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  1 / 945961 MEDLINE  
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[PMID]:28688574
[Au] Autor:Shimizu Y; Hidaka H; Ozawa D; Kakuta R; Nomura K; Yano H; Watanabe KI; Katori Y
[Ad] Dirección:Department of Otolaryngology - Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
[Ti] Título:Clinical and bacteriological differences of deep neck infection in pediatric and adult patients: Review of 123 cases.
[So] Fuente:Int J Pediatr Otorhinolaryngol;99:95-99, 2017 Aug.
[Is] ISSN:1872-8464
[Cp] País de publicación:Ireland
[La] Idioma:eng
[Ab] Resumen:OBJECTIVES: Deep neck infections (DNIs) can lead to life-threatening disease. However, the detailed pathophysiology remains unclear due to its rarity and only a few reports have directly compared DNIs in children and adults. This study aimed to reveal the clinical differences between DNIs in children and adults. METHODS: We retrospectively reviewed 123 patients who suffered from DNIs at Tohoku University Hospital from August 2005 to July 2015. We extracted data on patient sex, age, antecedent illness, extension of infections, operative procedures, and bacteriology results. The patients were categorized into pediatric (≤18 years) and adult (>18 years) groups. Fisher's exact test was performed to determine significant differences between the two groups. RESULTS: Fifteen children (6 males and 9 females) and 108 adults (71 males and 37 females) were identified. The most common antecedent illness in pediatric patients was lymphadenitis, which was the least common in adult patients (73% vs 7%, p < 0.0001). The incidence of DNIs extending below the hyoid bone was significantly lower in pediatric patients than in adult patients (20% vs 53%, p < 0.05). Regarding bacterial culture analysis, Staphylococcus species was the most common pathogen in children (60%), whereas only 9% of adults were positive for Staphylococcus (p < 0.001). Streptococcus species were significantly less common in children than in adults (27% vs 56%, p = 0.05). Anaerobes were also significantly less common in children than in adults (13% vs 45%, p < 0.01). Concerning surgical intervention, 53% of pediatric patients underwent external incision compared with 70% of adults. Specifically, tracheostomy was significantly less frequently performed in children than in adults (7% vs 54%, p < 0.01). CONCLUSION: DNIs in children feature different characteristics from those in adults regarding severity, antecedent illness, bacteriology, and clinical management.
[Mh] Términos MeSH primario: Infección/microbiología
Cuello/microbiología
[Mh] Términos MeSH secundario: Adolescente
Adulto
Anciano
Anciano de 80 o más Años
Niño
Preescolar
Manejo de la Enfermedad
Femenino
Humanos
Incidencia
Lactante
Infección/diagnóstico
Masculino
Mediana Edad
Estudios Retrospectivos
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1708
[Cu] Fecha actualización por clase:170803
[Lr] Fecha última revisión:170803
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170709
[St] Status:MEDLINE


  2 / 945961 MEDLINE  
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[PMID]:28688554
[Au] Autor:Côrte FC; Firmino-Machado J; Moura CP; Spratley J; Santos M
[Ad] Dirección:Department of Otorhinolaryngology, Hospital de São João EPE, Porto, Portugal; University of Porto Medical School, Porto, Portugal. Electronic address: filipacamachocorte@gmail.com.
[Ti] Título:Acute pediatric neck infections: Outcomes in a seven-year series.
[So] Fuente:Int J Pediatr Otorhinolaryngol;99:128-134, 2017 Aug.
