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[PMID]: 23451739 [Au] Autor: Sanders M; Lester S [Ti] Título: Paget disease of the breast with invasion from nipple skin into the dermis. [So] Fuente: Arch Pathol Lab Med;137(3):307, 2013 Mar. [Is] ISSN: 1543-2165 [Cp] País de publicación: United States [La] Idioma: eng [Mh] Términos MeSH primario: Neoplasias de la Mama/patología Dermis/patología Pezones/patología Enfermedad de Paget Mamaria/patología [Mh] Términos MeSH secundario: Femenino Humanos Invasividad Neoplásica [Pt] Tipo de publicación: LETTER [Em] Mes de ingreso: 1304 [Sb] Subgrupo de revista: AIM; IM [Da] Fecha de ingreso para procesamiento: 130304 [St] Status: MEDLINE [do] DOI: 10.5858/arpa.2012-0683-LE

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[PMID]: 21548119 [Au] Autor: Vohra P; Ljung BM; Miller TR; Hwang ES; van Zante A [Ad] Dirección: Department of Pathology, University of California, San Francisco, California 94143-1785, USA. [Ti] Título: Paget's disease of the breast masquerading as squamous cell carcinoma on cytology: a case report. [So] Fuente: Diagn Cytopathol;40(11):1015-8, 2012 Nov. [Is] ISSN: 1097-0339 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: Paget's disease is an uncommon manifestation of breast carcinoma occurring in 1-2% of female patients with breast cancer. Here, we present a case of Paget's disease of the breast, which was initially interpreted as squamous cell carcinoma on cytology. This case report raises two issues. First, histological and cytological specimens of Paget's disease show a mixed population of epithelial cells including squamous cells with reactive changes and malignant glandular cells. In the current case, a mixed population of atypical keratinizing and nonkeratinizing epithelial cells was initially interpreted as squamous cell carcinoma of cutaneous origin. The marked reactive changes in the squamous epithelium involved by Paget's disease should be recognized. Second, this case is an unusual clinical presentation for Paget's disease of the breast as the nipple-areolar complex and underlying breast tissue were surgically absent at the time of diagnosis. Clinical suspicion, along with an awareness of the cytologic features and clinical presentation of Paget's disease, can help in reaching the correct diagnosis in a timely fashion. [Mh] Términos MeSH primario: Carcinoma de Células Escamosas/patología Inmunohistoquímica/métodos Enfermedad de Paget Mamaria/diagnóstico [Mh] Términos MeSH secundario: Biopsia con Aguja Fina Mama/patología Neoplasias de la Mama/patología Núcleo Celular/patología Tamaño de la Célula Citoplasma/patología Errores Diagnósticos Epitelio/patología Femenino Humanos Mediana Edad [Pt] Tipo de publicación: CASE REPORTS; JOURNAL ARTICLE [Em] Mes de ingreso: 1303 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 121022 [St] Status: MEDLINE [do] DOI: 10.1002/dc.21712

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[PMID]: 22883678 [Au] Autor: Ge HJ; Yang WT [Ti] Título: [Tumor and tumor-like lesion of nipple]. [So] Fuente: Zhonghua Bing Li Xue Za Zhi;41(5):347-50, 2012 May. [Is] ISSN: 0529-5807 [Cp] País de publicación: China [La] Idioma: chi [Mh] Términos MeSH primario: Absceso/patología Adenoma de las Glándulas Sudoríparas/patología Adenoma/patología Enfermedades de la Mama/patología Neoplasias de la Mama/patología Fístula/patología Pezones/patología Enfermedad de Paget Mamaria/patología Neoplasias de las Glándulas Sudoríparas/patología [Mh] Términos MeSH secundario: Adenoma/metabolismo Adenoma de las Glándulas Sudoríparas/metabolismo Marcadores Biológicos/metabolismo Neoplasias de la Mama/metabolismo Femenino Humanos Queratina-7/metabolismo Queratinas/metabolismo Mucina-1/metabolismo Enfermedad de Paget Mamaria/metabolismo Receptor erbB-2/metabolismo Neoplasias de las Glándulas Sudoríparas/metabolismo [Pt] Tipo de publicación: JOURNAL ARTICLE [Nm] Nombre de substancia: 0 (Biological Markers); 0 (CAM 5.2 antigen); 0 (Keratin-7); 0 (Mucin-1); 68238-35-7 (Keratins); EC 2.7.10.1 (Receptor, erbB-2) [Em] Mes de ingreso: 1303 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 120813 [St] Status: MEDLINE [do] DOI: 10.3760/cma.j.issn.0529-5807.2012.05.015

