describe a site assessment of the Princess Christian Maternity Hospital (PCMH; Freetown, Sierra Leone), the national referral center for reproductive, maternal, newborn, child and adolescent health (RMNCAH) services and logical site for focused efforts to train and expand the RMNCAH workforce in Sierra Leone. METHODS: In April 2016, a mixed-methods assessment approach was used involving facility observation and staff interviews using the WHO's Service Availability and Readiness Assessment (SARA) tool. Quantitative and qualitative data were obtained. RESULTS: PCMH had 150 inpatient beds and provided care for more than 4600 deliveries in 2015. The number of maternal deaths increased at a rate of approximately 40% per month from January 2015 to June 2016 (P=0.005). Key factors requiring attention were identified in the categories of infrastructure and supplies, RMNCAH services, and human resources. CONCLUSION: SARA provided a framework for identifying strengths and weaknesses in infrastructure and supplies, RMNCAH services, and human resources. The process described might serve as a model for evaluating obstetrics and gynecology training facilities in low- and middle-income countries. Human resources are currently insufficient for the volume and complexity of patients at PCMH. Numerous opportunities exist for strengthening healthcare services and capacity building in Sierra Leone. This article is protected by copyright. All rights reserved.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1711
[Cu] Fecha actualización por clase:171102
[Lr] Fecha última revisión:171102
[St] Status:Publisher
[do] DOI:10.1002/ijgo.12374


  2 / 6876 MEDLINE  
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[PMID]:29093311
[Au] Autor:Kutsuna S; Yamamoto K; Takeshita N; Hayakawa K; Kato Y; Kanagawa S; Sugiki Y; Ohmagari N
[Ad] Dirección:Disease Control and Prevention Center, National Center for Global health and Medicine.
[Ti] Título:Experiences of response measures against the 4 suspected cases of ebola virus disease from West Africa in the National Center for Global Health and Medicine, Tokyo, Japan.
[So] Fuente:Jpn J Infect Dis;, 2017 Oct 31.
[Is] ISSN:1884-2836
[Cp] País de publicación:Japan
[La] Idioma:eng
[Ab] Resumen:In Japan, infectious diseases are classified into 4 types based on how contagious and severe the pathogens are, and Ebola virus disease (EVD) is categorized as a category 1 infectious disease. National Center for Global Health and Medicine in Tokyo, Japan, is designated as a specified hospital for category 1 infectious disease patients, and has experienced 4 probable cases of EVD from West Africa. Even after the end of the outbreak in West Africa, we should continue to pay attention for new EVD outbreaks. To increase the number of the infectious disease specialist with the proper knowledge of viral hemorrhagic fever including EVD is a common problem for infectious disease physicians working in Japan, the academic society, and the government.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1711
[Cu] Fecha actualización por clase:171102
[Lr] Fecha última revisión:171102
[St] Status:Publisher
[do] DOI:10.7883/yoken.JJID.2016.508


  3 / 6876 MEDLINE  
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[PMID]:29085841
[Au] Autor:Kortepeter MG; Cieslak TJ; Kwon EH; Smith PW; Kratochvil CJ; Hewlett AL
[Ad] Dirección:Medical Division, Laulima Government Solutions, Orlando, FL, USA.
[Ti] Título:Comment on "Ebola Virus Infection among Western Healthcare Workers Unable to Recall the Transmission Route".
[So] Fuente:Biomed Res Int;2017:7458242, 2017.
[Is] ISSN:2314-6141
[Cp] País de publicación:United States
[La] Idioma:eng
[Pt] Tipo de publicación:JOURNAL ARTICLE; COMMENT
[Em] Mes de ingreso:1710
[Cu] Fecha actualización por clase:171102
[Lr] Fecha última revisión:171102
[St] Status:In-Data-Review
[do] DOI:10.1155/2017/7458242


