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[PMID]:29393404
[Au] Autor:Tong JB; Zhang XX; Wang XH; Zeng SJ; Wang DY; Zhang ZQ; Hu J; Yang C; Li ZG
[Ad] Dirección:Department of Respiratory, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230031, P.R. China.
[Ti] Título:Qiyusanlong decoction suppresses lung cancer in mice via Wnt/ß-catenin pathway.
[So] Fuente:Mol Med Rep;17(4):5320-5327, 2018 Apr.
[Is] ISSN:1791-3004
[Cp] País de publicación:Greece
[La] Idioma:eng
[Ab] Resumen:Lung cancer is one of the most fatal cancers due to its high metastatic rate. Traditional Chinese medicine has been used in cancer patients for decades to improve quality of life and prolong survival time. The present study used a novel Qiyusanlong (QYSL) decoction composed of 10 kinds of Chinese medicine including astragalus membranaceus (Huangqi), polygonatumod oratum (yuzu), scolopendra (tianlong), pberetima (dilong), solanum nigrum (longkui), herbahedyotis (baihushecao), semen coicis (yiyiren), euphorbia helioscopia (zeqi), curcuma longa (eshu) and tendril-leaved fritillary bulb (chuanbei). The effects and function of the QYSL decoction remain to be elucidated. The present study established a mouse xenograft model using Lewis lung carcinoma cell injection and administered different doses of QYSL decoction to the mice. It was demonstrated that the chemotherapy drug Cisplatin (DDP) and QYSL decoction repressed lung tumor growth, and the inhibitory effect of DDP was more significant. Furthermore, QYSL decoction and DDP modulated the expression of regulatory proteins in the Wnt/ß­catenin pathway, including Wnt1, Wnt2, Wnt5a and glycogen synthase kinase 3ß, detected by western blotting, and affected the signals of cluster of differentiation 44 variation 6 and Survivin in tumor tissues, examined via immunohistochemistry. The combination of QYSL decoction and DDP enhanced the inhibitory effect. These data demonstrated that the QYSL decoction repressed lung tumor development via the Wnt/ß­catenin pathway. The therapeutic effect of QYSL decoction alone was milder compared with DDP, however the combination of QYSL decoction and chemotherapy exhibited an increased the rapeutic effect compared with the treatments administered alone. These findings revealed the function of QYSL decoction as a lung cancer treatment and provided insight for a novel lung cancer therapy.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[St] Status:In-Process
[do] DOI:10.3892/mmr.2018.8478


  2 / 413 MEDLINE  
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[PMID]:29421515
[Au] Autor:Xiang L; Wang Y; Yi X; He X
[Ad] Dirección:School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou 510006, China.
[Ti] Título:Anti-inflammatory steroidal glycosides from the berries of Solanum nigrum L. (European black nightshade).
[So] Fuente:Phytochemistry;148:87-96, 2018 Apr.
[Is] ISSN:1873-3700
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Seven previously undescribed steroidal glycosides, along with three known congeners were isolated from the unripe berries of Solanum nigrum L. (Solanaceae). Their structures were elucidated on basis of 1D and 2D NMR, HR-ESI-MS spectroscopic data and GC analysis after acid hydrolysis. The potential inhibitory effects on nitric oxide (NO) production induced by lipopolysaccharide in RAW 264.7 cell line and the anti-proliferative activities against five cancer cell lines (HL-60, U-937, Jurkat, K562 and HepG2) were evaluated. Seven compounds exhibited inhibition activities on NO production with IC values ranging from 11.33 to 49.35 µM. Structure-activity relationships of the isolated compounds were also discussed.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180302
[Lr] Fecha última revisión:180302
[St] Status:In-Process


