Database : MEDLINE Search on : Acrodynia [Words] References found : 150 [refine] Displaying: 1 .. 10   in format [Detailed]

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[PMID]: 23183295 [Au] Autor: Rosenberg IH [Ad] Address: Jean Mayer USDA Human Nutrition Research Center on Aging and Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA. irwin.rosenberg @ tufts.edu [Ti] Title: A history of the isolation and identification of vitamin B(6). [So] Source: Ann Nutr Metab;61(3):236-8, 2012. [Is] ISSN: 1421-9697 [Cp] Country of publication: Switzerland [La] Language: eng [Ab] Abstract: In the 1930s, Rudolf Peters showed that young rats kept on a semi-synthetic diet with added thiamin and riboflavin but no other supplement developed 'rat acrodynia', a condition characterized by severe cutaneous lesions. In 1934, Paul György showed that the factor which cured 'rat acrodynia' was vitamin B(6). Other studies soon showed that vitamin B(6) deficiency produced convulsions in rats, pigs, and dogs, and a microcytic anemia in certain animals. Samuel Lepkovsky isolated and crystallized vitamin B(6) in 1938. The following year, Leslie Harris and Karl Folkers, and Richard Kuhn and his associates independently showed that vitamin B(6) was a pyridine derivative, 3-hydroxy-4,5-dihydroxy-methyl-2-methyl-pyridine. György proposed the term pyridoxine for this derivative. Esmond Snell developed a microbiological growth assay in 1942 that led to the characterization of pyridoxamine, the animated product of pyridoxine, and pyridoxal, the formyl derivative of pyridoxine. Further studies showed that pyridoxal, pyridoxamine, and pyridoxine have largely equal activity in animals and owe their vitamin activity to the ability of the organism to convert them into the enzymatically active form pyridoxal-5-phosphate. Pyridoxal-5-phosphate plays a role in a wide variety of enzyme systems, especially in the metabolic utilization and transformation of amino acids. [Mh] MeSH terms primary: Vitamin B 6/chemistry Vitamin B 6/history Vitamin B 6/isolation & purification Vitamin B 6/pharmacology [Mh] MeSH terms secundary: Animals Dogs History, 20th Century Pyridoxal Phosphate/metabolism Pyridoxamine/metabolism Pyridoxine/metabolism Rats Swine Vitamin B 6 Deficiency/drug therapy Vitamin B 6 Deficiency/physiopathology Vitamins/metabolism [Pt] Publication type: HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW [Nm] Name of substance: 0 (Vitamins); 54-47-7 (Pyridoxal Phosphate); 65-23-6 (Pyridoxine); 8059-24-3 (Vitamin B 6); 85-87-0 (Pyridoxamine) [Em] Entry month: 1304 [Js] Journal subset: IM [Da] Date of entry for processing: 121127 [St] Status: MEDLINE [do] DOI: 10.1159/000343113

