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[PMID]: 22470772 [Au] Autor: Parsian S; Rahbar H; Rendi MH; Lehman CD [Ad] Dirección: Department of Radiology, University of Washington, Seattle, WA 98109, USA. parsian@u.washington.edu [Ti] Título: Benign breast cyst without associated gynecomastia in a male patient: a case report. [So] Fuente: J Radiol Case Rep;5(11):35-40, 2011. [Is] ISSN: 1943-0922 [Cp] País de publicación: Unknown [La] Idioma: eng [Ab] Resumen: Benign simple breast cysts are commonly seen in female breasts and can present as palpable masses. They are distinctly uncommon, however, in the male breast. We report a case of simple benign cyst of the breast in a 58-year-old man newly diagnosed with mantel cell lymphoma. The cyst was first identified incidentally on a staging contrast-enhanced chest computed tomography. Further evaluation with mammography and ultrasound revealed a mass that would be typically characterized as a benign simple cyst, but was biopsied since cysts are not known to occur in male breasts. Pathology results from ultrasound-guided core needle biopsy revealed benign cyst and focal fibrosis which was concordant with the imaging findings. In this case report, we will briefly discuss breast cysts in men and their imaging features including mammography and ultrasound. [Mh] Términos MeSH primario: Quiste Mamario/diagnóstico [Mh] Términos MeSH secundario: Mama/patología Diagnóstico Diferencial Humanos Biopsia Guiada por Imagen Masculino Mamografía Mediana Edad Fotomicrografía Ultrasonografía Mamaria [Pt] Tipo de publicación: CASE REPORTS; JOURNAL ARTICLE [Em] Mes de ingreso: 1211 [Cu] Fecha actualización por clase: 130529 [Lr] Fecha última revisión: 130529 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 120403 [St] Status: MEDLINE [do] DOI: 10.3941/jrcr.v5i11.869

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[PMID]: 22812679 [Au] Autor: Han W; Kim H; Ku SY; Kim SH; Choi YM; Kim JG; Moon SY [Ad] Dirección: Department of Surgery, Seoul National University College of Medicine, Seoul, Korea. [Ti] Título: Ovarian cysts during tamoxifen use may affect the prognostic markers of premenopausal breast cancer. [So] Fuente: Gynecol Endocrinol;29(1):16-9, 2013 Jan. [Is] ISSN: 1473-0766 [Cp] País de publicación: England [La] Idioma: eng [Ab] Resumen: OBJECTIVES: Only a few studies have suggested the association between ovarian cysts and serum estrogen levels during tamoxifen use. However, increased estrogen levels with ovarian cysts would affect the prognosis of breast cancer; this association has not yet been studied. We aimed to investigate the association between ovarian cysts and prognostic markers in premenopausal breast cancer patients undergoing tamoxifen treatment. METHODS: A retrospective review of 65 premenopausal breast cancer patients who underwent tamoxifen treatment was performed. Serum hormone levels were measured either specifically between cycle days 2 and 5 in menstruating patients or at any time in amenorrheic participants. RESULTS: The study population consisted of premenopausal patients with (n = 23) and without ovarian cysts (n = 42). Serum estradiol (E(2)) levels and tumor markers were not statistically different based on ovarian cyst status. In the subgroup analysis, serum E(2) levels were significantly higher in menstruating women with ovarian cysts, and E(2) levels were positively correlated with serum cancer antigen 15-3 and insulin-like growth factor-1 in these women. CONCLUSIONS: Ovarian cysts during tamoxifen use may affect the markers associated with the clinical course of premenopausal breast cancer. [Mh] Términos MeSH primario: Neoplasias de la Mama/sangre Neoplasias de la Mama/quimioterapia Quistes Ováricos/sangre Quistes Ováricos/inducido químicamente Premenopausia/sangre Tamoxifeno/efectos adversos [Mh] Términos MeSH secundario: Adulto Amenorrea/sangre Antineoplásicos Hormonales/administración & dosificación Antineoplásicos Hormonales/efectos adversos Estradiol/sangre Femenino Humanos Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina/sangre Factor I del Crecimiento Similar a la Insulina/metabolismo Menstruación/sangre Mediana Edad Mucina-1/sangre Pronóstico Estudios Retrospectivos Tamoxifeno/administración & dosificación Marcadores Biológicos de Tumor/sangre [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (Antineoplastic Agents, Hormonal); 0 (IGFBP3 protein, human); 0 (Insulin-Like Growth Factor Binding Protein 3); 0 (Mucin-1); 0 (Tumor Markers, Biological); 10540-29-1 (Tamoxifen); 50-28-2 (Estradiol); 67763-96-6 (Insulin-Like Growth Factor I) [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 121129 [St] Status: MEDLINE [do] DOI: 10.3109/09513590.2012.705374

