Base de datos : MEDLINE
Búsqueda : sida or vih [Palabras]
Referencias encontradas : 275916 [refinar]
Mostrando: 1 .. 10   en el formato [Detallado]

página 1 de 27592 va a la página                         

  1 / 275916 MEDLINE  
              next record last record
selecciona
para imprimir
Fotocopia
Texto completo
[PMID]:24681563
[Au] Autor:Somé JF; Desclaux A; Ky-Zerbo O; Lougué M; Kéré S; Obermeyer C; Simaga F
[Ad] Dirección:Programme d'appui au monde associatif et communautaire (Pamac)/Programme d'appui aux organisations de la société civile impliquées dans la riposte contre le sida au Togo (Pasci). 01 BP 2753 Lomé 01, Togo....
[Ti] Título:[Campaigns for HIV testing, an effective strategy for universal access to prevention and treatment? The experience of Burkina Faso].
[Ti] Título:Les campagnes de dépistage du VIH, une stratégie efficace pour l'accès universel à la prévention et au traitement ? L'expérience du Burkina Faso..
[So] Fuente:Med Sante Trop;24(1):73-9, 2014 Jan-Mar.
[Is] ISSN:2261-2211
[Cp] País de publicación:France
[La] Idioma:fre
[Ab] Resumen:OBJECTIVES: Increasing the rate of people who know their HIV status is imperative, particularly in sub Saharan Africa, and this requires an assessment of strategies for increasing the utilization of testing services. This article discusses the relevance, feasibility, and effectiveness of national screening campaigns conducted between 2006 and 2010 in Burkina Faso. METHODOLOGY: An analysis of all data regarding testing uptake from 2006 to 2010 was conducted, along with interviews of key participants in the process. RESULTS: The results show that the 8 screening campaigns led to HIV testing of 487,727 people, that is, 50% of the total number of people tested and 24.6 % of HIV+ people diagnosed during this period. Campaigns succeeded in testing populations that are difficult to reach (especially young people), at a low cost. CONCLUSIONS: This strategy is relevant and useful for identifying HIV+ people. Its utility for HIV prevention campaigns requires further study. Campaigns are effective and cost-effective even in this country with a low disease prevalence. These results underline the importance of the synergy between community-based organizations and health services in the provision of counseling and testing.
[Pt] Tipo de publicación:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mes de ingreso:1404
[Sb] Subgrupo de revista:IM
[St] Status:In-Process
[do] DOI:10.1684/mst.2014.0298


  2 / 275916 MEDLINE  
              first record previous record next record last record
selecciona
para imprimir
Fotocopia
Texto completo
[PMID]:24133182
[Au] Autor:Nunoya J; Washburn ML; Kovalev GI; Su L
[Ad] Dirección:Lineberger Comprehensive Cancer Center.
[Ti] Título:Regulatory T cells prevent liver fibrosis during HIV type 1 infection in a humanized mouse model.
[So] Fuente:J Infect Dis;209(7):1039-44, 2014 Apr 1.
[Is] ISSN:1537-6613
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Human immunodeficiency virus type 1 (HIV-1) disease is associated with aberrant immune activation, and coinfection with hepatitis C virus (HCV) exacerbates hepatic inflammation and fibrosis. However, the role of HIV-1 infection or host immune modulation in liver pathogenesis is not clearly defined. Here, we report that regulatory T (Treg) cells prevent liver immunopathogenesis during HIV-1 infection in a humanized mouse model. In the absence of Treg cells, HIV-1 infection induced liver fibrosis associated with hepatic stellate cell activation, hepatitis, and liver injury. Our findings provide new insight linking Treg cells and liver immunopathogenesis during HIV-1 infection.
[Mh] Términos MeSH primario: Coinfección/complicaciones
Infecciones por VIH/complicaciones
Hepatitis C/complicaciones
Cirrosis Hepática/prevención & control
Linfocitos T Reguladores/inmunología
[Mh] Términos MeSH secundario: Animales
Coinfección/inmunología
Modelos Animales de Enfermedad
Infecciones por VIH/inmunología
VIH-1/inmunología
VIH-1/aislamiento & purificación
Hepacivirus/inmunología
Hepacivirus/aislamiento & purificación
Hepatitis C/inmunología
Humanos
Ratones
Ratones SCID
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mes de ingreso:1405
[Cu] Fecha actualización por clase:141018
[Lr] Fecha última revisión:141018
[Sb] Subgrupo de revista:AIM; IM
[Da] Fecha de ingreso para procesamiento:140314
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jit548


