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  1 / 191175 MEDLINE  
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[PMID]:29505505
[Au] Autor:Zhang ZG; Liu XM
[Ti] Título:A case report with shock induced by tolvaptan in an elderly patient with congestive heart failure.
[So] Fuente:Medicine (Baltimore);97(1):e8706, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:RATIONALE: Tolvaptan (TLV) is a new vasopressin type 2 receptor antagonist effective in patients with heart failure (HF). Accumulating evidences have revealed that treatment with TLV does not alter the blood pressure significantly. PATIENT CONCERNS: An 84-year-old man was diagnosed with acute exacerbation of chronic HF due to ischemic cardiomyopathy, arrhythmia, mitral and aortic regurgitation. Treatment with TLV increased the urine volume and improved the dyspnea. After 4 days use of TLV (3.75 mg QD, 7.5 mg QD, 7.5 mg QD, and 15 mg QD, respectively), decrease in blood pressure to less than 90/60 mmHg was observed continuously and the lowest blood pressure was 80/37 mmHg. He was apyretic and felt only thirsty. Central venous pressure was 12 cmH2O. DIAGNOSES: Because no other medications were changed and no signs of hypovolemic, septic, allergic, or cardiac shock were detected, we suspected an adverse reaction to TLV. INTERVENTION: Intravenous hydration was performed with 250 mL of normal saline. OUTCOMES: His blood pressure increased gradually and the statue of hypotention lasted for 14 hours. The dose of TLV was decreased to 7.5 mg/d from the next day to discharge. During this period, his blood pressure was stable at about 125/60 mmHg. LESSONS: TLV has side effect of severe hypotension that is consistent with its physiological activity. The dose should be increased gradually to achieve the desired effect, while attention should be paid to potential drug interactions.
[Mh] Términos MeSH primario: Antagonistas de Receptores de Hormonas Antidiuréticas/efectos adversos
Benzazepinas/efectos adversos
Insuficiencia Cardíaca/tratamiento farmacológico
Choque/inducido químicamente
[Mh] Términos MeSH secundario: Anciano de 80 o más Años
Seres Humanos
Masculino
[Pt] Tipo de publicación:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Antidiuretic Hormone Receptor Antagonists); 0 (Benzazepines); 21G72T1950 (tolvaptan)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:180306
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008706


  2 / 191175 MEDLINE  
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[PMID]:29447189
[Au] Autor:Saleem AR; Brunetti C; Khalid A; Della Rocca G; Raio A; Emiliani G; De Carlo A; Mahmood T; Centritto M
[Ad] Dirección:Department of Earth and Environmental Sciences, Bahria University Islamabad Campus, Islamabad, Pakistan.
[Ti] Título:Drought response of Mucuna pruriens (L.) DC. inoculated with ACC deaminase and IAA producing rhizobacteria.
[So] Fuente:PLoS One;13(2):e0191218, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Drought is one of the major constraints limiting agricultural production worldwide and is expected to increase in the future. Limited water availability causes significant effects to plant growth and physiology. Plants have evolved different traits to mitigate the stress imposed by drought. The presence of plant growth-promoting rhizobacteria (PGPR) could play an important role in improving plant performances and productivity under drought. These beneficial microorganisms colonize the rhizosphere of plants and increase drought tolerance by lowering ethylene formation. In the present study, we demonstrate the potential to improve the growth of velvet bean under water deficit conditions of two different strains of PGPR with ACCd (1-Aminocyclopropane-1-Carboxylate deaminase) activity isolated from rainfed farming system. We compared uninoculated and inoculated plants with PGPR to assess: a) photosynthetic performance and biomass; b) ACC content and ethylene emission from leaves and roots; c) leaf isoprene emission. Our results provided evidence that under drought conditions inoculation with PGPR containing the ACCd enzyme could improve plant growth compared to untreated plants. Ethylene emission from roots and leaves of inoculated velvet bean plants was significantly lower than uninoculated plants. Moreover, isoprene emission increased with drought stress progression and was higher in inoculated plants compared to uninoculated counterparts. These findings clearly illustrate that selected PGPR strains isolated from rainfed areas could be highly effective in promoting plant growth under drought conditions by decreasing ACC and ethylene levels in plants.
