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Fotocopia
[PMID]:23230672
[Au] Autor:Zeng L; Shan W; Yuan M; Huang G; Huang L
[Ad] Dirección:Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
[Ti] Título:[Longitudinal preputial pedicled flap urethroplasty for chordee of Donnahoo type IV].
[So] Fuente:Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi;26(11):1352-5, 2012 Nov.
[Is] ISSN:1002-1892
[Cp] País de publicación:China
[La] Idioma:chi
[Ab] Resumen:OBJECTIVE: To investigate the effectiveness of longitudinal preputial pedicled flap urethroplasty for chordee of Donnahoo IV type. METHODS: Between June 1994 and October 2011, 30 patients with chordee (Donnahoo type IV) underwent longitudinal preputial pedicled flap urethroplasty. The patients' age ranged from 2 to 16 years (mean, 5.8 years). The morphology of the balanus-navicular fossa-external urethral orifice ranged normal; the penis length was 2.5-6.8 cm (mean, 4.3 cm); the penis bending angle was 35-70 degrees (mean, 40.1 degrees). Primary and secondary operation was 27 cases and 3 cases, respectively. The size of flap ranged from 1.5 cm x 1.3 cm to 4.0 cm x 2.0 cm. RESULTS: After correction, the penis length was 3.0-8.5 cm (mean, 6.6 cm); the penis bending angle was 0-10 degrees (mean, 1.2 degrees). All patients were followed up 6 months to 12 years (mean, 33 months). No recurrence, stabbing pain of the balanus, or foreign body sensation occurred during follow-up. Of them, 4 patients (13.33%) had urinary fistular, they had satisfactory results after the second operation; 2 patients (6.67%) had urethral stricture 1 month after operation, they also had satisfactory results after arethral dilatation. The other patients showed no scattering urinary flow and good direction without complication. Six patients had satisfactory sexual function after puberty without erection disorder, pain, or dyspareunia. CONCLUSION: Longitudinal preputial pedicled flap urethroplasty can achieve maximum utilization of prepuce and aesthetic and functional improvement with less complication, so it is a relatively ideal mean for treating chordee of Donnahoo type IV.
[Mh] Términos MeSH primario: Pene/anomalías
Pene/cirugía
Colgajos Quirúrgicos
Anomalías Urogenitales/cirugía
[Mh] Términos MeSH secundario: Adolescente
Niño
Preescolar
Estudios de Seguimiento
Prepucio/cirugía
Humanos
Masculino
Complicaciones Postoperatorias/etiología
Complicaciones Postoperatorias/cirugía
Colgajos Quirúrgicos/irrigación sanguínea
Técnicas de Sutura
Resultado del Tratamiento
Uretra/cirugía
Estrechez Uretral/etiología
Fístula Urinaria/etiología
Fístula Urinaria/cirugía
Anomalías Urogenitales/patología
[Pt] Tipo de publicación:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mes de ingreso:1305
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:121212
[St] Status:MEDLINE


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Fotocopia
[PMID]:23040621
[Au] Autor:Dillon BE; Gurbuz C; Zimmern PE
[Ad] Dirección:Department of Urology, University of Texas Southwestern Medical Center, Dallas, 75390-9110, USA.
[Ti] Título:Long term results after complication of "prophylactic" suburethral tape placement.
[So] Fuente:Can J Urol;19(5):6424-30, 2012 Oct.
[Is] ISSN:1195-9479
[Cp] País de publicación:Canada
[La] Idioma:eng
[Ab] Resumen:INTRODUCTION: To report the long term result following complications that arose after "prophylactic" placement of midurethral sling (MUS) during prolapse repair. MATERIALS AND METHODS: After institutional review board approval, the records of patients who presented with complications of prophylactic MUS and had a minimum 1 year follow up after repair of their complication were reviewed. Data collected included age, body mass index, operative note documenting primary procedure and type of prophylactic MUS, indication for prophylactic MUS, presenting complaint, duration and severity of symptoms since MUS placement, operative events if any, and outcomes after repair of the complication. RESULTS: Between 2007 and 2009, ten patients presented with complications of prophylactic MUS and underwent transvaginal suburethral tape excision. At a median 35 (mean 36) month follow up post-MUS excision, a secondary midurethral stricture, an infected paravesical retropubic tape, and symptomatic incontinence and/or secondary anterior compartment prolapse requiring additional repair in five patients, occurred. Three patients experienced residual lower urinary tract symptoms (LUTS). Pain resolved in all four patients. CONCLUSION: "Prophylactic" placement of a MUS can be fraught with complications requiring MUS removal, followed by additional corrective surgery in some, and persistent LUTS managed by continuous pharmacological therapy in others, thus requiring careful consideration and full patient agreement.