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[PMID]: 23009559 [Au] Autor: Accurso A; Pettinato G; Ciancia G; Bellevicine C; Riccardi A; Rocco N [Ad] Dirección: Department of General, Geriatric, Oncologic Surgery and Advanced Technologies, Faculty of Medicine and Surgery, University Federico II of Naples, Via S. Pansini 5, 80131 Naples, Italy. [Ti] Título: Pure primary squamous cell carcinoma of the breast presenting as an intracystic tumor. [So] Fuente: Breast J;18(6):608-9, 2012 Nov-Dec. [Is] ISSN: 1524-4741 [Cp] País de publicación: United States [La] Idioma: eng [Mh] Términos MeSH primario: Quiste Mamario/patología Neoplasias de la Mama/patología Carcinoma de Células Escamosas/patología [Mh] Términos MeSH secundario: Adulto Biopsia con Aguja Fina Quiste Mamario/ultrasonografía Neoplasias de la Mama/radiografía Carcinoma de Células Escamosas/radiografía Femenino Humanos Mamografía [Pt] Tipo de publicación: CASE REPORTS; JOURNAL ARTICLE [Em] Mes de ingreso: 1304 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 121106 [St] Status: MEDLINE [do] DOI: 10.1111/tbj.12017

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[PMID]: 23002953 [Au] Autor: King V; Kaplan J; Pike MC; Liberman L; David Dershaw D; Lee CH; Brooks JD; Morris EA [Ad] Dirección: Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. kingv@mskcc.org [Ti] Título: Impact of tamoxifen on amount of fibroglandular tissue, background parenchymal enhancement, and cysts on breast magnetic resonance imaging. [So] Fuente: Breast J;18(6):527-34, 2012 Nov-Dec. [Is] ISSN: 1524-4741 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: The objective of this study was to evaluate the impact of tamoxifen treatment on amount of fibroglandular tissue (FGT), background parenchymal enhancement (BPE), and cysts on breast MRI. Retrospective search identified 96 women with breast cancer who had a breast MRI both before and during adjuvant tamoxifen therapy between 2002 and 2008. After exclusion of all irradiated breasts, 88 women were eligible. Two readers blinded to tamoxifen treatment status independently rated level of BPE, amount of FGT, and cysts using a 4-point categorical scale: BPE--Minimal, Mild, Moderate, Marked; FGT--Fatty, Scattered, Heterogeneously Dense (HD), Dense; Cysts--Minimal, Mild, Moderate, Marked. A consensus interpretation was reached in cases of disagreement. During tamoxifen, there was a significant shift from higher to lower degree BPE, cysts, and FGT compared with before tamoxifen. BPE, cysts and FGT decreased in 68% (60/88), 38% (33/88), and 40% (35/88) of women during tamoxifen (p<0.001 for all measures). After the exclusion of all cases with minimal BPE, cysts, or FGT on the pre-tamoxifen MRI, the percentage of women demonstrating a decrease in these factors increased to 81% (60/74), 77% (33/43), and 41% (35/86), respectively. Exclusion of patients treated with chemotherapy did not substantially change these results. The percentage of women with decreases in FGT and cysts increased with greater duration on tamoxifen, whereas decreases in BPE were detected early in treatment (<90 days) and did not change substantially with longer duration on tamoxifen. A significant association exists between treatment with tamoxifen and decreases in BPE, cysts, and FGT on breast MRI. [Mh] Términos MeSH primario: Antineoplásicos Hormonales/uso terapéutico Quiste Mamario/diagnóstico Quiste Mamario/patología Neoplasias de la Mama/quimioterapia Neoplasias de la Mama/patología Imagen por Resonancia Magnética/métodos Tamoxifeno/uso terapéutico [Mh] Términos MeSH secundario: Adulto Anciano Quiste Mamario/quimioterapia Quimioterapia Adyuvante Femenino Humanos Mediana Edad Estudios Retrospectivos Resultado del Tratamiento Adulto Joven [Pt] Tipo de publicación: CLINICAL TRIAL; JOURNAL ARTICLE [Nm] Nombre de substancia: 0 (Antineoplastic Agents, Hormonal); 10540-29-1 (Tamoxifen) [Em] Mes de ingreso: 1304 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 121106 [St] Status: MEDLINE [do] DOI: 10.1111/tbj.12002

