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  1 / 2735 MEDLINE  
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[PMID]:29288667
[Au] Autor:Oishi K; Ohyama S; Higo-Yamamoto S
[Ad] Dirección:Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan; Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan. Electronic address: k-ooishi@aist.go.jp.
[Ti] Título:Chronic sleep disorder induced by psychophysiological stress induces glucose intolerance without adipose inflammation in mice.
[So] Fuente:Biochem Biophys Res Commun;495(4):2616-2621, 2018 01 22.
[Is] ISSN:1090-2104
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Sleep disturbances are associated with various metabolic diseases such as hypertension and diabetes. We had previously established a mouse model of a psychophysiological stress-induced chronic sleep disorder (CSD) characterized by disrupted circadian rhythms of wheel-running activity, core body temperature, and sleep-wake cycles. To evaluate the underlying mechanisms of metabolic disorders induced by CSD, we created mice with CSD for six weeks and fed them with a high-fat diet. Glucose intolerance with hyperglycemia resulted, although plasma insulin levels and body weight increases were identical between control and CSD mice. Gluconeogenesis and glycolysis were enhanced and suppressed, respectively, in the livers of CSD mice, because the mRNA expression of Pck1 was significantly increased, whereas that of Gck and Pklr were significantly decreased in the CSD mice. Adipose inflammation induced by the high-fat diet seemed suppressed by the CSD, because the mRNA expression levels of Adgre1, Ccl2, and Tnf were significantly downregulated in the adipose tissues of CSD mice. These findings suggest that CSD impair glucose tolerance by inducing gluconeogenesis and suppressing glycolysis. Hyperphasia with hypoleptinemia, hypercorticosteronemia, and increased plasma free fatty acids might be involved in the impaired glucose metabolism under a CSD. Further studies are needed to elucidate the endocrine and molecular mechanisms underlying the associations between sleep disorders and impaired glucose homeostasis that consequently causes diabetes.
[Mh] Términos MeSH primario: Intolerancia a la Glucosa/etiología
Intolerancia a la Glucosa/fisiopatología
Trastornos del Sueño-Vigilia/etiología
Trastornos del Sueño-Vigilia/fisiopatología
Estrés Psicológico/complicaciones
Estrés Psicológico/fisiopatología
[Mh] Términos MeSH secundario: Animales
Enfermedad Crónica
Citocinas/metabolismo
Masculino
Ratones
Paniculitis/etiología
Paniculitis/fisiopatología
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nombre de substancia:
0 (Cytokines)
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180222
[Lr] Fecha última revisión:180222
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:171231
[St] Status:MEDLINE


  2 / 2735 MEDLINE  
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[PMID]:29469793
[Au] Autor:Benavente-Villegas F; Ferrando-Roca F; Dolz-Gaitón R; Royo-Peiró M
[Ad] Dirección:Department of Dermatology, Dermatologist, Hospital Universitario Doctor Peset, Valencia, Spain. elipecbv@gmail.com.
[Ti] Título:Lesiones subcutáneas dolorosas en paciente con melanoma metastásico: un caso de paniculitis linfocítica asociado a vemurafenib.
[So] Fuente:Dermatol Online J;23(10), 2017 Oct 15.