[Mh] Términos MeSH primario: Remoción de Dispositivos
Falla de Prótesis/efectos adversos
Cabestrillo Suburetral/efectos adversos
[Mh] Términos MeSH secundario: Adulto
Anciano
Dispareunia/etiología
Femenino
Estudios de Seguimiento
Humanos
Síntomas del Sistema Urinario Inferior/etiología
Mediana Edad
Prolapso de Órgano Pélvico/etiología
Dolor Pélvico/etiología
Calidad de Vida
Recurrencia
Factores de Tiempo
Estrechez Uretral/etiología
Incontinencia Urinaria/etiología
Infecciones Urinarias/etiología
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1304
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:121008
[St] Status:MEDLINE


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Texto completo
[PMID]:21989815
[Au] Autor:Bastian PJ; Mayer M; Tritschler S; Roosen A; Nuhn P; Bauer RM; Gozzi C
[Ad] Dirección:Urologische Klinik und Poliklinik, Klinikun der Universität München-Campus Großhadern, Ludwig-Maximilians-Universität, Marchioninistr. 15, 81377 Munich, Germany. patrick.bastian@med.uni-muenchen.de
[Ti] Título:Single-stage dorsal inlay for reconstruction of recurrent peno-glandular stenosis.
[So] Fuente:World J Urol;30(5):715-21, 2012 Oct.
[Is] ISSN:1433-8726
[Cp] País de publicación:Germany
[La] Idioma:eng
[Ab] Resumen:OBJECTIVE: To evaluate the validity of a single-stage dorsal inlay for recurrent peno-glandular stenosis following previous endourological or open urethroplastic surgery. Urethral glanular reconstruction included a deep dorsal incision followed by complete scar excision to create a deep groove presenting well-vascularized recipient bed ensuring appropriate graft healing. MATERIALS AND METHODS: Between April 2002 and January 2008, a total of 34 patients (mean age 51.5 years, 14-85 years) were enrolled in the study. Congenital anomalies included hypospadia (n = 19, 53%) and epispadia (n = 2, 6%). Condition of strictures was either iatrogenic (n = 7), due to infection (n = 5), or traumatic (n = 1). Foreskin grafts were used in 13 cases, foreskin and buccal mucosa in one case, penile skin in 6 cases, and inguinal skin/thigh (harvested by electrodermatom) in 14 cases. The combination of meticulous scar excision with a deep incision of the glans was used to provide a well-vascularized grafting bed, thus ensuring excellent graft healing. The outcome analysis included urinary flow, urethral calibration >18 ch, voiding cystometry, and patient's satisfaction in a follow-up regime every 3 months. RESULTS: The average graft length was 4.7 cm (median 8, range 1.5-14). Mean follow-up was 70 months. In 31 patients (91%), no recurrent glanular stenosis was observed resulting in a post-operative flow of average 26.2 ml/s (11-53). Three post-operative wound infections occurred resulting in stricture recurrence, which was treated with internal urethrotomy, buccal mucosa, or penile skin inlay, respectively. Cosmetic results were satisfactory in all patients. Post-operative voiding parameters were significantly improved (P < 0.001). CONCLUSION: The single-stage dorsal inlay for reconstruction of peno-glandular stenosis represents a reliable method even if the urethral plate is severely scarred or has been excised during previous surgery. The good results imply that a well-vascularized graft and the technical approach seem to be more important than the substitute material.