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[PMID]: 23276177 [Au] Autor: Sanders MA; Dominici L; Denison C; Golshan M; Wiecorek T; Lester SC [Ad] Dirección: Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, Kentucky, USA. [Ti] Título: Paget disease of the breast with invasion from nipple skin into the dermis: an unusual type of skin invasion not associated with an adverse outcome. [So] Fuente: Arch Pathol Lab Med;137(1):72-6, 2013 Jan. [Is] ISSN: 1543-2165 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: CONTEXT: Paget disease is an uncommon skin manifestation of breast cancer, associated with either invasive carcinoma or ductal carcinoma in situ in the underlying breast. In very rare cases, tumor cells within the epidermis invade through the basement membrane of the skin into the dermis. OBJECTIVES: To identify a series of cases of Paget disease with direct dermal invasion and to investigate the clinicopathologic features and outcome. DESIGN: Cases were identified during a 6-year period from the files of 2 hospitals. The clinical histories, imaging studies, and pathology reports were reviewed. RESULTS: Seven patients were identified, 5 with microinvasion (<0.1 cm) and 2 with 0.2- or 0.3-cm invasive carcinomas in the dermis. No lymphovascular invasion was seen. Sentinel nodes were negative in 3 patients who underwent biopsy. Five patients were treated with breast conservation with radiation. Three patients were at high risk for breast cancer because of prior breast cancer, Li-Fraumeni syndrome, or radiation for Hodgkin disease. The latter 2 patients underwent bilateral mastectomies. Three patients received hormonal therapy and 1 oophorectomy. No patient received chemotherapy. At follow-ups ranging from 4 to 66 months (median, 20 months), there have been no recurrences. CONCLUSIONS: Patients with direct dermal invasion from Paget disease had a favorable outcome during the available follow-up period. This type of dermal involvement must be distinguished from locally advanced invasive carcinomas with skin invasion classified as T4b in the American Joint Cancer Commission staging system, as cancers with other types of skin invasion are associated with a poor prognosis. [Mh] Términos MeSH primario: Neoplasias de la Mama/patología Enfermedad de Paget Mamaria/patología [Mh] Términos MeSH secundario: Adulto Anciano Neoplasias de la Mama/terapia Neoplasias de la Mama Masculina/patología Neoplasias de la Mama Masculina/terapia Dermis/patología Femenino Humanos Masculino Mediana Edad Invasividad Neoplásica/patología Estadificación de Neoplasias Pezones/patología Enfermedad de Paget Mamaria/terapia Pronóstico Piel/patología [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1302 [Sb] Subgrupo de revista: AIM; IM [Da] Fecha de ingreso para procesamiento: 130101 [St] Status: MEDLINE [do] DOI: 10.5858/arpa.2011-0611-OA

