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[PMID]: 21509716 [Au] Autor: Dong WH; Mei WL; Zhao YX; Zeng YB; Zuo WJ; Wang H; Li XN; Dai HF [Ad] Dirección: Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, P. R. China. [Ti] Título: Cytotoxic cardenolide glycosides from the seeds of Antiaris toxicaria. [So] Fuente: Planta Med;77(15):1730-4, 2011 Oct. [Is] ISSN: 1439-0221 [Cp] País de publicación: Germany [La] Idioma: eng [Ab] Resumen: Bioassay-guided fractionation of the ethanolic extract from the seeds of Antiaris toxicaria led to the isolation of three new cardiac glycosides named toxicarioside J, toxicarioside K, and toxicarioside L, together with a known glucostrophalloside. The structures of the new compounds were elucidated by spectroscopic methods including HRESIMS, UV, IR, and 1D, 2D NMR techniques. The cytotoxic activities of these cardiac glycosides against human gastric (SGC-7901) and human hepatoma (SMMC-7721) cell lines were evaluated, and all of them exhibited significant cytotoxicity. [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mes de ingreso: 1110 [Sb] Subgrupo de revista: IM [St] Status: In-Process [do] DOI: 10.1055/s-0030-1271045

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[PMID]: 22348979 [Au] Autor: Levrier C; Kiremire B; Guéritte F; Litaudon M [Ad] Dirección: Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, LabEx LERMIT, 1 Avenue de la Terrasse, 91198 Gif-Sur-Yvette cedex, France. [Ti] Título: Toxicarioside M, a new cytotoxic 10ß-hydroxy-19-nor-cardenolide from Antiaris toxicaria. [So] Fuente: Fitoterapia;83(4):660-4, 2012 Jun. [Is] ISSN: 1873-6971 [Cp] País de publicación: Netherlands [La] Idioma: eng [Ab] Resumen: A new 10ß-hydroxy-19-nor-cardenolide, named toxicarioside M (1), was isolated from the trunk bark of Antiaris toxicaria (Pers.) Lesch (Moraceae), along with six known cardenolides (convallatoxin (2), convallatoxol (3), convalloside (4), 3-O-ß-D-xylopyranosylstrophanthidin (5), glucostrophanthidin (6) and strophanthidin (7)). Their structures were elucidated on the basis of HR-MS(n) analysis, spectroscopic methods (IR, UV, 1D and 2D NMR) and by comparison with data reported in the literature. The cardenolides were evaluated for their cytotoxic activity against KB, HCT-116, SF-268, MCF-7, HL-60, PC-3 and MRC-5 cell lines. [Mh] Términos MeSH primario: Antiaris/química Antineoplásicos Fitogénicos/uso terapéutico Cardenólidos/uso terapéutico Neoplasias/quimioterapia Fitoterapia [Mh] Términos MeSH secundario: Antineoplásicos Fitogénicos/aislamiento & purificación Antineoplásicos Fitogénicos/farmacología Cardenólidos/aislamiento & purificación Cardenólidos/farmacología Línea Celular Tumoral Humanos Estructura Molecular Corteza de la Planta Extractos Vegetales/química Extractos Vegetales/farmacología Extractos Vegetales/uso terapéutico Tallos de la Planta [Pt] Tipo de publicación: JOURNAL ARTICLE [Nm] Nombre de substancia: 0 (10beta-hydroxy-19-nor-cardenolide); 0 (Antineoplastic Agents, Phytogenic); 0 (Cardenolides); 0 (Plant Extracts) [Em] Mes de ingreso: 1209 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 120604 [St] Status: MEDLINE [do] DOI: 10.1016/j.fitote.2012.02.001

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[PMID]: 22221748 [Au] Autor: Li YN; Huang FY; Mei WL; Dai HF; Guo JL; Tan GH; Zhou P [Ad] Dirección: Agriculture College, and Hainan Provincial Key Laboratory of Tropical Medicine, Hainan University, Haikou, China [Ti] Título: Toxicarioside A, isolated from tropical Antiaris toxicaria, blocks endoglin/TGF-ß signaling in a bone marrow stromal cell line. [So] Fuente: Asian Pac J Trop Med;5(2):91-7, 2012 Feb. [Is] ISSN: 1995-7645 [Cp] País de publicación: Singapore [La] Idioma: eng [Ab] Resumen: OBJECTIVE: To investigate possible mechanism of toxicarioside A in HS-5 bone stromal cells. METHODS: HS-5 bone stromal cells were cultured in media supplemented with various concentrations of toxicarioside A or control DMSO (not treatment). Endoglin and TGF-ß were detected