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[PMID]: 23185235 [Au] Autor: Adonin LS; Shaposhnikova TG; Podgornaya O [Ad] Dirección: Institute of Cytology RAS, St. Petersburg, Russia. [Ti] Título: Aurelia aurita (Cnidaria) oocytes' contact plate structure and development. [So] Fuente: PLoS One;7(11):e46542, 2012. [Is] ISSN: 1932-6203 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: One of the A. aurita medusa main mesoglea polypeptides, mesoglein, has been described previously. Mesoglein belongs to ZP-domain protein family and therefore we focused on A.aurita oogenesis. Antibodies against mesoglein (AB RA47) stain the plate in the place where germinal epithelium contacts oocyte on the paraffin sections. According to its position, we named the structure found the "contact plate". Our main instrument was AB against mesoglein. ZP-domain occupies about half of the whole amino acid sequence of the mesoglein. Immunoblot after SDS-PAGE and AU-PAGE reveals two charged and high M(r) bands among the female gonad germinal epithelium polypeptides. One of the gonads' polypeptides M(r) corresponds to that of mesogleal cells, the other ones' M(r) is higher. The morphological description of contact plate formation is the subject of the current work. Two types of AB RA47 positive granules were observed during progressive oogenesis stages. Granules form the contact plate in mature oocyte. Contact plate of A.aurita oocyte marks its animal pole and resembles Zona Pellucida by the following features: (1) it attracts spermatozoids; (2) the material of the contact plate is synthesized by oocyte and stored in granules; (3) these granules and the contact plate itself contain ZP domain protein(s); (4) contact plate is an extracellular structure made up of fiber bundles similar to those of conventional Zona Pellucida. [Mh] Términos MeSH primario: Oocitos/citología Oocitos/crecimiento & desarrollo Escifozoos/citología Escifozoos/crecimiento & desarrollo [Mh] Términos MeSH secundario: Animales Electroforesis Femenino Fertilización In Vitro Técnica del Anticuerpo Fluorescente Gónadas/citología Gónadas/ultraestructura Immunoblotting Oocitos/metabolismo Oocitos/ultraestructura Colorantes de Rosanilina/metabolismo Escifozoos/ultraestructura [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (Rosaniline Dyes) [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 121127 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0046542

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[PMID]: 22964562 [Au] Autor: Janner M; Flück CE; Mullis PE [Ad] Dirección: Pediatric Endocrinology, Diabetology and Metabolism, University Children's Hospital, Inselspital, Bern, Switzerland. marco.janner @ insel.ch [Ti] Título: Impact of estrogen replacement throughout childhood on growth, pituitary-gonadal axis and bone in a 46,XX patient with CYP19A1 deficiency. [So] Fuente: Horm Res Paediatr;78(4):261-8, 2012. [Is] ISSN: 1663-2826 [Cp] País de publicación: Switzerland [La] Idioma: eng [Ab] Resumen: BACKGROUND: The adequate replacement dose of estrogens during infancy and childhood is still not known in girls. Aromatase deficiency offers an excellent model to study how much estrogens are needed during infancy, childhood and adulthood. OBJECTIVES: We studied the impact of oral 17ß-estradiol treatment, on longitudinal growth, bone age maturation, pituitary gonadotropin feedback, multicystic ovaries and bone mass in the long-term follow-up of a girl compound heterozygote for two point mutations of the CYP19A1 gene. RESULTS: Low doses of 17ß-estradiol were needed to achieve normal height velocity and adequate bone age maturation from early childhood on. Serum estradiol levels needed for breast development and for the appearance of an endometrial reflex were not sufficient to achieve physiological gonadotropin levels. Without 17ß-estradiol treatment the ovaries of the patient showed a multicystic appearance, which reversed on 17ß-estradiol replacement. Bone mass was within normal ranges during the whole follow-up