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[PMID]: 23054869 [Au] Autor: Kim YH; Jung KI; Song CH [Ad] Dirección: Department of Ophthalmology, College of Medicine, The Catholic University of Korea, Seoul, South Korea. [Ti] Título: Effects of serum calcium and magnesium on heart rate variability in adult women. [So] Fuente: Biol Trace Elem Res;150(1-3):116-22, 2012 Dec. [Is] ISSN: 1559-0720 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: The present study was designed to evaluate the association of serum calcium (Ca) and magnesium (Mg) levels with heart rate variability (HRV). One hundred and sixteen adult women were recruited in this cross-sectional study. Serum Ca and Mg levels were measured, and HRV in each time and frequency domain was recorded for 5 min. Mean heart rate and standard deviation of the normal to normal interval (SDNN) and root mean square of differences of successive RR interval (RMSSD) in time domain and total power (TP), low-frequency power (LF), high-frequency power (HF), and LF/HF ratio in frequency domain were compared according to the tertiles of serum Ca and Mg levels and Ca/Mg ratio. The associations between serum Ca and Mg levels and Ca/Mg ratio with HRV were evaluated using regression analyses. Mean heart rate tended to increase from the lowest to the highest tertile of Ca levels (p = 0.081), whereas it decreased significantly with higher Mg levels (p = 0.026). Increasing SDNN value was observed from the lowest to the highest tertile of Mg levels (p = 0.009). SDNN value decreased significantly from the lowest to the highest tertile of Ca/Mg ratio (p = 0.030). Participants in the lowest tertile of Ca/Mg ratio had significantly higher TP and LF values compared to those in the middle and highest tertiles (p < 0.05). Decreasing SDNN, TP, and LF values were significantly associated with higher Ca/Mg ratios (p < 0.05). Associations of serum Mg level and Ca/Mg ratio with HRV could be one of the mechanisms involved in cardiovascular diseases. [Mh] Términos MeSH primario: Calcio/sangre Frecuencia Cardíaca Magnesio/sangre [Mh] Términos MeSH secundario: Adulto Anciano Algoritmos Sistema Nervioso Autónomo/fisiología Sistema Nervioso Autónomo/fisiopatología Enfermedades Cardiovasculares/epidemiología Enfermedades Cardiovasculares/fisiopatología Estudios Transversales Femenino Hospitales Universitarios Hospitales Urbanos Humanos Mediana Edad Análisis de Regresión Reproducibilidad de Resultados República de Corea/epidemiología Riesgo Adulto Joven [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 7439-95-4 (Magnesium); 7440-70-2 (Calcium) [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 121130 [St] Status: MEDLINE [do] DOI: 10.1007/s12011-012-9518-2

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[PMID]: 22944520 [Au] Autor: Zuern CS; Rizas K; Eick C; Sterz K; Gawaz M; Bauer A [Ad] Dirección: Medizinische Klinik III, Eberhard-Karls-Universität Tübingen, Tübingen, Germany. [Ti] Título: Prevalence and predictors of severe autonomic failure in patients with insulin-dependent type 2 diabetes mellitus and coronary artery disease: pilot study. [So] Fuente: J Electrocardiol;45(6):774-9, 2012 Nov-Dec. [Is] ISSN: 1532-8430 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: BACKGROUND: Presence of severe autonomic failure (SAF), defined as coincidence of abnormal heart rate turbulence and abnormal deceleration capacity, identifies a group of patients with very poor prognosis among post-infarction patients with diabetes mellitus. However, factors contributing to development of SAF are entirely unknown. Here, we aimed to identify clinical, biochemical, and hemodynamic factors predicting SAF in a consecutive cohort of diabetic patients with coronary artery disease (CAD). METHODS: Between January 2010 and July 2011, we prospectively enrolled 97 patients with insulin-dependent type 2 diabetes mellitus and stable CAD in sinus rhythm. Heart rate turbulence (as marker of autonomic reflex activity) and deceleration capacity (as marker of autonomic tonic activity) were calculated from 24-hour Holter recordings. Uni- and multivariable logistic regression analysis included duration of