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[PMID]: 24688446 [Au] Autor: Agrafiotis M; Keklikoglou I; Papoti S; Diminikos G; Diplaris K; Michaelidis V [Ad] Dirección: 2nd Department of Intensive Care Medicine, "G. Papanikolaou" General Hospital of Thessaloniki, G. Papanikolaou Avenue, Exohi, 57010 Thessaloniki, Greece.... [Ti] Título: Effect of the independent Acid base variables on anion gap variation in cardiac surgical patients: a stewart-figge approach. [So] Fuente: ScientificWorldJournal;2014:907521, 2014. [Is] ISSN: 1537-744X [Cp] País de publicación: England [La] Idioma: eng [Ab] Resumen: Purpose. To determine the effect of each of independent acid base variables on the anion gap (AG) value in cardiac surgical patients. Methods. This retrospective study involved 128 cardiac surgical patients admitted for postoperative care. The variation of AG (AGvar) between the day of admission and the first postoperative day was correlated via a multiple linear regression model with the respective variations of the independent acid base variables, that is, apparent strong ion difference (SIDa), strong ion gap (SIG), carbon dioxide (PCO2), and albumin and phosphate concentrations. Results. The variations of all the above variables contributed significantly to the prediction of AGvar (adjusted R (2) = 0.9999, F = 201890.24, and P < 0.001). According to the standardized coefficients ( ß ), SIGvar ( ß = 0.948, P < 0.001), [Albumin]var ( ß = 0.260, P < 0.001), and [Phosphate]var ( ß = 0.191, P < 0.001) were the major determinants of AGvar with lesser contributions from SIDa, var ( ß = 0.071, P < 0.001) and PCO2, var ( ß = -0.067, P < 0.001). Conclusions. All the independent acid base variables contribute to the prediction of the AG value. However, albumin and phosphate and SIG variations seem to be the most important predictors, while AG appears to be rather stable with changes in PCO2 and SIDa. [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1404 [Sb] Subgrupo de revista: IM [St] Status: In-Data-Review [do] DOI: 10.1155/2014/907521

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[PMID]: 24685207 [Au] Autor: Goujon C [Ad] Dirección: Infectious Diseases Department, King's College London, School of Medicine, 2nd floor Borough Wing, Guy's Hospital, SE1 3LH Londres, Royaume-Uni. [Ti] Título: [Human MX2 is an effector of IFN-mediated resistance to HIV-1 infection]. [Ti] Título: La protéine MX2 humaine est l'un des acteurs de la réponse interféron contre le VIH-1.. [So] Fuente: Med Sci (Paris);30(3):233-5, 2014 Mar. [Is] ISSN: 0767-0974 [Cp] País de publicación: France [La] Idioma: fre [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1404 [Sb] Subgrupo de revista: IM [St] Status: In-Data-Review [do] DOI: 10.1051/medsci/20143003004

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[PMID]: 24490904 [Au] Autor: Frederick RE; Ojha S; Lamb A; Dubois JL [Ad] Dirección: Department of Chemistry and Biochemistry, University of Notre Dame , Notre Dame, Indiana 46556, United States. [Ti] Título: How pH Modulates the Reactivity and Selectivity of a Siderophore-Associated Flavin Monooxygenase. [So] Fuente: Biochemistry;53(12):2007-16, 2014 Apr 1. [Is] ISSN: 1520-4995 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: Flavin-containing monooxygenases (FMOs) catalyze the oxygenation of diverse organic molecules using O2, NADPH, and the flavin adenine dinucleotide (FAD) cofactor. The fungal FMO SidA initiates peptidic siderophore biosynthesis via the highly selective hydroxylation of l-ornithine, while the related amino acid l-lysine is a potent effector of reaction uncoupling to generate H2O2. We hypothesized that protonation states could critically influence both substrate-selective hydroxylation and H2O2 release, and therefore undertook a study of SidA's pH-dependent reaction kinetics. Consistent with other FMOs that stabilize a C4a-OO(H) intermediate, SidA's reductive half reaction is pH independent. The rate constant for the formation of the reactive C4a-OO(H) intermediate from reduced SidA and O2 is likewise independent of pH. However, the rate constants for C4a-OO(H) reactions, either to eliminate H2O2 or to hydroxylate l-Orn, were strongly pH-dependent and influenced by the nature of the bound amino acid. Solvent kinetic isotope effects of 6.6 ± 0.3 and 1.9 ± 0.2 were measured for the C4a-OOH/H2O2 conversion in the presence and absence of l-Lys, respectively. A model is proposed in which l-Lys accelerates H2O2 release via an acid-base mechanism and where side-chain position determines whether H2O2 or the hydroxylation product is observed. [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1404 [Sb] Subgrupo de revista: IM [St] Status: In-Data-Review [do] DOI: 10.1021/bi401256b

