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  1 / 275722 MEDLINE  
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[PMID]:24946781
[Au] Autor:Bulla I; Schultz AK; Chesneau C; Mark T; Serea F
[Ad] Dirección:Institut für Mathematik und Informatik, Universität Greifswald, Walther-Rathenau-Straße 47, 17487 Greifswald, Germany. ingobulla@gmail.com.
[Ti] Título:A model-based information sharing protocol for profile Hidden Markov Models used for HIV-1 recombination detection.
[So] Fuente:BMC Bioinformatics;15:205, 2014.
[Is] ISSN:1471-2105
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:BACKGROUND: In many applications, a family of nucleotide or protein sequences classified into several subfamilies has to be modeled. Profile Hidden Markov Models (pHMMs) are widely used for this task, modeling each subfamily separately by one pHMM. However, a major drawback of this approach is the difficulty of dealing with subfamilies composed of very few sequences. One of the most crucial bioinformatical tasks affected by the problem of small-size subfamilies is the subtyping of human immunodeficiency virus type 1 (HIV-1) sequences, i.e., HIV-1 subtypes for which only a small number of sequences is known. RESULTS: To deal with small samples for particular subfamilies of HIV-1, we introduce a novel model-based information sharing protocol. It estimates the emission probabilities of the pHMM modeling a particular subfamily not only based on the nucleotide frequencies of the respective subfamily but also incorporating the nucleotide frequencies of all available subfamilies. To this end, the underlying probabilistic model mimics the pattern of commonality and variation between the subtypes with regards to the biological characteristics of HI viruses. In order to implement the proposed protocol, we make use of an existing HMM architecture and its associated inference engine. CONCLUSIONS: We apply the modified algorithm to classify HIV-1 sequence data in the form of partial HIV-1 sequences and semi-artificial recombinants. Thereby, we demonstrate that the performance of pHMMs can be significantly improved by the proposed technique. Moreover, we show that our algorithm performs significantly better than Simplot and Bootscanning.
[Mh] Términos MeSH primario: Biología Computacional/métodos
VIH-1/genética
Cadenas de Markov
Modelos Estadísticos
Recombinación Genética
[Mh] Términos MeSH secundario: Algoritmos
Secuencia de Bases
Variación Genética
VIH-1/fisiología
Interacciones Huésped-Patógeno
Humanos
Inmunidad
Modelos Biológicos
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mes de ingreso:1410
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:140725
[St] Status:MEDLINE
[do] DOI:10.1186/1471-2105-15-205


  2 / 275722 MEDLINE  
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[PMID]:25005023
[Au] Autor:Gardner SN; Slezak T
[Ad] Dirección:Computations/Global Security, Lawrence Livermore National Laboratory (LLNL), Livermore, CA 94550, USA. gardner26@llnl.gov.
[Ti] Título:Simulate_PCR for amplicon prediction and annotation from multiplex, degenerate primers and probes.
[So] Fuente:BMC Bioinformatics;15:237, 2014.
[Is] ISSN:1471-2105
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:BACKGROUND: Pairing up primers to amplify desired targets and avoid undesired cross reactions can be a combinatorial challenge. Effective prediction of specificity and inclusivity from multiplexed primers and TaqMan®/Luminex® probes is a critical step in PCR design. RESULTS: Code is described to identify all primer and probe combinations from a list of unpaired, unordered candidates that should produce a product. It predicts and extracts all amplicon sequences in a large sequence database from a list of primers and probes, allowing degenerate bases and user-specified levels of primer-target mismatch tolerance. Amplicons hit by TaqMan®/Luminex® probes are indicated, and products may be annotated with gene information from NCBI. Fragment length distributions are calculated to predict electrophoretic gel banding patterns. CONCLUSIONS: Simulate_PCR is the only freely available software that can be run from the command line for high throughput applications which can calculate all products from large lists of primers and probes compared to a large sequence database such as nt. It requires no prior knowledge of how primers should be paired. Degenerate bases are allowed and entire amplicon sequences are extracted and annotated with gene information. Examples are provided for sets of TaqMan®/Luminex® PCR signatures predicted to amplify all HIV-1 genomes, all Coronaviridae genomes, and a group of antibiotic resistance genes. The software is a command line perl script freely available as open source.