  4 / 6876 MEDLINE  
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[PMID]:28991915
[Au] Autor:Hagel C; Weidemann F; Gauch S; Edwards S; Tinnemann P
[Ad] Dirección:Institute for Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin Berlin, Berlin, Germany.
[Ti] Título:Analysing published global Ebola Virus Disease research using social network analysis.
[So] Fuente:PLoS Negl Trop Dis;11(10):e0005747, 2017 Oct.
[Is] ISSN:1935-2735
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:INTRODUCTION: The 2014/2015 West African Ebola Virus Disease (EVD) outbreak attracted global attention. Numerous opinions claimed that the global response was impaired, in part because, the EVD research was neglected, although quantitative or qualitative studies did not exist. Our objective was to analyse how the EVD research landscape evolved by exploring the existing research network and its communities before and during the outbreak in West Africa. METHODS/ PRINCIPAL FINDINGS: Social network analysis (SNA) was used to analyse collaborations between institutions named by co-authors as affiliations in publications on EVD. Bibliometric data of publications on EVD between 1976 and 2015 was collected from Thomson Reuters' Web of Science Core Collection (WoS). Freely available software was used for network analysis at a global-level and for 10-year periods. The networks are presented as undirected-weighted graphs. Rankings by degree and betweenness were calculated to identify central and powerful network positions; modularity function was used to identify research communities. Overall 4,587 publications were identified, of which 2,528 were original research articles. Those yielded 1,644 authors' affiliated institutions and 9,907 connections for co-authorship network construction. The majority of institutions were from the USA, Canada and Europe. Collaborations with research partners on the African continent did exist, but less frequently. Around six highly connected organisations in the network were identified with powerful and broker positions. Network characteristics varied widely among the 10-year periods and evolved from 30 to 1,489 institutions and 60 to 9,176 connections respectively. Most influential actors are from public or governmental institutions whereas private sector actors, in particular the pharmaceutical industry, are largely absent. CONCLUSION/ SIGNIFICANCE: Research output on EVD has increased over time and surged during the 2014/2015 outbreak. The overall EVD research network is organised around a few key actors, signalling a concentration of expertise but leaving room for increased cooperation with other institutions especially from affected countries. Finding innovative ways to maintain support for these pivotal actors while steering the global EVD research network towards an agenda driven by agreed, prioritized needs and finding ways to better integrate currently peripheral and newer expertise may accelerate the translation of research into the development of necessary live saving products for EVD ahead of the next outbreak.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1710
[Cu] Fecha actualización por clase:171102
[Lr] Fecha última revisión:171102
[St] Status:In-Process
[do] DOI:10.1371/journal.pntd.0005747


