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[PMID]:28240677
[Au] Autor:Bozkurt S; Aktekin L; Ugurlu FG; Balci S; Sezer N; Akkus S
[Ad] Dirección:From the Atatürk Educational and Research Hospital, Physical Medicine and Rehabilitation Clinic (S. Bozkurt); and Physical Medicine and Rehabilitation Department (LA, FGU, NS, SA) and Pathology Department (S. Balci), Yildirim Beyazit University, Ankara, Turkey.
[Ti] Título:An Unusual Cause of Myelopathy: Ochronotic Spondyloarthropathy With Positive HLA B27.
[So] Fuente:Am J Phys Med Rehabil;96(11):e206-e209, 2017 Nov.
[Is] ISSN:1537-7385
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Ochronosis is a late developing complication of alkaptonuria, a black brownish pigment in the fibrous and cartilaginous tissues. Although most previous studies reported alkaptonuria and back pain due to ochronosis, thoracic myelopathy is an extremely rare complication. In this report, a paraparetic patient who has ochronotic spondiloarthropathy with the presence of HLA B27 antigen is described. He had low back and leg pain and morning stiffness for 5 yrs. Last year, these were followed by tingling, numbness, and weakness the in lower extremities and he was operated on with preliminary diagnosis of prolapsed disc herniation and cord compression. Surgery is suggested for disc herniations related to ochronotic spondyloarthropathy if it is necessary or neurologic symptoms are present. However, his pain and weakness have partially recovered after the operation. After medical and physical treatment, he showed clinically significant improvements. This case report demonstrates that the management of ochronosis needs a multidisciplinary approach with physiologic, neurologic, and psychologic effects and proper treatment may significantly improve functional outcomes in these patients.
[Mh] Términos MeSH primario: Antígeno HLA-B27/sangre
Ocronosis/complicaciones
Enfermedades de la Médula Espinal/etiología
Espondiloartropatías/complicaciones
Vértebras Torácicas
[Mh] Términos MeSH secundario: Humanos
Masculino
Mediana Edad
Ocronosis/inmunología
Paraparesia/complicaciones
Paraparesia/inmunología
Enfermedades de la Médula Espinal/inmunología
Espondiloartropatías/inmunología
[Pt] Tipo de publicación:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (HLA-B27 Antigen)
[Em] Mes de ingreso:1710
[Cu] Fecha actualización por clase:171030
[Lr] Fecha última revisión:171030
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:170227
[St] Status:MEDLINE
[do] DOI:10.1097/PHM.0000000000000727


  2 / 606 MEDLINE  
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[PMID]:28643719
[Au] Autor:Damarla N; Linga P; Goyal M; Tadisina SR; Reddy GS; Bommisetti H
[Ad] Dirección:Department of Ophthalmology, Apollo Institute of Medical Sciences and Research, Jubilee Hills, Hyderabad, Telangana, India.
[Ti] Título:Alkaptonuria: A case report.
[So] Fuente:Indian J Ophthalmol;65(6):518-521, 2017 Jun.
[Is] ISSN:1998-3689
[Cp] País de publicación:India
[La] Idioma:eng
[Ab] Resumen:Alkaptonuria is a rare inborn error of metabolism with autosomal recessive inheritance with a mutation in homogentisate 1,2-dioxygenase. It results in accumulation of homogentisic acid in connective tissues (ochronosis). Most common ocular manifestations are bluish-black discoloration of the conjunctiva, cornea, and sclera. In this case report, a 39-year-old Indian male patient with additional ocular features in the retina is described.
[Mh] Términos MeSH primario: Alcaptonuria/complicaciones
Conjuntiva/patología
Córnea/patología
Oftalmopatías/etiología
Ocronosis/complicaciones
Retina/patología
Esclerótica/patología
[Mh] Términos MeSH secundario: Adulto
Alcaptonuria/diagnóstico
Diagnóstico Diferencial
Oftalmopatías/diagnóstico
Humanos
Masculino
Ocronosis/diagnóstico
Tomografía de Coherencia Óptica/métodos
[Pt] Tipo de publicación:CASE REPORTS; JOURNAL ARTICLE
[Em] Mes de ingreso:1710
[Cu] Fecha actualización por clase:171012
[Lr] Fecha última revisión:171012
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170623
[St] Status:MEDLINE
[do] DOI:10.4103/ijo.IJO_337_16