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[PMID]: 22845618 [Au] Autor: Sanders LM; Lacz NL; Lara J [Ad] Dirección: Medical Director, Breast Center at the Ambulatory Care Center of Barnabas Health, Livingston, New Jersey 07039, USA. lmsand@optonline.net [Ti] Título: 16 year experience with aspiration of noncomplex breast cysts: cytology results with focus on positive cases. [So] Fuente: Breast J;18(5):443-52, 2012 Sep. [Is] ISSN: 1524-4741 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: We performed a retrospective review of 5375 aspirations performed during the last 16 years of noncomplex cysts. Cytology results and outcomes following aspirations of simple and complicated cysts performed by the senior author at our institution were reviewed. Complex cysts with associated solid components which were core biopsied are excluded from this review. We present our data as the largest series to date performed by one breast radiologist at a single institution. Our data separate cysts with atypia or malignant cytology into those sampled concurrently with solid neoplasms and those which were isolated lesions. Various technical issues which have not been previously addressed in the literature are discussed. Noncomplex cysts are benign 99% of the time. Cysts with papillary cytology require no further workup. Margin-negative seromas do not require cytologic analysis of fluid. Sixteen malignancies were revealed (0.3%), eight of which were solitary cysts (0.1%). Atypical cytology predicted malignancy in 21%; therefore, atypical cytology requires further workup. Malignant cytology was associated with breast cancer in 90.9% of patients; therefore, all patients with malignant cytology require biopsy. [Mh] Términos MeSH primario: Biopsia con Aguja/métodos Quiste Mamario/patología Neoplasias de la Mama/patología [Mh] Términos MeSH secundario: Adulto Anciano Anciano de 80 o más Años Femenino Humanos Mediana Edad Estudios Retrospectivos [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1304 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 120910 [St] Status: MEDLINE [do] DOI: 10.1111/j.1524-4741.2012.01277.x

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[PMID]: 23340752 [Au] Autor: Morello L; Martin TJ [Ti] Título: Hypertension and ventricular tachycardia with perioperative use of Vick's Vapor InhalerR. [So] Fuente: Anesth Analg;116(2):506-7, 2013 Feb. [Is] ISSN: 1526-7598 [Cp] País de publicación: United States [La] Idioma: eng [Mh] Términos MeSH primario: Hipertensión/inducido químicamente Metanfetamina/efectos adversos Descongestionantes Nasales/efectos adversos Taquicardia Ventricular/inducido químicamente [Mh] Términos MeSH secundario: Administración por Inhalación Quiste Mamario/cirugía Femenino Humanos Metanfetamina/administración & dosificación Mediana Edad Descongestionantes Nasales/administración & dosificación [Pt] Tipo de publicación: LETTER [Nm] Nombre de substancia: 0 (Nasal Decongestants); 537-46-2 (Methamphetamine) [Em] Mes de ingreso: 1303 [Sb] Subgrupo de revista: AIM; IM [Da] Fecha de ingreso para procesamiento: 130123 [St] Status: MEDLINE [do] DOI: 10.1213/ANE.0b013e3182798986

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[PMID]: 23152464 [Au] Autor: Ponka D; Baddar F [Ad] Dirección: Department of Family Medicine, University of Ottawa, Ontario. [Ti] Título: Breast cyst aspiration. [So] Fuente: Can Fam Physician;58(11):1240, 2012 Nov. [Is] ISSN: 1715-5258 [Cp] País de publicación: Canada [La] Idioma: eng [Mh] Términos MeSH primario: Quiste Mamario/terapia Agujas Succión/métodos [Mh] Términos MeSH secundario: Anestésicos Locales/uso terapéutico Quiste Mamario/diagnóstico Líquido Quístico Femenino Humanos Lidocaína/uso terapéutico Jeringas [Pt] Tipo de publicación: JOURNAL ARTICLE [Nm] Nombre de substancia: 0 (Anesthetics, Local); 137-58-6 (Lidocaine) [Em] Mes de ingreso: 1303 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 121115 [St] Status: MEDLINE

