Base de datos : MEDLINE
Búsqueda : Areca [Palabras]
Referencias encontradas : 1992 [refinar]
Mostrando: 1 .. 10   en el formato [Detallado]

página 1 de 200 va a la página                         

  1 / 1992 MEDLINE  
              next record last record
selecciona
para imprimir
Fotocopia
Texto completo
[PMID]:29385191
[Au] Autor:Chuerduangphui J; Ekalaksananan T; Chaiyarit P; Patarapadungkit N; Chotiyano A; Kongyingyoes B; Promthet S; Pientong C
[Ad] Dirección:Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
[Ti] Título:Effects of arecoline on proliferation of oral squamous cell carcinoma cells by dysregulating c-Myc and miR-22, directly targeting oncostatin M.
[So] Fuente:PLoS One;13(1):e0192009, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Arecoline, the major alkaloid of areca nut, is known to induce oral carcinogenesis, however, its mechanism is still needed to elucidate. This study investigated the effects of arecoline on cell viability and cell-cycle progression of oral squamous cell carcinoma (OSCC) cells as well as a relevant cellular gene expression. The results showed that a low concentration of arecoline (0.025 µg/ml) increased OSCC cell viability, proportion of cells in G2/M phase and cell proliferation. Simultaneously, it induced IL-6, STAT3 and c-Myc expression. Interestingly, c-myc promoter activity was also induced by arecoline. MiR-22 expression in arecoline-treated OSCC cells was suppressed and comparable to an upregulated c-Myc expression. In arecoline-treated OSCC cells, oncostatin M (OSM) expression was significantly upregulated and inversely correlated with miR-22 expression. Likewise, OSM expression and its post-transcriptional activity were significantly decreased in miR-22-transfected OSCC and 293FT cells. This result demonstrated that miR-22 directly targeted OSM. Interestingly, miR-22 played an important role as a tumor suppresser on suppressing cell proliferation, migration and cell-cycle progression of OSCC cells. This result suggested the effect of arecoline to promote cell proliferation and cell-cycle progression of OSCC cells might be involved in induction of c-Myc expression and reduction of miR-22 resulting in OSM upregulation.
[Mh] Términos MeSH primario: Arecolina/farmacología
Carcinoma de Células Escamosas/patología
Proliferación Celular/efectos de los fármacos
MicroARNs/metabolismo
Neoplasias de la Boca/patología
Proteínas Proto-Oncogénicas c-myc/metabolismo
[Mh] Términos MeSH secundario: Carcinoma de Células Escamosas/metabolismo
Ciclo Celular/efectos de los fármacos
Línea Celular Tumoral
Seres Humanos
Interleucina-6/biosíntesis
MicroARNs/genética
Neoplasias de la Boca/metabolismo
Regiones Promotoras Genéticas
Proteínas Proto-Oncogénicas c-myc/genética
Factor de Transcripción STAT3/biosíntesis
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nombre de substancia:
0 (Interleukin-6); 0 (MIRN22 microRNA, human); 0 (MicroRNAs); 0 (Proto-Oncogene Proteins c-myc); 0 (STAT3 Transcription Factor); 0 (STAT3 protein, human); 4ALN5933BH (Arecoline)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0192009


