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  1 / 3850 MEDLINE  
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[PMID]:29386359
[Au] Autor:Platt DJ; Smith AM; Arora N; Diamond MS; Coyne CB; Miner JJ
[Ad] Dirección:Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
[Ti] Título:Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice.
[So] Fuente:Sci Transl Med;10(426), 2018 Jan 31.
[Is] ISSN:1946-6242
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Although Zika virus (ZIKV) infection in pregnant women can cause placental damage, intrauterine growth restriction, microcephaly, and fetal demise, these disease manifestations only became apparent in the context of a large epidemic in the Americas. We hypothesized that ZIKV is not unique among arboviruses in its ability to cause congenital infection. To evaluate this, we tested the capacity of four emerging arboviruses [West Nile virus (WNV), Powassan virus (POWV), chikungunya virus (CHIKV), and Mayaro virus (MAYV)] from related (flavivirus) and unrelated (alphavirus) genera to infect the placenta and fetus in immunocompetent, wild-type mice. Although all four viruses caused placental infection, only infection with the neurotropic flaviviruses (WNV and POWV) resulted in fetal demise. WNV and POWV also replicated efficiently in second-trimester human maternal (decidua) and fetal (chorionic villi and fetal membrane) explants, whereas CHIKV and MAYV replicated less efficiently. In mice, RNA in situ hybridization and histopathological analysis revealed that WNV infected the placenta and fetal central nervous system, causing injury to the developing brain. In comparison, CHIKV and MAYV did not cause substantive placental or fetal damage despite evidence of vertical transmission. On the basis of the susceptibility of human maternal and fetal tissue explants and pathogenesis experiments in immunocompetent mice, other emerging neurotropic flaviviruses may share with ZIKV the capacity for transplacental transmission, as well as subsequent infection and injury to the developing fetus.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180311
[Lr] Fecha última revisión:180311
[St] Status:In-Data-Review


  2 / 3850 MEDLINE  
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[PMID]:29505830
[Au] Autor:Fujita DM; Nali LHDS; Salvador FS; Luna EJA
[Ad] Dirección:Instituto de Medicina Tropical de São Paulo, Laboratório de Protozoologia, USP, São Paulo, Brazil. Electronic address: dmfujita@usp.br.
[Ti] Título:Additional travel recommendations for babies and pregnant women after the recent Zika and Chikungunya outbreaks.
[So] Fuente:Travel Med Infect Dis;, 2018 Mar 02.
[Is] ISSN:1873-0442
[Cp] País de publicación:Netherlands
[La] Idioma:eng
[Pt] Tipo de publicación:LETTER
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[St] Status:Publisher


  3 / 3850 MEDLINE  
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[PMID]:29410416
[Au] Autor:Auerswald H; Boussioux C; In S; Mao S; Ong S; Huy R; Leang R; Chan M; Duong V; Ly S; Tarantola A; Dussart P
[Ad] Dirección:Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, PO Box 983, Phnom Penh, Cambodia.
[Ti] Título:Broad and long-lasting immune protection against various Chikungunya genotypes demonstrated by participants in a cross-sectional study in a Cambodian rural community.
[So] Fuente:Emerg Microbes Infect;7(1):13, 2018 Feb 07.
[Is] ISSN:2222-1751
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Chikungunya virus (CHIKV) is an alphavirus circulating worldwide. Its presence in Asia has been reported since the 1950s, constituting the Asian genotype. Since 2005, strains from the Eastern, Central, and Southern African (ECSA) genotype have caused several outbreaks across Asia. Viruses from the ECSA genotype were also detected in Cambodia in late 2011 and led to an outbreak in a rural community in 2012. A former investigation from 2012 found a higher risk of infection in people younger than 40 years, suggesting a pre-existing herd immunity in the older Cambodian population due to infection with an Asian genotype. In 2016, we collected serum from equivalent numbers of individuals born before 1975 and born after 1980 that were also part of the 2012 study. We analyzed the 154 serum samples from 2016 for neutralization against the Cambodian ECSA isolate and three strains belonging to the Asian genotype. This experiment revealed that 22.5% (18/80) of the younger study participants had no CHIKV antibodies, whereas 5.4% (4/74) of the older population remained naive. Study participants infected during the ECSA outbreak had twofold neutralizing titers against the ECSA and the most ancient Asian genotype virus (Thailand 1958) compared to the other two Asian genotype viruses. The neutralization data also support the older population's exposure to an Asian genotype virus during the 1960s. The observed cross-reactivity confirms that the investigated CHIKV strains belong to a single serotype despite the emergence of novel ECSA genotype viruses and supports the importance of the development of a Chikungunya vaccine.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[St] Status:In-Process
[do] DOI:10.1038/s41426-017-0010-0