  3 / 275916 MEDLINE  
              first record previous record next record last record
selecciona
para imprimir
Fotocopia
Registro de Ensayos Clínicos
Texto completo
[PMID]:24136113
[Au] Autor:Wheeler AL; Scherzer R; Lee D; Delaney JA; Bacchetti P; Shlipak MG; Sidney S; Grunfeld C; Tien PC; Study of Fat Redistribution and Metabolic Change in HIV Infection (FRAM)
[Ad] Dirección:aDepartment of Medicine, University of California San Francisco bDivision of Endocrinology and Metabolism, Department of Veterans Affairs Medical Center San Francisco, San Francisco cDepartment of Medicine, University of California, San Diego School of Medicine, San Diego, California dDepartment of Epidemiology, University of Washington, Seattle, Washington eDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco fDivision of Research, Kaiser Permanente, Oakland, California, USA.
[Ti] Título:HIV/hepatitis C virus coinfection ameliorates the atherogenic lipoprotein abnormalities of HIV infection.
[So] Fuente:AIDS;28(1):49-58, 2014 Jan 2.
[Is] ISSN:1473-5571
[Cp] País de publicación:England
[La] Idioma:eng
[Ab] Resumen:BACKGROUND: Higher levels of small low-density lipoprotein (LDL) and lower levels of high-density lipoprotein (HDL) subclasses have been associated with increased risk of cardiovascular disease. The extent to which HIV infection and HIV/hepatitis C virus (HCV) coinfection are associated with abnormalities of lipoprotein subclasses is unknown. METHODS: Lipoprotein subclasses were measured by nuclear magnetic resonance (NMR) spectroscopy in plasma samples from 569 HIV-infected and 5948 control participants in the Fat Redistribution and Metabolic Change in HIV Infection (FRAM), Coronary Artery Risk Development in Young Adults (CARDIA), and Multi-Ethnic Study of Atherosclerosis (MESA) studies. Multivariable regression was used to estimate the association of HIV and HIV/HCV coinfection with lipoprotein measures with adjustment for demographics, lifestyle factors, and waist-to-hip ratio. RESULTS: Relative to controls, small LDL levels were higher in HIV-monoinfected persons (+381 nmol/l, P <0.0001), with no increase seen in HIV/HCV coinfection (-16.6 nmol/l). Levels of large LDL levels were lower (-196 nmol/l, P <0.0001) and small HDL were higher (+8.2 µmol/l, P < 0.0001) in HIV monoinfection with intermediate values seen in HIV/HCV coinfection. Large HDL levels were higher in HIV/HCV-coinfected persons relative to controls (+1.70 µmol/l, P <0.0001), whereas little difference was seen in HIV-monoinfected persons (+0.33, P = 0.075). Within HIV-infected participants, HCV was associated independently with lower levels of small LDL (-329 nmol/l, P <0.0001) and small HDL (-4.6 µmol/l, P <0.0001), even after adjusting for demographic and traditional cardiovascular risk factors. CONCLUSION: HIV-monoinfected participants had worse levels of atherogenic LDL lipoprotein subclasses compared with controls. HIV/HCV coinfection attenuates these changes, perhaps by altering hepatic factors affecting lipoprotein production and/or metabolism. The effect of HIV/HCV coinfection on atherosclerosis and the clinical consequences of low small subclasses remain to be determined.
[Mh] Términos MeSH primario: Coinfección/parasitología
Infecciones por VIH/complicaciones
Hepatitis C Crónica/complicaciones
Lipoproteínas HDL/sangre
Lipoproteínas LDL/sangre
[Mh] Términos MeSH secundario: Adolescente
Adulto
Anciano
Femenino
Humanos
Espectroscopía de Resonancia Magnética
Masculino
Mediana Edad
Plasma/química
Adulto Joven
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nombre de substancia:
0 (Lipoproteins, HDL); 0 (Lipoproteins, LDL)
[Em] Mes de ingreso:1408
[Cu] Fecha actualización por clase:141018
[Lr] Fecha última revisión:141018
[Sb] Subgrupo de revista:IM; X
[Da] Fecha de ingreso para procesamiento:140113
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1097/QAD.0000000000000026


