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Búsqueda : Encefalitis and Transmitida and Por and Garrapatas [Palabras]
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  1 / 2705 MEDLINE  
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[PMID]:28453842
[Au] Autor:Lipowski D; Popiel M; Perlejewski K; Nakamura S; Bukowska-Osko I; Rzadkiewicz E; Dzieciatkowski T; Milecka A; Wenski W; Ciszek M; Debska-Slizien A; Ignacak E; Cortes KC; Pawelczyk A; Horban A; Radkowski M; Laskus T
[Ad] Dirección:Department of Infectious Diseases, Warsaw Medical University, Warsaw, Poland.
[Ti] Título:A Cluster of Fatal Tick-borne Encephalitis Virus Infection in Organ Transplant Setting.
[So] Fuente:J Infect Dis;215(6):896-901, 2017 03 15.
[Is] ISSN:1537-6613
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Background: Tick-borne encephalitis virus (TBEV) infection has become a major health problem in Europe and is currently a common cause of viral brain infection in many countries. Encephalitis in transplant recipients, althrough rare, is becoming a recognized complication. Our study provides the first description of transmission of TBEV through transplantation of solid organs. Methods: Three patients who received solid organ transplants from a single donor (2 received kidney, and 1 received liver) developed encephalitis 17-49 days after transplantation and subsequently died. Blood and autopsy tissue samples were tested by next-generation sequencing (NGS) and reverse transcription polymerase chain reaction (RT-PCR). Results: All 3 recipients were first analyzed in autopsy brain tissue samples and/or cerebrospinal fluid by NGS, which yielded 24-52 million sequences per sample and 9-988 matched TBEV sequences in each patient. The presence of TBEV was confirmed by RT-PCR in all recipients and in the donor, and direct sequencing of amplification products corroborated the presence of the same viral strain. Conclusions: We demonstrated transmission of TBEV by transplantation of solid organs. In such a setting, TBEV infection may be fatal, probably due to pharmacological immunosuppression. Organ donors should be screened for TBEV when coming from or visiting endemic areas.
[Mh] Términos MeSH primario: Encéfalo/virología
Virus de la Encefalitis Transmitidos por Garrapatas/aislamiento & purificación
Encefalitis Transmitida por Garrapatas/transmisión
Trasplante de Órganos/efectos adversos
Donantes de Tejidos
[Mh] Términos MeSH secundario: Adulto
Autopsia
Selección de Donante
Encefalitis Transmitida por Garrapatas/etiología
Resultado Fatal
Seres Humanos
Masculino
Mediana Edad
Polonia
Complicaciones Posoperatorias/etiología
ARN Viral/sangre
Análisis de Secuencia de ARN
[Pt] Tipo de publicación:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (RNA, Viral)
[Em] Mes de ingreso:1706
[Cu] Fecha actualización por clase:180308
[Lr] Fecha última revisión:180308
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix040


  2 / 2705 MEDLINE  
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[PMID]:28456648
[Au] Autor:Al-Tawfiq JA; Memish ZA
[Ad] Dirección:Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia; Indiana University School of Medicine, Indianapolis, IN 46202, USA.
[Ti] Título:Alkhurma hemorrhagic fever virus.
[So] Fuente:Microbes Infect;19(6):305-310, 2017 06.
[Is] ISSN:1769-714X
[Cp] País de publicación:France
[La] Idioma:eng
[Ab] Resumen:Alkhurma hemorrhagic fever virus (AHFV) was first isolated in Jeddah, Saudi Arabia, in the 1990s from the blood of a butcher. Subsequently, the virus was recognized in many patients in Saudi Arabia and rarely from Egypt and Djibouti. In this review, we summarize the current literature on AHFV globally with special focus on Saudi Arabia.
[Mh] Términos MeSH primario: Virus de la Encefalitis Transmitidos por Garrapatas/aislamiento & purificación
Encefalitis Transmitida por Garrapatas/transmisión
[Mh] Términos MeSH secundario: Animales
Modelos Animales de Enfermedad
Virus de la Encefalitis Transmitidos por Garrapatas/clasificación
Encefalitis Transmitida por Garrapatas/prevención & control
Seres Humanos
Arabia Saudita
Estaciones del Año
[Pt] Tipo de publicación:JOURNAL ARTICLE; REVIEW
[Em] Mes de ingreso:1801
[Cu] Fecha actualización por clase:180305
[Lr] Fecha última revisión:180305
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170501
[St] Status:MEDLINE


  3 / 2705 MEDLINE  
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[PMID]:27779467
[Au] Autor:Meltzer E; Paran Y; Lustig Y; Stienlauf S; Weinberger M; Schwartz E
[Ti] Título:Travel-Related Tick-Borne Encephalitis, Israel, 2006-2014.