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[PMID]: 24640127 [Au] Autor: Davis NA; Giiasov KhZ; Islamova ZhI; Tuichiev LN; Parpieva NN; Belotserkovets VG; Dzhuraeva ZB; Syrov VN; Faizullaeva DB; Papina ES; Baimbetov BN; Osipova SO [Ti] Título: [Evaluation of the efficacy of antiparasitic drugs in the treatment of concurrent parasitic diseases in patients with HIV infection and in those with pulmonary tuberculosis]. [So] Fuente: Med Parazitol (Mosk);(4):24-7, 2013 Oct-Dec. [Is] ISSN: 0025-8326 [Cp] País de publicación: Russia (Federation) [La] Idioma: rus [Ab] Resumen: The efficacy of albendazole (400 mg taken once), mebendazole (100 mg taken once), and metronidazole (0.5 g thrice daily for 7 days) was evaluated when treating ascariasis, enterobiosis, and blastocystosis, respectively, in patients with HIV infection and in those with pulmonary tuberculosis. Metronidazole-resistant lambliasis was treated with exdisten (5 mg four times for 10 days) in 30.4% of the patients with HIV infection and in 43.3% of those with tuberculosis. Most HIV infected patients received antiretroviral therapy (ARVT). All the tuberculosis patients took isoniazid, ethambutol, pyrazinamide, rifampicin, and streptomycin. Efficiency was monitored by triple coproscopy at an interval of 5-7 days and by additional examinations using the method of Ritchii et al. There was parasitological cure (decreased infection rate for blastocystosis) and clinical improvement as positive changes in symptoms, such as nausea, weakness, headache, weight loss, and others, in all the patients with concomitant ascariasis, enterobiosis, and lambliasis. ARVT and antituberculosis drugs were observed to be better tolerated in all cases. [Mh] Términos MeSH primario: Antiparasitarios/uso terapéutico Infecciones por VIH/complicaciones Parasitosis Intestinales/quimioterapia Tuberculosis Pulmonar/complicaciones [Mh] Términos MeSH secundario: Adolescente Adulto Anciano Albendazol/uso terapéutico Fármacos Anti-VIH/uso terapéutico Antituberculosos/uso terapéutico Ascariasis/complicaciones Ascariasis/quimioterapia Ascariasis/parasitología Infecciones por Blastocystis/complicaciones Infecciones por Blastocystis/quimioterapia Infecciones por Blastocystis/parasitología Enterobiasis/complicaciones Enterobiasis/quimioterapia Enterobiasis/parasitología Heces/parasitología Femenino Giardiasis/complicaciones Giardiasis/quimioterapia Giardiasis/parasitología Infecciones por VIH/quimioterapia Infecciones por VIH/virología Humanos Parasitosis Intestinales/complicaciones Parasitosis Intestinales/parasitología Masculino Mebendazol/uso terapéutico Metronidazol/uso terapéutico Mediana Edad Resultado del Tratamiento Tuberculosis Pulmonar/quimioterapia Tuberculosis Pulmonar/microbiología [Pt] Tipo de publicación: ENGLISH ABSTRACT; JOURNAL ARTICLE [Nm] Nombre de substancia: 0 (Anti-HIV Agents); 0 (Antiparasitic Agents); 0 (Antitubercular Agents); 140QMO216E (Metronidazole); 81G6I5V05I (Mebendazole); F4216019LN (Albendazole) [Em] Mes de ingreso: 1404 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 140319 [St] Status: MEDLINE

