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  1 / 280460 MEDLINE  
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[PMID]:25436820
[Au] Autor:Matthews LT; Milford C; Kaida A; Ehrlich MJ; Ng C; Greener R; Mosery FN; Harrison A; Psaros C; Safren SA; Bajunirwe F; Wilson IB; Bangsberg DR; Smit JA
[Ad] Dirección:*Center for Global Health and Division of Infectious Disease, Massachusetts General Hospital, Boston, MA; †MatCH Research (Maternal, Adolescent and Child Health Research), Department of Obstetrics and Gynaecology, Faculty of Health Sciences, University of the Witwatersrand, Durban, South Africa; ‡Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; §Department of Psychiatry, Cambridge Health Alliance, Cambridge, MA; ‖Harvard Medical School, Boston, MA; ¶Department of Behavioral and Social Sciences, School of Public Health, Brown University, Providence, RI; #Department of Psychiatry, Massachusetts General Hospital, Boston, MA; **Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda; ††Department of Health Services, Policy, and Practice, School of Public Health, Brown University, Providence, RI; and ‡‡School of Pharmacy and Pharmacology, Faculty of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
[Ti] Título:Lost opportunities to reduce periconception HIV transmission: safer conception counseling by South African providers addresses perinatal but not sexual HIV transmission.
[So] Fuente:J Acquir Immune Defic Syndr;67 Suppl 4:S210-7, 2014 Dec 1.
[Is] ISSN:1944-7884
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:INTRODUCTION: Safer conception strategies create opportunities for HIV-serodiscordant couples to realize fertility goals and minimize periconception HIV transmission. Patient-provider communication about fertility goals is the first step in safer conception counseling. METHODS: We explored provider practices of assessing fertility intentions among HIV-infected men and women, attitudes toward people living with HIV (PLWH) having children, and knowledge and provision of safer conception advice. We conducted in-depth interviews (9 counselors, 15 nurses, 5 doctors) and focus group discussions (6 counselors, 7 professional nurses) in eThekwini District, South Africa. Data were translated, transcribed, and analyzed using content analysis with NVivo10 software. RESULTS: Among 42 participants, median age was 41 (range, 28-60) years, 93% (39) were women, and median years worked in the clinic was 7 (range, 1-27). Some providers assessed women's, not men's, plans for having children at antiretroviral therapy initiation, to avoid fetal exposure to efavirenz. When conducted, reproductive counseling included CD4 cell count and HIV viral load assessment, advising mutual HIV status disclosure, and referral to another provider. Barriers to safer conception counseling included provider assumptions of HIV seroconcordance, low knowledge of safer conception strategies, personal feelings toward PLWH having children, and challenges to tailoring safer sex messages. CONCLUSIONS: Providers need information about HIV serodiscordance and safer conception strategies to move beyond discussing only perinatal transmission and maternal health for PLWH who choose to conceive. Safer conception counseling may be more feasible if the message is distilled to delaying conception attempts until the infected partner is on antiretroviral therapy. Designated and motivated nurse providers may be required to provide comprehensive safer conception counseling.
[Mh] Términos MeSH primario: Fertilización
Infecciones por VIH/transmisión
Transmisión Vertical de Enfermedad Infecciosa/prevención & control
Complicaciones Infecciosas del Embarazo/prevención & control
Sexo Seguro
Consejo Sexual/métodos
Parejas Sexuales/psicología
[Mh] Términos MeSH secundario: Adulto
Grupo de Ascendencia Continental Africana
Actitud Frente a la Salud
Anticoncepción/psicología
Femenino
Grupos Focales
Infecciones por VIH/prevención & control
Infecciones por VIH/psicología
Seropositividad para VIH/transmisión
Personal de Salud
Humanos
Masculino
Mediana Edad
Embarazo
Sudáfrica
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mes de ingreso:1501
[Cu] Fecha actualización por clase:150404
[Lr] Fecha última revisión:150404
[Sb] Subgrupo de revista:IM; X
[Da] Fecha de ingreso para procesamiento:141202
[St] Status:MEDLINE
[do] DOI:10.1097/QAI.0000000000000374


  2 / 280460 MEDLINE  
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[PMID]:25402363
[Au] Autor:Archin NM; Sung JM; Garrido C; Soriano-Sarabia N; Margolis DM
[Ad] Dirección:Department of Medicine, University of North Carolina at Chapel Hill....
[Ti] Título:Eradicating HIV-1 infection: seeking to clear a persistent pathogen.
