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[PMID]:29425202
[Au] Autor:Du M; Li N; Niu B; Liu Y; You D; Jiang D; Ruan C; Qin Z; Song T; Wang W
[Ad] Dirección:Key Lab for Quality, Efficient Cultivation and Security Control of Crops in Colleges and University of Yunnan Province, Honghe University, Mengzi, Yunnan Province, P.R. China.
[Ti] Título:De novo transcriptome analysis of Bagarius yarrelli (Siluriformes: Sisoridae) and the search for potential SSR markers using RNA-Seq.
[So] Fuente:PLoS One;13(2):e0190343, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:BACKGROUND: The yellow sisorid catfish (Bagarius yarrelli) is a carnivorous freshwater fish that inhabits the Honghe River, Lanchangjiang River and Nujiang River of southern China and other Southeast Asian countries. However, the publicly available genomic data for B. yarrelli are limited. METHODOLOGY AND PRINCIPAL FINDINGS: Illumina Solexa paired-end technology produced 1,706,456 raw reads from muscle, liver and caudal fin tissues of B. yarrelli. Nearly 5 Gb of data were acquired, and de novo assembly generated 14,607 unigenes, with an N50 of 2006 bp. A total of 9093 unigenes showed significant similarities to known proteins in public databases: 4477 and 6391 of B. yarrelli unigenes were mapped to the Gene Ontology (GO) and Clusters of Orthologous Groups (COG) databases, respectively. Moreover, 9635 unigenes were assigned to 242 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. In addition, 8568 microsatellites (simple sequence repeats, SSRs) were detected, and 31 pairs of polymorphic primers were characterized using wild populations of B. yarrelli from the Nujiang River, Yunnan Province, China. CONCLUSION/SIGNIFICANCE: These sequences enrich the genomic resources for B. yarrelli and will benefit future investigations into the evolutionary and biological processes of this and related Bagarius species. The SSR markers developed in this study will facilitate construction of genetic maps, investigations of genetic structures and germplasm polymorphism assessments in B. yarrelli.
[Mh] Términos MeSH primario: Bagres/genética
Marcadores Genéticos
Análisis de Secuencia de ARN
Transcriptoma
[Mh] Términos MeSH secundario: Animales
Repeticiones de Microsatélite/genética
Sistemas de Lectura Abierta
Reacción en Cadena de la Polimerasa
Polimorfismo Genético
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nombre de substancia:
0 (Genetic Markers)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180210
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190343


  2 / 75668 MEDLINE  
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[PMID]:29287879
[Au] Autor:Niu Z; Yan D; Bressler S; Mei L; Feng Y; Liu X
[Ad] Dirección:Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha 410008, China; Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
[Ti] Título:A novel splicing mutation in SMPX is linked to nonsyndromic progressive hearing loss.
[So] Fuente:Int J Pediatr Otorhinolaryngol;104:47-50, 2018 Jan.
[Is] ISSN:1872-8464
[Cp] País de publicación:Ireland
[La] Idioma:eng
[Ab] Resumen:OBJECTIVE: X-linked nonsyndromic hearing impairment is the rarest form of genetic hearing loss and represents only a minor fraction of all cases. The aim of this study was to investigate the cause of X-linked nonsyndromic sensorineural hearing loss in a three-generation American family. METHODS: Whole-exome sequencing and co-segregation analysis were used to identify disease-causing genes. RESULTS: In this study, we described in detail the clinical characteristics of the family and identified a novel frameshift mutation creating a premature stop codon (c.133-1 G > A, p.(Gly45fs*36)) of SMPX. The loss-of-function mutation was co-segregated with the progressive hearing loss phenotype and was absent in 200 normal controls. CONCLUSIONS: We report the first SMPX (DFNX4) mutation in a North American family. Our findings contribute to the existing genotypic and phenotypic spectrum of SMPX associated hearing loss. Furthermore, our data suggest that exome sequencing is promising in the genetic diagnosis of hearing loss.