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[PMID]: 24567985 [Au] Autor: Iwelunmor J; Airhihenbuwa CO [Ad] Dirección: Department of Biobehavioral Health, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. jia111@psu.edu [Ti] Título: Cultural implications of death and loss from AIDS among women in South Africa. [So] Fuente: Death Stud;36(2):134-51, 2012 Feb. [Is] ISSN: 0748-1187 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: Over 1.8 million people have died of AIDS in South Africa, and it continues to be a death sentence for many women. The purpose of this study was to examine the broader context of death and loss from HIV/AIDS and to identify the cultural factors that influenced existing beliefs and attitudes. The participants included 110 women recruited from 3 communities in South Africa. Focus group methodology was used to explore their perceptions surrounding death and loss from HIV/AIDS. Using the PEN-3 cultural model, our findings revealed that there were positive perceptions related to how women cope and respond to death and loss from HIV/AIDS. Findings also revealed existential responses and negative perceptions that strongly influence how women make sense of increasing death and loss from HIV/AIDS. In the advent of rising death and loss from HIV/AIDS, particularly among women, interventions aimed at reducing negative perceptions while increasing positive and existential perceptions are needed. These interventions should be tailored to reflect the cultural factors associated with HIV/AIDS. [Mh] Términos MeSH primario: Síndrome de Inmunodeficiencia Adquirida/etnología Síndrome de Inmunodeficiencia Adquirida/psicología Actitud Frente a la Muerte Aflicción Características Culturales Países en Desarrollo Identidad de Género Seropositividad para VIH/etnología Seropositividad para VIH/psicología [Mh] Términos MeSH secundario: Síndrome de Inmunodeficiencia Adquirida/mortalidad Adaptación Psicológica Cuidadores/psicología Causas de Muerte Estudios Transversales Existencialismo Femenino Grupos Focales Seropositividad para VIH/mortalidad Humanos Modelos Psicológicos Rol del Enfermo Estigma Social Sudáfrica [Pt] Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL [Em] Mes de ingreso: 1404 [Sb] Subgrupo de revista: T [Da] Fecha de ingreso para procesamiento: 140225 [St] Status: MEDLINE

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[PMID]: 24563943 [Au] Autor: Miller AK; Lee BL; Henderson CE [Ad] Dirección: Department of Psychology and Philosophy, Sam Houston State University, Huntsville, Texas 77341, USA. audrey.k.miller@shsu.edu [Ti] Título: Death anxiety in persons with HIV/AIDS: a systematic review and meta-analysis. [So] Fuente: Death Stud;36(7):640-63, 2012 Aug. [Is] ISSN: 0748-1187 [Cp] País de publicación: United States [La] Idioma: eng [Ab] Resumen: One of the most commonly cited psychological sequelae of HIV/AIDS is anxiety regarding death due to the illness (i.e., death anxiety; DA). However, extant research is inconclusive on several empirical issues, such as DA's relation to HIV/AIDS diagnostic status, the impact of illness-related symptoms on DA, and factors that may protect against DA. We conducted a systematic review of the empirical literature and meta-analysis to answer specific questions concerning correlates of DA in persons with HIV/AIDS and important factors that may help explain variability in effect size estimates. The meta-analysis included 18 studies (N = 1,757) examining DA in adults with HIV/AIDS. Meta-analytic findings indicated a small-to-medium effect of HIV/AIDS diagnostic status on DA, which was moderated by duration since diagnosis and by relation to the advent of highly active antiretroviral therapy. Results also indicated a small effect of illness-related symptoms on DA, which was moderated by participant age. Social support and intrinsic religiosity were modest protective factors, but results indicated that extrinsic religiosity may exacerbate or be exacerbated by DA. Finally, results indicated a medium-to-large relation between psychological symptoms and DA. The implications of these results and other study findings are discussed. [Mh] Términos MeSH primario: Ansiedad/psicología Actitud Frente a la Muerte Infecciones por VIH/psicología [Mh] Términos MeSH secundario: Humanos [Pt] Tipo de publicación: JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW [Em] Mes de ingreso: 1404 [Sb] Subgrupo de revista: T [Da] Fecha de ingreso para procesamiento: 140224 [St] Status: MEDLINE