by Northern and Western blot analysis and quantified in a standard method. Downstream molecules of endoglin and TGF-ß (Smad1, Smad2 and their active phosphorylated counterparts, pSmad1 and pSmad2) were also detected and quantified by Western blot analysis. In addition, cell proliferation assay and small interfering RNA (siRNA) against endoglin were used to certificate the function of endolgin in the HS-5 cells. RESULTS: Compared with the not treated (0 µg/mL) or DMSO treated control HS-5 cells, HS-5 cells treated with toxicarioside A were found significant attenuation of endolgin and TGF-ß expression. Significant inhibition of cell proliferation was also found in the HS-5 cells treated with toxicarioside A. ALK1-related Smad1 and ALK5-related Smad2 were decreased in HS-5 cells treated with toxicarioside A. In addition, phosphorylated Smad1 (pSmad1) and Smad2 (pSmad2) were also found attenuation in toxicarioside A-treated HS-5 cells. RNA interference showed that blockage of endoglin by siRNA also decreased Smad1 and Smad2 expression in HS-5 cells. CONCLUSIONS: Our results indicate that toxicarioside A can influence bone marrow stromal HS-5's function and inhibit HS-5 cell proliferation by alteration of endoglin-related ALK1 (Smad1) and ALK5 (Smad2) signaling. [Mh] Términos MeSH primario: Antiaris Células de la Médula Ósea/efectos de drogas Cardenólidos/farmacología Receptores de Superficie Celular/antagonistas & inhibidores Proteína Smad1/metabolismo Proteína Smad2/metabolismo Factor de Crecimiento Transformador beta/antagonistas & inhibidores [Mh] Términos MeSH secundario: Antígenos CD/metabolismo Northern Blotting Western Blotting Células de la Médula Ósea/metabolismo Línea Celular Proliferación de la Célula Humanos Masculino Receptores de Superficie Celular/metabolismo Transducción de Señal/efectos de drogas Proteína Smad1/efectos de drogas Proteína Smad2/efectos de drogas Células del Estroma/efectos de drogas Factor de Crecimiento Transformador beta/metabolismo [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (Antigens, CD); 0 (Cardenolides); 0 (ENG protein, human); 0 (Receptors, Cell Surface); 0 (Smad1 Protein); 0 (Smad2 Protein); 0 (Transforming Growth Factor beta) [Em] Mes de ingreso: 1203 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 120106 [St] Status: MEDLINE [do] DOI: 10.1016/S1995-7645(12)60002-9

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[PMID]: 21674063 [Au] Autor: Bai X; Yang L; Tian M; Chen J; Shi J; Yang Y; Hu X [Ad] Dirección: Key Laboratory of Biodiversity and Biogeography, Institute of Tibet Plateau Research at Kunming, Chinese Academy of Science, Kunming, China. [Ti] Título: Nitric oxide enhances desiccation tolerance of recalcitrant Antiaris toxicaria seeds via protein S-nitrosylation and carbonylation. [So] Fuente: PLoS One;6(6):e20714, 2011. [Is] ISSN: 1932-6203 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: The viability of recalcitrant seeds is lost following stress from either drying or freezing. Reactive oxygen species (ROS) resulting from uncontrolled metabolic activity are likely responsible for seed sensitivity to drying. Nitric oxide (NO) and the ascorbate-glutathione cycle can be used for the detoxification of ROS, but their roles in the seed response to desiccation remain poorly understood. Here, we report that desiccation induces rapid accumulation of H(2)O(2), which blocks recalcitrant Antiaris toxicaria seed germination; however, pretreatment with NO increases the activity of antioxidant ascorbate-glutathione pathway enzymes and metabolites, diminishes H(2)O(2) production and assuages the inhibitory effects of desiccation on seed germination. Desiccation increases the protein carbonylation levels and reduces protein S-nitrosylation of these antioxidant enzymes; these effects can be reversed with NO treatment. Antioxidant protein S-nitrosylation levels can be further increased by the application of S-nitrosoglutathione reductase inhibitors, which further enhances NO-induced seed