  3 / 413 MEDLINE  
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[PMID]:29453917
[Au] Autor:Hameed A; Akhtar N
[Ad] Dirección:1Faculty of Pharmacy and Alternative Medicine The Islamia University of Bahawalpur 63100, Pakistan.
[Ti] Título:Comparative chemical investigation and evaluation of antioxidant and tyrosinase inhibitory effects of Withania somnifera (L.) Dunal and Solanum nigrum (L.) berries.
[So] Fuente:Acta Pharm;68(1):47-60, 2018 Mar 01.
[Is] ISSN:1846-9558
[Cp] País de publicación:Croatia
[La] Idioma:eng
[Ab] Resumen:In the present study, berries of two different species of Solanaceae family, Withania somnifera (WS) and Solanum nigrum (SN), were extracted in methanol and then fractionated with solvents, ranging from non-polar to polar, for their phytochemical profiling and investigation of antioxidant and tyrosinase enzyme inhibition capacity. The methanolic extract and n-hexane, ethyl acetate (WSEA, SNEA) and aqueous fractions were chemically analyzed and evaluated for biological activity. Total flavonoids and total phenolics were quantified in WSEA (96.91 ± 1.56 µg QE mg-1 sample and 178.45 ± 2.78 µg GAE mg-1 s ample, r esp.) and S NEA (89.58 ± 0.98 µg QE mg-1 sample and 120.15 ± 2.33 µg GAE mg-1 sample, resp.). HPLC-DAD analysis of ethyl acetate fractions of WS and SN measured 13.74 and 5.34 µg GAE mg-1 dry fraction and 3.72 and 3.41 µg QE mg-1 dry fraction, resp. WSEA and SNEA fractions showed the highest 2,2-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, total antioxidant capacity and iron reducing power activity. The highest inhibition of tyrosinase enzyme was also exhibited by WSEA and SNEA (59.6 and 58.7 %) resp. This investigation justifies the medicinal value of W. somnifera and S. nigrum berry extracts as potential and readily available sources of natural antioxidants. Marked tyrosinase enzyme inhibition activity and antioxidant activity of both plant extracts might be due to polyphenols and flavonoids.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180217
[Lr] Fecha última revisión:180217
[St] Status:In-Process


  4 / 413 MEDLINE  
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[PMID]:29433104
[Au] Autor:Wei R; Guo Q; Yu G; Kong J; Li S; Song Z; Hu J; Tian L; Han X; Okoli CP
[Ad] Dirección:Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, China.
[Ti] Título:Stable isotope fractionation during uptake and translocation of cadmium by tolerant Ricinus communis and hyperaccumulator Solanum nigrum as influenced by EDTA.
[So] Fuente:Environ Pollut;236:634-644, 2018 Feb 09.
[Is] ISSN:1873-6424
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:The isotopic fractionation could contribute to understanding the Cd accumulation mechanisms in plant species. However, there are few of systematical investigations with regards to the Cd isotope fractionation in hyperaccumulator plants. The Cd tolerant Ricinus communis and hyperaccumulator Solanum nigrum were cultivated in nutrient solutions with varying Cd and EDTA concentrations. Cd isotope ratios were determined in the solution, root, stem and leaf. The two investigated plants were systematically enriched in light isotopes relative to their solutions (Δ Cd = -0.64‰ to -0.29‰ for R. communis and -0.84‰ to -0.31‰ for S. nigrum). Cd isotopes were markedly fractionated among the plant tissues. For both plant species, an enrichment in light Cd isotopes from solution to root was noted, followed by a slight depletion in light Cd isotopes from root to shoot. Noticeably, the chelation process has caused lighter Cd isotope enrichment in the root of R. communis and S. nigrum. Further, the good fits between â–³ Cd and ln F (or between â–³ Cd and ln F ) indicate that Cd isotopic signatures can be used to study Cd transportation during the metabolic process of plants. This study suggests that knowledge of the Cd isotope ratios could also provide new tool for identifying the Cd-avoiding crop cultivars.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180212
[Lr] Fecha última revisión:180212
[St] Status:Publisher


  5 / 413 MEDLINE  
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[PMID]:29306798
[Au] Autor:Gu XY; Shen XF; Wang L; Wu ZW; Li F; Chen B; Zhang GL; Wang MK
[Ad] Dirección:School of Pharmacy and Bioengineering, Chengdu University, Chengdu, 610106, China; Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of S
[Ti] Título:Bioactive steroidal alkaloids from the fruits of Solanum nigrum.
[So] Fuente:Phytochemistry;147:125-131, 2018 Mar.
[Is] ISSN:1873-3700
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:The investigation of the fruits of Solanum nigrum led to the isolation of four previously undescribed steroidal alkaloids, named solanine A, 7α-OH khasianine, 7α-OH solamargine and 7α-OH solasonine, together with six known ones. The structures of the isolated compounds were elucidated unambiguously by spectroscopic data analyses and chemical methods. Solanine A represents an unusual steroidal alkaloid with an unprecedented 6/5/6/5/5/6 hexacyclic ring system, and its structure was confirmed by X-ray single crystal diffraction analysis. Compounds 2-4 were rare naturally occurring steroidal alkaloid glycosides bearing a hydroxyl group at C-7 position. Solanine A showed the most potent inhibitory activity against the LPS-induced NO production in murine RAW264.7 macrophages with an IC value of 3.85 ± 0.71 µM and significant cytotoxicity against MGC803, HepG2 and SW480 cancer cell lines with IC values of 6.00 ± 0.52 µM, 9.25 ± 0.49 µM and 6.23 ± 0.26 µM, respectively.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1801
[Cu] Fecha actualización por clase:180206
[Lr] Fecha última revisión:180206
[St] Status:In-Process