[Mh] Términos MeSH primario: Mucuna/metabolismo
Reguladores del Crecimiento de las Plantas/metabolismo
Rhizobiaceae/metabolismo
[Mh] Términos MeSH secundario: Biomasa
Liasas de Carbono-Carbono/metabolismo
Sequías
Etilenos/biosíntesis
Mucuna/fisiología
Fotosíntesis
Desarrollo de la Planta
Reguladores del Crecimiento de las Plantas/fisiología
Raíces de Plantas/crecimiento & desarrollo
Rhizobiaceae/genética
Rizosfera
Microbiología del Suelo
Agua/fisiología
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nombre de substancia:
0 (Ethylenes); 0 (Plant Growth Regulators); 059QF0KO0R (Water); 91GW059KN7 (ethylene); EC 3.5.99.7 (1-aminocyclopropane-1-carboxylate deaminase); EC 4.1.- (Carbon-Carbon Lyases)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191218


  3 / 191175 MEDLINE  
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[PMID]:29409851
[Au] Autor:Tan M; Li G; Qi S; Liu X; Chen X; Ma J; Zhang D; Han M
[Ad] Dirección:College of Horticulture, Northwest A & F University, Yangling, Shaanxi 712100, China.
[Ti] Título:Identification and expression analysis of the IPT and CKX gene families during axillary bud outgrowth in apple (Malus domestica Borkh.).
[So] Fuente:Gene;651:106-117, 2018 Apr 20.
[Is] ISSN:1879-0038
[Cp] País de publicación:Netherlands
[La] Idioma:eng
[Ab] Resumen:Cytokinins (CKs) play a crucial role in promoting axillary bud outgrowth and targeting the control of CK metabolism can be used to enhance branching in plants. CK levels are maintained mainly by CK biosynthesis (isopentenyl transferase, IPT) and degradation (dehydrogenase, CKX) genes in plants. A systematic study of the IPT and CKX gene families in apple, however, has not been conducted. In the present study, 12 MdIPTs and 12 MdCKXs were identified in the apple genome. Systematic phylogenetic, structural, and synteny analyses were performed. Expression analysis of these genes in different tissues was also assessed. MdIPT and MdCKX genes exhibit distinct expression patterns in different tissues. The response of MdIPT, MdCKX, and MdPIN1 genes to various treatments (6-BA, decapitation and Lovastatin, an inhibitor of CKs synthesis) that impact branching were also investigated. Results indicated that most of the MdIPT and MdCKX, and MdPIN1 genes were upregulated by 6-BA and decapitation treatment, but inhibited by Lovastatin, a compound that effectively suppresses axillary bud outgrowth induced by decapitation. These findings suggest that cytokinin biosynthesis is required for the activation of bud break and the export of auxin from buds in apple tree with intact primary shoot apex or decapitated apple tree. MdCKX8 and MdCKX10, however, exhibited little response to decapitation, but were significantly up-regulated by 6-BA and Lovastatin, a finding that warrants further investigation in order to understand their function in bud-outgrowth.