  2 / 1992 MEDLINE  
              first record previous record next record last record
selecciona
para imprimir
Fotocopia
Texto completo
[PMID]:29432841
[Au] Autor:Kim HJ; Ko JW; Cha SB; Heo HS; Seo JH; Cha MJ; Bae JS; Lee HK; Song SW; Kim JC
[Ad] Dirección:Preclinical Research Center, ChemOn Inc., Yongin 17162, Republic of Korea; College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.
[Ti] Título:Evaluation of 13-week repeated oral dose toxicity of Areca catechu in F344/N rats.
[So] Fuente:Food Chem Toxicol;114:41-51, 2018 Feb 10.
[Is] ISSN:1873-6351
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:This study investigated the potential toxicity of the Areca catechu water extract after 13-week repeated oral administration at 0, 166.7, 500, and 1500 mg/kg/day in rats. During the study period, clinical signs, mortality, body weight, food consumption, water consumption, urinalysis, estrous cycle, sperm count and motility, ophthalmoscopy, hematology, serum biochemistry, gross pathology, organ weights, and histopathology were examined. At 1500 mg/kg/day, both sexes exhibited an increase in the incidence of abnormal clinical signs, which included, decreased body weight gain and food consumption, and increased urine bilirubin, ketone bodies, specific gravity, and protein and kidney weight. An increase in liver weight and estrous cycle alterations was observed in females. Serum biochemical and histopathological investigations revealed an increase in the levels of serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase, and the incidence of hepatic necrosis in females. At 500 mg/kg/day, an increase in the incidence of abnormal clinical signs including diarrhea and soiled perineal region, was observed in both sexes. No treatmentrelated effects were observed at 166.7 mg/kg/day. Under the present experimental conditions, the target organs were determined to be the liver, kidney, and female reproductive system in rats. The no-observedeffect level was considered to be 166.7 mg/kg/day in rats.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180308
[Lr] Fecha última revisión:180308
[St] Status:Publisher


  3 / 1992 MEDLINE  
              first record previous record next record last record
selecciona
para imprimir
Fotocopia
Texto completo
[PMID]:29210111
[Au] Autor:Yu CC; Liao YW; Yu CH; Chang YC
[Ad] Dirección:Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan.
[Ti] Título:STRO-1 confers myofibroblast transdifferentiation in fibroblasts derived from oral submucous fibrosis.
[So] Fuente:J Oral Pathol Med;47(3):299-305, 2018 Mar.
[Is] ISSN:1600-0714
[Cp] País de publicación:Denmark
[La] Idioma:eng
[Ab] Resumen:BACKGROUND: STRO-1 is a mesenchymal cell marker present on all clonogenic stromal precursors. Current evidence has indicated that the pathogenesis of fibrotic changes may be mediated by stemness properties. The aim of this study was to investigate the role of STRO-1 in areca quid chewing-associated oral submucous fibrosis (OSF). METHODS: Thirty OSF specimens and ten normal buccal mucosae were examined by immunohistochemistry. The activity of STRO-1 from fibroblasts cultured from normal buccal mucosa (BMFs) and OSF (OSFFs) were measureed and the effect of arecoline, a major areca nut alkaloid, on STRO-1 in BMFs was evaluated. Compared the activities between sorted STRO-1 cells and STRO-1 cells from OSFF were measured by collagen gel contraction, migration, invasion abilities, and the expression of α-smooth muscle actin (α-SMA) and pro-α1 (I) chain of type I collagen. RESULTS: Our results first showed that the expression of STRO-1 was more evident in areca quid chewing-associated OSF than normal buccal mucosa tissues (P < .05). Arecoline dose-dependently activated the level of STRO-1 in BMFs (P < .05). The relative expression of STRO-1 was significantly higher in OSFFs compared with BMFs (P < .05). In addition, the sorted STRO-1 cells from OSFFs exhibited higher collagen gel contraction, migration, and invasion abilities as well as elevated expression of α-SMA and pro-α1 (I) chain of type I collagen than the negative subset (P < .05). CONCLUSION: These findings suggested that the stemness marker STRO-1 may be a crucial factor in the pathogenesis of areca quid chewing-associated OSF.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1712
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[St] Status:In-Process
[do] DOI:10.1111/jop.12668


