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Registro de Ensayos Clínicos
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[PMID]:29414988
[Au] Autor:Morgan SJ; McDonald CL; Halsne EG; Cheever SM; Salem R; Kramer PA; Hafner BJ
[Ad] Dirección:Department of Rehabilitation Medicine, University of Washington, Seattle, WA, United States of America.
[Ti] Título:Laboratory- and community-based health outcomes in people with transtibial amputation using crossover and energy-storing prosthetic feet: A randomized crossover trial.
[So] Fuente:PLoS One;13(2):e0189652, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Contemporary prosthetic feet are generally optimized for either daily or high-level activities. Prosthesis users, therefore, often require multiple prostheses to participate in activities that span a range of mobility. Crossover feet (XF) are designed to increase the range of activities that can be performed with a single prosthesis. However, little evidence exists to guide clinical prescription of XF relative to traditional energy storing feet (ESF). The objective of this study was to assess the effects of XF and ESF on health outcomes in people with transtibial amputation. A randomized crossover study was conducted to assess changes in laboratory-based (endurance, perceived exertion, walking performance) and community-based (step activity and self-reported mobility, fatigue, balance confidence, activity restrictions, and satisfaction) outcomes. Twenty-seven participants were fit with XF and ESF prostheses with standardized sockets, interfaces, and suspensions. Participants were not blinded to the intervention, and wore each prosthesis for one month while their steps were counted with an activity monitor. After each accommodation period, participants returned for data collection. Endurance and perceived exertion were measured with the Six-Minute Walk Test and Borg-CR100, respectively. Walking performance was measured using an electronic walkway. Self-reported mobility, fatigue, balance confidence, activity restrictions, and satisfaction were measured with survey instruments. Participants also reported foot preferences upon conclusion of the study. Differences between feet were assessed with a crossover analysis. While using XF, users experienced improvements in most community-based outcomes, including mobility (p = .001), fatigue (p = .001), balance confidence (p = .005), activity restrictions (p = .002), and functional satisfaction (p < .001). Participants also exhibited longer sound side steps in XF compared to ESF (p < .001). Most participants (89%) reported an overall preference for XF; others (11%) reported no preference. Results indicate that XF may be a promising alternative to ESF for people with transtibial amputation who engage in a range of mobility activities. TRIAL REGISTRATION: ClinicalTrials.gov NCT02440711.
[Mh] Términos MeSH primario: Amputación
Miembros Artificiales
Pie
Prótesis e Implantes
Tibia/cirugía
[Mh] Términos MeSH secundario: Estudios Cruzados
Seres Humanos
Resultado del Tratamiento
[Pt] Tipo de publicación:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180208
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189652


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[PMID]:29429180
[Au] Autor:Hu J; Chen ZC; Zhang YZ; Han P; Ma WJ; Zhang Q; Xu M
[Ad] Dirección:Department of Otorhinolaryngology Head and Neck Surgery, Second Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an 710004, China.
[Ti] Título:[The experimental study on endoplasmic reticulum stress-participated outer hair cell apoptosis in cadherin 23 gene mutant mice].
[So] Fuente:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;53(2):110-117, 2018 Feb 07.
[Is] ISSN:1673-0860
[Cp] País de publicación:China
[La] Idioma:chi
[Ab] Resumen:To test the mechanism and upstream pathway of outer hair cell apoptosis in Cadherin 23 (Cdh23) gene mutant mice. The mutant 23 ( ) 57 /6 ( 6) . 70 . - ( ) . ( ) ( ) . - - ( ) / ( ) . . . 23 . The ABR thresholds in mice were significantly higher than those in B6 mice at the age of 1 and 3 months (both <0.05). The surface preparation with TUNEL staining confirmed OHC apoptosis in mouse cochleae which showed a higher TUNEL positive cell ratio than B6 mouse( =11.291, <0.01). The ER stress marker and mRNA were upregulated in the mouse inner ear, when compared with those in the B6 mouse(both <0.05). The BiP protein extracted from the mouse cochleae was significantly higher than that of B6 mouse measured by Western blot ( =3.66, =0.02). Immunostaining showed that BiP and CHOP were highly detected in the OHC in mouse cochleae, and was mainly detected in the perinuclear region of OHC. However, a bare BiP and CHOP signal were shown in B6 mouse cochleae. The CDH23 protein was specifically localized at the top of the OHC in B6 mice, indicating the localization of the tip links in hair bundle stereocilia. On the contrary, the CDH23 protein was found to be localized from the top to the nuclei of the OHC in mice. Portions of the CDH23 proteins failed to reach the top of the hair bundles and remained in the OHC cytoplasm. As the downstream response of the Cdh23 gene mutation, portions of the mutant CDH23 protein was accumulated in ER lumen resulting in the increase of ER loading and ultimately triggered ER stress and hair cell apoptosis in mouse cochleae.