[Mh] Términos MeSH primario: Sordera/genética
Enfermedades Genéticas Ligadas al Cromosoma X/genética
Pérdida Auditiva Sensorineural/genética
Proteínas Musculares/genética
[Mh] Términos MeSH secundario: Adolescente
Adulto
Anciano
Niño
Codón sin Sentido
Femenino
Mutación del Sistema de Lectura
Genotipo
Seres Humanos
Masculino
Mediana Edad
Linaje
Empalme del ARN
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Codon, Nonsense); 0 (Muscle Proteins); 0 (SMPX protein, human)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180309
[Lr] Fecha última revisión:180309
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:171231
[St] Status:MEDLINE


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[PMID]:29231021
[Au] Autor:Wang JJ; Liu C; Liu L; Zhang SY; Li HZ; Cai WX
[Ad] Dirección:Wenzhou Medical University, Wenzhou 325035, China.
[Ti] Título:[Eye Movement Characteristics of Cooperation Degree during Image Completion Test in Psychiatric Impairment Assessment].
[So] Fuente:Fa Yi Xue Za Zhi;33(2):154-157, 2017 Apr.
[Is] ISSN:1004-5619
[Cp] País de publicación:China
[La] Idioma:chi
[Ab] Resumen:OBJECTIVES: To explore the difference of eye movement characteristics between uncooperative and cooperative subjects with mental disorder after cerebral trauma. METHODS: Thirty-nine subjects which needed psychiatric impairment assessment were selected. According to the binomial forced-choice digit memory test (BFDMT), all subjects were divided into cooperative and uncooperative groups. The subjects were asked to take the image completion test from Wechsler adult intelligence scale. Meanwhile, the data of eye movement track, fixation, saccade, pupil and blink were recorded by the track system of eye movement. RESULTS: There were significantly differences ( <0.05) in the data of saccade between cooperative (10 cases) and uncooperative groups (29 cases). The frequency, time, amplitude, acceleration of saccadic in uncooperative group were significantly higher than cooperation group. The saccade latencies of cooperation group increased more than uncooperative group. There was a significant difference ( <0.05) in total discrete distance, average distance and total time of fixation between two groups, while the average duration time, number and frequency of fixation had no significantly difference ( >0.05) between two groups. And the blink frequency of cooperation group was higher than uncooperative group. CONCLUSIONS: Eye movement can be an objective index for the primary judgment of cooperation level.
[Mh] Términos MeSH primario: Movimientos Oculares/fisiología
Movimientos Sacádicos/fisiología
[Mh] Términos MeSH secundario: Adulto
Medidas del Movimiento Ocular
Seres Humanos
Pruebas de Inteligencia
Escalas de Wechsler
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180308
[Lr] Fecha última revisión:180308
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:171213
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2017.02.009


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[PMID]:28903484
[Au] Autor:Yang Y; Gao X; Zhang M; Yan S; Sun C; Xiao F; Huang N; Yang X; Zhao K; Zhou H; Huang S; Xie B; Zhang N
[Ad] Dirección:Department of Neurosurgery, The 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, PR China; Guangdong Provincial Key Laboratory of Pituitary Tumor, Guangzhou, Guangdong Province, PR China; Department of Scientific Research Section, The 1st Affiliated Hospital of Sun Y
[Ti] Título:Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis.
[So] Fuente:J Natl Cancer Inst;110(3), 2018 Mar 01.