[Mh] Términos MeSH primario: Hipospadias/cirugía
Enfermedades del Pene/cirugía
Procedimientos Quirúrgicos Reconstructivos/métodos
Procedimientos Quirúrgicos Reconstructivos/normas
Uretra/cirugía
Estrechez Uretral/cirugía
[Mh] Términos MeSH secundario: Adolescente
Adulto
Anciano
Anciano de 80 o más Años
Estudios de Cohortes
Constricción Patológica/cirugía
Estudios de Seguimiento
Humanos
Hipospadias/patología
Masculino
Mediana Edad
Recurrencia
Reoperación/métodos
Reoperación/normas
Trasplante de Piel/métodos
Trasplante de Piel/normas
Uretra/anomalías
Adulto Joven
[Pt] Tipo de publicación:CLINICAL TRIAL; JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mes de ingreso:1304
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:121105
[St] Status:MEDLINE
[do] DOI:10.1007/s00345-011-0770-4


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Fotocopia
Texto completo
[PMID]:22985312
[Au] Autor:Pfalzgraf D; Kluth L; Isbarn H; Reiss P; Riechardt S; Fisch M; Dahlem R
[Ad] Dirección:Department of Urology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. dpfalzgraf@uke.uni-hamburg.de
[Ti] Título:The Barbagli technique: 3-year experience with a modified approach.
[So] Fuente:BJU Int;111(3 Pt B):E132-6, 2013 Mar.
[Is] ISSN:1464-410X
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:UNLABELLED: What's known on the subject? and What does the study add? Urethral strictures can be treated by various methods, e.g. dilatation and endoscopic treatment, as well as with open surgery. However, transurethral treatment shows low long-time success rates, while open urethral reconstruction yields good long-term results. One of the standard procedures to reconstruct the strictured penile urethra is the Barbagli technique, which was introduced in 1996. However, a potential drawback of this technique is the suturing of the urethral margins to the second side of the graft, because the buccal mucosa is already fixed to the corpus cavernosum and the last line is sutured in the back side of the urethra out of sight. The present study aims to assess whether the functional results are compromised by a modified Barbagli technique, which enables a better visualisation of the mucosal margins while making the anastomosis, simplifying the original technique. OBJECTIVE: To evaluate stricture recurrence rate as well as the satisfaction with the surgery of patients treated with a modified Barbagli technique published by our study group in 2009. PATIENTS AND METHODS: Retrospective analysis by patient's chart review and unvalidated standardised questionnaire of patients treated by the modified Barbagli technique for urethral stricture between May 2008 and September 2010. In all, 22 patients were treated with the modified Barbagli technique for urethral stricture during this time, and 18 patients were available for follow-up. Previous surgeries, recurrence rate, complications, incontinence, erectile function, satisfaction with the surgery, and oral numbness were assessed. As described in the original technique, also in the modified technique the access to the urethra is achieved through a midline incision. Subsequently, the urethra is completely mobilised. However, it is then rotated 180 ° using stay sutures. Afterwards, the buccal mucosa is sutured into the opened urethra on both sides under vision, giving free access to the margins. Once the buccal mucosa is completely sutured in, the urethra is back-rotated using stay sutures and the margin of the buccal mucosa and the urethra is sutured to the tunica albuginea, stretching and supporting the buccal mucosa. RESULTS: Follow-up was available for 18 patients with a mean (range) age of 67.5 (27-74) years. Open previous surgeries had been performed in 27.8% and transurethral surgeries in 72.2%. The mean (range) length of the oral mucosa graft was 7.8 (2.5-13) cm and the mean operative duration was 106 (73-193) min. The success rate was 83.2%; there was no de novo erectile dysfunction and no relevant penile curvature. There was oral numbness in two patients (9%). None of the recurrence-free patients (83.3%) were dissatisfied with the surgery. CONCLUSIONS: The technique simplifies the original technique without compromising the functional results. The modification of the technique enables a better visualisation of the mucosal margins while making the anastomosis, simplifying the original technique. The success rate was comparable with the original technique and patient satisfaction with the surgery was high.
[Mh] Términos MeSH primario: Estrechez Uretral/cirugía
[Mh] Términos MeSH secundario: Adulto
Anciano
Humanos
Mediana Edad
Estudios Retrospectivos
Factores de Tiempo
Procedimientos Quirúrgicos Urológicos Masculinos/métodos
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1304
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:130304
[St] Status:MEDLINE
[do] DOI:10.1111/j.1464-410X.2012.11399.x


  5 / 3569 MEDLINE  
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Fotocopia
Texto completo
[PMID]:23374824
[Au] Autor:DeLong J; Buckley J
[Ad] Dirección:Institute of Urology, Lahey Clinic, Burlington, MA 01805, USA.
[Ti] Título:Patient-reported outcomes combined with objective data to evaluate outcomes after urethral reconstruction.
[So] Fuente:Urology;81(2):432-6, 2013 Feb.