[Mh] Términos MeSH primario: Apoptosis/genética
Cadherinas/genética
Estrés del Retículo Endoplásmico/genética
Células Ciliadas Auditivas Externas/patología
[Mh] Términos MeSH secundario: Animales
Western Blotting
Cóclea/patología
Estrés del Retículo Endoplásmico/fisiología
Potenciales Evocados Auditivos del Tronco Encefálico
Células Ciliadas Vestibulares
Etiquetado Corte-Fin in Situ
Linfocinas/metabolismo
Ratones
Ratones Consanguíneos C57BL
Mutación
ARN Mensajero/metabolismo
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
Factor de Transcripción CHOP/genética
Factor de Transcripción CHOP/metabolismo
Regulación hacia Arriba
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Cadherins); 0 (Cdh23 protein, mouse); 0 (Lymphokines); 0 (RNA, Messenger); 0 (immunoglobulin-binding factors); 147336-12-7 (Transcription Factor CHOP)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180307
[Lr] Fecha última revisión:180307
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180213
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2018.02.006


  3 / 78644 MEDLINE  
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[PMID]:29231023
[Au] Autor:Zhang WL; Du YL
[Ad] Dirección:Criminal Technology Branch, Agricultural Areas Public Security Bureau, Harbin 150038, China.
[Ti] Título:[Analysis on the Injury Mechanism and Characteristics of Ox Horn].
[So] Fuente:Fa Yi Xue Za Zhi;33(2):162-164, 2017 Apr.
[Is] ISSN:1004-5619
[Cp] País de publicación:China
[La] Idioma:chi
[Ab] Resumen:OBJECTIVES: To study the morphological characteristics of the injury caused by ox horn on human body and its injury mechanism, and to discuss the rules and characteristics of injury by ox horn and provide forensic evidences for identification of such cases. METHODS: The comparative analysis of position and morphological characteristics were performed by summarizing the data of 100 victims gored by ox accepted by Heilongjiang agricultural areas public security bureau during 2004-2014. RESULTS: The specific injuries only could be found at the contact positions such as thorax and abdomen, lower back and limbs of the victims gored by ox horn. Most of the skin wounds had the characteristics of sharp injuries, the bar-type injury by club which called "rail way bruise" was an obvious characteristic appeared on the soft tissue. CONCLUSIONS: Ox horn can cause non-specific injuries on thorax and abdomen, lower back and limbs of human body, which are similar with the characteristics of sharp injury and injury by club. Careful analyzation and identification should be performed on such injury in daily work.
[Mh] Términos MeSH primario: Traumatismos Abdominales/etiología
Tórax
Heridas y Lesiones/etiología
Heridas Penetrantes
[Mh] Términos MeSH secundario: Animales
Bovinos
Femenino
Seres Humanos
Extremidad Inferior
[Pt] Tipo de publicación:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180308
[Lr] Fecha última revisión:180308
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:171213
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2017.02.011


  4 / 78644 MEDLINE  
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[PMID]:29231007
[Au] Autor:Du YL; Zhang WL
[Ad] Dirección:Nine-three Reclamation Public Security Bureau, Nenjiang 161441, China.
[Ti] Título:[Automobile Traffic Accident Death Case Analysis of Characteristics of Driver Injury].
[So] Fuente:Fa Yi Xue Za Zhi;33(1):36-37, 2017 Feb.