  4 / 1992 MEDLINE  
              first record previous record next record last record
selecciona
para imprimir
Fotocopia
Texto completo
[PMID]:29241220
[Au] Autor:Yete S; D'Souza W; Saranath D
[Ad] Dirección:Department of Biological Sciences, Sunandan Divatia School of Science, NMIMS (deemed-to-be) University, Mumbai, India.
[Ti] Título:High-Risk Human Papillomavirus in Oral Cancer: Clinical Implications.
[So] Fuente:Oncology;94(3):133-141, 2018.
[Is] ISSN:1423-0232
[Cp] País de publicación:Switzerland
[La] Idioma:eng
[Ab] Resumen:Oral cancer is the eleventh most common cancer globally, with well-established major risk factors of tobacco, areca nut, alcohol, and high-risk human papillomavirus (HR-HPV) types 16 and 18. HR-HPV16/18 are the etiologic agents of cervical cancers and a proportion of oropharyngeal cancers. HPV-associated oropharyngeal and oral cancers show better prognosis and response to therapy. However, the picture of HR-HPV16/18 and the clinical implications of oral cancers are not clear with the majority of reports combining oral cancer data with head and neck cancers. The current review compiles the global prevalence of HR-HPV16/18 in oral cancers, highlighting the unique clinical and molecular pathologic features, prognosis and therapeutic strategies in the prevention and management of HPV-positive oral cancers. The potential for the use of de-intensified therapy and prophylactic prevention in HPV-positive oral cancer patients is highlighted.
[Mh] Términos MeSH primario: Papillomavirus Humano 16/patogenicidad
Papillomavirus Humano 18/patogenicidad
Neoplasias de la Boca/etiología
Neoplasias de la Boca/virología
Infecciones por Papillomavirus/complicaciones
[Mh] Términos MeSH secundario: Seres Humanos
Infecciones por Papillomavirus/virología
Prevalencia
Factores de Riesgo
[Pt] Tipo de publicación:JOURNAL ARTICLE; REVIEW
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180302
[Lr] Fecha última revisión:180302
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:171215
[St] Status:MEDLINE
[do] DOI:10.1159/000485322


  5 / 1992 MEDLINE  
              first record previous record next record last record
selecciona
para imprimir
Fotocopia
Texto completo
[PMID]:29496062
[Au] Autor:Nag R; Kumar Das R
[Ad] Dirección:Centre for Biomaterials, Cellular, and Molecular Theranostics, VIT University, Vellore 632014, India. Electronic address: reetoja.nag2016@vitstudent.ac.in.
[Ti] Título:Analysis of images for detection of oral epithelial dysplasia: A review.
[So] Fuente:Oral Oncol;78:8-15, 2018 Mar.
[Is] ISSN:1879-0593
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:This paper provides a review of various image analysis approaches that have been previously used for recognition of dysplasia in images of the epithelium of the oral cavity. This domain has become especially admissible with the uncovering of the importance of image analysis which can probably be an aid to subjective diagnosis by histopathologists. Oral malignancy is a rampant form of cancer found among people of the Indian subcontinent due to various deleterious habits like consumption of tobacco, areca nut, betel leaf etc. Oral Submucous Fibrosis, a precancer, whose pathological category falls between normal epithelium and epithelial dysplasia, is caused because of these habits and can ultimately lead to oral cancer. Hence early detection of this condition is necessary. Image analysis methods for this purpose have an enormous potential which can also reduce the heavy workload of pathologists and to refine the criterion of interpretation. This paper starts with a critique of statistics of oral carcinoma in India and distribution of cancer in intra-oral sites and moves on to its causes and diagnostic approaches including causative agents, problems in curative approach and importance of image analysis in cancer detection. The various image analysis methods to appraise the cytological and architectural changes accompanied by Oral Epithelial Dysplasia in the images of the oral epithelial region have been described in relation to 2005 WHO Classification System and it was found that in future, analysis of images based on the mentioned methods has the potential in better interpretation and diagnosis of oral carcinoma.
[Pt] Tipo de publicación:JOURNAL ARTICLE; REVIEW
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180302
[Lr] Fecha última revisión:180302
[St] Status:In-Data-Review