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[PMID]: 22920370 [Au] Autor: Psoma E; Nikolaidou O; Stavrogianni T; Mavromati A; Lytras K; Xirou P; Koumbanaki M; Panagiotopoulou D [Ad] Dirección: Radiology Department, Anticancer Hospital Theagenion of Thessaloniki, Thessaloniki, Greece. [Ti] Título: A rare case report of a primary large-cell neuroendocrine carcinoma of the breast with coexisting Paget disease. [So] Fuente: Clin Imaging;36(5):599-601, 2012 Sep-Oct. [Is] ISSN: 1873-4499 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: Neuroendocrine carcinomas are malignancies deriving from neuroendocrine cells existing in various sites of the body, most commonly in the lungs and gastrointestinal tract. Primary neuroendocrine carcinomas of the breast are extremely rare, and their diagnosis is confirmed by positive neuroendocrine markers. We describe a case of a 46-year-old woman with a palpable mass in her left breast for the previous 3 months. The tumor was resected and a primary large-cell neuroendocrine tumor of the breast was confirmed by histopathologic examination. Paget disease of the nipple was noted as well. [Mh] Términos MeSH primario: Neoplasias de la Mama/diagnóstico Carcinoma de Células Grandes/diagnóstico Carcinoma Neuroendocrino/diagnóstico Enfermedad de Paget Mamaria/diagnóstico [Mh] Términos MeSH secundario: Neoplasias de la Mama/patología Neoplasias de la Mama/terapia Carcinoma de Células Grandes/patología Carcinoma de Células Grandes/terapia Carcinoma Neuroendocrino/patología Carcinoma Neuroendocrino/terapia Terapia Combinada Diagnóstico Diferencial Femenino Humanos Mamografía Mediana Edad Enfermedad de Paget Mamaria/patología Enfermedad de Paget Mamaria/terapia Tomografía Computarizada por Rayos X Ultrasonografía Mamaria [Pt] Tipo de publicación: CASE REPORTS; JOURNAL ARTICLE [Em] Mes de ingreso: 1302 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 120827 [St] Status: MEDLINE [do] DOI: 10.1016/j.clinimag.2011.10.004

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[PMID]: 22381610 [Au] Autor: Bordes J; Cotte J; Prunet B; d'Aranda E; Meaudre E; Kaiser E [Ti] Título: Fatal right heart failure complicating undiagnosed metastatic breast cancer. [So] Fuente: J Emerg Med;43(1):e63-4, 2012 Jul. [Is] ISSN: 0736-4679 [Cp] País de publicación: United States [La] Idioma: eng [Mh] Términos MeSH primario: Neoplasias de la Mama/complicaciones Neoplasias de la Mama/diagnóstico Carcinoma Ductal de Mama/complicaciones Insuficiencia Cardíaca/complicaciones Enfermedad de Paget Mamaria/complicaciones [Mh] Términos MeSH secundario: Adulto Neoplasias de la Mama/patología Carcinoma Ductal de Mama/diagnóstico Carcinoma Ductal de Mama/secundario Resultado Fatal Femenino Humanos Enfermedad de Paget Mamaria/diagnóstico [Pt] Tipo de publicación: CASE REPORTS; LETTER [Em] Mes de ingreso: 1301 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 120716 [St] Status: MEDLINE [do] DOI: 10.1016/j.jemermed.2011.07.037

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[PMID]: 22901142 [Au] Autor: Zheng S; Song QK; Zhao L; Huang R; Sun L; Li J; Fan JH; Zhang BN; Yang HJ; Xu F; Zhang B; Qiao YL [Ad] Dirección: Department of Pathology, Center of Breast Disease, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. [Ti] Título: Characteristics of mammary Paget's disease in China: a national-wide multicenter retrospective study during 1999-2008. [So] Fuente: Asian Pac J Cancer Prev;13(5):1887-93, 2012. [Is] ISSN: 1513-7368 [Cp] País de publicación: Thailand [La] Idioma: eng [Ab] Resumen: The aim of this study was to detail characteristics of mammary Paget's disease (PD) representing the whole population in China. A total of 4211 female breast cancer inpatients at seven tertiary hospitals from seven representative geographical regions of China were collected randomly during 1999 to 2008. Data for demography, risk factors, diagnostic imaging test, physical examination and pathologic characters were surveyed and biomarker status was tested by immunohistochemistry. The differences of demography and risk factors between PD with breast cancer and other lesions were compared using Chi-square test or t-test, with attention to physical examination and pathological characters. The percentage of PD was 1.6% (68/4211) in all breast cancers. The mean age at diagnosis was 48.1, and 63.2% (43/68) patients were premenopausal. There is no difference in demography and risk factors between PD with breast cancer and other breast cancer (P>0.05). The main pattern of PD in physical exam and pathologic pattern were patients presenting with a palpable mass in breast (65/68, 95.6%) and PD with underlying invasive cancer (82.4%, 56/68) respectively. The rate of multifocal disease was 7.4% (5/68). PD with invasive breast cancer showed larger tumor size, more multifocal disease, lower ER and PR expression and higher HER2 overexpression than those in other invasive breast cancer (P<0.05). These results suggested that PD in China is a concomitant disease of breast cancer, and that PD with underlying invasive cancer has more multiple foci and more aggressive behavior compared with other breast invasive cancer. We address the urgent needs for establishing diagnostic and therapeutic guidelines for mammary PD in China. [Mh] Términos MeSH primario: Neoplasias de la Mama/patología Carcinoma Intraductal no Infiltrante/patología Enfermedad de Paget Mamaria/patología Lesiones Precancerosas/patología [Mh] Términos MeSH secundario: Anciano China Femenino Humanos Metástasis Linfática Masculino Mediana Edad Invasividad Neoplásica Estadificación de Neoplasias Pronóstico Estudios Retrospectivos Centros de Atención Terciaria Factores de Tiempo [Pt] Tipo de publicación: JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mes de ingreso: 1301 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 120820 [St] Status: MEDLINE