[Is] ISSN:1527-9995
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:OBJECTIVE: To report patients' perceptions of urethral reconstruction outcomes by comparing the results from preoperative and postoperative symptom questionnaires and to propose a standardized method of follow-up that includes patient satisfaction questionnaires and objective cystoscopic evaluation to facilitate comparison of different urethral reconstructive techniques and outcomes among surgeons and institutions. MATERIALS AND METHODS: Data were prospectively collected for 110 consecutive patients undergoing urethral reconstruction. Patient demographics, American Urological Association Symptom Score, quality of life score, International Index of Erectile Function score, flow rate, and postvoid residual urine volume were collected pre- and postoperatively. The patients were evaluated at 3 and 6 months postoperatively and then yearly. Flexible cystoscopy (17F) was performed at 6 months postoperatively. The Wilcoxon signed rank test and Mann-Whitney U test were used to compare the pre- and post-test distributions. One-way analysis of variance was used to compare the mean values among groups. RESULTS: The mean patient age was 47 years, and the mean stricture length was 4.9 cm. Of the 110 patients, 32 received anastomotic (29%), 60 onlay (55%), 7 staged (6%), and 11 fasciocutaneous flap (10%) urethroplasty. The median individual change comparing the pre- and postoperative data was an improvement of 11 for the American Urological Association Symptom Score (P <.0001), 4 for the quality of life score (P <.0001), and 0 for International Index of Erectile Function (P = .05). No unifying individual follow-up questionnaire or flow rate correlated with recurrence. CONCLUSION: Patients undergoing urethral reconstruction reported significant improvement in urinary bother and quality of life scores while maintaining or improving their erectile function. Cystoscopic evaluation can be a valuable component of the postoperative follow-up algorithm, providing a consistent data point for comparison and confirming the patency of repair. Standardization of the measured outcomes is critical to validate the reported urethral reconstructive outcomes.
[Mh] Términos MeSH primario: Satisfacción del Paciente
Uretra/cirugía
Estrechez Uretral/cirugía
Procedimientos Quirúrgicos Urológicos Masculinos/métodos
[Mh] Términos MeSH secundario: Adolescente
Adulto
Anciano
Anciano de 80 o más Años
Cistoscopía
Humanos
Masculino
Mediana Edad
Erección Peniana
Calidad de Vida
Cuestionarios
Recurrencia
Estadísticas no Paramétricas
Uretra/patología
Urodinámica
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1304
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:130204
[St] Status:MEDLINE


  6 / 3569 MEDLINE  
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Texto completo
[PMID]:23374792
[Au] Autor:Liss MA; Skarecky D; Morales B; Osann K; Eichel L; Ahlering TE
[Ad] Dirección:Department of Urology, University of California, Irvine, CA, USA. mliss@ucsd.edu
[Ti] Título:Preventing perioperative complications of robotic-assisted radical prostatectomy.
[So] Fuente:Urology;81(2):319-23, 2013 Feb.
[Is] ISSN:1527-9995
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:OBJECTIVE: To report the change in complication rates after the identification and modification of technique to reduce their incidence during robot-assisted radical prostatectomy (RARP). METHODS: This study retrospectively reviewed 1000 consecutive patients who underwent RARP from June 2002 to June 2011. A number of technical changes were made after complications were noted and changes in technique were documented. The Fisher exact test and multivariate analysis were used for comparison of techniques, and values of P <.05 were considered significant. RESULTS: The overall rate of major and minor complications was 10.8% (108 of 1000). The complication rates of lymphoceles (0.4%), ileus (0.4%), and wound infection (0.4%) were low and did not require technical changes. There were no significant changes in rates of femoral nerve palsies, rectal injuries, or bladder neck contractures. There was statistically significant change in corneal abrasions (P = .03), fossa navicularis strictures (P = .03), and camera-site hernias (P <.001) after a directed intervention adjusted for age, body mass index, and learning curve. Clavien 3 and 4 complications all significantly decreased to ≤ 0.6%, with the most occurring in the first 200 cases. CONCLUSION: Identification and correction of perioperative complications in patients undergoing robotic prostatectomy has decreased the incidence of major and minor complications adjusted for learning curve. The conscientious monitoring of adverse events can provide targeted change in technique to decrease complications and provide information to those early in learning robotic-assisted radical prostatectomy.