  6 / 413 MEDLINE  
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[PMID]:29327646
[Au] Autor:Abreha K; Lankinen Å; Masini L; Hydbom S; Andreasson E
[Ad] Dirección:Department of Plant Protection, Alnarp, Sweden ; kibrom.abreha@slu.se.
[Ti] Título:Late blight resistance screening of major wild Swedish Solanum species: S. dulcamara, S. nigrum and S. physalifolium.
[So] Fuente:Phytopathology;, 2018 Jan 12.
[Is] ISSN:0031-949X
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:To understand the contribution of wild Solanum species to the epidemiology of potato late blight in Sweden, we characterized the resistance of the three putative alternative hosts; Solanum physalifolium, S. nigrum, and S. dulcamara to Phytophthora infestans, the causal agent of late blight. The pathogen sporulated in all ten investigated S. physalifolium genotypes, suggesting susceptibility (S phenotype). Field-grown S. physalifolium was naturally infected but could regrow, though highly infected genotypes were smaller at the end of the season. In 75 S. nigrum genotypes, there were no symptoms (R phenotype) or a lesion restricted to the point of inoculation (RN phenotype), indicating resistance. In 164 S. dulcamara genotypes, most resistance variability was found within sibling groups. In addition to the three resistance phenotypes (R, RN, S), in S. dulcamara a fourth new resistance phenotype (SL) was identified with lesions larger than the point of inoculation but without visible sporulation of the pathogen. Quantitative PCR confirmed P. infestans growth difference in RN, SL, and S phenotypes. Thus, in Sweden S. physalifolium is susceptible and could be a player in epidemiology. A limited role of S. dulcamara leaves in the epidemiology of late blight was suggested, since no major symptoms have been found in the field.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1801
[Cu] Fecha actualización por clase:180112
[Lr] Fecha última revisión:180112
[St] Status:Publisher
[do] DOI:10.1094/PHYTO-10-17-0355-R


  7 / 413 MEDLINE  
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[PMID]:28918276
[Au] Autor:Li H; Li X; Xiang L; Zhao HM; Li YW; Cai QY; Zhu L; Mo CH; Wong MH
[Ad] Dirección:Guangdong Provincial Research Center for Environment Pollution Control and Remediation Materials, Guangzhou Key Laboratory of Environmental Exposure and Health, School of Environment, Jinan University, Guangzhou 510632, PR China.
[Ti] Título:Phytoremediation of soil co-contaminated with Cd and BDE-209 using hyperaccumulator enhanced by AM fungi and surfactant.
[So] Fuente:Sci Total Environ;613-614:447-455, 2018 Feb 01.
[Is] ISSN:1879-1026
[Cp] País de publicación:Netherlands
[La] Idioma:eng
[Ab] Resumen:Pot experiments were conducted to investigate the uptake and translocation of both Cd and decabromodiphenyl ether (BDE-209) in Solanum nigrum, under the treatments of two arbuscular mycorrhizal fungi [AMF, Funneliformis mosseae (FM) and Rhizophagus intraradices (RI)] and surfactant ß-cyclodextrin (ß-CD). Results showed that S. nigrum treated with either FM or ß-CD significantly elevated shoot biomass and Cd concentrations and contents in shoots. The concentrations of BDE-209 in shoots and the dissipation and debromination efficiencies of BDE-209 in soil were significantly enhanced in S. nigrum treated with ß-CD, inoculated with or without AMF. Moreover, significant positive correlations were found between the BDE-209 dissipation efficiency, the BDE-209 concentrations and contents in roots, and the soil enzymatic activities (polyphenol oxidase or dehydrogenase activities) and between the Cd and BDE-209 contents in shoots or roots. Higher concentrations of lower-brominated products and total PBDEs were detected in shoots than in roots suggesting that BDE-209 might be initially absorbed by roots, then translocated to shoots, and then degraded into lower brominated products in shoots. Considering the plant uptake of Cd and BDE-209 and the efficient removal of those chemicals in soils, the combination of S. nigrum and ß-CD inoculated with or without AMF may be viable alternatives for phytoremediation of the co-contaminated soil.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1709
[Cu] Fecha actualización por clase:180103
[Lr] Fecha última revisión:180103
[St] Status:In-Process


