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  1 / 967043 MEDLINE  
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[PMID]:29499665
[Au] Autor:Zhu Z; Zhang H; Yue J; Liu S; Li Z; Wang L
[Ad] Dirección:People's Hospital of Zhengzhou University and Henan Provincial People's Hospital, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, 450003, China.
[Ti] Título:Antimicrobial efficacy of corneal cross-linking in vitro and in vivo for Fusarium solani: a potential new treatment for fungal keratitis.
[So] Fuente:BMC Ophthalmol;18(1):65, 2018 Mar 02.
[Is] ISSN:1471-2415
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:BACKGROUND: Fungal keratitis is one of the major causes of visual impairment worldwide. However, the effectiveness of corneal collagen cross-linking (CXL) for fungal keratitis remains controversial. In this study, we developed an in vitro and an in vivo models to assess the efficacy of CXL for Fusarium keratitis. METHODS: The effect of in vitro CXL fungicidal was evaluated on the cultures of Fusarium solani which were exposed to irradiation for different durations. Viability of fungal was appraised under four conditions: no treatment (control); CXL: UVA (365 nm)/riboflavin; riboflavin and UVA (365 nm). Each batch of sterile plate culture was irradiated for different CXL durations. The in vivo Therapeutic effect was studied on a mouse keratitis model. The animals were divided randomly into three groups: group A with no treatment (control); Group B with CXL treatment for two minutes and group C with CXL treatment for three minutes. The CXL procedure was performed 24 h post inoculation in each group. All mice with corneal involvement were scored daily for 7 days and 10 days after infection. Corneals were extracted at various time points for quantitative fungal recovery. Histological evaluations were conducted to calculate the number of polymorphonuclear cells. RESULTS: Viability of fungal decreased significantly in CXL group with 30-min irradiation compared with that in control, riboflavin and UVA groups (P < 0.01). The colony-forming units (CFUs) of fungal solutions in culture significantly decreased with CXL treatment (P < 0.05). Clinical scores, corneal lesion, corneal opacity, neovascularization and the depth of ulceration scores in group B and group C were remarkably lower than that in group A (P < 0.05, P = 0.001, P = 0.001, P = 0.034 and P = 0.025 respectively). Scores of group C were much lower than that in group B. Histological revealed that destruction of corneal collagen fibers and infiltration of inflammatory cells into corneal tissue in group B and group C were much lower than that in group A. CONCLUSIONS: We believe that CXL treatment may be applied to fungal keratitis, therapeutic efficacy will improve with longer treatment duration.
[Mh] Términos MeSH primario: Antiinfecciosos/uso terapéutico
Sustancia Propia/metabolismo
Úlcera de la Córnea/tratamiento farmacológico
Reactivos de Enlaces Cruzados
Infecciones Fúngicas del Ojo/tratamiento farmacológico
Fusariosis/tratamiento farmacológico
Fusarium/efectos de los fármacos
[Mh] Términos MeSH secundario: Animales
Colágeno/metabolismo
Recuento de Colonia Microbiana
Úlcera de la Córnea/metabolismo
Úlcera de la Córnea/microbiología
Modelos Animales de Enfermedad
Infecciones Fúngicas del Ojo/metabolismo
Infecciones Fúngicas del Ojo/microbiología
Fusariosis/metabolismo
Fusariosis/microbiología
Fusarium/aislamiento & purificación
Masculino
Ratones
Ratones Consanguíneos C57BL
Fármacos Fotosensibilizantes/uso terapéutico
Riboflavina/uso terapéutico
Rayos Ultravioleta
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Anti-Infective Agents); 0 (Cross-Linking Reagents); 0 (Photosensitizing Agents); 9007-34-5 (Collagen); TLM2976OFR (Riboflavin)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180304
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0727-0


  2 / 967043 MEDLINE  
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[PMID]:29484749
[Au] Autor:Khosravi AD; Meghdadi H; Ghadiri AA; Alami A; Sina AH; Mirsaeidi M
[Ad] Dirección:Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
[Ti] Título:rpoB gene mutations among Mycobacterium tuberculosis isolates from extrapulmonary sites.
[So] Fuente:APMIS;126(3):241-247, 2018 Mar.