[So] Fuente:Nat Rev Microbiol;12(11):750-64, 2014 Nov.
[Is] ISSN:1740-1534
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Effective antiretroviral therapy (ART) blunts viraemia, which enables HIV-1-infected individuals to control infection and live long, productive lives. However, HIV-1 infection remains incurable owing to the persistence of a viral reservoir that harbours integrated provirus within host cellular DNA. This latent infection is unaffected by ART and hidden from the immune system. Recent studies have focused on the development of therapies to disrupt latency. These efforts unmasked residual viral genomes and highlighted the need to enable the clearance of latently infected cells, perhaps via old and new strategies that improve the HIV-1-specific immune response. In this Review, we explore new approaches to eradicate established HIV-1 infection and avoid the burden of lifelong ART.
[Mh] Términos MeSH primario: Fármacos Anti-VIH/uso terapéutico
Erradicación de la Enfermedad/métodos
Infecciones por VIH/prevención & control
VIH-1/fisiología
Latencia del Virus/fisiología
[Mh] Términos MeSH secundario: Animales
Línea Celular
Modelos Animales de Enfermedad
Infecciones por VIH/inmunología
Infecciones por VIH/terapia
Infecciones por VIH/virología
Humanos
Viremia
Integración Viral
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; REVIEW
[Nm] Nombre de substancia:
0 (Anti-HIV Agents)
[Em] Mes de ingreso:1501
[Cu] Fecha actualización por clase:150404
[Lr] Fecha última revisión:150404
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:141118
[St] Status:MEDLINE
[do] DOI:10.1038/nrmicro3352


  3 / 280460 MEDLINE  
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[PMID]:25232099
[Au] Autor:Schauer GD; Huber KD; Leuba SH; Sluis-Cremer N
[Ad] Dirección:Program in Molecular Biophysics and Structural Biology, University of Pittsburgh School of Medicine, Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA 15213, USA Department of Cell Biology, University of Pittsburgh School of Medicine, Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA...
[Ti] Título:Mechanism of allosteric inhibition of HIV-1 reverse transcriptase revealed by single-molecule and ensemble fluorescence.
[So] Fuente:Nucleic Acids Res;42(18):11687-96, 2014 Oct.
[Is] ISSN:1362-4962
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) are routinely used to treat HIV-1 infection, yet their mechanism of action remains unclear despite intensive investigation. In this study, we developed complementary single-molecule fluorescence and ensemble fluorescence anisotropy approaches to discover how NNRTIs modulate the intra-molecular conformational changes and inter-molecular dynamics of RT-template/primer (T/P) and RT-T/P-dNTP complexes. We found that NNRTI binding to RT induces opening of the fingers and thumb subdomains, which increases the dynamic sliding motion of the enzyme on the T/P and reduces dNTP binding affinity. Further, efavirenz promotes formation of the E138-K101 salt bridge between the p51 and p66 subunits of RT, which contributes to opening of the thumb/fingers subdomains. Engineering a more polar salt bridge between p51 and p66 resulted in even greater increases in the thumb/fingers opening, RT sliding, dNTP binding disruption and in vitro and in vivo RT inhibition than were observed with wild-type RT. We also observed that K103N, a clinically relevant NNRTI resistance mutation, does not prevent binding between efavirenz and RT-T/P but instead allows formation of a stable and productive RT-T/P-dNTP complex, possibly through disruption of the E138-K101 salt bridge. Collectively, these data describe unique structure-activity-resistance relationships that could be exploited for drug development.
[Mh] Términos MeSH primario: Transcriptasa Inversa del VIH/antagonistas & inhibidores
Transcriptasa Inversa del VIH/química
Inhibidores de Transcriptasa Inversa/farmacología
[Mh] Términos MeSH secundario: Regulación Alostérica
Benzoxazinas/farmacología
Cartilla de ADN
Desoxirribonucleótidos/metabolismo
Polarización de Fluorescencia
Transcriptasa Inversa del VIH/genética
Transcriptasa Inversa del VIH/metabolismo
Mutación
Subunidades de Proteína/química
Moldes Genéticos
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nombre de substancia:
0 (Benzoxazines); 0 (DNA Primers); 0 (Deoxyribonucleotides); 0 (Protein Subunits); 0 (Reverse Transcriptase Inhibitors); EC 2.7.7.- (reverse transcriptase, Human immunodeficiency virus 1); EC 2.7.7.49 (HIV Reverse Transcriptase); JE6H2O27P8 (efavirenz)
[Em] Mes de ingreso:1501
[Cu] Fecha actualización por clase:150404
[Lr] Fecha última revisión:150404
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:141010
[St] Status:MEDLINE
[do] DOI:10.1093/nar/gku819


  4 / 280460 MEDLINE  
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[PMID]:25120265
[Au] Autor:Struck D; Lawyer G; Ternes AM; Schmit JC; Bercoff DP
[Ad] Dirección:Laboratory of Retrovirology, CRP-Santé, 84, Val Fleuri, L-1526, Luxembourg daniel.struck@crp-sante.lu....