[Is] ISSN:1872-8464
[Cp] País de publicación:Ireland
[La] Idioma:eng
[Ab] Resumen:OBJECTIVES: The aim of this study was to analyse the epidemiology, clinical presentation, diagnostic clues, as biochemical parameters and imaging studies, of children with acute neck infections (ANI) to identify possible independent prognostic factors leading to complications and prolonged hospitalization. METHODS: Records of children admitted to a tertiary university hospital from January 2008 to December 2014 with a diagnosis of ANIs were reviewed retrospectively. Diseases were categorized according to the site of infection and patients were divided into two groups: children (aged<10 years) and adolescents (aged 10-18 years). RESULTS: A total of 102 patients belonged to the children's group and 57 were adolescents. Forty-nine patients (27.2%) received antibiotics prior to presentation. The most frequent ANI was peritonsillar abscess (n = 72). Four peritonsillar abscesses progressed to parapharyngeal and retropharyngeal abscesses (n = 2 respectively). An association between age and type of abscess was found, with most of the retropharyngeal abscesses occurring in children (p = 0.05), and the submandibular abscesses in adolescents (p < 0.001). The most frequent symptoms/signs were fever (63.9%) and odynophagia (50.6%). Upon admission, all patients received intravenous antibiotics and 86.8% underwent drainage of the abscess. Cultures were harvested in 87 abscesses and the most frequent pathogen isolated was Streptococcus pyogenes. Signs of airway obstruction occurred in two patients with submandibular abscess, one with peritonsillar and one with parapharyngeal abscess. There were no cases of death or severe sequelae. Recurrent ANIs were observed in eight patients including two infected branchial cysts. Children, presence of multiple abscesses and palpable cervical mass on admission, absence of odynophagia and pharyngeal bulging, surgery with general anaesthesia and surgery after 24 h, were associated with prolonged hospitalization. Presence of toothache and neck pain on admission were identified as predictors of complications. CONCLUSIONS: The present study found, that often, the diagnosis and treatment of neck abscesses in paediatric patients is not straightforward, but can achieve a favourable outcome. The primary location of the ANI appears to vary in different paediatric age groups. Younger age, presence of multiple abscesses or a palpable cervical mass on admission, were associated with prolonged hospitalization. Presence of toothache and neck pain on admission was identified as possible predictors of complications.
[Mh] Términos MeSH primario: Absceso/diagnóstico
Infección/complicaciones
Cuello/patología
[Mh] Términos MeSH secundario: Absceso/complicaciones
Absceso/terapia
Enfermedad Aguda
Adolescente
Antibacterianos/uso terapéutico
Niño
Preescolar
Drenaje
Femenino
Hospitalización
Humanos
Lactante
Infección/terapia
Masculino
Cuello/microbiología
Estudios Retrospectivos
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Anti-Bacterial Agents)
[Em] Mes de ingreso:1708
[Cu] Fecha actualización por clase:170803
[Lr] Fecha última revisión:170803
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170709
[St] Status:MEDLINE


  3 / 945961 MEDLINE  
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[PMID]:28688551
[Au] Autor:Vinh D; Yim M; Dutta A; Jones JK; Zhang W; Sitton M
[Ad] Dirección:Baylor College of Medicine Department of Otolaryngology-Head & Neck Surgery, Houston, TX, USA. Electronic address: daniel.vinh@bcm.edu.
[Ti] Título:Pediatric invasive fungal rhinosinusitis: An investigation of 17 patients.
[So] Fuente:Int J Pediatr Otorhinolaryngol;99:111-116, 2017 Aug.
[Is] ISSN:1872-8464
[Cp] País de publicación:Ireland
[La] Idioma:eng
[Ab] Resumen:PURPOSE: To investigate outcomes of pediatric patients at a single institution with invasive fungal rhinosinusitis (IFRS) and to determine variables that impact overall survival. METHODS: All pediatric patients at a large tertiary children's hospital diagnosed with IFRS confirmed by surgical pathology from 2009 to 2015 were retrospectively reviewed. Demographics, underlying diseases, symptoms, antifungal therapy, absolute neutrophil count (ANC), surgical management,and outcomes were analyzed. RESULTS: Seventeen patients were identified with IFRS with an average age of 8.7 years and 53% male. Hematologic malignancy was the most common (n = 13) underlying disease. The most common presenting symptoms were fever (82%) and congestion (41%). 15 patients had severe neutropenia (Absolute Neutrophil Count (ANC) < 500) within 2 weeks prior to diagnosis. The average ANC at time of diagnosis was 1420 cells/uL. 16 patients were treated with serial nasal endoscopy and debridement, while 1 patient was treated with an open approach. 16 received combination antifungals while 1 was treated with amphotericin monotherapy. The most common genus cultured was Fusarium (n = 6). The average number of surgical interventions was 3.4, with the average interval between interventions 6.2 days. 13 of 17 (76%) were cleared of IFRS. Overall survival at 6 months was 41%. CONCLUSION: Pediatric IFRS is a life-threatening disease that requires a coordinated surgical and medical approach. Despite a relatively high local control rate, overall mortality remains disappointingly high, reflecting the disease's underlying pathogenesis - lack of host defense and risk of disseminated fungal infection. Further investigation is necessary to reveal optimal management with regards to antifungal therapy, surgery, and utility of labs.