germination rates after desiccation and reduces desiccation-induced H(2)O(2) accumulation. These findings suggest that NO reinforces recalcitrant seed desiccation tolerance by regulating antioxidant enzyme activities to stabilize H(2)O(2) accumulation at an appropriate concentration. During this process, protein carbonylation and S-nitrosylation patterns are used as a specific molecular switch to control antioxidant enzyme activities. [Mh] Términos MeSH primario: Antiaris/metabolismo Desecación Óxido Nítrico/farmacología Proteínas de Plantas/metabolismo Carbonilación Proteica/efectos de drogas Semillas/metabolismo Azufre/metabolismo [Mh] Términos MeSH secundario: Antiaris/efectos de drogas Antiaris/enzimología Antiaris/fisiología Antioxidantes/metabolismo Germinación/efectos de drogas Peróxido de Hidrógeno/metabolismo Óxido Nítrico/metabolismo Proteínas de Plantas/química Semillas/efectos de drogas Semillas/enzimología Semillas/fisiología Estrés Fisiológico/efectos de drogas [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (Antioxidants); 0 (Plant Proteins); 10102-43-9 (Nitric Oxide); 7704-34-9 (Sulfur); 7722-84-1 (Hydrogen Peroxide) [Em] Mes de ingreso: 1109 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 110615 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0020714

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[PMID]: 21623521 [Au] Autor: Dong WH; Mei WL; Zhao YX; Zeng YB; Wang H; Dai HF [Ad] Dirección: Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China. [Ti] Título: A new drimane sesquiterpenoid glycoside from the seeds of Antiaris toxicaria. [So] Fuente: J Asian Nat Prod Res;13(6):561-5, 2011 Jun. [Is] ISSN: 1477-2213 [Cp] País de publicación: England [La] Idioma: eng [Ab] Resumen: A new drimane sesquiterpenoid glycoside, named 7-drimen-3ß,11-diol 3-O-ß-d-glucopyranoside, was isolated from the 95% EtOH extract of the seeds of Antiaris toxicaria (Pers.) Lesch. The chemical structure was completely elucidated using a combination of 1D and 2D NMR techniques (COSY, HMQC, HMBC, and ROESY) and HR-ESI-MS analysis. The compound showed inhibitory activities toward methicillin-resistant Staphylococcus aureus (MRSA), chronic myelogenous leukemia (K562), and human hepatoma (SMMC-7721) cell lines. [Mh] Términos MeSH primario: Antiaris/química Antineoplásicos Fitogénicos/aislamiento & purificación Medicamentos Herbarios Chinos/aislamiento & purificación Glucósidos/aislamiento & purificación Sesquiterpenos/aislamiento & purificación [Mh] Términos MeSH secundario: Antiinfecciosos Antineoplásicos Fitogénicos/química Antineoplásicos Fitogénicos/farmacología Ensayos de Selección de Medicamentos Antitumorales Medicamentos Herbarios Chinos/química Medicamentos Herbarios Chinos/farmacología Glucósidos/química Glucósidos/farmacología Humanos Células K562 Staphylococcus aureus Resistente a Meticilina/efectos de drogas Resonancia Magnética Nuclear Biomolecular Semillas/química Sesquiterpenos/química Sesquiterpenos/farmacología [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (7-drimen-3beta,11-diol 3-O-beta-D-glucopyranoside); 0 (Anti-Infective Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Drugs, Chinese Herbal); 0 (Glucosides); 0 (Sesquiterpenes); 0 (drimane) [Em] Mes de ingreso: 1109 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 110530 [St] Status: MEDLINE [do] DOI: 10.1080/10286020.2011.573479

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[PMID]: 20533166 [Au] Autor: Vouffo B; Dongo E; Facey P; Thorn A; Sheldrick G; Maier A; Fiebig HH; Laatsch H [Ad] Dirección: Department of Organic and Biomolecular Chemistry, University of Göttingen, Göttingen, Germany. [Ti] Título: Antiarol cinnamate and africanoside, a cinnamoyl triterpene and a hydroperoxy-cardenolide from the stem bark of Antiaris africana. [So] Fuente: Planta Med;76(15):1717-23, 2010 Oct. [Is] ISSN: 1439-0221 [Cp] País de publicación: Germany [La] Idioma: eng [Ab] Resumen: From the methanol extract of the stem bark of the African tree Antiaris africana