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[PMID]: 23271002 [Au] Autor: Fan H; Qi D; Yang M; Fang H; Liu K; Zhao F [Ad] Dirección: School of Pharmacy, Yantai University, 264005 Yantai, Shandong, PR China. [Ti] Título: In vitro and in vivo anti-inflammatory effects of 4-methoxy-5- hydroxycanthin-6-one, a natural alkaloid from Picrasma quassioides. [So] Fuente: Phytomedicine;20(3-4):319-23, 2013 Feb 15. [Is] ISSN: 1618-095X [Cp] País de publicación: Germany [La] Idioma: eng [Ab] Resumen: In the present study, we evaluated the anti-inflammatory effect of 4-methoxy-5- hydroxycanthin-6-one (CAN), a natural alkaloid isolated from Picrasma quassioides. CAN significantly inhibited the production of NO and the release of TNF-α induced by LPS in macrophage RAW 264.7. Western blot showed that CAN can downregulate the expression of iNOS protein. After oral administration, CAN (3, 9, and 27 mg/kg) reduced the development of carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats. The observed results indicated that pre-treatment with CAN might be an effective therapeutic intervention against inflammatory diseases including chronic arthritis. [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mes de ingreso: 1302 [Sb] Subgrupo de revista: IM [St] Status: In-Process

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[PMID]: 23164762 [Au] Autor: Zhao W; Sun C; He J; Chen L; Zhang Y; Sun W [Ad] Dirección: Biomedicine Key Laboratory of Shaanxi Province, Northwest University, Xi'an 710069, PR China. [Ti] Título: The possible mechanisms of Picrasma quassiodes (D. Don) Benn. in the treatment of colitis induced by 2,4,6-trinitrobenzene sulfonic acid in mice. [So] Fuente: J Ethnopharmacol;145(2):424-30, 2013 Jan 30. [Is] ISSN: 1872-7573 [Cp] País de publicación: Ireland [La] Idioma: eng [Ab] Resumen: ETHNOPHARMACOLOGICAL RELEVANCE: Picrasma quassiodes (D. Don) Benn.(PQB) is used in folk medicines for the treatment of colds, upper respiratory infection, acute tonsillitis, acute gastroenteritis, bacillary dysentery and a variety of acute infectious diseases in Asia. Although recent reports indicate that PQB has antibacterial, and anti-inflammatory effects, its effects on colitis and its inhibitory mechanisms have not been previously reported. AIM OF THE STUDY: To assess the effects and the mode of action of the extract of Picrasma quassiodes (D. Don) Benn.(PQB) on a model of colitis in mice induced by trinitrobenzene sulfonic acid (TNBS). MATERIALS AND METHODS: We induced mice colitis using TNBS/ethanol, then different doses of Picrasma quassiodes (D. Don) Benn.(PQB) extract (100, 200 and 400 mg/kg/day) and sulfasalazine (500 mg/kg/day) were administered by gavage for 7 days after the induction of colitis. The mice body weight, colonic wet weight, colonic lengths, myeloperoxidase (MPO) activity, macroscopic and histological colon injury were observed. Pro-inflammatory cytokines such as: tumor necrosis factor-alpha (TNF-α) and interleukin-8 (IL-8) were assayed by enzyme-linked immunoassay. The protein expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in the colons were determined by immunohistochemical analysis. RESULTS: PQB administration effectively prevented mice diarrhea, decreasing of the body weights, shortening of colon length and increasing of colon wet weight. Macroscopic and histological examinations also indicated that it was protected against colonic edema, ulceration and MPO activity elevation. Furthermore, PQB inhibited the abnormal secretions of pro-inflammatory cytokines, such as TNF-α and IL-8. Additionally, administration of PQB effectively inhibited COX-2 and iNOS protein expression. CONCLUSIONS: These results suggest that PQB has an anti-inflammatory effect on TNBS-induced colitis due to the down-regulations of the productions and expressions of inflammatory mediators, and that it may be a potential inflammatory bowel disease (IBD) drug candidate. [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mes de ingreso: 1301 [Sb] Subgrupo de revista: IM [St] Status: In-Process

