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  1 / 3468 MEDLINE  
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[PMID]:29099491
[Au] Autor:Pan X; Pike A; Joshi D; Bian G; McFadden MJ; Lu P; Liang X; Zhang F; Raikhel AS; Xi Z
[Ad] Dirección:Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.
[Ti] Título:The bacterium Wolbachia exploits host innate immunity to establish a symbiotic relationship with the dengue vector mosquito Aedes aegypti.
[So] Fuente:ISME J;, 2017 Nov 03.
[Is] ISSN:1751-7370
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:A host's immune system plays a central role in shaping the composition of the microbiota and, in return, resident microbes influence immune responses. Symbiotic associations of the maternally transmitted bacterium Wolbachia occur with a wide range of arthropods. It is, however, absent from the dengue and Zika vector mosquito Aedes aegypti in nature. When Wolbachia is artificially forced to form symbiosis with this new mosquito host, it boosts the basal immune response and enhances the mosquito's resistance to pathogens, including dengue, Zika virus and malaria parasites. The mechanisms involved in establishing a symbiotic relationship between Wolbachia and A. aegypti, and the long-term outcomes of this interaction, are not well understood. Here, we have demonstrated that both the immune deficiency (IMD) and Toll pathways are activated by the Wolbachia strain wAlbB upon its introduction into A. aegypti. Silencing the Toll and IMD pathways via RNA interference reduces the wAlbB load. Notably, wAlbB induces peptidoglycan recognition protein (PGRP)-LE expression in the carcass of A. aegypti, and its silencing results in a reduction of symbiont load. Using transgenic mosquitoes with stage-specific induction of the IMD and Toll pathways, we have shown that elevated wAlbB infection in these mosquitoes is maintained via maternal transmission. These results indicate that host innate immunity is utilized to establish and promote host-microbial symbiosis. Our results will facilitate a long-term projection of the stability of the Wolbachia-A. aegypti mosquito system that is being developed to control dengue and Zika virus transmission to humans.The ISME Journal advance online publication, 3 November 2017; doi:10.1038/ismej.2017.174.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1711
[Cu] Fecha actualización por clase:171103
[Lr] Fecha última revisión:171103
[St] Status:Publisher
[do] DOI:10.1038/ismej.2017.174


  2 / 3468 MEDLINE  
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[PMID]:29097635
[Au] Autor:Luplertlop N; Suwanmanee S; Muangkaew W; Ampawong S; Kitisin T; Poovorawan Y
[Ad] Dirección:Department of Microbiology and Immunology, Mahidol University, Bangkok.
[Ti] Título:The impact of Zika virus infection on human neuroblastoma (SH-SY5Y) cell line.
[So] Fuente:J Vector Borne Dis;54(3):207-214, 2017 Jul-Sep.
[Is] ISSN:0972-9062
[Cp] País de publicación:India
[La] Idioma:eng
[Ab] Resumen:BACKGROUND & OBJECTIVES: An increase in Zika virus (ZIKV) epidemic during the last decade has become a major global concern as the virus affects both newborns and adult humans. Earlier studies have shown the impact of ZIKV infection in developing human foetus. However, effective in vitro model of target cells for studying the ZIKV infection in adult human neurons is not available. This study aimed to establish the use of human neuroblastoma cell line (SH-SY5Y) for studying an infection of ZIKV in vitro. METHODS: ZIKV growth kinetics, viral toxicity, and SH-SY5Y cell vialibity were determined after ZIKV infection in SH-SY5Y cells in vitro. ZIKV-infected SH-SY5Y cells were morphologically analysed and compared with nonhuman primate Vero cells. Furthermore, the susceptibility of SH-SY5Y cells to ZIKV infection was also determined. RESULTS: The results showed that ZIKV efficiently infects SH-SY5Y cell lines in vitro. Gradual changes of several cellular homeostasis parameters including cell viability, cytotoxicity, and cell morphology were observed in ZIKVinfected SH-SY5Y cells when compared to mock-treated or non-human primate cells. Interestingly, ZIKV particles were detected in the nucleoplasmic compartment of the infected SH-SY5Y cells. INTERPRETATION & CONCLUSION: The results suggest that ZIKV particle can be detected in the nucleoplasmic compartment of the infected SH-SY5Y cells beside the known viral replicating cytoplasmic area. Hence, SH-SY5Y cells can be used as an in vitro adult human neuronal cell-based model, for further elucidating the ZIKV biology, and highlight other possible significance of Zika virus distribution through nuclear localization, which may correlate to the neuropathological defects in ZIKV-infected adult humans.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1711
[Cu] Fecha actualización por clase:171103
[Lr] Fecha última revisión:171103
[St] Status:In-Process


