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  1 / 273747 MEDLINE  
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[PMID]:25038356
[Au] Autor:MacPherson P; Lalloo DG; Webb EL; Maheswaran H; Choko AT; Makombe SD; Butterworth AE; van Oosterhout JJ; Desmond N; Thindwa D; Squire SB; Hayes RJ; Corbett EL
[Ad] Dirección:Department of Clinical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom2TB and HIV Group, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi....
[Ti] Título:Effect of optional home initiation of HIV care following HIV self-testing on antiretroviral therapy initiation among adults in Malawi: a randomized clinical trial.
[So] Fuente:JAMA;312(4):372-9, 2014 Jul 23-30.
[Is] ISSN:1538-3598
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:IMPORTANCE: Self-testing for HIV infection may contribute to early diagnosis of HIV, but without necessarily increasing antiretroviral therapy (ART) initiation. OBJECTIVE: To investigate whether offering optional home initiation of HIV care after HIV self-testing might increase demand for ART initiation, compared with HIV self-testing accompanied by facility-based services only. DESIGN, SETTING, AND PARTICIPANTS: Cluster randomized trial conducted in Blantyre, Malawi, between January 30 and November 5, 2012, using restricted 1:1 randomization of 14 community health worker catchment areas. Participants were all adult (≥16 years) residents (n = 16,660) who received access to home HIV self-testing through resident volunteers. This was a second-stage randomization of clusters allocated to the HIV self-testing group of a parent trial. INTERVENTIONS: Clusters were randomly allocated to facility-based care or optional home initiation of HIV care (including 2 weeks of ART if eligible) for participants reporting positive HIV self-test results. MAIN OUTCOMES AND MEASURES: The preplanned primary outcome compared between groups the proportion of all adult residents who initiated ART within the first 6 months of HIV self-testing availability. Secondary outcomes were uptake of HIV self-testing, reporting of positive HIV self-test results, and rates of loss from ART at 6 months. RESULTS: A significantly greater proportion of adults in the home group initiated ART (181/8194, 2.2%) compared with the facility group (63/8466, 0.7%; risk ratio [RR], 2.94, 95% CI, 2.10-4.12; P < .001). Uptake of HIV self-testing was high in both the home (5287/8194, 64.9%) and facility groups (4433/8466, 52.7%; RR, 1.23; 95% CI, 0.96-1.58; P = .10). Significantly more adults reported positive HIV self-test results in the home group (490/8194 [6.0%] vs the facility group, 278/8466 [3.3%]; RR, 1.86; 95% CI, 1.16-2.97; P = .006). After 6 months, 52 of 181 ART initiators (28.7%) and 15 of 63 ART initiators (23.8%) in the home and facility groups, respectively, were lost from ART (adjusted incidence rate ratio, 1.18; 95% CI, 0.62-2.25, P = .57). CONCLUSIONS AND RELEVANCE: Among Malawian adults offered HIV self-testing, optional home initiation of care compared with standard HIV care resulted in a significant increase in the proportion of adults initiating ART. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01414413.
[Mh] Términos MeSH primario: Antirretrovirales/administración & dosificación
Infecciones por VIH/diagnóstico
Infecciones por VIH/quimioterapia
Servicios de Atención de Salud a Domicilio
[Mh] Términos MeSH secundario: Adolescente
Adulto
Femenino
Seropositividad para VIH
Humanos
Malaui
Masculino
Tamizaje Masivo
Mediana Edad
Cooperación del Paciente
Autocuidado
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nombre de substancia:
0 (Anti-Retroviral Agents)
[Em] Mes de ingreso:1408
[Cu] Fecha actualización por clase:140804
[Lr] Fecha última revisión:140804
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:140720
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2014.6493


  2 / 273747 MEDLINE  
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[PMID]:24642579
[Au] Autor:Price JC; Seaberg EC; Latanich R; Budoff MJ; Kingsley LA; Palella FJ; Witt MD; Post WS; Thio CL
[Ad] Dirección:Division of Gastroenterology and Hepatology, Department of Medicine, University of California San Francisco, San Francisco, California, USA....
