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[PMID]:28931564
[Au] Autor:Padmanabhan S; Joe B
[Ad] Dirección:Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom; and Center for Hypertension and Personalized Medicine; Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio.
[Ti] Título:Towards Precision Medicine for Hypertension: A Review of Genomic, Epigenomic, and Microbiomic Effects on Blood Pressure in Experimental Rat Models and Humans.
[So] Fuente:Physiol Rev;97(4):1469-1528, 2017 Oct 01.
[Is] ISSN:1522-1210
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Compelling evidence for the inherited nature of essential hypertension has led to extensive research in rats and humans. Rats have served as the primary model for research on the genetics of hypertension resulting in identification of genomic regions that are causally associated with hypertension. In more recent times, genome-wide studies in humans have also begun to improve our understanding of the inheritance of polygenic forms of hypertension. Based on the chronological progression of research into the genetics of hypertension as the "structural backbone," this review catalogs and discusses the rat and human genetic elements mapped and implicated in blood pressure regulation. Furthermore, the knowledge gained from these genetic studies that provide evidence to suggest that much of the genetic influence on hypertension residing within noncoding elements of our DNA and operating through pervasive epistasis or gene-gene interactions is highlighted. Lastly, perspectives on current thinking that the more complex "triad" of the genome, epigenome, and the microbiome operating to influence the inheritance of hypertension, is documented. Overall, the collective knowledge gained from rats and humans is disappointing in the sense that major hypertension-causing genes as targets for clinical management of essential hypertension may not be a clinical reality. On the other hand, the realization that the polygenic nature of hypertension prevents any single locus from being a relevant clinical target for all humans directs future studies on the genetics of hypertension towards an individualized genomic approach.
[Mh] Términos MeSH primario: Epigénesis Genética
Genoma/fisiología
Hipertensión/genética
Hipertensión/patología
Microbiota
[Mh] Términos MeSH secundario: Animales
Humanos
Hipertensión/microbiología
Ratas
[Pt] Tipo de publicación:JOURNAL ARTICLE; REVIEW
[Em] Mes de ingreso:1709
[Cu] Fecha actualización por clase:170928
[Lr] Fecha última revisión:170928
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170921
[St] Status:MEDLINE
[do] DOI:10.1152/physrev.00035.2016


  2 / 956191 MEDLINE  
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[PMID]:28931237
[Au] Autor:Singh V; Prakhar P; Rajmani RS; Mahadik K; Borbora SM; Balaji KN
[Ad] Dirección:Department of Microbiology and Cell Biology, Indian Institute of Science.
[Ti] Título:Histone Methyltransferase SET8 Epigenetically Reprograms Host Immune Responses to Assist Mycobacterial Survival.
[So] Fuente:J Infect Dis;216(4):477-488, 2017 Aug 15.
[Is] ISSN:1537-6613
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:NQO1 and TRXR1 are important host reductases implicated in the regulation of inflammation and apoptosis. Although the transcriptional machinery governing these processes have been extensively investigated, the associated epigenetic regulatory events remain unclear. Here, we report that SET8, a histone H4 lysine 20 monomethylase (H4K20me1), is highly induced during Mycobacterium tuberculosis infection that orchestrates immune evasion strategies through the induction of NQO1 and TRXR1 in vivo. SET8, along with FoxO3a, mediates an active NQO1-PGC1-α complex, which promotes the anti-inflammatory M2 macrophage phenotype, and assists TRXR1-regulated arrest of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Strikingly, the loss-of-function analysis in an in vivo mouse tuberculosis model further corroborated the pivotal role of SET8-responsive NQO1 and TRXR1 in mycobacterial survival. Thus, augmenting host immune responses against Mycobacterium tuberculosis by harnessing the SET8-NQO1/TRXR1 axis with its specific and potent inhibitors could lead to promising host-directed therapeutic adjuvants for tuberculosis treatment.
