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[PMID]: 29329570 [Au] Autor: Erdei A; Steiber Z; Molnar C; Berenyi E; Nagy EV [Ad] Dirección: Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt 98, Debrecen, 4032, Hungary. erdeianm@gmail.com. [Ti] Título: Exophthalmos in a young woman with no graves' disease - a case report of IgG4-related orbitopathy. [So] Fuente: BMC Ophthalmol;18(1):5, 2018 Jan 12. [Is] ISSN: 1471-2415 [Cp] País de publicación: England [La] Idioma: eng [Ab] Resumen: BACKGROUND: Immunoglobulin G4-related disease (IgG4-rd) is characterized by lymphoplasmacytic infiltration and tissue fibrosis. Orbital manifestations of IgG4-rd may include unilateral or bilateral proptosis, cicatricial extraocular muscle myopathy, orbital inflammation and pain which may mimic ophthalmic Graves' disease. CASE PRESENTATION: A 25-year-old woman has been referred to the endocrinology clinic, 4 months after delivery, with suspected Graves' orbitopathy. She has had bronchial asthma and recurrent skin rashes of unknown aetiology for the last 10 years and was treated for dacryoadenitis with steroid containing eye drops 5 years ago. During pregnancy she developed eyelid swelling. After delivery, eyelid redness and retrobulbar pain evolved. Proptosis was demonstrated by Hertel's exophthalmometry. Orbital magnetic resonance imaging showed enlarged lateral and superior rectus muscles in both orbits. Thyroid function tests were in the normal range and no thyroid stimulating hormone (TSH) receptor autoantibodies were present. The eye muscle involvement pattern raised suspicion, and the high IgG4 level with positive histology of the lacrimal gland confirmed the diagnosis of immunoglobulin G4-related orbitopathy. Rapid improvement was observed following oral methylprednisolone. CONCLUSIONS: IgG4-related orbitopathy may mimic Graves' orbitopathy. Euthyroid patients with no TSH receptor autoantibodies should be evaluated for immunoglobulin G4-related orbitopathy. Once IgG4-related orbitopathy is proven, other manifestations of IgG4-related disease have to be searched for; lifelong follow-up is warranted. [Mh] Términos MeSH primario: Anticuerpos Antiidiotipos/inmunología Autoanticuerpos/inmunología Enfermedades Autoinmunes/complicaciones Exoftalmia/etiología Músculos Oculomotores/diagnóstico por imagen [Mh] Términos MeSH secundario: Adulto Enfermedades Autoinmunes/diagnóstico Enfermedades Autoinmunes/inmunología Diagnóstico Diferencial Exoftalmia/diagnóstico Exoftalmia/inmunología Femenino Oftalmopatía de Graves Seres Humanos Imagen por Resonancia Magnética Órbita [Pt] Tipo de publicación: JOURNAL ARTICLE [Nm] Nombre de substancia: 0 (Antibodies, Anti-Idiotypic); 0 (Autoantibodies); 0 (anti-IgA) [Em] Mes de ingreso: 1803 [Cu] Fecha actualización por clase: 180305 [Lr] Fecha última revisión: 180305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 180114 [St] Status: MEDLINE [do] DOI: 10.1186/s12886-018-0672-y

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[PMID]: 28746252 [Au] Autor: Thyparampil PJ; Yen MT; Dhingra S; Shetlar DJ; Zarrin-Khameh N; Musher BL [Ti] Título: Primary Neuroendocrine Tumor of the Orbit Presenting With Acute Proptosis. [So] Fuente: Ophthal Plast Reconstr Surg;34(1):e17-e19, 2018 Jan/Feb. [Is] ISSN: 1537-2677 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: Primary neuroendocrine tumors of the orbit are exceedingly rare and typically present with gradual, progressive exophthalmos. In this report, an otherwise healthy 64-year-old woman undergoes resection of a well-differentiated neuroendocrine tumor after presenting with acute proptosis. An extensive clinical and radiographic evaluation reveals no other evidence of disease, establishing the diagnosis of a primary neuroendocrine tumor. The case presentation is followed by a brief review of the classification, presentation, and evaluation of orbital neuroendocrine tumors. [Mh] Términos MeSH primario: Exoftalmia/etiología Tumores Neuroendocrinos/complicaciones Órbita/diagnóstico por imagen Neoplasias Orbitales/complicaciones [Mh] Términos MeSH secundario: Enfermedad Aguda Exoftalmia/diagnóstico Exoftalmia/cirugía Seres Humanos Masculino Mediana Edad Tumores Neuroendocrinos/diagnóstico Tumores Neuroendocrinos/cirugía Procedimientos Quirúrgicos Oftalmológicos/métodos Órbita/cirugía Neoplasias Orbitales/diagnóstico Neoplasias Orbitales/cirugía Tomografía Computarizada por Rayos X [Pt] Tipo de publicación: CASE REPORTS; JOURNAL ARTICLE [Em] Mes de ingreso: 1802 [Cu] Fecha actualización por clase: 180219 [Lr] Fecha última revisión: 180219 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 170727 [St] Status: MEDLINE [do] DOI: 10.1097/IOP.0000000000000968