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[PMID]: 23142488 [Au] Autor: Zhao W; Yu J; Su Q; Liang J; Zhao L; Zhang Y; Sun W [Ad] Dirección: Biomedicine Key Laboratory of Shaanxi Province, Northwest University, Xi'an 710069, PR China. [Ti] Título: Antihypertensive effects of extract from Picrasma quassiodes (D. Don) Benn. in spontaneously hypertensive rats. [So] Fuente: J Ethnopharmacol;145(1):187-92, 2013 Jan 9. [Is] ISSN: 1872-7573 [Cp] País de publicación: Ireland [La] Idioma: eng [Ab] Resumen: UNLABELLED: ETHNOPHARMACOLOGICA RELEVANCE: Picrasma quassiodes (D. Don) Benn. (PQB) is a widely used herbal medicine used for gastroenteritis, snakebite, infection and hypertension in China. The aim of the study was to investigate the possible antihypertensive mechanisms on spontaneously hypertensive rats (SHR) of the extract from Picrasma quassiodes (D. Don) Benn. MATERIALS AND METHODS: In the in vivo study, extract from Picrasma quassiodes (D. Don) Benn. at the dose of 50, 100, 200mg/kg and captopril (12.5mg/kg) were administrated to different group of SHR rats by gavage for six consecutive weeks after the blood pressures were firstly measured. At the end of the study, rats serum nitric oxide (NO) was measured by the nitrate reductase method; superoxide dismutase (SOD) and malondialdehyde (MDA) activities were measured by the colorimetric method; the expression of aorta endothelial nitric oxide synthase (eNOS) was measured by immunohistochemical analysis. RESULTS: The results showed that the oral administration of PQB could lower the systolic blood pressure (SBP) of SHR rats. In addition, the serum level of NO in SHR treated with PQB (100 and 200mg/kg) was increased dramatically (P<0.05, P<0.01), but administration with captopril had no significant effect. The expression of aorta eNOS was markedly increased when treated with PQB. The serum SOD levels were increased with treatment of PQB (100 and 200mg/kg; P<0.05, P<0.01). All the effects of these parameters were comparable to that of the SHR control group. CONCLUSIONS: Our results disclosed that PQB is effective to lower blood pressure of SHR, its antihypertensive effect is probably associated with lowering oxidative stress by reducing SOD activity, preserving endothelial function and increasing the expression of eNOS to regulate NO and directly relax artery. [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mes de ingreso: 1212 [Sb] Subgrupo de revista: IM [St] Status: In-Process

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[PMID]: 23115019 [Au] Autor: Zhao F; Gao Z; Jiao W; Chen L; Chen L; Yao X [Ad] Dirección: School of Pharmacy, Yantai University, Yantai, PR China. zhaofeng74@yahoo.com.cn [Ti] Título: In vitro anti-inflammatory effects of beta-carboline alkaloids, isolated from Picrasma quassioides, through inhibition of the iNOS pathway. [So] Fuente: Planta Med;78(18):1906-11, 2012 Dec. [Is] ISSN: 1439-0221 [Cp] País de publicación: Germany [La] Idioma: eng [Ab] Resumen: In our previous study, fourty-eight compounds have been isolated and identified from the roots of Picrasma quassioides, which have been widely used as a traditional Chinese medicine for clearing heat and for detoxification as described in the Chinese Pharmacopoeia. ß-Carboline alkaloids are commonly considered as main active constituents of P. quassioides, but the molecular mechanism remains yet unknown. In the present paper, one new ß-carboline alkaloid together with two known ß-carboline alkaloids have