| [PMID]: | 23446675 |
| [Au] Autor: | Thomas JB; Brier MR; Snyder AZ; Vaida FF; Ances BM |
| [Ad] Dirección: | Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. |
| [Ti] Título: | Pathways to neurodegeneration: effects of HIV and aging on resting-state functional connectivity. |
| [So] Fuente: | Neurology;80(13):1186-93, 2013 Mar 26. |
| [Is] ISSN: | 1526-632X |
| [Cp] País de publicación: | United States |
| [La] Idioma: | eng |
| [Ab] Resumen: | OBJECTIVE: Resting-state functional connectivity MRI (rs-fcMRI) may provide insight into the neurophysiology of HIV and aging. METHODS: In this cross-sectional study, we used rs-fcMRI to investigate intra- and internetwork connectivity among 5 functional brain networks in 58 HIV-infected (HIV+) participants (44% receiving highly active antiretroviral therapy) and 53 HIV-uninfected (HIV-) controls. An analysis of covariance assessed the relationship among age, HIV laboratory markers, or degree of cognitive impairment and brain networks. RESULTS: Individuals who were HIV+ had decreased rs-fcMRI intranetwork correlations in the default mode (DMN, p = 0.01), control (CON, p = 0.02), and salience (SAL, p = 0.02) networks, but showed no changes in the sensorimotor (SMN) or dorsal attention (DAN) network. Compared with HIV- controls, participants who were HIV+ had a significant loss of internetwork correlations between the DMN-DAN (p = 0.02), trending loss in DMN-SAL (p = 0.1) and CON-SMN (p = 0.1), and trending increase in CON-SAL (p = 0.1). Neither HIV markers (plasma HIV viral load or CD4(+) cell count) nor degree of cognitive impairment correlated with rs-fcMRI measures. Aging correlated with a decrease in the magnitude of intranetwork functional connectivity within the DMN (p = 0.04) and SAL (p = 0.006) and with decreased magnitude of internetwork functional connectivity between DMN and SAL (p = 0.009) for both HIV+ and HIV- participants. No interaction was observed between HIV and aging. CONCLUSIONS: HIV and aging may cause independent decreases in rs-fcMRI. HIV may lead to a baseline decrease in brain function similar to deterioration that occurs with aging. |
| [Mh] Términos MeSH primario: |
Envejecimiento/fisiología
Infecciones por VIH/fisiopatología
Imagen por Resonancia Magnética
Vías Nerviosas/fisiopatología
Enfermedades Neurodegenerativas/etiología
|
| [Mh] Términos MeSH secundario: |
Adulto
Mapeo Encefálico
Femenino
Infecciones por VIH/complicaciones
Humanos
Procesamiento de Imagen Asistida por Computador
Masculino
Mediana Edad
Red Nerviosa/patología
|
| [Pt] Tipo de publicación: | JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL |
| [Em] Mes de ingreso: | 1305 |
| [Sb] Subgrupo de revista: | AIM; IM |
| [Da] Fecha de ingreso para procesamiento: | 130326 |
| [St] Status: | MEDLINE |
| [do] DOI: | 10.1212/WNL.0b013e318288792b |