  4 / 275916 MEDLINE  
              first record previous record next record last record
selecciona
para imprimir
Fotocopia
PubMed Central Texto completo
Texto completo
[PMID]:24386119
[Au] Autor:Djawe K; Daly KR; Levin L; Zar HJ; Walzer PD
[Ad] Dirección:Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America....
[Ti] Título:Humoral immune responses to Pneumocystis jirovecii antigens in HIV-infected and uninfected young children with pneumocystis pneumonia.
[So] Fuente:PLoS One;8(12):e82783, 2013.
[Is] ISSN:1932-6203
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:BACKGROUND: Humoral immune responses in human immunodeficiency virus (HIV)-infected and uninfected children with Pneumocystis pneumonia (PcP) are poorly understood. METHODS: Consecutive children hospitalized with acute pneumonia, tachypnea, and hypoxia in South Africa were investigated for PcP, which was diagnosed by real-time polymerase chain reaction on lower respiratory tract specimens. Serum antibody responses to recombinant fragments of the carboxyl terminus of Pneumocystis jirovecii major surface glycoprotein (MsgC) were analyzed. RESULTS: 149 children were enrolled of whom 96 (64%) were HIV-infected. PcP occurred in 69 (72%) of HIV-infected and 14 (26%) of HIV-uninfected children. HIV-infected children with PcP had significantly decreased IgG antibodies to MsgC compared to HIV-infected patients without PcP, but had similar IgM antibodies. In contrast, HIV-uninfected children with PcP showed no change in IgG antibodies to MsgC, but had significantly increased IgM antibodies compared to HIV-uninfected children without PCP. Age was an independent predictor of high IgG antibodies, whereas PcP was a predictor of low IgG antibodies and high IgM antibodies. IgG and IgM antibody levels to the most closely related MsgC fragments were predictors of survival from PcP. CONCLUSIONS: Young HIV-infected children with PcP have significantly impaired humoral immune responses to MsgC, whereas HIV-uninfected children with PcP can develop active humoral immune responses. The children also exhibit a complex relationship between specific host factors and antibody levels to MsgC fragments that may be related to survival from PcP.
[Mh] Términos MeSH primario: Antígenos Fúngicos/inmunología
Infecciones por VIH/complicaciones
Inmunidad Humoral/fisiología
Pneumocystis jirovecii/inmunología
Neumonía por Pneumocystis/complicaciones
[Mh] Términos MeSH secundario: Factores de Edad
Niño
Humanos
Inmunoglobulina G/sangre
Inmunoglobulina M/sangre
Neumonía por Pneumocystis/inmunología
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nombre de substancia:
0 (Antigens, Fungal); 0 (Immunoglobulin G); 0 (Immunoglobulin M)
[Em] Mes de ingreso:1409
[Cu] Fecha actualización por clase:141018
[Lr] Fecha última revisión:141018
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:140103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0082783