[Mh] Términos MeSH primario: Biología Computacional/métodos
Cartilla de ADN/genética
Sondas de ADN/genética
Anotación de Secuencia Molecular
Programas Informáticos
[Mh] Términos MeSH secundario: Coronaviridae/genética
Farmacorresistencia Microbiana/genética
VIH-1/genética
Humanos
Reacción en Cadena de la Polimerasa
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nombre de substancia:
0 (DNA Primers); 0 (DNA Probes)
[Em] Mes de ingreso:1410
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:140718
[St] Status:MEDLINE
[do] DOI:10.1186/1471-2105-15-237


  3 / 275722 MEDLINE  
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[PMID]:24070647
[Au] Autor:Gullette D; Booth BM; Wright PB; Montgomery BE; Stewart KE
[Ti] Título:Sexual sensation seeking, transactional sex, and rural African American cocaine users.
[So] Fuente:J Assoc Nurses AIDS Care;25(4):289-96, 2014 Jul-Aug.
[Is] ISSN:1552-6917
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:The purpose of this study was to explore correlates of sexual sensation seeking (SSS) in a sample of rural African American cocaine users. Respondent-driven sampling was used to recruit 251 participants from two impoverished rural counties in eastern Arkansas. Consistent with previous investigations, SSS scores were associated with being younger, being male, having more sexual partners, and having more unprotected sexual encounters in the previous 30 days. Multiple regression revealed that SSS was correlated with a number of oral sex acts, transactional sex (exchanging sex for food, shelter, drugs, money, or other commodities), and Addiction Severity Index drug composite. SSS continues to demonstrate a strong association with sexual risk behaviors in diverse populations, including vulnerable groups like this community. Interventions to reduce unsafe sexual behaviors among high-risk groups, including drug users and individuals who engage in transactional sex, should incorporate approaches that include high sensation seekers' needs for novelty and variety.
[Mh] Términos MeSH primario: Afroamericanos/psicología
Trastornos Relacionados con Cocaína/etnología
Prostitución/etnología
Conducta Sexual/psicología
[Mh] Términos MeSH secundario: Adolescente
Adulto
Afroamericanos/estadística & datos numéricos
Trastornos Relacionados con Cocaína/psicología
Estudios Transversales
Conducta Exploratoria
Femenino
Infecciones por VIH/etnología
Infecciones por VIH/psicología
Infecciones por VIH/transmisión
Humanos
Entrevistas como Asunto
Masculino
Mediana Edad
Prostitución/psicología
Prostitución/estadística & datos numéricos
Cuestionarios
Análisis de Regresión
Factores de Riesgo
Asunción de Riesgos
Población Rural/estadística & datos numéricos
Conducta Sexual/etnología
Conducta Sexual/estadística & datos numéricos
Parejas Sexuales/psicología
Sexo Inseguro/etnología
Sexo Inseguro/psicología
Sexo Inseguro/estadística & datos numéricos
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Em] Mes de ingreso:1409
[Cu] Fecha actualización por clase:141011
[Lr] Fecha última revisión:141011
[Sb] Subgrupo de revista:IM; N; X
[Da] Fecha de ingreso para procesamiento:140613
[St] Status:MEDLINE


  4 / 275722 MEDLINE  
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[PMID]:23421994
[Au] Autor:Wilson S; Derlega VJ; Woody A; Lewis R; Braitman AL; Barbee A; Winstead BA
[Ad] Dirección:Virginia Consortium Program in Clinical Psychology, USA.
[Ti] Título:Disentangling reactions to HIV disclosure: effects of HIV status, sexual orientation, and disclosure recipients' gender.