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[PMID]: 24531178 [Au] Autor: Fantauzzi A; Digiulio MA; Cavallari EN; d'Ettorre G; Vullo V; Mezzaroma I [Ad] Dirección: Department of Clinical Medicine, Sapienza, University of Rome, Italy. [Ti] Título: Guillain Barre syndrome in an HIV-1-infected patient after the beginning of combined antiretroviral therapy: an immune reconstitution inflammatory syndrome? [So] Fuente: New Microbiol;37(1):103-7, 2014 Jan. [Is] ISSN: 1121-7138 [Cp] País de publicación: Italy [La] Idioma: eng [Ab] Resumen: HIV-1-associated Guillan-Barre syndrome (hGBS) is an ascendant progressive polyradiculoneuropathy described throughout the course of the viral disease, mainly associated with the acute retroviral syndrome. HGBS is occasionally described in severely immunocompromised subjects in the context of the immune reconstitution inflammatory syndrome. The case described occurred soon after the start of a combined antiretroviral treatment in an HIV-1 infected patient with ulcerative colitis in the absence of severe immunosuppression. This manifestation may be interpreted as an uncommon appearance of an immune reconstitution syndrome in the presence of a predisposing autoimmune pathology. [Mh] Términos MeSH primario: Terapia Antirretroviral Altamente Activa/efectos adversos Síndrome de Guillain-Barre/etiología Infecciones por VIH/quimioterapia Síndrome Inflamatorio de Reconstitución Inmune/etiología [Mh] Términos MeSH secundario: Adulto Síndrome de Guillain-Barre/inmunología Infecciones por VIH/complicaciones Infecciones por VIH/inmunología VIH-1 Humanos Síndrome Inflamatorio de Reconstitución Inmune/inmunología Masculino [Pt] Tipo de publicación: CASE REPORTS; JOURNAL ARTICLE [Em] Mes de ingreso: 1404 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 140217 [St] Status: MEDLINE

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[PMID]: 24531173 [Au] Autor: Fogli M; Iaria M; Focá E; Giagulli C; Caccuri F; Maggi F; Torti C; Caruso A; Fiorentini S [Ad] Dirección: Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia, Piazzale Spedali Civili, Brescia, Italy. [Ti] Título: For timing of HAART is less more? CD4+/CD8+ ratio and CD4+ percentage as surrogate markers for more complex immunological features. [So] Fuente: New Microbiol;37(1):75-80, 2014 Jan. [Is] ISSN: 1121-7138 [Cp] País de publicación: Italy [La] Idioma: eng [Ab] Resumen: There is disagreement on the optimal timing of HAART initiation based on absolute CD4+ T-cell count (CD4+ count). We investigated if na�ve patients with CD4+ T-cell percentage (%CD4+) <29% or CD4+/CD8+ ratio <1 display signs of immune deterioration notwithstanding CD4+ count ?500 cells/?l. We found that these patients show B-cell aberrations and an impaired control of Torque Teno Virus replication. By contrast, patients with CD4+?500/?l, %CD4+?29% and CD4+/CD8+?1 displayed features of healthy subjects. Results obtained suggest that a combination of these parameters could be an adequate surrogate marker of immunological competence. This will be helpful in deciding when to start HAART. [Mh] Términos MeSH primario: Marcadores Biológicos/sangre Infecciones por VIH/quimioterapia Infecciones por VIH/inmunología [Mh] Términos MeSH secundario: Adulto Fármacos Anti-VIH/uso terapéutico Terapia Antirretroviral Altamente Activa Relación CD4-CD8 Femenino Infecciones por VIH/sangre VIH-1 Humanos Recuento de Linfocitos Masculino Mediana Edad Adulto Joven [Pt] Tipo de publicación: JOURNAL ARTICLE [Nm] Nombre de substancia: 0 (Anti-HIV Agents); 0 (Biological Markers) [Em] Mes de ingreso: 1404 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 140217 [St] Status: MEDLINE