  5 / 275916 MEDLINE  
              first record previous record next record last record
selecciona
para imprimir
Fotocopia
PubMed Central Texto completo
Texto completo
[PMID]:24244375
[Au] Autor:Nookala AR; Shah A; Noel RJ; Kumar A
[Ad] Dirección:Division of Pharmacology and Toxicology, UMKC-School of Pharmacy, Kansas City, Missouri, United States of America.
[Ti] Título:HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-κB, AP-1, C/EBPα and C/EBPγ transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways.
[So] Fuente:PLoS One;8(11):e78855, 2013.
[Is] ISSN:1932-6203
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:The incidence of HIV-associated neurological disorders (HAND) has increased during recent years even though the highly active antiretroviral therapy (HAART) has significantly curtailed the virus replication and increased the life expectancy among HIV-1 infected individuals. These neurological deficits have been attributed to HIV proteins including HIV-1 Tat. HIV-1 Tat is known to up-regulate CCL5 expression in mouse astrocytes, but the mechanism of up-regulation is not known. The present study was undertaken with the objective of determining the mechanism(s) underlying HIV-1 Tat-mediated expression of CCL5 in astrocytes. SVGA astrocytes were transiently transfected with a plasmid encoding Tat, and expression of CCL5 was studied at the mRNA and protein levels using real time RT-PCR and multiplex cytokine bead array, respectively. HIV-1 Tat showed a time-dependent increase in the CCL5 expression with peak mRNA and protein levels, observed at 1 h and 48 h post-transfection, respectively. In order to explore the mechanism(s), pharmacological inhibitors and siRNA against different pathway(s) were used. Pre-treatment with SC514 (NF-κB inhibitor), LY294002 (PI3K inhibitor), AG490 (JAK2 inhibitor) and Janex-1 (JAK3 inhibitor) showed partial reduction of the Tat-mediated induction of CCL5 suggesting involvement of JAK, PI3K/Akt and NF-κB in CCL5 expression. These results were further confirmed by knockdown of the respective genes using siRNA. Furthermore, p38 MAPK was found to be involved since the knockdown of p38δ but not other isoforms showed partial reduction in CCL5 induction. This was further confirmed at transcriptional level that AP-1, C/EBPα and C/EBPγ were involved in CCL5 up-regulation.
[Mh] Términos MeSH primario: Astrocitos/metabolismo
Proteínas Potenciadoras de Unión a CCAAT/metabolismo
Quimiocina CCL5/metabolismo
VIH-1/metabolismo
Quinasas Janus/metabolismo
Sistema de Señalización de Quinasas PAM
FN-kappa B/metabolismo
Fosfatidilinositol 3-Quinasas/metabolismo
Proteínas Proto-Oncogénicas c-akt/metabolismo
Factor de Transcripción AP-1/metabolismo
Proteinas Quinasas Activadas por Mitógeno p38/metabolismo
Productos del Gen tat del Virus de la Inmunodeficiencia Humana/metabolismo
[Mh] Términos MeSH secundario: Complejo SIDA Demencia/metabolismo
Complejo SIDA Demencia/patología
Animales
Astrocitos/patología
Proteínas Potenciadoras de Unión a CCAAT/genética
Quimiocina CCL5/genética
VIH-1/genética
Humanos
Quinasas Janus/genética
Ratones
FN-kappa B/genética
Fosfatidilinositol 3-Quinasas/genética
Proteínas Proto-Oncogénicas c-akt/genética
Factor de Transcripción AP-1/genética
Proteinas Quinasas Activadas por Mitógeno p38/genética
Productos del Gen tat del Virus de la Inmunodeficiencia Humana/genética
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nombre de substancia:
0 (CCAAT-Enhancer-Binding Proteins); 0 (CCAAT-enhancer-binding protein-gamma); 0 (CCL5 protein, human); 0 (CEBPA protein, human); 0 (CEBPA protein, mouse); 0 (Ccl5 protein, mouse); 0 (Chemokine CCL5); 0 (NF-kappa B); 0 (Transcription Factor AP-1); 0 (tat Gene Products, Human Immunodeficiency Virus); 136958-00-4 (Cebpg protein, mouse); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.10.2 (Janus Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
[Em] Mes de ingreso:1408
[Cu] Fecha actualización por clase:141018
[Lr] Fecha última revisión:141018
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:131118
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0078855