been investigated for their anti-inflammatory effect and mechanism of action in cultured macrophage RAW 264.7 cells. Griess assay was used to evaluate the inhibitory effect on the overproduction of nitric oxide. ELISA was used to determine the level of proinflammatory cytokines including TNF-α and IL-6. The inhibitory effect on the enzymatic activity of COX-2 and inducible nitric oxide synthase were tested by colorimetric and fluorimetric methods, respectively. Western blot was used to detect the expression of inducible nitric oxide synthase and COX-2. All three ß-carboline alkaloids suppressed LPS-stimulated nitric oxide production and proinflammatory cytokines secretion, including TNF-α and IL-6 in a dose-dependent manner. They also strongly inhibited the expression of inducible nitric oxide synthase and inducible nitric oxide synthase enzymatic activity, whereas the expression of COX-2 and COX-2 enzymatic activity were not affected. These results indicated that potent inhibition of nitric oxide, TNF-α, and IL-6, but not COX-2 expression and COX-2 activity, might constitute the anti-inflammatory mechanism of ß-carboline alkaloids. ß-Carboline alkaloids suppressed the overproduction of nitric oxide through downregulation of inducible nitric oxide synthase expression and inducible nitric oxide synthase enzymatic activity in an LPS-stimulated macrophage. [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mes de ingreso: 1212 [Sb] Subgrupo de revista: IM [St] Status: In-Process [do] DOI: 10.1055/s-0032-1327883

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[PMID]: 22888096 [Au] Autor: Liao HJ; Lai ZQ; Su JY; Yi YY; Li YC; Lai XP; Su ZR; Lin ZX [Ad] Dirección: New Drug Research & Development Center, Guangzhou University of Chinese Medicine, Guangzhou, P. R. China. [Ti] Título: Fingerprinting and simultaneous determination of alkaloids in Picrasma quassioides from different locations by high performance liquid chromatography with photodiode array detection. [So] Fuente: J Sep Sci;35(17):2193-202, 2012 Sep. [Is] ISSN: 1615-9314 [Cp] País de publicación: Germany [La] Idioma: eng [Ab] Resumen: A simple and sensitive method was developed and validated for profiling and simultaneous quantitation of seven alkaloids (6-hydroxy-ß-carboline-1-carboxylic acid, ß-carboline-1-carboxylic acid, ß-carboline-1-propanoic acid, 3-methylcanthin-5,6-dione, 5-hydroxy-4-methoxycanthin-6-one, 1-methoxycarbony-ß-carboline, and 4,5-dimethoxycanthin-6-one) in Picrasma quassioide grown in different locations by high-performance liquid chromatography with photodiode array detection. The analysis was conducted on a Phenomenex Gemini C(18) column at 35°C with mobile phase of 25 mM aqueous ammonium acetate (pH 4.0, adjusted by glacial acetate acid) and acetonitrile. A common fingerprint chromatograph under 254 nm consisting of 27 peaks was constructed for the evaluation of the similarities among 31 P. quassioide samples. Samples from Guangdong and Guangxi Provinces were found to be within group linkage and showed significant difference from that of Jiangxi Province origin by using principal component analysis and hierarchical clustering analysis. In addition, the seven alkaloids were identified by electrospray ionization mass spectrometry and comparing with reference standards and literature data. All of them were determined simultaneously using the established HPLC method. This rapid and effective analytical method could be employed for quality assessment of P. quassioide, as well as pharmaceutical products containing this herbal material. [Mh] Términos MeSH primario: Alcaloides/análisis Cromatografía Líquida de Alta Presión/métodos Medicamentos Herbarios Chinos/análisis Picrasma/química [Mh] Términos MeSH secundario: China Cromatografía Líquida de Alta Presión/instrumentación Medicamentos Herbarios Chinos/normas Control de Calidad [Pt] Tipo de publicación: EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (Alkaloids); 0 (Drugs, Chinese Herbal) [Em] Mes de ingreso: 1301 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 120828 [St] Status: MEDLINE [do] DOI: 10.1002/jssc.201200025

