| [PMID]: | 23025494 |
| [Au] Autor: | von Klot S; Zanobetti A; Schwartz J |
| [Ad] Dirección: | Department of Environmental Health, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA, USA. |
| [Ti] Título: | Influenza epidemics, seasonality, and the effects of cold weather on cardiac mortality. |
| [So] Fuente: | Environ Health;11:74, 2012. |
| [Is] ISSN: | 1476-069X |
| [Cp] País de publicación: | England |
| [La] Idioma: | eng |
| [Ab] Resumen: | BACKGROUND: More people die in the winter from cardiac disease, and there are competing hypotheses to explain this. The authors conducted a study in 48 US cities to determine how much of the seasonal pattern in cardiac deaths could be explained by influenza epidemics, whether that allowed a more parsimonious control for season than traditional spline models, and whether such control changed the short term association with temperature. METHODS: The authors obtained counts of daily cardiac deaths and of emergency hospital admissions of the elderly for influenza during 1992-2000. Quasi-Poisson regression models were conducted estimating the association between daily cardiac mortality, and temperature. RESULTS: Controlling for influenza admissions provided a more parsimonious model with better Generalized Cross-Validation, lower residual serial correlation, and better captured Winter peaks. The temperature-response function was not greatly affected by adjusting for influenza. The pooled estimated increase in risk for a temperature decrease from 0 to -5°C was 1.6% (95% confidence interval (CI) 1.1-2.1%). Influenza accounted for 2.3% of cardiac deaths over this period. CONCLUSIONS: The results suggest that including epidemic data explained most of the irregular seasonal pattern (about 18% of the total seasonal variation), allowing more parsimonious models than when adjusting for seasonality only with smooth functions of time. The effect of cold temperature is not confounded by epidemics. |
| [Mh] Términos MeSH primario: |
Enfermedades Cardiovasculares/mortalidad
Gripe Humana/epidemiología
Temperatura Ambiental
|
| [Mh] Términos MeSH secundario: |
Anciano
Causas de Muerte
Ciudades
Hospitalización/estadística & datos numéricos
Humanos
Estaciones
Estados Unidos/epidemiología
|
| [Pt] Tipo de publicación: | JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S. |
| [Em] Mes de ingreso: | 1305 |
| [Sb] Subgrupo de revista: | IM |
| [Da] Fecha de ingreso para procesamiento: | 121211 |
| [St] Status: | MEDLINE |
| [do] DOI: | 10.1186/1476-069X-11-74 |