period. CONCLUSION: In summary, we have shown that estradiol is needed not only in puberty but also in childhood for normal growth, bone maturation and achievement of normal bone mass. Particularly, this observation underscores the importance of early low-dose estrogen replacement also in other estrogen-deficient conditions as for instance in Turner's syndrome. [Mh] Términos MeSH primario: Trastornos del Desarrollo Sexual 46, XX Desarrollo Infantil/efectos de drogas Estradiol/farmacología Estradiol/uso terapéutico Gónadas/efectos de drogas Ginecomastia Infertilidad Masculina Errores Innatos del Metabolismo Hipófisis/efectos de drogas [Mh] Términos MeSH secundario: Trastornos del Desarrollo Sexual 46, XX/quimioterapia Trastornos del Desarrollo Sexual 46, XX/metabolismo Trastornos del Desarrollo Sexual 46, XX/fisiopatología Adolescente Aromatasa/deficiencia Aromatasa/efectos de drogas Aromatasa/genética Aromatasa/metabolismo Desarrollo Óseo/efectos de drogas Huesos/efectos de drogas Huesos/fisiología Niño Preescolar Estradiol/administración & dosificación Terapia de Reemplazo de Estrógeno Femenino Estudios de Seguimiento Gónadas/metabolismo Ginecomastia/metabolismo Ginecomastia/fisiopatología Humanos Infertilidad Masculina/metabolismo Infertilidad Masculina/fisiopatología Errores Innatos del Metabolismo/metabolismo Errores Innatos del Metabolismo/fisiopatología Hipófisis/metabolismo Transducción de Señal/efectos de drogas [Pt] Tipo de publicación: CASE REPORTS; JOURNAL ARTICLE [Nm] Nombre de substancia: 50-28-2 (Estradiol); EC 1.14.14.1 (Aromatase); EC 1.14.14.1 (CYP19A1 protein, human) [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 121127 [St] Status: MEDLINE [do] DOI: 10.1159/000341585

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[PMID]: 23190574 [Au] Autor: Katoh T; Yasuda M; Hasegawa K; Kozawa E; Maniwa J; Sasano H [Ad] Dirección: Department of Pathology, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan. [Ti] Título: Estrogen-producing endometrioid adenocarcinoma resembling sex cord-stromal tumor of the ovary: a review of four postmenopausal cases. [So] Fuente: Diagn Pathol;7:164, 2012. [Is] ISSN: 1746-1596 [Cp] País de publicación: England [La] Idioma: eng [Ab] Resumen: The 4 present cases with endometrioid adenocarcinoma (EMA) of the ovary were characterized by estrogen overproduction and resemblance to sex cord-stromal tumor (SCST). The patients were all postmenopausal, at ages ranging from 60 to 79 years (av. 67.5), who complained of abdominal discomfort or distention and also atypical genital bleeding. Cytologically, maturation of the cervicovaginal squamous epithelium and active endometrial proliferation were detected. The serum estrogen (estradiol, E2) value was preoperatively found to be elevated, ranging from 48.7 to 83.0 pg/mL (av. 58.4). In contrast, follicle stimulating hormone was suppressed to below the normal value. MR imaging diagnoses included SCSTs such as granulosa cell tumor or thecoma for 3 cases because of predominantly solid growth, and epithelial malignancy for one case because of cystic and solid structure. Grossly, the solid part of 3 cases was homogeneously yellow in color. Histologically, varying amounts of tumor components were arranged in solid nests, hollow tubules, cord-like strands and cribriform-like nests in addition to the conventional EMA histology. In summary, postmenopausal ovarian solid tumors with the estrogenic manifestations tend to be preoperatively diagnosed as SCST. Due to this, in the histological diagnosis, this variant of ovarian EMA may be challenging and misdiagnosed as SCST because of its wide range in morphology. [Mh] Términos MeSH primario: Carcinoma Endometrioide/sangre Estradiol/sangre Neoplasias Ováricas/sangre Posmenopausia Tumores de los Cordones Sexuales y Estroma de las Gónadas/sangre Marcadores Biológicos de Tumor/sangre [Mh] Términos MeSH secundario: Anciano Biopsia Carcinoma Endometrioide/patología Carcinoma Endometrioide/terapia Quimioterapia Adyuvante Diagnóstico Diferencial Errores