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[PMID]: 22323133 [Au] Autor: Xiao X; Si X; Tong X; Li G [Ad] Dirección: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. [Ti] Título: Ultrasonic microwave-assisted extraction coupled with high-speed counter-current chromatography for the preparation of nigakinones from Picrasma quassioides (D.Don) Benn. [So] Fuente: Phytochem Anal;23(5):540-6, 2012 Sep-Oct. [Is] ISSN: 1099-1565 [Cp] País de publicación: England [La] Idioma: eng [Ab] Resumen: INTRODUCTION: Nigakinones are the main effective compounds of Picrasma quassioides (D. Don) Benn and are widely used in traditional Chinese medicine, therefore a rapid and efficient separation and purification method is necessary. OBJECTIVE: To develop a new method based on ultrasonic microwave-assisted extraction (UMAE) and high-speed counter-current chromatography (HSCCC) for the rapid separation and purification of nigakinone and methylnigakinone from P. quassioides (D.Don) Benn. METHODOLOGY: Response surface methodology (RSM) was used to optimise the extraction conditions of UMAE: 10.0 g of original sample was extracted with 210 mL of 90% (v/v) aqueous methanol at 60°C for 13 min, ultrasonic power was 100 W and microwave power was dynamically adjusted to the given temperature. After extraction, the extract was introduced into the HSCCC and separated with a hexane:ethyl acetate:methanol:2% acetic acid (9:11:9:11, v/v/v/v) solvent system. RESULTS: About 2.1 mg nigakinone with purity of 96.8% was obtained in one step within 200 min, methylnigakinone was also obtained with a purity of 75.6%. Their chemical structures were identified with ESI-MS and ¹H-NMR. CONCLUSION: UMAE coupled with HSCCC was found to be a promising and feasible alternative method to separate and purify alkaloids from natural herbs such as P. quassiodes. [Mh] Términos MeSH primario: Alcaloides/aislamiento & purificación Fraccionamiento Químico/métodos Distribución en Contracorriente/métodos Picrasma/química [Mh] Términos MeSH secundario: Alcaloides/química Fraccionamiento Químico/instrumentación Distribución en Contracorriente/instrumentación Medicamentos Herbarios Chinos/química Espectroscopía de Resonancia Magnética Microondas Solventes/química Espectrometría de Masa por Ionización de Electrospray Ultrasonido/instrumentación Ultrasonido/métodos [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (Alkaloids); 0 (Drugs, Chinese Herbal); 0 (Solvents) [Em] Mes de ingreso: 1212 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 120813 [St] Status: MEDLINE [do] DOI: 10.1002/pca.2352

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[PMID]: 21761728 [Au] Autor: Zhu C; Deng G; Lin C [Ad] Dirección: College of Chinese Traditional Medicine, Guangzhou University of Chinese Medicine Guangzhou Jianfeng Union Research Lab for Natural Products, Guangzhou 510006, China. [Ti] Título: [Study on chemical constituents of Picrasma quassioides]. [So] Fuente: Zhongguo Zhong Yao Za Zhi;36(7):886-90, 2011 Apr. [Is] ISSN: 1001-5302 [Cp] País de publicación: China [La] Idioma: chi [Ab] Resumen: To study the chemical constituents of Picrasma quassioides. The chemical constituents were isolated and purified by chromatographic methods over Sephadex LH-20 and silica gel column, and structurally elucidated by spectral analysis, including UV, IR, MS, 1H-NMR, 13C-NMR. Fourteen compounds were obtained and identified as