[Is] ISSN:1600-0463
[Cp] País de publicación:Denmark
[La] Idioma:eng
[Ab] Resumen:The aim of this study was to analyze mutations occurring in the rpoB gene of Mycobacterium tuberculosis (MTB) isolates from clinical samples of extrapulmonary tuberculosis (EPTB). Seventy formalin-fixed, paraffin-embedded samples and fresh tissue samples from confirmed EPTB cases were analyzed. Nested PCR based on the rpoB gene was performed on the extracted DNAs, combined with cloning and subsequent sequencing. Sixty-seven (95.7%) samples were positive for nester PCR. Sequence analysis of the 81 bp region of the rpoB gene demonstrated mutations in 41 (61.2%) of 67 sequenced samples. Several point mutations including deletion mutations at codons 510, 512, 513 and 515, with 45% and 51% of the mutations in codons 512 and 513 respectively were seen, along with 26% replacement mutations at codons 509, 513, 514, 518, 520, 524 and 531. The most common alteration was Gln → His, at codon 513, presented in 30 (75.6%) isolates. This study demonstrated sequence alterations in codon 513 of the 81 bp region of the rpoB gene as the most common mutation occurred in 75.6% of molecularly confirmed rifampin-resistant strains. In addition, simultaneous mutation at codons 512 and 513 was demonstrated in 34.3% of the isolates.
[Mh] Términos MeSH primario: Antibióticos Antituberculosos/farmacología
Proteínas Bacterianas/genética
ARN Polimerasas Dirigidas por ADN/genética
Farmacorresistencia Bacteriana/genética
Mycobacterium tuberculosis/genética
Rifampin/farmacología
Tuberculosis/microbiología
[Mh] Términos MeSH secundario: Adulto
Anciano
Anciano de 80 o más Años
Células Cultivadas
Femenino
Seres Humanos
Masculino
Pruebas de Sensibilidad Microbiana
Mediana Edad
Mycobacterium tuberculosis/efectos de los fármacos
Mycobacterium tuberculosis/aislamiento & purificación
Mutación Puntual/genética
Eliminación de Secuencia/genética
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Antibiotics, Antitubercular); 0 (Bacterial Proteins); 0 (rpoB protein, Mycobacterium tuberculosis); EC 2.7.7.6 (DNA-Directed RNA Polymerases); VJT6J7R4TR (Rifampin)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180228
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12804


  3 / 967043 MEDLINE  
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[PMID]:29484747
[Au] Autor:Hirad AH; Ahmad J; Alkhedhairy AA; Bahkali AH; Khan ST
[Ad] Dirección:Botany and Microbiology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
[Ti] Título:Bacterial isolates exhibiting multidrug resistance, hemolytic activity, and high 16S rRNA gene similarity with well-known pathogens found in camel milk samples of Riyadh region.
[So] Fuente:APMIS;126(3):215-226, 2018 Mar.
[Is] ISSN:1600-0463
[Cp] País de publicación:Denmark
[La] Idioma:eng
[Ab] Resumen:Customary consumption of unpasteurized milk by the population in the central Najed region of Saudi Arabia may pose a health risk. Therefore, 80 camel milk samples were collected aseptically from seven different stations of Riyadh region. The biochemical and microbiological properties of these milk samples were determined. Nutrient agar and brain heart infusion agar were used to determine mesophilic aerobic counts (MACs). The MAC in each mL of milk varied from 60 to 16 × 10  CFU/mL on nutrient agar. Based on the colony morphology, 176 colonies were collected from different samples, and these isolates were de-replicated into 80 unique isolates using rep-PCR analysis. Surprisingly, the 16S rRNA sequence analysis of these strains revealed that more than one-third of the collected milk samples contained strains that share maximum sequence similarities with well-known pathogens, such as Brucella, Bacillus anthracis, Listeria monocytogenes, and MRSA. Furthermore, many strains exhibit 16S rRNA gene similarity with opportunistic pathogens such as Citrobacter freundii and Kytococcus schroeteri. Many strains exhibit ß-hemolytic activity and resistant to six different antibiotics. Our study suggested that consumption of raw camel milk from this region constitutes a great health risk.