  5 / 6876 MEDLINE  
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[PMID]:28878074
[Au] Autor:Rizk MG; Basler CF; Guatelli J
[Ad] Dirección:University of California San Diego, La Jolla, California, USA.
[Ti] Título:Cooperation of the Ebola Virus Proteins VP40 and GP with BST2 To Activate NF-κB Independently of Virus-Like Particle Trapping.
[So] Fuente:J Virol;91(22), 2017 Nov 15.
[Is] ISSN:1098-5514
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:BST2 is a host protein with dual functions in response to viral infections: it traps newly assembled enveloped virions at the plasma membrane in infected cells, and it induces NF-κB activity, especially in the context of retroviral assembly. In this study, we examined whether Ebola virus proteins affect BST2-mediated induction of NF-κB. We found that the Ebola virus matrix protein, VP40, and envelope glycoprotein, GP, each cooperate with BST2 to induce NF-κB activity, with maximal activity when all three proteins are expressed. Unlike human immunodeficiency virus type 1 Vpu protein, which antagonizes both virion entrapment and the activation of NF-κB by BST2, Ebola virus GP does not inhibit NF-κB signaling even while it antagonizes the entrapment of virus-like particles. GP from Reston ebolavirus, a nonpathogenic species in humans, showed a phenotype similar to that of GP from Zaire ebolavirus, a highly pathogenic species, in terms of both the activation of NF-κB and the antagonism of virion entrapment. Although Ebola virus VP40 and GP both activate NF-κB independently of BST2, VP40 is the more potent activator. Activation of NF-κB by the Ebola virus proteins either alone or together with BST2 requires the canonical NF-κB signaling pathway. Mechanistically, the maximal NF-κB activation by GP, VP40, and BST2 together requires the ectodomain cysteines needed for BST2 dimerization, the putative BST2 tetramerization residue L70, and Y6 of a potential hemi-ITAM motif in BST2's cytoplasmic domain. BST2 with a glycosylphosphatidylinositol (GPI) anchor signal deletion, which is not expressed at the plasma membrane and is unable to entrap virions, activated NF-κB in concert with the Ebola virus proteins at least as effectively as wild-type BST2. Signaling by the GPI anchor mutant also depended on Y6 of BST2. Overall, our data show that activation of NF-κB by BST2 is independent of virion entrapment in the case of Ebola virus. Nonetheless, BST2 may induce or amplify proinflammatory signaling during Ebola virus infection, potentially contributing to the dysregulated cytokine response that is a hallmark of Ebola virus disease. Understanding how the host responds to viral infections informs the development of therapeutics and vaccines. We asked how proinflammatory signaling by the host protein BST2/tetherin, which is mediated by the transcription factor NF-κB, responds to Ebola virus proteins. Although the Ebola virus envelope glycoprotein (GP ) antagonizes the trapping of newly formed virions at the plasma membrane by BST2, we found that it does not inhibit BST2's ability to induce NF-κB activity. This distinguishes GP from the HIV-1 protein Vpu, the prototype BST2 antagonist, which inhibits both virion entrapment and the induction of NF-κB activity. Ebola virus GP , the Ebola virus matrix protein VP40, and BST2 are at least additive with respect to the induction of NF-κB activity. The effects of these proteins converge on an intracellular signaling pathway that depends on a protein modification termed neddylation. Better mechanistic understanding of these phenomena could provide targets for therapies that modulate the inflammatory response during Ebola virus disease.
[Mh] Términos MeSH primario: Antígenos CD/metabolismo
Ebolavirus/metabolismo
FN-kappa B/metabolismo
Proteínas del Envoltorio Viral/metabolismo
Proteínas de la Matriz Viral/metabolismo
Virión/metabolismo
[Mh] Términos MeSH secundario: Secuencias de Aminoácidos
Antígenos CD/genética
Membrana Celular/genética
Membrana Celular/metabolismo
Membrana Celular/virología
Ebolavirus/genética
Proteínas Ligadas a GPI/genética
Proteínas Ligadas a GPI/metabolismo
Células HEK293
Humanos
FN-kappa B/genética
Dominios de Proteínas
Multimerización de Proteína
Proteínas del Envoltorio Viral/genética
Proteínas de la Matriz Viral/genética
Virión/genética
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Antigens, CD); 0 (BST2 protein, human); 0 (GPI-Linked Proteins); 0 (NF-kappa B); 0 (VP40 protein, virus); 0 (Viral Envelope Proteins); 0 (Viral Matrix Proteins); 0 (envelope glycoprotein, Ebola virus)
[Em] Mes de ingreso:1711
[Cu] Fecha actualización por clase:171102
[Lr] Fecha última revisión:171102
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170907
[St] Status:MEDLINE


  6 / 6876 MEDLINE  
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[PMID]:28804092
[Au] Autor:Hengjan Y; Iida K; Doysabas KCC; Phichitrasilp T; Ohmori Y; Hondo E
[Ad] Dirección:Laboratory of Animal Morphology, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan.
[Ti] Título:Diurnal behavior and activity budget of the golden-crowned flying fox (Acerodon jubatus) in the Subic bay forest reserve area, the Philippines.
[So] Fuente:J Vet Med Sci;79(10):1667-1674, 2017 Oct 07.
[Is] ISSN:1347-7439
[Cp] País de publicación:Japan
[La] Idioma:eng
[Ab] Resumen:Acerodon jubatus (the Golden-Crowned flying fox) is an endemic species in the Philippines, which was suspected to be a host of the Reston strain of the Ebola virus. As nocturnal animals, the flying foxes spend daytime at the roosting site, which they use for self-maintenance and reproduction. To understand the variation in diurnal behavior and time allocation for various activities in the Golden-Crowned flying fox, we investigated their daytime behavior and activity budget using instantaneous scan sampling and all occurrence focal sampling. Data collection was performed from 07:00 to 18:00 hr during January 8-17, 2017. The most frequent activity was sleeping (76.3%). The remaining activities were wing flapping (5.0%), self-grooming (4.2%), hanging relaxation (3.4%), wing spread (2.9%), movement (2.4%), mating/courtship (2.4%), aggression (1.9%), hanging alert (1.2%), excretion (0.1%) and scent marks (0.05%). The frequency of sleeping, wing flapping, self-grooming, hanging relaxation, aggression, mating/courtship and movement behaviors changed with the time of the day. Females allocated more time for resting than males, while males spent more time on the activities that helped enhance their mating opportunities, for example, movement, sexual activity and territorial behavior.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1708
[Cu] Fecha actualización por clase:171102
[Lr] Fecha última revisión:171102
[St] Status:In-Process
[do] DOI:10.1292/jvms.17-0329