[Mh] Términos MeSH primario: Curva de Aprendizaje
Prostatectomía/efectos adversos
Prostatectomía/métodos
[Mh] Términos MeSH secundario: Índice de Masa Corporal
Competencia Clínica
Hernia/etiología
Hernia/prevención & control
Humanos
Ileus/etiología
Ileus/prevención & control
Linfocele/etiología
Linfocele/prevención & control
Masculino
Mediana Edad
Análisis Multivariante
Periodo Perioperatorio
Neoplasias de la Próstata/cirugía
Embolia Pulmonar/etiología
Embolia Pulmonar/prevención & control
Recto/lesiones
Estudios Retrospectivos
Robótica
Infección de Herida Operatoria/etiología
Infección de Herida Operatoria/prevención & control
Estrechez Uretral/etiología
Estrechez Uretral/prevención & control
Enfermedades de la Vejiga Urinaria/etiología
Enfermedades de la Vejiga Urinaria/prevención & control
Trombosis de la Vena/etiología
Trombosis de la Vena/prevención & control
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1304
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:130204
[St] Status:MEDLINE


  7 / 3569 MEDLINE  
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Fotocopia
PubMed Central Texto completo
Texto completo
[PMID]:23083654
[Au] Autor:Blaschko SD; McAninch JW; Myers JB; Schlomer BJ; Breyer BN
[Ad] Dirección:Department of Urology, University of California-San Francisco, San Francisco, California 94117, USA.
[Ti] Título:Repeat urethroplasty after failed urethral reconstruction: outcome analysis of 130 patients.
[So] Fuente:J Urol;188(6):2260-4, 2012 Dec.
[Is] ISSN:1527-3792
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:PURPOSE: Male urethral stricture disease accounts for a significant number of hospital admissions and health care expenditures. Although much research has been completed on treatment for urethral strictures, fewer studies have addressed the treatment of strictures in men with recurrent stricture disease after failed prior urethroplasty. We examined outcome results for repeat urethroplasty. MATERIALS AND METHODS: A prospectively collected, single surgeon urethroplasty database was queried from 1977 to 2011 for patients treated with repeat urethroplasty after failed prior urethral reconstruction. Stricture length and location, and repeat urethroplasty intervention and failure were evaluated with descriptive statistics, and univariate and multivariate logistic regression. RESULTS: Of 1,156 cases 168 patients underwent repeat urethroplasty after at least 1 failed prior urethroplasty. Of these patients 130 had a followup of 6 months or more and were included in analysis. Median patient age was 44 years (range 11 to 75). Median followup was 55 months (range 6 months to 20.75 years). Overall, 102 of 130 patients (78%) were successfully treated. For patients with failure median time to failure was 17 months (range 7 months to 16.8 years). Two or more failed prior urethroplasties and comorbidities associated with urethral stricture disease were associated with an increased risk of repeat urethroplasty failure. CONCLUSIONS: Repeat urethroplasty is a successful treatment option. Patients in whom treatment failed had longer strictures and more complex repairs.
[Mh] Términos MeSH primario: Uretra/cirugía
Estrechez Uretral/cirugía
[Mh] Términos MeSH secundario: Adolescente
Adulto
Anciano
Niño
Humanos
Masculino
Mediana Edad
Estudios Prospectivos
Reoperación
Insuficiencia del Tratamiento
Resultado del Tratamiento
Procedimientos Quirúrgicos Urológicos Masculinos/métodos
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mes de ingreso:1301
[Cu] Fecha actualización por clase:130411
[Lr] Fecha última revisión:130411
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:121112
[St] Status:MEDLINE


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PubMed Central Texto completo
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[PMID]:21664873
[Au] Autor:Voelzke BB; Breyer BN; McAninch JW
[Ad] Dirección:San Francisco General Hospital, San Francisco, CA 94110, USA. voelzke@uw.edu
[Ti] Título:Blunt pediatric anterior and posterior urethral trauma: 32-year experience and outcomes.
[So] Fuente:J Pediatr Urol;8(3):258-63, 2012 Jun.