trifolirhizin(1), maackiain(2), 3', 7-dihydroxy-4'-methoxylisoflavone(3), umbelliferone(4), emodin(5), nigakilactone F(6), picrasin B(7),picraqualide B (8),4-methoxy-5-hydroxycanthin-6-one(9), 4,5-dimethoxycanthin-6-one (10),5-methoxycanthin-6-one(11), 11-hydroxycanthin-6-one(12) , 1-methoxycarbonyl-beta-carboline(13), 1-hydroxymethyl-beta-carboline(14). Compounds 1-5 are reported from the first time for the genus Pricrasma. [Mh] Términos MeSH primario: Compuestos Orgánicos/análisis Picrasma/química [Mh] Términos MeSH secundario: Compuestos Orgánicos/aislamiento & purificación Análisis Espectral [Pt] Tipo de publicación: ENGLISH ABSTRACT; JOURNAL ARTICLE [Nm] Nombre de substancia: 0 (Organic Chemicals) [Em] Mes de ingreso: 1108 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 110718 [St] Status: MEDLINE

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[PMID]: 21674788 [Au] Autor: Jiao WH; Gao H; Zhao F; He F; Zhou GX; Yao XS [Ad] Dirección: College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China. [Ti] Título: A new neolignan and a new sesterterpenoid from the stems of Picrasma quassioides Bennet. [So] Fuente: Chem Biodivers;8(6):1163-9, 2011 Jun. [Is] ISSN: 1612-1880 [Cp] País de publicación: Switzerland [La] Idioma: eng [Ab] Resumen: A new dihydrobenzofuran-type neolignan, picrasmalignan A (1), and a new sesterterpene lactone, 2'-isopicrasin A (4), were isolated from the stems of Picrasma quassioides Bennet, along with four known compounds, comprising two neolignans, 2 and 3, a sesterterpene lactone, 5, and a flavonol, 6. The structures of these compounds were determined by detailed analysis of NMR and MS data, and comparison with the literature data. Compounds 1-6 were tested for their anti-inflammatory activity, and 1-3 and 6 showed potent inhibitory activities on nitric oxide, tumor necrosis factor-α, and interleukin-6 production in mouse monocyte-macrophage RAW 264.7 stimulated by lipopolysaccharide (LPS). [Mh] Términos MeSH primario: Antiinflamatorios/química Benzofuranos/química Lactonas/química Picrasma/química Sesterterpenos/química [Mh] Términos MeSH secundario: Animales Antiinflamatorios/aislamiento & purificación Antiinflamatorios/farmacología Benzofuranos/aislamiento & purificación Benzofuranos/farmacología Línea Celular Tumoral Interleucina-6/metabolismo Lactonas/aislamiento & purificación Lactonas/farmacología Lipopolisacáridos/toxicidad Macrófagos/efectos de drogas Ratones Óxido Nítrico/metabolismo Tallos de la Planta/química Sesterterpenos/aislamiento & purificación Sesterterpenos/farmacología Factor de Necrosis Tumoral alfa/metabolismo [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (2'-isopicrasin A); 0 (Anti-Inflammatory Agents); 0 (Benzofurans); 0 (Interleukin-6); 0 (Lactones); 0 (Lipopolysaccharides); 0 (Sesterterpenes); 0 (Tumor Necrosis Factor-alpha); 0 (picrasmalignan A); 10102-43-9 (Nitric Oxide) [Em] Mes de ingreso: 1110 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 110615 [St] Status: MEDLINE [do] DOI: 10.1002/cbdv.201000137

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[PMID]: 21372418 [Au] Autor: Jiao WH; Gao H; Zhao F; Lin HW; Pan YM; Zhou GX; Yao XS [Ad] Dirección: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China. [Ti] Título: Anti-inflammatory alkaloids from the stems of Picrasma quassioides BENNET. [So] Fuente: Chem Pharm Bull (Tokyo);59(3):359-64, 2011. [Is] ISSN: 1347-5223 [Cp] País de publicación: Japan [La] Idioma: eng [Ab] Resumen: During further chemical and biological investigations of Picrasma quassioides BENNET, four new bis-ß-carboline alkaloids, quassidines E-H (1-4), and three new ß-carboline alkaloids, canthin-16-one-14-butyric acid (5), 3-(1,1-dimethoxylmethyl)-ß-carboline (6), and 6,12-dimethoxy-3-formyl-ß-carboline (7), were isolated