diabetes mellitus, diabetic neuropathy, retinopathy, nephropathy, level of HbA(1c), left ventricular ejection fraction (LVEF), brain natriuretic peptide, presence of multivessel disease, and history of myocardial infarction. RESULTS: Ten (10.3%) of the 97 patients exhibited signs of SAF. Patients with SAF were characterized by longer duration of diabetes (25 years vs 15 years), higher prevalence of diabetic neuropathy (70% vs. 36%), retinopathy (80% vs 45%) and nephropathy (90% vs 55%), significantly higher levels of HbA(1c) (9.0% vs 7.4%; P = .002) and a lower LVEF (30% vs.55%; P = .001). On multivariable analysis, LVEF ≤ 35% and HbA(1c) >8% were the only factors which were independently associated with SAF (odds ratios of 23.1 [95% CI, 1.8-287.0]; P = .015 and 6.6 [1.1-40.1]; P = .043). DISCUSSION: In patients with insulin-dependent type 2 diabetes mellitus and CAD, presence of SAF correlates with both glycemic control and diabetic complications. Impaired LVEF and increased level of HbA(1c) were independently associated with SAF. [Mh] Términos MeSH primario: Enfermedades del Sistema Nervioso Autónomo/epidemiología Enfermedad de la Arteria Coronaria/epidemiología Diabetes Mellitus Tipo 1/epidemiología Disfunción Ventricular Izquierda/epidemiología [Mh] Términos MeSH secundario: Anciano Causalidad Comorbilidad Femenino Alemania/epidemiología Humanos Masculino Mediana Edad Prevalencia Pronóstico Factores de Riesgo [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 121029 [St] Status: MEDLINE

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[PMID]: 23217690 [Au] Autor: Nwazue VC; Raj SR [Ad] Dirección: Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Center, Vanderbilt University School of Medicine, AA3228 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232-2195, USA. [Ti] Título: Confounders of vasovagal syncope: orthostatic hypotension. [So] Fuente: Cardiol Clin;31(1):89-100, 2013 Feb. [Is] ISSN: 1558-2264 [Cp] País de publicación: Netherlands [La] Idioma: eng [Ab] Resumen: A syncope evaluation should start by identifying potentially life-threatening causes, including valvular heart disease, cardiomyopathies, and arrhythmias. Most patients who present with syncope, however, have the more benign vasovagal (reflex) syncope. A busy syncope practice often also sees patients with neurogenic orthostatic hypotension presenting with syncope or severe recurrent presyncope. Recognition of these potential confounders of syncope might be difficult without adequate knowledge of their presentation, and this can adversely affect optimal management. This article reviews the presentation of the vasovagal syncope confounder and the putative pathophysiology of orthostatic hypotension, and suggests options for nonpharmacologic and pharmacologic management. [Mh] Términos MeSH primario: Enfermedades del Sistema Nervioso Autónomo/complicaciones Hipotensión Ortostática/complicaciones Síncope Vasovagal/etiología [Mh] Términos MeSH secundario: Barorreflejo/fisiología Diagnóstico Diferencial Hemodinámica/fisiología Humanos Hipotensión Ortostática/diagnóstico Hipotensión Ortostática/terapia Enfermedad de Parkinson/diagnóstico Postura/fisiología Insuficiencia Autonómica Pura/complicaciones Insuficiencia Autonómica Pura/diagnóstico Síndrome de Shy-Drager/complicaciones Síndrome de Shy-Drager/diagnóstico Pruebas de Mesa Inclinada Maniobra de Valsalva/fisiología [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; REVIEW [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 121210 [St] Status: MEDLINE

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[PMID]: 22717656 [Au] Autor: Wentworth BA; Stein MB; Redwine LS; Xue Y; Taub PR; Clopton P; Nayak KR; Maisel AS [Ad] Dirección: Department of Psychiatry and Behavioral Medicine, University of California, San Diego, CA, USA. bwentwor@ucsd.edu [Ti] Título: Post-traumatic stress disorder: a fast track to premature cardiovascular disease? [So] Fuente: Cardiol Rev;21(1):16-22, 2013 Jan-Feb. [Is] ISSN: 1538-4683 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: An increasing body of evidence reported in the literature indicates a possible role for post-traumatic stress disorder (PTSD) as a cause for cardiovascular disease (CVD). However, mechanistic evidence on the progression of adverse cardiac outcomes in PTSD is lacking. In this review, we examine the potential paths by which CVD could occur in those with PTSD. Dysregulation of the hypothalamic-pituitary-adrenal axis and autonomic nervous dysfunction are commonly observed in PTSD, which in turn leads to a variety of physiological changes potentially damaging to the heart. Increased inflammation, dysfunction of the vascular endothelium, hypercoagulability, and cardiac hyperreactivity all have been noted in patients with PTSD. Altered neurochemistry, most notably increased arginine vasopressin, as well as an increased prevalence of the metabolic syndrome, may also contribute to adverse cardiac outcomes. Although the association between PTSD and physical disease is often complicated by health risk behaviors or comorbid psychiatric conditions, the evidence for a link between PTSD and CVD is substantial. In our examination, we attempt to identify potential cardiac biomarkers that may be useful in detecting increased cardiac risk in patients with PTSD. As research in this area is exceedingly limited, we hope to inspire further research, as there is great potential value in identifying prognostically useful cardiac biomarkers so as to predict and prevent the onset of CVD in patients with PTSD. [Mh] Términos MeSH primario: Marcadores Biológicos/sangre Enfermedades Cardiovasculares/psicología Trastornos por Estrés Postraumático/complicaciones [Mh] Términos MeSH secundario: Enfermedades del Sistema Nervioso Autónomo/psicología Enfermedades Cardiovasculares/fisiopatología Endotelio Vascular/fisiología Predicción Humanos Sistema Hipotálamo-Hipofisario/fisiología Enfermedades del Sistema Inmune/psicología Enfermedades Metabólicas/psicología Sistema Hipófiso-Suprarrenal/fisiología Factores de Riesgo Trastornos por Estrés Postraumático/fisiopatología [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW [Nm] Nombre de substancia: 0 (Biological Markers) [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 121205 [St] Status: MEDLINE [do] DOI: 10.1097/CRD.0b013e318265343b

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[PMID]: 22727657 [Au] Autor: Jansen K; Vandeput S; Van Huffel S; Lagae L [Ad] Dirección: Department of Pediatrics, University Hospitals Leuven, Belgium. [Ti] Título: Cardiac autonomic dysfunction in West syndrome. [So] Fuente: Epilepsy Res;102(3):167-72, 2012 Dec. [Is] ISSN: 1872-6844 [Cp] País de publicación: Netherlands [La] Idioma: eng [Ab] Resumen: BACKGROUND: West syndrome is an age-dependent epileptic encephalopathy. Autonomic changes are increasingly being recognized in patients with epilepsy: cardiac autonomic function is mediated by sympathetic and parasympathetic efferent activity to the heart and can provide information on the functional state of the autonomic nervous system. The goal of the study is to evaluate the effect of an early epileptic encephalopathy on the autonomic nervous system by measuring heart rate variability. METHODS: Cardiac autonomic function was evaluated in 13 patients with West syndrome by measuring heart rate variability during 5 min epochs of ECG in wake, stage 2 and slow wave sleep. In 5 patients who developed subsequently another type of epilepsy, a second evaluation was performed after 3 years of follow-up. RESULTS: Results showed a lower heart rate in stage 2 sleep in patients with West syndrome. Spectral components did not show significant differences compared to age matched controls at the moment of presentation. After follow-up of 3 years we were able to demonstrate higher low frequency (LF), lower high frequency (HF) and a higher LF/HF ratio during slow wave sleep. CONCLUSION: This study shows a lower heart rate in patients presenting with West syndrome, already at the onset of the syndrome and before ACTH treatment. The epileptic encephalopathy is not sufficient to alter spectral components of heart rate at the moment of presentation. However, already after 3 years of epilepsy, chronic autonomic changes appear. [Mh] Términos MeSH primario: Enfermedades del Sistema Nervioso