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[PMID]: 29230267 [Au] Autor: Shifa JZ; Gezmu AM [Ad] Dirección: Department of Surgery, Faculty of Medicine, University of Botswana, Gaborone, Botswana. [Ti] Título: Presenting signs of retinoblastoma at a tertiary level teaching hospital in Ethiopia. [So] Fuente: Pan Afr Med J;28:66, 2017. [Is] ISSN: 1937-8688 [Cp] País de publicación: Uganda [La] Idioma: eng [Ab] Resumen: Introduction: Retinoblastoma is a primary malignant intraocular neoplasm that arise from immature retinoblasts with in developing retina. The commonest presenting sign in developing country is proptosis which is the late presenting sign. We report presenting signs of retinoblastoma in Ethiopian children seen at a tertiary level teaching hospitals in Ethiopia. Methods: Prospective case series study was done on children who presented with retinoblastoma between May 1, 2005 and September 1, 2006. This study was done as part of requirement for partial fulfilment of certificate of specialty study in ophthalmology during the year 2005 to 2006. SPSS 11 statistical package was used to analyse the data. Results: Among 41 patients seen during the study period, 24 (58.5%) were males and 17(41%) were females. Unilateral retinoblastoma was found in 32 (78%) patients and bilateral cases were found in 9(22%). Mean age of onset for right eye was 27.5 months and left eye 33.7 months. The mean ages of presentation at time of diagnosis for right and left eye were 34.4 and 40.2 months, respectively .In bilateral retinoblastoma mean age of presentation was 33.3 months. The commonest presenting sign was proptosis 22(53.7%) followed by leucocorea nine (22%),ocular inflammation four (9.0 %), strabismus three (7.3%), glaucoma one (2.4%), loss of vision one (2.4%)and hyphemaone (2.4%). Conclusion: The commonest presenting signs of retinoblastoma in our set up were Proptosis followed by leucocorea. This is due to late presentation of patient and late referral by medical professionals. Health education to the public and health professionals will help early detection of retinoblastoma. [Mh] Términos MeSH primario: Exoftalmia/etiología Neoplasias de la Retina/diagnóstico Retinoblastoma/diagnóstico [Mh] Términos MeSH secundario: Edad de Inicio Preescolar Detección Precóz del Cáncer Etiopía Exoftalmia/epidemiología Femenino Hospitales de Enseñanza Seres Humanos Masculino Estudios Prospectivos Derivación y Consulta Neoplasias de la Retina/epidemiología Neoplasias de la Retina/patología Retinoblastoma/epidemiología Retinoblastoma/patología Estrabismo/epidemiología Estrabismo/etiología [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1712 [Cu] Fecha actualización por clase: 171222 [Lr] Fecha última revisión: 171222 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 171213 [St] Status: MEDLINE [do] DOI: 10.11604/pamj.2017.28.66.11199

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[PMID]: 29187926 [Au] Autor: Daldoul N; Knani L; Gatfaoui F; Mahjoub H [Ad] Dirección: Service d'Ophtalmologie, CHU Farhat Hached, Sousse, Tunisie. [Ti] Título: [Management of moderate and severe dysthyroid orbitopathy: about 22 cases]. [Ti] Título: Prise en charge des orbitopathies dysthyroidiennes modérées et sévères: à propos de 22 cas.. [So] Fuente: Pan Afr Med J;27:257, 2017. [Is] ISSN: 1937-8688 [Cp] País de publicación: Uganda [La] Idioma: fre [Ab] Resumen: Our study aimed to describe the therapeutic management of moderate and severe dysthyroid orbitopathies and to evaluate the