[So] Fuente:Emerg Infect Dis;23(1):119-121, 2017 01.
[Is] ISSN:1080-6059
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:During 2006-2014, four tick-borne encephalitis (TBE) cases occurred among Israeli travelers. We calculated TBE incidence at 321.0, 45.0, 13.2, and 7.5 cases/100,000 travelers/year of travel to Sweden, Switzerland, Austria, and Germany, respectively. TBE incidence among travelers to these destinations appears to justify TBE vaccination in accordance with World Health Organization recommendations.
[Mh] Términos MeSH primario: Vectores Arácnidos/virología
Encefalitis Transmitida por Garrapatas/epidemiología
Encefalitis Transmitida por Garrapatas/transmisión
Garrapatas/virología
Viaje
[Mh] Términos MeSH secundario: Animales
Austria/epidemiología
Virus de la Encefalitis Transmitidos por Garrapatas/patogenicidad
Virus de la Encefalitis Transmitidos por Garrapatas/fisiología
Encefalitis Transmitida por Garrapatas/prevención & control
Alemania/epidemiología
Seres Humanos
Incidencia
Israel/epidemiología
Suecia/epidemiología
Suiza/epidemiología
Vacunación
Vacunas Virales/administración & dosificación
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Viral Vaccines)
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180209
[Lr] Fecha última revisión:180209
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:161026
[St] Status:MEDLINE
[do] DOI:10.3201/eid2301.160888


  4 / 2705 MEDLINE  
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[PMID]:29323856
[Au] Autor:Mel'nikova OV; Adel'shin RV; Korzun VM; Trushina YN; Andaev EI
[Ti] Título:Tick-borne encephalitis virus isolates from natural foci of the Irkutsk region: clarification of the genotype landscape.
[So] Fuente:Vopr Virusol;61(5):229-34, 2016.
[Is] ISSN:0507-4088
[Cp] País de publicación:Russia (Federation)
[La] Idioma:eng
[Ab] Resumen:The Irkutsk region is the unique territory where all known subtypes of tick-borne encephalitis virus (TBEV) circulate. In the last years, the phenomenon of changes in TBEV subtypes (substitution of the Far-Eastern subtype by the Siberian one) was noted in some regions of the Russian Federation. The results of individual investigation of 11522 Ixodes persulcatus ticks and brain specimens from 81 small mammals collected in natural foci of the Irkutsk region during 2006-2014 are presented in the article. More than 60 TBEV strains have been isolated and studied by virological methods; E gene fragments (1193 b.p.) of 68 isolates have been typed. The majority of the strains (irrespective of subtype) were of high virulence for laboratory mice (LM) in case of both intracerebral and subcutaneous inoculation of virus. All isolates from warm-blooded small mammals and humans were of high virulence for LM, but placed in the same clusters of the phylogenetic tree with ticks collected in the same area. Tick-borne strains of different virulence also did not form separate clusters on the tree. Phylogenetic analysis showed that modern TBEV genotypic landscape of the studied territory is changing toward absolute predominance of the Siberian subtype (94.1%). This subtype is represented by two groups with prototype strains "Zausaev" and "Vasilchenko". The "Vasilchenko" group of strains is spread on the whole territory under study; the strains of "Zausaev" group were isolated previously in the Irkutsk suburbs. The European subtype of TBEV circulates in natural foci of Pribaikalie permanently (at least 5% of the random sampling); the strains are of high virulence for LM. The Far-Eastern TBEV subtype was not found within the group of isolates collected in 20062014. The phylogenetic relationship of the strains under study had a higher correlation with the place of isolation than with the year or source.