[Is] ISSN:1087-2108
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Vemurafenib ha probado ser una herramienta útil en el tratamiento de melanoma metastásico con mutación BRAF-V600E. Los efectos adversos incluyen artralgias, fatiga y toxicidad cutánea, siendo infrecuente la paniculitis. Presentamos el caso de una paciente de 43 años con melanoma metastásico que desarrolla lesiones subcutáneas dolorosas en miembros inferiores y superiores, asociadas a clínica sistémica después de 2 semanas de inicio de tratamiento con Vemurafenib + Cobimetinib. La histología demostró paniculitis linfocitaria septal y lobulillar. La paciente tuvo mala tolerancia al tratamiento anti diana a dosis plenas, requiriendo su ajuste, generando una corticodependencia para controlar sintomatología, y que finalmente obligó a la descontinuación de la terapia dirigida contra melanoma.  A la fecha, se han descrito 29 casos en la literatura de paniculitis asociada a vemurafenib, siendo la mayoría paniculitis neutrofílicas con adecuado control de sintomatología asociando antiinflamatorios no esteroidales y/o corticoides orales sin requerir en su mayoría modificación de la terapia contra melanoma; sin embargo hay que tener presente que pueden haber casos con mala evolución que obligan a la reducción de dosis de vemurafenib y descontinuar el tratamiento, como ha ocurrido en nuestro reporte.Vemurafenib has proven to be a useful tool in the treatment of metastatic melanoma with BRAF-V600E mutation. Adverse effects include arthralgia, fatigue, and skin toxicity; panniculitis is a rare complication. We present the case of a 43-year-old patient with metastatic melanoma who developed painful subcutaneous nodules of the lower and upper limbs and associated systemic clinical symptoms after 2 weeks of treatment with vemurafenib plus cobimetinib. Histology showed a septal and lobular lymphocytic panniculitis.The patient had poor tolerance of the full-dose treatment, requiring its adjustment. Systemic corticosteroids were required to control symptomatology, which finally forced the discontinuation of the medication.To date, 29 cases have been described in the literature of panniculitis associated with vemurafenib. Most of these have been neutrophilic panniculitis, but adequate control of symptoms is usually achieved with nonsteroidal anti-inflammatory drugs and/or oral corticosteroids without requiring modification of melanoma therapy. However, it must be borne in mind that there may be cases that force the reduction and discontinuation ofvemurafenib treatment. We believe that this histological variant of lymphocytic panniculitis and its poor response to decrease in vemurafenib makes this case unusual and instructive.
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180222
[Lr] Fecha última revisión:180222
[St] Status:In-Process


  3 / 2735 MEDLINE  
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[PMID]:29390478
[Au] Autor:Mizuno S; Wakui M; Machida Y; Hosoe N; Hisamatsu T; Ishida T; Kameyama K; Naganuma M; Kanai T
[Ad] Dirección:Division of Gastroenterology and Hepatology, Department of Internal Medicine.
[Ti] Título:Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients: A case report.
[So] Fuente:Medicine (Baltimore);96(51):e9237, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:RATIONALE: Mesenteric panniculitis (MP) is a rare disease with abdominal and systemic symptoms and is characterized by nonspecific inflammation, fat necrosis, and fibrosis in mesenteric fat. Active inflammatory responses may increase levels of prostaglandin E-major urinary metabolite (PGE-MUM), which was reported to reflect the disease activity of ulcerative colitis and chronic fibrosing interstitial pneumonia. We recently experienced a case with elevated PGE-MUM at the time of diagnosis of MP and we investigated the potential of PGE-MUM as a biomarker. PATIENT CONCERN: In this report we described 2 active mesenteric panniculitis patients with high PGE-MUM levels. DIAGNOSES: Mesenteric panniculitis INTERVENTIONS:: Both MP patients were measured the levels of PGE-MUM. OUTCOMES: Both MP patients exhibited high levels of PGE-MUM before treatment. In one, the levels were sensitively correlated with clinical symptoms and serological markers on steroids. LESSONS: The study observations suggest the potential of PGE-MUM to reflect the disease activity of MP. To verify its use, more findings based on clinical studies should be accumulated.
[Mh] Términos MeSH primario: Corticoesteroides/uso terapéutico
Paniculitis Peritoneal/tratamiento farmacológico
Paniculitis Peritoneal/metabolismo
Prostaglandinas E/metabolismo
[Mh] Términos MeSH secundario: Anciano
Biomarcadores/metabolismo
Femenino
Estudios de Seguimiento
Seres Humanos
Masculino
Mediana Edad
Paniculitis Peritoneal/orina
Medición de Riesgo
Índice de Severidad de la Enfermedad
Resultado del Tratamiento
Urinálisis
[Pt] Tipo de publicación:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nombre de substancia:
0 (Adrenal Cortex Hormones); 0 (Biomarkers); 0 (Prostaglandins E)
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180214
[Lr] Fecha última revisión:180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009237


  4 / 2735 MEDLINE  
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[PMID]:29197574
[Au] Autor:Li C; Li S; Zhang F; Wu M; Liang H; Song J; Lee C; Chen H
[Ad] Dirección:Department of Cardiology, Peking University People's Hospital, Beijing, 100044, China; Beijing Key Laboratory of Early Prediction and Intervention of Acute Myocardial Infarction, Peking University People's Hospital, Beijing, 100044, China; Center for Cardiovascular Translational Research, Peking Uni
[Ti] Título:Endothelial microparticles-mediated transfer of microRNA-19b promotes atherosclerosis via activating perivascular adipose tissue inflammation in apoE mice.