[Is] ISSN:1873-4898
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:OBJECTIVE: To analyze our experience with delayed repair of pediatric urethral trauma. MATERIALS AND METHODS: From 1978 to 2007, 26 boys <18 years old (mean age 15.0) presented for delayed repair of urethral stricture after blunt trauma. Anterior and posterior urethral injuries were separately stratified. RESULTS: There were 8 anterior and 18 posterior urethral strictures. All patients presented in a delayed fashion. Mean follow up of the anterior cohort was 2.9 years. All repairs were performed via a ventral onlay buccal graft or anastomotic approach. The mean follow up of the posterior cohort was 1.1 years, and all posterior urethral injuries were repaired via an anastomotic approach. Overall success for anterior stricture disease was 88.9% and for posterior stricture disease was 89.5%. All three urethroplasty failures responded favorably to internal urethrotomy; however, one failed anterior repair and one of the two failed posterior repairs required two internal urethrotomy operations for success. No secondary urethroplasty operations were required and ultimately all patients were voiding per urethra without need for urethral dilation. CONCLUSION: Delayed, definitive repair of pediatric urethral trauma via open urethroplasty has a high success rate.
[Mh] Términos MeSH primario: Traumatismos Abdominales/complicaciones
Procedimientos Quirúrgicos Reconstructivos/métodos
Uretra/lesiones
Estrechez Uretral/etiología
Procedimientos Quirúrgicos Urológicos Masculinos/métodos
Heridas no Penetrantes/complicaciones
[Mh] Términos MeSH secundario: Traumatismos Abdominales/diagnóstico
Traumatismos Abdominales/cirugía
Adolescente
Anastomosis Quirúrgica
Estudios de Seguimiento
Humanos
Masculino
Mucosa Bucal/trasplante
Perineo/lesiones
Perineo/cirugía
Estudios Retrospectivos
Factores de Tiempo
Índices de Gravedad del Trauma
Resultado del Tratamiento
Uretra/cirugía
Estrechez Uretral/diagnóstico
Estrechez Uretral/cirugía
Micción
Heridas no Penetrantes/diagnóstico
Heridas no Penetrantes/cirugía
[Pt] Tipo de publicación:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mes de ingreso:1211
[Cu] Fecha actualización por clase:130411
[Lr] Fecha última revisión:130411
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:120515
[St] Status:MEDLINE
[do] DOI:10.1016/j.jpurol.2011.05.010


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[PMID]:23134920
[Au] Autor:Haque ME; Rahman MA; Islam MF; Siddique FH; Uddin MM; Khondoker MI; Kaiser I; Siddiqui O; Karim MM; Saha P; Salam MA
[Ad] Dirección:National Institute of Cancer Research and Hospital, Mohakhali, Dhaka, Bangladesh.
[Ti] Título:Ventral free oral mucous membrane graft for bulbar urethral stricture.
[So] Fuente:Mymensingh Med J;21(4):696-701, 2012 Oct.
[Is] ISSN:1022-4742
[Cp] País de publicación:Bangladesh
[La] Idioma:eng
[Ab] Resumen:The use of oral mucous membrane graft onlay urethroplasty represents the most widespread method of bulbar urethral stricture repair. We investigated the short term result of oral mucous membrane graft placed on the ventral surface for management of bulbar urethral stricture. Patients with Bulbar urethral stricture of any length, infection free urinary tract and informed consent for oral mucosa harvesting and urethroplasty were selected for study. We enrolled 108 cases of bulbar urethral stricture patients from January 2004 to July 2009. The mean ± SD preoperative maximum flow rate of 5.2 ± 2.6 ml/sec and mean ± SD PVR 87 ± 58.3 ml were treated by substitution urethroplasty with oral mucous membrane by a single surgical team in a private hospital. Causes of stricture were trauma 26(24.1%), infection 58(53.7%), catheter induced 8(7.4%), post TURP 11(10.2%) and unknown 5(4.6%). Oral mucous membrane was harvested from the cheek or from the inner side of lower lip. Defect of the urethra displayed by longitudinal ventral urethrotomy and the graft was sutured over the edges of the incised urethral mucosa over a 14 Fr latex Foley's catheter. Spongiosum tissue was closed over the graft. Pericatheter urethrogram was performed in all cases to check for the anastomotic leakage and the Catheter was removed after 2 weeks of the procedure. After removal of catheter uroflowmetry & ultrasound scan of bladder were performed to estimate the maximum flow rate and post voidal residue. The patient was followed-up every 3 months with uroflowmetry & ultrasonography. The median (range) age of the patients was 32(21-72) years. Mean follow up period was 36 months (range 12-54). Mean ± SD stricture length was 3.7 ± 2.6 cm. The overall success rate was 91.7%. Mean ± SD flow rate was 23 ± 4.2 ml/sec, mean ± SD post void residue was 25 ± 15.5 ml and patient quality of life (QOL) was excellent in almost all patients. Overall complications were seen in 9(8.3%) cases. Of which, restricture occurred in 6 patients; periurethral fistulae seen in 2 cases and per urethral bleeding in 1 patient. No significant complications were observed at the donor site. Oral numbness and mild discomfort complained by 67.6% patients which were managed by reassurance only. In our experience ventral placement of oral mucous membrane graft along with spongioplasty is a very easy procedure with very encouraging short term result.