Diagnósticos/prevención & control Femenino Hormona Folículo Estimulante Humana Humanos Histerectomía Inmunohistoquímica Imagen por Resonancia Magnética Mediana Edad Neoplasias Ováricas/patología Neoplasias Ováricas/terapia Valor Predictivo de las Pruebas Tumores de los Cordones Sexuales y Estroma de las Gónadas/patología Resultado del Tratamiento Regulación hacia Arriba [Pt] Tipo de publicación: CASE REPORTS; JOURNAL ARTICLE [Nm] Nombre de substancia: 0 (Follicle Stimulating Hormone, Human); 0 (Tumor Markers, Biological); 50-28-2 (Estradiol) [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 121221 [St] Status: MEDLINE [do] DOI: 10.1186/1746-1596-7-164

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[PMID]: 23271977 [Au] Autor: Anderson C; Zhou S; Sawin E; Horvitz HR; Hurwitz ME [Ad] Dirección: Yale Cancer Center and Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America. [Ti] Título: SLI-1 Cbl inhibits the engulfment of apoptotic cells in C. elegans through a ligase-independent function. [So] Fuente: PLoS Genet;8(12):e1003115, 2012. [Is] ISSN: 1553-7404 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: The engulfment of apoptotic cells is required for normal metazoan development and tissue remodeling. In Caenorhabditis elegans, two parallel and partially redundant conserved pathways act in cell-corpse engulfment. One pathway, which includes the small GTPase CED-10 Rac and the cytoskeletal regulator ABI-1, acts to rearrange the cytoskeleton of the engulfing cell. The CED-10 Rac pathway is also required for proper migration of the distal tip cells (DTCs) during the development of the C. elegans gonad. The second pathway includes the receptor tyrosine kinase CED-1 and might recruit membranes to extend the surface of the engulfing cell. Cbl, the mammalian homolog of the C. elegans E3 ubiquitin ligase and adaptor protein SLI-1, interacts with Rac and Abi2 and modulates the actin cytoskeleton, suggesting it might act in engulfment. Our genetic studies indicate that SLI-1 inhibits apoptotic cell engulfment and DTC migration independently of the CED-10 Rac and CED-1 pathways. We found that the RING finger domain of SLI-1 is not essential to rescue the effects of SLI-1 deletion on cell migration, suggesting that its role in this process is ubiquitin ligase-independent. We propose that SLI-1 opposes the engulfment of apoptotic cells via a previously unidentified pathway. [Mh] Términos MeSH primario: Apoptosis Proteínas de Caenorhabditis elegans Caenorhabditis elegans Movimiento Celular Proteínas Proto-Oncogénicas c-cbl [Mh] Términos MeSH secundario: Citoesqueleto de Actina/genética Citoesqueleto de Actina/metabolismo Animales Caenorhabditis elegans/citología Caenorhabditis elegans/crecimiento & desarrollo Caenorhabditis elegans/metabolismo Proteínas de Caenorhabditis elegans/genética Proteínas de Caenorhabditis elegans/metabolismo Proteínas Citoesqueléticas/genética Proteínas Citoesqueléticas/metabolismo Gónadas/crecimiento & desarrollo Proteínas de la Membrana/genética Proteínas de la Membrana/metabolismo Fagocitosis Proteínas Proto-Oncogénicas c-cbl/genética Proteínas Proto-Oncogénicas c-cbl/metabolismo Transducción de Señal Proteínas de Unión al GTP rac/genética Proteínas de Unión al GTP rac/metabolismo [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (CED-10 protein, C elegans); 0 (Caenorhabditis elegans Proteins); 0 (Cytoskeletal Proteins); 0 (Membrane Proteins); 0 (Sli-1 protein, C elegans); 0 (abi-1 protein, C elegans); 0 (ced-1 protein, C elegans); EC 3.6.5.2 (rac GTP-Binding Proteins); EC 6.3.2.- (Proto-Oncogene Proteins c-cbl) [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 121228 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pgen.1003115

