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[PMID]:29500301
[Au] Autor:Alderwick H; Shortell SM; Briggs ADM; Fisher ES
[Ad] Dirección:Center for Health and Community, University of California, San Francisco, CA, USA Hugh.Alderwick@ucsf.edu.
[Ti] Título:Can accountable care organisations really improve the English NHS? Lessons from the United States.
[So] Fuente:BMJ;360:k921, 2018 03 02.
[Is] ISSN:1756-1833
[Cp] País de publicación:England
[La] Idioma:eng
[Mh] Términos MeSH primario: Organizaciones Responsables por la Atención
Política de Salud
Medicina Estatal/tendencias
[Mh] Términos MeSH secundario: Costos de la Atención en Salud
Seres Humanos
Calidad de la Atención de Salud
Reino Unido
Estados Unidos
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:180304
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.k921


  2 / 35951 MEDLINE  
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[PMID]:28456662
[Au] Autor:Kinkar L; Laurimäe T; Sharbatkhori M; Mirhendi H; Kia EB; Ponce-Gordo F; Andresiuk V; Simsek S; Lavikainen A; Irshadullah M; Umhang G; Oudni-M'rad M; Acosta-Jamett G; Rehbein S; Saarma U
[Ad] Dirección:Department of Zoology, Institute of Ecology and Earth Sciences, University of Tartu, Vanemuise 46, 50410 Tartu, Estonia.
[Ti] Título:New mitogenome and nuclear evidence on the phylogeny and taxonomy of the highly zoonotic tapeworm Echinococcus granulosus sensu stricto.
[So] Fuente:Infect Genet Evol;52:52-58, 2017 Aug.
[Is] ISSN:1567-7257
[Cp] País de publicación:Netherlands
[La] Idioma:eng
[Ab] Resumen:Cystic echinococcosis, a zoonotic disease caused by Echinococcus granulosus sensu lato (s. l.), is a significant global public health concern. Echinococcus granulosus s. l. is currently divided into numerous genotypes (G1-G8 and G10) of which G1-G3 are the most frequently implicated genotypes in human infections. Although it has been suggested that G1-G3 could be regarded as a distinct species E. granulosus sensu stricto (s. s.), the evidence to support this is inconclusive. Most importantly, data from nuclear DNA that provide means to investigate the exchange of genetic material between G1-G3 is lacking as none of the published nuclear DNA studies have explicitly included G2 or G3. Moreover, the commonly used relatively short mtDNA sequences, including the complete cox1 gene, have not allowed unequivocal differentiation of genotypes G1-G3. Therefore, significantly longer mtDNA sequences are required to distinguish these genotypes with confidence. The main aim of this study was to evaluate the phylogenetic relations and taxonomy of genotypes G1-G3 using sequences of nearly complete mitogenomes (11,443bp) and three nuclear loci (2984bp). A total of 23 G1-G3 samples were analysed, originating from 5 intermediate host species in 10 countries. The mtDNA data demonstrate that genotypes G1 and G3 are distinct mitochondrial genotypes (separated by 37 mutations), whereas G2 is not a separate genotype or even a monophyletic cluster, but belongs to G3. Nuclear data revealed no genetic separation of G1 and G3, suggesting that these genotypes form a single species due to ongoing gene flow. We conclude that: (a) in the taxonomic sense, genotypes G1 and G3 can be treated as a single species E. granulosus s. s.; (b) genotypes G1 and G3 should be regarded as distinct genotypes only in the context of mitochondrial data; (c) we recommend excluding G2 from the genotype list.
[Mh] Términos MeSH primario: Núcleo Celular/genética
ADN de Helmintos/genética
Echinococcus granulosus/clasificación
Mitocondrias/genética
[Mh] Términos MeSH secundario: África del Norte
Animales
Asia
Echinococcus granulosus/genética
Echinococcus granulosus/aislamiento & purificación
Echinococcus granulosus/metabolismo
Europa (Continente)
Genoma Mitocondrial
Genotipo
Seres Humanos
Filogenia
Filogeografía
América del Sur
Zoonosis/parasitología
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (DNA, Helminth)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170501
[St] Status:MEDLINE