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[PMID]: 22498790 [Au] Autor: Yeter D; Deth R [Ad] Address: Shawnee, Kansas, USA. deniz.yeter@gmx.de [Ti] Title: ITPKC susceptibility in Kawasaki syndrome as a sensitizing factor for autoimmunity and coronary arterial wall relaxation induced by thimerosal's effects on calcium signaling via IP3. [So] Source: Autoimmun Rev;11(12):903-8, 2012 Oct. [Is] ISSN: 1873-0183 [Cp] Country of publication: Netherlands [La] Language: eng [Ab] Abstract: Recently, a single nucleotide polymorphism (SNP) of the inositol 1,4,5-triphosphate kinase C (ITPKC), rs28493229, was found to passively confer susceptibility for Kawasaki syndrome (KS) and subsequent coronary arterial lesions. This association is believed to be the result of defective phosphorylation of inositol 1,4,5-triphosphate (IP3), which releases calcium from intracellular stores, resulting from reduced genetic expression of ITPKC in carriers of the SNP. Reduced ITPKC activity would increase IP3 levels, and thus, increase calcium release. We hypothesized that an environmental agent which influences IP3-mediated calcium release is potentiated by the ITPKC SNP. This led us to an attractive candidate, thimerosal, an organomercurial medical preservative still used in several pediatric vaccines. Thimerosal is well-known to sensitize IP3 receptors via its induction of oxidative stress, resulting in enhanced release of intracellular calcium with distinctive consequences for various cell types. Dysregulated calcium signaling in T cells and other immune cells can result in autoimmunity, while hyperpolarization of vascular smooth muscle cells secondary to the stimulation of calcium-activated potassium channels can result in increased vascular permeability and arterial relaxation. We propose that ITPKC susceptibility in KS is related to its synergy with environmental triggers, such as thimerosal, which alter calcium homeostasis and promote oxidative stress. Therefore, carriers of the ITPKC SNP are more susceptible to thimerosal-induced autoimmunity and coronary arterial lesions observed in KS. This would explain why only a susceptible subset of children develops KS although pediatric thimerosal exposure is nearly universal due to vaccination. As was experienced with the infantile acrodynia epidemic, only 1 in 500 children developed the disease although pediatric mercury exposure was nearly ubiquitous due to the use calomel teething powders. This hypothesis also mirrors the current leading theory for KS in which a widespread infection only induces the disease in susceptible children. We conclude that KS may be the acute febrile form of acrodynia. [Mh] MeSH terms primary: Acrodynia/immunology Coronary Vessels/immunology Genetic Predisposition to Disease Mucocutaneous Lymph Node Syndrome/genetics Mucocutaneous Lymph Node Syndrome/immunology Phosphotransferases (Alcohol Group Acceptor)/genetics [Mh] MeSH terms secundary: Acrodynia/genetics Autoimmunity Calcium Signaling/drug effects Capillary Permeability/drug effects Child Coronary Vessels/drug effects Gene-Environment Interaction Humans Inositol 1,4,5-Trisphosphate/metabolism Oxidative Stress Polymorphism, Single Nucleotide Thimerosal/adverse effects Thimerosal/pharmacology [Pt] Publication type: JOURNAL ARTICLE; REVIEW [Nm] Name of substance: 54-64-8 (Thimerosal); 85166-31-0 (Inositol 1,4,5-Trisphosphate); EC 2.7.1.- (Phosphotransferases (Alcohol Group Acceptor)); EC 2.7.1.127 (Inositol 1,4,5-trisphosphate 3-kinase) [Em] Entry month: 1302 [Js] Journal subset: IM [Da] Date of entry for processing: 120926 [St] Status: MEDLINE

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[PMID]: 22863825 [Au] Autor: Brannan EH; Su S; Alverson BK [Ad] Address: Department of Pediatrics, Rhode Island Hospital, Providence, RI 02903, USA. [Ti] Title: Elemental mercury poisoning presenting as hypertension in a young child. [So] Source: Pediatr Emerg Care;28(8):812-4, 2012 Aug. [Is] ISSN: 1535-1815 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: Mercury intoxication is an uncommon cause of hypertension in children and can mimic several other diseases, such as pheochromocytoma and vasculitis. Mercury intoxication can present as a diagnostic challenge because levels of catecholamines may be elevated, suggesting that the etiology is a catecholamine-secreting tumor. Once acrodynia is identified as a primary symptom, a 24-hour urine mercury level can confirm the diagnosis. Inclusion of mercury intoxication in the differential diagnosis early on can help avoid unnecessary and invasive diagnostic tests and therapeutic interventions. We discuss a case of mercury intoxication in a 3-year-old girl presenting with hypertension and acrodynia, without a known history of exposure. Chelation therapy successfully treated our patient's mercury intoxication. However, it was also necessary to concurrently treat her hypertension and the pain associated with her acrodynia. Because there were no known risk factors for mercury poisoning in this case, and because ritual use of mercury is common in much of the United States, we recommend high clinical suspicion and subsequent testing in all cases of acrodynia. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1208 [Js] Journal subset: IM [St] Status: In-Process [do] DOI: 10.1097/PEC.0b013e3182628a05

