| [PMID]: | 22584733 |
| [Au] Autor: | Shimozuma K; Ohashi Y; Takeuchi A; Aranishi T; Morita S; Kuroi K; Ohsumi S; Makino H; Katsumata N; Kuranami M; Suemasu K; Watanabe T; Hausheer FH |
| [Ad] Dirección: | Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga 525-8577, Japan. k-shimoz@sk.ritsumei.ac.jp |
| [Ti] Título: | Taxane-induced peripheral neuropathy and health-related quality of life in postoperative breast cancer patients undergoing adjuvant chemotherapy: N-SAS BC 02, a randomized clinical trial. |
| [So] Fuente: | Support Care Cancer;20(12):3355-64, 2012 Dec. |
| [Is] ISSN: | 1433-7339 |
| [Cp] País de publicación: | Germany |
| [La] Idioma: | eng |
| [Ab] Resumen: | PURPOSE: To elucidate whether adjuvant taxane monotherapy is a feasible and tolerable for postoperative breast cancer patients, we evaluated the severity of chemotherapy-induced peripheral neuropathy (CIPN) and the relative tolerability of regimens by health-related quality of life (HRQOL) assessment in node-positive breast cancer patients treated with taxane-containing regimens. METHODS: We evaluated CIPN and HRQOL in the first 300 patients enrolled in a larger (1,060 total) multicenter phase III trial randomized to one of four adjuvant regimens: (1) anthracycline-cyclophosphamide followed by paclitaxel (ACP), (2) AC followed by docetaxel (ACD), (3) paclitaxel alone (PTX), or (4) docetaxel alone (DTX). CIPN was assessed by the Patient Neurotoxicity Questionnaire (PNQ) and the National Cancer Institute Common Toxicity Criteria, and HRQOL by Functional Assessment of Cancer Therapy-General (FACT-G). CIPN and HRQOL scores were compared between ACP and ACD vs. PTX and DTX, and ACP and PTX vs. ACD and DTX. RESULTS: PNQ sensory scores were significantly higher in patients treated with taxane monotherapy compared to treatment with AC followed by taxane (P = .003). No significant differences in PNQ sensory scores were observed between the ACP and PTX vs. ACD and DTX regimens (P = .669). Regardless of taxane regimen, PNQ severity scores for CIPN appear to be largely reversible within 1 year of adjuvant treatment. No significant difference in FACT-G scores was observed between any regimens during the study treatments. CONCLUSIONS: Patient-reported CIPN was significantly more severe with single-agent adjuvant taxane compared to AC followed by taxane treatment; however, the HRQOL findings support that single-agent taxane treatment is tolerable. |
| [Mh] Términos MeSH primario: |
Antineoplásicos/efectos adversos
Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos
Neoplasias de la Mama/quimioterapia
Síndromes de Neurotoxicidad
Enfermedades del Sistema Nervioso Periférico/inducido químicamente
Taxoides/efectos adversos
|
| [Mh] Términos MeSH secundario: |
Adulto
Anciano
Neoplasias de la Mama/cirugía
Quimioterapia Adyuvante
Ensayos Clínicos Fase II como Asunto
Femenino
Humanos
Mediana Edad
Paclitaxel/efectos adversos
Parestesia/inducido químicamente
Calidad de Vida
Cuestionarios
|
| [Pt] Tipo de publicación: | JOURNAL ARTICLE; MULTICENTER STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T |
[Nm] Nombre de substancia:
| 0 (Antineoplastic Agents); 0 (Taxoids); 114977-28-5 (docetaxel); 33069-62-4 (Paclitaxel) |
| [Em] Mes de ingreso: | 1305 |
| [Sb] Subgrupo de revista: | IM |
| [Da] Fecha de ingreso para procesamiento: | 121025 |
| [St] Status: | MEDLINE |
| [do] DOI: | 10.1007/s00520-012-1492-x |