[Ti] Título:Risk factors for fatty liver in the Multicenter AIDS Cohort Study.
[So] Fuente:Am J Gastroenterol;109(5):695-704, 2014 May.
[Is] ISSN:1572-0241
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:OBJECTIVES: Human immunodeficiency virus (HIV) infection and antiretroviral therapy (ART) may increase the risk of fatty liver disease. We determined the prevalence of and risk factors for fatty liver by comparing HIV-infected men with HIV-uninfected men who have sex with men in the Multicenter AIDS Cohort Study (MACS). METHODS: In 719 MACS participants who consumed less than three alcoholic drinks daily, fatty liver was defined as a liver-to-spleen attenuation ratio <1 on noncontrast computed tomography (CT). We genotyped single nucleotide polymorphisms in the patatin-like phospholipase domain-containing 3 (PNPLA3) gene and in other genes previously associated with nonalcoholic fatty liver disease. Risk factors for fatty liver were determined using multivariable logistic regression. RESULTS: Among 254 HIV-uninfected men and 465 HIV-infected men, 56% were White with median age 53 years and median body mass index 25.8 kg/m(2). The vast majority of HIV-infected men (92%) were on ART, and 87% of the HIV-infected men were treated with a nucleoside reverse transcriptase inhibitor for a median duration of 8.5 years. Overall, 15% of the cohort had fatty liver, which was more common in the HIV-uninfected compared with the HIV-infected men (19 vs. 13%, P=0.02). In multivariable analysis, HIV infection was associated with a lower prevalence of fatty liver (odds ratio (OR)=0.44, P=0.002), whereas a higher prevalence of fatty liver was seen in participants with PNPLA3 (rs738409) non-CC genotype (OR=2.06, P=0.005), more abdominal visceral adipose tissue (OR=1.08 per 10 cm(2), P<0.001), and homeostatic model assessment of insulin resistance (HOMA-IR) ≥4.9 (OR=2.50, P=0.001). Among HIV-infected men, PNPLA3 (rs738409) non-CC genotype was associated with a higher prevalence of fatty liver (OR=3.30, P=0.001) and cumulative dideoxynucleoside exposure (OR=1.44 per 5 years, P=0.02). CONCLUSIONS: CT-defined fatty liver is common among men at risk for HIV infection and is associated with greater visceral adiposity, HOMA-IR, and PNPLA3 (rs738409). Although treated HIV infection was associated with a lower prevalence of fatty liver, prolonged exposure to dideoxynucleoside analogs is associated with higher prevalence.
[Mh] Términos MeSH primario: Hígado Graso/etiología
Infecciones por VIH/complicaciones
[Mh] Términos MeSH secundario: Fármacos Anti-VIH/efectos adversos
Fármacos Anti-VIH/uso terapéutico
Estudios de Casos y Controles
Estudios de Cohortes
Estudios Transversales
Hígado Graso/epidemiología
Marcadores Genéticos
Predisposición Genética a la Enfermedad
Genotipo
Homosexualidad Masculina
Humanos
Resistencia a la Insulina
Lipasa/genética
Modelos Logísticos
Masculino
Proteínas de la Membrana/genética
Mediana Edad
Análisis Multivariante
Obesidad Abdominal/complicaciones
Prevalencia
Estudios Prospectivos
Factores de Riesgo
[Pt] Tipo de publicación:JOURNAL ARTICLE; MULTICENTER STUDY; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nombre de substancia:
0 (Anti-HIV Agents); 0 (Genetic Markers); 0 (Membrane Proteins); EC 3.1.1.3 (Lipase); EC 3.1.1.3 (adiponutrin, human)
[Em] Mes de ingreso:1406
[Cu] Fecha actualización por clase:140804
[Lr] Fecha última revisión:140804
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:140506
[St] Status:MEDLINE
[do] DOI:10.1038/ajg.2014.32


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[PMID]:24493261
[Au] Autor:Agwu AL; Neptune A; Voss C; Yehia B; Rutstein R; HIV Research Network
[Ad] Dirección:Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland2Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland....