[So] Fuente:J Health Psychol;19(2):285-95, 2014 Feb.
[Is] ISSN:1461-7277
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:This experiment examined how reactions to HIV disclosure by a male stimulus person are influenced by the discloser's HIV status and sexual orientation as well as the disclosure recipient's gender. Participants (152 male and female college students) disclosed more intimately about themselves (revealing highly personal facts and personal feelings) when the man's HIV test result was positive versus negative. The effects of HIV status disclosure on participants' self-disclosure and social support were also moderated by the man's sexual orientation and participants' gender. The results document circumstances when HIV disclosure may lead to positive reactions instead of avoidance and exclusion.
[Mh] Términos MeSH primario: Seropositividad para VIH/psicología
Autorrevelación
Sexualidad/psicología
Apoyo Social
Revelación de la Verdad
[Mh] Términos MeSH secundario: Adulto
Femenino
Humanos
Masculino
Factores Sexuales
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE
[Em] Mes de ingreso:1410
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:140121
[St] Status:MEDLINE
[do] DOI:10.1177/1359105312470155


  5 / 275722 MEDLINE  
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[PMID]:23300046
[Au] Autor:Brion JM; Leary MR; Drabkin AS
[Ad] Dirección:Duke University, USA.
[Ti] Título:Self-compassion and reactions to serious illness: the case of HIV.
[So] Fuente:J Health Psychol;19(2):218-29, 2014 Feb.
[Is] ISSN:1461-7277
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:To test the hypothesis that self-compassion buffers people against the emotional impact of illness and is associated with medical adherence, 187 HIV-infected individuals completed a measure of self-compassion and answered questions about their emotional and behavioral reactions to living with HIV. Self-compassion was related to better adjustment, including lower stress, anxiety, and shame. Participants higher in self-compassion were more likely to disclose their HIV status to others and indicated that shame had less of an effect on their willingness to practice safe sex and seek medical care. In general, self-compassion was associated with notably more adaptive reactions to having HIV.
[Mh] Términos MeSH primario: Adaptación Psicológica/fisiología
Infecciones por VIH/psicología
Autoimagen
[Mh] Términos MeSH secundario: Adulto
Anciano
Ansiedad/etiología
Ansiedad/psicología
Femenino
Humanos
Masculino
Mediana Edad
Vergüenza
Estrés Psicológico/etiología
Estrés Psicológico/psicología
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mes de ingreso:1410
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:140121
[St] Status:MEDLINE
[do] DOI:10.1177/1359105312467391


  6 / 275722 MEDLINE  
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[PMID]:24361679
[Au] Autor:Li JZ; Gallien S; Ribaudo H; Heisey A; Bangsberg DR; Kuritzkes DR
[Ad] Dirección:aBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA bHôpital Saint Louis, Paris, France cCenter for Biostatistics in AIDS Research, Harvard School of Public Health dMassachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. *Jonathan Z. Li and Sebastien Gallien contributed equally to the writing of this article.
[Ti] Título:Incomplete adherence to antiretroviral therapy is associated with higher levels of residual HIV-1 viremia.
[So] Fuente:AIDS;28(2):181-6, 2014 Jan 14.