[Mh] Términos MeSH primario: Antifúngicos/uso terapéutico
Micosis/diagnóstico
Rinitis/microbiología
Sinusitis/microbiología
[Mh] Términos MeSH secundario: Adolescente
Niño
Preescolar
Desbridamiento
Endoscopía
Femenino
Humanos
Lactante
Masculino
Micosis/mortalidad
Micosis/terapia
Estudios Retrospectivos
Rinitis/mortalidad
Rinitis/terapia
Sinusitis/mortalidad
Sinusitis/terapia
Tasa de Supervivencia
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Antifungal Agents)
[Em] Mes de ingreso:1708
[Cu] Fecha actualización por clase:170803
[Lr] Fecha última revisión:170803
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170709
[St] Status:MEDLINE


  4 / 945961 MEDLINE  
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[PMID]:28661330
[Au] Autor:Chidamba L; Cilliers E; Bezuidenhout CC
[Ad] Dirección:Unit for Environmental Science and Management, North-West University: Potchefstroom Campus, Potchefstroom 2520, South Africa.
[Ti] Título:Spatial and Temporal Variations in Pollution Indicator Bacteria in the Lower Vaal River, South Africa.
[So] Fuente:Water Environ Res;88(11):2142-2149, 2016 Nov 01.
[Is] ISSN:1061-4303
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:The aim of this study was to evaluate the spatial and temporal variation of microbiological parameters of the Lower Vaal River, with emphasis on the Staphylococci population. River water concentrations of Staphylococci, heterotrophic, total coliforms, fecal coliforms and Streptococci groups of sanitary indicator bacteria were monitored. Results indicated significant contamination from agricultural land use inputs and municipal waste applications. Significant temporal and spatial variation was observed in response to the varying river discharge. Higher microbial concentrations were detected during high river discharge whereas during low river discharge both low and high microbial concentrations were detected. The varying responses associated with river discharge helped to identify the importance of different sources of contamination in the catchment and the mechanisms transferring them. The overall impact of contamination on the water quality of the Vaal River could have potentially serious public health risks but also provide valuable data for integrated water resource management.
[Mh] Términos MeSH primario: Monitoreo del Ambiente/métodos
Ríos/microbiología
Microbiología del Agua
Contaminación del Agua
Calidad del Agua
[Mh] Términos MeSH secundario: Ríos/química
Sudáfrica
Factores de Tiempo
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1708
[Cu] Fecha actualización por clase:170803
[Lr] Fecha última revisión:170803
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170629
[St] Status:MEDLINE
[do] DOI:10.2175/106143016X14733681695528


  5 / 945961 MEDLINE  
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[PMID]:28661325
[Au] Autor:Soboh YM; Sorensen DL; Sims RC
[Ad] Dirección:Department of Biological Engineering, Utah State University, Logan, Utah 84322, USA.
[Ti] Título:Upflow Anaerobic Sludge Blanket Reactor Codigestion of Algae and Acetate to Produce Methane.
[So] Fuente:Water Environ Res;88(11):2094-2103, 2016 Nov 01.
[Is] ISSN:1061-4303
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Algae grown in wastewater treatment lagoons are a potentially important substrate for biofuel production. The feasibility of using upflow anaerobic sludge blanket (UASB) reactors in anaerobic digestion of algae to produce methane was investigated. A favorable carbon to nitrogen (C/N) weight ratio of 21/1 was determined in batch reactor experiments in which the ratio was adjusted by blending algal biomass with sodium acetate as a carbon source. This blend of algae and acetate was used in the feedstock applied to the UASB reactors. Duplicate, 34-L, UASB reactors initially received an organic loading rate (OLR) of 0.9 g chemical oxygen demand (COD)/L.d at a 7.2-day hydraulic retention time (HRT). The OLR was gradually increased to 5.4 g/L.d and the HRT was decreased to 5.5 days resulting in a methane production increase from 247 to 298 mL/g COD biodegraded. The COD removal efficiency was 80% with a biogas methane composition of 90%.