  4 / 3850 MEDLINE  
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[PMID]:29517478
[Au] Autor:Sukkaew A; Thanagith M; Thongsakulprasert T; Mutso M; Mahalingam S; Smith DR; Ubol S
[Ad] Dirección:1​Department of Microbiology, Faculty of Science, Mahidol University, Rama 6 Rd., Ratchatewi, Bangkok 10400, Thailand.
[Ti] Título:Heterogeneity of clinical isolates of chikungunya virus and its impact on the responses of primary human fibroblast-like synoviocytes.
[So] Fuente:J Gen Virol;, 2018 Mar 08.
[Is] ISSN:1465-2099
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Low-passage clinical isolates of chikungunya virus (CHIKV) were found to be a mixture of large- and small-plaque viruses, with small-plaque viruses being the predominant species. To investigate the contribution of plaque variants to the pathology of the joint, primary human fibroblast-like synoviocytes (HFLS) were used. Large- and small-plaque viruses were purified from two clinical isolates, CHIKV-031C and CHIKV-033C, and were designated CHIKV-031L and CHIKV-031S and CHIKV-033L and CHIKV-033S, respectively. The replication efficiencies of these viruses in HFLSs were compared and it was found that CHIKV-031S and CHIKV-033S replicated with the highest efficiency, while the parental clinical isolates had the lowest efficiency. Interestingly, the cytopathic effects (CPE) induced by these viruses correlated with neither the efficiency of replication nor the plaque size. The small-plaque viruses and the clinical isolates induced cell death rapidly, while large-plaque viruses induced slow CPE in which only 50 % of the cells in infected cultures were rounded up and detached on day 5 of infection. The production of proinflammatory cytokines and chemokines from infected HFLSs was evaluated. The results showed that the large-plaque viruses and the clinical isolates, but not small-plaque variants, were potent inducers of IL-6, IL-8 and MCP-1, and were able to migrate monocytes/macrophages efficiently. Sequencing data revealed a number of differences in amino acid sequences between the small- and large-plaque viruses. The results suggest that it is common for clinical isolates of CHIKV to be heterogeneous, while the variants may have distinct roles in the pathology of the joint.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180308
[Lr] Fecha última revisión:180308
[St] Status:Publisher
[do] DOI:10.1099/jgv.0.001039


  5 / 3850 MEDLINE  
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[PMID]:29513923
[Au] Autor:Chang AY; Encinales L; Bethony JM; Simon GL
[Ad] Dirección:The George Washington University, Washington, DC.
[Ti] Título:Reply to Comments on the "Frequency of Chronic Joint Pain following Chikungunya Infection: A Colombian Cohort Study", the Brazilian Experience.
[So] Fuente:Arthritis Rheumatol;, 2018 Mar 07.
[Is] ISSN:2326-5205
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Supported by the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR-001877). We would like to thank Mogami et. al., for sharing their experience with chikungunya virus in the Brazilian context, especially highlighting the possible utility of ultrasound during the sub-acute phase to identify severe or evolving cases of arthritis. Indeed, Doppler ultrasound may be an effective approach to identify patients that might benefit from treatment with disease modifying agents such as methotrexate during the sub-acute phase. However, further peer-reviewed research is needed to define the role of ultrasound in the selection of patients for aggressive treatment. This article is protected by copyright. All rights reserved.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180307
[Lr] Fecha última revisión:180307
[St] Status:Publisher
[do] DOI:10.1002/art.40474