[Ti] Título:COMET: adaptive context-based modeling for ultrafast HIV-1 subtype identification.
[So] Fuente:Nucleic Acids Res;42(18):e144, 2014 Oct.
[Is] ISSN:1362-4962
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:Viral sequence classification has wide applications in clinical, epidemiological, structural and functional categorization studies. Most existing approaches rely on an initial alignment step followed by classification based on phylogenetic or statistical algorithms. Here we present an ultrafast alignment-free subtyping tool for human immunodeficiency virus type one (HIV-1) adapted from Prediction by Partial Matching compression. This tool, named COMET, was compared to the widely used phylogeny-based REGA and SCUEAL tools using synthetic and clinical HIV data sets (1,090,698 and 10,625 sequences, respectively). COMET's sensitivity and specificity were comparable to or higher than the two other subtyping tools on both data sets for known subtypes. COMET also excelled in detecting and identifying new recombinant forms, a frequent feature of the HIV epidemic. Runtime comparisons showed that COMET was almost as fast as USEARCH. This study demonstrates the advantages of alignment-free classification of viral sequences, which feature high rates of variation, recombination and insertions/deletions. COMET is free to use via an online interface.
[Mh] Términos MeSH primario: Algoritmos
VIH-1/genética
Secuenciación de Nucleótidos de Alto Rendimiento/métodos
[Mh] Términos MeSH secundario: VIH-1/clasificación
VIH-1/aislamiento & purificación
Humanos
Filogenia
Programas Informáticos
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mes de ingreso:1501
[Cu] Fecha actualización por clase:150404
[Lr] Fecha última revisión:150404
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:141010
[St] Status:MEDLINE
[do] DOI:10.1093/nar/gku739


  5 / 280460 MEDLINE  
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[PMID]:25225725
[Au] Autor:Claiborne DT; Prince JL; Hunter E
[Ad] Dirección:Emory Vaccine Center at Yerkes National Primate Research Center, Emory University.
[Ti] Título:A restriction enzyme based cloning method to assess the in vitro replication capacity of HIV-1 subtype C Gag-MJ4 chimeric viruses.
[So] Fuente:J Vis Exp;(90), 2014.
[Is] ISSN:1940-087X
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:The protective effect of many HLA class I alleles on HIV-1 pathogenesis and disease progression is, in part, attributed to their ability to target conserved portions of the HIV-1 genome that escape with difficulty. Sequence changes attributed to cellular immune pressure arise across the genome during infection, and if found within conserved regions of the genome such as Gag, can affect the ability of the virus to replicate in vitro. Transmission of HLA-linked polymorphisms in Gag to HLA-mismatched recipients has been associated with reduced set point viral loads. We hypothesized this may be due to a reduced replication capacity of the virus. Here we present a novel method for assessing the in vitro replication of HIV-1 as influenced by the gag gene isolated from acute time points from subtype C infected Zambians. This method uses restriction enzyme based cloning to insert the gag gene into a common subtype C HIV-1 proviral backbone, MJ4. This makes it more appropriate to the study of subtype C sequences than previous recombination based methods that have assessed the in vitro replication of chronically derived gag-pro sequences. Nevertheless, the protocol could be readily modified for studies of viruses from other subtypes. Moreover, this protocol details a robust and reproducible method for assessing the replication capacity of the Gag-MJ4 chimeric viruses on a CEM-based T cell line. This method was utilized for the study of Gag-MJ4 chimeric viruses derived from 149 subtype C acutely infected Zambians, and has allowed for the identification of residues in Gag that affect replication. More importantly, the implementation of this technique has facilitated a deeper understanding of how viral replication defines parameters of early HIV-1 pathogenesis such as set point viral load and longitudinal CD4+ T cell decline.