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[PMID]: 22668667 [Au] Autor: French LK; Campbell J; Hendrickson RG [Ad] Address: Oregon Health & Sciences University Portland, OR, USA. [Ti] Title: A hypertensive child with irritability and a rash. [So] Source: Pediatr Emerg Care;28(6):581-3, 2012 Jun. [Is] ISSN: 1535-1815 [Cp] Country of publication: United States [La] Language: eng [Mh] MeSH terms primary: Acrodynia/complications Exanthema/etiology Hypertension/etiology Irritable Mood [Mh] MeSH terms secundary: Acrodynia/diagnosis Acrodynia/therapy Chelation Therapy Diagnosis, Differential Humans Infant Male [Pt] Publication type: CASE REPORTS; JOURNAL ARTICLE [Em] Entry month: 1210 [Js] Journal subset: IM [Da] Date of entry for processing: 120606 [St] Status: MEDLINE [do] DOI: 10.1097/PEC.0b013e318259d2d7

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[PMID]: 21803782 [Au] Autor: Sasan MS; Hadavi N; Afshari R; Mousavi SR; Alizadeh A; Balali-Mood M [Ad] Address: Department of Pediatrics, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. [Ti] Title: Metal mercury poisoning in two boys initially treated for brucellosis in Mashhad, Iran. [So] Source: Hum Exp Toxicol;31(2):193-6, 2012 Feb. [Is] ISSN: 1477-0903 [Cp] Country of publication: England [La] Language: eng [Ab] Abstract: Elemental mercury (Hg) is the only metal which evaporates in room temperature and its inhalation may cause toxicity. Hg poisoning may occur by mishandling the metal, particularly in children who play with it. Wide-spectrum of the clinical presentations of chronic Hg poisoning may cause misdiagnosis, particularly when history of exposure is unknown. We report two cases of accidental Hg poisoning, which initially had been diagnosed and treated for brucellosis. The patients were two brothers (7 and 14 years old) who presented with pain in their lower extremities, sweating, salivation, weight loss, anorexia and mood changes on admission. Meticulous history taking revealed that they had played with a ball of Hg since 3 months before admission. The level of urinary Hg was 125.9 and 54.2 9 g/L in the younger and older brother, respectively (normal ≤25 g/L). The patients were successfully treated by dimercaprol and discharged in good condition 24 days after admission. These cases are being reported to emphasize the importance of acrodynia as a differential diagnosis for brucellosis in endemic areas. [Mh] MeSH terms primary: Acrodynia/diagnosis [Mh] MeSH terms secundary: Acrodynia/drug therapy Acrodynia/urine Adolescent Brucellosis/drug therapy Chelating Agents/therapeutic use Chelation Therapy Child Diagnosis, Differential Dimercaprol/therapeutic use Humans Iran Male Mercury [Pt] Publication type: CASE REPORTS; JOURNAL ARTICLE [Nm] Name of substance: 0 (Chelating Agents); 59-52-9 (Dimercaprol); 7439-97-6 (Mercury) [Em] Entry month: 1207 [Js] Journal subset: IM [Da] Date of entry for processing: 120319 [St] Status: MEDLINE [do] DOI: 10.1177/0960327111417265

