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Search on : Acanthopanax [Words]
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[PMID]: 29459269
[Au] Autor:Bian X; Liu X; Liu J; Zhao Y; Li H; Cai E; Li P; Gao Y
[Ad] Address:College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
[Ti] Title:Study on antidepressant activity of chiisanoside in mice.
[So] Source:Int Immunopharmacol;57:33-42, 2018 Feb 16.
[Is] ISSN:1878-1705
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The antidepressant-like effect of chiisanoside from the leaves of Acanthopanax sessiliflorus was evaluated by using mice models of depression, forced swim test (FST) and tail suspension test (TST). The results showed that treatment with chiisanoside at dose of 5.0 mg/kg significantly decreased immobility time in the FST and TST. Pretreatment with haloperidol (a non-selective D receptor antagonist), bicuculline (a competitive GABA antagonist) and N-methyl-D-aspartic acid (NMDA, an agonist at the glutamate site) effectively reversed the antidepressant-like effect of chiisanoside (5.0 mg/kg). Moreover, chiisanoside treatment did not change the locomotor activity. And chiisanoside (5.0 mg/kg) also effectively increased the dopamine (DA) and γ-aminobutyric acid (GABA) levels in mice brains exposed to the FST and TST in the co-treatment groups. Then we designed lipopolysaccharide (LPS)-induced antidepressant behavioral experiment, the results showed that LPS significantly increased immobility duration in the TST and FST. Chiisanoside administration could effectively reduce serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels; at the same time, the changes of related indexes of oxidative stress are improved, such as superoxide dismutase (SOD) and malondialdehyde (MDA). Moreover, chiisanoside effectively down-regulated brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB) and nuclear factor-κB (NF-κB) in hippocampal. In conclusion, chiisanoside displayed significant antidepressant-like effect, which was probably related to the DAergic, GABAergic and glutamatergic systems. And the mechanism of anti-depressant effect of chiisanoside might be via the alterations of animal behaviors, hippocampus inflammation, oxidative stress and neurotrophy, which might be attributed by the BDNF/TrkB/NF-κB pathway.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[St] Status:Publisher

  2 / 593 MEDLINE  
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[PMID]: 29342911
[Au] Autor:Zhou Y; Cheng C; Baranenko D; Wang J; Li Y; Lu W
[Ad] Address:Institute of Extreme Environment Nutrition and Protection, Harbin Institute of Technology, Harbin 150001, China. zhouyingyu_work@outlook.com.
[Ti] Title:Effects of Acanthopanax senticosus on Brain Injury Induced by Simulated Spatial Radiation in Mouse Model Based on Pharmacokinetics and Comparative Proteomics.
[So] Source:Int J Mol Sci;19(1), 2018 Jan 15.
[Is] ISSN:1422-0067
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:The active compounds in (AS) have different pharmacokinetic characteristics in mouse models. C and AUC of (ASPS) were significantly reduced in radiation-injured mice, suggesting that the blood flow of mouse was blocked or slowed, due to the pathological state of ischemia and hypoxia, which are caused by radiation. In contrast, the ability of various metabolizing enzymes to inactivate, capacity of biofilm transport decrease, and lessening of renal blood flow accounts for radiation, resulting in the accumulation of syringin and eleutheroside E in the irradiated mouse. Therefore, there were higher pharmacokinetic parameters-AUC, MRT, and t of the two compounds in radiation-injured mouse, when compared with normal mouse. In order to investigate the intrinsic mechanism of AS on radiation injury, AS extract's protective effects on brain, the main part of mouse that suffered from radiation, were explored. The function of AS extract in repressing expression changes of radiation response proteins in prefrontal cortex (PFC) of mouse brain included tubulin protein family (α-, -tubulin subunits), dihydropyrimidinase-related protein 2 (CRMP2), γ-actin, 14-3-3 protein family (14-3-3ζ, ε), heat shock protein 90 (HSP90), and enolase 2. The results demonstrated the AS extract had positive effects on nerve cells' structure, adhesion, locomotion, fission, and phagocytosis, through regulating various action pathways, such as Hippo, phagosome, PI3K/Akt (phosphatidylinositol 3 kinase/protein kinase B), Neurotrophin, Rap1 (Ras-related protein RAP-1A), gap junction glycolysis/gluconeogenesis, and HIF-1 (Hypoxia-inducible factor 1) signaling pathways to maintain normal mouse neurological activity. All of the results indicated that AS may be a promising alternative medicine for the treatment of radiation injury in mouse brain. It would be tested that whether the bioactive ingredients of AS could be effective through the blood-brain barrier in the future.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:In-Process