[Is] ISSN:1473-5571
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:OBJECTIVES: To evaluate the relationship between incomplete antiretroviral therapy (ART) adherence and levels of residual HIV-1 viremia. DESIGN: Medication adherence and residual viremia less than 50 copies/ml were quantified in participants of a cohort of homeless and marginally housed individuals with HIV/AIDS. METHODS: Participants had at least 6 months of virologic suppression of less than 50 copies/ml and were in the adherence monitoring cohort with monthly unannounced pill counts. Residual viremia was measured by the single-copy assay. RESULTS: The median average ART adherence over the prior 1 and 2 months were 94% [interquartile range (IQR) 79-100%] and 93% (IQR 82-98%), respectively. Average ART adherence over the past 2 months was significantly associated with levels of residual HIV viremia (Spearman r = -0.25, P = 0.04). One-third of participants with 100% ART adherence over the past 2 months had detectable residual viremia. On multivariate regression analysis, ART adherence over the past 2 months, but not duration of virologic suppression, CD4 T-cell count or ART regimen, was significantly associated with levels of residual HIV viremia. Detectable residual viremia was associated with virologic failure (>50 copies/ml) on univariate Cox proportional hazard analysis (hazard ratio 2.08, P = 0.02). However, on multivariate analysis, only ART adherence was associated with risk of virologic failure. CONCLUSION: Incomplete ART adherence is associated with higher levels of residual HIV-1 viremia, but detectable residual viremia can be present despite 100% measured ART adherence.
[Mh] Términos MeSH primario: Antirretrovirales/administración & dosificación
Terapia Antirretroviral Altamente Activa/métodos
Infecciones por VIH/quimioterapia
VIH-1/aislamiento & purificación
Cumplimiento de la Medicación/estadística & datos numéricos
Carga Viral
Viremia
[Mh] Términos MeSH secundario: Adulto
Femenino
Infecciones por VIH/virología
Humanos
Masculino
Mediana Edad
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nombre de substancia:
0 (Anti-Retroviral Agents)
[Em] Mes de ingreso:1409
[Cu] Fecha actualización por clase:141011
[Lr] Fecha última revisión:141011
[Sb] Subgrupo de revista:IM; X
[Da] Fecha de ingreso para procesamiento:140113
[St] Status:MEDLINE
[do] DOI:10.1097/QAD.0000000000000123


  7 / 275722 MEDLINE  
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[PMID]:24199837
[Au] Autor:Thota VN; Brahmaiah M; Kulkarni SS
[Ad] Dirección:Department of Chemistry, Indian Institute of Technology Bombay , Mumbai 400076, India.
[Ti] Título:Synthesis of a C-glycoside analogue of ß-galactosyl ceramide, a potential HIV-1 entry inhibitor.
[So] Fuente:J Org Chem;78(23):12082-9, 2013 Dec 6.
[Is] ISSN:1520-6904
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:A ß-C-galactosyl ceramide was synthesized in a stereoselective manner, employing a Sharpless AD reaction and olefin cross metathesis as key steps.
[Mh] Términos MeSH primario: Fármacos Anti-VIH/farmacología
Ceramidas/farmacología
VIH-1/efectos de drogas
Monosacáridos/farmacología
[Mh] Términos MeSH secundario: Fármacos Anti-VIH/síntesis química
Fármacos Anti-VIH/química
Ceramidas/síntesis química
Ceramidas/química
Pruebas de Sensibilidad Microbiana
Conformación Molecular
Monosacáridos/síntesis química
Monosacáridos/química
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nombre de substancia:
0 (Anti-HIV Agents); 0 (Ceramides); 0 (Monosaccharides); 0 (beta-galactosyl ceramide)
[Em] Mes de ingreso:1410
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:131206
[St] Status:MEDLINE
[do] DOI:10.1021/jo402115w


  8 / 275722 MEDLINE  
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[PMID]:24056744
[Au] Autor:Begolo S; Shen F; Ismagilov RF
[Ad] Dirección:Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. rustem.admin@caltech.edu.
[Ti] Título:A microfluidic device for dry sample preservation in remote settings.
[So] Fuente:Lab Chip;13(22):4331-42, 2013 Nov 21.