[Is] ISSN:1004-5619
[Cp] País de publicación:China
[La] Idioma:chi
[Ab] Resumen:OBJECTIVES: To distinguish the injury characteristic changes on the drivers between the injuries of drivers and passengers in traffic accidents, and to provide scientific evidence for confirming the identity of driver in traffic accidents. METHODS: Data of 126 automobile traffic accident death cases in the reclamation areas of Heilongjiang province from 2006-2014 were retrospectively studied. The injury characteristics on the drivers of automobile traffic accident death cases were analyzed and the forensic identification problem in the injuries of drivers and passengers were discussed. RESULTS: Injuries were frequently observed on driver's neck, chest and abdomen. The characteristic injuries caused by auto parts were also found, which appeared at the places of passenger's head, face and limbs contacted with automobile. Such characteristic injuries were not found at other places. CONCLUSIONS: The location and type of injury are associated with the identity of the deceased.
[Mh] Términos MeSH primario: Accidentes de Tránsito/mortalidad
Conducción de Automóvil/estadística & datos numéricos
[Mh] Términos MeSH secundario: Accidentes de Tránsito/estadística & datos numéricos
Automóviles
China/epidemiología
Muerte
Extremidades/lesiones
Femenino
Cabeza
Seres Humanos
Estudios Retrospectivos
Tórax
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180308
[Lr] Fecha última revisión:180308
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:171213
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2017.01.009


  5 / 78644 MEDLINE  
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[PMID]:29482510
[Au] Autor:Zhao MH; Hu J; Li S; Wu Q; Lu P
[Ad] Dirección:Department of Ophthalmology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
[Ti] Título:P66Shc expression in diabetic rat retina.
[So] Fuente:BMC Ophthalmol;18(1):58, 2018 Feb 27.
[Is] ISSN:1471-2415
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:BACKGROUND: P66Shc is partially localised within the mitochondrial fraction. It is primarily related to the generation of mitochondrial reactive oxygen species and apoptosis. Based on previous studies, we hypothesize that in the retina, p66Shc may exist and affect the development of diabetic retinopathy. The purpose of this study was to investigate p66Shc expression in retinal in streptozotocin-induced diabetic (SD) rats, which may provide a pathway to study the pathogenesis of diabetic retinopathy. METHODS: Reverse transcription-polymerase chain reaction (RT-PCR) and western blot were used to detect retinal p66Shc mRNA and protein expression in SD rats, respectively. Immunohistochemical staining was applied to detect the location of rat retinal p66Shc expression. TUNEL assay was applied to detect the number of apoptotic cells. RESULTS: P66Shc expression was found in the retina of normal and diabetic rats, and the level of mRNA and protein expression increased with the progression of diabetes mellitus (DM). P66Shc expression was mainly located in the retinal ganglion cell layer and inner nuclear layer. Compared with the normal group, retinal cell tissue apoptosis rate in the D12w group was significantly increased. CONCLUSION: Rat retinal p66Shc expression was mainly in the ganglion cell layer and inner nuclear layer. As the degree of DM progressed, p66Shc expression gradually increased, and the number of apoptotic cells also increased.
[Mh] Términos MeSH primario: Diabetes Mellitus Experimental/metabolismo
Retinopatía Diabética/metabolismo
Retina/metabolismo
Proteína Transformadora 1 que Contiene Dominios de Homología 2 de Src/metabolismo
[Mh] Términos MeSH secundario: Animales
Western Blotting
Inmunohistoquímica
Etiquetado Corte-Fin in Situ
Masculino
Ratas
Ratas Sprague-Dawley
Reacción en Cadena en Tiempo Real de la Polimerasa
Células Ganglionares de la Retina/metabolismo
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Shc1 protein, rat); 0 (Src Homology 2 Domain-Containing, Transforming Protein 1)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180306
[Lr] Fecha última revisión:180306
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180228
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0724-3


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[PMID]:29429158
[Au] Autor:Sun M; Liu JG; Weng QY; Yu L; Wang J
[Ad] Dirección:Department of Pathology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
[Ti] Título:[Pleomorphic and dedifferentiated leiomyosarcoma: a clinicopathologic analysis].