  3 / 593 MEDLINE  
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[PMID]: 29301264
[Au] Autor:Li XJ; Zou QP; Wang X; Kim KW; Lu MF; Ko SK; Yook CS; Kim YC; Liu XQ
[Ad] Address:School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China. lixiaojun2017@yahoo.com.
[Ti] Title:Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus.
[So] Source:Molecules;23(1), 2018 Jan 01.
[Is] ISSN:1420-3049
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:The phytochemical study on the leaves of (Araliaceae) resulted in the discovery of a new lupane-triterpene compound, acangraciligenin S ( ), and a new lupane-triterpene glycoside, acangraciliside S ( ), as well as two known ones, 3α,11α-dihydroxy-lup-20(29)-en-23,28-dioic acid ( ) and acankoreoside C ( ). Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. The chemical structures of the new compounds and were determined to be 1,3α-dihydroxy-lup-20(29)-en-23, 28-dioic acid and 1,3α-dihydroxy-lup-20(29)-en-23,28-dioic acid 28- -[α-l-rhamnopyranosyl-(1→4)--d-glucopyranosyl-(1→6)--d-glucopyranosyl] ester, respectively. The anti-neuroinflammatory activity of the selective compounds, and , were evaluated with lipopolysaccharide (LPS)-induced BV2 microglia. The tested compounds showed moderate inhibitory effect of nitric oxide (NO) production.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180105
[Lr] Last revision date:180105
[St] Status:In-Process

  4 / 593 MEDLINE  
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[PMID]: 29128601
[Au] Autor:Hu HB; Liang HP; Li HM; Yuan RN; Sun J; Zhang LL; Han MH; Wu Y
[Ad] Address:College of Chemistry & Chemical Engineering, Longdong University, Qingyang 745000, PR China. Electronic address: hhb-88@126.com.
[Ti] Title:Isolation, modification and cytotoxic evaluation of stilbenoids from Acanthopanax leucorrhizus.
[So] Source:Fitoterapia;, 2017 Nov 08.
[Is] ISSN:1873-6971
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Twenty natural stilbenoids (1-20), including seven new stilbenoids (2, 4-7, 19, 20) and thirteen known stilbenoids (1, 3, 8-18), were isolated from the stem barks of Acanthopanax leucorrhizus, and six modified stilbenoid derivatives (1a, 2a, 4a, 4b, 7a and 17a) were obtained via methylation, demethylation and isopentenylation of the corresponding isolates (1, 2, 4, 7 and 17). These stilbenoids were structurally characterized by comprehensive analysis of their spectroscopic data and comparison with literature information, and evaluated for their cytotoxic activities against three human tumor cell lines (leukemia HL-60, hepatoma SMMC-7721 and breast carcinoma MCF-7) in vitro by MTT assay. The results showed that compounds 1a, 4a and 4b showed potent selective cytotoxicity against SMMC-7721 (IC =10.161.95M and 9.761.32M) and MCF-7 (IC =10.722.78M) cell lines. The cytotoxic evaluation of these structurally modified stilbenoid derivatives have led to the establishment of a structure-activity relationship.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171112
[Lr] Last revision date:171112
[St] Status:Publisher

