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[PMID]: 23671733 [Au] Autor: Peixoto RD; Al-Barrak J; Lim H; Renouf D [Ad] Dirección: Renata D'Alpino Peixoto, Jasem Al-Barrak, Howard Lim, Daniel Renouf, Department of Medical Oncology, BC Cancer Agency, Vancouver, BC V5Z 4E6, Canada. [Ti] Título: Gastroesophageal cancer and retroperitoneal fibrosis: Two case reports and review of the literature. [So] Fuente: World J Gastrointest Oncol;5(3):68-70, 2013 Mar 15. [Is] ISSN: 1948-5204 [Cp] País de publicación: China [La] Idioma: eng [Ab] Resumen: Retroperitoneal fibrosis secondary to malignant disease is a rare condition associated with a dismal prognosis. We herein present the first ever reported case of retroperitoneal fibrosis related to esophageal adenocarcinoma in a 63-year-old patient who developed bilateral ureteral obstruction due to extensive retroperitoneal fibrosis 18 mo after having completed neoadjuvant chemoradation followed by surgery for a pT3N0 adenocarcinoma of the distal esophagus. We also report the case of a previously healthy woman who presented with bilateral ureteral obstruction and diffuse narrowing of the common biliary duct and was found to have extensive retroperitoneal fibrosis as a consequence of metastatic gastric adenocarcinoma. Both patients had poor performance status and were unsuitable for palliative chemotherapy. This paper shows that urinary and biliary obstructive symptoms might represent retroperitoneal fibrosis as a consequence of gastroesophageal malignancy. [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1305 [St] Status: In-Data-Review [do] DOI: 10.4251/wjgo.v5.i3.68

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[PMID]: 23671896 [Au] Autor: Nousia CS; Gouveris H; Giatromanolaki A; Katotomichelakis M; Ypsilantis P; Riga M; Sivridis E; Watelet JB; van Cauwenberge P; Danielides V [Ti] Título: Immunohistochemical studies of wound healing after monopolar electrocautery and ultrasound submucosal inferior nasal turbinate reduction in sheep. [So] Fuente: Rhinology;51(2):154-61, 2013 Jun. [Is] ISSN: 0300-0729 [Cp] País de publicación: Netherlands [La] Idioma: eng [Ab] Resumen: BACKGROUND: Extracellular matrix (ECM) proteins such as fibronectin and collagen III, enzymes such as matrix metalloproteinases and macrophages have been demonstrated to intervene in nasal and paranasal sinuses wound healing. AIM OF THE STUDY: To compare concentration of ECM proteins, enzymes and the recruitment of macrophages during wound repair after monopolar electrocautery in contrast with ultrasound submucosal surgical tissue reduction of inferior nasal turbinate (INT) tested in sheep. MATERIALS AND METHODS: Prospective controlled study in sheep. Immunostaining for collagen III, fibronectin, CD68 and matrix metalloproteinase-9 (MMP9) was applied in tissue specimens of INT mucosa after monopolar electrocoagulation (MEC) and ultrasound tissue reduction (UTR). Twelve INTs were studied 1, 3 and 8 weeks post-operatively in each interventional group (MEC and UTR) and 5 INTs were studied in animals of the control group (without surgery). The immunoreactivity was quantitatively graded between 0% to 100% immunoreactivity by a blinded senior pathologist. RESULTS: At the end of the study period collagen III, fibronectin and MMP9 were increased in both groups compared to the levels of the control group. When compared to control group, CD68 immunoreactivity was found higher in MEC group but not in UTR group. Fibronectin subepithelial immunoreactivity exhibited a substantial negative correlation with mucosal epithelial cell necrosis, a substantial positive correlation with fibrosis in MEC-treated specimens and a significant positive correlation with sinusoid engorgement in UTR-treated specimens. Collagen III tissue immunoreactivity showed a particularly significant negative correlation with sinusoid engorgement in MEC-treated specimens. CONCLUSION: Correlation of fibronectin and collagen III immunoreactivity to histopathologic findings suggests different ECM repair processes between MEC and UTR turbinate tissue reduction. The use of CD68 and MMP9 provides additional clues to the mode of actions of these techniques and to the molecular and cellular events of the nasal mucosa wound healing process. [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [St] Status: In-Data-Review [do] DOI: 10.4193/Rhin