Engler, two new bioactive metabolites were isolated, namely, the α-amyrin derivative 1ß,11α-dihydroxy-3ß-cinnamoyl-α-amyrin (antiarol cinnamate, 1) and a cardiac glycoside, 3ß-O-(α-L-rhamnopyranosyl)-14ß-hydroperoxy-5ß-hydroxy-19-oxo-17ß-card-20(22)-enolide (africanoside, 2a), together with the known compounds ß-amyrin and its acetate, ß-sitosterol and its 3-O-ß-D-glucopyranoside, friedelin, ursolic and oleanolic acid, 19-norperiplogenin, strophanthidol, strophanthidinic acid, periplogenin (3a), 3-epiperiplogenin, strophanthidin (3b) and 3,3'-dimethoxy-4'-O-ß-D-xylopyronosyl-ellagic acid. Their structures were established on the basis of their spectroscopic data and by chemical methods, while 3a was additionally confirmed by X-ray crystal structure analysis. The aglycone moiety possessing a hydroperoxy group was found for the first time in cardenolides. Compounds 1 and 2a showed no activity against bacteria, fungi, and microalgae; however, the crude extract exhibited a high toxicity against Artemia salina and a selective antitumor activity against human tumor cell lines. Africanoside (2a) effected a concentration-dependent inhibition of tumor cell growth with a mean IC(50) value of 5.3 nM. [Mh] Términos MeSH primario: Antiaris/química Glicósidos Cardíacos/farmacología Cinamatos/farmacología Citostáticos/farmacología Triterpenos/farmacología [Mh] Términos MeSH secundario: Animales Artemia/efectos de drogas Glicósidos Cardíacos/química Glicósidos Cardíacos/aislamiento & purificación Línea Celular Tumoral Cinamatos/química Cinamatos/aislamiento & purificación Cristalografía por Rayos X Citostáticos/química Citostáticos/aislamiento & purificación Humanos Pruebas de Sensibilidad Microbiana Resonancia Magnética Nuclear Biomolecular Corteza de la Planta/química Extractos Vegetales/química Extractos Vegetales/aislamiento & purificación Extractos Vegetales/farmacología Tallos de la Planta/química Triterpenos/química Triterpenos/aislamiento & purificación [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (11alpha-dihydroxy-3beta-cinnamoyl-alpha-amyrin); 0 (3beta-O-(alpha-L-rhamnopyranosyl)-14beta-hydroperoxy-5beta-hydroxy-19-oxo-17beta-card-20(22)-enolide); 0 (Cardiac Glycosides); 0 (Cinnamates); 0 (Cytostatic Agents); 0 (Plant Extracts); 0 (Triterpenes) [Em] Mes de ingreso: 1104 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 101025 [St] Status: MEDLINE [do] DOI: 10.1055/s-0030-1249958

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[PMID]: 20737830 [Au] Autor: Moshi MJ; Innocent E; Magadula JJ; Otieno DF; Weisheit A; Mbabazi PK; Nondo RS [Ad] Dirección: Department of Biological and Preclinical Studies, Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, Box 65001, Dar es Salaam, Tanzania. mmoshi@muhas.ac.tz [Ti] Título: Brine shrimp toxicity of some plants used as traditional medicines in Kagera Region, north western Tanzania. [So] Fuente: Tanzan J Health Res;12(1):63-7, 2010 Jan. [Is] ISSN: 1821-6404 [Cp] País de publicación: Tanzania [La] Idioma: eng [Ab] Resumen: Dichloromethane and/or ethanol extracts of 30 plants used as traditional medicines in Bukoba district, northwestern Tanzania were evaluated for brine shrimp toxicity. Among the 50 extracts tested, 32 extracts (64%) showed very low toxicity with LC50 values above 100 microg/ml. Among these 12 (24%) which had LC50 >500 microg/ml can be categorized as being practically non-toxic. Among the remaining extracts 19 (38%) which showed LC50 > 100 < 500 microg/ml are also considered to be non-toxic. Extracts that showed LC50 results between 30-100 microg/ml have been categorized as mildly toxic; these include ethanol extracts of Lantana trifolia (LC50 32.3 microg/ml), Vernonia bradycalyx (LC50 33.9 microg/ml), Antiaris toxicaria (LC50 38.2 microg/ml) and Rubus rigidus (LC50 41.7 microg/ml) and the dichloromethane extracts of Gynura scandens (LC50 36.5 microg/ml) and Bridelia micrantha (LC50 32.0 microg/ml). The dichloromethane extracts of Picralima nitida (LC50 18.3 microg/ml) and Rubus rigidus (LC50 19.8 microg/ml), were only moderately toxic. Picralima nitida and Rubus rigidus extracts are only 1.1 and 1.2 less toxic than the standard drug, cyclophosphamide (LC50 16.3 microg/ml). In conclusion, the results indicate that among the 30 plants used as traditional medicines, 28 are safe for short term use. Picralima nitida and Rubus rigidus extracts are mildly toxic, but by comparison have a remote possibility to yield active anticancer compounds. [Mh] Términos MeSH primario: Artemia/efectos de drogas Dosificación Letal Mediana Extractos Vegetales/toxicidad Plantas Medicinales/toxicidad [Mh] Términos MeSH secundario: Animales Humanos Medicina Tradicional Africana Extractos Vegetales/análisis Hojas de la Planta Raíces de la Planta Tallos de la Planta Plantas Medicinales/química Almácigo Tanzanía [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (Plant Extracts) [Em] Mes de ingreso: 1009 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 100826 [St] Status: MEDLINE

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[PMID]: 20553004 [Au] Autor: Shi LS; Liao YR; Su MJ; Lee AS; Kuo PC; Damu AG; Kuo SC; Sun HD; Lee KH; Wu TS [Ad] Dirección: Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, Republic of China. [Ti] Título: Cardiac glycosides from Antiaris toxicaria with potent cardiotonic activity. [So] Fuente: J Nat Prod;73(7):1214-22, 2010 Jul 23. [Is] ISSN: 1520-6025 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: An ethanolic extract of Antiaris toxicaria trunk bark showed potent in vitro cardiotonic effect on isolated guinea pig atria. Bioassay-guided fractionation of the extract led to identification of nine new cardiac glycosides (1-9, named antiarosides A-I), antiarotoxinin A (10), and 18 known compounds. Their structures were established using MS and NMR spectroscopic studies, including homonuclear and heteronuclear correlation experiments. The ability of these cardiotonic compounds to produce positive inotropic action and their safety indexes were examined in comparison with those of ouabain, a classical inhibitor of Na(+)/K(+)-ATPase. Malayoside (23) was nearly equipotent and had a similar safety index to ouabain in guinea pig atria. However, the maximal positive inotropic effect and safety index of 23 in papillary muscle were better than those of ouabain. An electrophysiological recording showed that 23 inhibited the sodium pump current in a concentration-dependent manner. [Mh] Términos MeSH primario: Antiaris/química Glicósidos Cardíacos/aislamiento & purificación Glicósidos Cardíacos/farmacología Cardiotónicos/aislamiento & purificación Cardiotónicos/farmacología Medicamentos Herbarios Chinos/aislamiento & purificación Medicamentos Herbarios Chinos/farmacología [Mh] Términos MeSH secundario: Animales Glicósidos Cardíacos/química Cardiotónicos/química Relación Dosis-Respuesta a Droga Medicamentos Herbarios Chinos/química Cobayas Atrios Cardíacos/efectos de drogas Ouabaína/farmacología Corteza de la Planta/química Tallos de la Planta/química Sodio/metabolismo ATPasa Intercambiadora de Sodio-Potasio/antagonistas & inhibidores [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (Cardiac Glycosides); 0 (Cardiotonic Agents); 0 (Drugs, Chinese Herbal); 630-60-4 (Ouabain); 7440-23-5 (Sodium); EC 3.6.3.9 (Sodium-Potassium-Exchanging ATPase) [Em] Mes de ingreso: 1008 [Cu] Fecha actualización por clase: 110801 [Lr] Fecha última revisión: 110801 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 100806 [St] Status: MEDLINE [do] DOI: 10.1021/np9005212