[Mh] Términos MeSH primario: Reactores Biológicos
Cianobacterias/química
Metano/química
Acetato de Zinc/química
[Mh] Términos MeSH secundario: Anaerobiosis
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
FM5526K07A (Zinc Acetate); OP0UW79H66 (Methane)
[Em] Mes de ingreso:1708
[Cu] Fecha actualización por clase:170803
[Lr] Fecha última revisión:170803
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170629
[St] Status:MEDLINE
[do] DOI:10.2175/106143016X14733681695645


  6 / 945961 MEDLINE  
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[PMID]:28622509
[Au] Autor:Maffioli SI; Zhang Y; Degen D; Carzaniga T; Del Gatto G; Serina S; Monciardini P; Mazzetti C; Guglierame P; Candiani G; Chiriac AI; Facchetti G; Kaltofen P; Sahl HG; Dehò G; Donadio S; Ebright RH
[Ad] Dirección:NAICONS Srl, 20139 Milan, Italy; Vicuron Pharmaceuticals, 21040 Gerenzano, Italy.
[Ti] Título:Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase.
[So] Fuente:Cell;169(7):1240-1248.e23, 2017 Jun 15.
[Is] ISSN:1097-4172
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Drug-resistant bacterial pathogens pose an urgent public-health crisis. Here, we report the discovery, from microbial-extract screening, of a nucleoside-analog inhibitor that inhibits bacterial RNA polymerase (RNAP) and exhibits antibacterial activity against drug-resistant bacterial pathogens: pseudouridimycin (PUM). PUM is a natural product comprising a formamidinylated, N-hydroxylated Gly-Gln dipeptide conjugated to 6'-amino-pseudouridine. PUM potently and selectively inhibits bacterial RNAP in vitro, inhibits bacterial growth in culture, and clears infection in a mouse model of Streptococcus pyogenes peritonitis. PUM inhibits RNAP through a binding site on RNAP (the NTP addition site) and mechanism (competition with UTP for occupancy of the NTP addition site) that differ from those of the RNAP inhibitor and current antibacterial drug rifampin (Rif). PUM exhibits additive antibacterial activity when co-administered with Rif, exhibits no cross-resistance with Rif, and exhibits a spontaneous resistance rate an order-of-magnitude lower than that of Rif. PUM is a highly promising lead for antibacterial therapy.
[Mh] Términos MeSH primario: Antibacterianos/aislamiento & purificación
Antibacterianos/farmacología
ARN Polimerasas Dirigidas por ADN/antagonistas & inhibidores
Streptomyces/química
[Mh] Términos MeSH secundario: Animales
Antibacterianos/química
Bacterias/clasificación
Bacterias/efectos de drogas
Bacterias/crecimiento & desarrollo
ARN Polimerasas Dirigidas por ADN/química
Farmacorresistencia Bacteriana
Femenino
Células HeLa
Humanos
Ratones
Ratones Consanguíneos ICR
Microbiología del Suelo
Infecciones Estreptocócicas/quimioterapia
Streptococcus pyogenes/efectos de drogas
Transcripción Genética/efectos de drogas
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Anti-Bacterial Agents); EC 2.7.7.6 (DNA-Directed RNA Polymerases)
[Em] Mes de ingreso:1707
[Cu] Fecha actualización por clase:170804
[Lr] Fecha última revisión:170804
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170616
[St] Status:MEDLINE


  7 / 945961 MEDLINE  
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[PMID]:28559279
[Au] Autor:Loiseau L; Fyfe C; Aussel L; Hajj Chehade M; Hernández SB; Faivre B; Hamdane D; Mellot-Draznieks C; Rascalou B; Pelosi L; Velours C; Cornu D; Lombard M; Casadesús J; Pierrel F; Fontecave M; Barras F
[Ad] Dirección:From the Aix Marseille Université, CNRS, Laboratoire de Chimie Bactérienne (LCB) UMR 7283, Institut de Microbiologie de la Méditerranée (IMM), 13402, Marseille, France.
[Ti] Título:The UbiK protein is an accessory factor necessary for bacterial ubiquinone (UQ) biosynthesis and forms a complex with the UQ biogenesis factor UbiJ.