[Mh] Términos MeSH primario: Virus de la Encefalitis Transmitidos por Garrapatas/genética
Encefalitis Transmitida por Garrapatas/epidemiología
Encefalitis Transmitida por Garrapatas/veterinaria
Genoma Viral
Genotipo
Ixodes/virología
[Mh] Términos MeSH secundario: Animales
Vectores de Enfermedades
Virus de la Encefalitis Transmitidos por Garrapatas/clasificación
Virus de la Encefalitis Transmitidos por Garrapatas/aislamiento & purificación
Encefalitis Transmitida por Garrapatas/transmisión
Encefalitis Transmitida por Garrapatas/virología
Femenino
Seres Humanos
Mamíferos/virología
Ratones
Filogenia
Siberia/epidemiología
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180208
[Lr] Fecha última revisión:180208
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180112
[St] Status:MEDLINE


  5 / 2705 MEDLINE  
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[PMID]:29323844
[Au] Autor:Pukhovskaya NM; Morozova OV; Belozerova NB; Bakhmetyeva SV; Vysochina NP; Zdanovskaya NI; Ivanov LI
[Ti] Título:Comparative analysis of genomes of tick-borne encephalitis virus strains isolated from mosquitoes and ticks.
[So] Fuente:Vopr Virusol;62(1):30-5, 2017.
[Is] ISSN:0507-4088
[Cp] País de publicación:Russia (Federation)
[La] Idioma:eng
[Ab] Resumen:The tick-borne encephalitis virus (TBEV) strain Lazo MP36 was isolated from the pool of mosquitoes Aedes vexans collected in Lazo region of Khabarovsk territory in August 2014. Phylogenetic analysis of the strain Lazo MP36 complete genome (GenBank accession number KT001073) revealed its correspondence to the TBEV Far Eastern subtype and differences from the following strains: 1) from ticks Ixodes persulcatus P. Schulze, 1930 [vaccine strain 205 (JX498939) and strains Khekhtzir 1230 (KF880805), Chichagovka (KP844724), Birobidzhan 1354 (KF880805) isolated in 2012-2013]; 2) from mosquitoes [strain Malyshevo (KJ744034) isolated in 1978 from Aedes vexans nipponii in Khabarovsk territory; strain Sakhalin 6-11 isolated from the pool of mosquitoes in 2011 (KF826916)]; 3) from human brain [vaccine strain Sofjin (JN229223), Glubinnoe/2004(DQ862460). Kavalerovo (DQ862460), Svetlogorie (DQ862460)]. The fusion peptide necessary for flavivirus entry to cells of the three TBEV strains isolated from mosquitoes (Lazo MP36, Malyshevo and Sakhalin 6-11) has the canonical structure 98-DRGWGNHCGLFGKGSI-113 for the tick-borne flaviviruses. Amino acid transition H104G typical for the mosquito-borne flaviviruses was not found. Structures of 5'- and 3'-untranslated (UTR) regions of the TBEV strains from mosquitoes were 85-98% homologous to the TBEV strains of all subtypes without recombination with mosquito-borne flaviviruses found in the Far East of Russia. Secondary structures of 5'- and 3'-UTR as well as cyclization sequences (CS) of types a and B are highly homologous for all TBEV isolates independently of the biological hosts and vectors. similarity of the genomes of the TBEV isolates from mosquitoes, ticks and patients as well as pathogenicity of the isolates for new-borne laboratory mice and tissue cultures might suggest a possible role of mosquitoes in the TBEV circulation in natural foci as an accidental or additional virus carrier.
[Mh] Términos MeSH primario: Aedes/virología
Virus de la Encefalitis Transmitidos por Garrapatas/genética
Encefalitis Transmitida por Garrapatas/epidemiología
Genoma Viral
Ixodes/virología
ARN Viral/genética
[Mh] Términos MeSH secundario: Secuencia de Aminoácidos
Animales
Animales Recién Nacidos
Vectores de Enfermedades
Perros
Virus de la Encefalitis Transmitidos por Garrapatas/clasificación
Virus de la Encefalitis Transmitidos por Garrapatas/aislamiento & purificación
Encefalitis Transmitida por Garrapatas/transmisión
Encefalitis Transmitida por Garrapatas/virología
Lejano Oriente/epidemiología
Genotipo
Seres Humanos
Ratones
Ratones Consanguíneos ICR
Conformación de Ácido Nucleico
Filogenia
ARN Viral/química
ARN Viral/aislamiento & purificación
Roedores/virología
Alineación de Secuencia
Homología de Secuencia de Aminoácido
Siberia/epidemiología
[Pt] Tipo de publicación:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (RNA, Viral)
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180208
[Lr] Fecha última revisión:180208
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180112
[St] Status:MEDLINE


  6 / 2705 MEDLINE  
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[PMID]:29368829
[Au] Autor:Barkhash AV; Babenko VN; Voevoda MI; Romaschenko AG
[Ti] Título:[Polymorphism of CD209 and TLR3 genes in populations of North Eurasia].