[Mh] Términos MeSH primario: Transferasas Alquil y Aril/genética
Genes de Plantas
Malus/genética
Oxidorreductasas/genética
[Mh] Términos MeSH secundario: Arabidopsis/genética
Compuestos de Bencilo/farmacología
Mapeo Cromosómico
Cromosomas de las Plantas
Evolución Molecular
Flores/genética
Perfilación de la Expresión Génica
Regulación de la Expresión Génica de las Plantas
Genoma de Planta
Lovastatina/farmacología
Malus/enzimología
Malus/crecimiento & desarrollo
Familia de Multigenes
Filogenia
Reguladores del Crecimiento de las Plantas
Purinas/farmacología
Sintenía
Regulación hacia Arriba
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Benzyl Compounds); 0 (Plant Growth Regulators); 0 (Purines); 9LHU78OQFD (Lovastatin); EC 1.- (Oxidoreductases); EC 1.5.99.12 (cytokinin oxidase); EC 2.5.- (Alkyl and Aryl Transferases); EC 2.5.1.27 (adenylate isopentenyltransferase); KXG6A989PS (benzylaminopurine)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180208
[St] Status:MEDLINE


  4 / 191175 MEDLINE  
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[PMID]:29332223
[Au] Autor:Togasaki E; Shimizu N; Nagao Y; Kawajiri-Manako C; Shimizu R; Oshima-Hasegawa N; Muto T; Tsukamoto S; Mitsukawa S; Takeda Y; Mimura N; Ohwada C; Takeuchi M; Sakaida E; Iseki T; Yoshitomi H; Ohtsuka M; Miyazaki M; Nakaseko C
[Ad] Dirección:Department of Hematology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8677, Japan.
[Ti] Título:Long-term efficacy of partial splenic embolization for the treatment of steroid-resistant chronic immune thrombocytopenia.
[So] Fuente:Ann Hematol;97(4):655-662, 2018 Apr.
[Is] ISSN:1432-0584
[Cp] País de publicación:Germany
[La] Idioma:eng
[Ab] Resumen:Thrombopoietin-receptor agonists have been recently introduced for a second-line treatment of immune thrombocytopenia (ITP). Splenectomy has tended to be avoided because of its complications, but the response rate of splenectomy is 60-80% and it has still been considered for steroid-refractory ITP. We performed partial splenic embolization (PSE) as an alternative to splenectomy. Between 1988 and 2013, 91 patients with steroid-resistant ITP underwent PSE at our hospital, and we retrospectively analyzed the efficacy and long-term outcomes of PSE. The complete response rate (CR, platelets > 100 × 10 /L) was 51% (n = 46), and the overall response rate (CR plus response (R), > 30 × 10 /L) was 84% (n = 76). One year after PSE, 70% of patients remained CR and R. The group with peak platelet count after PSE ≥ 300 × 10 /L (n = 29) exhibited a significantly higher platelet count than the group with platelet count < 300 × 10 /L (n = 40) at any time point after PSE. The failure-free survival (FFS) rates at 1, 5, and 10 years were 78, 56, and 52%, respectively. Second PSE was performed in 20 patients who relapsed (n = 14) or had no response to the initial PSE (n = 6), and the overall response was achieved in 63% patients. There were no PSE-related deaths. These results indicate that PSE is a safe and effective alternative therapy to splenectomy for patients with steroid-resistant ITP as it generates long-term, durable responses.
[Mh] Términos MeSH primario: Embolización Terapéutica
Púrpura Trombocitopénica Idiopática/terapia
Bazo/irrigación sanguínea
[Mh] Términos MeSH secundario: Adolescente
Corticoesteroides/uso terapéutico
Adulto
Anciano
Anciano de 80 o más Años
Supervivencia sin Enfermedad
Resistencia a Medicamentos
Resistencia a Múltiples Medicamentos
Embolización Terapéutica/efectos adversos
Femenino
Estudios de Seguimiento
Hospitales Universitarios
Seres Humanos
Japón
Masculino
Mediana Edad
Tamaño de los Órganos
Púrpura Trombocitopénica Idiopática/diagnóstico por imagen
Púrpura Trombocitopénica Idiopática/tratamiento farmacológico
Púrpura Trombocitopénica Idiopática/patología
Estudios Retrospectivos
Bazo/diagnóstico por imagen
Bazo/efectos de los fármacos
Bazo/patología
Esteroides/uso terapéutico
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nombre de substancia:
0 (Adrenal Cortex Hormones); 0 (Steroids)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180115
[St] Status:MEDLINE
[do] DOI:10.1007/s00277-018-3232-x


  5 / 191175 MEDLINE  
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[PMID]:29214535
[Au] Autor:Mijangos L; Ziarrusta H; Olivares M; Zuloaga O; Möder M; Etxebarria N; Prieto A
[Ad] Dirección:Department of Analytical Chemistry, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), P.O. Box 644, 48080, Bilbao, Spain.