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[PMID]: 19821109 [Au] Autor: Song Y; Wang Z; Xu H; Yue Z; Xing C [Ad] Dirección: Department of Surgical Oncology and General Surgery, the First Hospital of China Medical University, Shenyang, 110001, China. songyongxi840309@126.com [Ti] Título: Paget's disease is associated with eleven cancerous regions: a case report and therapeutic strategy. [So] Fuente: J Huazhong Univ Sci Technolog Med Sci;29(5):677-8, 2009 Oct. [Is] ISSN: 1672-0733 [Cp] País de publicación: China [La] Idioma: eng [Ab] Resumen: Paget's disease of the breast is an uncommon disorder that accounts for 1% to 3% of all mammary tumors. The incidence of underlying carcinoma associated with Paget's disease has been reported in 82% to 100% of cases. The finding of underlying carcinoma reaches almost 100% when a palpable lump is also present. In this rare case, we described a patient presenting with Paget's disease but no palpable lump. However, we found 11 independent regions which were all invasive ductal carcinoma after the operation. Considering this patient, we should pay more attention to a multifocal and multicentric breast carcinoma associated with Paget's disease. Furthermore, we believe the mammography examination and a modified radical mastectomy are the most appropriate treatments for this population in clinical practice. [Mh] Términos MeSH primario: Neoplasias de la Mama/patología Carcinoma Ductal de Mama/patología Neoplasias Primarias Múltiples Enfermedad de Paget Mamaria/patología [Mh] Términos MeSH secundario: Neoplasias de la Mama/cirugía Carcinoma in Situ/patología Carcinoma in Situ/cirugía Carcinoma Ductal de Mama/cirugía Femenino Humanos Mamografía Mastectomía Mediana Edad Neoplasias Primarias Múltiples/patología Enfermedad de Paget Mamaria/cirugía [Pt] Tipo de publicación: CASE REPORTS; JOURNAL ARTICLE [Em] Mes de ingreso: 1301 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 091012 [St] Status: MEDLINE [do] DOI: 10.1007/s11596-009-0529-y