[Is] ISSN:1460-2105
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Background: Circular RNAs (circRNAs) are RNA transcripts that are widespread in the eukaryotic genome. Recent evidence indicates that circRNAs play important roles in tissue development, gene regulation, and carcinogenesis. However, whether circRNAs encode functional proteins remains elusive, although translation of several circRNAs was recently reported. Methods: CircRNA deep sequencing was performed by using 10 pathologically diagnosed glioblastoma samples and their paired adjacent normal brain tissues. Northern blotting, Sanger sequencing, antibody, and liquid chromatograph Tandem Mass Spectrometer were used to confirm the existence of circ-FBXW7 and its encoded protein in in two cell lines. Lentivirus-transfected stable U251 and U373 cells were used to assess the biological functions of the novel protein invitro and invivo (five mice per group). Clinical implications of circ-FBXW7 were assessed in 38 pathologically diagnosed glioblastoma samples and their paired periphery normal brain tissues by using quantitative polymerase chain reaction (two-sided log-rank test). Results: Circ-FBXW7 is abundantly expressed in the normal human brain (reads per kilobase per million mapped reads [RPKM] = 9.31). The spanning junction open reading frame in circ-FBXW7 driven by internal ribosome entry site encodes a novel 21-kDa protein, which we termed FBXW7-185aa. Upregulation of FBXW7-185aa in cancer cells inhibited proliferation and cell cycle acceleration, while knockdown of FBXW7-185aa promoted malignant phenotypes invitro and invivo. FBXW7-185aa reduced the half-life of c-Myc by antagonizing USP28-induced c-Myc stabilization. Moreover, circ-FBXW7 and FBXW7-185aa levels were reduced in glioblastoma clinical samples compared with their paired tumor-adjacent tissues (P < .001). Circ-FBXW7 expression positively associated with glioblastoma patient overall survival (P = .03). Conclusions: Endogenous circRNA encodes a functional protein in human cells, and circ-FBXW7 and FBXW7-185aa have potential prognostic implications in brain cancer.
[Mh] Términos MeSH primario: Neoplasias Encefálicas/genética
Proteínas de Ciclo Celular/genética
Transformación Celular Neoplásica/genética
Proteínas F-Box/genética
Glioblastoma/genética
ARN/análisis
Ubiquitina-Proteína Ligasas/genética
[Mh] Términos MeSH secundario: Animales
Encéfalo/metabolismo
Neoplasias Encefálicas/química
Ciclo Celular/genética
Proteínas de Ciclo Celular/análisis
Línea Celular Tumoral
Proliferación Celular/genética
Proteínas F-Box/análisis
Proteína 7 que Contiene Repeticiones F-Box-WD
Femenino
Glioblastoma/química
Semivida
Seres Humanos
Ratones
Ratones Consanguíneos BALB C
Ratones Desnudos
Trasplante de Neoplasias
Sistemas de Lectura Abierta
Proteínas Proto-Oncogénicas c-myc/metabolismo
Análisis de Secuencia de ARN
Tasa de Supervivencia
Ubiquitina Tiolesterasa/metabolismo
Ubiquitina-Proteína Ligasas/análisis
Regulación hacia Arriba
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Cell Cycle Proteins); 0 (F-Box Proteins); 0 (F-Box-WD Repeat-Containing Protein 7); 0 (FBXW7 protein, human); 0 (Proto-Oncogene Proteins c-myc); 0 (RNA, circular); 63231-63-0 (RNA); EC 2.3.2.27 (Ubiquitin-Protein Ligases); EC 3.1.2.15 (USP28 protein, human); EC 3.4.19.12 (Ubiquitin Thiolesterase)
[Em] Mes de ingreso:1710
[Cu] Fecha actualización por clase:180308
[Lr] Fecha última revisión:180308
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170915
[St] Status:MEDLINE
[do] DOI:10.1093/jnci/djx166


  5 / 75668 MEDLINE  
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[PMID]:28458050
[Au] Autor:Rieth CA; Huber DE
[Ad] Dirección:Pacific Science and Engineering Group, Inc, United States.
[Ti] Título:Comparing different kinds of words and word-word relations to test an habituation model of priming.
[So] Fuente:Cogn Psychol;95:79-104, 2017 Jun.