[So] Fuente:J Biol Chem;292(28):11937-11950, 2017 Jul 14.
[Is] ISSN:1083-351X
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Ubiquinone (UQ), also referred to as coenzyme Q, is a widespread lipophilic molecule in both prokaryotes and eukaryotes in which it primarily acts as an electron carrier. Eleven proteins are known to participate in UQ biosynthesis in , and we recently demonstrated that UQ biosynthesis requires additional, nonenzymatic factors, some of which are still unknown. Here, we report on the identification of a bacterial gene, , which is required for efficient UQ biosynthesis, and which we have renamed Using several methods, we demonstrated that the UbiK protein forms a complex with the C-terminal part of UbiJ, another UQ biogenesis factor we previously identified. We found that both proteins are likely to contribute to global UQ biosynthesis rather than to a specific biosynthetic step, because both ubiK and ubiJ mutants accumulated octaprenylphenol, an early intermediate of the UQ biosynthetic pathway. Interestingly, we found that both proteins are dispensable for UQ biosynthesis under anaerobiosis, even though they were expressed in the absence of oxygen. We also provide evidence that the UbiK-UbiJ complex interacts with palmitoleic acid, a major lipid in Last, in , ubiK was required for proliferation in macrophages and virulence in mice. We conclude that although the role of the UbiK-UbiJ complex remains unknown, our results support the hypothesis that UbiK is an accessory factor of Ubi enzymes and facilitates UQ biosynthesis by acting as an assembly factor, a targeting factor, or both.
[Mh] Términos MeSH primario: Proteínas Bacterianas/metabolismo
Proteínas Portadoras/metabolismo
Proteínas de Escherichia coli/metabolismo
Escherichia coli/metabolismo
Macrófagos/microbiología
Modelos Moleculares
Salmonella enterica/metabolismo
Ubiquinona/biosíntesis
[Mh] Términos MeSH secundario: Animales
Células 3T3 BALB
Carga Bacteriana
Proteínas Bacterianas/química
Proteínas Bacterianas/genética
Proteínas Portadoras/química
Proteínas Portadoras/genética
Escherichia coli/crecimiento & desarrollo
Proteínas de Escherichia coli/química
Proteínas de Escherichia coli/genética
Ácidos Grasos Monoinsaturados/metabolismo
Femenino
Eliminación de Gen
Humanos
Macrófagos/inmunología
Ratones
Fragmentos de Péptidos/química
Fragmentos de Péptidos/genética
Fragmentos de Péptidos/metabolismo
Dominios y Motivos de Interacción de Proteínas
Multimerización de Proteína
Células RAW 264.7
Proteínas Recombinantes de Fusión/química
Proteínas Recombinantes de Fusión/metabolismo
Proteínas Recombinantes/química
Proteínas Recombinantes/metabolismo
Infecciones por Salmonella/microbiología
Salmonella enterica/crecimiento & desarrollo
Salmonella enterica/aislamiento & purificación
Salmonella enterica/patogenicidad
Bazo/microbiología
Terminología como Asunto
Virulencia
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Bacterial Proteins); 0 (Carrier Proteins); 0 (Escherichia coli Proteins); 0 (Fatty Acids, Monounsaturated); 0 (Peptide Fragments); 0 (Recombinant Fusion Proteins); 0 (Recombinant Proteins); 0 (UbiJ protein, E coli); 0 (UbiK protein, E coli); 1339-63-5 (Ubiquinone); 209B6YPZ4I (palmitoleic acid)
[Em] Mes de ingreso:1708
[Cu] Fecha actualización por clase:170803
[Lr] Fecha última revisión:170803
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170531
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M117.789164


  8 / 945961 MEDLINE  
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[PMID]:28559277
[Au] Autor:Chitty JL; Blake KL; Blundell RD; Koh YQAE; Thompson M; Robertson AAB; Butler MS; Cooper MA; Kappler U; Williams SJ; Kobe B; Fraser JA
[Ad] Dirección:From the Australian Infectious Diseases Research Centre, School of Chemistry & Molecular Biosciences.
[Ti] Título: ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design.
[So] Fuente:J Biol Chem;292(28):11829-11839, 2017 Jul 14.