[Ti] Título:CD4 counts of nonperinatally HIV-infected youth and young adults presenting for HIV care between 2002 and 2010.
[So] Fuente:JAMA Pediatr;168(4):381-3, 2014 Apr.
[Is] ISSN:2168-6211
[Cp] País de publicación:United States
[La] Idioma:eng
[Mh] Términos MeSH primario: Recuento de Linfocito CD4
Linfocitos T CD4-Positivos/inmunología
Infecciones por VIH/inmunología
[Mh] Términos MeSH secundario: Adolescente
Niño
Femenino
Humanos
Modelos Logísticos
Masculino
Estudios Retrospectivos
Estados Unidos
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Em] Mes de ingreso:1405
[Cu] Fecha actualización por clase:140804
[Lr] Fecha última revisión:140804
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:140408
[St] Status:MEDLINE
[do] DOI:10.1001/jamapediatrics.2013.4531


  4 / 273747 MEDLINE  
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[PMID]:24506064
[Au] Autor:Kovalskyy DB; Ivanov DN
[Ad] Dirección:Department of Biochemistry and Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio , 7703 Floyd Curl Drive, San Antonio, Texas 78229, United States.
[Ti] Título:Recognition of the HIV capsid by the TRIM5α restriction factor is mediated by a subset of pre-existing conformations of the TRIM5α SPRY domain.
[So] Fuente:Biochemistry;53(9):1466-76, 2014 Mar 11.
[Is] ISSN:1520-4995
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:The binding of the TRIM5α restriction factor to the HIV capsid is mediated by the C-terminal SPRY domain of TRIM5α. Atomic-level details of this host-pathogen interaction, which involves mobile variable loops of the SPRY domain, remain unclear. Some of the key determinants of restriction are encompassed by the long and disordered v1 loop of the SPRY domain. We applied molecular modeling to elucidate the conformational repertoire of the v1 loop and its role in the interaction with the capsid. All-atom replica exchange molecular dynamics revealed multiple transient, interconverting states of the v1 loop consistent with the intrinsic disorder observed experimentally. The docking of the SPRY conformations representing 10 most populated states onto the high-resolution model of the assembled HIV-1 capsid revealed that a subset of v1 conformations produced plausible binding poses, in which the SPRY domain binds close to the pseudo-2-fold symmetry axis and the v1 loop spans the interhexamer gap. Such binding mode is well supported by the NMR binding data and known escape mutants. We speculate that the binding mode that involves interaction of the capsid with a subset of preexisting SPRY conformations arising from the intrinsic disorder of the v1 loop may explain the remarkable ability of TRIM5α to resist viral evasion by mutagenesis and to restrict divergent retroviruses.
[Mh] Términos MeSH primario: Cápsida/metabolismo
Proteínas Portadoras/química
Proteínas Portadoras/metabolismo
VIH-1/metabolismo
[Mh] Términos MeSH secundario: Proteínas del Cápside/química
Proteínas del Cápside/metabolismo
Humanos
Simulación del Acoplamiento Molecular
Unión Proteica
Estructura Secundaria de Proteína
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Capsid Proteins); 0 (Carrier Proteins); 0 (TRIM5 protein, human)
[Em] Mes de ingreso:1405
[Cu] Fecha actualización por clase:140804
[Lr] Fecha última revisión:140804
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:140311
[St] Status:MEDLINE
[do] DOI:10.1021/bi4014962


  5 / 273747 MEDLINE  
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[PMID]:24581056
[Au] Autor:Frye V; Egan JE; Van Tieu H; Cerdá M; Ompad D; Koblin BA
[Ad] Dirección:Lindsley F. Kimball Research Institute, United States; Columbia University, United States. Electronic address: vfrye@nybloodcenter.org....
[Ti] Título:"I didn't think I could get out of the fucking park." Gay men's retrospective accounts of neighborhood space, emerging sexuality and migrations.