[Is] ISSN:1095-5623
[Cp] País de publicación:Netherlands
[La] Idioma:eng
[Ab] Resumen:Huber and O'Reilly (2003) proposed that neural habituation exists to solve a temporal parsing problem, minimizing blending between one word and the next when words are visually presented in rapid succession. They developed a neural dynamics habituation model, explaining the finding that short duration primes produce positive priming whereas long duration primes produce negative repetition priming. The model contains three layers of processing, including a visual input layer, an orthographic layer, and a lexical-semantic layer. The predicted effect of prime duration depends both on this assumed representational hierarchy and the assumption that synaptic depression underlies habituation. The current study tested these assumptions by comparing different kinds of words (e.g., words versus non-words) and different kinds of word-word relations (e.g., associative versus repetition). For each experiment, the predictions of the original model were compared to an alternative model with different representational assumptions. Experiment 1 confirmed the prediction that non-words and inverted words require longer prime durations to eliminate positive repetition priming (i.e., a slower transition from positive to negative priming). Experiment 2 confirmed the prediction that associative priming increases and then decreases with increasing prime duration, but remains positive even with long duration primes. Experiment 3 replicated the effects of repetition and associative priming using a within-subjects design and combined these effects by examining target words that were expected to repeat (e.g., viewing the target word 'BACK' after the prime phrase 'back to'). These results support the originally assumed representational hierarchy and more generally the role of habituation in temporal parsing and priming.
[Mh] Términos MeSH primario: Habituación Psicofisiológica/fisiología
Modelos Psicológicos
Psicolingüística
Memoria Implícita/fisiología
[Mh] Términos MeSH secundario: Adulto
Seres Humanos
Lectura
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180307
[Lr] Fecha última revisión:180307
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170502
[St] Status:MEDLINE


  6 / 75668 MEDLINE  
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[PMID]:29451669
[Au] Autor:Celeste LC; Pereira ES; Pereira NRR; Alves LM
[Ad] Dirección:Universidade de Brasília, Brasília, DF, Brasil.
[Ti] Título:Prosodic parameters of reading in 2nd to 5th grade students.
[Ti] Título:Parâmetros prosódicos de leitura em escolares do segundo ao quinto ano do ensino fundamental..
[So] Fuente:Codas;30(1):e20170034, 2018.
[Is] ISSN:2317-1782
[Cp] País de publicación:Brazil
[La] Idioma:eng; por
[Ab] Resumen:Purpose Characterize and compare melodic variation and reading speed and verify their evolution throughout the development of schooling. Methods The reading of 78 Elementary School (2nd to 5th grade) students was analyzed using the Praat program with regards to the parameters of melodic variation (F0) and reading speed (Duration). Statistical measures (mean and standard deviation) were taken and the Student´s t-test was applied at significance level of 5%. Results Melodic variation and reading speed increased as schooling progressed, especially during 5th grade. Conclusion Melodic variation increases as schooling progresses, mainly during 5th grade. First minute of reading analysis is sufficient to assess reading speed, not being necessary to analyze the full text.
[Mh] Términos MeSH primario: Lectura
[Mh] Términos MeSH secundario: Niño
Comprensión
Evaluación Educacional
Seres Humanos
Lenguaje
Habla/fisiología
Estudiantes
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180306
[Lr] Fecha última revisión:180306
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180217
[St] Status:MEDLINE


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[PMID]:29376563
[Au] Autor:Martin A; Booth JN; Laird Y; Sproule J; Reilly JJ; Saunders DH
[Ad] Dirección:Centre for Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, Edinburgh, UK, EH8 9AG.
[Ti] Título:Physical activity, diet and other behavioural interventions for improving cognition and school achievement in children and adolescents with obesity or overweight.
[So] Fuente:Cochrane Database Syst Rev;1:CD009728, 2018 01 29.