  6 / 3850 MEDLINE  
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[PMID]:29513921
[Au] Autor:Mogami R; De Abreu MM; Sztajnbock F; Koifman ACB; de A Vieira A; Torezani RS; de F B Chagas Y; Vaz JLP
[Ad] Dirección:Department of Radiology, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
[Ti] Título:Comments on the article "Frequency of Chronic Joint Pain following Chikungunya Infection: A Colombian Cohort Study", the Brazilian Experience.
[So] Fuente:Arthritis Rheumatol;, 2018 Mar 07.
[Is] ISSN:2326-5205
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:We read with interest the article Frequency of Chronic Joint Pain following Chikungunya Infection: A Colombian Cohort Study published in the December issue of this journal. We would like to congratulate the authors for their excellent work, a pioneer in the Americas with such a large cohort and accompanied by so much time. We recently performed a study with 50 patients with a confirmed diagnosis of chikungunya fever. The study was performed between 2016-2017 in the city of Rio de Janeiro, Brazil. In this work, ultrasonography was used to study the lesions on the wrists, hands and ankles. This article is protected by copyright. All rights reserved.
[Pt] Tipo de publicación:LETTER
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180307
[Lr] Fecha última revisión:180307
[St] Status:Publisher
[do] DOI:10.1002/art.40477


  7 / 3850 MEDLINE  
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[PMID]:29513844
[Au] Autor:Cavalcanti LPG; D'angelo SM; Lemos DRQ; Barreto FKA; Siqueira AM; Miyajima F
[Ad] Dirección:Programa de Pós-Graduação em Saúde Pública, Universidade Federal do Ceará, Fortaleza, CE, Brasil.
[Ti] Título:Is the recent increment in attributable deaths to type-2 diabetes (T2D) associated with the latest chikungunya outbreak in a major epidemic area in Brazil?
[So] Fuente:Rev Soc Bras Med Trop;51(1):63-65, 2018 Jan-Feb.
[Is] ISSN:1678-9849
[Cp] País de publicación:Brazil
[La] Idioma:eng
[Ab] Resumen:INTRODUCTION: Chikungunya virus (CHIKV) can negatively influence outcomes in patients with pre-existing conditions. We investigated the association between the recent CHIKV outbreak and increased type 2 diabetes (T2D)-attributable deaths. METHODS: Monthly averages of T2D-attributable deaths between 2001 and 2016 were determined and compared to the equivalent data for 2017 and the recent CHIKV outbreak. RESULTS: CHKV outbreak peaked in April 2017 with 4,394.4 cases/100,000 inhabitants, while T2D-attributable deaths in the same period increased by 35.2%. CONCLUSIONS: T2D-attributable deaths significantly increased compared to the previous data, which overlapped with CHIKV incidence. The pathophysiology of this association warrants further investigations.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180307
[Lr] Fecha última revisión:180307
[St] Status:In-Process


  8 / 3850 MEDLINE  
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[PMID]:29513751
[Au] Autor:Zapletal J; Erraguntla M; Adelman ZN; Myles KM; Lawley MA
[Ad] Dirección:Department of Industrial and Systems Engineering, Texas A&M University, College Station, Texas, United States of America.
[Ti] Título:Impacts of diurnal temperature and larval density on aquatic development of Aedes aegypti.
[So] Fuente:PLoS One;13(3):e0194025, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:The increasing range of Aedes aegypti, vector for Zika, dengue, chikungunya, and other viruses, has brought attention to the need to understand the population and transmission dynamics of this mosquito. It is well understood that environmental factors and breeding site characteristics play a role in organismal development and the potential to transmit pathogens. In this study, we observe the impact of larval density in combination with diurnal temperature on the time to pupation, emergence, and mortality of Aedes aegypti. Experiments were conducted at two diurnal temperature ranges based on 10 years of historical temperatures of Houston, Texas (21-32°C and 26.5-37.5°C). Experiments at constant temperatures (26.5°C, 32°C) were also conducted for comparison. At each temperature setting, five larval densities were observed (0.2, 1, 2, 4, 5 larvae per mL of water). Data collected shows significant differences in time to first pupation, time of first emergence, maximum rate of pupation, time of maximum rate of pupation, maximum rate of emergence, time of maximum rate of emergence, final average proportion of adult emergence, and average proportion of larval mortality. Further, data indicates a significant interactive effect between temperature fluctuation and larval density on these measures. Thus, wild population estimates should account for temperature fluctuations, larval density, and their interaction in low-volume containers.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180307
[Lr] Fecha última revisión:180307
[St] Status:In-Data-Review
[do] DOI:10.1371/journal.pone.0194025