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[PMID]: 23560762 [Au] Autor: Wen Z; Cai M; Mai Z; Chen Y; Geng D; Wang J [Ad] Dirección: Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University , Guangzhou , China. [Ti] Título: Protection of Renal Impairment by Angiotensin II Type 1 Receptor Blocker in Rats with Post-Infarction Heart Failure. [So] Fuente: Ren Fail;35(5):766-75, 2013. [Is] ISSN: 1525-6049 [Cp] País de publicación: England [La] Idioma: eng [Ab] Resumen: Renal impairment is a frequent accompaniment post-myocardial infarction (MI) heart failure. However, the mechanisms and predictors are yet poorly understood. The present study aimed to explore early markers for renal impairment and to test the hypothesis that angiotensin II type 1 receptor (AT1R) blocker exerted renoprotection by regulating local angiotensin II receptors post-MI heart failure. Sprague-Dawley rats underwent ligation of the left descending coronary artery and were treated with losartan (20 mg/kg/day) or vehicle for 3 or 9 weeks. Samples of urine, blood, and kidney were collected for assessment of renal function, histology, and protein changes. The current study revealed that blood cystatin C, rather than serum creatinine and blood urea nitrogen, as well as urine proteins, increased post-MI heart failure significantly. These changes were associated with increased immunohistochemical staining of AT1R and AT2R proteins, accompanied by increased renal fibrosis, tubular necrosis, and inflammatory cell infiltration. Treatment with losartan for MI rats significantly attenuated upregulated AT1R but not AT2R. Losartan also decreased blood cystatin C levels and attenuated renal fibrosis, tubular necrosis, and inflammatory cell infiltration. In conclusion, blood cystatin C may be a better marker for early renal impairment. AT1R blockers modulated local angiotensin II receptors, as well as inflammatory reaction and profibrotic effects, providing potential clinical application in the setting of cardiorenal syndrome post-MI. [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [St] Status: In-Data-Review [do] DOI: 10.3109/0886022X.2013.780561

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[PMID]: 23671668 [Au] Autor: Snodgrass SM; Cihil KM; Cornuet PK; Myerburg MM; Swiatecka-Urban A [Ad] Dirección: Division of Pediatric Pulmonology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America. [Ti] Título: Tgf-ß1 Inhibits Cftr Biogenesis and Prevents Functional Rescue of ΔF508-Cftr in Primary Differentiated Human Bronchial Epithelial Cells. [So] Fuente: PLoS One;8(5):e63167, 2013. [Is] ISSN: 1932-6203 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: CFTR is an integral transmembrane glycoprotein and a cAMP-activated Cl(-) channel. Mutations in the CFTR gene lead to Cystic Fibrosis (CF)-an autosomal recessive disease with majority of the morbidity and mortality resulting from airway infection, inflammation, and fibrosis. The most common disease-associated mutation in the CFTR gene-deletion of Phe508 (ΔF508) leads to a biosynthetic processing defect of CFTR. Correction of the defect and delivery of ΔF508-CFTR to the cell surface has been highly anticipated as a disease modifying therapy. Compared to promising results in cultured cell this approach was much less effective in CF patients in an early clinical trial. Although the cause of failure to rescue ΔF508-CFTR in the clinical trial has not been determined, presence of factor(s) that interfere with the rescue in vivo could be considered. The cytokine TGF-ß1 is frequently elevated in CF patients. TGF-ß1 has pleiotropic effects in different disease models and genetic backgrounds and little is known about TGF-ß1 effects on CFTR in human airway epithelial cells. Moreover, there are no published studies examining TGF-ß1 effects on the functional rescue of ΔF508-CFTR. Here we found that TGF-ß1 inhibits CFTR biogenesis by reducing mRNA levels and protein abundance in primary differentiated human bronchial epithelial (HBE) cells from non-CF individuals. TGF-ß1 inhibits CFTR biogenesis without compromising the epithelial phenotype or integrity of HBE cells. TGF-ß1 also inhibits biogenesis and impairs the functional rescue of ΔF508-CFTR in HBE cells from patients homozygous for the ΔF508 mutation. Our data indicate that activation of TGF-ß1 signaling may inhibit CFTR function in non-CF individuals and may interfere with therapies directed at correcting the processing defect of ΔF508-CFTR in CF patients. [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [St] Status: In-Data-Review [do] DOI: 10.1371/journal.pone.0063167