[Is] ISSN:1473-0189
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:This paper describes a microfluidic device for dry preservation of biological specimens at room temperature that incorporates chemical stabilization matrices. Long-term stabilization of samples is crucial for remote medical analysis, biosurveillance, and archiving, but the current paradigm for transporting remotely obtained samples relies on the costly "cold chain" to preserve analytes within biospecimens. We propose an alternative approach that involves the use of microfluidics to preserve samples in the dry state with stabilization matrices, developed by others, that are based on self-preservation chemistries found in nature. We describe a SlipChip-based device that allows minimally trained users to preserve samples with the three simple steps of placing a sample at an inlet, closing a lid, and slipping one layer of the device. The device fills automatically, and a pre-loaded desiccant dries the samples. Later, specimens can be rehydrated and recovered for analysis in a laboratory. This device is portable, compact, and self-contained, so it can be transported and operated by untrained users even in limited-resource settings. Features such as dead-end and sequential filling, combined with a "pumping lid" mechanism, enable precise quantification of the original sample's volume while avoiding overfilling. In addition, we demonstrated that the device can be integrated with a plasma filtration module, and we validated device operations and capabilities by testing the stability of purified RNA solutions. These features and the modularity of this platform (which facilitates integration and simplifies operation) would be applicable to other microfluidic devices beyond this application. We envision that as the field of stabilization matrices develops, microfluidic devices will be useful for cost-effectively facilitating remote analysis and biosurveillance while also opening new opportunities for diagnostics, drug development, and other medical fields.
[Mh] Términos MeSH primario: Pruebas con Sangre Seca/métodos
Técnicas Analíticas Microfluídicas/instrumentación
[Mh] Términos MeSH secundario: Pruebas con Sangre Seca/instrumentación
VIH-1/genética
Humanos
Reacción en Cadena de la Polimerasa
Estabilidad del ARN
ARN Viral/análisis
ARN Viral/aislamiento & purificación
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nombre de substancia:
0 (RNA, Viral)
[Em] Mes de ingreso:1405
[Cu] Fecha actualización por clase:141011
[Lr] Fecha última revisión:141011
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:131017
[St] Status:MEDLINE
[do] DOI:10.1039/c3lc50747e


  9 / 275722 MEDLINE  
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[PMID]:23979000
[Au] Autor:Fitzpatrick ME; Gingo MR; Kessinger C; Lucht L; Kleerup E; Greenblatt RM; Claman D; Ponath C; Fong S; Huang L; Morris A
[Ad] Dirección:*Department of Medicine, University of Pittsburgh, Pittsburgh, PA; †Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA; ‡Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA; Departments of §Medicine; ‖Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, CA; and ¶Department of Immunology, University of Pittsburgh, Pittsburgh, PA.
[Ti] Título:HIV infection is associated with diffusing capacity impairment in women.
[So] Fuente:J Acquir Immune Defic Syndr;64(3):284-8, 2013 Nov 1.
[Is] ISSN:1944-7884
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Respiratory dysfunction is common with HIV infection, but few studies have directly assessed whether HIV remains an independent risk factor for pulmonary function abnormalities in the antiretroviral therapy era. Additionally, few studies have focused on pulmonary outcomes in HIV+ women. We tested associations between risk factors for respiratory dysfunction and pulmonary outcomes in 63 HIV+ and 36 HIV-uninfected women enrolled in the Women's Interagency HIV Study. Diffusing capacity (DL(CO)) was significantly lower in HIV+ women (65.5% predicted vs. 72.7% predicted, P = 0.01), and self-reported dyspnea in HIV+ participants was associated with both DL(CO) impairment and airflow obstruction. Providers should be aware that DL(CO) impairment is common in HIV infection, and that either DL(CO) impairment or airflow obstruction may cause respiratory symptoms in this population.