[So] Fuente:Soc Sci Med;104:6-14, 2014 Mar.
[Is] ISSN:1873-5347
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Young, African American and Latino gay, bisexual and other men who have sex with men (MSM) are disproportionately represented among new HIV cases according to the most recent national surveillance statistics. Analysts have noted that these racial/ethnic disparities in HIV among MSM exist within the wider context of sexual, mental and physical health disparities between MSM and heterosexuals. The intercorrelation of these adverse health outcomes among MSM, termed syndemics, has been theorized to be socially produced by a heterosexist social system that marginalizes lesbian, gay, bisexual, MSM and other sexual minorities. African American and Latino MSM experience overlapping systems of oppression that may increase their risk of experiencing syndemic health outcomes. In this paper, using data from twenty in-depth qualitative interviews with MSM living in four New York City (NYC) neighborhoods, we present accounts of neighborhood space, examining how space can both physically constitute and reinforce social systems of stratification and oppression, which in turn produce social disparities in sexual health outcomes. By analyzing accounts of emerging sexuality in neighborhood space, i.e. across time and space, we identify pathways to risk and contribute to our understanding of how neighborhood space is experienced by gay men, adding to our ability to support young men as they emerge in place and to shape the social topography of urban areas.
[Mh] Términos MeSH primario: Homosexualidad Masculina/psicología
Distribución Espacial de la Población
Sexualidad/psicología
Migrantes/psicología
[Mh] Términos MeSH secundario: Adulto
Afroamericanos/psicología
Afroamericanos/estadística & datos numéricos
Infecciones por VIH/etnología
Disparidades en el Estado de Salud
Hispanoamericanos/psicología
Hispanoamericanos/estadística & datos numéricos
Homosexualidad Masculina/etnología
Humanos
Masculino
Ciudad de Nueva York
Investigación Cualitativa
Estudios Retrospectivos
Factores de Riesgo
Sexualidad/etnología
Determinantes Sociales de la Salud/etnología
Análisis Espacial
Migrantes/estadística & datos numéricos
Población Urbana
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mes de ingreso:1408
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:140303
[St] Status:MEDLINE


  6 / 273747 MEDLINE  
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[PMID]:24434556
[Au] Autor:De D; Jeong MH; Leem YE; Svergun DI; Wemmer DE; Kang JS; Kim KK; Kim SH
[Ad] Dirección:Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 440-746, Korea.
[Ti] Título:Inhibition of master transcription factors in pluripotent cells induces early stage differentiation.
[So] Fuente:Proc Natl Acad Sci U S A;111(5):1778-83, 2014 Feb 4.
[Is] ISSN:1091-6490
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:The potential for pluripotent cells to differentiate into diverse specialized cell types has given much hope to the field of regenerative medicine. Nevertheless, the low efficiency of cell commitment has been a major bottleneck in this field. Here we provide a strategy to enhance the efficiency of early differentiation of pluripotent cells. We hypothesized that the initial phase of differentiation can be enhanced if the transcriptional activity of master regulators of stemness is suppressed, blocking the formation of functional transcriptomes. However, an obstacle is the lack of an efficient strategy to block protein-protein interactions. In this work, we take advantage of the biochemical property of seventeen kilodalton protein (Skp), a bacterial molecular chaperone that binds directly to sex determining region Y-box 2 (Sox2). The small angle X-ray scattering analyses provided a low resolution model of the complex and suggested that the transactivation domain of Sox2 is probably wrapped in a cleft on Skp trimer. Upon the transduction of Skp into pluripotent cells, the transcriptional activity of Sox2 was inhibited and the expression of Sox2 and octamer-binding transcription factor 4 was reduced, which resulted in the expression of early differentiation markers and appearance of early neuronal and cardiac progenitors. These results suggest that the initial stage of differentiation can be accelerated by inhibiting master transcription factors of stemness. This strategy can possibly be applied to increase the efficiency of stem cell differentiation into various cell types and also provides a clue to understanding the mechanism of early differentiation.