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[PMID]: 23671660 [Au] Autor: Burgstaller G; Oehrle B; Koch I; Lindner M; Eickelberg O [Ad] Dirección: Comprehensive Pneumology Center, University Hospital of the Ludwig-Maximilians-University Munich and Helmholtz Zentrum München, Member of the German Center for Lung Research, Munich, Germany. [Ti] Título: Multiplex Profiling of Cellular Invasion in 3D Cell Culture Models. [So] Fuente: PLoS One;8(5):e63121, 2013. [Is] ISSN: 1932-6203 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: To-date, most invasion or migration assays use a modified Boyden chamber-like design to assess migration as single-cell or scratch assays on coated or uncoated planar plastic surfaces. Here, we describe a 96-well microplate-based, high-content, three-dimensional cell culture assay capable of assessing invasion dynamics and molecular signatures thereof. On applying our invasion assay, we were able to demonstrate significant effects on the invasion capacity of fibroblast cell lines, as well as primary lung fibroblasts. Administration of epidermal growth factor resulted in a substantial increase of cellular invasion, thus making this technique suitable for high-throughput pharmacological screening of novel compounds regulating invasive and migratory pathways of primary cells. Our assay also correlates cellular invasiveness to molecular events. Thus, we argue of having developed a powerful and versatile toolbox for an extensive profiling of invasive cells in a 96-well format. This will have a major impact on research in disease areas like fibrosis, metastatic cancers, or chronic inflammatory states. [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [St] Status: In-Data-Review [do] DOI: 10.1371/journal.pone.0063121

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[PMID]: 23671589 [Au] Autor: Gómez-Morales MA; Ludovisi A; Amati M; Pozio E [Ad] Dirección: Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Rome, Italy. [Ti] Título: Validation of an Excretory/Secretory Antigen Based-Elisa for the Diagnosis of Opisthorchis felineus Infection in Humans from Low Trematode Endemic Areas. [So] Fuente: PLoS One;8(5):e62267, 2013. [Is] ISSN: 1932-6203 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: Since opisthorchiasis does not show pathognomonic signs or symptoms, physicians can have serious problems to make a differential diagnosis of this infection in non endemic areas, in particular when there is a simultaneous occurrence with other seasonal infections. Moreover, symptomatic infections due to O. felineus can last a few weeks and then the signs and symptoms disappear, but the worms survive in the bile ducts for years causing hepatobiliary diseases including hepatomegaly, cholangitis, fibrosis of the periportal system, cholecystitis, and gallstones. Consequently, an early diagnosis prevents chronicity and loss of working days. The detection of specific antibodies has been considered as a complementary tool to the fecal examination to establish the definitive diagnosis of this infection and for the follow up. Therefore the aim of this work was the development and validation of an enzyme-linked immunosorbent assay (ELISA) using excretory/secretory antigens (ESA) from O. felineus adult worms to detect anti-Opisthorchis IgG in human sera. A total of 370 human sera were tested: 144 sera from persons with a confirmed diagnosis of opisthorchiasis, 110 sera from healthy Italian people, and 116 sera from people with other parasitic or non-parasitic infections. Results were analyzed by receiver-operator characteristic (ROC) curve analysis. The accuracy of the test, calculated by the area under curve (AUC), yielded a 0.999 value, indicating the high performance of the test. The sensitivity was 100% (95% CI: 97.40% to 100%) and no false-negative sera were detected; the specificity was 99.09% (95% CI: 95.02% to 99.83%). The validated ELISA shows a good performance in terms of sensitivity, repeatability and reproducibility, and it is suitable to detect anti-Opisthorchis IgG in human sera for diagnostic purposes and for the follow up to assess the efficacy of drug treatment. [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [St] Status: In-Data-Review [do] DOI: 10.1371/journal.pone.0062267