  9 / 3850 MEDLINE  
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[PMID]:29405105
[Au] Autor:Feldstein LR; Rowhani-Rahbar A; Staples JE; Halloran ME; Ellis EM
[Ad] Dirección:Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington.
[Ti] Título:An Assessment of Household and Individual-Level Mosquito Prevention Methods during the Chikungunya Virus Outbreak in the United States Virgin Islands, 2014-2015.
[So] Fuente:Am J Trop Med Hyg;98(3):845-848, 2018 Mar.
[Is] ISSN:1476-1645
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Recent large-scale chikungunya virus (CHIKV) and Zika virus epidemics in the Americas pose a growing public health threat. Given that mosquito bite prevention and vector control are the main prevention methods available to reduce transmission of these viruses, we assessed adherence to these methods in the United States Virgin Islands (USVI). We interviewed 334 USVI residents between December 2014 and February 2015 to measure differences in mosquito prevention practices by gender, income, presence of CHIKV symptoms, and age. Only 27% (91/334) of participants reported having an air conditioner, and of the 91 with air-conditioners, 18 (20%) reported never using it. Annual household income > $50,000 was associated with owning and using an air conditioner (41%; 95% confidence interval [CI]: 28-53% compared with annual household income ≤ $50,000: 17%; 95% CI: 12-22%). The majority of participants reported the presence of vegetation in their yard or near their home (79%; 265) and a cistern on their property (78%; 259). Only 52 (16%) participants reported wearing mosquito repellent more than once per week. Although the majority (80%; 268) of participants reported having screens on all of their windows and doors, most (82%; 273) of those interviewed still reported seeing mosquitoes in their homes. Given the uniformly low adherence to individual- and household-level mosquito bite prevention measures in the USVI, these findings emphasize the need for improved public health messaging and investment in therapeutic and vaccine research to mitigate vector-borne disease outbreaks.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180308
[Lr] Fecha última revisión:180308
[St] Status:In-Data-Review
[do] DOI:10.4269/ajtmh.17-0799


  10 / 3850 MEDLINE  
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[PMID]:29394382
[Au] Autor:Nakayama E; Tajima S; Kotaki A; Shibasaki KI; Itokawa K; Kato K; Yamashita A; Sekizuka T; Kuroda M; Tomita T; Saijo M; Takasaki T
[Ad] Dirección:Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan.
[Ti] Título:A summary of the imported cases of Chikungunya fever in Japan from 2006 to June 2016.
[So] Fuente:J Travel Med;25(1), 2018 Jan 01.
[Is] ISSN:1708-8305
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Background: Due to the huge 2-way human traffic between Japan and Chikungunya (CHIK) fever-endemic regions, 89 imported cases of CHIK fever were confirmed in Japan from January 2006 to June 2016. Fifty-four of 89 cases were confirmed virologically and serologically at the National Institute of Infectious Diseases, Japan and we present the demographic profiles of the patients and the phylogenetic features of 14 CHIK virus (CHIKV) isolates. Methods: Patients were diagnosed with CHIK fever by a combination of virus isolation, viral RNA amplification, IgM antibody-, IgG antibody-, and/or neutralizing antibody detection. The whole-genome sequences of the CHIKV isolates were determined by next-generation sequencing. Results: Prior to 2014, the source countries of the imported CHIK fever cases were limited to South and Southeast Asian countries. After 2014, when outbreaks occurred in the Pacific and Caribbean Islands and Latin American countries, there was an increase in the number of imported cases from these regions. A phylogenetic analysis of 14 isolates revealed that four isolates recovered from three patients who returned from Sri Lanka, Malaysia and Angola, belonged to the East/Central/South African genotype, while 10 isolates from 10 patients who returned from Indonesia, the Philippines, Tonga, the Commonwealth of Dominica, Colombia and Cuba, belonged to the Asian genotype. Conclusion: Through the phylogenetic analysis of the isolates, we could predict the situations of the CHIK fever epidemics in Indonesia, Angola and Cuba. Although Japan has not yet experienced an autochthonous outbreak of CHIK fever, the possibility of the future introduction of CHIKV through an imported case and subsequent local transmission should be considered, especially during the mosquito-active season. The monitoring and reporting of imported cases will be useful to understand the situation of the global epidemic, to increase awareness of and facilitate the diagnosis of CHIK fever, and to identify a future CHIK fever outbreak in Japan.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180308
[Lr] Fecha última revisión:180308
[St] Status:In-Data-Review
[do] DOI:10.1093/jtm/tax072



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