[Ti] Título:Simultaneous determination of 41 multiclass organic pollutants in environmental waters by means of polyethersulfone microextraction followed by liquid chromatography-tandem mass spectrometry.
[So] Fuente:Anal Bioanal Chem;410(2):615-632, 2018 Jan.
[Is] ISSN:1618-2650
[Cp] País de publicación:Germany
[La] Idioma:eng
[Ab] Resumen:A new procedure using polyethersulfone (PES) microextraction followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis was developed in this work for the simultaneous determination of 41 multiclass priority and emerging organic pollutants including herbicides, hormones, personal care products, and pharmaceuticals, among others, in seawater, wastewater treatment plant (WWTP) effluents, and estuary samples. The optimization of the analysis included two different chromatographic columns and different variables (polarity, fragmentor voltage, collision energy, and collision cell accelerator) of the mass spectrometer. In the case of PES extraction, ion strength of the water, pH, addition of EDTA, and the amount of the polymeric material were thoroughly investigated. The developed procedure was compared with a previously validated one based on a standard solid-phase extraction (SPE). In contrast to the SPE protocol, the PES method allowed a cost-efficient extraction of complex aqueous samples with lower matrix effect from 120 mL of water sample. Satisfactory and comparable apparent recovery values (80-119 and 70-131%) and method quantification limits (MQLs, 0.4-26 and 0.2-23 ng/L) were obtained for PES and SPE procedures, respectively, regardless of the matrix. Repeatability values lower than 27% were obtained. Finally, the developed methods were applied to the analysis of real samples from the Basque Country and irbesartan, valsartan, acesulfame, and sucralose were the analytes most often detected at the highest concentrations (51-1096 ng/L). Graphical abstract Forty-one multiclass pollutant determination in environmental waters by means of PES/SPE-LC-MS/MS.
[Mh] Términos MeSH primario: Herbicidas/análisis
Hormonas/análisis
Preparaciones Farmacéuticas/análisis
Polímeros/química
Extracción en Fase Sólida/métodos
Sulfonas/química
Espectrometría de Masas en Tándem/métodos
Contaminantes Químicos del Agua/análisis
[Mh] Términos MeSH secundario: Cromatografía Liquida/métodos
Estuarios
Límite de Detección
Agua de Mar/análisis
Aguas Residuales/análisis
[Pt] Tipo de publicación:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nombre de substancia:
0 (Herbicides); 0 (Hormones); 0 (Pharmaceutical Preparations); 0 (Polymers); 0 (Sulfones); 0 (Waste Water); 0 (Water Pollutants, Chemical); 25667-42-9 (polyether sulfone)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:171208
[St] Status:MEDLINE
[do] DOI:10.1007/s00216-017-0763-2


  6 / 191175 MEDLINE  
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[PMID]:29175396
[Au] Autor:Wang F; Liu F; Chen W; Xu R; Wang W
[Ad] Dirección:School of Biological Science, Luoyang Normal University, Luoyang, 471022, China; Cold Water Fish Breeding Engineering Technology Research Center of Henan Province, Luoyang, 471022, China. Electronic address: wangfan7677@163.com.
[Ti] Título:Effects of triclosan (TCS) on hormonal balance and genes of hypothalamus-pituitary- gonad axis of juvenile male Yellow River carp (Cyprinus carpio).