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[PMID]: 22723042 [Au] Autor: Hahn M; Krainick-Strobel U; Toellner T; Gissler J; Kluge S; Krapfl E; Peisker U; Duda V; Degenhardt F; Sinn HP; Wallwiener D; Gruber IV; Minimally Invasive Breast Intervention Study Group (AG MiMi) of the German Society of Senology (DGS); Study Group for Breast Ultrasonography of the German Society for Ultrasound in Medicine (DEGUM) [Ad] Dirección: Department of Obstetrics and Gynaecology, University Hospital Tuebingen. markus.hahn@med.unituebingen.de [Ti] Título: Interdisciplinary consensus recommendations for the use of vacuum-assisted breast biopsy under sonographic guidance: first update 2012. [So] Fuente: Ultraschall Med;33(4):366-71, 2012 Aug. [Is] ISSN: 1438-8782 [Cp] País de publicación: Germany [La] Idioma: eng [Ab] Resumen: PURPOSE: The vacuum biopsy of the breast under sonographic guidance (VB) was introduced in Germany in the year 2000 and the first consensus recommendations were published by Krainick-Strobel et al. in 2005. Since then, many clinical studies on this technique have been published. The purpose of this publication is to update the consensus recommendations from 2005 regarding the latest literature. MATERIALS AND METHODS: The consensus statements were the result of two preliminary meetings after the review of the latest literature by members of the Minimally Invasive Breast Intervention Study Group from the German Society of Senology. The final consensus text was review by all members of the working group. The statements listed under results obtained complete acceptance (consensus 100 %). RESULTS: The consensus recommendations describe the indications, investigator qualifications, technical requirements, documentation, quality assurance and follow-up intervals regarding the latest literature. CONCLUSION: The VB is a safe method for extracting breast tissue for histological workup. The technique allows the resection of breast tissue up to 8 cm3. Besides the diagnostic indications, the method qualifies for a therapeutic resection of symptomatic benign lesions (e. g. fibroadenomas). The technique should be used in specialized breast centers working in a multidisciplinary setup. This paper is an expert's recommendation for the use of VB under sonographic guidance. It is not formulated as a nationwide guideline. [Mh] Términos MeSH primario: Neoplasias de la Mama/patología Neoplasias de la Mama/ultrasonografía Conducta Cooperativa Biopsia Guiada por Imagen/métodos Comunicación Interdisciplinaria Ultrasonografía Intervencional/métodos Ultrasonografía Mamaria/métodos [Mh] Términos MeSH secundario: Quiste Mamario/patología Quiste Mamario/cirugía Quiste Mamario/ultrasonografía Neoplasias de la Mama/cirugía Calcinosis/patología Calcinosis/cirugía Calcinosis/ultrasonografía Carcinoma Intraductal no Infiltrante/patología Carcinoma Intraductal no Infiltrante/cirugía Carcinoma Intraductal no Infiltrante/ultrasonografía Carcinoma Lobular/patología Carcinoma Lobular/ultrasonografía Fibroadenoma/patología Fibroadenoma/cirugía Fibroadenoma/ultrasonografía Humanos Mamografía Grupo de Atención al Paciente Lesiones Precancerosas/patología Lesiones Precancerosas/cirugía Lesiones Precancerosas/ultrasonografía Garantía de la Calidad de Atención de Salud/métodos Cirugía Asistida por Computador/métodos Procedimientos Quirúrgicos Mínimamente Invasivos/métodos Vacio [Pt] Tipo de publicación: CONSENSUS DEVELOPMENT CONFERENCE; JOURNAL ARTICLE; PRACTICE GUIDELINE [Em] Mes de ingreso: 1303 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 120808 [St] Status: MEDLINE