[Mh] Términos MeSH primario: Epigénesis Genética
N-Metiltransferasa de Histona-Lisina/metabolismo
Interacciones Huésped-Patógeno/genética
Interacciones Huésped-Patógeno/inmunología
Mycobacterium tuberculosis/crecimiento & desarrollo
Tuberculosis/inmunología
[Mh] Términos MeSH secundario: Animales
Apoptosis/efectos de drogas
Modelos Animales de Enfermedad
Proteína Forkhead Box O3/genética
Proteína Forkhead Box O3/metabolismo
Regulación de la Expresión Génica
N-Metiltransferasa de Histona-Lisina/genética
Humanos
Evasión Inmune
Leucocitos Mononucleares/microbiología
Ratones
NAD(P)H Deshidrogenasa (Quinona)/genética
NAD(P)H Deshidrogenasa (Quinona)/metabolismo
Células RAW 264.7
Reproducibilidad de Resultados
Transducción de Señal
Tiorredoxina Reductasa 1/genética
Tiorredoxina Reductasa 1/metabolismo
Tuberculosis/microbiología
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Forkhead Box Protein O3); 0 (FoxO3 protein, mouse); EC 1.6.5.2 (NAD(P)H Dehydrogenase (Quinone)); EC 1.6.5.2 (Nqo1 protein, mouse); EC 1.8.1.9 (Thioredoxin Reductase 1); EC 1.8.1.9 (Txnrd1 protein, mouse); EC 2.1.1.43 (Histone-Lysine N-Methyltransferase); EC 2.1.1.43 (SET8 protein, mouse)
[Em] Mes de ingreso:1709
[Cu] Fecha actualización por clase:170928
[Lr] Fecha última revisión:170928
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:170921
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix322


  3 / 956191 MEDLINE  
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[PMID]:28931235
[Au] Autor:Nielsen TB; Pantapalangkoor P; Luna BM; Bruhn KW; Yan J; Dekitani K; Hsieh S; Yeshoua B; Pascual B; Vinogradov E; Hujer KM; Domitrovic TN; Bonomo RA; Russo TA; Lesczcyniecka M; Schneider T; Spellberg B
[Ad] Dirección:Department of Medicine and Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles.
[Ti] Título:Monoclonal Antibody Protects Against Acinetobacter baumannii Infection by Enhancing Bacterial Clearance and Evading Sepsis.
[So] Fuente:J Infect Dis;216(4):489-501, 2017 Aug 15.
[Is] ISSN:1537-6613
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Background: Extremely drug-resistant (XDR) Acinetobacter baumannii is one of the most commonly encountered, highly resistant pathogens requiring novel therapeutic interventions. Methods: We developed C8, a monoclonal antibody (mAb), by immunizing mice with sublethal inocula of a hypervirulent XDR clinical isolate. Results: C8 targets capsular carbohydrate on the bacterial surface, enhancing opsonophagocytosis. Treating with a single dose of C8 as low as 0.5 µg/mouse (0.0167 mg/kg) markedly improved survival in lethal bacteremic sepsis and aspiration pneumonia models of XDR A. baumannii infection. C8 was also synergistic with colistin, substantially improving survival compared to monotherapy. Treatment with C8 significantly reduced blood bacterial density, cytokine production (tumor necrosis factor α, interleukin [IL] 6, IL-1ß, and IL-10), and sepsis biomarkers. Serial in vitro passaging of A. baumannii in the presence of C8 did not cause loss of mAb binding to the bacteria, but did result in emergence of less-virulent mutants that were more susceptible to macrophage uptake. Finally, we developed a highly humanized variant of C8 that retains opsonophagocytic activity in murine and human macrophages and rescued mice from lethal infection. Conclusions: We describe a promising and novel mAb as therapy for lethal, XDR A. baumannii infections, and demonstrate that it synergistically improves outcomes in combination with antibiotics.
[Mh] Términos MeSH primario: Infecciones por Acinetobacter/quimioterapia
Acinetobacter baumannii/efectos de drogas
Anticuerpos Monoclonales/farmacología
Sepsis/quimioterapia
[Mh] Términos MeSH secundario: Animales
Antibacterianos/farmacología
Biomarcadores/sangre
Colistina/farmacología
Citocinas/sangre
Modelos Animales de Enfermedad
Farmacorresistencia Bacteriana Múltiple
Células HL-60
Humanos
Macrófagos/inmunología
Macrófagos/microbiología
Masculino
Ratones
Ratones Consanguíneos C3H
Sepsis/microbiología
Resultado del Tratamiento
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Anti-Bacterial Agents); 0 (Antibodies, Monoclonal); 0 (Biomarkers); 0 (Cytokines); Z67X93HJG1 (Colistin)
[Em] Mes de ingreso:1709
[Cu] Fecha actualización por clase:170928
[Lr] Fecha última revisión:170928
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:170921
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix315


  4 / 956191 MEDLINE  
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[PMID]:28930833
[Au] Autor:Zawadzki N; Wang Y; Shao H; Liu E; Song C; Schoonmaker M; Shi L
[Ad] Dirección:aGlobal Health Management and Policy, Tulane University, New Orleans, LA bHealthcare Economics and Outcomes Research, Intuitive Surgical, CA cCEPHEID, Sunnyvale.
