| [PMID]: | 23085697 |
| [Au] Autor: | Sotlar K; Valent P; Horny HP |
| [Ad] Dirección: | Pathologisches Institut, Ludwig-Maximilians-Universität München, Thalkirchner Str 36, 80337 München, Deutschland. |
| [Ti] Título: | [Mastocytosis and eosinophilic leukemia: diagnostics and classification]. |
| [Ti] Título: | Mastozytosen und myeloische Neoplasien mit Eosinophilie: Diagnostik und Klassifikation.. |
| [So] Fuente: | Pathologe;33(6):539-52, 2012 Nov. |
| [Is] ISSN: | 1432-1963 |
| [Cp] País de publicación: | Germany |
| [La] Idioma: | ger |
| [Ab] Resumen: | Mastocytosis and myeloid eosinophilic neoplasms are rare diseases of the bone marrow and are often a diagnostic challenge for hematopathologists. In mastocytosis, compact mast cell infiltrates represent the main diagnostic criterion and for myeloid eosinophilic neoplasms, eosinophilic granulocytes dominate the histological picture. Both disease groups include phenotypically and prognostically very different entities which are each defined by WHO criteria. For systemic mastocytosis (SM), a differentiation between indolent and aggressive or even leukemic forms is of prognostic importance. In indolent variants of SM, a local and/or systemic, usually reactive increase in eosinophilic granulocytes (SM-eo) is often observed. In contrast, an increase in neoplastic eosinophils is often observed in advanced SM, predominantly in diseases designated SM with associated non-mastocytic hematological neoplasms (SM-AHNMD), e.g. in SM with chronic eosinophilic leukemia (SM-CEL). Apart from mastocytoses, immunophenotypically aberrant tissue mast cells are only observed in certain rare forms of myeloid neoplasms with eosinophilia, in particular in myeloproliferative neoplasms (MPN-eo) with cytogenic anomalies in the platelet-derived growth factor receptor (PDGFR). The World Health Organization (WHO) classification of eosinophilic leukemias, however, fulfils the morphological and clinical requirements in a limited way only and needs an update. |
| [Mh] Términos MeSH primario: |
Síndrome Hipereosinofílico/clasificación Síndrome Hipereosinofílico/diagnóstico Mastocitosis Sistémica/clasificación Mastocitosis Sistémica/diagnóstico Mastocitosis/clasificación Mastocitosis/diagnóstico
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| [Mh] Términos MeSH secundario: |
Biopsia con Aguja Médula Ósea/patología Coristoma/patología Análisis Citogenético Diagnóstico Diferencial Eosinófilos/patología Síndrome Hipereosinofílico/genética Síndrome Hipereosinofílico/patología Inmunofenotipificación Leucemia de Mastocitos/clasificación Leucemia de Mastocitos/diagnóstico Leucemia de Mastocitos/genética Leucemia de Mastocitos/patología Mastocitos/patología Mastocitosis/genética Mastocitosis/patología Mastocitosis Sistémica/genética Mastocitosis Sistémica/patología Enfermedades Mielodisplásicas-Mieloproliferativas/clasificación Enfermedades Mielodisplásicas-Mieloproliferativas/diagnóstico Enfermedades Mielodisplásicas-Mieloproliferativas/genética Enfermedades Mielodisplásicas-Mieloproliferativas/patología Pronóstico Receptores del Factor de Crecimiento Derivado de Plaquetas/genética
|
| [Pt] Tipo de publicación: | ENGLISH ABSTRACT; JOURNAL ARTICLE |
[Nm] Nombre de substancia:
| EC 2.7.10.1 (Receptors, Platelet-Derived Growth Factor) |
| [Em] Mes de ingreso: | 1305 |
| [Sb] Subgrupo de revista: | IM |
| [Da] Fecha de ingreso para procesamiento: | 121022 |
| [St] Status: | MEDLINE |
| [do] DOI: | 10.1007/s00292-012-1654-0 |