[So] Fuente:Biochem Biophys Res Commun;495(2):1922-1929, 2018 01 08.
[Is] ISSN:1090-2104
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Microparticles(MPs) are the major carriers of circulating microRNAs. Our previous study has shown that microRNA (miR)-19b in endothelial cell-derived microparticles (EMPs) is significantly increased in patients with unstable angina. However, little is known about the relationship between miR-19b in EMPs and the progression of atherosclerosis. The aim of the present study was to define the role and potential mechanism of miR-19b incorporated in EMPs in the development of atherosclerosis. Western-diet-fed apoE mice were injected with phosphate buffered solution(PBS), EMP carrying microRNA control(EMP ) or miR-19b mimic (EMP ) intravenously. Systemic treatment with EMP significantly accelerated carotid artery atherosclerosis progression by increasing lipid, macrophages and smooth muscle cells and decreasing collagen content in atherosclerotic plaque. Fluorescence-labelled EMP injection proved that miR-19b could be transported into perivascular adipose tissue(PVAT) by EMPs. EMP treatment also promoted inflammatory cytokines secretion and macrophages infiltration in PVAT. In further experiment, apoE mice were divided into 3 groups: EMP PVAT(+), EMP PVAT(+) and EMP PVAT(-), based on removing or keeping pericarotid adipose tissue and injected with EMP or EMP . Loss of PVAT attenuated EMP -mediated effects on increasing carotid atherosclerosis formation and inflammatory cytokines level in plaque. EMP inhibited suppressor of cytokine signaling 3 (SOCS3) expression in PVAT. Our findings demonstrate that miR-19b in EMPs exaggerates atherosclerosis progression by augmenting PVAT-specific inflammation proceeded by downregulating SOCS3 expression.
[Mh] Términos MeSH primario: Tejido Adiposo/inmunología
Aterosclerosis/inmunología
Micropartículas Derivadas de Células/inmunología
Endotelio Vascular/inmunología
MicroARNs/inmunología
Paniculitis/inmunología
[Mh] Términos MeSH secundario: Animales
Apolipoproteínas E/genética
Masculino
Ratones
Ratones Noqueados
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nombre de substancia:
0 (Apolipoproteins E); 0 (MIRN19 microRNA, mouse); 0 (MicroRNAs)
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180214
[Lr] Fecha última revisión:180214
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:171204
[St] Status:MEDLINE


  5 / 2735 MEDLINE  
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[PMID]:29298971
[Au] Autor:Kobayashi H; Notohara K; Otsuka T; Kobayashi Y; Ujita M; Yoshioka Y; Suzuki N; Aoyagi R; Ohashi R; Suzuki T
[Ad] Dirección:Department of Pathology, Tachikawa General Hospital, Nagaoka, Niigata, Japan.
[Ti] Título:An Autopsy Case of Mesenteric Panniculitis with Massive Pleural Effusions.
[So] Fuente:Am J Case Rep;19:13-20, 2018 Jan 04.
[Is] ISSN:1941-5923
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:BACKGROUND Mesenteric panniculitis (MP) is an idiopathic chronic inflammatory condition of the mesentery. The main symptoms include abdominal pain, abdominal distention, weight loss, fever, nausea, and vomiting. The patients also present with chylous ascites in 14% of the cases and chylous pleural effusion (CPE) in very rare occasions. Despite the previous view of excellent prognosis of MP, two recent papers reported several fatal cases. However, there are still only a few autopsy case reports that describe the macroscopic and histological details of MP cases. CASE REPORT The patient was an 81-year-old Japanese woman. She complained of edema of her lower legs and face, general fatigue, and dyspnea. She was overweight and had type 2 diabetes (T2D). Computerized tomography (CT) demonstrated massive bilateral pleural effusions, with mild pericardial effusion and mild ascites. There was no pulmonary, cardiac or hepatic condition to explain the effusions. However, MP was suspected based on her CT. She gradually deteriorated into respiratory failure. The autopsy revealed CPEs (left 1,300 mL, right 1,400 mL) and MP in the mesentery of the small intestine. Neither neoplasia nor inflammatory conditions other than MP were detected. CONCLUSIONS In rare occasions, patients with MP present with CPE or chylothorax. We thought that a possible mechanism of the CPEs was a diaphragmatic defect. We suspected that being overweight and T2D had an etiological relationship with MP in our patient's case. Adipose tissue of the mesentery is the main focus of MP. We believed that MP would be the best umbrella term of the many synonyms.