factors associated with optic neuropathy as well as the prognostic factors of poor visual outcome using a statistical analysis. We conducted a retrospective study of 22 patients presenting with moderate to severe dysthyroid orbitopathy in at least one eye and hospitalized in the Department of Ophthalmology at the University Hospital Farhat Hached, Sousse over the period from 1998 to 2015. Therapeutic indications were based on activity and severity criteria of the Eugogo (European Group On Graves' Orbitopathy) as well as on the assessment of prognostic factors of poor visual outcome. The average age of our patients was 40 years, with a slight male predominance (54.5%). 68.2% of patients were euthyroid, 18.2% had a history of smoking. The most significantly associated factor with neuropathy was a compression in the orbital apex (p = 0.03). Treatment was based on intravenous corticosteroid therapy and/or orbital decompression based on disease activity and severity. Overall evolution after treatment was marked by an improvement in inflammatory signs and by the reduction of exophthalmia. Visual prognosis was worse in elderly patients (p = 0.0001), male sex (p = 0.03) and treated by iratherapy (p = 0.04). Given the limits of a retrospective study, our results were generally consistent with the literature. The assessment and the management of dysthyroid orbitopathy are not well understood. Cohort, probably multicenter studies should be conducted to improve its management. [Mh] Términos MeSH primario: Exoftalmia/terapia Oftalmopatía de Graves/terapia Enfermedades del Nervio Óptico/terapia [Mh] Términos MeSH secundario: Administración Intravenosa Corticoesteroides/administración & dosificación Adulto Factores de Edad Anciano Descompresión Quirúrgica/métodos Exoftalmia/etiología Femenino Seres Humanos Masculino Mediana Edad Enfermedades del Nervio Óptico/etiología Pronóstico Estudios Retrospectivos Índice de Severidad de la Enfermedad Resultado del Tratamiento Túnez [Pt] Tipo de publicación: JOURNAL ARTICLE [Nm] Nombre de substancia: 0 (Adrenal Cortex Hormones) [Em] Mes de ingreso: 1712 [Cu] Fecha actualización por clase: 171219 [Lr] Fecha última revisión: 171219 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 171201 [St] Status: MEDLINE [do] DOI: 10.11604/pamj.2017.27.257.13008

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[PMID]: 28467880 [Au] Autor: Smith TJ; Kahaly GJ; Ezra DG; Fleming JC; Dailey RA; Tang RA; Harris GJ; Antonelli A; Salvi M; Goldberg RA; Gigantelli JW; Couch SM; Shriver EM; Hayek BR; Hink EM; Woodward RM; Gabriel K; Magni G; Douglas RS [Ad] Dirección: From the Department of Ophthalmology and Visual Sciences, Kellogg Eye Center (T.J.S., R.S.D.), and the Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine (T.J.S.), University of Michigan Medical School, Ann Arbor; the Department of Medicine, Johannes Gutenberg Unive [Ti] Título: Teprotumumab for Thyroid-Associated Ophthalmopathy. [So] Fuente: N Engl J Med;376(18):1748-1761, 2017 05 04. [Is] ISSN: 1533-4406 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: BACKGROUND: Thyroid-associated ophthalmopathy, a condition commonly associated with Graves' disease, remains inadequately treated. Current medical therapies, which primarily consist of glucocorticoids, have limited efficacy and present safety concerns. Inhibition of the insulin-like growth factor I receptor (IGF-IR) is a new therapeutic strategy to attenuate the underlying autoimmune pathogenesis of ophthalmopathy. METHODS: We conducted a multicenter, double-masked, randomized, placebo-controlled trial to determine the efficacy and safety of teprotumumab, a human monoclonal antibody inhibitor of IGF-IR, in patients with active, moderate-to-severe ophthalmopathy. A total of 88 patients were randomly assigned to receive placebo or active drug administered intravenously once every 3 weeks for a total of eight infusions. The primary end point was the response in the study eye. This response was defined as a reduction of 2 points or more in the Clinical Activity Score (scores range from 0 to 7, with a score of ≥3 indicating