Autónomo/etiología Cardiopatías/etiología Frecuencia Cardíaca/fisiología Espasmos Infantiles/complicaciones [Mh] Términos MeSH secundario: Edad de Inicio Anticonvulsivantes/uso terapéutico Enfermedades del Sistema Nervioso Autónomo/diagnóstico Enfermedades del Sistema Nervioso Autónomo/quimioterapia Niño Preescolar Estudios de Cohortes Electrocardiografía Electroencefalografía Femenino Cardiopatías/diagnóstico Cardiopatías/quimioterapia Humanos Lactante Masculino Espasmos Infantiles/quimioterapia Análisis Espectral [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (Anticonvulsants) [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 121130 [St] Status: MEDLINE

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[PMID]: 23547408 [Au] Autor: Sinha PK; Santr G; De D; Sah A; Biswas K; Bhattachary P; Ghosh P [Ad] Dirección: Dept. of Medicine, Medical College, 88 College Street, Kolkata-700073. [Ti] Título: Carotid intima-media thickness in type 2 diabetes mellitus patients with cardiac autonomic neuropathy. [So] Fuente: J Assoc Physicians India;60:14-8, 2012 Sep. [Is] ISSN: 0004-5772 [Cp] País de publicación: India [La] Idioma: eng [Ab] Resumen: INTRODUCTION: Cardiac autonomic neuropathy (CAN) is an important complication of type 2 diabetes mellitus (T2DM). Accelerated atherosclerosis is also common in T2DM. Carotid intima media thickness (CIMT) is a surrogate marker of atherosclerosis. We conducted a study to assess the CIMT in T2DM patients with CAN. METHODS: In 84 T2DM patients cardiac autonomic function was assessed by five clinical tests including: 1) heart rate variation during deep breathing, 2) hear rate response to standing, 3) Valsalva ratio, 4) postural fall in systolic blood pressure (BP) three minutes after standing, and 5) resting heart rate. CAN was defined as two or more positive tests out of five for cardiac autonomic function. CIMT was measured by two dimensional (2D) ultrasound. We also examined for presence of any atherosclerotic plaque over intima of carotid artery as well as within the carotid bulb. RESULTS: Thirty six (42.85 percent) out of 84 patients were detected to have CAN. CAN was significantly associated with duration of disease after its detection (P = 0.0253), high LDL cholesterol (P = 0.0418), low HDL cholesterol (P = 0.0001), fasting blood sugar (FBS) level (P = 0.0012) and CIMT (P = 0.0001) equal to or more than 69 mm. CONCLUSION: Increased CIMT equal to or more than 69 mm is associated with high occurrence of CAN in diabetic population. Duration of diabetes, abnormal lipid tests and FBS level significantly influence the development of CAN. [Mh] Términos MeSH primario: Enfermedades del Sistema Nervioso Autónomo/complicaciones Grosor Intima-Media Carotídeo Diabetes Mellitus Tipo 2/complicaciones Neuropatías Diabéticas/fisiopatología [Mh] Términos MeSH secundario: Adulto Anciano Enfermedades del Sistema Nervioso Autónomo/ultrasonografía Presión Sanguínea/fisiología LDL-Colesterol Diabetes Mellitus Tipo 2/ultrasonografía Femenino Pruebas de Función Cardíaca Frecuencia Cardíaca/fisiología Humanos Masculino Mediana Edad Análisis Multivariante Prevalencia Factores de Riesgo Sensibilidad y Especificidad [Pt] Tipo de publicación: JOURNAL ARTICLE [Nm] Nombre de substancia: 0 (Cholesterol, LDL) [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 130403 [St] Status: MEDLINE

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[PMID]: 23547406 [Au] Autor: Mohan V; Pradeep R [Ti] Título: Carotid intima-media thickness in type 2 diabetes mellitus. [So] Fuente: J Assoc Physicians India;60:9-10, 2012 Sep. [Is] ISSN: 0004-5772 [Cp] País de publicación: India [La] Idioma: eng [Mh] Términos MeSH primario: Aterosclerosis/complicaciones Enfermedades del Sistema Nervioso Autónomo/complicaciones Grosor Intima-Media Carotídeo Diabetes Mellitus Tipo 2/complicaciones Angiopatías Diabéticas/diagnóstico Neuropatías Diabéticas/fisiopatología Obesidad Abdominal/complicaciones [Mh] Términos MeSH secundario: Femenino Humanos Masculino [Pt] Tipo de publicación: COMMENT; EDITORIAL [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 130403 [St] Status: MEDLINE