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[PMID]: 23669470 [Au] Autor: Nozawa F; Yalniz M; Saruc M; Standop J; Egami H; Pour PM [Ad] Dirección: Eppley Institute for Research in Cancer and Allied Diseases. Omaha, NE, USA. ppour@unmc.edu. [Ti] Título: Effects of fungal pancreatic enzymes on the function of islet cells in Syrian golden hamsters. [So] Fuente: JOP;14(3):228-336, 2013. [Is] ISSN: 1590-8577 [Cp] País de publicación: Italy [La] Idioma: eng [Ab] Resumen: CONTEXT: Our previous studies showed that porcine pancreatic enzymes in Syrian golden hamsters with peripheral insulin resistance normalizes the plasma insulin level, reduces the size of enlarged islets and inhibits the increased DNA synthesis in the beta-cell of islets. OBJECTIVE: In order to exclude the possibility that these effects was attributed to some contaminants of this crude material, we tested the effect of purified fungal pancreatic enzyme (FPE) that contains primarily amylase and lipase without (FPE) and with addition of chymotrypsin (FPE+chy). MATERIAL AND METHODS: In a pilot study we tested the effect of different doses of FPE given in drinking water on insulin level, islet size and DNA synthesis of islet cells in hamsters with induced peripheral insulin resistance by a high fat diet. The most effective dose of FPE on these parameters was used in a long-term experiment with FPE and FPE+chy in hamsters fed a high-fat diet for 36 or 40 weeks. RESULTS: In the pilot study a dose of 2 g/kg body weight was found to be optimal for controlling the body weight, normalizing plasma insulin level, the size of islets, the DNA synthesis and the number of insulin cells in the islets. These data were produced in the long-term study, where steatorrhea was also inhibited. Addition of chymotrypsin had no effects on these parameters. CONCLUSION: Pancreatic lipase and amylase appear to be responsible for the observed effects and offer a safe and effective natural product for the treatment of pancreatic diseases, including acute pancreatitis, chronic pancreatic, cystic fibrosis and any conditions associated with peripheral insulin resistance, including obesity and type 2 diabetes. The possible mechanism of the action is discussed. [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [St] Status: In-Data-Review [do] DOI: 10.6092/1590-8577/903

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[PMID]: 23430799 [Au] Autor: Finkenstedt A; Schranz M; Bösch S; Karall D; Bürgi SS; Ensinger C; Drach M; Mayr JA; Janecke AR; Vogel W; Nachbaur D; Zoller H [Ad] Dirección: Department of Medicine II Gastroenterology and Hepatology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria. [Ti] Título: MNGIE Syndrome: Liver Cirrhosis Should Be Ruled Out Prior to Bone Marrow Transplantation. [So] Fuente: JIMD Rep;10:41-4, 2013. [Is] ISSN: 2192-8304 [Cp] País de publicación: Germany [La] Idioma: eng [Ab] Resumen: Mitochondrial neurogastrointestinal encephalopathy (MNGIE) is an autosomal recessive mitochondriopathy caused by loss-of-function mutations in the thymidine phosphorylase gene. The disease leads to premature death and is characterized by gastrointestinal dysmotility and cachexia, external ophthalmoplegia, a sensorimotor neuropathy, and leukoencephalopathy. Bone marrow transplantation (BMT) is the only potentially curative treatment that can achieve a sustained biochemical correction of the metabolic imbalances.We report a 23-year-old male homozygous for the c.866A > C, p.Glu289Ala mutation of the TYMP gene, who presented with fatty liver and cachexia. Laboratory examinations were unremarkable except for increased transaminase activities. Grade II fibrosis and steatosis was found in an initial and a follow-up liver biopsy 4 years later. Myeloablative conditioning and BMT was performed 10 years after initial presentation due to the progressive weight loss and polyneuropathy. Pre-transplant liver staging was normal except for an elevated transient elastography of 31.6 kPa. Severe ascites developed after transplantation and liver function deteriorated progressively to liver failure. Despite engraftment on day +15, the patient died on day +18 from liver failure. Autopsy revealed micronodular liver cirrhosis, and postmortem diagnosis of acute-on-chronic liver failure was done.This case illustrates the difficulties and importance of diagnosing liver cirrhosis in MNGIE. Before BMT, patients must be carefully evaluated by transient elastography, liver biopsy, or assessment of hepatic venous pressure gradient. In patients with liver cirrhosis, further studies should evaluate if liver transplantation may be an alternative to BMT. Considerable amounts of thymidine phosphorylase are expressed in liver tissue which may prevent accumulation of toxic metabolites. [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1305 [St] Status: In-Data-Review [do] DOI: 10.1007/8904_2012_199