active thyroid-associated ophthalmopathy) and a reduction of 2 mm or more in proptosis at week 24. Secondary end points, measured as continuous variables, included proptosis, the Clinical Activity Score, and results on the Graves' ophthalmopathy-specific quality-of-life questionnaire. Adverse events were assessed. RESULTS: In the intention-to-treat population, 29 of 42 patients who received teprotumumab (69%), as compared with 9 of 45 patients who received placebo (20%), had a response at week 24 (P<0.001). Therapeutic effects were rapid; at week 6, a total of 18 of 42 patients in the teprotumumab group (43%) and 2 of 45 patients in the placebo group (4%) had a response (P<0.001). Differences between the groups increased at subsequent time points. The only drug-related adverse event was hyperglycemia in patients with diabetes; this event was controlled by adjusting medication for diabetes. CONCLUSIONS: In patients with active ophthalmopathy, teprotumumab was more effective than placebo in reducing proptosis and the Clinical Activity Score. (Funded by River Vision Development and others; ClinicalTrials.gov number, NCT01868997 .). [Mh] Términos MeSH primario: Anticuerpos Monoclonales/uso terapéutico Oftalmopatía de Graves/tratamiento farmacológico Factores Inmunológicos/uso terapéutico Factor I del Crecimiento Similar a la Insulina/antagonistas & inhibidores [Mh] Términos MeSH secundario: Adulto Anciano Anticuerpos Monoclonales/efectos adversos Complicaciones de la Diabetes Método Doble Ciego Exoftalmia/tratamiento farmacológico Femenino Oftalmopatía de Graves/complicaciones Seres Humanos Hiperglucemia/inducido químicamente Factores Inmunológicos/efectos adversos Análisis de Intención de Tratar Modelos Logísticos Masculino Mediana Edad Calidad de Vida [Pt] Tipo de publicación: JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL [Nm] Nombre de substancia: 0 (Antibodies, Monoclonal); 0 (Immunologic Factors); 0 (R-1507 monoclonal antibody); 67763-96-6 (Insulin-Like Growth Factor I) [Em] Mes de ingreso: 1705 [Cu] Fecha actualización por clase: 171208 [Lr] Fecha última revisión: 171208 [Sb] Subgrupo de revista: AIM; IM [Da] Fecha de ingreso para procesamiento: 170504 [Cl] Clinical Trial: ClinicalTrial [St] Status: MEDLINE [do] DOI: 10.1056/NEJMoa1614949

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[PMID]: 28819512 [Au] Autor: Belhachmi A [Ad] Dirección: Service de Neurochirurgie et Neuroradiologie Interventionnelle, Hôpital Chekh Zaid Hay Riad, Rabat, Maroc. [Ti] Título: [Spontaneous bilateral carotid-cavernous fistulas: about a case and review of the literature]. [Ti] Título: Fistules carotido-caverneuses bilatérales spontanées: à propos d'un cas et revue de la littérature.. [So] Fuente: Pan Afr Med J;27:91, 2017. [Is] ISSN: 1937-8688 [Cp] País de publicación: Uganda [La] Idioma: fre [Ab] Resumen: We report a clinical case of spontaneous bilateral carotid-cavernous fistulas. Bilateral pulsatile exophthalmos and symmetric cavernous sinuses detected by CT scan helped to suspect the diagnosis. Arteriography confirmed the diagnosis. The patient underwent embolization with favorable neurologic and ophthalmic evolution. Carotid-cavernous fistula is a rare but severe complication associated with a poor functional (blindness) and vital (meningeal and intracerebral hemorrhage) prognosis. The concomitant use of arteriography and embolization has considerably improved the prognosis. [Mh] Términos MeSH primario: Fístula del Seno Cavernoso de la Carótida/terapia Embolización Terapéutica/métodos Exoftalmia/etiología [Mh] Términos MeSH secundario: Angiografía/métodos Fístula del Seno Cavernoso de la Carótida/diagnóstico por imagen Seno Cavernoso/diagnóstico por imagen Femenino Seres Humanos Pronóstico Tomografía Computarizada por Rayos X/métodos Adulto Joven [Pt] Tipo de publicación: CASE REPORTS; JOURNAL ARTICLE; REVIEW [Em] Mes de ingreso: 1709 [Cu] Fecha actualización por clase: 170904 [Lr] Fecha última revisión: 170904 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 170819 [St] Status: MEDLINE [do] DOI: 10.11604/pamj.2017.27.91.8594