[Mh] Términos MeSH primario: Bacterias/aislamiento & purificación
Leche/química
Leche/microbiología
[Mh] Términos MeSH secundario: Animales
Bacillus anthracis/genética
Bacillus anthracis/aislamiento & purificación
Bacterias/genética
Carga Bacteriana
Brucella/genética
Brucella/aislamiento & purificación
Camelus
Citrobacter freundii/genética
Citrobacter freundii/aislamiento & purificación
Microbiología de Alimentos
Seres Humanos
Listeria monocytogenes/genética
Listeria monocytogenes/aislamiento & purificación
Staphylococcus aureus Resistente a Meticilina/genética
Staphylococcus aureus Resistente a Meticilina/aislamiento & purificación
Micrococcaceae/genética
Micrococcaceae/aislamiento & purificación
Pasteurización
ARN Ribosómico 16S/genética
Arabia Saudita
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (RNA, Ribosomal, 16S)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180228
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12802


  4 / 967043 MEDLINE  
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[PMID]:29472192
[Au] Autor:Powers JH; Evans SR; Kesselheim AS
[Ad] Dirección:George Washington University School of Medicine, Washington, DC, USA.
[Ti] Título:Studying new antibiotics for multidrug resistant infections: are today's patients paying for unproved future benefits?
[So] Fuente:BMJ;360:k587, 2018 02 22.
[Is] ISSN:1756-1833
[Cp] País de publicación:England
[La] Idioma:eng
[Mh] Términos MeSH primario: Antibacterianos/uso terapéutico
Infecciones Bacterianas/tratamiento farmacológico
Farmacorresistencia Bacteriana Múltiple
[Mh] Términos MeSH secundario: Aprobación de Drogas
Predicción
Seres Humanos
Estados Unidos
United States Food and Drug Administration
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Anti-Bacterial Agents)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:180224
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.k587


  5 / 967043 MEDLINE  
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[PMID]:29462204
[Au] Autor:Li H; Li M; Yang X; Gui X; Chen G; Chu J; He X; Wang W; Han F; Li P
[Ad] Dirección:Research Center for Translational Medicine at Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
[Ti] Título:Microbial diversity and component variation in Xiaguan Tuo Tea during pile fermentation.
[So] Fuente:PLoS One;13(2):e0190318, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Xiaguan Tuo Tea is largely consumed by the Chinese, but there is little research into the microbial diversity and component changes during the fermentation of this tea. In this study, we first used fluorescence in situ hybridization (FISH), next-generation sequencing (NGS) and chemical analysis methods to determine the microbial abundance and diversity and the chemical composition during fermentation. The FISH results showed that the total number of microorganisms ranges from 2.3×102 to 4.0×108 cells per gram of sample during fermentation and is mainly dominated by fungi. In the early fermentation stages, molds are dominant (0.6×102~2.8×106 cells/g, 0~35 d). However, in the late stages of fermentation, yeasts are dominant (3.6×104~9.6×106 cells/g, 35~56 d). The bacteria have little effect during the fermentation of tea (102~103 cells/g, <1% of fungus values). Of these fungi, A. niger (Aspergillus niger) and B. adeninivorans (Blastobotrys adeninivorans) are identified as the two most common strains, based on Next-generation Sequencing (NGS) analysis. Peak diversity in tea was observed at day 35 of fermentation (Shannon-Weaver index: 1.195857), and lower diversity was observed on days 6 and 56 of fermentation (Shannon-Weaver index 0.860589 and 1.119106, respectively). During the microbial fermentation, compared to the unfermented tea, the tea polyphenol content decreased by 54%, and the caffeine content increased by 59%. Theanine and free amino acid contents were reduced during fermentation by 81.1 and 92.85%, respectively.
[Mh] Términos MeSH primario: Fermentación
/microbiología
[Mh] Términos MeSH secundario: Bacterias/aislamiento & purificación
China
Recuento de Colonia Microbiana
Hongos/aislamiento & purificación
Secuenciación de Nucleótidos de Alto Rendimiento
Hibridación Fluorescente in Situ
/metabolismo
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nombre de substancia:
0 (Tea)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190318


  6 / 967043 MEDLINE  
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[PMID]:29447196
[Au] Autor:Verani JR; Massora S; Acácio S; Dos Santos RT; Vubil D; Pimenta F; Moura I; Whitney CG; Costa MH; Macete E; Matsinhe MB; Carvalho MDG; Sigaúque B
[Ad] Dirección:Respiratory Diseases Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, United States of America.
[Ti] Título:Nasopharyngeal carriage of Streptococcus pneumoniae among HIV-infected and -uninfected children <5 years of age before introduction of pneumococcal conjugate vaccine in Mozambique.