  3 / 3468 MEDLINE  
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[PMID]:29097548
[Au] Autor:Guardado-Calvo P; Atkovska K; Jeffers SA; Grau N; Backovic M; Pérez-Vargas J; de Boer SM; Tortorici MA; Pehau-Arnaudet G; Lepault J; England P; Rottier PJ; Bosch BJ; Hub JS; Rey FA
[Ad] Dirección:Institut Pasteur, Département de Virologie, Unité de Virologie Structurale, 75724 Paris Cedex 15, France. pablo.guardado-calvo@pasteur.fr jhub@gwdg.de felix.rey@pasteur.fr.
[Ti] Título:A glycerophospholipid-specific pocket in the RVFV class II fusion protein drives target membrane insertion.
[So] Fuente:Science;358(6363):663-667, 2017 Nov 03.
[Is] ISSN:1095-9203
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:The Rift Valley fever virus (RVFV) is transmitted by infected mosquitoes, causing severe disease in humans and livestock across Africa. We determined the x-ray structure of the RVFV class II fusion protein Gc in its postfusion form and in complex with a glycerophospholipid (GPL) bound in a conserved cavity next to the fusion loop. Site-directed mutagenesis and molecular dynamics simulations further revealed a built-in motif allowing en bloc insertion of the fusion loop into membranes, making few nonpolar side-chain interactions with the aliphatic moiety and multiple polar interactions with lipid head groups upon membrane restructuring. The GPL head-group recognition pocket is conserved in the fusion proteins of other arthropod-borne viruses, such as Zika and chikungunya viruses, which have recently caused major epidemics worldwide.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1711
[Cu] Fecha actualización por clase:171103
[Lr] Fecha última revisión:171103
[St] Status:In-Data-Review
[do] DOI:10.1126/science.aal2712


  4 / 3468 MEDLINE  
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Wilson, Donald
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[PMID]:29097124
[Au] Autor:Darbellay J; Cox B; Lai K; Delgado-Ortega M; Wheler C; Wilson D; Walker S; Starrak G; Hockley D; Huang Y; Mutwiri G; Potter A; Gilmour M; Safronetz D; Gerdts V; Karniychuk U
[Ad] Dirección:Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-InterVac), University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada.
[Ti] Título:Zika Virus Causes Persistent Infection in Porcine Conceptuses and may Impair Health in Offspring.
[So] Fuente:EBioMedicine;, 2017 Sep 21.
[Is] ISSN:2352-3964
[Cp] País de publicación:Netherlands
[La] Idioma:eng
[Ab] Resumen:Outcomes of Zika virus (ZIKV) infection in pregnant women vary from the birth of asymptomatic offspring to abnormal development and severe brain lesions in fetuses and infants. There are concerns that offspring affected in utero and born without apparent symptoms may develop mental illnesses. Therefore, animal models are important to test interventions against in utero infection and health sequelae in symptomatic and likely more widespread asymptomatic offspring. To partially reproduce in utero infection in humans, we directly inoculated selected porcine conceptuses with ZIKV. Inoculation resulted in rapid trans-fetal infections, persistent infection in conceptuses, molecular pathology in fetal brains, fetal antibody and type I interferon responses. Offspring infected in utero showed ZIKV in their fetal membranes collected after birth. Some in utero affected piglets were small, depressed, had undersized brains, and showed seizures. Some piglets showed potentially increased activity. Our data suggest that porcine model of persistent in utero ZIKV infection has a strong potential for translational research and can be used to test therapeutic interventions in vivo.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1711
[Cu] Fecha actualización por clase:171103
[Lr] Fecha última revisión:171103
[St] Status:Publisher