[Mh] Términos MeSH primario: Clonación Molecular/métodos
Genes gag
Infecciones por VIH/genética
Infecciones por VIH/virología
VIH-1/fisiología
Mapeo Restrictivo/métodos
Productos del Gen gag del Virus de la Inmunodeficiencia Humana/genética
[Mh] Términos MeSH secundario: Amplificación de Genes
Células HEK293
Duplicado del Terminal Largo de VIH
VIH-1/clasificación
VIH-1/genética
Humanos
Carga Viral
Replicación Viral
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; VIDEO-AUDIO MEDIA
[Nm] Nombre de substancia:
0 (gag Gene Products, Human Immunodeficiency Virus)
[Em] Mes de ingreso:1501
[Cu] Fecha actualización por clase:150404
[Lr] Fecha última revisión:150404
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:140917
[St] Status:MEDLINE
[do] DOI:10.3791/51506


  6 / 280460 MEDLINE  
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[PMID]:25038748
[Au] Autor:Uthman OA; Magidson JF; Safren SA; Nachega JB
[Ad] Dirección:Warwick-Centre for Applied Health Research and Delivery (WCARHD), Division of Health Sciences, Warwick Medical School, The University of Warwick, Coventry, UK.
[Ti] Título:Depression and adherence to antiretroviral therapy in low-, middle- and high-income countries: a systematic review and meta-analysis.
[So] Fuente:Curr HIV/AIDS Rep;11(3):291-307, 2014 Sep.
[Is] ISSN:1548-3576
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:We investigated the associations between depressive symptoms and adherence to antiretroviral therapy (ART) among people living with HIV (PLHIV). We searched the PubMed, EMBASE and Cochrane CENTRAL databases for studies that reported an association between depression and adherence to ART as a primary or secondary outcome. We used a random-effect model to pool the risk estimates from the individual studies. The odds ratio (OR) with their 95 % CIs were used as summary estimates. Of 2861 citations, 111 studies that recruited 42,366 PLHIV met our inclusion criteria. When reported, the rate of PLHIV with depressive symptoms ranged from 12.8 to 78 % and the proportion of PLHIV who achieved good adherence (≥ 80 %) ranged from 20 to 98 %. There were no significant differences in rate of depressive symptoms in PLHIV by country income group; however, the proportion of PLHIV who achieved good adherence was significantly higher in lower-income countries (as defined in the 2012 World Bank Country Income Groups) (pooled rate=86 %) compared to higher-income countries (pooled rate=67.5 %; p< .05). We found that the likelihood of achieving good ART adherence was 42 % lower among those with depressive symptoms compared to those without (pooled OR=0.58, 95 % CI 0.55 to 0.62). The relationship between depressive symptoms and adherence to ART was consistent across the country's income group, study design and adherence rates. We found that the magnitude of the association significantly decreases with more recent publications and increasing study sample size. The higher the prevalence of depressive symptoms of PLHIV recruited in the studies, the lower the likelihood of achieving good adherence to ART. In conclusion, the likelihood of achieving good adherence was lower among those with depressive symptoms compared to those without.
[Mh] Términos MeSH primario: Fármacos Anti-VIH/uso terapéutico
Depresión/etiología
Infecciones por VIH/complicaciones
Infecciones por VIH/quimioterapia
Cumplimiento de la Medicación/estadística & datos numéricos
[Mh] Términos MeSH secundario: Fármacos Anti-VIH/administración & dosificación
Países Desarrollados
Países en Desarrollo
[Pt] Tipo de publicación:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nombre de substancia:
0 (Anti-HIV Agents)
[Em] Mes de ingreso:1502
[Cu] Fecha actualización por clase:150404
[Lr] Fecha última revisión:150404
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:140805
[St] Status:MEDLINE
[do] DOI:10.1007/s11904-014-0220-1


  7 / 280460 MEDLINE  
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[PMID]:24862329
[Au] Autor:Aiamkitsumrit B; Dampier W; Antell G; Rivera N; Martin-Garcia J; Pirrone V; Nonnemacher MR; Wigdahl B
[Ti] Título:Bioinformatic analysis of HIV-1 entry and pathogenesis.
[So] Fuente:Curr HIV Res;12(2):132-61, 2014.