from its anti-inflammatory CHCl(3)-soluble fraction. Structures of new compounds were elucidated and characterized by MS and NMR analysis. A plausible biogenetic pathway for quassidine E (1), the first bis-ß-carboline alkaloid in which a canthin-6-one moiety and a ß-carboline moiety were connected together by a single carbon-carbon bond from the nature, was proposed. Quassidines E-G (1-3) showed potent inhibitory activity on the production of nitric oxide (NO), tumor necrosis factor α (TNF-α), or interleukin 6 (IL-6) in mouse monocyte-macrophage RAW264.7 cells stimulated by lipopolysaccharide (LPS). Analysis of anti-inflammatory activity of all ß-carboline and bis-ß-carboline alkaloids from P. quassioides showed that the carbonyl groups or double carbon-carbon bonds at C-14 for ß-carbolines and C-14' for bis-ß-carbolines were bioactive groups for their in vitro anti-inflammatory activity. Structure-activity relationship of these compounds on inhibitory activity of the three inflammatory cytokines was discussed. [Mh] Términos MeSH primario: Alcaloides/química Antiinflamatorios/química Picrasma/química [Mh] Términos MeSH secundario: Alcaloides/aislamiento & purificación Alcaloides/farmacología Animales Antiinflamatorios/aislamiento & purificación Antiinflamatorios/farmacología Línea Celular Tumoral Interleucina-6/antagonistas & inhibidores Interleucina-6/metabolismo Lipopolisacáridos/toxicidad Espectroscopía de Resonancia Magnética Ratones Conformación Molecular Óxido Nítrico/metabolismo Tallos de la Planta/química Relación Estructura-Actividad Factor de Necrosis Tumoral alfa/antagonistas & inhibidores Factor de Necrosis Tumoral alfa/metabolismo [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (Alkaloids); 0 (Anti-Inflammatory Agents); 0 (Interleukin-6); 0 (Lipopolysaccharides); 0 (Tumor Necrosis Factor-alpha); 10102-43-9 (Nitric Oxide) [Em] Mes de ingreso: 1106 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 110304 [St] Status: MEDLINE

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[PMID]: 20474029 [Au] Autor: Jiao WH; Gao H; Li CY; Zhou GX; Kitanaka S; Ohmura A; Yao XS [Ad] Dirección: College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China. [Ti] Título: Beta-carboline alkaloids from the stems of Picrasma quassioides. [So] Fuente: Magn Reson Chem;48(6):490-5, 2010 Jun. [Is] ISSN: 1097-458X [Cp] País de publicación: England [La] Idioma: eng [Ab] Resumen: Five new beta-carboline alkaloids, 6,12-dimethoxy-3-(2-hydroxylethyl)-beta-carboline (1), 3,10-dihydroxy-beta-carboline (2), 6,12-dimethoxy-3-(1-hydroxylethyl)-beta-carboline (3), 6,12-dimethoxy-3-(1,2-dihydroxylethyl)-beta-carboline (4), and 6-methoxy-3-(2-hydroxyl-1-ethoxylethyl)-beta-carboline (5), and two new natural products, 6-methoxy-12-hydroxy-3-methoxycarbonyl-beta-carboline (6) and 3-hydroxy-beta-carboline (7) were isolated from the stems of Picrasma quassioides along with 16 known beta-carboline alkaloids (8-23). The structures of new compounds were determined by extensive spectroscopic analyses, and the 1D and 2D NMR data of compounds 6, 7 and 10 were reported for the first time. The bioassays showed that only compounds 14 and 16 could enhance the differentiation of 3T3-L1 preadiocytes accompanied by secretion of adiponectin proteins among these 23 compounds. [Mh] Términos MeSH primario: Alcaloides/química Carbolinas/química Espectroscopía de Resonancia Magnética/métodos Picrasma/química Extractos Vegetales/química Tallos de la Planta/química [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (Alkaloids); 0 (Carbolines); 0 (Plant Extracts) [Em] Mes de ingreso: 1009 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 100517 [St] Status: MEDLINE [do] DOI: 10.1002/mrc.2602

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