[So] Fuente:Zhonghua Bing Li Xue Za Zhi;47(2):87-93, 2018 Feb 08.
[Is] ISSN:0529-5807
[Cp] País de publicación:China
[La] Idioma:chi
[Ab] Resumen:To investigate the clinicopathologic features, differential diagnosis and biological behavior of pleomorphic leiomyosarcoma (PLMS) and dedifferentiated leiomyosarcoma (DLMS). Forty-nine cases were collected from November 2007 to December 2016, including eight that diagnosed at Fudan University Shanghai Cancer Center, and 41 consultation cases. The clinical findings and pathologic features were reviewed. Immunophenotype was obtained in 33 cases and follow-up information was available in 38 cases. There were 22 males and 27 females with ages ranging from 24 to 83 years (mean 52.5 years). Fifteen cases occurred in extremities, 14 in deep body cavity, 11 in the trunk, 4 in the head and neck, 2 in the bladder, and 1 each in the inguinal region, perineum and femoral vein, respectively. Tumor sizes ranged from 3 to 30 cm (mean 9.1 cm). The tumors were composed of at least small foci of typical leiomyosarcoma (LMS) and areas of high-grade pleomorphic/undifferentiated sarcoma. The typical LMS component showed the characteristic morphology of smooth muscle differentiation and was low to intermediate grade in most cases. Pleomorphic areas were mainly composed of atypical spindle and polygonal cells admixed with variable large, bizarre atypical cells and multinuclear giant cells, mostly mimicking undifferentiated pleomorphic sarcoma. The pleomorphic and leiomyosarcomatous areas were usually intermixed, but the demarcation may be distinct or gradual in some cases. The classical LMS component was positive for at least one myogenic marker: α-SMA in 97.0%(32/33), desmin in 72.7%(24/33), H-caldesmon in 90.9% (20/22), MSA in 14/16, and calponin in 15/15 of cases. The pleomorphic sarcoma component was reactive for at least one myogenic marker in 87.9% (29/33) of cases, usually showing focal and less intense immunoreactivity than classical LMS component: α-SMA was positive in 81.8%(27/33), desmin in 48.5%(16/33), H-caldesmon in 72.7% (16/22), MSA in 12/16, and calponin in 11/15 of cases. Based on staining for muscle markers in the pleomorphic component, 29 cases were designated as PLMS, 4 as DLMS. Ki-67 index ranged from 15% to 70% (mean 40%). Follow-up data was available in 38 cases (77.6%), of which 11 patients (28.9%) died of disease, 12 patients were alive with unresectable or recurrent disease, 14 patients were alive with no evidence of disease and another one died of unrelated cause. The median disease-free and overall survival was 6 and 10 months respectively. Twelve patients exhibited local recurrence and 11 developed metastases. The median interval to progression was 8 months. The identification of areas of typical LMS is crucial for accurate diagnosis of PLMS and DLMS. Both PLMS and DLMS show more aggressive behavior and poorer prognosis than ordinary LMS.
[Mh] Términos MeSH primario: Leiomiosarcoma/patología
Neoplasias Cutáneas/patología
[Mh] Términos MeSH secundario: Actinas/análisis
Adulto
Anciano
Anciano de 80 o más Años
Biomarcadores de Tumor/análisis
Proteínas de Unión al Calcio/análisis
Proteínas de Unión a Calmodulina/análisis
Diferenciación Celular
China
Desmina/análisis
Diagnóstico Diferencial
Extremidades
Femenino
Histiocitoma Fibroso Maligno/química
Histiocitoma Fibroso Maligno/patología
Seres Humanos
Inmunohistoquímica
Inmunofenotipificación
Leiomiosarcoma/química
Masculino
Proteínas de Microfilamentos/análisis
Mediana Edad
Recurrencia Local de Neoplasia
Neoplasias Cutáneas/química
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (ACTA2 protein, human); 0 (Actins); 0 (Biomarkers, Tumor); 0 (Calcium-Binding Proteins); 0 (Calmodulin-Binding Proteins); 0 (Desmin); 0 (Microfilament Proteins); 0 (calponin)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180306
[Lr] Fecha última revisión:180306
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180213
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2018.02.002


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[PMID]:28470463
[Au] Autor:Hoffmeister T; Schwarze F; Aschoff HH
[Ad] Dirección:Sana Kliniken Lübeck GmbH, Kronsforder Allee 71/73, 23560, Lübeck, Deutschland.