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[PMID]: 23211293 [Au] Autor: D'Angelo E; Ali RH; Espinosa I; Lee CH; Huntsman DG; Gilks B; Prat J [Ad] Dirección: Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institut of Biomedical Research (IIB Sant Pau), Autonomous University of Barcelona, Barcelona, Spain. [Ti] Título: Endometrial stromal sarcomas with sex cord differentiation are associated with PHF1 rearrangement. [So] Fuente: Am J Surg Pathol;37(4):514-21, 2013 Apr. [Is] ISSN: 1532-0979 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: Endometrial stromal tumors may pose diagnostic challenges particularly when they exhibit variant histologic appearances, involve extrauterine sites, or present as metastatic disease. In such cases, use of immunohistochemical markers and identification of specific nonrandom chromosomal rearrangements may be helpful. Over the last decade, fluorescence in situ hybridization (FISH) has been progressively incorporated as a diagnostic tool for the evaluation of endometrial stromal tumors. The purpose of this study was to review a series of these tumors and compare the results of FISH analysis with the clinicopathologic characteristics. Three endometrial stromal nodules (ESNs), 13 endometrial stromal sarcomas (ESSs), and 7 undifferentiated endometrial sarcomas (UESs) were reviewed. Three metastases from 1 of the ESS cases were also analyzed. Nine of these tumors (1 ESN, 8 ESSs, and 1 UES) exhibited unusual histologic features, including smooth muscle (3), sex cord (7), epithelioid (1), fibromyxoid (1), and skeletal muscle (2) differentiation. A tissue microarray was prepared, and FISH analysis was performed using break-apart and fusion probes for JAZF1, SUZ12, EPC1, and PHF1 genes. FISH was successful in 22 cases, and rearrangements involving JAZF1, SUZ12, EPC1, and PHF1 genes were detected in 10 of the 22 (45%) uterine tumors, including 2 of the 3 ESNs and 8 of 12 ESSs. Genetic rearrangements were found neither in the 3 metastases of the ESS nor in any of the UESs. It is noteworthy that a correlation between sex cord differentiation and PHF1 rearrangement was encountered in ESSs (P=0.008). In our series, all ESSs showing sex cords had PHF1 genetic rearrangement, suggesting that such rearrangements may induce sex cord differentiation. [Mh] Términos MeSH primario: Proteínas de Unión al ADN/genética Neoplasias Endometriales/genética Reordenamiento Génico Sarcoma Estromático Endometrial/genética Tumores de los Cordones Sexuales y Estroma de las Gónadas/genética Factores de Transcripción/genética [Mh] Términos MeSH secundario: Adulto Anciano Anciano de 80 o más Años Transformación Celular Neoplásica Terapia Combinada ADN de Neoplasias/análisis Neoplasias Endometriales/patología Neoplasias Endometriales/terapia Femenino Humanos Hibridación Fluorescente In Situ Metástasis Linfática Mediana Edad Estadificación de Neoplasias Sarcoma Estromático Endometrial/secundario Sarcoma Estromático Endometrial/terapia Tumores de los Cordones Sexuales y Estroma de las Gónadas/patología Tumores de los Cordones Sexuales y Estroma de las Gónadas/terapia [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (DNA, Neoplasm); 0 (DNA-Binding Proteins); 0 (PHF1 protein, human); 0 (Transcription Factors) [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 130313 [St] Status: MEDLINE [do] DOI: 10.1097/PAS.0b013e318272c612

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[PMID]: 23151964 [Au] Autor: Wood SA; Casas M; Taylor DI; McNabb P; Salvitti L; Ogilvie S; Cary SC [Ad] Dirección: Cawthron Institute, Nelson, New Zealand, susie.wood@cawthron.org.nz. [Ti] Título: Depuration of tetrodotoxin and changes in bacterial communities in Pleurobranchea maculata adults and egg masses maintained in captivity. [So] Fuente: J Chem Ecol;38(11):1342-50, 2012 Nov. [Is] ISSN: 1573-1561 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: Depuration of tetrodotoxin (TTX) was investigated in adult grey side-gilled sea slugs, Pleurobranchaea maculata, maintained in captivity on a TTX-free diet. Three adults were harvested every 21 days for 126 days, and TTX concentrations were measured in organs/tissues and egg masses. Automated rRNA intergenic spacer analysis (ARISA) was used to investigate bacterial community structure in selected samples. Linear modeling of adult data demonstrated