  5 / 593 MEDLINE  
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[PMID]: 29039503
[Au] Autor:Zou QP; Liu XQ; Huang JJ; Yook CS; Whang WK; Lee HK; Kwon OK
[Ad] Address:Changsha BroadOcean BioScience and Technique Co., Ltd., Changsha, Hunan 410205, P.R. China.
[Ti] Title:Inhibitory effects of lupanetype triterpenoid saponins from the leaves of Acanthopanaxgracilistylus on lipopolysaccharide-induced TNFα, IL1 and highmobility group box 1 release in macrophages.
[So] Source:Mol Med Rep;16(6):9149-9156, 2017 Dec.
[Is] ISSN:1791-3004
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:Acanthopanaxgracilistylus (AGS) has long been used in traditional Chinese medicine for the treatment of various inflammatory diseases. 3O߭Dglucopyranosyl 3α, 11αdihydroxylup20(29)en28oic acid, acantrifoside A, acankoreoside D, acankoreoside B and acankoreoside A are major lupanetype triterpenoid saponins derived from AGS. In the present study, these five saponins were isolated from AGS by chromatography and their antiinflammatory activities were investigated in lipopolysaccharide (LPS)treated RAW264.7 macrophages. Cell viability was evaluated by MTT assay. Tumor necrosis factor (TNF)α, interleukin (IL)1 and NFκB p65 were measured by ELISA. The gene expression levels of TNFα and IL1 was detected by reversetranscription polymerase chain reaction. And highmobility group box 1 (HMGB1) were analyzed by western blotting. The results demonstrated that these five saponins significantly suppressed LPSinduced expression of TNFα and IL1 at the mRNA and protein level in RAW264.7 cells. Further analysis revealed that acankoreoside A and acankoreoside B were able to reduce the secretion of HMGB1 and NFκB activity induced by LPS in RAW264.7 macrophages. Taken together, these results suggested that the antiinflammatory activity of AGSderived saponins may be associated with the downregulation of TNFα and IL1, and the 'latephase' proinflammatory cytokine HMGB1, via negative regulation of the NFκB pathway in RAW264.7 cells.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171115
[Lr] Last revision date:171115
[St] Status:In-Process
[do] DOI:10.3892/mmr.2017.7767

  6 / 593 MEDLINE  
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[PMID]: 28939025
[Au] Autor:Xie XX; Jiang ZJ; Cheng ZH; Chen DF
[Ad] Address:Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China.
[Ti] Title:Preparative separation and quantitative determination of two kaurenoic acid isomers in root barks of Acanthopanax gracilistylus.
[So] Source:Chin J Nat Med;15(8):625-630, 2017 Aug.
[Is] ISSN:1875-5364
[Cp] Country of publication:China
[La] Language:eng
[Ab] Abstract:The kaurenoic acid-type diterpenoids in Acanthopanacis Cortex have been reported to be the major active components. However, the diterpenoids are present as position isomers that exacerbate the challenges in obtaining standards compounds. Little work has been done on the quantitative analysis of the diterpenoids in the herb. In the present study, two diterpenoid isomers ent-16H,17-isovalerate-kauran-19-oic acid (1) and ent-16H,17-methyl butanoate-kauran-19-oic acid (2) with high purity were separated by analytical HPLC, followed by recrystallization in acetone. Furthermore, an HPLC-ELSD method was developed and validated for simultaneous determination of 1 and 2 in 9 batches of Acanthopanacis Cortex samples. The HPLC separation and quantification was achieved in 40 min using an Agela Promosil C column eluted with a gradient of water and acetonitrile. The calibration curves showed good linearity (r ≥ 0.999 9) within the test ranges. The LOD ranged from 0.407 2 to 0.518 0 g and LOQ ranged from 1.018 0 to 1.295 0 g. The precisions (%RSD) were within 1.47% for the two isomers. The recovery of the assay was in the range of 98.78%-99.11% with RSD values less than 2.76%. It is the first time to establish a quantitative HPLC method for the analysis of the bioactive kaurenoic acid isomers in the herb.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170923
[Lr] Last revision date:170923
[St] Status:In-Process