[Is] ISSN:1083-351X
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:There is significant clinical need for new antifungal agents to manage infections with pathogenic species such as Because the purine biosynthesis pathway is essential for many metabolic processes, such as synthesis of DNA and RNA and energy generation, it may represent a potential target for developing new antifungals. Within this pathway, the bifunctional enzyme adenylosuccinate (ADS) lyase plays a role in the formation of the key intermediates inosine monophosphate and AMP involved in the synthesis of ATP and GTP, prompting us to investigate ADS lyase in Here, we report that encodes ADS lyase in We found that an Δ mutant is an adenine auxotroph and is unable to successfully cause infections in a murine model of virulence. Plate assays revealed that production of a number of virulence factors essential for dissemination and survival of in a host environment was compromised even with the addition of exogenous adenine. Purified recombinant ADS lyase shows catalytic activity similar to its human counterpart, and its crystal structure, the first fungal ADS lyase structure determined, shows a high degree of structural similarity to that of human ADS lyase. Two potentially important amino acid differences are identified in the crystal structure, in particular a threonine residue that may serve as an additional point of binding for a fungal enzyme-specific inhibitor. Besides serving as an antimicrobial target, ADS lyase inhibitors may also serve as potential therapeutics for metabolic disease; rather than disrupt ADS lyase, compounds that improve the stability the enzyme may be used to treat ADS lyase deficiency disease.
[Mh] Términos MeSH primario: Adenilosuccinato Liasa/antagonistas & inhibidores
Antifúngicos/farmacología
Cryptococcus neoformans/enzimología
Diseño de Drogas
Inhibidores Enzimáticos/farmacología
Proteínas Fúngicas/antagonistas & inhibidores
Modelos Moleculares
[Mh] Términos MeSH secundario: Adenilosuccinato Liasa/química
Adenilosuccinato Liasa/genética
Adenilosuccinato Liasa/metabolismo
Secuencia de Aminoácidos
Animales
Antifúngicos/química
Antifúngicos/uso terapéutico
Sitios de Unión
Criptococosis/quimioterapia
Criptococosis/metabolismo
Criptococosis/microbiología
Cryptococcus neoformans/efectos de drogas
Cryptococcus neoformans/genética
Cryptococcus neoformans/patogenicidad
Cristalografía por Rayos X
Inhibidores Enzimáticos/química
Inhibidores Enzimáticos/uso terapéutico
Femenino
Proteínas Fúngicas/química
Proteínas Fúngicas/genética
Proteínas Fúngicas/metabolismo
Eliminación de Gen
Ratones Consanguíneos BALB C
Conformación Molecular
Conformación Proteica
Proteínas Recombinantes de Fusión/química
Proteínas Recombinantes de Fusión/metabolismo
Alineación de Secuencia
Homología Estructural de Proteína
Análisis de Supervivencia
Virulencia/efectos de drogas
[Pt] Tipo de publicación:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Antifungal Agents); 0 (Enzyme Inhibitors); 0 (Fungal Proteins); 0 (Recombinant Fusion Proteins); EC 4.3.2.2 (Adenylosuccinate Lyase)
[Em] Mes de ingreso:1708
[Cu] Fecha actualización por clase:170803
[Lr] Fecha última revisión:170803
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170531
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M117.787994


  9 / 945961 MEDLINE  
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[PMID]:28557716
[Au] Autor:Naples J; Martin A; Sobelman D; Schoem S
[Ad] Dirección:Department of Otolaryngology, University of Connecticut Health Center, Farmington, Connecticut; jnaples513@gmail.com.
[Ti] Título:Unusual Fungal Lesion Presenting as a Neoplastic Pediatric Tongue Mass.
[So] Fuente:Pediatrics;139(5), 2017 May.
[Is] ISSN:1098-4275
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Tongue lesions in the pediatric population are rare. The differential diagnosis of these lesions is broad, and rapid growth of the lesion is concerning for a neoplastic process. We present a rare case of a fungal lesion mimicking a neoplastic growth in a 22-month-old girl. She underwent complete excision successfully. Full evaluation for benign and malignant neoplasms was negative. Tissue culture demonstrated growth of a rare C species to be the cause of the lesion. Postoperatively, she continues to do well, without regrowth 6 months later. This case reinforces the role of tissue culture when histology fails to demonstrate a diagnosis and emphasizes the need for efficient communication between the pediatrician, otolaryngologist, and pathologist for timely excision.