[So] Fuente:Chemosphere;193:695-701, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Triclosan (TCS) is a broad spectrum antimicrobial agent which has been widely dispersed and determinated in the aquatic environment. However, the effects of TCS on reproductive endocrine in male fish are poorly understood. In this study, male Yellow River carp (Cyprinus carpio) were exposed to 0, 1/5, 1/10 and 1/20 LC (96 h LC of TCS to carp) TCS under semi-static conditions for 42 d. Vitellogenin (Vtg), 17ß-estradiol (E ), testosterone(T), gonadotropin (GtH), and gonadotropin-releasing hormone (GnRH) levels were measured by enzyme-linked immunosorbent assay (ELISA). Meanwhile, we also examined the mRNA expressions of aromatase, GtHs-ß, GnRH, estrogen receptor (Er), and androgen receptor (Ar) by quantitative Real-time Polymerase Chain Reaction (qRT-PCR). TCS induced Vtg levels of hepatopancreas, E levels of serum, and inhibited Ar and Er mRNA levels, suggesting that the induction of Vtg production by TCS was indirectly caused by non-Er pathways. TCS-induced Vtg levels by interfering with the reproductive axis at plenty of latent loci of male carps: (a) TCS exposure increased the aromatase mRNA expression of hypothalamus and gonad aromatase, consequently increasing serum concentrations of E to induce Vtg in hepatopancreas; (b) TCS treatment changed GtH-ß and GnRH mRNA expression and secretion, causing the disturbance of reproductive endocrine; (c) TCS exposure decreased Ar mRNA levels, indicating potential Ar-mediated antiandrogen action. These mechanisms showed that TCS may induce Vtg production in male carp by non-Er-mediated pathways.
[Mh] Términos MeSH primario: Carpas/metabolismo
Triclosán/toxicidad
Contaminantes Químicos del Agua/toxicidad
[Mh] Términos MeSH secundario: Animales
Antiinfecciosos/toxicidad
Aromatasa/genética
Sistema Endocrino/efectos de los fármacos
Ensayo de Inmunoadsorción Enzimática
Estradiol/análisis
Hormona Liberadora de Gonadotropina/análisis
Hormona Liberadora de Gonadotropina/genética
Gónadas/enzimología
Gónadas/metabolismo
Hepatopáncreas/metabolismo
Hormonas/metabolismo
Hipotálamo/metabolismo
Masculino
Hipófisis/metabolismo
ARN Mensajero/análisis
Reacción en Cadena en Tiempo Real de la Polimerasa
Receptores Estrogénicos/genética
Reproducción/efectos de los fármacos
Testosterona/análisis
Vitelogeninas/análisis
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Anti-Infective Agents); 0 (Hormones); 0 (RNA, Messenger); 0 (Receptors, Estrogen); 0 (Vitellogenins); 0 (Water Pollutants, Chemical); 33515-09-2 (Gonadotropin-Releasing Hormone); 3XMK78S47O (Testosterone); 4NM5039Y5X (Triclosan); 4TI98Z838E (Estradiol); EC 1.14.14.1 (Aromatase); EC 1.14.14.1 (CYP19A1 protein, human)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:171128
[St] Status:MEDLINE


  7 / 191175 MEDLINE  
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[PMID]:28451931
[Au] Autor:Casajoana A; Pujol J; Garcia A; Elvira J; Virgili N; de Oca FJ; Duran X; Fernández-Veledo S; Vendrell J; Vilarrasa N
[Ad] Dirección:Bariatric Surgery Unit, Bellvitge University Hospital-IDIBELL, c/ Feixa Llarga s/n, 08907, Barcelona, L'Hospitalet de Llobregat, Spain.
[Ti] Título:Predictive Value of Gut Peptides in T2D Remission: Randomized Controlled Trial Comparing Metabolic Gastric Bypass, Sleeve Gastrectomy and Greater Curvature Plication.
[So] Fuente:Obes Surg;27(9):2235-2245, 2017 Sep.