  7 / 593 MEDLINE  
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[PMID]: 28848992
[Au] Autor:Zhou T; Li Z; Kang OH; Mun SH; Seo YS; Kong R; Shin DW; Liu XQ; Kwon DY
[Ad] Address:Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Institute of Biotechnology, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
[Ti] Title:Antimicrobial activity and synergism of ursolic acid 3-O-α-L-arabinopyranoside with oxacillin against methicillin-resistant Staphylococcus aureus.
[So] Source:Int J Mol Med;40(4):1285-1293, 2017 Oct.
[Is] ISSN:1791-244X
[Cp] Country of publication:Greece
[La] Language:eng
[Ab] Abstract:The objective of the present study was to investigate the antibacterial activity of a single constituent, ursolic acid 3-O-α-L-arabinopyranoside (URS), isolated from the leaves of Acanthopanax henryi (Oliv.) Harms, alone and in combination with oxacillin (OXA) against methicillin-resistant Staphylococcus aureus (MRSA). A broth microdilution assay was used to determine the minimal inhibitory concentration(MIC). The synergistic effects of URS and OXA were determined using a checkerboard dilution test and time-kill curve assay. The mechanism of action of URS against MRSA was analyzed using a viability assay in the presence of a detergent and an ATPase inhibitor. Morphological changes in the URS-treated MRSA strains were evaluated via transmission electron microscopy(TEM). In addition, the producing penicillin-binding protein2a (PBP2a) protein level was analyzed using western blotting. The MIC value of URS against MRSA was found to be 6.25g/ml and there was a partial synergistic effect between OXA and URS. The time-kill growth curves were suppressed by OXA combined with URS at a sub-inhibitory level. Compared to the optical density at 600 nm (OD600) value of URS alone (0.09g/ml), the OD600 values of the suspension in the presence of 0.09g/ml URS and 0.00001% TritonX-100 or 250g/ml N,N'-dicyclohexylcarbodiimide reduced by 56.6 and 85.9%, respectively. The TEM images of MRSA indicated damage to the cell wall, broken cell membranes and cell lysis following treatment with URS and OXA. Finally, an inhibitory effect on the expression of PBP2a protein was observed when cells were treated with URS and OXA compared with untreated controls. The present study suggested that URS was significantly active against MRSA infections and revealed the potential of URS as an effective natural antibiotic.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170913
[Lr] Last revision date:170913
[St] Status:In-Process
[do] DOI:10.3892/ijmm.2017.3099

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[PMID]: 28805955
[Au] Autor:Hu HB; Liang HP; Li HM; Yuan RN; Sun J; Wu Y; Zhang LL; Han MH
[Ad] Address:College of Chemistry & Chemical Engineering, Longdong University, Qingyang, 745000, P. R. China.
[Ti] Title:Structural Modification of Stilbenoids from Acanthopanax leucorrhizus and Their Cytotoxic Activity.
[So] Source:Chem Biodivers;, 2017 Aug 14.
[Is] ISSN:1612-1880
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:A new cis-stilbenoid, 1,9-dihydroxy-10-methoxy-6H-dibenzo[b,f]oxocin-6-one (2) was isolated from the AcOEt extract of the stem barks of Acanthopanax leucorrhizus, along with three known stilbenoids, 9-hydroxy-10-methoxy-6H-dibenzo[b,f]oxocin-6-one (1), 5-O-methyl-(E)-resveratrol 3-O--d-glucopyranoside (3), and (E)-resveratrol 3-O--d-xylopyranoside (4). Two derivatives (2a and 2b) were synthesized by the structural modification of compound 2, which exhibited certain cytotoxic activities against HT-29 and HeLa cell lines invitro. All compounds were structurally characterized by comprehensive analysis of their spectroscopic data and comparison with literature information, and evaluated for their cytotoxic activities against three human tumor cell lines (HL-60, HT-29, and HeLa) by the standard MTT assay invitro. The results showed that derivatives 2a and 2b exhibited strong activities than compounds 2 against HT-29 and HeLa cell lines.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 171124
[Lr] Last revision date:171124
[St] Status:Publisher
[do] DOI:10.1002/cbdv.201700244