a decline (P<0.001) in average total TTX concentrations over time. Temporal data obtained from a wild population showed similar depuration rates, indicating that once adults reach a certain size, or sexual maturity, TTX is no longer produced or acquired substantially. Depuration rates differed among organs, with concentrations in the heart declining the fastest. The gonads had the slowest and least significant depuration rate indicating, at most, weak depuration of this tissue. There was a strong correlation (R(2)=0.66) between TTX concentrations in the first-laid egg masses and total TTX in the corresponding adult. These data suggest that adult P. maculata transfer TTX to their offspring, and presumably that functions as a chemical defense. ARISA data showed a shift in bacterial community structure within 3 weeks of introduction to captivity. Based on the combined data, the exact origin of TTX in P. maculata is unclear, with evidence both in favor and against a dietary source, and endogenous or bacterial production. [Mh] Términos MeSH primario: Fenómenos Fisiológicos Bacterianos Óvulo/microbiología Pleurobranchaea/metabolismo Pleurobranchaea/microbiología Tetrodotoxina/análisis [Mh] Términos MeSH secundario: Animales Bacterias/genética Cromatografía Líquida de Alta Presión Gónadas/metabolismo Espectrometría de Masas Miocardio/metabolismo Óvulo/metabolismo Pleurobranchaea/crecimiento & desarrollo Reacción en Cadena de la Polimerasa ARN Ribosómico/análisis [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (RNA, Ribosomal); 4368-28-9 (Tetrodotoxin) [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 121130 [St] Status: MEDLINE [do] DOI: 10.1007/s10886-012-0212-9

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[PMID]: 22982884 [Au] Autor: Marlatt VL; Lo BP; Ornostay A; Hogan NS; Kennedy CJ; Elphick JR; Martyniuk CJ [Ad] Dirección: Nautilus Environmental, Imperial Square Lake City, Burnaby, British Columbia, Canada. vicki.marlatt@ufv.ca [Ti] Título: The effects of the urea-based herbicide linuron on reproductive endpoints in the fathead minnow (Pimephales promelas). [So] Fuente: Comp Biochem Physiol C Toxicol Pharmacol;157(1):24-32, 2013 Jan. [Is] ISSN: 1532-0456 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: Linuron is a widely used urea-based herbicide that has anti-androgenic activity in both fish and rodents. To further elucidate the potential mode of action (MOA) of linuron on the vertebrate endocrine system, adult male and female fathead minnows were exposed for 21 days to dechlorinated water, a solvent control, 17ß-estradiol (E2; 0.1 µg/L), dihydrotestosterone (DHT; 100 µg/L), linuron (1, 10, 100 µg/L) and one co-treatment of DHT (100 µg/L) and linuron (100 µg/L). There were no effects of linuron on egg hatching, 7 day egg survival, nuptial tubercle formation or gonadal histopathology. Administration of DHT and 1 and 100 µg/L linuron reduced plasma vitellogenin in females, while male plasma vitellogenin were induced after E2 exposure and co-exposure of DHT and linuron. Ovarian mRNA levels were examined for several genes involved in steroidogenesis (e.g. p450scc, cyp19a, star, tspo, hsd17b and hsd11b) and estrogen-mediated responses (esr1, esr2b, esr2a). Only p450scc mRNA was significantly decreased with DHT+linuron co-treatment. Clustering of steroidogenic mRNA transcript expression patterns revealed that patterns for linuron were more similar to E2 compared to DHT. Collectively, this study supports the hypothesis that linuron may not be a pure anti-androgen and may have multiple MOAs that affect vertebrate reproduction. [Mh] Términos MeSH primario: Cyprinidae/fisiología Linurona/farmacología Reproducción/efectos de drogas Contaminantes Químicos del Agua/farmacología [Mh] Términos MeSH secundario: Andrógenos/farmacología Animales Análisis por Conglomerados Cyprinidae/genética Dihidrotestosterona/farmacología Estradiol/farmacología Estrógenos/farmacología Femenino Perfilación de la Expresión Génica Gónadas/efectos de drogas Gónadas/crecimiento & desarrollo Herbicidas/farmacología Masculino Ovario/efectos de drogas Ovario/metabolismo Óvulo/efectos de drogas Óvulo/crecimiento & desarrollo Reproducción/genética Reacción en Cadena de la Polimerasa de Transcriptasa Inversa Urea/farmacología Vitelogeninas/sangre [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (Androgens); 0 (Estrogens); 0 (Herbicides); 0 (Vitellogenins); 0 (Water Pollutants, Chemical); 330-55-2 (Linuron); 50-28-2 (Estradiol); 521-18-6 (Dihydrotestosterone); 57-13-6 (Urea) [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 121126 [St] Status: MEDLINE