[Is] ISSN:1708-0428
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:BACKGROUND: Our aim was to determine the predictive value of gut hormone changes for the improvement of type 2 diabetes (T2D) following metabolic Roux-en-Y gastric bypass (mRYGB), sleeve gastrectomy (SG), and greater curvature plication (GCP) in a randomized controlled trial. Contradictory results have been obtained regarding the role of gastrointestinal hormones (in particular GLP-1) in beneficial metabolic bariatric surgery outcomes. METHODS: Forty-five patients with T2D (mean BMI 39.4 ± 1.9 kg/m ) were randomly assigned to mRYGB, SG, or GCP. Anthropometric and biochemical parameters, fasting concentrations of PYY, ghrelin, glucagon, and area under the curve (AUC) of GLP-1 after a standard meal test were determined prior to and at months 1 and 12 after surgery. RESULTS: Twelve months after surgery, total weight loss percentage was higher and HbA1c lower in the mRYGB group than in the SG and GCP groups (-35.2 ± 8.1 and 5.1 ± 0.6% vs. -27.8 ± 5.4 and 6.2 ± 0.8% vs. -20.5 ± 6.8 and 6.6 ± 1.3%; p = 0.007 and p < 0.001, respectively). Moreover, GLP-1 AUC at months 1 and 12 was greater and T2D remission was higher in mRYGB (80 vs. 53.3 vs. 20%, p < 0.001). Insulin treatment (odds ratio (OR) 0.025, p = 0.018) and the increase in GLP-1 AUC from baseline to month 1 (OR 1.021, p = 0.013) were associated with T2D remission. CONCLUSIONS: mRYGB achieves a superior rate of weight loss and T2D remission at month 12. Enhanced GLP-1 secretion 1 month after surgery was a determinant of glucose metabolism improvement. Registration number ( http://www.clinicaltrials.gov ): NCT14104758.
[Mh] Términos MeSH primario: Diabetes Mellitus Tipo 2/cirugía
Gastrectomía/métodos
Derivación Gástrica/métodos
Gastroplastia/métodos
[Mh] Términos MeSH secundario: Adulto
Diabetes Mellitus Tipo 2/complicaciones
Femenino
Hormonas Gastrointestinales/metabolismo
Péptido 1 Similar al Glucagón/metabolismo
Seres Humanos
Masculino
Mediana Edad
Obesidad Mórbida/complicaciones
Obesidad Mórbida/cirugía
Inducción de Remisión
Estómago/cirugía
Pérdida de Peso
[Pt] Tipo de publicación:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nombre de substancia:
0 (Gastrointestinal Hormones); 89750-14-1 (Glucagon-Like Peptide 1)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s11695-017-2669-7


  8 / 191175 MEDLINE  
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[PMID]:29267659
[Au] Autor:Jana A; Thomas J; Ghosh P
[Ad] Dirección:PMS College of Dental Science & Research, Department of Physiology, Kerala, India.
[Ti] Título:P-glycoprotein expression in oral lichen planus.
[So] Fuente:Braz Oral Res;31:e95, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] País de publicación:Brazil
[La] Idioma:eng
[Ab] Resumen:Oral lichen planus (OLP) is a stress induced inflammatory condition with malignant potency. The mdr1 (multidrug resistance) is a stress gene overexpressed in cancerous conditions and its translated form, the p-glycoprotein efflux transporter is usually overexpressed with chemotherapy, leading to chemoresistance. OLP, a lesion with carcinogenic potency, is broadly classified into the asymptomatic reticular form and the aggressive erosive form. The objective of the study was to verify the expression level of p-glycoprotein in antifungal-treated and untreated reticular OLP, in untreated erosive OLP and erosive OLP patients treated with corticosteroid. Semi-quantitative reverse transcriptase polymerase chain reaction (SQ-RTPCR) and ELISA were performed on biopsy tissue samples to evaluate the mdr1 mRNA and protein expression of p-glycoprotein, respectively. The present study shows for the first time that mdr1 mRNA as well as its translated form p-glycoprotein are overexpressed in OLP subjects compared to healthy individuals. This overexpression is significantly higher in erosive than in reticular OLP patients, further confirming that the erosive form has higher risk for multidrug resistance. A higher expression is also observed in corticosteroid-treated erosive cases than similar untreated ones. The gradation of expression is in conformity with severity of the disease.