[Ti] Título:Readmission due to infection following total hip and total knee procedures: A retrospective study.
[So] Fuente:Medicine (Baltimore);96(38):e7961, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Policymakers have expanded readmissions penalty programs to include elective arthroplasties, but little is known about the risk factors for readmissions following these procedures. We hypothesized that infections after total hip arthroplasty (THA) and total knee arthroplasty (TKA) lead to excess readmissions and increased costs. This study aims to evaluate the proportion of readmissions due to infections following THA and TKA.Healthcare Cost and Utilization Project-State Inpatient Databases were used for the study. Procedure codes "8151" and "8154" were used to identify inpatient discharges with THA and TKA in Florida (FL) 2009 to 2013, Massachusetts (MA) 2010 to 2012, and California (CA) 2009 to 2011. Readmission was measured by a Centers for Medicare and Medicaid Services (CMS) validated algorithm. Infections were identified by ICD-9-CM codes: 99859, 99666, 6826, 0389, 486, 4821, 00845, 5990, 48242, 04111, 04112, 04119, 0417, 99591, and 99592. Descriptive analysis was performed.In CA, 4.29% of patients were readmitted with 33.02% of the total readmissions for infection. In FL, 4.7% of patients were readmitted with 33.39% of the readmissions for infection. In MA, 3.92% of patients were readmitted with 35.2% of readmissions for infection. Of the total number of readmissions due to infection, methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible Staphylococcus aureus (MSSA) together accounted for 14.88% in CA, 13.38% in FL, and 13.11% in MA.The rate of infection is similar across all 3 states and is a leading cause for readmission following THA and TKA. Programs to reduce the likelihood of MRSA or MSSA infection would reduce readmissions due to infection.
[Mh] Términos MeSH primario: Artroplastia de Reemplazo de Cadera/efectos adversos
Artroplastia de Reemplazo de Rodilla/efectos adversos
Readmisión del Paciente/estadística & datos numéricos
Complicaciones Posoperatorias/epidemiología
Infecciones Estafilocócicas/epidemiología
[Mh] Términos MeSH secundario: Adulto
Anciano
California/epidemiología
Bases de Datos Factuales
Femenino
Florida/epidemiología
Humanos
Masculino
Massachusetts/epidemiología
Mediana Edad
Complicaciones Posoperatorias/etiología
Complicaciones Posoperatorias/microbiología
Estudios Retrospectivos
Infecciones Estafilocócicas/etiología
Infecciones Estafilocócicas/microbiología
Staphylococcus aureus
[Pt] Tipo de publicación:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mes de ingreso:1709
[Cu] Fecha actualización por clase:170928
[Lr] Fecha última revisión:170928
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:170920
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007961


  5 / 956191 MEDLINE  
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[PMID]:28898366
[Au] Autor:Acree M; Davis AM
[Ad] Dirección:University of Chicago, Chicago, Illinois.
[Ti] Título:Acute Diarrheal Infections in Adults.
[So] Fuente:JAMA;318(10):957-958, 2017 Sep 12.
[Is] ISSN:1538-3598
[Cp] País de publicación:United States
[La] Idioma:eng
[Mh] Términos MeSH primario: Diarrea/quimioterapia
Guías de Práctica Clínica como Asunto
Viaje
[Mh] Términos MeSH secundario: Enfermedad Aguda
Adulto
Antibacterianos/efectos adversos
Antibacterianos/uso terapéutico
Antidiarreicos/uso terapéutico
Diarrea/microbiología
Humanos
Infección/complicaciones
Probióticos/uso terapéutico
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Anti-Bacterial Agents); 0 (Antidiarrheals)
[Em] Mes de ingreso:1709
[Cu] Fecha actualización por clase:170928
[Lr] Fecha última revisión:170928
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:170912
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.8485


  6 / 956191 MEDLINE  
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[PMID]:28881947
[Au] Autor:Murphey Coy R; Held DW; Kloepper JW
[Ad] Dirección:Department of Entomology and Plant Pathology, Auburn University, 301 Funchess Hall, Auburn, AL 36849.