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[PMID]: 22786991 [Au] Autor: Ferris-James DM; Iuanow E; Mehta TS; Shaheen RM; Slanetz PJ [Ad] Dirección: Department of Radiology, Division of Breast Imaging, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA. dianamjames@gmail.com [Ti] Título: Imaging approaches to diagnosis and management of common ductal abnormalities. [So] Fuente: Radiographics;32(4):1009-30, 2012 Jul-Aug. [Is] ISSN: 1527-1323 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: Ductal disease is an important, often overlooked, and poorly understood issue in breast imaging that results in delays in diagnosis and patient care. The differential diagnosis for an intraductal mass is broad and includes inspissated secretions, infection, hemorrhage, solitary or multiple papillomas, and malignancy. Each breast is composed of eight or more ductal systems, with most disease arising in the terminal ductal-lobular unit. Imaging evaluation of the ductal system usually entails a combination of mammography, galactography, ultrasonography (US), and in some cases magnetic resonance (MR) imaging. The most common finding with all modalities is ductal dilatation with a focal or diffuse abnormality. Benign diseases of the ducts include duct ectasia, blocked ducts, inflammatory infiltrates, periductal mastitis, apocrine metaplasia, intraductal papillomas, and papillomatosis. Malignant diseases of the ducts include ductal carcinoma in situ, invasive ductal carcinoma, and Paget disease. Most commonly performed with US or MR imaging guidance, percutaneous biopsy methods are helpful in diagnosis and management of ductal findings. Because most findings are smaller than 1 cm, located within a duct, and thus sometimes not visible after a single pass, vacuum-assisted devices help improve the accuracy of sampling. [Mh] Términos MeSH primario: Enfermedades de la Mama/diagnóstico Enfermedades de la Mama/terapia Imagen por Resonancia Magnética/métodos Glándulas Mamarias Humanas/patología Ultrasonografía Mamaria/métodos [Mh] Términos MeSH secundario: Femenino Humanos [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1212 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 120712 [St] Status: MEDLINE [do] DOI: 10.1148/rg.324115150

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[PMID]: 22895267 [Au] Autor: Duan X; Sneige N; Gullett AE; Prieto VG; Resetkova E; Andino LM; Wu Y; Gilcrease MZ; Bedrosian I; Dawood S; Arun B; Albarracin CT [Ad] Dirección: Department of Pathology, The University of Texas Health Science Center Department of Pathology, Houston, TX 77030, USA. [Ti] Título: Invasive paget disease of the breast: clinicopathologic study of an underrecognized entity in the breast. [So] Fuente: Am J Surg Pathol;36(9):1353-8, 2012 Sep. [Is] ISSN: 1532-0979 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: Mammary Paget disease (MPD) is considered an intraepidermal manifestation of an underlying mammary carcinoma. In contrast to extramammary Paget disease, invasion of mammary Paget cells into the dermis (invMPD) has not been reported, except for 2 cases described in Rosen's textbook. Our study was designed to identify the presence of dermal invasion of mammary Paget cells and characterize the associated clinicopathologic features. Slides from 146 MPD patients were retrieved. Six cases of invMPD were identified. One case of invMPD was not associated with an underlying breast cancer, 1 was associated with invasive ductal carcinoma (IDC), 1 with ductal carcinoma in situ (DCIS) with microinvasion, and 3 with DCIS only. The underlying breast carcinomas was separate from the area of invMPD. The depth of invasion, measured from the dermal-epidermal junction to the focus of deepest invasion, ranged from 0.02 to 0.9 mm. The horizontal extent ranged from 0.01 to 4.0 mm. Lymph node with isolated tumor clusters was present in case 1, which had no underlying carcinoma but had the greatest extent of invasion, and in case 3, which had DCIS with microinvasion. One patient (case 1) died of unrelated causes 2 years later, and the remaining patients were alive without disease at last follow-up. In summary, we describe 6 cases of MPD with invasion of Paget cells into the dermis and provide histopathologic criteria for the diagnosis of this rare and underrecognized entity. Further studies are required to determine whether invasion in MPD has clinical significance. [Mh] Términos MeSH primario: Neoplasias de la Mama/diagnóstico Carcinoma Ductal de Mama/diagnóstico Carcinoma Intraductal no Infiltrante/diagnóstico Enfermedad de Paget Mamaria/diagnóstico [Mh] Términos MeSH secundario: Adulto Anciano Neoplasias de la Mama/terapia Carcinoma Ductal de Mama/secundario Carcinoma Ductal de Mama/terapia Carcinoma Intraductal no Infiltrante/secundario Terapia Combinada Dermis/patología Femenino Humanos Ganglios Linfáticos/patología Mastectomía Mediana Edad Invasividad Neoplásica Enfermedad de Paget Mamaria/terapia Resultado del Tratamiento [Pt] Tipo de publicación: CASE REPORTS; JOURNAL ARTICLE [Em] Mes de ingreso: 1210 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 120816 [St] Status: MEDLINE [do] DOI: 10.1097/PAS.0b013e318259ef7f

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