[So] Fuente:PLoS One;13(2):e0191113, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Nasopharyngeal carriage is a precursor for pneumococcal disease and can be useful for evaluating pneumococcal conjugate vaccine (PCV) impact. We studied pre-PCV pneumococcal carriage among HIV-infected and -uninfected children in Mozambique. Between October 2012 and March 2013, we enrolled HIV-infected children age <5 years presenting for routine care at seven HIV clinics in 3 sites, including Maputo (urban-south), Nampula (urban-north), and Manhiça (rural-south). We also enrolled a random sample of HIV-uninfected children <5 years old from a demographic surveillance site in Manhiça. A single nasopharyngeal swab was obtained and cultured following enrichment in Todd Hewitt broth with yeast extract and rabbit serum. Pneumococcal isolates were serotyped by Quellung reaction and multiplex polymerase chain reaction. Factors associated with pneumococcal carriage were examined using logistic regression. Overall pneumococcal carriage prevalence was 80.5% (585/727), with similar prevalences among HIV-infected (81.5%, 339/416) and HIV-uninfected (79.1%, 246/311) children, and across age strata. Among HIV-infected, after adjusting for recent antibiotic use and hospitalization, there was no significant association between study site and colonization: Maputo (74.8%, 92/123), Nampula (83.7%, 82/98), Manhiça (84.6%, 165/195). Among HIV-uninfected, report of having been born to an HIV-infected mother was not associated with colonization. Among 601 pneumococcal isolates from 585 children, serotypes 19F (13.5%), 23F (13.1%), 6A (9.2%), 6B (6.2%) and 19A (5.2%) were most common. The proportion of serotypes included in the 10- and 13-valent vaccines was 44.9% and 61.7%, respectively, with no significant differences by HIV status or age group. Overall 36.9% (n = 268) of children were colonized with a PCV10 serotype and 49.7% (n = 361) with a PCV13 serotype. Pneumococcal carriage was common, with little variation by geographic region, age, or HIV status. PCV10 was introduced in April 2013; ongoing carriage studies will examine the benefits of PCV10 among HIV-infected and-uninfected children.
[Mh] Términos MeSH primario: Infecciones Neumocócicas/inmunología
Vacunas Neumococicas/administración & dosificación
Vacunas Neumococicas/uso terapéutico
[Mh] Términos MeSH secundario: Portador Sano/epidemiología
Preescolar
Femenino
Infecciones por VIH/inmunología
Infecciones por VIH/microbiología
Seres Humanos
Lactante
Recién Nacido
Masculino
Pruebas de Sensibilidad Microbiana/métodos
Mozambique/epidemiología
Nasofaringe/inmunología
Infecciones Neumocócicas/fisiopatología
Prevalencia
Población Rural
Serogrupo
Streptococcus pneumoniae/inmunología
Streptococcus pneumoniae/patogenicidad
Vacunas Conjugadas/administración & dosificación
Vacunas Conjugadas/uso terapéutico
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nombre de substancia:
0 (10-valent pneumococcal conjugate vaccine); 0 (Pneumococcal Vaccines); 0 (Vaccines, Conjugate)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191113


  7 / 967043 MEDLINE  
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[PMID]:29446279
[Au] Autor:Anganova EV; Savchenkov MF; Stepanenko LA; Savilov ED
[Ti] Título:[Microbiological monitoring of opportunistic Enterobacteriaceae of the Lena river].
[So] Fuente:Gig Sanit;95(12):1124-8, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicación:Russia (Federation)
[La] Idioma:rus
[Ab] Resumen:The aim is the study of the circulation, biological activity, persistent potential and genotypic characteristics of opportunistic Enterobacteriaceae of microbial community of the Lena River which is the one of the largest sources of water in Russia and Siberia. Gram-negative component of microbial community in the Lena River was mainly represented by Enterobacteriaceae (80%), including dominated Escherichia (dominant class) and Enterobacter and Klebsiella (subdominant class). In conditions of anthropogenic pollution there is a reorganization of microbial community of the Lena River in the direction of the increase in the proportion of opportunistic pathogens, their species diversity; there is a change of the biological activity of microorganisms, gains of share of strains characterized by antilysozyme activity, hemolytic activity, production DNase, phosphatase. The parameters of system "lysozyme-antilysozyme" are changing, the frequency of the occurrence of bacteria with antilysozyme activity is increasing. This shows the restructurization of the microbial community of water objects. Microorganisms of water objects in territories of anthropogenic pollution are characterized by multiple antibiotic resistance. The proportion of gram-negative opportunistic Enterobacteriaceae in microbial communities of water ecosystems determines the potential danger of water objects and the impact on the level of antibiotic resistance of bacteria. Opportunistic Enterobacteriaceae of microbial community of the Lena River near the city of Yakutsk are characterized by the presence of genetic determinants of pathogenicity (hlyA and sfaG). This is indicative of their potential epidemiological relevance. Microorganisms with high biological activity are markers of their epidemiological danger.