[Ti] Título:Bacterial Inoculant Treatment of Bermudagrass Alters Ovipositional Behavior, Larval and Pupal Weights of the Fall Armyworm (Lepidoptera: Noctuidae).
[So] Fuente:Environ Entomol;46(4):831-838, 2017 Aug 01.
[Is] ISSN:1938-2936
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Nonpathogenic soil bacteria can colonize the rhizosphere and induce unique plant phenotypes that may influence plant-insect interactions. However, few studies have considered the influences of bacteria-plant interactions on insect feeding and oviposition. The objective of this study was to determine how rhizobacterial inoculation of bermudagrass affects larval development and ovipositional behaviors of the fall armyworm (Spodoptera frugiperda J.E. Smith). Eight blends of rhizobacteria known to induce root or shoot growth in grasses were applied weekly to hybrid bermudagrass for 5 wk. Oviposition was evaluated in two no-choice trials with bacteria-treated, fertilized, or nontreated grass. Grass blades from these treatments were extracted in polar and nonpolar solvents and assayed for oviposition responses. Another experiment compared the development of fall armyworm larvae on bermudagrass treated with each of the eight rhizobacterial blends for 5 wk to larvae fed nontreated bermudagrass. Females deposited more eggs on nontreated and fertilized grass and ≤34% of eggs on grass treated with rhizobacterial blends. Moths exposed to polar and nonpolar extracts were unable to reproduce these results. Larval and pupal weights at days 10 and 12 and the number of adults to eclose were lower for larvae fed some, but not all, bacteria-treated bermudagrass relative to controls. This is one of the few studies to investigate plant-microbe-insect interactions in an economically important system. Although the effects noted with fall armyworm are limited, induced changes in roots also reported for these bacteria may have greater utility than foliar changes for mediating interactions with biotic or abiotic stresses.
[Mh] Términos MeSH primario: Inoculantes Agrícolas/química
Bacillales/química
Cynodon/microbiología
Mariposas Nocturnas/microbiología
Mariposas Nocturnas/fisiología
Control Biológico de Vectores
[Mh] Términos MeSH secundario: Animales
Bacillus/química
Brevibacillus/química
Cynodon/crecimiento & desarrollo
Larva/crecimiento & desarrollo
Larva/microbiología
Larva/fisiología
Mariposas Nocturnas/crecimiento & desarrollo
Oviposición
Paenibacillus/química
Pupa/crecimiento & desarrollo
Pupa/microbiología
Pupa/fisiología
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1709
[Cu] Fecha actualización por clase:170928
[Lr] Fecha última revisión:170928
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170908
[St] Status:MEDLINE
[do] DOI:10.1093/ee/nvx102


  7 / 956191 MEDLINE  
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[PMID]:28847317
[Au] Autor:Althouse BM; Hammitt LL; Grant L; Wagner BG; Reid R; Larzelere-Hinton F; Weatherholtz R; Klugman KP; Rodgers GL; O'Brien KL; Hu H
[Ad] Dirección:Institute for Disease Modeling,Bellevue,WA,USA.
[Ti] Título:Identifying transmission routes of Streptococcus pneumoniae and sources of acquisitions in high transmission communities.
[So] Fuente:Epidemiol Infect;145(13):2750-2758, 2017 Oct.
[Is] ISSN:1469-4409
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Identifying the transmission sources and reservoirs of Streptococcus pneumoniae (SP) is a long-standing question for pneumococcal epidemiology, transmission dynamics, and vaccine policy. Here we use serotype to identify SP transmission and examine acquisitions (in the same household, local community, and county, or of unidentified origin) in a longitudinal cohort of children and adults from the Navajo Nation and the White Mountain Apache American Indian Tribes. We found that adults acquire SP relatively more in the household than other age groups, and children 2-8 years old typically acquire in their own or surrounding communities. Age-specific transmission probability matrices show that transmissions within household were mostly seen from older to younger siblings. Outside the household, children most often transmit to other children in the same age group, showing age-assortative mixing behavior. We find toddlers and older children to be most involved in SP transmission and acquisition, indicating their role as key drivers of SP epidemiology. Although infants have high carriage prevalence, they do not play a central role in transmission of SP compared with toddlers and older children. Our results are relevant to inform alternative pneumococcal conjugate vaccine dosing strategies and analytic efforts to inform optimization of vaccine programs, as well as assessing the transmission dynamics of pathogens transmitted by close contact in general.