[Mh] Términos MeSH primario: Autopsia
Paniculitis Peritoneal/complicaciones
Derrame Pleural/etiología
[Mh] Términos MeSH secundario: Anciano de 80 o más Años
Índice de Masa Corporal
Cadáver
Diabetes Mellitus Tipo 2/complicaciones
Femenino
Seres Humanos
Sobrepeso/complicaciones
Paniculitis Peritoneal/patología
Derrame Pleural/patología
Factores de Riesgo
[Pt] Tipo de publicación:CASE REPORTS; JOURNAL ARTICLE
[Em] Mes de ingreso:1802
[Cu] Fecha actualización por clase:180205
[Lr] Fecha última revisión:180205
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:180105
[St] Status:MEDLINE


  6 / 2735 MEDLINE  
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[PMID]:29072952
[Au] Autor:Hathuc VM; Hristov AC; Smith LB
[Ad] Dirección:From the Sections of Hematopathology (Drs Hathuc and Smith) and Dermatopathology (Dr Hristov) in the Department of Pathology, University of Michigan Medical Center, Ann Arbor.
[Ti] Título:Primary Cutaneous Acral CD8 T-Cell Lymphoma.
[So] Fuente:Arch Pathol Lab Med;141(11):1469-1475, 2017 Nov.
[Is] ISSN:1543-2165
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Primary cutaneous acral CD8 T-cell lymphoma is a new provisional entity in the 2016 revision of the World Health Organization classification of lymphoid neoplasms. This is a challenging diagnosis because of its rarity, as well as its morphologic and immunophenotypic overlap with other CD8 cytotoxic lymphoid proliferations. Appropriate classification of this entity is crucial because of its indolent clinical behavior compared with other CD8 T-cell lymphomas. Knowledge of the clinical setting, sites of involvement, and morphologic features can aid in correct diagnosis. Here, we review the clinical and pathologic features of primary cutaneous acral CD8 T-cell lymphoma with an emphasis on the differential diagnosis among other C8 T-cell lymphomas.
[Mh] Términos MeSH primario: Linfocitos T CD8-positivos/patología
Linfoma Cutáneo de Células T/diagnóstico
[Mh] Términos MeSH secundario: Biomarcadores de Tumor/metabolismo
Linfocitos T CD8-positivos/metabolismo
Diagnóstico Diferencial
Extremidades
Seres Humanos
Inmunohistoquímica/tendencias
Inmunofenotipificación/tendencias
Linfoma de Células T/diagnóstico
Linfoma de Células T/metabolismo
Linfoma de Células T/patología
Linfoma Cutáneo de Células T/metabolismo
Linfoma Cutáneo de Células T/patología
Linfoma Cutáneo de Células T/terapia
Paniculitis/diagnóstico
Paniculitis/metabolismo
Paniculitis/patología
Pronóstico
[Pt] Tipo de publicación:JOURNAL ARTICLE; REVIEW
[Nm] Nombre de substancia:
0 (Biomarkers, Tumor)
[Em] Mes de ingreso:1711
[Cu] Fecha actualización por clase:171106
[Lr] Fecha última revisión:171106
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:171027
[St] Status:MEDLINE
[do] DOI:10.5858/arpa.2017-0230-RA


  7 / 2735 MEDLINE  
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[PMID]:28979630
[Au] Autor:Gomes DC; Quaresma L
[Ad] Dirección:Surgery Service, Hospital Center Lisboa Central, Lisboa, Portugal.
[Ti] Título:Sclerosing mesenteritis: a benign cause of mesenteric mass lesions.
[So] Fuente:Pan Afr Med J;27:228, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicación:Uganda
[La] Idioma:eng
[Ab] Resumen:Sclerosing mesenteritis is a rare disease of the mesentery. Associations with surgery, trauma, autoimmunity and paraneoplastic syndrome have been suggested, but most of the cases remain idiopathic. Diagnosis is often incidental, based upon the finding of a single or multiple mesenteric lesions on abdominal CT and histopathological confirmation. Optimal treatment is still controversial, but most of the cases reported have a favourable prognosis. We present a case of a 54-year-old male with long-standing abdominal pain and nausea, whose CT revealed the presence of a large mesenteric mass. A biopsy was performed, revealing benign chronic inflammation, fibrosis and IgG4-positive plasmocytes consistent with sclerosing mesenteritis. Clinical remission was achieved with corticosteroids and follow-up CTs at six and twelve months documented stability of the lesion. Furthermore, we review the current literature on the diagnosis and treatment options for this rare disease.