  5 / 3468 MEDLINE  
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[PMID]:29096677
[Au] Autor:Di Luca M; Toma L; Severini F; Boccolini D; D'Avola S; Todaro D; Stancanelli A; Antoci F; La Russa F; Casano S; Sotera SD; Carraffa E; Versteirt V; Schaffner F; Romi R; Torina A
[Ad] Dirección:Department of Infectious Diseases, Unit of Vectorborne Diseases, Istituto Superiore di Sanità, Rome, Italy. marco.diluca@iss.it.
[Ti] Título:First record of the invasive mosquito species Aedes (Stegomyia) albopictus (Diptera: Culicidae) on the southernmost Mediterranean islands of Italy and Europe.
[So] Fuente:Parasit Vectors;10(1):543, 2017 Nov 02.
[Is] ISSN:1756-3305
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:BACKGROUND: Aedes albopictus, a known worldwide vector of several mosquito-borne disease pathogens including dengue, chikungunya and Zika viruses, was introduced into Europe in the late 1970s through global trade. First recorded in northern Italy in 1990, this mosquito species has rapidly spread throughout the country, where it was responsible for an outbreak of chikungunya in 2007 that affected more than 200 people. As part of the VectorNet project, which is aimed at improving preparedness and responsiveness for animal and human vector-borne diseases in Europe, a mosquito targeted study was carried out on the three southernmost Italian islands. The objective was to verify the current European southern distribution limits of Ae. albopictus and the potential occurrence of other invasive mosquito species, in the light of the introduction of high risk for vector-borne disease pathogens into Europe via migration flows. RESULTS: In the summer 2015, six surveys for container-breeding mosquitoes were carried out by setting up a network of oviposition traps and BG Sentinel traps in selected areas on the islands of Pantelleria, Lampedusa and Linosa. Aedes albopictus was found on all three islands under investigation. The consequences on public health with regard to the presence of this mosquito vector and the migrant people entering the country from Africa and the Middle East are also discussed here. CONCLUSIONS: The detection of the Asian tiger mosquito on these islands, which represent the last European strip of land facing Africa, has important implications for public health policy and should prompt the national authorities to implement tailored surveillance activities and reinforce plans for preparedness strategies in such contexts.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1711
[Cu] Fecha actualización por clase:171103
[Lr] Fecha última revisión:171103
[St] Status:In-Process
[do] DOI:10.1186/s13071-017-2488-7


  6 / 3468 MEDLINE  
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[PMID]:29096380
[Au] Autor:Singh A; Jana NK
[Ad] Dirección:Department of Biotechnology, Heritage Institute of Technology, Kolkata 700107, India. Electronic address: anjalibiotech123@gmail.com.
[Ti] Título:Discovery of potential Zika virus RNA polymerase inhibitors by docking-based virtual screening.
[So] Fuente:Comput Biol Chem;71:144-151, 2017 Oct 24.
[Is] ISSN:1476-928X
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Zika virus (ZIKV) infection has been associated with Guillain-Barre syndrome in adults and microcephaly in infants. The existence of insufficient structural data in most of the protein databases hinders the synthesis of anti-ZIKV pharmaceutics. In this work, we attempted to model the catalytic domain of the ZIKV RNA polymerase (RdRpC) along with a detailed assessment of conserved aspartates in ZIKV RdRpC palm domain as potential drug targets. The conserved and catalytically active aspartate residues present in the predicted RdRpC protein were virtually screened against a ZINC database for inhibitors, and the selected potential drug candidates were further filtered based on their ADMET profiles. One of the pharmacokinetically active compounds (Ligand 6) showed a remarkable docking profile against the strictly conserved aspartate residues of the RdRpC active site. We hypothesize that the Ligand 6 may form a potential drug candidate for RdRpC inhibition in the clinical treatment of ZIKV infection.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1711
[Cu] Fecha actualización por clase:171102
[Lr] Fecha última revisión:171102
[St] Status:Publisher