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[PMID]: 23233684 [Au] Autor: Bick BL; Haji S; Laughlin RS; Watson RE; Kumar N [Ti] Título: Metastatic breast cancer suggesting parasitic disease. [So] Fuente: Neurology;79(24):2366, 2012 Dec 11. [Is] ISSN: 1526-632X [Cp] País de publicación: United States [La] Idioma: eng [Mh] Términos MeSH primario: Adenocarcinoma/secundario Neoplasias Encefálicas/secundario Neoplasias de la Mama/patología Equinococosis/patología Neurocisticercosis/patología [Mh] Términos MeSH secundario: Diagnóstico Diferencial Femenino Humanos Imagen por Resonancia Magnética Mediana Edad [Pt] Tipo de publicación: CASE REPORTS; JOURNAL ARTICLE [Em] Mes de ingreso: 1302 [Sb] Subgrupo de revista: AIM; IM [Da] Fecha de ingreso para procesamiento: 121212 [St] Status: MEDLINE [do] DOI: 10.1212/WNL.0b013e318278b696

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[PMID]: 22030022 [Au] Autor: Kotb AM; Hierholzer A; Kemler R [Ad] Dirección: Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, D-79108 Freiburg, Germany. [Ti] Título: Replacement of E-cadherin by N-cadherin in the mammary gland leads to fibrocystic changes and tumor formation. [So] Fuente: Breast Cancer Res;13(5):R104, 2011. [Is] ISSN: 1465-542X [Cp] País de publicación: England [La] Idioma: eng [Ab] Resumen: INTRODUCTION: E-cadherin (E-cad; cadherin 1) and N-cadherin (N-cad; cadherin 2) are the most prominent members of the cadherin family of cell adhesion molecules. Although they share many structural and functional features, they are expressed in an almost mutually exclusive manner in vivo. METHODS: To explore functional differences between the two cadherins in vivo, we recently generated a knock-in line in which N-cad is expressed from the E-cad locus. In combination with a conditional gene inactivation approach, we expressed N-cad in the absence of E-cad (referred to as Ncadk.i.) in alveolar epithelial cells of the mammary gland starting in late pregnancy. RESULTS: We found that the sole presence of N-cad induces constitutively active fibroblast growth factor (Fgf) signaling and a precocious involution resulting in massive apoptosis of alveolar cells. To block apoptosis, we conditionally deleted one allele of p53 in Ncadk.i. mice and observed a temporal rescue of alveolar morphology and function. However, an accumulation of fibrotic tissue and cysts with increasing age and lactation cycles was observed. This phenotype closely resembled fibrocystic mastopathy (FM), a common disorder in humans, which is thought to precede breast cancer. Concordantly, 55% of Ncadk.i. mice harboring a heterozygous p53 deletion developed malignant and invasive tumors. CONCLUSIONS: Our results demonstrate a possible role for N-cad in the formation of fibrosis and cysts in the mammary gland. Moreover, we show that these lesions precede the development of malignant tumors. Thus, we provide a new mouse model to investigate the molecular mechanisms of fibrocystic mastopathy and the transition from benign to malignant tumors. [Mh] Términos MeSH primario: Quiste Mamario/genética Cadherinas/genética Glándulas Mamarias Animales/patología [Mh] Términos MeSH secundario: Factores de Edad Animales Apoptosis/genética Quiste Mamario/patología Cadherinas/metabolismo Movimiento Celular/genética Células Epiteliales/metabolismo Células Epiteliales/patología Transición Epitelial-Mesenquimal/genética Femenino Factores de Crecimiento de Fibroblastos/metabolismo Enfermedad Fibroquística de la Mama/genética Enfermedad Fibroquística de la Mama/patología Fibrosis/genética Silenciador del Gen Genes p53 Lactancia/genética Glándulas Mamarias Animales/citología Glándulas Mamarias Animales/metabolismo Neoplasias Mamarias Animales/genética Neoplasias Mamarias Animales/patología Ratones Ratones Transgénicos Embarazo [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nombre de substancia: 0 (Cadherins); 0 (Cdh2 protein, mouse); 62031-54-3 (Fibroblast Growth Factors) [Em] Mes de ingreso: 1212 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 120427 [St] Status: MEDLINE [do] DOI: 10.1186/bcr3046

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