  9 / 593 MEDLINE  
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[PMID]: 28735730
[Au] Autor:Lim H; Min DS; Yun HE; Kim KT; Sun YN; Dat LD; Kim YH; Kim HP
[Ad] Address:College of Pharmacy, Kangwon National University, Chunchon 200-701, South Korea.
[Ti] Title:Impressic acid from Acanthopanax koreanum, possesses matrix metalloproteinase-13 down-regulating capacity and protects cartilage destruction.
[So] Source:J Ethnopharmacol;209:73-81, 2017 Sep 14.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: Acanthopanax koreanum (Araliaceae) has been used in traditional medicine for enhancing vitality, rheumatism, and bone-related pains. But its activity on cartilage protection has not been known yet. AIM OF THE STUDY: Matrix metalloproteinase (MMP)-13 has an important role in degrading cartilage materials under pathologic conditions such as arthritis. The present study was designed to find the inhibitory activity of impressic acid on MMP-13 expression and cartilage protective action. MATERIALS AND METHODS: 70% ethanol extract of Acanthopanax koreanum leaves and impressic acid, a major constituent isolated from the same plant materials, were examined on MMP-13 down-regulating capacity in IL-1-treated human chondrocyte cell line (SW1353) and rabbit cartilage explants. RESULTS: In IL-1-treated SW1353 cells, impressic acid significantly and concentration-dependently inhibited MMP-13 expression at 0.5-10M. Impressic acid was found to be able to inhibit MMP-13 expression by blocking the phosphorylation of signal transducer and activator of transcription-1/-2 (STAT-1/-2) and activation of c-Jun and c-Fos among the cellular signaling pathways involved. Further, impressic acid was found to inhibit the expression of MMP-13 mRNA (47.7% inhibition at 10M), glycosaminoglycan release (42.2% reduction at 10M) and proteoglycan loss in IL-1-treated rabbit cartilage explants culture. In addition, a total of 21 lupane-type triterpenoids structurally-related to impressic acid were isolated from the same plant materials and their suppressive activities against MMP-13 expression were also examined. Among these derivatives, compounds 2, 3, 16, and 18 clearly down-regulated MMP-13 expression. However, impressic acid was more potent than these derivatives in down-regulating MMP-13 expression. CONCLUSIONS: Impressic acid, its related triterpenoids, and A. koreanum extract have potential as therapeutic agents to prevent cartilage degradation by inhibiting matrix protein degradation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170828
[Lr] Last revision date:170828
[St] Status:In-Process

  10 / 593 MEDLINE  
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[PMID]: 28676388
[Au] Autor:Zhang L; Li BB; Li HZ; Meng X; Lin X; Jiang YY; Ahn JS; Cui L
[Ad] Address:College of Pharmacy, Beihua University, 3999 Binjiangdong Road, Jilin City, Jilin Province 132013, People's Republic of China.
[Ti] Title:Four new neolignans isolated from Eleutherococcus senticosus and their protein tyrosine phosphatase 1B inhibitory activity (PTP1B).
[So] Source:Fitoterapia;121:58-63, 2017 Sep.
[Is] ISSN:1873-6971
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Four new compounds, erythro-7'E-4-hydroxy-3,3'-dimethoxy-8,5'-oxyneoligna-7'-ene-7,9-diol-9'-al (1), (7S,8S)-4-hydroxy-3,1',3'-trimethoxy-4',7-epoxy-8,5'-neolign-9-ol (5), (7S,8S,7'E)-5-hydroxy-3,3'-dimethoxy-4',7-epoxy-8,5'-neolign-7'-ene-9,9'-diol (6) and (7S,8S,7'E)-5-hydroxy-3,3',9'-trimethoxy-4'-7-epoxy-8,5'-neolign-7'-ene-9-ol (7). Along with four known compounds (2-4, 8) were isolated from the EtOAc-soluble extract of Eleutherococcus senticosus. Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the compounds were evaluated for in vitro inhibitory activity against PTP1B, VHR and PP1. Among them, compounds 1-4 and 6-8 were found to exhibit selective inhibitory activity on PTP1B with IC values ranging from 17.21.6 to 32.71.2M.
[Mh] MeSH terms primary: Eleutherococcus/chemistry
Lignans/pharmacology
Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors
[Mh] MeSH terms secundary: Lignans/isolation & purification
Molecular Structure
Plant Stems/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Lignans); EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 1)
[Em] Entry month:1710
[Cu] Class update date: 171010
[Lr] Last revision date:171010
[Js] Journal subset:IM
[Da] Date of entry for processing:170706
[St] Status:MEDLINE


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