  7 / 3468 MEDLINE  
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[PMID]:29096005
[Au] Autor:Perry H; Khalil A; Aarons E; Russell K; O'Brien P
[Ad] Dirección:Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
[Ti] Título:Management of Zika virus in pregnancy: a review.
[So] Fuente:Br Med Bull;:1-13, 2017 Oct 31.
[Is] ISSN:1471-8391
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Introduction/background: Since 2015, an epidemic of Zika virus spread across the Americas. This coincided with an increased incidence of microcephaly reported at birth in Brazil, with subsequent evidence of a causal association. Sources of data: Systemic reviews, observational studies, public health organizations. Areas of agreement: Zika virus causes microcephaly and brain abnormalities in infants born to mothers infected during or shortly before pregnancy. Zika virus is a trigger for Guillain Barre Syndrome. Whilst mosquito bite is the main route of transmission, sexual transmission is another confirmed route. Areas of controversy: Uncertainty remains regarding the proportion of Zika-infected pregnancies that will give rise to a significantly affected infant. Growing points: The development of a vaccine remains a priority whilst public health efforts continue to educate at risk populations on reducing transmission. Areas timely for developing research: Follow-up studies of affected infants are vital to inform on prognosis and guide screening programmes of the future.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1711
[Cu] Fecha actualización por clase:171102
[Lr] Fecha última revisión:171102
[St] Status:Publisher
[do] DOI:10.1093/brimed/ldx038


  8 / 3468 MEDLINE  
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[PMID]:29094318
[Au] Autor:Pradhan D; Yadav M; Verma R; Khan NS; Jena L; Jain AK
[Ad] Dirección:Biomedical Informatics Centre, National Institute of Pathology-ICMR, New Delhi, 110029, India.
[Ti] Título:Discovery of T-cell Driven Subunit Vaccines from Zika Virus Genome: An Immunoinformatics Approach.
[So] Fuente:Interdiscip Sci;, 2017 Nov 01.
[Is] ISSN:1867-1462
[Cp] País de publicación:Germany
[La] Idioma:eng
[Ab] Resumen:The recent outbreaks of Zika virus and the absence of a specific therapy have necessitated to identify T-cell-stimulating antigenic peptides as potential subunit vaccine candidates. The translated ssRNA (+) genome of Zika virus was explored in EMBOSS antigenic and VaxiJen to predict 63 peptides as potential antigens. Three MHC-II binding peptide prediction tools, viz. NetMHCIIpan, PREDIVAC and immune epitope database (IEDB) were employed in consensus on 63 antigenic peptides to propose 14 T-helper cell epitopes. Similarly, analysis on 63 antigenic peptides through NetMHC, NetCTL and IEDB MHC-I binding peptide prediction tool led to identification of 14 CTL epitopes. Seven T-cell epitopes, C:44-66, M:135-149, NS2A:124-144, NS3:421-453, NS3:540-554, NS4B:90-134 and NS4B:171-188, are observed to share overlapping MHC-I and MHC-II binding motifs and hence, are being proposed to constitute minimum T-cell antigens to elicit protective T-cell immune response against Zika. Three of them, C:44-66, NS3:421-453 and NS3:540-554 are identified to be conserved across all the selected strains of Zika virus. Moreover, the 21 T-cell epitopes are non-self to humans and exhibited good coverage in variable populations of 14 geographical locations. Therefore, 21 T-cell epitopes are proposed as potential subunit vaccines against Zika virus.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1711
[Cu] Fecha actualización por clase:171102
[Lr] Fecha última revisión:171102
[St] Status:Publisher
[do] DOI:10.1007/s12539-017-0238-3