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[PMID]: 23401096 [Au] Autor: Ding L; Dolgachev V; Wu Z; Liu T; Nakashima T; Wu Z; Ullenbruch M; Lukacs NW; Chen Z; Phan SH [Ad] Dirección: Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA. [Ti] Título: Essential role of stem cell factor-c-Kit signalling pathway in bleomycin-induced pulmonary fibrosis. [So] Fuente: J Pathol;230(2):205-14, 2013 Jun. [Is] ISSN: 1096-9896 [Cp] País de publicación: England [La] Idioma: eng [Ab] Resumen: Stem cell factor (SCF) and its receptor c-Kit have been implicated in tissue remodelling and fibrosis. Alveolar fibroblasts from patients with diffuse interstitial fibrosis secrete more SCF. However, its precise role remains unclear. In this study the potential role of the SCF-c-Kit axis in pulmonary fibrosis was examined. Fibrosis was induced by intratracheal instillation of bleomycin (BLM), which caused increased SCF levels in plasma, bronchoalveolar lavage fluid (BALF) and lung tissue, as well as increased expression by lung fibroblasts. These changes were accompanied by increased numbers of bone marrow-derived c-Kit(+) cells in the lung, with corresponding depletion in bone marrow. Both recombinant SCF and lung extracts from BLM-treated animals induced bone-marrow cell migration, which was blocked by c-Kit inhibitor. The migrated cells promoted myofibroblast differentiation when co-cultured with fibroblasts, suggesting a paracrine pathogenic role. Interestingly, lung fibroblast cultures contained a subpopulation of cells that expressed functionally active c-Kit, which were significantly greater and more responsive to SCF induction when isolated from fibrotic lungs, including those from patients with idiopathic pulmonary fibrosis (IPF). This c-Kit(+) subpopulation was αSMA-negative and expressed lower levels of collagen I but significantly higher levels of TGFß than c-Kit-negative cells. SCF deficiency achieved by intratracheal treatment with neutralizing anti-SCF antibody or by use of Kitl(Sl) /Kitl(Sl) (-d) mutant mice in vivo resulted in significant reduction in pulmonary fibrosis. Taken together, the SCF-c-Kit pathway was activated in BLM-injured lung and might play a direct role in pulmonary fibrosis by the recruitment of bone marrow progenitor cells capable of promoting lung myofibroblast differentiation. Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [St] Status: In-Data-Review [do] DOI: 10.1002/path.4177

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[PMID]: 23543337 [Au] Autor: Chibishev A; Pereska Z; Simonovska N; Chibisheva V; Glasnovic M; Chitkushev LT [Ad] Dirección: Toxicology Clinic, Clinical Center, School of Medicine, University "Ss Cyril and Metodius", Skopje, Republic of Macedonia, toksikourgentna@gmail.com. [Ti] Título: Conservative therapeutic approach to corrosive poisonings in adults. [So] Fuente: J Gastrointest Surg;17(6):1044-9, 2013 Jun. [Is] ISSN: 1873-4626 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: INTRODUCTION: In this study, we assess the effectiveness of a conservative therapeutic treatment of acute corrosive poisonings in adults, and we define therapeutic protocols based on clinical and endoscopic criteria. METHODS: We analyzed clinical records of patients with acute corrosive poisonings who were hospitalized and treated at the Toxicology Clinic at the University of Skopje, Republic of Macedonia, during a 5-year period (2006-2010). A total of 481 patients' records with cases of acute corrosive poisonings were analyzed. There were 317 female (65.9 %) and 164 male (34.1 %) patients. The purpose of the therapy in the cases of acute corrosive poisonings is to prevent perforation as well as progressive fibrosis and stenosis of the esophagus and stomach. Therapeutic approach mainly consists of proton pump inhibitors, H2 blockers, antibiotics, and intensive hyperalimentation. There are different opinions regarding conservative treatment of acute corrosive poisonings in adults. CONCLUSION: Based on our study of corrosive poisonings of adults, we propose a list of optimal treatment recommendations. [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1305 [Sb] Subgrupo de revista: IM [St] Status: In-Data-Review [do] DOI: 10.1007/s11605-013-2190-9

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