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[PMID]:28449795
[Au] Autor:Packer M; McMurray JJV; Krum H; Kiowski W; Massie BM; Caspi A; Pratt CM; Petrie MC; DeMets D; Kobrin I; Roux S; Swedberg K; ENABLE Investigators and Committees
[Ad] Dirección:Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas. Electronic address: milton.packer1526@baylorhealth.edu.
[Ti] Título:Long-Term Effect of Endothelin Receptor Antagonism With Bosentan on the Morbidity and Mortality of Patients With Severe Chronic Heart Failure: Primary Results of the ENABLE Trials.
[So] Fuente:JACC Heart Fail;5(5):317-326, 2017 May.
[Is] ISSN:2213-1787
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:OBJECTIVES: The objective of this clinical trial was to evaluate the long-term effect of endothelin receptor antagonism with bosentan on the morbidity and mortality of patients with severe chronic heart failure. BACKGROUND: Endothelin may play a role in heart failure, but short-term clinical trials with endothelin receptor antagonists have reported disappointing results. Long-term trials are lacking. METHODS: In 2 identical double-blind trials, we randomly assigned 1,613 patients with New York Heart Association functional class IIIb to IV heart failure and an ejection fraction <35% to receive placebo or bosentan (target dose 125 mg twice daily) for a median of 1.5 years. The primary outcome for each trial was clinical status at 9 months (assessed by the hierarchical clinical composite); the primary outcome across the 2 trials was death from any cause or hospitalization for heart failure. RESULTS: Bosentan did not influence clinical status at 9 months in either trial (p = 0.928 and p = 0.263). In addition, 321 patients in the placebo group and 312 patients in the bosentan group died or were hospitalized for heart failure (hazard ratio [HR]: 1.01; 95% confidence interval [CI]: 0.86 to 1.18; p = 0.90). The bosentan group experienced fluid retention within the first 2 to 4 weeks, as evidenced by increased peripheral edema, weight gain, decreases in hemoglobin, and an increased risk of hospitalization for heart failure, despite intensification of background diuretics. During follow-up, 173 patients died in the placebo group and 160 patients died in the bosentan group (HR: 0.94; 95% CI: 0.75 to 1.16). About 10% of the bosentan group showed meaningful increases in hepatic transaminases, but none had acute or chronic liver failure. CONCLUSIONS: Bosentan did not improve the clinical course or natural history of patients with severe chronic heart failure and but caused early and important fluid retention.
[Mh] Términos MeSH primario: Causas de Muerte
Antagonistas de los Receptores de Endotelina/administración & dosificación
Insuficiencia Cardíaca/tratamiento farmacológico
Sulfonamidas/administración & dosificación
[Mh] Términos MeSH secundario: Anciano
Australia
Enfermedad Crónica
Relación Dosis-Respuesta a Droga
Método Doble Ciego
Esquema de Medicación
Antagonistas de los Receptores de Endotelina/efectos adversos
Europa (Continente)
Femenino
Insuficiencia Cardíaca/diagnóstico
Insuficiencia Cardíaca/mortalidad
Seres Humanos
Internacionalidad
Estimación de Kaplan-Meier
Masculino
Mediana Edad
Morbilidad
América del Norte
Pronóstico
Modelos de Riesgos Proporcionales
Ensayos Clínicos Controlados Aleatorios como Asunto
Medición de Riesgo
Índice de Severidad de la Enfermedad
Sulfonamidas/efectos adversos
Análisis de Supervivencia
Factores de Tiempo
Resultado del Tratamiento
[Pt] Tipo de publicación:JOURNAL ARTICLE; REVIEW
[Nm] Nombre de substancia:
0 (Endothelin Receptor Antagonists); 0 (Sulfonamides); Q326023R30 (bosentan)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180306
[Lr] Fecha última revisión:180306
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170429
[St] Status:MEDLINE