[Mh] Términos MeSH primario: Diferenciación Celular
Células Madre Pluripotentes/citología
Células Madre Pluripotentes/metabolismo
Factores de Transcripción/metabolismo
[Mh] Términos MeSH secundario: Animales
Proteínas de Escherichia coli/metabolismo
Ratones
Modelos Biológicos
Modelos Moleculares
Factores de Transcripción SOXB1/metabolismo
Dispersión del Ángulo Pequeño
Soluciones
Transducción Genética
Difracción de Rayos X
Productos del Gen tat del Virus de la Inmunodeficiencia Humana/metabolismo
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nombre de substancia:
0 (Escherichia coli Proteins); 0 (SOXB1 Transcription Factors); 0 (Solutions); 0 (Transcription Factors); 0 (tat Gene Products, Human Immunodeficiency Virus)
[Em] Mes de ingreso:1404
[Cu] Fecha actualización por clase:140804
[Lr] Fecha última revisión:140804
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:140205
[St] Status:MEDLINE
[do] DOI:10.1073/pnas.1323386111


  7 / 273747 MEDLINE  
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[PMID]:24078559
[Au] Autor:Tan IL; Smith BR; Hammond E; Vornbrock-Roosa H; Creighton J; Selnes O; McArthur JC; Sacktor N
[Ti] Título:Older individuals with HIV infection have greater memory deficits than younger individuals.
[So] Fuente:J Neurovirol;19(6):531-6, 2013 Dec.
[Is] ISSN:1538-2443
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:The prevalence of HIV-associated neurocognitive disorder (HAND) remains persistently high in the era of combination antiretroviral therapy. We aimed to characterize the pattern of neurocognitive dysfunction in older subjects with HAND in particular amnestic versus non-amnestic impairment. One hundred six subjects from the Johns Hopkins University NIMH Clinical Outcomes cohort underwent standardized neuropsychological (NP) testing between November 2006 and June 2010. We examined performance in seven cognitive domains (memory, attention, speed of processing,visuospatial, language, motor, and executive). Older subjects were defined as age >50 years at the time of NP testing.Subjects were diagnosed with HAND according to established criteria and dichotomized into amnestic cognitive impairment or non-amnestic cognitive impairment with deficit defined as z scores <−1.5 for the verbal and nonverbal memory domains.There were 32 older subjects with a mean age (SD) of 54.2 (2.8) years and 74 younger subjects, 43.7 (4.3) years. Older age was associated with a 4.8-fold higher odds of memory deficits adjusted for potential confounders (p =0.035) identified a priori. With age modeled as a continuous covariate,every 1 year increase in age was associated with a 1.11-fold higher odds of memory deficit (p =0.05). There was a higher proportion of amnestic cognitive impairment among older subjects than younger subjects with HIV infection. Neurodegenerative processes other than those directly due to HIV maybe increasingly important as individuals with chronic HIV infection and HAND survive into older age.
[Mh] Términos MeSH primario: Amnesia/psicología
Fármacos Anti-VIH/uso terapéutico
Trastornos del Conocimiento/psicología
Infecciones por VIH/quimioterapia
VIH-1
[Mh] Términos MeSH secundario: Adulto
Factores de Edad
Amnesia/etiología
Amnesia/virología
Atención
Cognición
Trastornos del Conocimiento/etiología
Trastornos del Conocimiento/virología
Función Ejecutiva
Femenino
Infecciones por VIH/complicaciones
Infecciones por VIH/psicología
Humanos
Masculino
Memoria
Mediana Edad
Actividad Motora
Pruebas Neuropsicológicas
Índice de Severidad de la Enfermedad
Habla
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Anti-HIV Agents)
[Em] Mes de ingreso:1408
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:140130
[St] Status:MEDLINE


  8 / 273747 MEDLINE  
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[PMID]:24291199
[Au] Autor:Figueiredo S; Charmeteau B; Surenaud M; Salmon D; Launay O; Guillet JG; Hosmalin A; Gahery H
[Ad] Dirección:Inserm U1016, Institut Cochin, Paris, France; CNRS UMR8104, Paris, France; Univ Paris Descartes, Paris, France....