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[PMID]: 28606263 [Au] Autor: Guo J; Qian J; Li XF; Meng FX; Ma RQ [Ad] Dirección: Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Myopia Key Laboratory of Health Ministry, Shanghai 200031, China. [Ti] Título: [Three-dimensional vector analysis after decompression surgery in thyroid-associated ophthalmopathy]. [So] Fuente: Zhonghua Yan Ke Za Zhi;53(6):424-429, 2017 Jun 11. [Is] ISSN: 0412-4081 [Cp] País de publicación: China [La] Idioma: chi [Ab] Resumen: To analyze the change of globe position after different orbital decompression in thyroid-associated ophthalmopathy (TAO). It was a retrosective case series study. Twenty-nine TAO patients (33 eyes) underwent orbital decompression were collected between October 2014 and December 2016 at Eye & ENT Hospital of Fudan University. There were 17 males and 12 females, and the average age was 46 years (ranging from 21 to 66 years). Fifteen patients (17 eyes) underwent balanced decompression, 11 patients (11 eyes) underwent deep lateral decompression, and 4 patients (5 eyes) underwent medial decompression. CT scan was performed pre and postoperatively for each patient and a reference coordinate system was established on the three-dimensional reconstructed image. The eyeball vector EC from the eyeball center to the corneal apex was defined and the coordinates (X(E), Y(E), Z(E))(X(C), Y(C), Z(C)) were calculated. The angle M between EC and the midsagittal plane and the angle F between EC and the Frankfort plane were also calculated. Paired test and one way ANOVA were used for statistical analysis. The average value of X(C) before and after deep lateral decompression was 19.53 mm and 17.25 mm ( 10.87, 0.05) and average value of X(E) was 7.73 mm and 5.69 mm ( 12.22, 0.05). The average value of X(C) before and after medial decompression was 20.24 mm and 18.17 mm ( 7.93, 0.05) and average value of X(E) was 7.14 mm and 5.52 mm ( 9.24, 0.05). The average value of X(C) before and after balanced decompression was 22.16 mm and 18.83 mm ( 12.71 , 0.05) and average value of X(E) was 10.20 mm and 6.67 mm ( 11.91, 0.05). The average value of horizontal deviation angle M before and after medial decompression was 6.48° and 13.34° ( 8.41, 0.05). The average value of angle M before and after balanced decompression was 1.42° and 6.76° ( 2.86, 0.05). The average value of angle M before and after deep lateral decompression was 5.18° and 1.39° ( 2.57, 0.05). The proptosis reduction was significant after deep lateral decompression, balanced decompression and medial decompression. Additionally, the horizontal deviation tended to increase after medial and balanced decompression, whereas the horizaontal deviation tended to decrease after deep lateral decompression. . [Mh] Términos MeSH primario: Descompresión Quirúrgica/métodos Oftalmopatía de Graves/cirugía Órbita/cirugía [Mh] Términos MeSH secundario: Adulto Anciano Análisis de Varianza Exoftalmia/cirugía Femenino Oftalmopatía de Graves/diagnóstico por imagen Oftalmopatía de Graves/patología Seres Humanos Imagen Tridimensional Masculino Mediana Edad Periodo Posoperatorio Estudios Retrospectivos Tomografía Computarizada por Rayos X Resultado del Tratamiento [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1709 [Cu] Fecha actualización por clase: 170906 [Lr] Fecha última revisión: 170906 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 170614 [St] Status: MEDLINE [do] DOI: 10.3760/cma.j.issn.0412-4081.2017.06.006

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[PMID]: 28533854 [Au] Autor: Saqui AE; Aggouri M; Benzagmout M; Chakour K; Chaoui MEF [Ad] Dirección: Service Neurochirurgie, CHU Hassan II, Fès, Maroc. [Ti] Título: [A rare cause of exophthalmia: intraorbital cavernous hemangioma (about a case)]. [Ti] Título: Une cause rare d'exophtalmie: l'hémangiome caverneux intraorbitaire (à propos d'un cas).. [So] Fuente: Pan Afr Med J;26:131, 2017. [Is] ISSN: 1937-8688 [Cp] País de publicación: Uganda [La] Idioma: fre [Ab] Resumen: Cavernous hemangioma is the most frequent primary benign vascular tumor of the orbit in the