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[PMID]: 23467373 [Au] Autor: Quach DH; Oliveira-Fernandes M; Gruner KA; Tourtellotte WG [Ad] Dirección: Department of Pathology (Division of Neuropathology), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA. [Ti] Título: A sympathetic neuron autonomous role for Egr3-mediated gene regulation in dendrite morphogenesis and target tissue innervation. [So] Fuente: J Neurosci;33(10):4570-83, 2013 Mar 6. [Is] ISSN: 1529-2401 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: Egr3 is a nerve growth factor (NGF)-induced transcriptional regulator that is essential for normal sympathetic nervous system development. Mice lacking Egr3 in the germline have sympathetic target tissue innervation abnormalities and physiologic sympathetic dysfunction similar to humans with dysautonomia. However, since Egr3 is widely expressed and has pleiotropic function, it has not been clear whether it has a role within sympathetic neurons and if so, what target genes it regulates to facilitate target tissue innervation. Here, we show that Egr3 expression within sympathetic neurons is required for their normal innervation since isolated sympathetic neurons lacking Egr3 have neurite outgrowth abnormalities when treated with NGF and mice with sympathetic neuron-restricted Egr3 ablation have target tissue innervation abnormalities similar to mice lacking Egr3 in all tissues. Microarray analysis performed on sympathetic neurons identified many target genes deregulated in the absence of Egr3, with some of the most significantly deregulated genes having roles in axonogenesis, dendritogenesis, and axon guidance. Using a novel genetic technique to visualize axons and dendrites in a subpopulation of randomly labeled sympathetic neurons, we found that Egr3 has an essential role in regulating sympathetic neuron dendrite morphology and terminal axon branching, but not in regulating sympathetic axon guidance to their targets. Together, these results indicate that Egr3 has a sympathetic neuron autonomous role in sympathetic nervous system development that involves modulating downstream target genes affecting the outgrowth and branching of sympathetic neuron dendrites and axons. [Mh] Términos MeSH primario: Dendritas/metabolismo Ganglios Simpáticos/citología Regulación de la Expresión Génica/genética Neuronas/citología Sistema Nervioso Simpático/fisiología [Mh] Términos MeSH secundario: Animales Enfermedades del Sistema Nervioso Autónomo/genética Enfermedades del Sistema Nervioso Autónomo/patología Axones/efectos de drogas Axones/fisiología Proteína Quinasa Tipo 2 Dependiente de Calcio Calmodulina/genética Células Cultivadas Dendritas/efectos de drogas Dopamina beta-Hidroxilasa/genética Proteína 3 de la Respuesta de Crecimiento Precoz/genética Electroporación Perfilación de la Expresión Génica Regulación de la Expresión Génica/efectos de drogas Proteinas Fluorescentes Verdes/genética Ratones Ratones Consanguíneos C57BL Ratones Transgénicos Mutación/genética Factor de Crecimiento Nervioso/farmacología Neuronas/efectos de drogas ARN Mensajero/metabolismo Sistema Nervioso Simpático/citología Tirosina 3-Monooxigenasa/metabolismo Proteína X Asociada a bcl-2/genética beta-Galactosidasa/metabolismo [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL [Nm] Nombre de substancia: 0 (Egr3 protein, mouse); 0 (RNA, Messenger); 0 (bcl-2-Associated X Protein); 0 (enhanced green fluorescent protein); 144516-98-3 (Early Growth Response Protein 3); 147336-22-9 (Green Fluorescent Proteins); 9061-61-4 (Nerve Growth Factor); EC 1.14.16.2 (Tyrosine 3-Monooxygenase); EC 1.14.17.1 (Dopamine beta-Hydroxylase); EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2); EC 3.2.1.23 (beta-Galactosidase) [Em] Mes de ingreso: 1304 [Cu] Fecha actualización por clase: 130506 [Lr] Fecha última revisión: 130506 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 130307 [St] Status: MEDLINE [do] DOI: 10.1523/JNEUROSCI.5481-12.2013