  8 / 413 MEDLINE  
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[PMID]:29217922
[Au] Autor:Agoreyo FO; Ohimai BR; Omigie MI
[Ad] Dirección:Department of Physiology, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin city, Nigeria.
[Ti] Título:Effect of Solanum Nigrun on Uterus of Non-gravid Rats.
[So] Fuente:Ethiop J Health Sci;27(3):239-244, 2017 May.
[Is] ISSN:2413-7170
[Cp] País de publicación:Ethiopia
[La] Idioma:eng
[Ab] Resumen:Background: Solanum nigrum is a widely used plant in oriental medicine where it is considered to be antioxidant, anti- inflammatory and diuretic. This study aimed to evaluate the effect of Solanum Nigrum on uterine contractions. Method: Female Wistar Wister albino rats were used for the study. They were housed in a single large cage in an atmospheric controlled environment. Twenty-four hours before every experiment, 0.2 mg/kg of diethylstilbesterol constituted in 1:1 ethanol/water solution, was administered intraperitoneally as a pre-treatment to the rats to induce oestrus. It was done for two weeks during the study period. The phytochemical analysis was carried out to test for the phytochemical constituent of the plant. Result: The result showed that the extract inhibited the release of intracellular calcium ion. The effect of acetylcholine was significantly inhibited by the extract that is at 200mg/ml (p>0.05) and 300 mg/ml (p<0.01). The highest mean inhibitory effect of the extract observed on acetylcholine induced contractions was 90.54 ± 1.15. The oxytocin induced contraction was significantly inhibited by the extract at 200 mg/ml (p<0.05) and at 300 mg/ml (p<0.001) doses respectively. The highest mean inhibitory effect of the extract observed on Oxytocin induced contractions was 41.10±1.02 and was significantly stronger compared with acetylcholine induced contractions. Conclusion: The aqueous extract of Solanum nigrun inhibited the activity of oxytocin on the uterus, and it may possess relaxant activity.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1712
[Cu] Fecha actualización por clase:171220
[Lr] Fecha última revisión:171220
[St] Status:In-Process


  9 / 413 MEDLINE  
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[PMID]:29084682
[Au] Autor:Fatima I; Hussain T; Rafay M; Akram M; Bano S; Shabbir S
[Ad] Dirección:Department of Life Sciences, Islamia University Bahawalpur, Pakistan.
[Ti] Título:Evaluation of antioxidant activity of leaves and fruits extracts of five medicinal plants.
[So] Fuente:Pak J Pharm Sci;30(5):1625-1628, 2017 Sep.
[Is] ISSN:1011-601X
[Cp] País de publicación:Pakistan
[La] Idioma:eng
[Ab] Resumen:Antioxidants acts as a defense mechanism that protects against oxidative damage caused by free radicals produced in the body. Medicinal plants are preferably used for various diseases in many countries. The studies were conducted to determine the antioxidant capacity of the ethanolic leaves and fruits extracts of Physalis minima, Withania somnifera, Datura inoxia, Solanum nigrum and Kigelia africana by 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay. Quercetin was used as a standard antioxidant which shows 93.66% inhibition. Among the five selected plant species, the percentage of antioxidant activity of leaves extracts was found in order: P. minima > W. somnifera > S. nigrum > K. africana > D. inoxia and fruits extracts was in order: W. somnifera ≥ D. inoxia > P. minima > K. africana > S. nigrum respectively.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1711
[Cu] Fecha actualización por clase:171031
[Lr] Fecha última revisión:171031
[St] Status:In-Data-Review


  10 / 413 MEDLINE  
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[PMID]:29064630
[Au] Autor:Cen Y; Xiao A; Chen X; Liu L
[Ad] Dirección:College of Chemistry and Chemical Engineering, Central South University, Changsha, China.
[Ti] Título:Screening and separation of α-amylase inhibitors from Solanum nigrum with amylase-functionalized magnetic graphene oxide combined with high-speed counter-current chromatography.
[So] Fuente:J Sep Sci;, 2017 Oct 24.
[Is] ISSN:1615-9314
[Cp] País de publicación:Germany
[La] Idioma:eng
[Ab] Resumen:A screening method using α-amylase-functionalized magnetic graphene oxide combined with high-speed counter-current chromatography was proposed and utilized to screen and separate α-amylase inhibitors from extract of Solanum nigrum. The α-amylase-functionalized magnetic graphene oxide was characterized and found to demonstrate satisfactory structure, magnetic response (24.5 emu/g), and reusability (retained 90% of initial activity after five cycles). The conditions for the screening with α-amylase functionalized magnetic graphene oxide were optimized and set at pH 7.0 and 25°C. As a result, two potent flavonoid compounds, apigenin-7-O-glucuronide (1) and astragalin (2), were separated and collected through high-speed counter-current chromatography and subjected to high-performance liquid chromatography analysis with purity higher than 90% (according to HPLC data), which were identified as α-amylase inhibitors. These results suggested that utilization of α-amylase functionalized magnetic graphene oxide in the rapid screening and isolation bioactive compounds from complex natural products is a feasible and environmentally friendly method.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1710
[Cu] Fecha actualización por clase:171120
[Lr] Fecha última revisión:171120
[St] Status:Publisher
[do] DOI:10.1002/jssc.201700333



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