[Mh] Términos MeSH primario: Disnea/fisiopatología
Infecciones por VIH/fisiopatología
Capacidad de Difusión Pulmonar
Insuficiencia Respiratoria/fisiopatología
[Mh] Términos MeSH secundario: Adulto
Recuento de Linfocito CD4
Disnea/etiología
Disnea/virología
Femenino
Infecciones por VIH/complicaciones
Humanos
Mediana Edad
Prevalencia
Insuficiencia Respiratoria/etiología
Insuficiencia Respiratoria/virología
Factores de Riesgo
Hábito de Fumar/efectos adversos
Espirometría
Estados Unidos/epidemiología
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mes de ingreso:1401
[Cu] Fecha actualización por clase:141011
[Lr] Fecha última revisión:141011
[Sb] Subgrupo de revista:IM; X
[Da] Fecha de ingreso para procesamiento:131016
[St] Status:MEDLINE
[do] DOI:10.1097/QAI.0b013e3182a9213a


  10 / 275722 MEDLINE  
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PubMed Central Texto completo
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[PMID]:23979356
[Au] Autor:Pham P; Landolph A; Mendez C; Li N; Goodman MF
[Ad] Dirección:From the Departments of Biological Sciences and Chemistry, Molecular and Computational Biology Section, University of Southern California, Los Angeles, California 90089-2910.
[Ti] Título:A biochemical analysis linking APOBEC3A to disparate HIV-1 restriction and skin cancer.
[So] Fuente:J Biol Chem;288(41):29294-304, 2013 Oct 11.
[Is] ISSN:1083-351X
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Human deoxycytidine deaminase APOBEC3A (Apo3A) acts as an HIV-1 restriction factor in cells of myeloid lineage yet functions separately as a potent mutator for genomic DNA. Apo3A activity and C motif deamination specificity exhibit a striking dependence on pH that reflects these two distinct biological processes. Upon infection of macrophages, HIV-1 induces the formation of autophagosomes, and requires autophagosomes for replication, whereas inhibiting lysosomal fusion indicative of late stage autophagy. Here we show that Apo3A has optimal activity and a strict 5'-YYCR motif specificity in the pH 5.8-6.1 range, characteristic of enclosed autophagosomal membrane compartments, and reflective of the mutation pattern of HIV-1. In contrast to the high activity and narrow specificity of Apo3A at acid pH, a 13-30-fold reduction in specific activity is accompanied by relaxed C deamination specificity at pH 7.4-8. Notably, Apo3A is also expressed in keratinocytes, and is up-regulated in skin lesions. At pH 7.9, we show that Apo3A generates transcription-dependent CC → TT tandem mutations on the non-transcribed strand, a hallmark signature of skin cancer. The biochemical data taken in conjunction with the biological up-regulation of Apo3A in skin lesions suggests that enzyme-catalyzed deaminations at adjacent C sites followed by normal replication generating CC → TT mutations provides an alternative molecular basis for the initiation events in skin cancer in contrast to well established pathways in which CC dimers formed in response to UV radiation either undergo nonenzymatic spontaneous deaminations or aberrant replication.
[Mh] Términos MeSH primario: Citidina Desaminasa/metabolismo
VIH-1/fisiología
Proteínas/metabolismo
Neoplasias Cutáneas/metabolismo
[Mh] Términos MeSH secundario: Secuencia de Aminoácidos
Animales
Anisotropía
Secuencia de Bases
Citidina Desaminasa/química
Citidina Desaminasa/genética
ADN de Cadena Simple/genética
ADN de Cadena Simple/metabolismo
Electroforesis en Gel de Poliacrilamida
Fluorometría
VIH-1/genética
Humanos
Concentración de Iones de Hidrógeno
Queratinocitos/metabolismo
Macrófagos/metabolismo
Macrófagos/virología
Mutación
Motivos de Nucleótidos/genética
Unión Proteica
Proteínas/química
Proteínas/genética
Células Sf9
Neoplasias Cutáneas/genética
Especificidad por Sustrato
Regulación hacia Arriba
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nombre de substancia:
0 (DNA, Single-Stranded); 0 (Proteins); EC 3.5.4.5 (APOBEC3A protein, human); EC 3.5.4.5 (Cytidine Deaminase)
[Em] Mes de ingreso:1312
[Cu] Fecha actualización por clase:141011
[Lr] Fecha última revisión:141011
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:131014
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M113.504175



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BIREME/OPS/OMS - Centro Latinoamericano y del Caribe de Información en Ciencias de la Salud