  7 / 6876 MEDLINE  
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[PMID]:28799905
[Au] Autor:Crowe JE
[Ad] Dirección:Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address: james.crowe@vanderbilt.edu.
[Ti] Título:Principles of Broad and Potent Antiviral Human Antibodies: Insights for Vaccine Design.
[So] Fuente:Cell Host Microbe;22(2):193-206, 2017 Aug 09.
[Is] ISSN:1934-6069
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Antibodies are the principal immune effectors that mediate protection against reinfection following viral infection or vaccination. Robust techniques for human mAb isolation have been developed in the last decade. The study of human mAbs isolated from subjects with prior immunity has become a mainstay for rational structure-based, next-generation vaccine development. The plethora of detailed molecular and genetic studies coupling the structure of antigen-antibody complexes with their antiviral function has begun to reveal common principles of critical interactions on which we can build better vaccines and therapeutic antibodies. This review outlines the approaches to isolating and studying human antiviral mAbs and discusses the common principles underlying the basis for their activity. This review also examines progress toward the goal of achieving a comprehensive understanding of the chemical and physical basis for molecular recognition of viral surface proteins in order to build predictive molecular models that can be used for vaccine design.
[Pt] Tipo de publicación:JOURNAL ARTICLE; REVIEW
[Em] Mes de ingreso:1708
[Cu] Fecha actualización por clase:171103
[Lr] Fecha última revisión:171103
[St] Status:In-Process


  8 / 6876 MEDLINE  
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[PMID]:28673681
[Au] Autor:Fogel I; David O; Balik CH; Eisenkraft A; Poles L; Shental O; Kassirer M; Brosh-Nissimov T
[Ad] Dirección:Israel Defense Forces Medical Corps, Haifa, Israel.
[Ti] Título:The association between self-perceived proficiency of personal protective equipment and objective performance: An observational study during a bioterrorism simulation drill.
[So] Fuente:Am J Infect Control;45(11):1238-1242, 2017 Nov 01.
[Is] ISSN:1527-3296
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:BACKGROUND: The recent Ebola virus disease outbreak emphasized the potential misuse of personal protective equipment (PPE) by health care workers (HCWs) during such an event. We aimed to compare self-perceived proficiency of PPE use and objective performance, and identify predictors of low compliance and PPE misuse. METHODS: An observational study combined with subjective questionnaires were carried out during a bioterror simulation drill. Forty-two observers evaluated performance under PPE. Mistakes were recorded and graded using a structured observational format and were correlated with the subjective questionnaires and with demographic parameters. RESULTS: One hundred seventy-eight HCWs from community clinics and hospitals were included. The mean self-perceived proficiency was high (6.1 out of 7), mean level of comfort was moderate (4.0 out of 7), and mean objective performance was intermediate (9.5 out of 13). There was no correlation between comfort and objective performance scores. Self-perceived proficiency was in correlation with donning and continuous performance with PPE but not with doffing. Clinic personnel performed better than personnel in hospitals (40.3% vs 67.8% with 3 or more mistakes, respectively; P = .001). Demographic characteristics had no correlation with objective or self-perceived performance. CONCLUSIONS: Self-perceived proficiency is a poor predictor of appropriate PPE use. The results suggest poor awareness of the possibility of PPE misuse.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1707
[Cu] Fecha actualización por clase:171103
[Lr] Fecha última revisión:171103
[St] Status:In-Process