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[PMID]: 22409470 [Au] Autor: Mercer JJ; Bercovitch L; Muglia JJ [Ad] Address: Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island 02903, USA. [Ti] Title: Acrodynia and hypertension in a young girl secondary to elemental mercury toxicity acquired in the home. [So] Source: Pediatr Dermatol;29(2):199-201, 2012 Mar-Apr. [Is] ISSN: 1525-1470 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: Acrodynia, also known as pink disease, erythredema polyneuropathy, Feer syndrome, and raw-beef hands and feet, is thought to be a toxic reaction to elemental mercury and less commonly to organic and inorganic forms. Occurring commonly in the early 20th century, acrodynia is now a seemingly extinct disease in the modern world because of regulations to eliminate mercury from personal care products, household items, medications, and vaccinations. We present a case of a 3-year-old girl with acrodynia secondary to toxic exposure to elemental mercury in the home environment. [Mh] MeSH terms primary: Acrodynia/etiology Hypertension/chemically induced Mercury Poisoning/diagnosis Mercury/toxicity [Mh] MeSH terms secundary: Acrodynia/diagnosis Acrodynia/drug therapy Antihypertensive Agents/therapeutic use Chelating Agents/therapeutic use Chelation Therapy Child, Preschool Female Floors and Floorcoverings Humans Hypertension/diagnosis Hypertension/drug therapy Mercury/urine Mercury Poisoning/drug therapy Succimer/therapeutic use Treatment Outcome [Pt] Publication type: CASE REPORTS; JOURNAL ARTICLE [Nm] Name of substance: 0 (Antihypertensive Agents); 0 (Chelating Agents); 304-55-2 (Succimer); 7439-97-6 (Mercury) [Em] Entry month: 1207 [Js] Journal subset: IM [Da] Date of entry for processing: 120313 [St] Status: MEDLINE [do] DOI: 10.1111/j.1525-1470.2012.01737.x

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[PMID]: 22070717 [Au] Autor: Mahajan VK; Sharma NL [Ad] Address: Department of Dermatology, Venereology and Leprosy, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India. vkm1@rediffmail.com [Ti] Title: Metallic mercury vapour poisoning revisited. [So] Source: Australas J Dermatol;52(4):e5-7, 2011 Nov. [Is] ISSN: 1440-0960 [Cp] Country of publication: Australia [La] Language: eng [Ab] Abstract: Mercury poisoning was once common in the 19th century. With its declining use, now clinicians and the public in general are often unaware and unsuspecting of mercury toxicity. A 40-year-old woman and her two children were hospitalized with a 1-week history of a generalized lichenoid eruption. Clinical improvement occurred without a diagnosis; however, on returning home, features of acrodynia with digital gangrene developed in the woman, leading to suspicion of heavy metal poisoning. There was no recurrence after moving from their contaminated house. [Mh] MeSH terms primary: Lichenoid Eruptions/etiology Mercury Poisoning/complications Mercury Poisoning/diagnosis [Mh] MeSH terms secundary: Acrodynia/etiology Adult Child Female Fingers/pathology Gangrene/etiology Humans Male Mercury Poisoning/pathology [Pt] Publication type: CASE REPORTS; JOURNAL ARTICLE [Em] Entry month: 1204 [Js] Journal subset: IM [Da] Date of entry for processing: 111110 [St] Status: MEDLINE [do] DOI: 10.1111/j.1440-0960.2010.00679.x