[Is] ISSN:1873-4251
[Cp] País de publicación:Netherlands
[La] Idioma:eng
[Ab] Resumen:The evolution of human immunodeficiency virus type 1 (HIV-1) with respect to co-receptor utilization has been shown to be relevant to HIV-1 pathogenesis and disease. The CCR5-utilizing (R5) virus has been shown to be important in the very early stages of transmission and highly prevalent during asymptomatic infection and chronic disease. In addition, the R5 virus has been proposed to be involved in neuroinvasion and central nervous system (CNS) disease. In contrast, the CXCR4-utilizing (X4) virus is more prevalent during the course of disease progression and concurrent with the loss of CD4(+) T cells. The dual-tropic virus is able to utilize both co-receptors (CXCR4 and CCR5) and has been thought to represent an intermediate transitional virus that possesses properties of both X4 and R5 viruses that can be encountered at many stages of disease. The use of computational tools and bioinformatic approaches in the prediction of HIV-1 co-receptor usage has been growing in importance with respect to understanding HIV-1 pathogenesis and disease, developing diagnostic tools, and improving the efficacy of therapeutic strategies focused on blocking viral entry. Current strategies have enhanced the sensitivity, specificity, and reproducibility relative to the prediction of co-receptor use; however, these technologies need to be improved with respect to their efficient and accurate use across the HIV-1 subtypes. The most effective approach may center on the combined use of different algorithms involving sequences within and outside of the env-V3 loop. This review focuses on the HIV-1 entry process and on co-receptor utilization, including bioinformatic tools utilized in the prediction of co-receptor usage. It also provides novel preliminary analyses for enabling identification of linkages between amino acids in V3 with other components of the HIV-1 genome and demonstrates that these linkages are different between X4 and R5 viruses.
[Mh] Términos MeSH primario: Biología Computacional/métodos
Infecciones por VIH/metabolismo
Infecciones por VIH/patología
[Mh] Términos MeSH secundario: Humanos
Receptores CCR5/metabolismo
Receptores CXCR4/metabolismo
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; REVIEW
[Nm] Nombre de substancia:
0 (Receptors, CCR5); 0 (Receptors, CXCR4)
[Em] Mes de ingreso:1503
[Cu] Fecha actualización por clase:150404
[Lr] Fecha última revisión:150404
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:140804
[St] Status:MEDLINE


  8 / 280460 MEDLINE  
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[PMID]:25028914
[Au] Autor:Asher AK; Santos GM; Evans J; Dokubo EK; Lee TH; Martin JN; Deeks SG; Tobler LH; Busch M; Hunt PW; Page K
[Ad] Dirección:aDepartment of Community Health Systems, School of Nursing bDepartment of Epidemiology & Biostatistics cDepartment of Medicine, University of California San Francisco dBlood Systems Research Institute, San Francisco, California. USA.
[Ti] Título:A closer look at hepatitis C clearance in HIV controllers: a response.
[So] Fuente:AIDS;28(8):1241-2, 2014 May 15.
[Is] ISSN:1473-5571
[Cp] País de publicación:England
[La] Idioma:eng
[Mh] Términos MeSH primario: Infecciones por VIH/complicaciones
Sobrevivientes de VIH a Largo Plazo
Antígenos HLA-B/genética
Antígenos HLA-B/inmunología
Hepatitis C/complicaciones
Hepatitis C/inmunología
[Mh] Términos MeSH secundario: Femenino
Humanos
Masculino
[Pt] Tipo de publicación:COMMENT; LETTER; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nombre de substancia:
0 (HLA-B Antigens)
[Em] Mes de ingreso:1502
[Cu] Fecha actualización por clase:150404
[Lr] Fecha última revisión:150404
[Sb] Subgrupo de revista:IM; X
[Da] Fecha de ingreso para procesamiento:140717
[St] Status:MEDLINE
[do] DOI:10.1097/QAD.0000000000000208


  9 / 280460 MEDLINE  
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[PMID]:24077929
[Au] Autor:Jeevanjee S; Penko J; Guzman D; Miaskowski C; Bangsberg DR; Kushel MB
[Ti] Título:Opioid analgesic misuse is associated with incomplete antiretroviral adherence in a cohort of HIV-infected indigent adults in San Francisco.
[So] Fuente:AIDS Behav;18(7):1352-8, 2014 Jul.
[Is] ISSN:1573-3254
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:There is little or no data examining the association between either pain or the use or misuse of opioid analgesic with adherence to antiretroviral medications (ARVs) among HIV-infected adults. We interviewed a community-based cohort of HIV-infected indigent adults prescribed antiretroviral medications (ARVs) quarterly to examine the association between (1) pain, (2) receipt of opioid analgesics, and (3) opioid analgesic misuse with self-reported ARV adherence. Of 281 participants, most (82.5 %) reported severe or moderate pain, half (52.4 %) received a prescription for opioids, and one quarter (24.6 %) misused opioid analgesics. Most (71.9 %) reported >90 % ARV adherence. In a GEE model, neither pain (unadjusted OR 1.14, CI 0.90­1.45) nor prescription of opioid analgesics (unadjusted OR 1.11, CI 0.84­1.49) were significantly associated with ARV adherence. Misuse of opioid analgesics was associated with incomplete adherence (AOR 1.42, CI 1.09­1.86). Individuals who misuse opioid analgesics, like those who use illicit substances, may have difficulty adhering to medication regimens.