[Mh] Términos MeSH primario: Subfamilia B de Transportador de Casetes de Unión a ATP/metabolismo
Corticoesteroides/uso terapéutico
Antifúngicos/uso terapéutico
Liquen Plano Oral/tratamiento farmacológico
Liquen Plano Oral/metabolismo
[Mh] Términos MeSH secundario: Adulto
Análisis de Varianza
Biopsia
Farmacorresistencia Fúngica Múltiple
Ensayo de Inmunoadsorción Enzimática
Femenino
Seres Humanos
Liquen Plano Oral/patología
Masculino
Mediana Edad
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
Índice de Severidad de la Enfermedad
Piel/patología
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (ATP Binding Cassette Transporter, Sub-Family B); 0 (Adrenal Cortex Hormones); 0 (Antifungal Agents)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180308
[Lr] Fecha última revisión:180308
[Sb] Subgrupo de revista:D; IM
[Da] Fecha de ingreso para procesamiento:171222
[St] Status:MEDLINE


  9 / 191175 MEDLINE  
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[PMID]:29029379
[Au] Autor:Shahzad B; Tanveer M; Che Z; Rehman A; Cheema SA; Sharma A; Song H; Rehman SU; Zhaorong D
[Ad] Dirección:School of Land and Food, University of Tasmania, Hobart, Tasmania, Australia. Electronic address: bs_tahir786@yahoo.com.
[Ti] Título:Role of 24-epibrassinolide (EBL) in mediating heavy metal and pesticide induced oxidative stress in plants: A review.
[So] Fuente:Ecotoxicol Environ Saf;147:935-944, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicación:Netherlands
[La] Idioma:eng
[Ab] Resumen:Industrialization and urbanization have posed serious threats to the environment. Excessive release of heavy metals from industrial effluents and overuse of pesticides in modern agriculture are limiting crop production by polluting environment and deteriorating food quality. Sustaining food quality under heavy metals and pesticide stress is crucial to meet the increasing demands for food. 24-Epibrassinolide (EBL), a ubiquitously occurring plant growth hormone shows great potential to alleviate heavy metals and pesticide stress in plants. This review sums up the potential role of EBL in ameliorating heavy metals and pesticide toxicity in plants extensively. EBL application increases plant's overall growth, biomass accumulation and photosynthetic efficiency by the modulation of numerous biochemical and physiological processes under heavy metals and pesticide stress. In addition, EBL scavenges reactive oxygen species (ROS) by triggering the production of antioxidant enzymes such as SOD, CAT, POX etc. EBL also induces the production of proline and soluble proteins that helps in maintaining osmotic potential and osmo-protection under both heavy metals and pesticide stress. At the end, future needs of research about the application of 24-epibrassinolide have also been discussed.
[Mh] Términos MeSH primario: Brasinoesteroides/farmacología
Productos Agrícolas/efectos de los fármacos
Metales Pesados/toxicidad
Estrés Oxidativo/efectos de los fármacos
Plaguicidas/toxicidad
Reguladores del Crecimiento de las Plantas/farmacología
Contaminantes del Suelo/toxicidad
Esteroides Heterocíclicos/farmacología
[Mh] Términos MeSH secundario: Antioxidantes/metabolismo
Productos Agrícolas/metabolismo
Especies Reactivas de Oxígeno/metabolismo
[Pt] Tipo de publicación:JOURNAL ARTICLE; REVIEW
[Nm] Nombre de substancia:
0 (Antioxidants); 0 (Brassinosteroids); 0 (Metals, Heavy); 0 (Pesticides); 0 (Plant Growth Regulators); 0 (Reactive Oxygen Species); 0 (Soil Pollutants); 0 (Steroids, Heterocyclic); Y9IQ1L53OX (brassinolide)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180308
[Lr] Fecha última revisión:180308
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:171015
[St] Status:MEDLINE


  10 / 191175 MEDLINE  
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[PMID]:28942280
[Au] Autor:Edwards TM; Hamlin HJ; Freymiller H; Green S; Thurman J; Guillette LJ
[Ad] Dirección:Department of Biology, University of the South, Sewanee, TN, USA; Department of Biology, University of Florida, Gainesville, FL, USA; School of Biological Sciences, Louisiana Tech University, Ruston, LA, USA. Electronic address: theamedwards@gmail.com.