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[PMID]: 23486957 [Au] Autor: Lingappa JR; Zigmond RE [Ad] Dirección: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA. jais@u.washington.edu [Ti] Título: Limited recovery of pineal function after regeneration of preganglionic sympathetic axons: evidence for loss of ganglionic synaptic specificity. [So] Fuente: J Neurosci;33(11):4867-74, 2013 Mar 13. [Is] ISSN: 1529-2401 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: The cervical sympathetic trunks (CSTs) contain axons of preganglionic neurons that innervate the superior cervical ganglia (SCGs). Because regeneration of CST fibers can be extensive and can reestablish certain specific patterns of SCG connections, restoration of end organ function would be expected. This expectation was examined with respect to the pineal gland, an organ innervated by the two SCGs. The activity of pineal serotonin N-acetyltransferase (NAT) exhibits a large circadian rhythm that is dependent on the sympathetic input of the gland, with high activity at night. Thirty-six hours after the CSTs were crushed bilaterally, nocturnal NAT was decreased by 99%. Three months later, enzyme activity had recovered only to 15% of control values, a recovery dependent on regeneration of CST fibers. Nevertheless, a small day/night rhythm was present in lesioned animals. Neither the density of the adrenergic innervation of the gland nor the ability of an adrenergic agonist to stimulate NAT activity was reduced in rats with regenerated CSTs. In addition, stimulation of the regenerated CST at a variety of frequencies was at least as effective in increasing NAT activity as seen with control nerves. These data suggest that the failure of pineal function to recover is not attributable to a quantitative deficit in the extent of reinnervation or synaptic efficacy. Rather, we suggest that there is some loss of specificity in the synaptic connections made in the SCG during reinnervation, resulting in a loss of the central neuronal information necessary for directing a normal NAT rhythm and thus normal pineal function. [Mh] Términos MeSH primario: Enfermedades del Sistema Nervioso Autónomo/patología Enfermedades del Sistema Nervioso Autónomo/fisiopatología Axones/patología Regeneración Nerviosa/fisiología Glándula Pineal/fisiopatología Ganglio Cervical Superior/patología [Mh] Términos MeSH secundario: Animales N-Acetiltransferasa de Arilalquilamina/metabolismo Axones/efectos de drogas Biofisica Brocresina/farmacología Ritmo Circadiano/fisiología Modelos Animales de Enfermedad Relación Dosis-Respuesta a Droga Estimulación Eléctrica Inhibidores Enzimáticos/farmacología Regulación Enzimológica de la Expresión Génica/fisiología Isoproterenol/farmacología Masculino Nordefrin/farmacología Glándula Pineal/metabolismo Ratas Ratas Sprague-Dawley Ganglio Cervical Superior/efectos de drogas Simpatomiméticos/farmacología Factores de Tiempo Tirosina 3-Monooxigenasa [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL [Nm] Nombre de substancia: 0 (Enzyme Inhibitors); 0 (Sympathomimetics); 555-65-7 (Brocresine); 6539-57-7 (Nordefrin); 7683-59-2 (Isoproterenol); EC 1.14.16.2 (Tyrosine 3-Monooxygenase); EC 2.3.1.87 (Arylalkylamine N-Acetyltransferase) [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 130314 [St] Status: MEDLINE [do] DOI: 10.1523/JNEUROSCI.3829-12.2013

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[PMID]: 22683093 [Au] Autor: Gratzke C [Ti] Título: Of mice and men: animal models in functional urology. [So] Fuente: Eur Urol;62(6):1086-7, 2012 Dec. [Is] ISSN: 1873-7560 [Cp] País de publicación: Switzerland [La] Idioma: eng [Mh] Términos MeSH primario: Enfermedades del Sistema Nervioso Autónomo/quimioterapia Enfermedades del Sistema Nervioso Autónomo/etiología Betametasona/uso terapéutico Enfermedades Urogenitales Femeninas/cirugía Glucocorticoides/uso terapéutico Procedimientos Quirúrgicos Ginecológicos/efectos adversos Plexo Hipogástrico Enfermedades de la Vejiga Urinaria/quimioterapia Enfermedades de la Vejiga Urinaria/etiología Procedimientos Quirúrgicos Urológicos/efectos adversos [Mh] Términos MeSH secundario: Animales Femenino [Pt] Tipo de publicación: COMMENT; EDITORIAL [Nm] Nombre de substancia: 0 (Glucocorticoids); 378-44-9 (Betamethasone) [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 121112 [St] Status: MEDLINE

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