adult; the median age of diagnosis is 42 years with a female predominance. This tumor develops slowly and has no tendency for spontaneous regression; it is electively located at the level of the retro-ocular muscular cone but it can develop in the extraconic space. Clinically it appears as progressive irreducible, non-pulsating, painless (unless there's an unexpected complication) exophthalmia, associated with decrease in visual acuity in 2/3 of cases. The diagnosis is easily confirmed by imaging, which allows to precisely locate the tumor in relation to the optic nerve and the oculomotor muscles and to indicate the type of surgical approach. Surgical resection should be complete; it is usually simple because the tumor is limited and perfectly cleavable. Surgical approach is established on the basis of tumor volume and above all of the seat of the lesion. Functional prognosis is good and recurrences are rare. We here report the case of a 44-year old patient with orbital cavernous hemangioma revealed by exophthalmia. [Mh] Términos MeSH primario: Exoftalmia/etiología Hemangioma Cavernoso/complicaciones Neoplasias Orbitales/complicaciones [Mh] Términos MeSH secundario: Adulto Hemangioma Cavernoso/diagnóstico Hemangioma Cavernoso/patología Seres Humanos Masculino Nervio Óptico/patología Neoplasias Orbitales/diagnóstico Neoplasias Orbitales/patología Pronóstico Carga Tumoral [Pt] Tipo de publicación: CASE REPORTS; JOURNAL ARTICLE [Em] Mes de ingreso: 1706 [Cu] Fecha actualización por clase: 170613 [Lr] Fecha última revisión: 170613 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 170524 [St] Status: MEDLINE [do] DOI: 10.11604/pamj.2017.26.131.9808

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[PMID]: 28388343 [Au] Autor: Lorenzano D; Miszkiel K; Rose GE [Ad] Dirección: a Adnexal Service , Moorfields Eye Hospital NHS Foundation Trust , London , United Kingdom. [Ti] Título: Orbital melanoma masquerading as a "Galloping haemangioma". [So] Fuente: Orbit;36(2):81-83, 2017 Apr. [Is] ISSN: 1744-5108 [Cp] País de publicación: England [La] Idioma: eng [Ab] Resumen: We describe a 32-year-old pregnant woman who was referred to our clinic after 6 weeks of observation elsewhere with a rapidly expanding orbital mass, proptosed globe and slowly decreasing of vision in her left eye. To our examination the patient presented with congested optic disc fine macular striae and some slight choroidal elevation without any retinal pigmentation. An MRI scan without contrast was performed, suggesting the signal charactheristics of an orbital mass consistent with a cellular lesion such as a cavernous hemangioma or a solitary fibrous tumour. Despite the benign-looking imaging, the fast-growing pattern of the lesion suggested a more sinister picture. A fine needle aspiration of the orbital mass was carried out, revealing the presence of an amelanotic melanoma. This case highlights the importance of considering the presence of a melanoma when there is a clear history of a rapid lesion progression. [Mh] Términos MeSH primario: Hemangioma/diagnóstico Melanoma Amelanótico/diagnóstico Neoplasias Orbitales/diagnóstico Complicaciones Neoplásicas del Embarazo [Mh] Términos MeSH secundario: Adulto Biopsia con Aguja Fina Diagnóstico Diferencial Fraccionamiento de la Dosis Exoftalmia/diagnóstico Femenino Seres Humanos Imagen por Resonancia Magnética Melanoma Amelanótico/radioterapia Neoplasias Orbitales/radioterapia Tomografía de Emisión de Positrones Embarazo Dosis de Radiación Tomografía Computarizada por Rayos X [Pt] Tipo de publicación: CASE REPORTS; JOURNAL ARTICLE [Em] Mes de ingreso: 1710 [Cu] Fecha actualización por clase: 171006 [Lr] Fecha última revisión: 171006 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 170408 [St] Status: MEDLINE [do] DOI: 10.1080/01676830.2017.1279657