  6 / 275916 MEDLINE  
              first record previous record next record last record
selecciona
para imprimir
Fotocopia
PubMed Central Texto completo
Texto completo
[PMID]:24138880
[Au] Autor:Deeks SG; Tracy R; Douek DC
[Ad] Dirección:University of California, San Francisco, San Francisco, CA 94114, USA. Electronic address: sdeeks@php.ucsf.edu.
[Ti] Título:Systemic effects of inflammation on health during chronic HIV infection.
[So] Fuente:Immunity;39(4):633-45, 2013 Oct 17.
[Is] ISSN:1097-4180
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Combination antiretroviral therapy for HIV infection improves immune function and eliminates the risk of AIDS-related complications but does not restore full health. HIV-infected adults have excess risk of cardiovascular, liver, kidney, bone, and neurologic diseases. Many markers of inflammation are elevated in HIV disease and strongly predictive of the risk of morbidity and mortality. A conceptual model has emerged to explain this syndrome of diseases where HIV-mediated destruction of gut mucosa leads to local and systemic inflammation. Translocated microbial products then pass through the liver, contributing to hepatic damage, impaired microbial clearance, and impaired protein synthesis. Chronic activation of monocytes and altered liver protein synthesis subsequently contribute to a hypercoagulable state. The combined effect of systemic inflammation and excess clotting on tissue function leads to end-organ disease. Multiple therapeutic interventions designed to reverse these pathways are now being tested in the clinic. It is likely that knowledge gained on how inflammation affects health in HIV disease could have implications for our understanding of other chronic inflammatory diseases and the biology of aging.
[Mh] Términos MeSH primario: Infecciones por VIH/inmunología
VIH/inmunología
Mucosa Intestinal/inmunología
Trombofilia/inmunología
[Mh] Términos MeSH secundario: Factores de Edad
Fármacos Anti-VIH/uso terapéutico
Antiinflamatorios/uso terapéutico
Enfermedad Crónica
Infecciones por VIH/complicaciones
Infecciones por VIH/quimioterapia
Infecciones por VIH/fisiopatología
Humanos
Inmunidad Innata
Inflamación/etiología
Inflamación/inmunología
Inflamación/fisiopatología
Mucosa Intestinal/fisiopatología
Hígado/inmunología
Hígado/fisiopatología
Modelos Inmunológicos
Monocitos/inmunología
Monocitos/patología
Insuficiencia Multiorgánica/etiología
Insuficiencia Multiorgánica/inmunología
Insuficiencia Multiorgánica/fisiopatología
Biosíntesis de Proteínas/inmunología
Trombofilia/quimioterapia
Trombofilia/etiología
Trombofilia/fisiopatología
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nombre de substancia:
0 (Anti-HIV Agents); 0 (Anti-Inflammatory Agents)
[Em] Mes de ingreso:1312
[Cu] Fecha actualización por clase:141018
[Lr] Fecha última revisión:141018
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:131021
[St] Status:MEDLINE


  7 / 275916 MEDLINE  
              first record previous record next record last record
selecciona
para imprimir
Fotocopia
PubMed Central Texto completo
Texto completo
[PMID]:24138878
[Au] Autor:Schmitt N; Ueno H
[Ad] Dirección:Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75204, USA.
[Ti] Título:Blood Tfh cells come with colors.
[So] Fuente:Immunity;39(4):629-30, 2013 Oct 17.
[Is] ISSN:1097-4180
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:Blood CXCR5⁺ CD4⁺ T cells share phenotypic and functional similarities with T follicular helper cells. Studies by He et al. (2013) and Locci et al. (2013) in this issue of Immunity provide insight into their ontogeny and functionally distinct subsets.
[Mh] Términos MeSH primario: Anticuerpos Neutralizantes/biosíntesis
Anticuerpos/inmunología
Anticuerpos Anti-VIH/biosíntesis
Infecciones por VIH/inmunología
VIH-1/inmunología
Memoria Inmunológica
Receptor de Muerte Celular Programada 1/inmunología
Receptores CXCR5/inmunología
Receptores CXCR/inmunología
Linfocitos T Colaboradores-Inductores/inmunología
[Mh] Términos MeSH secundario: Animales
Humanos
[Pt] Tipo de publicación:COMMENT; JOURNAL ARTICLE
[Nm] Nombre de substancia:
0 (Antibodies); 0 (Antibodies, Neutralizing); 0 (CXCR5 protein, human); 0 (CXCR7 protein, human); 0 (HIV Antibodies); 0 (PDCD1 protein, human); 0 (Programmed Cell Death 1 Receptor); 0 (Receptors, CXCR); 0 (Receptors, CXCR5)
[Em] Mes de ingreso:1312
[Cu] Fecha actualización por clase:141018
[Lr] Fecha última revisión:141018
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:131021
[St] Status:MEDLINE