[Mh] Términos MeSH primario: Infecciones por Enterobacteriaceae
Enterobacteriaceae
Consorcios Microbianos/fisiología
Ríos/microbiología
Microbiología del Agua/normas
[Mh] Términos MeSH secundario: Enterobacteriaceae/aislamiento & purificación
Enterobacteriaceae/patogenicidad
Enterobacteriaceae/fisiología
Infecciones por Enterobacteriaceae/epidemiología
Infecciones por Enterobacteriaceae/prevención & control
Monitoreo del Ambiente/métodos
Monitoreo del Ambiente/estadística & datos numéricos
Seres Humanos
Siberia/epidemiología
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180216
[St] Status:MEDLINE


  8 / 967043 MEDLINE  
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[PMID]:29431336
[Au] Autor:Rakhmanin; Ivanova LV; Artemova TZ; Gipp EK; Zagainova AV; Maksimkina TN; Krasnyak AV; Schustova SA; Kuznetsova KY; Aslanova MM; Malysheva AG; Abramov EG; Vodyanova MA; Kamenetsky DB; Aleshnya VV
[Ti] Título:[The importance of sanitary microbiological indices in the evaluation of epidemiological safety of water use in conditions of chemical contamination of water].
[So] Fuente:Gig Sanit;95(10):934-8, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicación:Russia (Federation)
[La] Idioma:rus
[Ab] Resumen:The increasing chemicalization of production and life leads to the pollution of water bodies by chemicals, the effect of which on the micro - and macro - organisms is poorly understood. This section of the study in sanitary bacteriology is becoming ever more topical and is an important task of modern hygienic science. One of complicacies of the study of the problem is related with the fact that the presence of only experimental data fails to be sufficient, as the impact of any given chemical substance on different bacteria in the experiment does not mean that under natural conditions, similar results will be obtained. One reason for this may be the inhibitory effect of the given chemical on biological properties of bacteria, while in field conditions in the water several chemicals interacting with each other can exist. In this regard, the aim of the work was to assess the indicator value of sanitary and microbiological indices of epidemic hazard of water use in conditions of chemical pollution of surface water bodies.
[Mh] Términos MeSH primario: Bacterias
Monitoreo del Ambiente
Agua Dulce
Microbiología del Agua/normas
Contaminación Química del Agua
[Mh] Términos MeSH secundario: Bacterias/clasificación
Bacterias/efectos de los fármacos
Bacterias/aislamiento & purificación
Bacterias/patogenicidad
Industria Química/estadística & datos numéricos
Monitoreo del Ambiente/métodos
Monitoreo del Ambiente/normas
Agua Dulce/análisis
Agua Dulce/química
Agua Dulce/microbiología
Seres Humanos
Moscú/epidemiología
Salud Pública/métodos
Salud Pública/normas
Contaminantes Químicos del Agua/efectos adversos
Contaminantes Químicos del Agua/análisis
Contaminantes Químicos del Agua/clasificación
Contaminación Química del Agua/análisis
Contaminación Química del Agua/prevención & control
Abastecimiento de Agua/normas
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Water Pollutants, Chemical)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180213
[St] Status:MEDLINE


  9 / 967043 MEDLINE  
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[PMID]:29431324
[Au] Autor:Fedorenko EV; Kolomiets ND; Sychik SI
[Ti] Título:[Actual problems of the microbiological safety of food products].