[Mh] Términos MeSH primario: Portador Sano/epidemiología
Portador Sano/transmisión
Infecciones Neumocócicas/epidemiología
Infecciones Neumocócicas/transmisión
Streptococcus pneumoniae/inmunología
[Mh] Términos MeSH secundario: Adolescente
Adulto
Arizona/epidemiología
Portador Sano/microbiología
Niño
Preescolar
Estudios de Cohortes
Composición Familiar
Femenino
Humanos
Indios Norteamericanos
Lactante
Recién Nacido
Estudios Longitudinales
Masculino
Mediana Edad
Infecciones Neumocócicas/microbiología
Factores de Riesgo
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1709
[Cu] Fecha actualización por clase:170928
[Lr] Fecha última revisión:170928
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170829
[St] Status:MEDLINE
[do] DOI:10.1017/S095026881700125X


  8 / 956191 MEDLINE  
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[PMID]:28813662
[Au] Autor:Sierro F; Evrard M; Rizzetto S; Melino M; Mitchell AJ; Florido M; Beattie L; Walters SB; Tay SS; Lu B; Holz LE; Roediger B; Wong YC; Warren A; Ritchie W; McGuffog C; Weninger W; Le Couteur DG; Ginhoux F; Britton WJ; Heath WR; Saunders BM; McCaughan GW; Luciani F; MacDonald KPA; Ng LG; Bowen DG; Bertolino P
[Ad] Dirección:Centenary Institute and AW Morrow Gastroenterology and Liver Centre, University of Sydney and Royal Prince Alfred Hospital, Sydney, NSW, Australia. Electronic address: frederis@ansto.gov.au.
[Ti] Título:A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment.
[So] Fuente:Immunity;47(2):374-388.e6, 2017 Aug 15.
[Is] ISSN:1097-4180
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:The liver is positioned at the interface between two routes traversed by pathogens in disseminating infection. Whereas blood-borne pathogens are efficiently cleared in hepatic sinusoids by Kupffer cells (KCs), it is unknown how the liver prevents dissemination of peritoneal pathogens accessing its outer membrane. We report here that the hepatic capsule harbors a contiguous cellular network of liver-resident macrophages phenotypically distinct from KCs. These liver capsular macrophages (LCMs) were replenished in the steady state from blood monocytes, unlike KCs that are embryonically derived and self-renewing. LCM numbers increased after weaning in a microbiota-dependent process. LCMs sensed peritoneal bacteria and promoted neutrophil recruitment to the capsule, and their specific ablation resulted in decreased neutrophil recruitment and increased intrahepatic bacterial burden. Thus, the liver contains two separate and non-overlapping niches occupied by distinct resident macrophage populations mediating immunosurveillance at these two pathogen entry points to the liver.
[Mh] Términos MeSH primario: Macrófagos del Hígado/fisiología
Listeria monocytogenes/inmunología
Listeriosis/inmunología
Hígado/inmunología
Macrófagos/inmunología
Neutrófilos/inmunología
Peritoneo/microbiología
[Mh] Términos MeSH secundario: Animales
Comunicación Celular
Autorrenovación de las Células
Interacciones Huésped-Patógeno
Humanos
Inmunidad Innata
Macrófagos del Hígado/microbiología
Hígado/microbiología
Hígado/patología
Macrófagos/microbiología
Ratones
Ratones Consanguíneos C57BL
Ratones Noqueados
Monocitos/inmunología
Infiltración Neutrófila
Peritoneo/patología
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1709
[Cu] Fecha actualización por clase:170928
[Lr] Fecha última revisión:170928
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170816
[St] Status:MEDLINE


  9 / 956191 MEDLINE  
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[PMID]:28805176
[Au] Autor:Saavedra-Campos M; Simone B; Balasegaram S; Wright A; Usdin M; Lamagni T
[Ad] Dirección:Field Epidemiology Service South East and London,Public Health England,London,UK.
[Ti] Título:Estimating the risk of invasive group A Streptococcus infection in care home residents in England, 2009-2010.
[So] Fuente:Epidemiol Infect;145(13):2759-2765, 2017 Oct.