[So] Fuente:Genetika;52(6):697-704, 2016 Jun.
[Is] ISSN:0016-6758
[Cp] País de publicación:Russia (Federation)
[La] Idioma:rus
[Ab] Resumen:The DC-SIGN (dendritic cell-specific intercellular adhesion molecule (ICAM)-3-grabbing non-integrin) and TLR3 (toll-like receptor 3) proteins are key effectors of the innate immunity and particularly play an important role in the organism's antiviral defense as pattern-recognition receptors. Previously, we demonstrated that certain genotypes and alleles of single nucleotide polymorphisms (SNPs) rs2287886 (G/A) in the promoter region of the CD209 gene (encoding DC-SIGN) and rs3775291 (G/A, Leu412Phe) in the exon 4 of the TLR3 gene are associated with human predisposition to tick-borne encephalitis in the Russian population. In the present work, the distribution of genotype and allele frequencies for these SNPs was studied in seven populations of North Eurasia, including Caucasians (Russians and Germans (from Altai region)), Central Asian Mongoloids (Altaians, Khakass, Tuvinians, and Shorians), and Arctic Mongoloids (Chukchi). It was found that the CD209 gene rs2287886 SNP A/A genotype and A allele, as well as the TLR3 gene rs3775291 SNP G/G genotype and G allele (the frequencies of which in our previous studies were increased in tick-borne encephalitis patients as compared with the population control (Russian citizens of Novosibirsk)), are preserved with a high frequency in Central Asian Mongoloids (who for a long time regularly came in contact with tick-borne encephalitis virus in places of their habitation). We suggested that predisposition to tick-borne encephalitis in Central Asian Mongoloid populations can be predetermined by a different set of genes and their polymorphisms than in the Russian population.
[Mh] Términos MeSH primario: Alelos
Moléculas de Adhesión Celular/genética
Genotipo
Lectinas Tipo C/genética
Polimorfismo de Nucleótido Simple
Receptores de Superficie Celular/genética
Receptor Toll-Like 3/genética
[Mh] Términos MeSH secundario: Encefalitis Transmitida por Garrapatas/genética
Femenino
Seres Humanos
Masculino
Siberia/etnología
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Cell Adhesion Molecules); 0 (DC-specific ICAM-3 grabbing nonintegrin); 0 (Lectins, C-Type); 0 (Receptors, Cell Surface); 0 (TLR3 protein, human); 0 (Toll-Like Receptor 3)
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180205
[Lr] Fecha última revisión:180205
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180126
[St] Status:MEDLINE


  7 / 2705 MEDLINE  
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[PMID]:27772539
[Au] Autor:Zeman P
[Ad] Dirección:Medical Laboratories,Prague,Czech Republic.
[Ti] Título:Cyclic patterns in the central European tick-borne encephalitis incidence series.
[So] Fuente:Epidemiol Infect;145(2):358-367, 2017 01.
[Is] ISSN:1469-4409
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Tick-borne encephalitis (TBE) is peculiar due to its unstable dynamics with profound inter-annual fluctuations in case numbers - a phenomenon not well understood to date. Possible reasons - apart from variable human contact with TBE foci - include external factors, e.g. climatic forcing, autonomous oscillations of the disease system itself, or a combined action of both. Spectral analysis of TBE data from six regions of central Europe (CE) revealed that the ostensibly chaotic dynamics can be explained in terms of four superposed (quasi-)periodical oscillations: a quasi-biennial, triennial, pentennial, and a decadal cycle. These oscillations exhibit a high degree of regularity and synchrony across CE. Nevertheless, some amplitude and phase variations are responsible for regional differences in incidence patterns. In addition, periodic changes occur in the degree of synchrony in the regions: marked in-phase periods alternate with rather off-phase periods. Such a feature in the disease dynamics implies that it arises as basically diverging self-oscillations of local disease systems which, at intervals, receive synchronizing impulses, such as periodic variations in food availability for key hosts driven by external factors. This makes the disease dynamics synchronized over a large area during peaks in the synchronization signal, shifting to asynchrony in the time in between.