  4 / 35951 MEDLINE  
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[PMID]:29256285
[Au] Autor:Carnevali V; Nogueda-Torres B; Villagrán-Herrera ME; De Diego-Cabrera JA; Rocha-Chávez G; Martínez-Ibarra JA
[Ad] Dirección:1 Department of Public Health and Infectious Diseases, University of Rome , Rome , Italy.
[Ti] Título:Prevalence of Trypanosoma cruzi and organ alterations in Virginia opossums (Didelphis virginiana) from western Mexico - short communication.
[So] Fuente:Acta Vet Hung;65(4):505-509, 2017 12.
[Is] ISSN:0236-6290
[Cp] País de publicación:Hungary
[La] Idioma:eng
[Ab] Resumen:Small populations of Virginia opossum (Didelphis virginiana) in western Mexico are endangered by hunting and natural predators as well as by different kinds of diseases. After two serological analyses using Serodia® latex particle agglutination and indirect haemagglutination (IHA) tests, 35 (53.03%) of 66 collected opossums in two small towns in western Mexico were positive for the presence of Trypanosoma cruzi. Twenty-eight of the 35 seropositive opossums had pathological lesions: 11 had changes in only one organ, 13 in two organs, and four had pathological changes in three organs. Splenomegaly was the most common finding in the examined opossums, followed by hepatomegaly. These potentially fatal pathological changes could contribute to the scarcity of the opossum population, even leading to the extinction of this species in western Mexico.
[Mh] Términos MeSH primario: Didelphis/parasitología
Trypanosoma cruzi/aislamiento & purificación
Tripanosomiasis/veterinaria
[Mh] Términos MeSH secundario: Animales
Cardiomegalia/epidemiología
Cardiomegalia/parasitología
Cardiomegalia/veterinaria
Acalasia del Esófago/epidemiología
Acalasia del Esófago/parasitología
Acalasia del Esófago/veterinaria
Hepatomegalia/epidemiología
Hepatomegalia/parasitología
Hepatomegalia/veterinaria
México/epidemiología
Esplenomegalia/epidemiología
Esplenomegalia/parasitología
Esplenomegalia/veterinaria
Tripanosomiasis/epidemiología
Tripanosomiasis/patología
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180305
[Lr] Fecha última revisión:180305
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:171220
[St] Status:MEDLINE
[do] DOI:10.1556/004.2017.048


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[PMID]:29356817
[Au] Autor:Stevenson R; Moore DE
[Ad] Dirección:Editor in Chief, , Glasgow, United Kingdom.
[Ti] Título:Ascent to the Summit of the CME Pyramid.
[So] Fuente:JAMA;319(6):543-544, 2018 Feb 13.
[Is] ISSN:1538-3598
[Cp] País de publicación:United States
[La] Idioma:eng
[Mh] Términos MeSH primario: Educación Médica Continua
[Mh] Términos MeSH secundario: Competencia Clínica
Educación Médica Continua/métodos
Educación Médica Continua/normas
Europa (Continente)
Accesibilidad a los Servicios de Salud
América del Norte
Calidad de la Atención de Salud
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180301
[Lr] Fecha última revisión:180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:180123
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.19791


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[PMID]:29361656
[Au] Autor:Mortenson LC; Thomson Reuters Accelus.
[Ti] Título:Medicaid Waivers.
[So] Fuente:Issue Brief Health Policy Track Serv;2017:1-39, 2017 Dec 26.
[Cp] País de publicación:United States
[La] Idioma:eng
[Mh] Términos MeSH primario: Medicaid/organización & administración
[Mh] Términos MeSH secundario: Servicios de Salud Comunitaria
Servicios de Salud Dental
Determinación de la Elegibilidad
Empleo
Reforma de la Atención de Salud
Servicios de Atención de Salud a Domicilio
Seres Humanos
Indios Norteamericanos
Cobertura del Seguro
Pacientes no Asegurados
Servicios de Salud Mental
Patient Protection and Affordable Care Act
Gobierno Estatal
Detección de Abuso de Sustancias
Estados Unidos
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180219
[Lr] Fecha última revisión:180219
[Sb] Subgrupo de revista:T
[Da] Fecha de ingreso para procesamiento:180124
[St] Status:MEDLINE