[So] Fuente:Gig Sanit;95(9):873-8, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicación:Russia (Federation)
[La] Idioma:rus
[Ab] Resumen:Food-borne infectious diseases remain an actual problem of health care. In the Republic of Belarus the level of food-borne diseases persists to be stable, at the same time these diseases remain to be significant. Despite the insignificant number of nonconforming food samples the prevalence rates of food-borne acute infectious diseases of various etiology with dominantly food transmission pathway remain to be rather high. The mentioned fact determines the need for the development of approaches on the security of microbiological food safety based on the risk analysis. There are determined criteria for a hygienic assessment of the microbiological hazards (associated with the pathogen, food products and a consumer health state), there is presented the classification offood products in dependence on the grade of microbiological risk. There was performed the comparative analysis of requirements for the microbiological safety of food accepted in the Republic of Belarus and European Economic Union, in the European Union and at the international level, which testify to the presence of separate differences. Based on the international approaches there was substantiated the multilevel control system of management of microbiological risks, there is reported the characteristic of separate criteria. There are determined the directions of the improvement of the security of microbiological safety of food.
[Mh] Términos MeSH primario: Contaminación de Alimentos
Manipulación de Alimentos
Microbiología de Alimentos
Enfermedades Transmitidas por los Alimentos
[Mh] Términos MeSH secundario: Contaminación de Alimentos/análisis
Contaminación de Alimentos/prevención & control
Manipulación de Alimentos/métodos
Manipulación de Alimentos/normas
Microbiología de Alimentos/métodos
Microbiología de Alimentos/normas
Calidad de los Alimentos
Enfermedades Transmitidas por los Alimentos/epidemiología
Enfermedades Transmitidas por los Alimentos/microbiología
Enfermedades Transmitidas por los Alimentos/prevención & control
Seres Humanos
Salud Pública/métodos
Salud Pública/normas
República de Belarús/epidemiología
Medición de Riesgo/métodos
Factores de Riesgo
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180213
[St] Status:MEDLINE


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[PMID]:29424453
[Au] Autor:Esenboga S; Cagdas D; Ozgur TT; Gur Cetinkaya P; Turkdemir LM; Sanal O; VanDerBurg M; Tezcan I
[Ad] Dirección:Department of Pediatrics, Division of Immunology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
[Ti] Título:Clinical and genetic features of the patients with X-Linked agammaglobulinemia from Turkey: Single-centre experience.
[So] Fuente:Scand J Immunol;87(3), 2018 Mar.
[Is] ISSN:1365-3083
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:X-linked agammaglobulinemia is a primary immunodeficiency disorder resulting from BTK gene mutations. There are many studies in the literature suggesting contradictory ideas about phenotype-genotype correlation. The aim of this study was to identify the mutations and clinical findings of patients with XLA in Turkey, to determine long-term complications related to the disease and to analyse the phenotype-genotype correlation. Thirty-two patients with XLA diagnosed between 1985 and 2016 in Pediatric Immunology Department of Hacettepe University Ihsan Dogramaci Children's Hospital were investigated. A clinical survey including clinical features of the patients was completed, and thirty-two patients from 26 different families were included in the study. Getting early diagnosis and regular assessment with imaging techniques seem to be the most important issues for improving the health status of the patients with XLA. Early molecular analysis gives chance for definitive diagnosis and genetic counselling, but not for predicting the clinical severity and prognosis.
[Mh] Términos MeSH primario: Agammaglobulinemia/diagnóstico
Agammaglobulinemia/genética
Anticuerpos/sangre
Enfermedades Genéticas Ligadas al Cromosoma X/diagnóstico
Enfermedades Genéticas Ligadas al Cromosoma X/genética
Proteínas Tirosina Quinasas/genética
[Mh] Términos MeSH secundario: Adolescente
Adulto
Agammaglobulinemia/patología
Infecciones Bacterianas/inmunología
Niño
Preescolar
Enfermedades Genéticas Ligadas al Cromosoma X/patología
Seres Humanos
Inmunoglobulina A/sangre
Inmunoglobulina G/sangre
Inmunoglobulina M/sangre
Lactante
Estudios Retrospectivos
Turquia
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Antibodies); 0 (Immunoglobulin A); 0 (Immunoglobulin G); 0 (Immunoglobulin M); EC 2.7.10.1 (Agammaglobulinaemia tyrosine kinase); EC 2.7.10.1 (Protein-Tyrosine Kinases)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180210
[St] Status:MEDLINE
[do] DOI:10.1111/sji.12647



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