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[PMID]:27943305
[Au] Autor:Lartey M; Krampa FD; Abdul-Rahman M; Quarcoo NL; Yamson P; Hagan PG; Tettey Y; Gyasi R; Adjei AA
[Ad] Dirección:Dermatology Unit, University of Ghana School of Medicine and Dentistry, Accra, Ghana.
[Ti] Título:Use of skin-lightening products among selected urban communities in Accra, Ghana.
[So] Fuente:Int J Dermatol;56(1):32-39, 2017 Jan.
[Is] ISSN:1365-4632
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:BACKGROUND: The practice of skin lightening has been reported from North America, Europe, Asia, and Africa. In literature, some prevalence rates exceed 50%, and both sexes are involved. Common agents used include hydroquinone, mercury, corticosteroids, and caustic agents. The agents are easily accessible and affordable with very little regulation. Cutaneous and systemic side effects occur but do not appear to be a deterrent, as the notion of light skin as a surrogate for beauty is strong. In Ghana, anecdotal reports of high bleaching rates among certain urban communities resulted in a study supported by the Food and Drugs Authority to determine various facets of this practice. METHODS: A cross-sectional study among adults in selected urban fishing communities of Accra was undertaken. Consecutive cases were enrolled after written informed consent. A questionnaire was administered, followed by physical examination and clinical photographs. Descriptive statistics were used to analyze the data. RESULTS: Of the 555 participants from the three communities, prevalence was 279 (50.3%). Duration of use ranged from 2 months to 17 years. Approximately 212 (76%) used more than one product, and 231 (82%) used agents on their face and body. Dermatological features were hypopigmentation 270 (96.8%), other color changes including ochronosis 241 (86.4%), changes in consistency 141 (50.3%), striae 157 (56.3%), and infections 42 (15.1%). CONCLUSIONS: The prevalence of skin bleaching was 50.3% in these communities, which is high considering the adverse effects from the practice. We recommend regulation of products by enforcing the law, more education, and a population prevalence study.
[Mh] Términos MeSH primario: Hipopigmentación/inducido químicamente
Ocronosis/inducido químicamente
Enfermedades Cutáneas Infecciosas/inducido químicamente
Preparaciones para Aclaramiento de la Piel/efectos adversos
Población Urbana/estadística & datos numéricos
[Mh] Términos MeSH secundario: Adolescente
Adulto
Anciano
Anciano de 80 o más Años
Estudios Transversales
Femenino
Ghana
Humanos
Hiperpigmentación/inducido químicamente
Masculino
Mediana Edad
Fotografía
Examen Físico
Preparaciones para Aclaramiento de la Piel/uso terapéutico
Encuestas y Cuestionarios
Factores de Tiempo
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Skin Lightening Preparations)
[Em] Mes de ingreso:1707
[Cu] Fecha actualización por clase:170707
[Lr] Fecha última revisión:170707
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:161212
[St] Status:MEDLINE
[do] DOI:10.1111/ijd.13449