[Ti] Título:[The endo-exo prosthesis treatment concept : Improvement in quality of life after limb amputation].
[Ti] Título:Das Endo-Exo-Prothesen-Versorgungskonzept : Verbesserung der Lebensqualität nach Extremitätenamputation..
[So] Fuente:Unfallchirurg;120(5):371-377, 2017 May.
[Is] ISSN:1433-044X
[Cp] País de publicación:Germany
[La] Idioma:ger
[Ab] Resumen:Osseointegrated, percutaneous implants as the force bearer for exoprosthetics after limb amputation have been used in individual cases for clinical rehabilitation of amputees during the past years. Most experience in this field in Germany has been accumulated at the Sana Klinik in Lübeck with the so-called endo-exo prosthesis (EEP) system. The two-step implantation procedure can now be considered as reliable. Following a well-documented learning curve initial soft tissue problems concerning the cutaneous stoma can now be regarded as exceptions. The retrospective examination of the results concerning by now more than 100 patients provided with an endo-exo femoral prosthesis (EEFP) showed a very satisfying outcome concerning objective as well as subjective values, such as duration of daily use and wearing comfort of the exoprosthesis. Regaining the ability of osseoperception due to the intraosseous fixation is described by the patients as a great advantage. The step from a socket prosthesis to an EEP is felt to be a big increase in quality of life by nearly all patients included into the follow-up. Nearly all of the patients questioned would choose an endo-exo prosthesis again. Meanwhile, the success of the EEP resulted in the broadening of indications from above-knee amputations to transtibial as well as transhumeral amputations. The results are likewise encouraging. The use of EEP for the upper limbs leads to substantial improvement in the range of motion of the shoulder joint with the intramedullary anchored percutaneous implant. Furthermore, new pathbreaking possibilities in the fixation of myoelectrically controlled arm prostheses may arise from the EEP technique.
[Mh] Términos MeSH primario: Muñones de Amputación/cirugía
Amputación/rehabilitación
Artroplastia de Reemplazo de Cadera/instrumentación
Dispositivo Exoesqueleto
Prótesis de Cadera
Pierna/cirugía
Calidad de Vida/psicología
[Mh] Términos MeSH secundario: Amputación/psicología
Artroplastia de Reemplazo de Cadera/métodos
Artroplastia de Reemplazo de Cadera/psicología
Miembros Artificiales
Terapia Combinada/instrumentación
Terapia Combinada/métodos
Terapia Combinada/psicología
Seres Humanos
Oseointegración
Diseño de Prótesis
Resultado del Tratamiento
[Pt] Tipo de publicación:JOURNAL ARTICLE; REVIEW
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180306
[Lr] Fecha última revisión:180306
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170505
[St] Status:MEDLINE
[do] DOI:10.1007/s00113-017-0350-1


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[PMID]:28470462
[Au] Autor:Grundei H; Timmermann A
[Ad] Dirección:Fa. Eska Orthopaedic Handels GmbH, Osterweide 2c, 23562, Lübeck, Deutschland. info@eskaorthopaedic.de.
[Ti] Título:[Connecting adapter for coupling exoprostheses to endoshafts : Demands on orthopedic technicians with respect to planning and application].
[Ti] Título:Anschlussadapter zur Ankopplung der Exoprothese an den Endostiel : Anforderungen an den Orthopädietechniker hinsichtlich Planung und Anwendung..
[So] Fuente:Unfallchirurg;120(5):378-384, 2017 May.