  7 / 35951 MEDLINE  
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[PMID]:28745404
[Au] Autor:Kadlec SM; Johnson RD; Mount DR; Olker JH; Borkholder BD; Schoff PK
[Ad] Dirección:Integrated Biosciences Graduate Program, University of Minnesota-Duluth, Minnesota, USA.
[Ti] Título:Testicular oocytes in smallmouth bass in northeastern Minnesota in relation to varying levels of human activity.
[So] Fuente:Environ Toxicol Chem;36(12):3424-3435, 2017 Dec.
[Is] ISSN:1552-8618
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Testicular oocytes (TOs) have been found in black bass (Micropterus spp.) from many locations in North America. The presence of TOs is often assumed to imply exposure to estrogenic endocrine disrupting compounds (EDCs); however, a definitive causal relationship has yet to be established, and TO prevalence is not consistently low in fish from areas lacking evident EDC sources. This might indicate any of a number of situations: 1) unknown or unidentified EDCs or EDC sources, 2) induction of TOs by other stressors, or 3) testicular oocytes occurring spontaneously during normal development. In the present study, we analyzed TO occurrence in smallmouth bass (Micropterus dolomieu) from 8 populations in northeastern Minnesota watersheds with differing degrees of human development and, hence, presumed likelihood of exposure to anthropogenic chemicals. Three watersheds were categorized as moderately developed, based on the presence of municipal wastewater discharges and higher human population density (4-81 per km ), and 5 watersheds were minimally developed, with very low human population density (0-1 per km ) and minimal built environment. Testicular tissues from mature fish were evaluated using a semiquantitative method that estimated TO density, normalized by cross-sectional area. Testicular oocyte prevalence and density among populations from moderately developed watersheds was higher than in populations from minimally developed watersheds. However, TO prevalence was unexpectedly high and variable (7-43%) in some populations from minimally developed watersheds, and only weak evidence was found for a relationship between TO density and watershed development, suggesting alternative or more complex explanations for TO presence in smallmouth bass from this region. Environ Toxicol Chem 2017;36:3424-3435. © 2017 SETAC.
[Mh] Términos MeSH primario: Disruptores Endocrinos/toxicidad
Oocitos/efectos de los fármacos
Testículo/efectos de los fármacos
Aguas Residuales/toxicidad
Contaminantes Químicos del Agua/toxicidad
[Mh] Términos MeSH secundario: Animales
Lubina
Actividades Humanas
Seres Humanos
Masculino
Minnesota
América del Norte
Oocitos/patología
Densidad de Población
Ríos/química
Testículo/patología
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Endocrine Disruptors); 0 (Waste Water); 0 (Water Pollutants, Chemical)
[Em] Mes de ingreso:1712
[Cu] Fecha actualización por clase:180218
[Lr] Fecha última revisión:180218
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170727
[St] Status:MEDLINE
[do] DOI:10.1002/etc.3928


  8 / 35951 MEDLINE  
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[PMID]:29320572
[Au] Autor:McCloskey SE; Uher-Koch BD; Schmutz JA; Fondell TF
[Ad] Dirección:U.S. Geological Survey, Alaska Science Center, Anchorage, Alaska, United States of America.
[Ti] Título:International migration patterns of Red-throated Loons (Gavia stellata) from four breeding populations in Alaska.
[So] Fuente:PLoS One;13(1):e0189954, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Identifying post-breeding migration and wintering distributions of migratory birds is important for understanding factors that may drive population dynamics. Red-throated Loons (Gavia stellata) are widely distributed across Alaska and currently have varying population trends, including some populations with recent periods of decline. To investigate population differentiation and the location of migration pathways and wintering areas, which may inform population trend patterns, we used satellite transmitters (n = 32) to describe migration patterns of four geographically separate breeding populations of Red-throated Loons in Alaska. On average (± SD) Red-throated Loons underwent long (6,288 ± 1,825 km) fall and spring migrations predominantly along coastlines. The most northern population (Arctic Coastal Plain) migrated westward to East Asia and traveled approximately 2,000 km farther to wintering sites than the three more southerly populations (Seward Peninsula, Yukon-Kuskokwim Delta, and Copper River Delta) which migrated south along the Pacific coast of North America. These migration paths are consistent with the hypothesis that Red-throated Loons from the Arctic Coastal Plain are exposed to contaminants in East Asia. The three more southerly breeding populations demonstrated a chain migration pattern in which the more northerly breeding populations generally wintered in more northerly latitudes. Collectively, the migration paths observed in this study demonstrate that some geographically distinct breeding populations overlap in wintering distribution while others use highly different wintering areas. Red-throated Loon population trends in Alaska may therefore be driven by a wide range of effects throughout the annual cycle.
[Mh] Términos MeSH primario: Migración Animal
Aves/fisiología
[Mh] Términos MeSH secundario: Alaska
Animales
América del Norte
Dinámica Poblacional
Estaciones del Año
Telemetría
[Pt] Tipo de publicación:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180214
[Lr] Fecha última revisión:180214
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189954