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[PMID]:28028161
[Au] Autor:Taylor AM; Hsueh MF; Ranganath LR; Gallagher JA; Dillon JP; Huebner JL; Catterall JB; Kraus VB
[Ad] Dirección:Lancaster Medical School, Faculty of Health & Medicine, Lancaster University, Lancaster, UK a.m.taylor@lancs.ac.uk.
[Ti] Título:Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing.
[So] Fuente:Rheumatology (Oxford);56(1):156-164, 2017 Jan.
[Is] ISSN:1462-0332
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:OBJECTIVE: Alkaptonuria (AKU) is a rare autosomal recessive disease resulting from a single enzyme deficiency in tyrosine metabolism. As a result, homogentisic acid cannot be metabolized, causing systemic increases. Over time, homogentisic acid polymerizes and deposits in collagenous tissues, leading to ochronosis. Typically, this occurs in joint cartilages, leading to an early onset, rapidly progressing osteoarthropathy. The aim of this study was to examine tissue turnover in cartilage affected by ochronosis and its role in disease initiation and progression. METHODS: With informed patient consent, hip and knee cartilages were obtained at surgery for arthropathy due to AKU (n = 6; 2 knees/4 hips) and OA (n = 12; 5 knees/7 hips); healthy non-arthritic (non-OA n = 6; 1 knee/5 hips) cartilages were obtained as waste from trauma surgery. We measured cartilage concentrations (normalized to dry weight) of racemized aspartate, GAG, COMP and deamidated COMP (D-COMP). Unpaired AKU, OA and non-OA samples were compared by non-parametric Mann-Whitney U test. RESULTS: Despite more extractable total protein being obtained from AKU cartilage than from OA or non-OA cartilage, there was significantly less extractable GAG, COMP and D-COMP in AKU samples compared with OA and non-OA comparators. Racemized Asx (aspartate and asparagine) was significantly enriched in AKU cartilage compared with in OA cartilage. CONCLUSIONS: These novel data represent the first examination of cartilage matrix components in a sample of patients with AKU, representing almost 10% of the known UK alkaptonuric population. Compared with OA and non-OA, AKU cartilage demonstrates a very low turnover state and has low levels of extractable matrix proteins.
[Mh] Términos MeSH primario: Envejecimiento/metabolismo
Alcaptonuria/metabolismo
Cartílago Articular/metabolismo
Artropatías/metabolismo
Ocronosis/metabolismo
[Mh] Términos MeSH secundario: Adulto
Anciano
Anciano de 80 o más Años
Ácido Aspártico/metabolismo
Biomarcadores/metabolismo
Proteína de la Matriz Oligomérica del Cartílago/metabolismo
Estudios de Casos y Controles
Femenino
Glucosaminoglicanos/metabolismo
Articulación de la Cadera
Humanos
Articulación de la Rodilla
Masculino
Mediana Edad
Osteoartritis de la Cadera/metabolismo
Osteoartritis de la Rodilla/metabolismo
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Biomarkers); 0 (Cartilage Oligomeric Matrix Protein); 0 (Glycosaminoglycans); 30KYC7MIAI (Aspartic Acid)
[Em] Mes de ingreso:1706
[Cu] Fecha actualización por clase:170620
[Lr] Fecha última revisión:170620
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:161228
[St] Status:MEDLINE
[do] DOI:10.1093/rheumatology/kew355


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[PMID]:28126186
[Au] Autor:Córdova ME; Pérez-Rojas DO; López-Marquet AD; Arenas R
[Ad] Dirección:Sección de Dermatología, Hospital Ángeles León, Guanajuato, México.
[Ti] Título:Exogenous Ochronosis in Facial Melasma.
[Ti] Título:Ocronosis exógena en melasma facial..
[So] Fuente:Actas Dermosifiliogr;108(4):381-383, 2017 May.
[Is] ISSN:1578-2190
[Cp] País de publicación:Spain
[La] Idioma:eng; spa
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1701
[Cu] Fecha actualización por clase:170501
[Lr] Fecha última revisión:170501
[St] Status:In-Data-Review