  9 / 3468 MEDLINE  
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[PMID]:29093521
[Au] Autor:Lin MY; Wang YL; Wu WL; Wolseley V; Tsai MT; Radic V; Thornton ME; Grubbs BH; Chow RH; Huang IC
[Ad] Dirección:Department of Physiology & Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
[Ti] Título:Zika Virus Infects Intermediate Progenitor Cells and Post-mitotic Committed Neurons in Human Fetal Brain Tissues.
[So] Fuente:Sci Rep;7(1):14883, 2017 Nov 01.
[Is] ISSN:2045-2322
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Zika virus (ZIKV) infection is associated with microcephaly in fetuses, but the pathogenesis of ZIKV-related microcephaly is not well understood. Here we show that ZIKV infects the subventricular zone in human fetal brain tissues and that the tissue tropism broadens with the progression of gestation. Our research demonstrates also that intermediate progenitor cells (IPCs) are the main target cells for ZIKV. Post-mitotic committed neurons become susceptible to ZIKV infection as well at later stages of gestation. Furthermore, activation of microglial cells, DNA fragmentation, and apoptosis of infected or uninfected cells could be found in ZIKV-infected brain tissues. Our studies identify IPCs as the main target cells for ZIKV. They also suggest that immune activation after ZIKV infection may play an important role in the pathogenesis of ZIKV-related microcephaly.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1711
[Cu] Fecha actualización por clase:171102
[Lr] Fecha última revisión:171102
[St] Status:In-Data-Review
[do] DOI:10.1038/s41598-017-13980-2


  10 / 3468 MEDLINE  
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[PMID]:29093135
[Au] Autor:Griffin I; Zhang G; Fernandez D; Cordero C; Logue T; White SL; Llau A; Thomas L; Moore E; Noya-Chaveco P; Etienne M; Rojas M; Goldberg C; Rodriguez G; Mejia-Echeverry A; Rico E; Gillis LD; Cone M; Jean R; Rivera L
[Ad] Dirección:Department of Epidemiology, Disease Control, and Immunization Services, Florida Department of Health in Miami-Dade County, Miami, Florida; and isabel.griffin@flhealth.gov.
[Ti] Título:Epidemiology of Pediatric Zika Virus Infections.
[So] Fuente:Pediatrics;, 2017 Nov 01.
[Is] ISSN:1098-4275
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:BACKGROUND AND OBJECTIVE: In July 2016, local transmission of Zika virus (ZIKV) was announced in Miami-Dade County, Florida. In this report, we describe the epidemiology of pediatric ZIKV infections in locally acquired and travel-associated cases. METHODS: All children aged 1 to 17 years tested for ZIKV between October 1, 2015, and March 29, 2017, were included. SAS 9.4 was used to analyze age, sex, race and/or ethnicity, origin of exposure, onset date, affiliation with a household cluster, clinical symptoms, hospitalizations, viremia, viruria, and antibody detection in specimens. RESULTS: Among 478 confirmed ZIKV cases in Miami-Dade County, 33 (6.9%) occurred in children (1-17 years). Twenty-seven (82.3%) cases were travel-associated. The median age of a pediatric Zika case patient was 11 years. Seventeen (51.5%) case patients were boys, and 23 (69.9%) were Hispanic. Among 31 symptomatic cases, all reported having rash, 25 (80.6%) reported fever, 9 (29.0%) reported conjunctivitis, and 7 (22.6%) reported arthralgia. Sixteen (48.5%) cases reported 2 of 4 and 8 (24.2%) reported 3 of 4 main symptoms. CONCLUSIONS: This report found that the majority of children identified during the 2016 ZIKV outbreak only presented with 2 of the 4 main symptoms. In addition, pediatric ZIKV cases were frequently associated with symptomatic household members.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1711
[Cu] Fecha actualización por clase:171102
[Lr] Fecha última revisión:171102
[St] Status:Publisher



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