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[PMID]: 28364526 [Au] Autor: Taban MR [Ad] Dirección: Division of Orbital and Ophthalmic Plastic Surgery, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA. [Ti] Título: Expanding Role of Orbital Decompression in Aesthetic Surgery. [So] Fuente: Aesthet Surg J;37(4):389-395, 2017 04 01. [Is] ISSN: 1527-330X [Cp] País de publicación: England [La] Idioma: eng [Ab] Resumen: Background: Eye prominence is a source of cosmetic "deformity" for many patients not afflicted by Graves. Objectives: To report our experience in using customized orbital decompression for purely aesthetic reason to reduce eye prominence in non-thyroid patients. Methods: Retrospective analysis of patients undergoing cosmetic orbital decompression by one surgeon. Surgical technique included customized graded orbital bony-wall decompression (lateral-wall, basin, medial-wall, posterior-strut) and intraconal fat removal using eyelid crease and/or caruncle incisions. Inclusion criteria included any patient with relative prominent eye due to non-thyroid etiology. Preoperative and postoperative photographs at longest follow-up were used for analysis. Outcome measures included patient satisfaction (via a written questionnaire) and complication rates. Results: Etiologies of prominent eyes included congenital shallow orbits (14), congenital hypoplasia of malar-eminence (5), enlarged globe from high myopia (5), buphthalmos (1), and relative proptosis from contralateral enophthalmos (1). Concurrent procedures included lower eyelid-retractors lysis (5), periocular fat injection (3), tear-trough implant (3), canthoplasty (3), and periocular filler injection (3). Mean patient age was 33.8 years (range, 19-60 years). The average follow-up was 9 months (range, 6 months-4 years). All 26 patients (11 males, 15 females) had reduction in globe prominence. The mean reduction in axial globe position was 3.1 mm (range, 1.5-6.2 mm). Twenty-four of 26 patients were satisfied with the surgical outcome, with 2 patients complaining of sunken eyes. No case of permanent diplopia occurred. Conclusions: Orbital decompression may be done for cosmetic purpose, effectively and safely, to reduce eye prominence in non-thyroid patients by an experienced orbital surgeon. Level of Evidence: 4. [Mh] Términos MeSH primario: Técnicas Cosméticas Descompresión Quirúrgica/métodos Exoftalmia/cirugía Anomalías del Ojo/cirugía Órbita/cirugía [Mh] Términos MeSH secundario: Tejido Adiposo/cirugía Adulto Párpados/cirugía Femenino Estudios de Seguimiento Seres Humanos Masculino Mediana Edad Satisfacción del Paciente Complicaciones Posoperatorias/epidemiología Estudios Retrospectivos Encuestas y Cuestionarios Resultado del Tratamiento Adulto Joven [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1706 [Cu] Fecha actualización por clase: 170825 [Lr] Fecha última revisión: 170825 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 170402 [St] Status: MEDLINE [do] DOI: 10.1093/asj/sjw248

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1			PalabrasDescriptor de asuntoDescriptor de asunto primarioLímitesAutorPalabras del títuloPalabras del resumenIdiomaPaís de publicaciónNombre de substanciaNombre personal como asuntoRevistaAsunto de RevistaISSNTipo de publicaciónIdentificador únicoMes de ingresoAño de publicaciónTexto completoActualización por claseCategoria DeCSCategoria DeCS explodidaCategoria CIE-10SubSetsPaís de AfiliaciónAfiliaciónAfiliación 2
2	and or and not		PalabrasDescriptor de asuntoDescriptor de asunto primarioLímitesAutorPalabras del títuloPalabras del resumenIdiomaPaís de publicaciónNombre de substanciaNombre personal como asuntoRevistaAsunto de RevistaISSNTipo de publicaciónIdentificador únicoMes de ingresoAño de publicaciónTexto completoActualización por claseCategoria DeCSCategoria DeCS explodidaCategoria CIE-10SubSetsPaís de AfiliaciónAfiliaciónAfiliación 2
3	and or and not		PalabrasDescriptor de asuntoDescriptor de asunto primarioLímitesAutorPalabras del títuloPalabras del resumenIdiomaPaís de publicaciónNombre de substanciaNombre personal como asuntoRevistaAsunto de RevistaISSNTipo de publicaciónIdentificador únicoMes de ingresoAño de publicaciónTexto completoActualización por claseCategoria DeCSCategoria DeCS explodidaCategoria CIE-10SubSetsPaís de AfiliaciónAfiliaciónAfiliación 2

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