  9 / 35951 MEDLINE  
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[PMID]:27776586
[Au] Autor:Cruz AT; Hersh AL; Starke JR; Beekmann SE; Polgreen PM; Banerjee R
[Ad] Dirección:Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
[Ti] Título:Controversies in tuberculous infection among pediatric infectious disease specialists in North America.
[So] Fuente:Int J Tuberc Lung Dis;20(11):1463-1468, 2016 Nov.
[Is] ISSN:1815-7920
[Cp] País de publicación:France
[La] Idioma:eng
[Ab] Resumen:OBJECTIVE: To evaluate the extent to which advancements in the diagnosis and treatment of latent tuberculous infection (LTBI) have been integrated into practice by pediatric infectious disease (PID) specialists. DESIGN: We conducted an online survey of the Infectious Diseases Society of America's Emerging Infections Network (EIN) membership. RESULTS: Of the 323 members, 197 (61%) responded: 7% cared for ⩾5 children with TB disease and 34% for ⩾5 children with LTBI annually. We identified substantial variations in the use of interferon-gamma release assays (IGRAs) based upon age, immune status, and TB risk factors. In addition, tuberculin skin test (TST) use was three times more common in younger children. Variations existed in managing children with discordant TST and IGRA results. Less variation existed in LTBI treatment, with 86% preferring a 9-month course of isoniazid; few other, newer regimens were used routinely. CONCLUSION: Substantial variations exist in LTBI management; uptake of newer diagnostic tools and treatment regimens has been slow. Variations in practice and the lag time to integrating new data into practice may indicate the relative infrequency with which providers encounter LTBI. Our findings reflect the need for increased visibility of existing TB guidelines and resources for expert consultation for scenarios not covered by guidelines.
[Mh] Términos MeSH primario: Enfermedades Transmisibles/diagnóstico
Enfermedades Transmisibles/epidemiología
Tuberculosis Latente/diagnóstico
Tuberculosis Latente/epidemiología
Pediatría
[Mh] Términos MeSH secundario: Niño
Manejo de la Enfermedad
Seres Humanos
Ensayos de Liberación de Interferón gamma
Internet
América del Norte/epidemiología
Guías de Práctica Clínica como Asunto
Factores de Riesgo
Encuestas y Cuestionarios
Prueba de Tuberculina
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180214
[Lr] Fecha última revisión:180214
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:161026
[St] Status:MEDLINE


  10 / 35951 MEDLINE  
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[PMID]:28743642
[Au] Autor:Zuo YJ; Wen J; Zhou SL
[Ad] Dirección:State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China; Shanghai Chenshan Plant Science Research Center, Chinese Academy of Sciences; Shanghai Chenshan Botanical Garden, Shanghai 201602, China.
[Ti] Título:Intercontinental and intracontinental biogeography of the eastern Asian - Eastern North American disjunct Panax (the ginseng genus, Araliaceae), emphasizing its diversification processes in eastern Asia.
[So] Fuente:Mol Phylogenet Evol;117:60-74, 2017 Dec.
[Is] ISSN:1095-9513
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:The intercontinental biogeography between eastern Asia and eastern North America has attracted much attention from evolutionary biologists. Further insights into understanding the evolution of the intercontinental disjunctions have been hampered by the lack of studies on the intracontinental biogeography in eastern Asia, a region with complex geology, geography, climates and habitats. Herein we studied the biogeographic history of the eastern Asian-eastern North American disjunct genus Panax with special emphasis on the investigation of its uneven diversification in Asia. This study reconstructs the diversification history of Panax and also emphasizes a large clade of Panax taxa, which has a wide distribution in eastern Asia, but was unresolved in previous studies. We examined the noncoding plastid DNA fragments of trnH-psbA, rps16, and psbM-trnD, the mitochondrial b/c intron of NAD1, and the nuclear ribosomal internal transcribed spacer (ITS) region of 356 samples from 47 populations. The results revealed the subtropical Northern Hemisphere origin (Asia or Asia and North America) of Panax in the Paleocene. Intercontinental disjunctions between eastern Asia and eastern North America formed twice in Panax, once estimated in early Eocene for the split of P. trifolius and another in mid-Miocene for the divergence of P. quinquefolius. Intercontinental diversifications in Panax showed temporal correlation with the increase of global temperature. The evolutionary radiation of the P. bipinnatifidus species complex occurred around the boundary of Oligocene and Miocene. Strong genetic structure among populations of the species complex was detected and the populations may be isolated by distance. The backbone network and the Bayesian clustering analysis revealed a major evolutionary radiation centered in the Hengduan Mountains of western China. Our results suggested that the evolutionary radiation of Panax was promoted by geographic barriers, including mountain ranges (Hengduan Mountains, Nanling Mountains and Wuyishan Mountains), oceans and altitudinal shifts, which further contribute to the knowledge of the uneven species diversification between eastern Asia and North America.
[Mh] Términos MeSH primario: Panax/genética
Filogenia
Filogeografía
[Mh] Términos MeSH secundario: Teorema de Bayes
Biodiversidad
Lejano Oriente
Genes Mitocondriales/genética
América del Norte
Panax/clasificación
Plastidios/genética
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180213
[Lr] Fecha última revisión:180213
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170727
[St] Status:MEDLINE



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