[Ti] Título:Nitrate induces a type 1 diabetic profile in alligator hatchlings.
[So] Fuente:Ecotoxicol Environ Saf;147:767-775, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicación:Netherlands
[La] Idioma:eng
[Ab] Resumen:Type 1 diabetes (T1D) is a chronic autoimmune disease that affects 1 in 300 children by age 18. T1D is caused by inflammation-induced loss of insulin-producing pancreatic beta cells, leading to high blood glucose and a host of downstream complications. Although multiple genes are associated with T1D risk, only 5% of genetically susceptible individuals actually develop clinical disease. Moreover, a growing number of T1D cases occur in geographic clusters and among children with low risk genotypes. These observations suggest that environmental factors contribute to T1D etiology. One potential factor, supported primarily by epidemiological studies, is the presence of nitrate and nitrite in drinking water. To test this hypothesis, female hatchling alligators were exposed to environmentally relevant concentrations of nitrate in their tank water (reference, 10mg/L, or 100mg/L NO -N) from hatch through 5 weeks or 5 months of age. At each time point, endpoints related to T1D were investigated: plasma levels of glucose, triglycerides, testosterone, estradiol, and thyroxine; pancreas, fat body, and thyroid weights; weight gain or loss; presence of immune cells in the pancreas; and pancreatic beta cell number, assessed by antibody staining of nkx6.1 protein. Internal dosing of nitrate was confirmed by measuring plasma and urine nitrate levels and whole blood methemoglobin. Cluster analysis indicated that high nitrate exposure (most animals exposed to 100mg/L NO3-N and one alligator exposed to 10mg/L NO3-N) induced a profile of endpoints consistent with early T1D that could be detected after 5 weeks and was more strongly present after 5 months. Our study supports epidemiological data correlating elevated nitrate with T1D onset in humans, and highlights nitrate as a possible environmental contributor to the etiology of T1D, possibly through its role as a nitric oxide precursor.
[Mh] Términos MeSH primario: Caimanes y Cocodrilos/sangre
Diabetes Mellitus Experimental/inducido químicamente
Diabetes Mellitus Tipo 1/inducido químicamente
Disruptores Endocrinos/toxicidad
Nitratos/toxicidad
Contaminantes Químicos del Agua/toxicidad
[Mh] Términos MeSH secundario: Caimanes y Cocodrilos/crecimiento & desarrollo
Animales
Glucemia/análisis
Diabetes Mellitus Experimental/sangre
Diabetes Mellitus Tipo 1/sangre
Relación Dosis-Respuesta a Droga
Disruptores Endocrinos/farmacocinética
Monitoreo del Ambiente/métodos
Femenino
Hormonas Esteroides Gonadales/sangre
Nitratos/farmacocinética
Tamaño de los Órganos/efectos de los fármacos
Tiroxina/sangre
Triglicéridos/sangre
Contaminantes Químicos del Agua/farmacocinética
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Blood Glucose); 0 (Endocrine Disruptors); 0 (Gonadal Steroid Hormones); 0 (Nitrates); 0 (Triglycerides); 0 (Water Pollutants, Chemical); Q51BO43MG4 (Thyroxine)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180308
[Lr] Fecha última revisión:180308
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170925
[St] Status:MEDLINE



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