[Mh] Términos MeSH primario: Colgajos Tisulares Libres
Mucosa Bucal/trasplante
Estrechez Uretral/cirugía
[Mh] Términos MeSH secundario: Adulto
Anciano
Humanos
Masculino
Mediana Edad
Complicaciones Postoperatorias
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1304
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:121108
[St] Status:MEDLINE


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[PMID]:22954770
[Au] Autor:Khor R; Duchesne G; Tai KH; Foroudi F; Chander S; Van Dyk S; Garth M; Williams S
[Ad] Dirección:Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, and University of Melbourne, Melbourne, Australia.
[Ti] Título:Direct 2-arm comparison shows benefit of high-dose-rate brachytherapy boost vs external beam radiation therapy alone for prostate cancer.
[So] Fuente:Int J Radiat Oncol Biol Phys;85(3):679-85, 2013 Mar 1.
[Is] ISSN:1879-355X
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:PURPOSE: To evaluate the outcomes of patients treated for intermediate- and high-risk prostate cancer with a single schedule of either external beam radiation therapy (EBRT) and high-dose-rate brachytherapy (HDRB) boost or EBRT alone. METHODS AND MATERIALS: From 2001-2006, 344 patients received EBRT with HDRB boost for definitive treatment of intermediate- or high-risk prostate cancer. The prescribed EBRT dose was 46 Gy in 23 fractions, with a HDR boost of 19.5 Gy in 3 fractions. This cohort was compared to a contemporaneously treated cohort who received EBRT to 74 Gy in 37 fractions, using a matched pair analysis. Three-dimensional conformal EBRT was used. Matching was performed using a propensity score matching technique. High-risk patients constituted 41% of the matched cohorts. Five-year clinical and biochemical outcomes were analyzed. RESULTS: Initial significant differences in prognostic indicators between the unmatched treatment cohorts were rendered negligible after matching, providing a total of 688 patients. Median biochemical follow-up was 60.5 months. The 5-year freedom from biochemical failure was 79.8% (95% confidence interval [CI], 74.3%-85.0%) and 70.9% (95% CI, 65.4%-76.0%) for the HDRB and EBRT groups, respectively, equating to a hazard ratio of 0.59 (95% CI, 0.43-0.81, P=.0011). Interaction analyses showed no alteration in HDR efficacy when planned androgen deprivation therapy was administered (P=.95), but a strong trend toward reduced efficacy was shown compared to EBRT in high-risk cases (P=.06). Rates of grade 3 urethral stricture were 0.3% (95% CI, 0%-0.9%) and 11.8% (95% CI, 8.1%-16.5%) for EBRT and HDRB, respectively (P<.0001). No differences in clinical outcomes were observed. CONCLUSIONS: This comparison of 2 individual contemporaneously treated HDRB and EBRT approaches showed improved freedom from biochemical progression with the HDR approach. The benefit was more pronounced in intermediate- risk patients but needs to be weighed against an increased risk of urethral toxicity.
[Mh] Términos MeSH primario: Braquiterapia/métodos
Neoplasias de la Próstata/radioterapia
Radioterapia Conformal/métodos
[Mh] Términos MeSH secundario: Anciano
Antagonistas de Andrógenos/uso terapéutico
Antineoplásicos Hormonales/uso terapéutico
Braquiterapia/efectos adversos
Estudios de Cohortes
Humanos
Masculino
Análisis por Apareamiento
Mediana Edad
Antígeno Prostático Específico/sangre
Neoplasias de la Próstata/sangre
Neoplasias de la Próstata/quimioterapia
Dosificación Radioterapéutica
Radioterapia Conformal/efectos adversos
Estrechez Uretral/etiología
[Pt] Tipo de publicación:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Androgen Antagonists); 0 (Antineoplastic Agents, Hormonal); EC 3.4.21.77 (Prostate-Specific Antigen)
[Em] Mes de ingreso:1303
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:130204
[St] Status:MEDLINE



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