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[PMID]: 23056415 [Au] Autor: Pujolar JM; Locatello L; Zane L; Mazzoldi C [Ad] Dirección: Department of Biology, University of Padova, Padova, Italy. [Ti] Título: Body size correlates with fertilization success but not gonad size in grass goby territorial males. [So] Fuente: PLoS One;7(10):e46711, 2012. [Is] ISSN: 1932-6203 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: In fish species with alternative male mating tactics, sperm competition typically occurs when small males that are unsuccessful in direct contests steal fertilization opportunities from large dominant males. In the grass goby Zosterisessor ophiocephalus, large territorial males defend and court females from nest sites, while small sneaker males obtain matings by sneaking into nests. Parentage assignment of 688 eggs from 8 different nests sampled in the 2003-2004 breeding season revealed a high level of sperm competition. Fertilization success of territorial males was very high but in all nests sneakers also contributed to the progeny. In territorial males, fertilization success correlated positively with male body size. Gonadal investment was explored in a sample of 126 grass gobies collected during the period 1995-1996 in the same area (61 territorial males and 65 sneakers). Correlation between body weight and testis weight was positive and significant for sneaker males, while correlation was virtually equal to zero in territorial males. That body size in territorial males is correlated with fertilization success but not gonad size suggests that males allocate much more energy into growth and relatively little into sperm production once the needed size to become territorial is attained. The increased paternity of larger territorial males might be due to a more effective defense of the nest in comparison with smaller territorial males. [Mh] Términos MeSH primario: Tamaño Corporal/fisiología Fertilización/fisiología Gónadas/crecimiento & desarrollo Perciformes/crecimiento & desarrollo Perciformes/fisiología [Mh] Términos MeSH secundario: Animales Femenino Masculino [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 121011 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0046711

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[PMID]: 22248714 [Au] Autor: Hyodo H; Ishiguro H; Tomita Y; Takakura H; Koike T; Shimizu T; Morimoto T; Yabe H; Yabe M; Kojima S; Shiraishi K; Minemura T; Kato S [Ad] Dirección: Department of Pediatrics, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan. [Ti] Título: Decreased serum testosterone levels in long-term adult survivors with fatty liver after childhood stem cell transplantation. [So] Fuente: Biol Blood Marrow Transplant;18(7):1119-27, 2012 Jul. [Is] ISSN: 1523-6536 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: Fatty liver and male gonadal dysfunction are potential late effects of therapy in adult survivors treated with stem cell transplantation (SCT) in childhood. Obesity and metabolic syndrome also are associated with low serum testosterone levels in the general population. However, the relationship between the degree of fatty liver and changes in serum testosterone levels in adult survivors has not been fully studied. We reviewed the clinical records of 34 male patients who received allogeneic SCT in childhood or adolescence. The median age at SCT was 10.0 years, and the median follow-up after SCT was 15.9 years. All but one