[Is] ISSN:1469-493X
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:BACKGROUND: The global prevalence of childhood and adolescent obesity is high. Lifestyle changes towards a healthy diet, increased physical activity and reduced sedentary activities are recommended to prevent and treat obesity. Evidence suggests that changing these health behaviours can benefit cognitive function and school achievement in children and adolescents in general. There are various theoretical mechanisms that suggest that children and adolescents with excessive body fat may benefit particularly from these interventions. OBJECTIVES: To assess whether lifestyle interventions (in the areas of diet, physical activity, sedentary behaviour and behavioural therapy) improve school achievement, cognitive function (e.g. executive functions) and/or future success in children and adolescents with obesity or overweight, compared with standard care, waiting-list control, no treatment, or an attention placebo control group. SEARCH METHODS: In February 2017, we searched CENTRAL, MEDLINE and 15 other databases. We also searched two trials registries, reference lists, and handsearched one journal from inception. We also contacted researchers in the field to obtain unpublished data. SELECTION CRITERIA: We included randomised and quasi-randomised controlled trials (RCTs) of behavioural interventions for weight management in children and adolescents with obesity or overweight. We excluded studies in children and adolescents with medical conditions known to affect weight status, school achievement and cognitive function. We also excluded self- and parent-reported outcomes. DATA COLLECTION AND ANALYSIS: Four review authors independently selected studies for inclusion. Two review authors extracted data, assessed quality and risks of bias, and evaluated the quality of the evidence using the GRADE approach. We contacted study authors to obtain additional information. We used standard methodological procedures expected by Cochrane. Where the same outcome was assessed across different intervention types, we reported standardised effect sizes for findings from single-study and multiple-study analyses to allow comparison of intervention effects across intervention types. To ease interpretation of the effect size, we also reported the mean difference of effect sizes for single-study outcomes. MAIN RESULTS: We included 18 studies (59 records) of 2384 children and adolescents with obesity or overweight. Eight studies delivered physical activity interventions, seven studies combined physical activity programmes with healthy lifestyle education, and three studies delivered dietary interventions. We included five RCTs and 13 cluster-RCTs. The studies took place in 10 different countries. Two were carried out in children attending preschool, 11 were conducted in primary/elementary school-aged children, four studies were aimed at adolescents attending secondary/high school and one study included primary/elementary and secondary/high school-aged children. The number of studies included for each outcome was low, with up to only three studies per outcome. The quality of evidence ranged from high to very low and 17 studies had a high risk of bias for at least one item. None of the studies reported data on additional educational support needs and adverse events.Compared to standard practice, analyses of physical activity-only interventions suggested high-quality evidence for improved mean cognitive executive function scores. The mean difference (MD) was 5.00 scale points higher in an after-school exercise group compared to standard practice (95% confidence interval (CI) 0.68 to 9.32; scale mean 100, standard deviation 15; 116 children, 1 study). There was no statistically significant beneficial effect in favour of the intervention for mathematics, reading, or inhibition control. The standardised mean difference (SMD) for mathematics was 0.49 (95% CI -0.04 to 1.01; 2 studies, 255 children, moderate-quality evidence) and for reading was 0.10 (95% CI -0.30 to 0.49; 2 studies, 308 children, moderate-quality evidence). The MD for inhibition control was -1.55 scale points (95% CI -5.85 to 2.75; scale range 0 to 100; SMD -0.15, 95% CI -0.58 to 0.28; 1 study, 84 children, very low-quality evidence). No data were available for average achievement across subjects taught at school.There was no evidence of a beneficial effect of physical activity interventions combined with healthy lifestyle education on average achievement across subjects taught at school, mathematics achievement, reading achievement or inhibition control. The MD for average achievement across subjects taught at school was 6.37 points lower in the intervention group compared to standard practice (95% CI -36.83 to 24.09; scale mean 500, scale SD 70; SMD -0.18, 95% CI -0.93 to 0.58; 1 study, 31 children, low-quality evidence). The effect estimate for mathematics achievement was SMD 0.02 (95% CI -0.19 to 0.22; 3 studies, 384 children, very low-quality evidence), for reading achievement SMD 0.00 (95% CI -0.24 to 0.24; 2 studies, 284 children, low-quality evidence), and for inhibition control SMD -0.67 (95% CI -1.50 to 0.16; 2 studies, 110 children, very low-quality evidence). No data were available for the effect of combined physical activity and healthy lifestyle education on cognitive executive functions.There was a moderate difference in the average achievement across subjects taught at school favouring interventions targeting the improvement of the school food environment compared to standard practice in adolescents with obesity (SMD 0.46, 95% CI 0.25 to 0.66; 2 studies, 382 adolescents, low-quality evidence), but not with overweight. Replacing packed school lunch with a nutrient-rich diet in addition to nutrition education did not improve mathematics (MD -2.18, 95% CI -5.83 to 1.47; scale range 0 to 69; SMD -0.26, 95% CI -0.72 to 0.20; 1 study, 76 children, low-quality evidence) and reading achievement (MD 1.17, 95% CI -4.40 to 6.73; scale range 0 to 108; SMD 0.13, 95% CI -0.35 to 0.61; 1 study, 67 children, low-quality evidence). AUTHORS' CONCLUSIONS: Despite the large number of childhood and adolescent obesity treatment trials, we were only able to partially assess the impact of obesity treatment interventions on school achievement and cognitive abilities. School and community-based physical activity interventions as part of an obesity prevention or treatment programme can benefit executive functions of children with obesity or overweight specifically. Similarly, school-based dietary interventions may benefit general school achievement in children with obesity. These findings might assist health and education practitioners to make decisions related to promoting physical activity and healthy eating in schools. Future obesity treatment and prevention studies in clinical, school and community settings should consider assessing academic and cognitive as well as physical outcomes.
[Mh] Términos MeSH primario: Logro
Escolaridad
Ejercicio
Estilo de Vida
Sobrepeso/terapia
Obesidad Pediátrica/terapia
[Mh] Términos MeSH secundario: Adolescente
Niño
Función Ejecutiva
Seres Humanos
Matemática
Sobrepeso/psicología
Obesidad Pediátrica/psicología
Ensayos Clínicos Controlados Aleatorios como Asunto
Lectura
Sensibilidad y Especificidad
[Pt] Tipo de publicación:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180302
[Lr] Fecha última revisión:180302
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180130
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD009728.pub3


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[PMID]:28964886
[Au] Autor:Zhuang Y; Clamp JC; Yi Z; Ji D
[Ad] Dirección:Ocean School, Yantai University, Yantai 264005, China.
[Ti] Título:Phylogeny of the families Zoothamniidae and Epistylididae (Protozoa: Ciliophora: Peritrichia) based on analyses of three rRNA-coding regions.
[So] Fuente:Mol Phylogenet Evol;118:99-107, 2018 Jan.
[Is] ISSN:1095-9513
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Peritrichs are a major group of ciliates with worldwide distribution, and they play important roles in many habitats. Intrafamilial phylogeny of some peritrichs was investigated using information from three genes, which provided more robust interpretations than single-gene analyses. Sixty-seven new sequences including SSU rDNA, ITS1-5.8S-ITS2 and LSU rDNA were aligned with available sequences in GenBank to infer phylogenetic relationships within the families Zoothamniidae and Epistylididae. Results reveal the following relationships: (1) Epistylididae is polyphyletic, consisting of two clades that nest within the Zoothamniidae as part of the crown clade of peritrichs (order Vorticellida) and a third one that is part of the basal clade of peritrichs (order Opercularida); (2) Epistylis elongata falls within one of the clades of Zoothamnium rather than with congeners; (3) Zoothamnium is probably paraphyletic, consisting of three divergent clades, with the genera Myoschiston and Zoothamnopsis intermingled with species of Zoothamnium. The following evolutionary hypotheses can be inferred from these results: (1) the contractile stalk of Zoothamnium is plesiomorphic. (2) Myoschiston, Zoothamnopsis and clade II of Epistylididae are derived from the Zoothamnium morphotype by partial or incomplete development of the spasmoneme that forms the contractile center of the stalk around which the rigid cortex is secreted. (3) Clade I of the Epistylididae, which are primarily colonial forms that appear never to have evolved a spasmoneme of any sort, may represent the ancestral morphotype of peritrichs.