  9 / 6876 MEDLINE  
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[PMID]:28645623
[Au] Autor:Cheng H; Schafer A; Soloveva V; Gharaibeh D; Kenny T; Retterer C; Zamani R; Bavari S; Peet NP; Rong L
[Ad] Dirección:Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA. Electronic address: hancheng@uic.edu.
[Ti] Título:Identification of a coumarin-based antihistamine-like small molecule as an anti-filoviral entry inhibitor.
[So] Fuente:Antiviral Res;145:24-32, 2017 Sep.
[Is] ISSN:1872-9096
[Cp] País de publicación:Netherlands
[La] Idioma:eng
[Ab] Resumen:Filoviruses, consisting of Ebola virus, Marburg virus and Cuevavirus, cause severe hemorrhagic fevers in humans with high mortality rates up to 90%. Currently, there is no approved vaccine or therapy available for the prevention and treatment of filovirus infection in humans. The recent 2013-2015 West African Ebola epidemic underscores the urgency to develop antiviral therapeutics against these infectious diseases. Our previous study showed that GPCR antagonists, particularly histamine receptor antagonists (antihistamines) inhibit Ebola and Marburg virus entry. In this study, we screened a library of 1220 small molecules with predicted antihistamine activity, identified multiple compounds with potent inhibitory activity against entry of both Ebola and Marburg viruses in human cancer cell lines, and confirmed their anti-Ebola activity in human primary cells. These small molecules target a late-stage of Ebola virus entry. Further structure-activity relationship studies around one compound (cp19) reveal the importance of the coumarin fused ring structure, especially the hydrophobic substituents at positions 3 and/or 4, for its antiviral activity, and this identified scaffold represents a favorable starting point for the rapid development of anti-filovirus therapeutic agents.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1706
[Cu] Fecha actualización por clase:171103
[Lr] Fecha última revisión:171103
[St] Status:In-Process


  10 / 6876 MEDLINE  
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[PMID]:28018915
[Au] Autor:Petti S; Protano C; Messano GA; Scully C
[Ad] Dirección:Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy.
[Ti] Título:Ebola Virus Infection among Western Healthcare Workers Unable to Recall the Transmission Route.
[So] Fuente:Biomed Res Int;2016:8054709, 2016.
[Is] ISSN:2314-6141
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:During the 2014-2016 West-African Ebola virus disease (EVD) outbreak, some HCWs from Western countries became infected despite proper equipment and training on EVD infection prevention and control (IPC) standards. Despite their high awareness toward EVD, some of them could not recall the transmission routes. We explored these incidents by recalling the stories of infected Western HCWs who had no known directly exposures to blood/bodily fluids from EVD patients. We carried out conventional and unconventional literature searches through the web using the keyword "Ebola" looking for interviews and reports released by the infected HCWs and/or the healthcare organizations. We identified fourteen HCWs, some infected outside West Africa and some even classified at low EVD risk. None of them recalled accidents, unintentional exposures, or any IPC violation. Infection transmission was thus inexplicable through the acknowledged transmission routes. We formulated two hypotheses: inapparent exposures to blood/bodily fluids or transmission due to asymptomatic/mildly symptomatic carriers. This study is in no way intended to be critical with the healthcare organizations which, thanks to their interventions, put an end to a large EVD outbreak that threatened the regional and world populations.
[Mh] Términos MeSH primario: Brotes de Enfermedades
Personal de Salud
Enfermedad por el Virus de Ebola/transmisión
[Mh] Términos MeSH secundario: África Occidental/epidemiología
Femenino
Enfermedad por el Virus de Ebola/mortalidad
Enfermedad por el Virus de Ebola/virología
Humanos
Masculino
[Pt] Tipo de publicación:JOURNAL ARTICLE; REVIEW
[Em] Mes de ingreso:1701
[Cu] Fecha actualización por clase:171102
[Lr] Fecha última revisión:171102
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:161226
[St] Status:MEDLINE
[do] DOI:10.1155/2016/8054709



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