[Mh] Términos MeSH primario: Antifúngicos/uso terapéutico
Candida/aislamiento & purificación
Candidiasis/diagnóstico
Neoplasias de la Lengua/diagnóstico
Lengua/patología
[Mh] Términos MeSH secundario: Candidiasis/quimioterapia
Diagnóstico Diferencial
Femenino
Humanos
Lactante
Lengua/microbiología
[Pt] Tipo de publicación:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Antifungal Agents)
[Em] Mes de ingreso:1708
[Cu] Fecha actualización por clase:170803
[Lr] Fecha última revisión:170803
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:170530
[St] Status:MEDLINE


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[PMID]:28539362
[Au] Autor:Zachrdla M; Padrta P; Rabatinová A; Sanderová H; Barvík I; Krásný L; Zídek L
[Ad] Dirección:From the Central European Institute of Technology and.
[Ti] Título:Solution structure of domain 1.1 of the σ factor from is preformed for binding to the RNA polymerase core.
[So] Fuente:J Biol Chem;292(28):11610-11617, 2017 Jul 14.
[Is] ISSN:1083-351X
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Bacterial RNA polymerase (RNAP) requires σ factors to recognize promoter sequences. Domain 1.1 of primary σ factors (σ1.1) prevents their binding to promoter DNA in the absence of RNAP, and when in complex with RNAP, it occupies the DNA-binding channel of RNAP. Currently, two 3D structures of σ1.1 are available: from in complex with RNAP and from solved free in solution. However, these two structures significantly differ, and it is unclear whether this difference is due to an altered conformation upon RNAP binding or to differences in intrinsic properties between the proteins from these two distantly related species. Here, we report the solution structure of σ1.1 from the Gram-positive bacterium We found that σ1.1 is highly compact because of additional stabilization not present in σ1.1 from the other two species and that it is more similar to σ1.1. Moreover, modeling studies suggested that σ1.1 requires minimal conformational changes for accommodating RNAP in the DNA channel, whereas σ1.1 must be rearranged to fit therein. Thus, the mesophilic species and share the same σ1.1 fold, whereas the fold of σ1.1 from the thermophile is distinctly different. Finally, we describe an intriguing similarity between σ1.1 and δ, an RNAP-associated protein in , bearing implications for the so-far unknown binding site of δ on RNAP. In conclusion, our results shed light on the conformational changes of σ1.1 required for its accommodation within bacterial RNAP.
[Mh] Términos MeSH primario: Bacillus subtilis/metabolismo
Proteínas Bacterianas/metabolismo
ADN Bacteriano/metabolismo
ARN Polimerasas Dirigidas por ADN/metabolismo
Modelos Moleculares
Factor sigma/metabolismo
Thermotoga maritima/enzimología
[Mh] Términos MeSH secundario: Secuencia de Aminoácidos
Proteínas Bacterianas/química
Proteínas Bacterianas/genética
Sitios de Unión
Isótopos de Carbono
Secuencia Conservada
ADN Bacteriano/química
ARN Polimerasas Dirigidas por ADN/química
ARN Polimerasas Dirigidas por ADN/genética
Isótopos de Nitrógeno
Conformación de Ácido Nucleico
Fragmentos de Péptidos/química
Fragmentos de Péptidos/genética
Fragmentos de Péptidos/metabolismo
Conformación Proteica
Pliegue de Proteína
Dominios y Motivos de Interacción de Proteínas
Estabilidad Proteica
Subunidades de Proteína
Proteínas Recombinantes/química
Proteínas Recombinantes/metabolismo
Alineación de Secuencia
Factor sigma/química
Factor sigma/genética
Homología Estructural de Proteína
[Pt] Tipo de publicación:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Bacterial Proteins); 0 (Carbon Isotopes); 0 (DNA, Bacterial); 0 (Nitrogen Isotopes); 0 (Peptide Fragments); 0 (Protein Subunits); 0 (Recombinant Proteins); 0 (Sigma Factor); EC 2.7.7.6 (DNA-Directed RNA Polymerases)
[Em] Mes de ingreso:1708
[Cu] Fecha actualización por clase:170803
[Lr] Fecha última revisión:170803
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170525
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M117.784074



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