  6 / 1992 MEDLINE  
              first record previous record next record last record
selecciona
para imprimir
Fotocopia
Texto completo
[PMID]:29428570
[Au] Autor:Sarode SC; Panta P; Sarode GS; Gadbail AR; Gondivkar SM; Patil S
[Ad] Dirección:Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaramnagar, Pimpri, Pune - 18, Maharashtra, India. Electronic address: drsachinsarode@gmail.com.
[Ti] Título:New research directions for areca nut/betel quid and oral submucous fibrosis for holistic prevention and treatment.
[So] Fuente:Oral Oncol;78:218-219, 2018 Mar.
[Is] ISSN:1879-0593
[Cp] País de publicación:England
[La] Idioma:eng
[Pt] Tipo de publicación:LETTER
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180302
[Lr] Fecha última revisión:180302
[St] Status:In-Data-Review


  7 / 1992 MEDLINE  
              first record previous record next record last record
selecciona
para imprimir
Fotocopia
Texto completo
[PMID]:29348572
[Au] Autor:Faouzi M; Neupane RP; Yang J; Williams P; Penner R
[Ad] Dirección:Center for Biomedical Research, The Queen's Medical Center, Honolulu, HI, 96813, USA. mfaouzi@hawaii.edu.
[Ti] Título:Areca nut extracts mobilize calcium and release pro-inflammatory cytokines from various immune cells.
[So] Fuente:Sci Rep;8(1):1075, 2018 Jan 18.
[Is] ISSN:2045-2322
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Betel nut consumption has significant implications for the public health globally, as the wide-spread habit of Areca chewing throughout Asia and the Pacific is associated with a high prevalence of oral carcinoma and other diseases. Despite a clear causal association of betel nut chewing and oral mucosal diseases, the biological mechanisms that link Areca nut-contained molecules, inflammation and cancer remain underexplored. In this study we show that the whole Areca nut extract (ANE) is capable of mobilizing Ca in various immune cell lines. Interestingly, none of the four major alkaloids or a range of other known constituents of Areca nut were able to induce such Ca signals, suggesting that the active components might represent novel or so far unappreciated chemical structures. The separation of ANE into aqueous and organic fractions has further revealed that the calcium-mobilizing molecules are exclusively present in the aqueous extract. In addition, we found that these calcium signals are associated with the activation of several immune cell lines as shown by the release of pro-inflammatory cytokines and increased cell proliferation. These results indicate that calcium-mobilizing molecules present in the aqueous fraction of the Areca nut may critically contribute to the inflammatory disorders affecting betel nut chewers.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1801
[Cu] Fecha actualización por clase:180211
[Lr] Fecha última revisión:180211
[St] Status:In-Data-Review
[do] DOI:10.1038/s41598-017-18996-2


  8 / 1992 MEDLINE  
              first record previous record next record last record
selecciona
para imprimir
Fotocopia
Texto completo
[PMID]:29209665
[Au] Autor:Shaikh S; Kumar SM
[Ad] Dirección:Department of Oral Diagnosis and Oral Medicine, College of Dentistry, University of Ha'il, Ha'il, Kingdom of Saudi Arabia. E-mail. smrshaikh@gmail.com.
[Ti] Título:Beneficial effects of specific natural substances on oral health.
[So] Fuente:Saudi Med J;38(12):1181-1189, 2017 Dec.
[Is] ISSN:0379-5284
[Cp] País de publicación:Saudi Arabia
[La] Idioma:eng
[Ab] Resumen:Substances that are consumed daily or occasionally may influence an individual's oral health. Some substances, such as alcohol, tobacco, and areca nut, adversely affect the oral region. However, some other substances, such as honey and green tea, which have antimicrobial properties, and berries, which have anticarcinogenic potential, exhibit beneficial effects on oral health. The effectiveness of synthetic drugs in maintaining oral health cannot be ignored; however, the benefits of synthetic drugs are associated with adverse effects and high costs. By contrast, the medicinal use of natural substances is associated with safety, affordability, and long-term benefits. In this paper, we review various natural substances that are potentially beneficial to oral health.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1712
[Cu] Fecha actualización por clase:180207
[Lr] Fecha última revisión:180207
[St] Status:In-Process
[do] DOI:10.15537/smj.2017.12.20516