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[PMID]:27817975
[Au] Autor:Karaoglu S; Karaaslan F; Mermerkaya MU
[Ad] Dirección:Acibadem Kayseri Hospital, Kayseri, Turkey. Electronic address: sinankaraoglu@hotmail.com.
[Ti] Título:Long-term result of arthroplasty in the treatment of a case of ochronotic arthropathy.
[So] Fuente:Acta Orthop Traumatol Turc;50(5):584-586, 2016 Oct.
[Is] ISSN:1017-995X
[Cp] País de publicación:Turkey
[La] Idioma:eng
[Ab] Resumen:Alkaptonuria is a rare metabolic disease caused by a partial or total deficiency of homogentisic acid oxidase, which results in excess homogentisic acid (HGA) levels. Homogentisic acid and its oxidation products can accumulate in hyaline cartilage, tendons, and ligaments. A 55-year-old male was admitted complaining of worsening chronic pain in his left knee. A radiographic evaluation showed tricompartmental end- stage osteoarthritis. A cemented total knee replacement was performed. At the 10-year follow-up, he had returned to full activity, had no knee pain, and was very satisfied with the outcome. No abnormality was observed in the femoral, tibial, or patellar components on radiography. We believe that total knee replacement is a good option in a patient with marked degenerative arthritis secondary to ochronotic arthritis.
[Mh] Términos MeSH primario: Alcaptonuria/complicaciones
Artroplastia de Reemplazo de Rodilla/métodos
Ocronosis/complicaciones
Osteoartritis de la Rodilla/cirugía
[Mh] Términos MeSH secundario: Dolor Crónico/etiología
Ácido Homogentísico/orina
Humanos
Articulación de la Rodilla/cirugía
Masculino
Mediana Edad
Osteoartritis de la Rodilla/diagnóstico por imagen
Radiografía
Resultado del Tratamiento
[Pt] Tipo de publicación:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nombre de substancia:
NP8UE6VF08 (Homogentisic Acid)
[Em] Mes de ingreso:1702
[Cu] Fecha actualización por clase:170209
[Lr] Fecha última revisión:170209
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:161107
[St] Status:MEDLINE


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[PMID]:27740398
[Au] Autor:Rahimizadeh A; Soufiani H; Hassani V; Rahimizadeh A
[Ad] Dirección:Pars Advanced and Minimally Invasive Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran; and.
[Ti] Título:Symptomatic pseudarthrosis in ochronotic spine: case report.
[So] Fuente:J Neurosurg Spine;26(2):220-228, 2017 Feb.
[Is] ISSN:1547-5646
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:In this study the authors report the first example of spinal pseudarthrosis in a patient with ochronosis, and they describe the application of posterior-only 360° surgery as an alternative approach to combined anterior-posterior surgery in the management of pseudarthrosis of an ankylosed spine, regardless of its etiology. Spinal involvement in ochronosis produces loss of flexibility and ankylosis of thoracic and lumbar segments. Pseudarthrosis is a serious complication of the diseases that present with ankylosis of the spine. However, its occurrence in ochronotic spine has not been reported previously. Evaluation of progressive paraparesis in a 68-year-old man with ochronosis revealed pseudarthrosis at the T11-12 level. Circumferential dural sac decompression, debridement of the disc space, interbody fusion, and screw-rod fixation were all done via a posterior-only approach. Postoperatively the patient exhibited a marked recovery in terms of pain and neurological status. At the 3-month follow-up, he was able to walk independently. Ochronosis should be included in the etiology of pseudarthrosis. With aggravation of back pain and the appearance of neurological deficits in an already stable patient with any ankylosing disease, pseudarthrosis should be suspected. Furthermore, single-stage, 360°, posterior-only surgery may obviate the need for single-stage or staged anterior-posterior surgical intervention in patients with pseudarthrosis of the thoracic and lumbar spine.
[Mh] Términos MeSH primario: Ocronosis/complicaciones
Ocronosis/cirugía
Seudoartrosis/etiología
Seudoartrosis/cirugía
Vértebras Torácicas/cirugía
[Mh] Términos MeSH secundario: Anciano
Descompresión Quirúrgica/métodos
Diagnóstico Diferencial
Resultado Fatal
Humanos
Fijadores Internos
Masculino
Ocronosis/patología
Ocronosis/orina
Seudoartrosis/patología
Seudoartrosis/orina
Fusión Vertebral/métodos
Vértebras Torácicas/diagnóstico por imagen
[Pt] Tipo de publicación:CASE REPORTS; JOURNAL ARTICLE
[Em] Mes de ingreso:1702
[Cu] Fecha actualización por clase:170222
[Lr] Fecha última revisión:170222
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:161014
[St] Status:MEDLINE
[do] DOI:10.3171/2016.5.SPINE15671