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[PMID]: 20537039 [Au] Autor: Xin X; Jing XM; Liu Y; Song SQ [Ad] Dirección: Institute of Botany, the Chinese Academy of Sciences, Beijing 100093, China. [Ti] Título: Viability loss pattern under rapid dehydration of Antiaris toxicaria axes and its relation to oxidative damage. [So] Fuente: J Integr Plant Biol;52(5):434-41, 2010 May. [Is] ISSN: 1744-7909 [Cp] País de publicación: China (Republic : 1949- ) [La] Idioma: eng [Ab] Resumen: The relation between oxidative damage and viability loss of excised embryonic axes of Antiaris toxicaria subjected to rapid drying with silica gel at 15 degrees C was studied. Changes of survival rate, accumulation of thiobarbituric acid-reactive substances (TBARs), activities of superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), glutathione reductase (GR) and the permeability of cell membrane that was determined as relative electrolyte leakage (REL) were measured. The half-life moisture content (MC(L50)) was 0.41 g H2O/g DW (dry weight basis). During drying, the activities of SOD, CAT and APX increased until MC(L50), and declined thereafter. The generation speed of (.)O2(-), and content of H2O2 and TBARs remained steadily or even decreased at MC levels higher than MC(L50), demonstrating a low oxidative level in these axes. There was no significant correlation between viability loss and accumulation of reactive oxygen species or lipid peroxidation within the dehydration process until MC(L50). Whereas the increase in REL from the beginning of the drying process indicated that the cell membrane was damaged. In conclusion, under rapid drying with silica gel the viability loss of excised recalcitrant A. toxicaria axes seemed to be triggered by mechanical or physical damage, rather than metabolic damage. [Mh] Términos MeSH primario: Antiaris/embriología Antiaris/fisiología Estrés Oxidativo Semillas/fisiología Supervivencia Tisular/fisiología [Mh] Términos MeSH secundario: Antiaris/enzimología Membrana Celular/metabolismo Deshidratación Electrólitos/metabolismo Depuradores de Radicales Libres/metabolismo Peróxido de Hidrógeno/metabolismo Peroxidación de Lípido Semillas/enzimología Superóxido Dismutasa/metabolismo Superóxidos/metabolismo Análisis de Supervivencia Sustancias Reactivas al Ácido Tiobarbitúrico/metabolismo Factores de Tiempo Agua [Pt] Tipo de publicación: JOURNAL ARTICLE [Nm] Nombre de substancia: 0 (Electrolytes); 0 (Free Radical Scavengers); 0 (Thiobarbituric Acid Reactive Substances); 11062-77-4 (Superoxides); 7722-84-1 (Hydrogen Peroxide); 7732-18-5 (Water); EC 1.15.1.1 (Superoxide Dismutase) [Em] Mes de ingreso: 1009 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 100611 [St] Status: MEDLINE [do] DOI: 10.1111/j.1744-7909.2010.00924.x

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[PMID]: 20183332 [Au] Autor: Dai HF; Gan YJ; Que DM; Wu J; Wen ZC; Mei WL [Ad] Dirección: Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China. [Ti] Título: Two new cytotoxic cardenolides from the latex of Antiaris toxicaria. [So] Fuente: J Asian Nat Prod Res;11(9):832-7, 2009 Sep. [Is] ISSN: 1477-2213 [Cp] País de publicación: England [La] Idioma: eng [Ab] Resumen: Two new cardenolides, toxicarioside F (1) and toxicarioside G (2), were isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Their structures were elucidated on the basis of spectral data and chemical evidence. Compounds 1 and 2 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by the MTT method. [Mh] Términos MeSH primario: Antiaris/química Antineoplásicos Fitogénicos/aislamiento & purificación Antineoplásicos Fitogénicos/farmacología Glicósidos Cardíacos/aislamiento & purificación Glicósidos Cardíacos/farmacología Medicamentos Herbarios Chinos/aislamiento & purificación Medicamentos Herbarios Chinos/farmacología [Mh] Términos MeSH secundario: Antineoplásicos Fitogénicos/química Apoptosis/efectos de drogas Glicósidos Cardíacos/química Ensayos de Selección de Medicamentos Antitumorales Medicamentos Herbarios Chinos/química Células HeLa Humanos Células K562 Látex/química [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (Antineoplastic Agents, Phytogenic); 0 (Cardiac Glycosides); 0 (Drugs, Chinese Herbal); 0 (Latex); 0 (toxicarioside F); 0 (toxicarioside G) [Em] Mes de ingreso: 1004 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 100225 [St] Status: MEDLINE [do] DOI: 10.1080/10286020903164285

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