  8 / 275916 MEDLINE  
              first record previous record next record last record
selecciona
para imprimir
Fotocopia
PubMed Central Texto completo
Texto completo
[PMID]:24035365
[Au] Autor:Locci M; Havenar-Daughton C; Landais E; Wu J; Kroenke MA; Arlehamn CL; Su LF; Cubas R; Davis MM; Sette A; Haddad EK; Poignard P; Crotty S; International AIDS Vaccine Initiative Protocol C Principal Investigators
[Ad] Dirección:Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA; Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.
[Ti] Título:Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses.
[So] Fuente:Immunity;39(4):758-69, 2013 Oct 17.
[Is] ISSN:1097-4180
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:The vast majority of currently licensed human vaccines work on the basis of long-term protective antibody responses. It is now conceivable that an antibody-dependent HIV vaccine might be possible, given the discovery of HIV broadly neutralizing antibodies (bnAbs) in some HIV-infected individuals. However, these antibodies are difficult to develop and have characteristics indicative of a high degree of affinity maturation in germinal centers (GCs). CD4⁺ T follicular helper (Tfh) cells are specialized for B cell help and necessary for GCs. Therefore, the development of HIV bnAbs might depend on Tfh cells. Here, we identified in normal individuals a subpopulation of circulating memory PD-1⁺CXCR5⁺CD4⁺ T cells that are resting memory cells most related to bona fide GC Tfh cells by gene expression profile, cytokine profile, and functional properties. Importantly, the frequency of these cells correlated with the development of bnAbs against HIV in a large cohort of HIV⁺ individuals.
[Mh] Términos MeSH primario: Anticuerpos Neutralizantes/biosíntesis
Anticuerpos Anti-VIH/biosíntesis
Infecciones por VIH/inmunología
VIH-1/inmunología
Receptor de Muerte Celular Programada 1/inmunología
Receptores CXCR5/inmunología
Linfocitos T Colaboradores-Inductores/inmunología
[Mh] Términos MeSH secundario: Secuencia de Aminoácidos
Linfocitos B/inmunología
Linfocitos B/patología
Linfocitos B/virología
Expresión Génica
Perfilación de la Expresión Génica
Centro Germinal/inmunología
Centro Germinal/patología
Centro Germinal/virología
Infecciones por VIH/patología
Infecciones por VIH/virología
Humanos
Inmunidad Humoral
Memoria Inmunológica
Datos de Secuencia Molecular
Receptor de Muerte Celular Programada 1/genética
Receptores CXCR3/genética
Receptores CXCR3/inmunología
Receptores CXCR5/genética
Transducción de Señal
Linfocitos T Colaboradores-Inductores/patología
Linfocitos T Colaboradores-Inductores/virología
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nombre de substancia:
0 (Antibodies, Neutralizing); 0 (CXCR3 protein, human); 0 (CXCR5 protein, human); 0 (HIV Antibodies); 0 (PDCD1 protein, human); 0 (Programmed Cell Death 1 Receptor); 0 (Receptors, CXCR3); 0 (Receptors, CXCR5)
[Em] Mes de ingreso:1312
[Cu] Fecha actualización por clase:141018
[Lr] Fecha última revisión:141018
[Sb] Subgrupo de revista:IM
[Da] Fecha de ingreso para procesamiento:131021
[St] Status:MEDLINE


  9 / 275916 MEDLINE  
              first record previous record next record last record
selecciona
para imprimir
Fotocopia
PubMed Central Texto completo
Texto completo
[PMID]:23808487
[Au] Autor:Bott S; Obermeyer CM
[Ad] Dirección:Center for Research on Population and Health, Faculty of Health Sciences of American University of Beirut.
[Ti] Título:The social and gender context of HIV disclosure in sub-Saharan Africa: a review of policies and practices.
[So] Fuente:SAHARA J;10 Suppl 1:S5-16, 2013 Jul.
[Is] ISSN:1813-4424
[Cp] País de publicación:South Africa
[La] Idioma:eng
[Ab] Resumen:This paper reviews the legal and policy context of HIV disclosure in sub-Saharan Africa, as well as what is known about rates, consequences and social context of disclosure, with special attention to gender issues and the role of health services. Persistent rates of nondisclosure by those diagnosed with HIV raise difficult ethical, public health and human rights questions about how to protect the medical confidentiality, health and well-being of people living with HIV on the one hand, and how to protect partners and children from HIV transmission on the other. Both globally and within the sub-Saharan African region, a spate of recent laws, policies and programmes have tried to encourage or - in some cases - mandate HIV disclosure. These policies have generated ethical and policy debates. While there is consensus that the criminalization of transmission and nondisclosure undermines rights while serving little public health benefit, there is less clarity about the ethics of third party notification, especially in resource-constrained settings. Despite initiatives to encourage voluntary HIV disclosure and to increase partner testing in sub-Saharan Africa, health workers continue to grapple with difficult challenges in the face of nondisclosure, and often express a need for more guidance and support in this area. A large body of research indicates that gender issues are key to HIV disclosure in the region, and must be considered within policies and programmes. Taken as a whole, this evidence suggests a need for more attention to the challenges and dilemmas faced by both clients and providers in relation to HIV disclosure in this region and for continued efforts to consider the perspectives and rights of all those affected.
[Mh] Términos MeSH primario: Actitud Frente a la Salud
Infecciones por VIH/psicología
Relaciones Interpersonales
Relaciones Profesional-Paciente
Política Social
Revelación de la Verdad
[Mh] Términos MeSH secundario: Serodiagnóstico del SIDA
África del Sur del Sahara/epidemiología
Terapia Antirretroviral Altamente Activa
Confidencialidad/ética
Confidencialidad/legislación & jurisprudencia
Crimen/legislación & jurisprudencia
Notificación de Enfermedad/legislación & jurisprudencia
Deber de Advertencia
Familia
Femenino
Adhesión a Directriz
Guías como Asunto
Infecciones por VIH/quimioterapia
Infecciones por VIH/epidemiología
Infecciones por VIH/prevención & control
Humanos
Masculino
Derechos del Paciente/legislación & jurisprudencia
Exámenes Prenupciales/economía
Autorrevelación
Parejas Sexuales
Estigma Social
Factores Socioeconómicos
Revelación de la Verdad/ética
[Pt] Tipo de publicación:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; REVIEW
[Em] Mes de ingreso:1403
[Cu] Fecha actualización por clase:141018
[Lr] Fecha última revisión:141018
[Sb] Subgrupo de revista:IM; X
[Da] Fecha de ingreso para procesamiento:130712
[St] Status:MEDLINE
[do] DOI:10.1080/02664763.2012.755319