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[PMID]: 21797771 [Au] Autor: Shandley K; Austin DW [Ad] Address: Swinburne Autism Bio-Research Initiative (SABRI), Brain and Psychological Sciences Research Centre, Swinburne University of Technology, Hawthorn, Victoria, Australia. [Ti] Title: Ancestry of pink disease (infantile acrodynia) identified as a risk factor for autism spectrum disorders. [So] Source: J Toxicol Environ Health A;74(18):1185-94, 2011. [Is] ISSN: 1528-7394 [Cp] Country of publication: England [La] Language: eng [Ab] Abstract: Pink disease (infantile acrodynia) was especially prevalent in the first half of the 20th century. Primarily attributed to exposure to mercury (Hg) commonly found in teething powders, the condition was developed by approximately 1 in 500 exposed children. The differential risk factor was identified as an idiosyncratic sensitivity to Hg. Autism spectrum disorders (ASD) have also been postulated to be produced by Hg. Analogous to the pink disease experience, Hg exposure is widespread yet only a fraction of exposed children develop an ASD, suggesting sensitivity to Hg may also be present in children with an ASD. The objective of this study was to test the hypothesis that individuals with a known hypersensitivity to Hg (pink disease survivors) may be more likely to have descendants with an ASD. Five hundred and twenty-two participants who had previously been diagnosed with pink disease completed a survey on the health outcomes of their descendants. The prevalence rates of ASD and a variety of other clinical conditions diagnosed in childhood (attention deficit hyperactivity disorder, epilepsy, Fragile X syndrome, and Down syndrome) were compared to well-established general population prevalence rates. The results showed the prevalence rate of ASD among the grandchildren of pink disease survivors (1 in 22) to be significantly higher than the comparable general population prevalence rate (1 in 160). The results support the hypothesis that Hg sensitivity may be a heritable/genetic risk factor for ASD. [Mh] MeSH terms primary: Acrodynia/genetics Child Development Disorders, Pervasive/epidemiology Family Health [Mh] MeSH terms secundary: Adult Aged Aged, 80 and over Australia/epidemiology Child Development Disorders, Pervasive/chemically induced Child Development Disorders, Pervasive/genetics Cohort Studies Female Genetic Predisposition to Disease Health Status Humans Infant Male Mercury/toxicity Middle Aged Poisons/toxicity Prevalence Questionnaires [Pt] Publication type: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Name of substance: 0 (Poisons); 7439-97-6 (Mercury) [Em] Entry month: 1109 [Cu] Class update date: 120329 [Lr] Last revision date: 120329 [Js] Journal subset: IM [Da] Date of entry for processing: 110729 [St] Status: MEDLINE [do] DOI: 10.1080/15287394.2011.590097

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[PMID]: 21078105 [Au] Autor: Lehman JS; Kuntz NL; Davis DM [Ad] Address: Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA. [Ti] Title: Localized aquadynia responsive to clonidine in a 13-year-old girl. [So] Source: Pediatr Dermatol;27(6):646-9, 2010 Nov-Dec. [Is] ISSN: 1525-1470 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: A 13-year-old girl sought medical care for pain in both palms that consistently occurred after brief exposure to water and resolved spontaneously 20 to 30 minutes after immersion. The pain was not associated with wrinkling of the palms. After excluding other causes of acrodynia and water-induced discomfort, we diagnosed the patient as having idiopathic localized aquadynia. Treatment with systemic clonidine led to a substantial improvement in her symptoms. To our knowledge, this patient represents the only fifth reported case of aquadynia and the first child affected by this enigmatic condition. [Mh] MeSH terms primary: Clonidine/therapeutic use Immersion/adverse effects Neuralgia/drug therapy Neuralgia/etiology Water/adverse effects [Mh] MeSH terms secundary: Adolescent Biopsy Female Humans Neuralgia/pathology Sympatholytics/therapeutic use [Pt] Publication type: CASE REPORTS; JOURNAL ARTICLE [Nm] Name of substance: 0 (Sympatholytics); 4205-90-7 (Clonidine); 7732-18-5 (Water) [Em] Entry month: 1107 [Js] Journal subset: IM [Da] Date of entry for processing: 101208 [St] Status: MEDLINE [do] DOI: 10.1111/j.1525-1470.2010.01132.x

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[PMID]: 20816345 [Au] Autor: Etzel RA [Ti] Title: Mercury exposure and children's health. Foreword. [So] Source: Curr Probl Pediatr Adolesc Health Care;40(8):185, 2010 Sep. [Is] ISSN: 1538-3199 [Cp] Country of publication: United States [La] Language: eng [Mh] MeSH terms primary: Acrodynia/etiology Environmental Exposure/adverse effects Mercury Compounds/toxicity Mercury Poisoning/prevention & control [Mh] MeSH terms secundary: Child Environmental Exposure/prevention & control Humans [Pt] Publication type: INTRODUCTORY JOURNAL ARTICLE [Nm] Name of substance: 0 (Mercury Compounds) [Em] Entry month: 1012 [Js] Journal subset: IM [Da] Date of entry for processing: 100906 [St] Status: MEDLINE [do] DOI: 10.1016/j.cppeds.2010.07.003

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