[Is] ISSN:1433-044X
[Cp] País de publicación:Germany
[La] Idioma:ger
[Ab] Resumen:INTRODUCTION: Transcutaneous, bone anchored prostheses have proved to be an alternative for amputees. In addition to the safe osseointegration of the implant, the correct prosthetic alignment is also important. Therefore, the interaction between prosthesis components and the prosthesis wearer is significant and the role of the certified prosthetist should not be underestimated. AIM: The aim of treatment is the best possible compensation of disability after limb loss with increase of physical abilities and comfort of the prosthesis wearer by means of bone anchored prosthesis. METHOD: Endoprosthesis inserted by the surgeon carrying out both surgery with the implant and a double-cone and 6 weeks later the exoprosthesis is fitted by the certified prosthetist orthotist (CPO). Mounting the external adaptors, assembly of the prosthesis. RESULTS: The long-term results with cementless implants and more than 35 years experience are presented. Clinical experience with the endo-exo prosthesis since 1999. A total of 135 patients treated after transfemoral amputation, 8 of them bilateral, 8 out of 135 were transtibial amputees and 1 of them bilateral. A total of 85% were amputated as a consequence of trauma and 12 out of 135 had a full range of motion at the beginning of the prosthetic work following osseointegration. In other cases, a hip flexion contracture between 3 and 12 ° had to be considered by corresponding posterior displacement adaptors. CONCLUSION: Bone anchored prostheses influence the skeleton and joints in a more direct way. This fact requires specific prosthetic measures concerning the connection between the endo-implant and the exoprosthesis. Therefore, specially matched adaptors and the prosthetic alignment are the focus of interest. Prostheses connected to an osseointegrated implant have many biomechanical advantages compared to socket-guided prostheses. Because the quality of rehabilitation is clearly affected by the prosthetic alignment, it has to be carried out extremely carefully and precisely if the prosthesis is connected to an osseointegrated implant. According to the survey, none of the prosthesis wearers wanted to return to a socket-guided prosthesis.
[Mh] Términos MeSH primario: Muñones de Amputación/cirugía
Amputación/rehabilitación
Artroplastia de Reemplazo/instrumentación
Miembros Artificiales
Dispositivo Exoesqueleto
Prótesis Articulares
Pierna/cirugía
[Mh] Términos MeSH secundario: Artroplastia de Reemplazo/métodos
Terapia Combinada/instrumentación
Terapia Combinada/métodos
Seres Humanos
Oseointegración
Diseño de Prótesis
Estudios Retrospectivos
Resultado del Tratamiento
[Pt] Tipo de publicación:JOURNAL ARTICLE; REVIEW
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180306
[Lr] Fecha última revisión:180306
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170505
[St] Status:MEDLINE
[do] DOI:10.1007/s00113-017-0351-0


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[PMID]:29480881
[Au] Autor:Wu YH; Liu KT; Yeh IJ; Chang CW
[Ad] Dirección:Department of Emergency Medicine, Kaohsiung Medical University Hospital.
[Ti] Título:Cheiro-Oral syndrome caused by thalamus hemorrhage: A case report.
[So] Fuente:Medicine (Baltimore);97(2):e9652, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:RATIONALE: Cheiro-Oral syndrome (COS) is a pure sensory deficit confined to the perioral area and ipsilateral distal fingers or hand. Owing to relatively minor clinical findings and various presentations in different cases, the insidious and severe illness it implies may be overlooked at acute settings. PATIENT CONCERNS: A 70-year-old man with history of hypertension and type II diabetes mellitus under regular medication control came to our emergency department with chief complaint of sudden onset of right perioral region and right upper limb numbness. General physical and neurological examinations were normal except for subtle hypoesthesia to light touch, and pinprick in the right corner of mouth and right forearm to distal fingers. DIAGNOSES: Routine blood analysis was all in normal range including white blood cell count, hemocrit platelet, renal and liver function, and electrolytes such as sodium and potassium. Noncontrast brain computed tomography showed abnormal high-attenuation collection in the left thalamus. INTERVENTION: Follow-up computed tomography showed absorption of the hemorrhage after strict control of his blood pressure. OUTCOMES: The patient was discharged 7 days later from our hospital with stable condition. LESSONS: We demonstrated type I COS associated with thalamic hemorrhage to highlight the neurological implication of COS. It is crucial for emergency clinicians to recognize the symptoms and promptly order a neuroimaging study to exclude large infarction/hemorrhage, which would deeply affect the disposition and following treatment of the patient.