patient showed no tendency toward overweight/obesity during the follow-up period. Fatty liver was diagnosed by ultrasound in 15 patients at 4 to 20 years after SCT. Patients who received cranial radiation therapy before SCT were more likely to develop fatty liver and insulin resistance. Moreover, fatty liver was statistically associated with decreased serum testosterone levels, whereas nonfatty liver was not (median, 527 ng/dL [range, 168-944 ng/dL] versus 302 ng/dL [165-698 ng/dL]; P < .0001). Changes in testosterone levels after SCT are affected not only by primary gonadal dysfunction but also by subsequent development or exacerbation of fatty liver. [Mh] Términos MeSH primario: Hígado Graso/sangre Trasplante de Células Madre Hematopoyéticas Testosterona/sangre Acondicionamiento Pretrasplante/métodos [Mh] Términos MeSH secundario: Adolescente Adulto Glucemia/análisis Encéfalo/efectos de radiación Niño Preescolar Hígado Graso/etiología Hígado Graso/ultrasonografía Estudios de Seguimiento Rayos gamma/efectos adversos Gónadas/efectos de radiación Neoplasias Hematológicas/radioterapia Humanos Resistencia a la Insulina Metabolismo de los Lípidos/efectos de radiación Hígado/efectos de radiación Hígado/ultrasonografía Masculino Sobrevivientes Trasplante Homólogo [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (Blood Glucose); 58-22-0 (Testosterone) [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 120612 [St] Status: MEDLINE [do] DOI: 10.1016/j.bbmt.2012.01.004

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[PMID]: 23401550 [Au] Autor: Nakata T; Ishiguro M; Aduma N; Izumi H; Kuroiwa A [Ad] Dirección: Graduate School of Life Science, Hokkaido University, Hokkaido 060-0810, Japan. [Ti] Título: Chicken hemogen homolog is involved in the chicken-specific sex-determining mechanism. [So] Fuente: Proc Natl Acad Sci U S A;110(9):3417-22, 2013 Feb 26. [Is] ISSN: 1091-6490 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: Using a comprehensive transcriptome analysis, a Z chromosome-linked chicken homolog of hemogen (cHEMGN) was identified and shown to be specifically involved in testis differentiation in early chicken embryos. Hemogen [Hemgn in mice, EDAG (erythroid differentiation-associated gene protein) in humans] was recently characterized as a hematopoietic tissue-specific gene encoding a transcription factor that regulates the proliferation and differentiation of hematopoietic cells in mammals. In chicken, cHEMGN was expressed not only in hematopoietic tissues but also in the early embryonic gonad of male chickens. The male-specific expression was identified in the nucleus of (pre)Sertoli cells after the sex determination period and before the expression of SOX9 (SRY-box 9). The expression of cHEMGN was induced in ZW embryonic gonads that were masculinized by aromatase inhibitor treatment. ZW embryos overexpressing cHEMGN, generated by infection with retrovirus carrying cHEMGN, showed masculinized gonads. These findings suggest that cHEMGN is a transcription factor specifically involved in chicken sex determination. [Mh] Términos MeSH primario: Pollos/metabolismo Proteínas Nucleares/metabolismo Homología de Secuencia de Aminoácido Procesos de Determinación del Sexo [Mh] Términos MeSH secundario: Animales Inhibidores de la Aromatasa/farmacología Núcleo Celular/efectos de drogas Núcleo Celular/metabolismo Embrión de Pollo Cromosomas/metabolismo ADN Complementario/genética Femenino Regulación del Desarrollo de la Expresión Génica/efectos de drogas Gónadas/efectos de drogas Gónadas/metabolismo Hematopoyesis/efectos de drogas Hematopoyesis/genética Humanos Masculino Ratones Proteínas Nucleares/genética Procesos de Determinación del Sexo/efectos de drogas Especificidad de la Especie [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (Aromatase Inhibitors); 0 (DNA, Complementary); 0 (Nuclear Proteins) [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 130227 [St] Status: MEDLINE [do] DOI: 10.1073/pnas.1218714110

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