[Mh] Términos MeSH primario: Encefalitis Transmitida por Garrapatas/epidemiología
Garrapatas/crecimiento & desarrollo
[Mh] Términos MeSH secundario: Animales
Femenino
Seres Humanos
Incidencia
Masculino
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1706
[Cu] Fecha actualización por clase:171125
[Lr] Fecha última revisión:171125
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:161025
[St] Status:MEDLINE


  8 / 2705 MEDLINE  
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[PMID]:28791941
[Au] Autor:Zeman P
[Ad] Dirección:Medical Laboratories,Prague,Czech Republic.
[Ti] Título:Predictability of tick-borne encephalitis fluctuations.
[So] Fuente:Epidemiol Infect;145(13):2781-2786, 2017 10.
[Is] ISSN:1469-4409
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Tick-borne encephalitis is a serious arboviral infection with unstable dynamics and profound inter-annual fluctuations in case numbers. A dependable predictive model has been sought since the discovery of the disease. The present study demonstrates that four superimposed cycles, approximately 2·4, 3, 5·4, and 10·4 years long, can account for three-fifths of the variation in the disease fluctuations over central Europe. Using harmonic regression, these cycles can be projected into the future, yielding forecasts of sufficient accuracy for up to 4 years ahead. For the years 2016-2018, this model predicts elevated incidence levels in most parts of the region.
[Mh] Términos MeSH primario: Encefalitis Transmitida por Garrapatas/epidemiología
[Mh] Términos MeSH secundario: Encefalitis Transmitida por Garrapatas/virología
Europa (Continente)/epidemiología
Seres Humanos
Incidencia
Modelos Teóricos
Periodicidad
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1709
[Cu] Fecha actualización por clase:171125
[Lr] Fecha última revisión:171125
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170810
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268817001662


  9 / 2705 MEDLINE  
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[PMID]:28791846
[Au] Autor:Kepka A; Janas RM; Pancewicz SA; Swierzbinska R
[Ad] Dirección:Department of Biochemistry, Radioimmunology and Experimental Medicine, the Children's Memorial Health Institute, Warszawa, Poland.
[Ti] Título:Serum carnitine and acyl-carnitine in patients with meningitis due to tick-borne encephalitis virus infection.
[So] Fuente:Adv Clin Exp Med;26(2):277-280, 2017 Mar-Apr.
[Is] ISSN:1899-5276
[Cp] País de publicación:Poland
[La] Idioma:eng
[Ab] Resumen:BACKGROUND: Hard ticks are the main vectors of tick-borne encephalitis virus (TBEV). Free carnitine (FC) and acylcarnitines (AC) have the basic role in ß-oxidation as well as the modulation of immune and nervous system. Homeostasis of carnitines in the TBE patients was not studied so far. OBJECTIVES: This study aimed to evaluate FC and AC serum concentrations in patients with meningitis due to TBEV infection before and after 14 ± 3 days of treatment. MATERIAL AND METHODS: The study was performed in 14 patients aged 48 ± 29 years that were divided a posteriori (based on their FC level before and after treatment) into 2 subgroups: 1-8 and 9-14. Diagnosis was based on the neurological, serological and pleocytosis evaluation. RESULTS: The FC level in patients 1-8 before treatment (24.1 ± 8.1) was significantly lower than in patients post-treatment (34.4 ± 8.3), lower than in the control group (40.5 ± 7.6), and lower than in patients 9-14 before treatment (40.0 ± 13.5) but not lower than in the patients 9-14 after treatment (24.7 ± 7.3 µmol/L), respectively, p < 0.05. AC concentration in the patients 1-8 before treatment (4.7 ± 2.2) was apparently lower than in patients post-treatment (9.5 ± 3.9 µmol/L) but the values were not significantly different. In patients 9-14 before treatment the AC concentration (16.3 ± 12.6) was higher than in patients after treatment (5.3 ± 4.0 µmol/L), but the difference was not statistically significant. CONCLUSIONS: FC and AC homeostasis in circulation was disturbed in the patients with meningitis due to TBEV infection patients. The mean levels of FC and AC in 60% of the patients were below the normal range but normalized after treatment whereas in 40% of the patients they were near or at a normal range and significantly decreased after treatment. Explanation of this intriguing finding and its clinical significance is not easy without further studies.