[Mh] Términos MeSH primario: Hemorragia Cerebral/complicaciones
Trastornos de la Sensación/etiología
[Mh] Términos MeSH secundario: Anciano
Hemorragia Cerebral/diagnóstico por imagen
Hemorragia Cerebral/terapia
Diagnóstico Diferencial
Seres Humanos
Masculino
Boca
Trastornos de la Sensación/diagnóstico por imagen
Trastornos de la Sensación/terapia
Síndrome
Tálamo/diagnóstico por imagen
Tomografía Computarizada por Rayos X
Extremidad Superior
[Pt] Tipo de publicación:CASE REPORTS; JOURNAL ARTICLE
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180305
[Lr] Fecha última revisión:180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009652


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[PMID]:29480853
[Au] Autor:Zhou F; Song W; Wang Z; Yin L; Yang S; Yang F; Song Z; Song Y; Zhang H; Qiao F; Zhang Z
[Ad] Dirección:Medical Examination Center of Qilu Hospital of Shandong University, Jinan.
[Ti] Título:Effects of remote ischemic preconditioning on contrast induced nephropathy after percutaneous coronary intervention in patients with acute coronary syndrome.
[So] Fuente:Medicine (Baltimore);97(2):e9579, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:OBJECTIVE: The aim of this study was to explore the clinical effects of remote ischemic preconditioning (RIPC) on contrast-induced nephropathy after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS). PATIENTS AND METHODS: The study was a single-center, prospective, randomized, controlled study. A total of 161 patients with ACS and the rate of estimate glomerular filtration (eGFR) 15 to 70 mL/min/1.73 m2 undergoing PCI were randomly assigned to RIPC group (induced by 4 times of 5-minute inflations of a blood pressure cuff to 200 mmHg around the upper arm, followed by 5-min intervals of reperfusion at 1 hour before PCI therapy) or control group (an uninflated cuff around the arm). Successful completion of the PCI eventually included 107 cases of patients, including 50 cases in the RIPC group and 57 cases in the control group. The level of serum creatinine (Scr), CystatinC (CysC), blood neutrophil gelatinase-associated lipocalin (NGAL), eGFR were measured in all patients at 6 AM before the day of PCI, and 4-hour NGAL, 24-hour CysC, 72-hour Scr, and eGFR after PCI in the 2 groups. The incidence of major adverse events in the kidney (including the incidence of CIN, the need for dialysis, or renal replacement therapy after using contrast agent) and the composite endpoint of cardiovascular events were recorded at 6 months after PCI. RESULTS: There were no statistically significant differences in baseline indicators between the 2 groups. Scr, CysC, and blood NGAL levels and the incidence of CIN in patients with RIPC group were significantly lower than those form the control group after PCI (P < .05), but there were no significant differences between the average value of eGFR and occurrence of Major cardiovascular events in the postoperative 6 months (P > .05). CONCLUSIONS: RIPC can reduce PCI-related CIN and protect renal function in patients with ACS. The benefits of these patients by RIPC may be related to the reduction of the NGAL and CysC.
[Mh] Términos MeSH primario: Síndrome Coronario Agudo/terapia
Medios de Contraste/toxicidad
Precondicionamiento Isquémico
Enfermedades Renales/inducido químicamente
Enfermedades Renales/terapia
Intervención Coronaria Percutánea
[Mh] Términos MeSH secundario: Síndrome Coronario Agudo/complicaciones
Síndrome Coronario Agudo/epidemiología
Síndrome Coronario Agudo/fisiopatología
Anciano
Biomarcadores/sangre
Femenino
Tasa de Filtración Glomerular
Seres Humanos
Incidencia
Precondicionamiento Isquémico/métodos
Enfermedades Renales/epidemiología
Enfermedades Renales/fisiopatología
Masculino
Intervención Coronaria Percutánea/efectos adversos
Extremidad Superior/irrigación sanguínea
[Pt] Tipo de publicación:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nombre de substancia:
0 (Biomarkers); 0 (Contrast Media)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180305
[Lr] Fecha última revisión:180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009579



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