[Ti] Título:Memory CD8(+) T cells elicited by HIV-1 lipopeptide vaccines display similar phenotypic profiles but differences in term of magnitude and multifunctionality compared with FLU- or EBV-specific memory T cells in humans.
[So] Fuente:Vaccine;32(4):492-501, 2014 Jan 16.
[Is] ISSN:1873-2518
[Cp] País de publicación:Netherlands
[La] Idioma:eng
[Ab] Resumen:Differentiation marker, multifunctionality and magnitude analyses of specific-CD8(+) memory T cells are crucial to improve development of HIV vaccines designed to generate cell-mediated immunity. Therefore, we fully characterized the HIV-specific CD8(+) T cell responses induced in volunteers vaccinated with HIV lipopeptide vaccines for phenotypic markers, tetramer staining, cytokine secretion, and cytotoxic activities. The frequency of ex vivo CD8(+) T cells elicited by lipopeptide vaccines is very rare and central-memory phenotype and functions of these cells were been shown to be important in AIDS immunity. So, we expanded them using specific peptides to compare the memory T cell responses induced in volunteers by HIV vaccines with responses to influenza (FLU) or Epstein Barr virus (EBV). By analyzing the differentiation state of IFN-γ-secreting CD8(+) T cells, we found a CCR7(-)CD45RA(-)CD28(+int)/CD28(-) profile (>85%) belonging to a subset of intermediate-differentiated effector T cells for HIV, FLU, and EBV. We then assessed the quality of the response by measuring various T cell functions. The percentage of single IFN-γ T cell producers in response to HIV was 62% of the total of secreting T cells compared with 35% for FLU and EBV, dual and triple (IFN-γ/IL-2/CD107a) T cell producers could also be detected but at lower levels (8% compared with 37%). Finally, HIV-specific T cells secreted IFN-γ and TNF-α, but not the dual combination like FLU- and EBV-specific T cells. Thus, we found that the functional profile and magnitude of expanded HIV-specific CD8(+) T precursors were more limited than those of to FLU- and EBV-specific CD8(+) T cells. These data show that CD8(+) T cells induced by these HIV vaccines have a similar differentiation profile to FLU and EBV CD8(+) T cells, but that the vaccine potency to induce multifunctional T cells needs to be increased in order to improve vaccination strategies.
[Mh] Términos MeSH primario: Vacunas contra el SIDA/inmunología
Linfocitos T CD8-positivos/inmunología
Infecciones por VIH/prevención & control
Memoria Inmunológica
Activación de Linfocitos
[Mh] Términos MeSH secundario: Infecciones por Virus de Epstein-Barr/inmunología
VIH-1
Voluntarios Sanos
Humanos
Inmunidad Celular
Gripe Humana/inmunología
Interferón gamma/inmunología
Lipopéptidos
[Pt] Tipo de publicación:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nombre de substancia:
0 (AIDS Vaccines); 0 (Lipopeptides); 82115-62-6 (Interferon-gamma)
[Em] Mes de ingreso:1408
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:140109
[St] Status:MEDLINE


  9 / 273747 MEDLINE  
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[PMID]:24280279
[Au] Autor:Pissani F; Malherbe DC; Schuman JT; Robins H; Park BS; Krebs SJ; Barnett SW; Haigwood NL
[Ad] Dirección:Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97217, United States; The Vaccine and Gene Therapy Institute, Beaverton, OR 97006, United States; Oregon National Primate Research Center, Beaverton, OR 97006, United States....
[Ti] Título:Improvement of antibody responses by HIV envelope DNA and protein co-immunization.
[So] Fuente:Vaccine;32(4):507-13, 2014 Jan 16.