  10 / 275916 MEDLINE  
              first record previous record
selecciona
para imprimir
Fotocopia
PubMed Central Texto completo
Texto completo
[PMID]:23698562
[Au] Autor:Sabin CA; Lundgren JD
[Ad] Dirección:Research Department of Infection and Population Health, University College London (UCL), Royal Free Campus, London, UK.
[Ti] Título:The natural history of HIV infection.
[So] Fuente:Curr Opin HIV AIDS;8(4):311-7, 2013 Jul.
[Is] ISSN:1746-6318
[Cp] País de publicación:United States
[La] Idioma:eng
[Ab] Resumen:PURPOSE OF REVIEW: To review recent published literature around three areas: long-term nonprogression/viral control; predictors of viral load set point/disease progression; and the potential impact of antiretroviral therapy (ART) in early HIV infection. RECENT FINDINGS: The natural course of untreated HIV infection varies widely with some HIV-positive individuals able to maintain high CD4 cell counts and/or suppressed viral load in the absence of ART. Although similar, the underlying mechanistic processes leading to long-term nonprogression and viral control are likely to differ. Concerted ongoing research efforts will hopefully identify host factors that are causally related to these phenotypes, thus providing opportunities for the development of novel treatment or preventive strategies. Although there is increasing evidence that initiation of ART during primary infection may prevent the immunological deterioration which would otherwise be seen in untreated HIV infection, recent studies do not address the longer term clinical benefits of ART at this very early stage. SUMMARY: A better understanding of the relative influences of viral, host, and environmental factors on the natural course of HIV infection has the potential to identify novel targets for intervention to prevent and treat HIV-infected persons.
[Mh] Términos MeSH primario: Infecciones por VIH/patología
[Mh] Términos MeSH secundario: Antirretrovirales/uso terapéutico
Progresión de la Enfermedad
Infecciones por VIH/quimioterapia
Infecciones por VIH/inmunología
Infecciones por VIH/virología
Humanos
[Pt] Tipo de publicación:JOURNAL ARTICLE; REVIEW
[Nm] Nombre de substancia:
0 (Anti-Retroviral Agents)
[Em] Mes de ingreso:1312
[Cu] Fecha actualización por clase:141018
[Lr] Fecha última revisión:141018
[Sb] Subgrupo de revista:IM; X
[Da] Fecha de ingreso para procesamiento:130607
[St] Status:MEDLINE
[do] DOI:10.1097/COH.0b013e328361fa66



página 1 de 27592 va a la página                         
   


Refinar la búsqueda
  Base de datos : MEDLINE Formulario avanzado   

    Buscar en el campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPS/OMS - Centro Latinoamericano y del Caribe de Información en Ciencias de la Salud