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[PMID]: 24531168 [Au] Autor: Borderi M; Calza L; Colangeli V; Vanino E; Viale P; Gibellini D; Re MC [Ad] Dirección: Infectious Disease Unit, Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy. [Ti] Título: Prevalence of sub-clinical vertebral fractures in HIV-infected patients. [So] Fuente: New Microbiol;37(1):25-32, 2014 Jan. [Is] ISSN: 1121-7138 [Cp] País de publicación: Italy [La] Idioma: eng [Ab] Resumen: Although the increased prevalence of low bone mineral density among HIV-infected patients has raised concern for increased fracture risk, few investigations have evaluated fracture rates. Increasing evidence indicates that HIV patients are at higher risk of osteoporotic fractures compared to the general population. This is a very important issue, because fragility fractures are complications with a significant prognostic value. Our study performed lateral spine X-ray to assess the prevalence of sub-clinical vertebral fractures in 202 HIV patients. Factors associated with vertebral fractures were also investigated. The prevalence of vertebral fractures was significantly high (23.3%): 14 subjects had SDI (spine deformity index)= 1, 22 SDI=2-3 and 11 SDI >4. Differences in the prevalence of vertebral fractures between naive and ART experienced patients was 18% vs. 24%, respectively. Furthermore, patients had a high prevalence of severe and multiple fractures; in 19 patients (40%) fractures involved multiple vertebrae. Patients with vertebral fractures were significantly older, with renal insufficiency and steroid use more frequently than subjects with no fractures. Our data suggest that the prevalence of vertebral fractures in HIV infection may be higher than expected, and lateral spine X-ray has a role in the screening of bone disease, at least in patients with a significant risk of fragility fractures. [Mh] Términos MeSH primario: Infecciones por VIH/complicaciones Fracturas de la Columna Vertebral/epidemiología Fracturas de la Columna Vertebral/etiología [Mh] Términos MeSH secundario: Adulto Anciano Densidad Ósea Estudios Transversales Femenino Infecciones por VIH/fisiopatología Humanos Masculino Mediana Edad Prevalencia Factores de Riesgo Fracturas de la Columna Vertebral/radiografía Columna Vertebral/radiografía [Pt] Tipo de publicación: JOURNAL ARTICLE [Em] Mes de ingreso: 1404 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 140217 [St] Status: MEDLINE

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[PMID]: 24522309 [Au] Autor: Peña A; Cerón I; Budnik I; Barttlet D; Cataldo K; Fernández AM; Ramírez A; Lasso M [Ti] Título: [Prevention of vertical transmission and side effects of antiretroviral therapy in children born to HIV-positive South Eastern area of Santiago, Chile: 15-years perspective]. [Ti] Título: Prevención de la transmisión vertical y efectos secundarios de la terapia anti-retroviral en hijos nacidos de madres seropositivas para VIH en el área Sur-Oriente de Santiago, Chile: perspectiva de 15 años.. [So] Fuente: Rev Chilena Infectol;30(6):644-52, 2013 Dec. [Is] ISSN: 0716-1018 [Cp] País de publicación: Chile [La] Idioma: spa [Ab] Resumen: Antiretroviral therapy (ART) has shown to be an effective measure in decreasing HIV vertical transmission (VT). Nevertheless, it is not free from adverse effects in the newborn: risk of prematurity, low birth weight, metabolic disorders, among others. Despite the importance of the subject, there are few national data that analyze the problem. We performed a retrospective analysis of a cohort of HIV positive mother/child binomial, followed between 1995 and 2010. Ninety-four pregnancies and 96 children (2 twin pregnancies) were analyzed. The rate of VT was 2.1%. Adverse effects attributed to ART were found on 85.4% of the newborn; highlighting the presence of anemia (70.8%) and several metabolic disorders [elevated lactate without acidosis (29.2%), lactic acidosis (12.5%), hyperkalemia (14.6%), metabolic acidosis (9.4%)]. Maternal exposure to protease inhibitors proved to be an independent risk factor for the development of metabolic disorders in newborns (OR 0.15 [0.04-0.48], p < 0.01). In our series, ART was effective in reducing the VT, however exposed newborns showed a high frequency of adverse effects, so it is advisable to implement programs for monitoring these patients to prevent sequelae. [Mh] Términos MeSH primario: Fármacos Anti-VIH/efectos adversos Infecciones por VIH/transmisión Transmisión Vertical de Enfermedad Infecciosa/prevención & control Complicaciones Infecciosas del Embarazo/quimioterapia [Mh] Términos MeSH secundario: Chile/epidemiología Femenino Infecciones por VIH/epidemiología Humanos Recién Nacido Transmisión Vertical de Enfermedad Infecciosa/estadística & datos numéricos Embarazo Complicaciones Infecciosas del Embarazo/epidemiología Estudios Retrospectivos Factores de Riesgo [Pt] Tipo de publicación: ENGLISH ABSTRACT; JOURNAL ARTICLE; OBSERVATIONAL STUDY [Nm] Nombre de substancia: 0 (Anti-HIV Agents) [Em] Mes de ingreso: 1404 [Sb] Subgrupo de revista: IM [Da] Fecha de ingreso para procesamiento: 140213 [St] Status: MEDLINE

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