[Mh] Términos MeSH primario: Carnitina/análogos & derivados
Carnitina/sangre
Virus de la Encefalitis Transmitidos por Garrapatas/aislamiento & purificación
Encefalitis Transmitida por Garrapatas/sangre
Meningitis/sangre
[Mh] Términos MeSH secundario: Adulto
Anciano
Animales
Anticuerpos Antivirales/sangre
Anticuerpos Antivirales/inmunología
Virus de la Encefalitis Transmitidos por Garrapatas/inmunología
Virus de la Encefalitis Transmitidos por Garrapatas/fisiología
Encefalitis Transmitida por Garrapatas/complicaciones
Encefalitis Transmitida por Garrapatas/virología
Femenino
Seres Humanos
Inmunoglobulina G/sangre
Inmunoglobulina G/inmunología
Inmunoglobulina M/sangre
Inmunoglobulina M/inmunología
Masculino
Meningitis/complicaciones
Meningitis/terapia
Mediana Edad
Resultado del Tratamiento
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nombre de substancia:
0 (Antibodies, Viral); 0 (Immunoglobulin G); 0 (Immunoglobulin M); 0 (acylcarnitine); S7UI8SM58A (Carnitine)
[Em] Mes de ingreso:1709
[Cu] Fecha actualización por clase:170908
[Lr] Fecha última revisión:170908
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170810
[St] Status:MEDLINE
[do] DOI:10.17219/acem/63006


  10 / 2705 MEDLINE  
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[PMID]:28786780
[Au] Autor:Selinger M; Wilkie GS; Tong L; Gu Q; Schnettler E; Grubhoffer L; Kohl A
[Ad] Dirección:1​Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, Branisovská 31, 370 05 Ceské Budejovice, Czech Republic 2​Faculty of Science, University of South Bohemia in Ceské Budejovice, Branisovská 31, 370 05 Ceské Budejovice, Czech Republic.
[Ti] Título:Analysis of tick-borne encephalitis virus-induced host responses in human cells of neuronal origin and interferon-mediated protection.
[So] Fuente:J Gen Virol;98(8):2043-2060, 2017 Aug.
[Is] ISSN:1465-2099
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Tick-borne encephalitis virus (TBEV) is a member of the genus Flavivirus. It can cause serious infections in humans that may result in encephalitis/meningoencephalitis. Although several studies have described the involvement of specific genes in the host response to TBEV infection in the central nervous system (CNS), the overall network remains poorly characterized. Therefore, we investigated the response of DAOY cells (human medulloblastoma cells derived from cerebellar neurons) to TBEV (Neudoerfl strain, Western subtype) infection to characterize differentially expressed genes by transcriptome analysis. Our results revealed a wide panel of interferon-stimulated genes (ISGs) and pro-inflammatory cytokines, including type III but not type I (or II) interferons (IFNs), which are activated upon TBEV infection, as well as a number of non-coding RNAs, including long non-coding RNAs. To obtain a broader view of the pathways responsible for eliciting an antiviral state in DAOY cells we examined the effect of type I and III IFNs and found that only type I IFN pre-treatment inhibited TBEV production. The cellular response to TBEV showed only partial overlap with gene expression changes induced by IFN-ß treatment - suggesting a virus-specific signature - and we identified a group of ISGs that were highly up-regulated following IFN-ß treatment. Moreover, a high rate of down-regulation was observed for a wide panel of pro-inflammatory cytokines upon IFN-ß treatment. These data can serve as the basis for further studies of host-TBEV interactions and the identification of ISGs and/or lncRNAs with potent antiviral effects in cases of TBEV infection in human neuronal cells.
[Mh] Términos MeSH primario: Citocinas/genética
Virus de la Encefalitis Transmitidos por Garrapatas/fisiología
Encefalitis Transmitida por Garrapatas/genética
Encefalitis Transmitida por Garrapatas/virología
Interferones/genética
[Mh] Términos MeSH secundario: Citocinas/inmunología
Virus de la Encefalitis Transmitidos por Garrapatas/genética
Encefalitis Transmitida por Garrapatas/inmunología
Interacciones Huésped-Patógeno
Seres Humanos
Interferones/inmunología
Neuronas/inmunología
Neuronas/virología
Activación Transcripcional
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Cytokines); 9008-11-1 (Interferons)
[Em] Mes de ingreso:1709
[Cu] Fecha actualización por clase:170906
[Lr] Fecha última revisión:170906
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170809
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000853



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