[Mh] Términos MeSH primario: Dolor Abdominal/etiología
Mesenterio/patología
Paniculitis Peritoneal/diagnóstico
[Mh] Términos MeSH secundario: Corticoesteroides/uso terapéutico
Biopsia
Estudios de Seguimiento
Seres Humanos
Masculino
Mesenterio/diagnóstico por imagen
Mediana Edad
Paniculitis Peritoneal/tratamiento farmacológico
Paniculitis Peritoneal/patología
Pronóstico
Tomografía Computarizada por Rayos X
[Pt] Tipo de publicación:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Adrenal Cortex Hormones)
[Em] Mes de ingreso:1710
[Cu] Fecha actualización por clase:171030
[Lr] Fecha última revisión:171030
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:171006
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.228.11542


  8 / 2735 MEDLINE  
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[PMID]:28756227
[Au] Autor:Cai J; Li B; Liu K; Feng J; Gao K; Lu F
[Ad] Dirección:Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guang Zhou, Guang Dong, PR China.
[Ti] Título:Low-dose G-CSF improves fat graft retention by mobilizing endogenous stem cells and inducing angiogenesis, whereas high-dose G-CSF inhibits adipogenesis with prolonged inflammation and severe fibrosis.
[So] Fuente:Biochem Biophys Res Commun;491(3):662-667, 2017 Sep 23.
[Is] ISSN:1090-2104
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:BACKGROUND: Hematopoietic stem cells (HSCs) promote fat graft survival by modulating its revascularization. The authors hypothesize that mobilization of HSCs by G-CSF will improve fat graft survival. Hence, we evaluated the effect of different doses of G-CSF on fat grafting. METHODS: Male 8-week-old C57 mice received high-dose G-CSF (100 µg/kg), low-dose G-CSF (10 µg/kg), and PBS (control) intraperitoneally for 7 consecutive days right after autologous fat grafting. Grafted fat was harvested at 1, 4, and 12 weeks for examination. RESULTS: The low-dose G-CSF, high-dose G-CSF, and control groups had retention rates of 73.6% ± 3.1%, 51.6% ± 4.4%, and 44.5% ± 4.0%, respectively, at 12 weeks (low-dose G-CSF versus control and low-dose G-CSF versus high-dose G-CSF, both p < 0.05; no significant difference between high-dose G-CSF and control group). Both doses of G-CSF successfully mobilized HSCs into circulation and upregulated the level of blood-derived stem cells in fat grafts, contributing to improved angiogenesis. However, high-dose G-CSF caused a prolonged macrophage infiltration and elevated level of inflammation (IL-6 and TNF-α), which led to severe fibrosis and impaired adipogenesis (downregulated expression of PPAR-γ and CEBP-α). CONCLUSIONS: Low-dose G-CSF treatment successfully improved fat graft survival by mobilizing HSCs and inducing angiogenesis. However, high-dose G-CSF prolonged inflammation and caused severe fibrosis, leading to impaired adipogenesis and poor fat graft survival.
[Mh] Términos MeSH primario: Tejido Adiposo/inmunología
Tejido Adiposo/trasplante
Supervivencia de Injerto/efectos de los fármacos
Factor Estimulante de Colonias de Granulocitos/administración & dosificación
Neovascularización Fisiológica/efectos de los fármacos
Paniculitis/inducido químicamente
Células Madre/efectos de los fármacos
[Mh] Términos MeSH secundario: Tejido Adiposo/efectos de los fármacos
Animales
Relación Dosis-Respuesta a Droga
Fibrosis
Supervivencia de Injerto/inmunología
Factor Estimulante de Colonias de Granulocitos/efectos adversos
Masculino
Ratones
Ratones Consanguíneos C57BL
Neovascularización Fisiológica/inmunología
Paniculitis/inmunología
Paniculitis/patología
Células Madre/patología
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
143011-72-7 (Granulocyte Colony-Stimulating Factor)
[Em] Mes de ingreso:1709
[Cu] Fecha actualización por clase:170911
[Lr] Fecha última revisión:170911
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170731
[St] Status:MEDLINE


  9 / 2735 MEDLINE  
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[PMID]:28737201
[Au] Autor:Puchi Silva A; López Radrigán P; Zapico Lafuente M; Tapia Carrere S; González Bombardiere S
[Ad] Dirección:Escuela de Medicina, Facultad de Medicina, Universidad Andres Bello, Viña del Mar, Chile.