[Is] ISSN:1873-2518
[Cp] País de publicación:Netherlands
[La] Idioma:eng
[Ab] Resumen:BACKGROUND: Developing HIV envelope (Env) vaccine components that elicit durable and protective antibody responses is an urgent priority, given the results from the RV144 trial. Optimization of both the immunogens and vaccination strategies will be needed to generate potent, durable antibodies. Due to the diversity of HIV, an effective Env-based vaccine will most likely require an extensive coverage of antigenic variants. A vaccine co-delivering Env immunogens as DNA and protein components could provide such coverage. Here, we examine a DNA and protein co-immunization strategy by characterizing the antibody responses and evaluating the relative contribution of each vaccine component. METHOD: We co-immunized rabbits with representative subtype A or B HIV gp160 plasmid DNA plus Env gp140 trimeric glycoprotein and compared the responses to those obtained with either glycoprotein alone or glycoprotein in combination with empty vector. RESULTS: DNA and glycoprotein co-immunization was superior to immunization with glycoprotein alone by enhancing antibody kinetics, magnitude, avidity, and neutralizing potency. Importantly, the empty DNA vector did not contribute to these responses. Humoral responses elicited by mismatched DNA and protein components were comparable or higher than the responses produced by the matched vaccines. CONCLUSION: Our data show that co-delivering DNA and protein can augment antibodies to Env. The rate and magnitude of immune responses suggest that this approach has the potential to streamline vaccine regimens by inducing higher antibody responses using fewer vaccinations, an advantage for a successful HIV vaccine design.
[Mh] Términos MeSH primario: Vacunas contra el SIDA/inmunología
Formación de Anticuerpos
Proteínas gp160 de Envoltorio del VIH/inmunología
Infecciones por VIH/prevención & control
Productos del Gen env del Virus de la Inmunodeficiencia Humana/inmunología
[Mh] Términos MeSH secundario: Animales
Anticuerpos Neutralizantes/sangre
Afinidad de Anticuerpos
ADN Viral/inmunología
Femenino
Anticuerpos Anti-VIH/sangre
Conejos
Vacunas de ADN/inmunología
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nombre de substancia:
0 (AIDS Vaccines); 0 (Antibodies, Neutralizing); 0 (DNA, Viral); 0 (HIV Antibodies); 0 (HIV Envelope Protein gp160); 0 (Vaccines, DNA); 0 (env Gene Products, Human Immunodeficiency Virus); 0 (gp140 envelope protein, Human immunodeficiency virus 1)
[Em] Mes de ingreso:1408
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:140109
[St] Status:MEDLINE


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[PMID]:24347455
[Au] Autor:Davidson DJ; Shaukat YM; Jenabzadeh R; Gupte CM
[Ad] Dirección:Department of T&O, Imperial College Healthcare NHS Trust, London, UK.
[Ti] Título:Spontaneous bilateral compartment syndrome in a HIV-positive patient.
[So] Fuente:BMJ Case Rep;2013, 2013.
[Is] ISSN:1757-790X
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Spontaneous bilateral compartment syndrome is a very rare condition but one which requires swift diagnosis and urgent surgical decompression by fasciotomies in order to achieve the best outcome. We present the case of a 31-year-old HIV-positive man. The case highlights the perils of being sidetracked by an atypical clinical history instead of acting on the classical clinical examination findings. We will discuss the presentation and management of this patient, review the literature and highlight the key learning points. The most important learning point being that no matter how atypical the history, if a patient presents with limb pain out of proportion to the injury (with or without pain on passive stretch), sensory changes and a loss of motor power, then a diagnosis of acute compartment syndrome must be considered.
[Mh] Términos MeSH primario: Síndromes Compartimentales/diagnóstico
Fascia/patología
Infecciones por VIH/complicaciones
Pierna/patología
Músculo Esquelético/patología
[Mh] Términos MeSH secundario: Adulto
Síndromes Compartimentales/complicaciones
Síndromes Compartimentales/cirugía
Descompresión Quirúrgica
Fascia/cirugía
Humanos
Pierna/cirugía
Masculino
Músculo Esquelético/cirugía
[Pt] Tipo de publicación:CASE REPORTS; JOURNAL ARTICLE
[Em] Mes de ingreso:1408
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:131218
[St] Status:MEDLINE



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