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[PMID]:27207988
[Au] Autor:Jasper J; Metsaars W; Jansen J
[Ad] Dirección:Department of Orthopedics, Alrijne Ziekenhuis, Leiderdorp, The Netherlands.
[Ti] Título:Ochronosis of the knee with secondary osteoarthritis requiring total knee replacement in a patient with cryptogenic organising pneumonia.
[So] Fuente:BMJ Case Rep;2016, 2016 May 20.
[Is] ISSN:1757-790X
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Ochronosis is a rare autosomal recessive metabolic disease caused by homogentisic acid oxidase enzyme deficiency. High homogentisic acid levels will eventually result in black deposits in skin, sclerae, connective tissues and urine (alkaptonuria). It can lead to early degeneration of connective tissues and cartilage. Ochronosis can damage normal cartilage, leading to secondary osteoarthritis. The diagnosis is often delayed because of its low prevalence and non-specific early symptoms. In our patient, the secondary osteoarthritis due to ochronosis deposits in the cartilage was treated by total knee arthroplasty, with good clinical outcome. This article reports the first case of ochronosis with secondary osteoarthritis of the knee in a patient previously diagnosed with cryptogenic organising pneumonia (COP).
[Mh] Términos MeSH primario: Artroplastia de Reemplazo de Rodilla/métodos
Neumonía en Organización Criptogénica/complicaciones
Ocronosis/complicaciones
Osteoartritis de la Rodilla/diagnóstico por imagen
[Mh] Términos MeSH secundario: Femenino
Humanos
Mediana Edad
Osteoartritis de la Rodilla/etiología
Osteoartritis de la Rodilla/cirugía
Resultado del Tratamiento
[Pt] Tipo de publicación:CASE REPORTS; JOURNAL ARTICLE
[Em] Mes de ingreso:1701
[Cu] Fecha actualización por clase:170131
[Lr] Fecha última revisión:170131
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:160521
[St] Status:MEDLINE


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[PMID]:27197586
[Au] Autor:Zanwar A; Phatak S; Misra R
[Ad] Dirección:Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
[Ti] Título:Ochronosis.
[So] Fuente:Postgrad Med J;92(1092):626, 2016 Oct.
[Is] ISSN:1469-0756
[Cp] País de publicación:England
[La] Idioma:eng
[Mh] Términos MeSH primario: Alcaptonuria/diagnóstico por imagen
Calcinosis/diagnóstico por imagen
Disco Intervertebral/diagnóstico por imagen
Ocronosis/diagnóstico por imagen
Enfermedades de la Esclerótica
Enfermedades de la Columna Vertebral/diagnóstico por imagen
[Mh] Términos MeSH secundario: Alcaptonuria/orina
Humanos
Masculino
Mediana Edad
Ocronosis/orina
Radiografía
[Pt] Tipo de publicación:CASE REPORTS; JOURNAL ARTICLE
[Em] Mes de ingreso:1703
[Cu] Fecha actualización por clase:170322
[Lr] Fecha última revisión:170322
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:160924
[St] Status:MEDLINE
[do] DOI:10.1136/postgradmedj-2016-134174


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[PMID]:27026014
[Au] Autor:Cieszynski K; Podgórny J; Mostowska A; Jagodzinski PP; Grzegorzewska AE
[Ti] Título:Alkaptonuria: a disease with dark brown urine.
[So] Fuente:Pol Arch Med Wewn;126(4):284-5, 2016 Mar 29.
[Is] ISSN:1897-9483
[Cp] País de publicación:Poland
[La] Idioma:eng
[Mh] Términos MeSH primario: Alcaptonuria/complicaciones
Enfermedades de los Cartílagos/etiología
Homogentisato 1,2-Dioxigenasa/genética
Articulación de la Rodilla/cirugía
Ocronosis/etiología
[Mh] Términos MeSH secundario: Adulto
Alcaptonuria/genética
Alcaptonuria/metabolismo
Artroplastia de Reemplazo de Rodilla
Enfermedades de los Cartílagos/cirugía
Humanos
Masculino
Mediana Edad
Mutación
Ocronosis/complicaciones
Espondilosis/etiología
[Pt] Tipo de publicación:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nombre de substancia:
EC 1.13.11.5 (Homogentisate 1,2-Dioxygenase)
[Em] Mes de ingreso:1704
[Cu] Fecha actualización por clase:170407
[Lr] Fecha última revisión:170407
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:160430
[St] Status:MEDLINE
[do] DOI:10.20452/pamw.3355



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