[Ti] Título:[Paniculitis as manifestation of prolonged febrile syndrome: Case report].
[Ti] Título:Paniculitis como manifestación de síndrome febril prolongado en pediatría: Caso clínico..
[So] Fuente:Rev Chil Pediatr;88(3):398-403, 2017 Jun.
[Is] ISSN:0717-6228
[Cp] País de publicación:Chile
[La] Idioma:spa
[Ab] Resumen:Fever of unknown origin (FUO) is defined as fever over 7 to 10 days without a diagnosis despite a complete initial study. The most frequent causes are infections, autoimmune and tumors. Even though most cases are self-limited there is a minority that has an underlying etiology with an ominous forecast, encouraging a systematized study. OBJECTIVE: To report a rare case of a boy who presented fever of unknown origin associated to panniculitis and was diagnosed of subcutaneous panniculitis-like-T cell lymphoma and to emphasis the importance of a sequential study of FUO, in order to reach a diagnosis in patients who need a timely intervention. CLINICAL CASE: A ten year old boy, previously healthy, presented subcutaneous nodular lesions of 2 month of evolution, located in abdominal region and extremities, given few symptoms, associated with prolonged fever. He was hospitalized for proper study, in first instance infectious and immune causes were discarded and through lesions biopsy the diagnose of subcutaneous panniculitis-like-T cell lymphoma was reached. CONCLUSION: When FUO is diagnosed, most prevalent causes must be discarded. Then, differential diagnosis, such as immune and neoplasic etiologies, have to be considered. If FUO is associated to elemental nodular lesions, biopsy must be indicated early, in order to find potential malignant cases, avoiding therapeutic delay.
[Pt] Tipo de publicación:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mes de ingreso:1707
[Cu] Fecha actualización por clase:170724
[Lr] Fecha última revisión:170724
[St] Status:In-Process


  10 / 2735 MEDLINE  
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[PMID]:28712750
[Au] Autor:Khasminsky V; Ram E; Atar E; Steinminz A; Issa N; Bachar GN
[Ad] Dirección:Department of Diagnostic Imaging, Rabin Medical Center, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
[Ti] Título:Is there an association between mesenteric panniculitis and lymphoma? A case control analysis.
[So] Fuente:Clin Radiol;72(10):844-849, 2017 Oct.
[Is] ISSN:1365-229X
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:AIM: To determine the prevalence and association of mesenteric panniculitis (MP) in a group of patients with non-Hodgkin's lymphoma (NHL) compared to control group. MATERIALS AND METHODS: We retrospectively evaluated computed tomography (CT) and combined positron-emission tomography (PET) with CT examinations of a total of 166 patients who were diagnosed with NHL over a period of 5 years (2008-2013). The control group consisted of 332 subjects who were matched for gender and age at the time period the examinations were performed on the study group. A combination of radiological signs and absence of 2-[ F]-fluoro-2-deoxy-d-glucose (FDG)-uptake was used to establish the diagnosis of MP and distinguish it from the involvement of mesentery by lymphoma. RESULTS: MP was identified in three patients (prevalence 1.8%) from the study group as compared to seven subjects out of 332 (2.1%) in the control group (p=0.556). During the course of follow-up no changes in the imaging features of MP were seen in either group. Additionally, 27 (16.2%) patients from the study group were found to have changes in the mesentery, which were attributed to the involvement of the mesentery in the primary disease. CONCLUSION: The prevalence of MP among patients with NHL was found to be 1.8%, which corresponds to the range of its prevalence in the general population. This is contrary to the proposition that MP is associated with NHL.
[Mh] Términos MeSH primario: Linfoma no Hodgkin/diagnóstico por imagen
Paniculitis Peritoneal/diagnóstico por imagen
Tomografía Computarizada por Tomografía de Emisión de Positrones
[Mh] Términos MeSH secundario: Adulto
Anciano
Anciano de 80 o más Años
Estudios de Casos y Controles
Femenino
Seres Humanos
Masculino
Mesenterio/diagnóstico por imagen
Mediana Edad
Estudios Retrospectivos
Tomografía Computarizada por Rayos X
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1709
[Cu] Fecha actualización por clase:170913
[Lr] Fecha última revisión:170913
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:170718
[St] Status:MEDLINE



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