[Mh] Términos MeSH primario: Analgésicos Opioides/uso terapéutico
Fármacos Anti-VIH/uso terapéutico
Infecciones por VIH/psicología
Cumplimiento de la Medicación
Trastornos Relacionados con Opioides/psicología
Dolor/quimioterapia
[Mh] Términos MeSH secundario: Adolescente
Adulto
Analgésicos Opioides/efectos adversos
Estudios Transversales
Femenino
Infecciones por VIH/complicaciones
Infecciones por VIH/quimioterapia
Humanos
Masculino
Cumplimiento de la Medicación/psicología
Cumplimiento de la Medicación/estadística & datos numéricos
Medicamentos bajo Prescripción
San Francisco
Autoinforme
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nombre de substancia:
0 (Analgesics, Opioid); 0 (Anti-HIV Agents); 0 (Prescription Drugs)
[Em] Mes de ingreso:1502
[Cu] Fecha actualización por clase:150404
[Lr] Fecha última revisión:150404
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:140710
[St] Status:MEDLINE


  10 / 280460 MEDLINE  
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[PMID]:24977311
[Au] Autor:Blashill AJ; Goshe BM; Robbins GK; Mayer KH; Safren SA
[Ad] Dirección:Department of Psychiatry, Massachusetts General Hospital....
[Ti] Título:Body image disturbance and health behaviors among sexual minority men living with HIV.
[So] Fuente:Health Psychol;33(7):677-80, 2014 Jul.
[Is] ISSN:1930-7810
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:OBJECTIVE: Body image disturbance is a common experience for sexual minority men living with HIV, and is associated with poor self-care behaviors. However, to date, no known cohesive theoretical model has been advanced to understand the possible antecedents and outcomes of body image disturbance in this population. Thus, the goal of the current study was to test a biopsychosocial model of body image and self-care behaviors among sexual minority men living with HIV. METHOD: Participants were 106 gay and bisexual men living with HIV who completed a battery of self-report measures, including assessment of body image disturbance, depression, lipodystrophy, appearance orientation, condom use self-efficacy, antiretroviral therapy (ART) adherence, and HIV sexual transmission risk behaviors. Bayesian estimation was employed to assess model fit and direct and indirect pathways within the model. RESULTS: The data fit the model well, with all theorized pathways being significant. Lipodystrophy severity and appearance orientation were associated with elevated body image disturbance. In turn, body image disturbance was related to poorer ART adherence and increased HIV sexual transmission risk behaviors, through the mechanisms of elevated depressive symptoms and poor condom use self-efficacy. CONCLUSIONS: Elevated body image disturbance among sexual minority men living with HIV is associated with important biopsychosocial variables, which in turn are related to poorer ART adherence and increased HIV sexual transmission risk behaviors. Integrative psychosocial interventions addressing co-occurring body image disturbance, depression, and HIV self-care behaviors may be a fruitful area for future clinical practice and research.
[Mh] Términos MeSH primario: Bisexualidad/psicología
Imagen Corporal/psicología
Infecciones por VIH/terapia
Conductas Saludables
Homosexualidad Masculina/psicología
Grupos Minoritarios/psicología
Autocuidado/psicología
[Mh] Términos MeSH secundario: Adulto
Fármacos Anti-VIH/administración & dosificación
Teorema de Bayes
Bisexualidad/estadística & datos numéricos
Condones/utilización
Depresión/psicología
Infecciones por VIH/quimioterapia
Homosexualidad Masculina/estadística & datos numéricos
Humanos
Masculino
Cumplimiento de la Medicación/estadística & datos numéricos
Mediana Edad
Grupos Minoritarios/estadística & datos numéricos
Modelos Psicológicos
Asunción de Riesgos
Conducta Sexual/psicología
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nombre de substancia:
0 (Anti-HIV Agents)
[Em] Mes de ingreso:1503
[Cu] Fecha actualización por clase:150404
[Lr] Fecha última revisión:150404
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:140701
[St] Status:MEDLINE
[do] DOI:10.1037/hea0000081



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