[Mh] Términos MeSH primario: Cilióforos/clasificación
Sistemas de Lectura Abierta/genética
Filogenia
ARN Ribosómico/genética
[Mh] Términos MeSH secundario: Secuencia de Bases
China
Cilióforos/genética
ADN Protozoario/genética
ADN Ribosómico/genética
Geografía
Funciones de Verosimilitud
Subunidades Ribosómicas Pequeñas/genética
Especificidad de la Especie
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (DNA, Protozoan); 0 (DNA, Ribosomal); 0 (RNA, Ribosomal)
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180302
[Lr] Fecha última revisión:180302
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:171002
[St] Status:MEDLINE


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[PMID]:28459906
[Au] Autor:Morgan DJ; Leppin AL; Smith CD; Korenstein D
[Ad] Dirección:VA Maryland Healthcare System, University of Maryland School of Medicine and Centers for Disease Dynamics, Economics, and Policy, Baltimore, MD.
[Ti] Título:A Practical Framework for Understanding and Reducing Medical Overuse: Conceptualizing Overuse Through the Patient-Clinician Interaction.
[So] Fuente:J Hosp Med;12(5):346-351, 2017 May.
[Is] ISSN:1553-5606
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Overuse of medical services is an increasingly recognized driver of poor-quality care and high cost. A practical framework is needed to guide clinical decisions and facilitate concrete actions that can reduce overuse and improve care. We used an iterative, expert-informed, evidence-based process to develop a framework for conceptualizing interventions to reduce medical overuse. Given the complexity of defining and identifying overused care in nuanced clinical situations and the need to define care appropriateness in the context of an individual patient, this framework conceptualizes the patient-clinician interaction as the nexus of decisions regarding inappropriate care. This interaction is influenced by other utilization drivers, including healthcare system factors, the practice environment, the culture of professional medicine, the culture of healthcare consumption, and individual patient and clinician factors. The variable strength of the evidence supporting these domains highlights important areas for further investigation. Journal of Hospital Medicine 2017;12:346-351.
[Mh] Términos MeSH primario: Comprensión
Prestación de Atención de Salud/normas
Prestación de Atención de Salud/utilización
Uso Excesivo de los Servicios de Salud/prevención & control
Relaciones Médico-Paciente
Calidad de la Atención de Salud/normas
[Mh] Términos MeSH secundario: Prestación de Atención de Salud/economía
Costos de la Atención en Salud/normas
Seres Humanos
Uso Excesivo de los Servicios de Salud/economía
Calidad de la Atención de Salud/economía
[Pt] Tipo de publicación:JOURNAL ARTICLE; REVIEW
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180302
[Lr] Fecha última revisión:180302
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170502
[St] Status:MEDLINE
[do] DOI:10.12788/jhm.2738


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[PMID]:28453422
[Au] Autor:Delwiche FA
[Ad] Dirección:a Dana Medical Library , University of Vermont , Burlington , Vermont , USA.
[Ti] Título:Health Sciences Library Support of a University Common Reading Program: A Case Study.
[So] Fuente:Med Ref Serv Q;36(2):150-164, 2017 Apr-Jun.
[Is] ISSN:1540-9597
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Common reading programs have become increasingly popular on college and university campuses as a means for increasing student engagement, retention, and success. This article describes the characteristics, goals, and benefits of common reading programs and provides examples from the literature of academic library involvement in them. Finally, an example is provided of how one academic health sciences library participated in its institution's First-Year Summer Reading program.
[Mh] Términos MeSH primario: Bibliotecas Médicas
Lectura
Universidades
[Mh] Términos MeSH secundario: Seres Humanos
Estudios de Casos Organizacionales
Estudiantes
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1803
[Cu] Fecha actualización por clase:180302
[Lr] Fecha última revisión:180302
[Sb] Subgrupo de revista:H
[Da] Fecha de ingreso para procesamiento:170429
[St] Status:MEDLINE
[do] DOI:10.1080/02763869.2017.1293980



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