  9 / 1992 MEDLINE  
              first record previous record next record last record
selecciona
para imprimir
Fotocopia
Texto completo
[PMID]:29376073
[Au] Autor:Chen PH; Mahmood Q; Mariottini GL; Chiang TA; Lee KW
[Ad] Dirección:School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan.
[Ti] Título:Adverse Health Effects of Betel Quid and the Risk of Oral and Pharyngeal Cancers.
[So] Fuente:Biomed Res Int;2017:3904098, 2017.
[Is] ISSN:2314-6141
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Global reports estimate 600 million betel quid (BQ) chewers. BQ chewing has been demonstrated not only to be a risk factor for cancers of the oral cavity and pharynx and oral potentially malignant disorders (OPMD) but also to cause other cancers and adverse health effects. Herein, we summarized the international comparison data to aid in the understanding of the close relationship between the prevalence of BQ chewing, the occurrence of oral and pharyngeal cancers, and adverse health effects. Potential biomarkers of BQ carcinogens, such as areca nut, alkaloids, and 3-methylnitrosaminopropionitrile (MNPN), are closely associated with human health toxicology. Molecular mechanisms or pathways involving autophagy, hypoxia, COX-2, NF- B activity, and stemness are known to be induced by BQ ingredients and are very closely related to the carcinogenesis of cancers of oral and pharynx. BQ abuse-related monoamine oxidase (MAO) gene was associated with the occurrence and progress of oral and pharyngeal cancers. In summary, our review article provides important insights into the potential roles of environmental BQ (specific alkaloid biomarkers and nitrosamine products MNPN) and genetic factors (MAO) and offers a basis for studies aiming to reduce or eliminate BQ-related OPMD and oral/pharyngeal cancer incidences in the future.
[Pt] Tipo de publicación:JOURNAL ARTICLE; REVIEW
[Em] Mes de ingreso:1801
[Cu] Fecha actualización por clase:180129
[Lr] Fecha última revisión:180129
[St] Status:In-Process
[do] DOI:10.1155/2017/3904098


  10 / 1992 MEDLINE  
              first record previous record
selecciona
para imprimir
Fotocopia
Texto completo
[PMID]:29356167
[Au] Autor:Chou CH; Tu HF; Kao SY; Chiang CF; Liu CJ; Chang KW; Lin SC
[Ad] Dirección:Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei, Taiwan.
[Ti] Título:Targeting of miR-31/96/182 to the Numb gene during head and neck oncogenesis.
[So] Fuente:Head Neck;, 2018 Jan 22.
[Is] ISSN:1097-0347
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:BACKGROUND: MicroRNAs (miRNAs) play crucial roles in head and neck squamous cell carcinoma (HNSCC). This study investigates whether miR-31, miR-96, and miR-182 are involved in targeting Numb during HNSCC. METHODS: The expression of miR-31/96/182 in tumor tissues was analyzed. Reporter assay, knockdown, expression, and oncogenic analysis were carried out in cell lines. RESULTS: Upregulation of miR-31/96/182 was detected in tumor tissues. In addition, advanced tumors showed higher expression levels of these miRNAs. The expression of these miRNAs was upregulated after treatment with areca ingredients (P < .01 or P < .001). These miRNAs directly targeted the 3' untranslated region (UTR) sequence of the Numb gene. An increased migration and invasion of HNSCC cells was associated with the exogenous expression of miR-31/96/182 (P < .01 or P < .001), and this was reverted by expression of Numb. CONCLUSION: This study provides new evidence demonstrating that there is frequent and concordant upregulation of miR-31, miR-96, and miR-182 during HNSCC and these miRNAs co-target Numb.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1801
[Cu] Fecha actualización por clase:180122
[Lr] Fecha última revisión:180122
[St] Status:Publisher
[do] DOI:10.1002/hed.25063



página 1 de 200 va a la página                         
   


Refinar la búsqueda
  Base de datos : MEDLINE Formulario avanzado   

    Buscar en el campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPS/OMS - Centro Latinoamericano y del Caribe de Información en Ciencias de la Salud