[Is] ISSN:1469-4409
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Invasive group A streptococcal (iGAS) infections cause severe disease and death, especially in residents of long-term care facilities (LTCFs). In order to inform iGAS prevention, we compared the risk of iGAS in LTCF residents and community residents. We identified LTCF residents among cases of iGAS from national surveillance (2009-2010) using postcode matching, and cases of hospital-acquired infections via hospital admission records. We used Poisson regression to calculate incidence rate ratios (IRR) and logistic regression to explore factors associated with case fatality rate (CFR). A total of 2741 laboratory-confirmed iGAS cases were matched to a hospital admission: 156 (6%) were defined as hospital-acquired. Out of the total cases, 96 (3·5%) were LTCF residents. Compared with community residents, LTCF residents over 75 years of age had a higher risk of iGAS infection (IRR = 1·7; 95% CI 1·3-2·1) and CFR (OR = 2·3; 95% CI 1·3-3·8). Amongst community-acquired cases, the risk of iGAS in LTCF residents between 75 and 84 years of age doubled (IRR = 2·7; 95% CI 1·8-3·9) compared with their community counterparts. The CFR among community-acquired cases was higher in LTCF residents than community residents (21% vs. 11%). Age remained associated with death in our final model. Our study showed that, even controlling for age, LTCF residents have a higher risk of acquiring and dying from iGAS. Whilst existing co-morbidities may explain this, it is reasonable to assume that the institutional setting may facilitate transmission. Therefore, cases in LTCF require prompt investigation together with a better understanding of factors contributing to the acquisition of infection.
[Mh] Términos MeSH primario: Infección Hospitalaria/epidemiología
Infecciones Estreptocócicas/epidemiología
Streptococcus pyogenes/fisiología
[Mh] Términos MeSH secundario: Anciano
Anciano de 80 o más Años
Infección Hospitalaria/microbiología
Infección Hospitalaria/mortalidad
Infección Hospitalaria/transmisión
Inglaterra/epidemiología
Femenino
Humanos
Incidencia
Modelos Logísticos
Cuidados a Largo Plazo/estadística & datos numéricos
Masculino
Mortalidad
Distribución de Poisson
Factores de Riesgo
Infecciones Estreptocócicas/microbiología
Infecciones Estreptocócicas/mortalidad
Infecciones Estreptocócicas/transmisión
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1709
[Cu] Fecha actualización por clase:170928
[Lr] Fecha última revisión:170928
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170814
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268817001674


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[PMID]:28805171
[Au] Autor:Zomer TP; VAN Duijkeren E; Wielders CCH; Veenman C; Hengeveld P; VAN DER Hoek W; DE Greeff SC; Smit LAM; Heederik DJ; Yzermans CJ; Kuijper EJ; Maassen CBM
[Ad] Dirección:Centre for Infectious Disease Control (CIb),National Institute for Public Health and the Environment (RIVM),Bilthoven,The Netherlands.
[Ti] Título:Prevalence and risk factors for colonization of Clostridium difficile among adults living near livestock farms in the Netherlands.
[So] Fuente:Epidemiol Infect;145(13):2745-2749, 2017 Oct.
[Is] ISSN:1469-4409
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:A cross-sectional study was performed among 2494 adults not living or working on a farm to assess prevalence of Clostridium difficile (CD) colonization and risk factors in a livestock dense area. CD prevalence was 1·2%. Twenty-one persons were colonized with a toxigenic strain and nine with a non-toxigenic strain. CD-positive persons did not live closer to livestock farms than individuals negative for CD. Antibiotic exposure in the preceding 3 months was a risk factor for CD colonization (odds ratio 3·70; 95% confidence interval 1·25-10·95).
[Mh] Términos MeSH primario: Crianza de Animales Domésticos
Infecciones por Clostridium/epidemiología
Clostridium difficile/fisiología
[Mh] Términos MeSH secundario: Adulto
Anciano
Animales
Antibacterianos/administración & dosificación
Infecciones por Clostridium/quimioterapia
Infecciones por Clostridium/microbiología
Estudios Transversales
Femenino
Humanos
Ganado
Masculino
Mediana Edad
Países Bajos/epidemiología
Prevalencia
Distribución Espacial de la Población
Factores de Riesgo
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Anti-Bacterial Agents)
[Em] Mes de ingreso:1709
[Cu] Fecha actualización por clase:170928
[Lr] Fecha última revisión:170928
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170814
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268817001753



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