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Search on : Adiposis and Dolorosa [Words]
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[PMID]: 27884011
[Au] Autor:Djuric-Stefanovic A; Ebrahimi K; Sisevic J; Saranovic D
[Ad] Address:Department of Radiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
[Ti] Title:Gastroduodenal Lipomatosis in Familial Multiple Lipomatosis.
[So] Source:Med Princ Pract;26(2):189-191, 2017.
[Is] ISSN:1423-0151
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To present a case of gastroduodenal lipomatosis associated with familial multiple lipomatosis (FML). CLINICAL PRESENTATION AND INTERVENTION: A 58-year-old male presented with FML that manifested as multiple, painless, subcutaneous lipomas on his body; his mother had subcutaneous lipoma without a diagnosis of gastroduodenal lipomatosis. His lipid profile was normal. Abdominal computed tomography showed multiple, submucosal, polypoid lesions (of uniform density) of fat in the stomach and duodenum, and a small, similar lesion in the ileum. CONCLUSION: This case shows that gastrointestinal lipomatosis can manifest as FML.
[Mh] MeSH terms primary: Familial Multiple Lipomatosis/complications
Gastrointestinal Diseases/etiology
[Mh] MeSH terms secundary: Familial Multiple Lipomatosis/diagnostic imaging
Familial Multiple Lipomatosis/physiopathology
Gastrointestinal Diseases/diagnostic imaging
Gastrointestinal Diseases/physiopathology
Humans
Lipomatosis/diagnostic imaging
Lipomatosis/etiology
Lipomatosis/physiopathology
Male
Middle Aged
Tomography, X-Ray Computed
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171102
[Lr] Last revision date:171102
[Js] Journal subset:IM
[Da] Date of entry for processing:161125
[St] Status:MEDLINE
[do] DOI:10.1159/000454714

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[PMID]: 27757353
[Au] Autor:Buck DW; Herbst KL
[Ad] Address:Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, Mo.; and Department of Medicine, University of Arizona, Banner University Medical Center, Tucson, Ariz.
[Ti] Title:Lipedema: A Relatively Common Disease with Extremely Common Misconceptions.
[So] Source:Plast Reconstr Surg Glob Open;4(9):e1043, 2016 Sep.
[Is] ISSN:2169-7574
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Lipedema, or adiposis dolorosa, is a common adipose tissue disorder that is believed to affect nearly 11% of adult women worldwide. It is characterized most commonly by disproportionate adipocyte hypertrophy of the lower extremities, significant tenderness to palpation, and a failure to respond to extreme weight loss modalities. Women with lipedema report a rapid growth of the lipedema subcutaneous adipose tissue in the setting of stress, surgery, and/or hormonal changes. Women with later stages of lipedema have a classic "column leg" appearance, with masses of nodular fat, easy bruising, and pain. Despite this relatively common disease, there are few physicians who are aware of it. As a result, patients are often misdiagnosed with lifestyle-induced obesity, and/or lymphedema, and subjected to unnecessary medical interventions and fat-shaming. Diagnosis is largely clinical and based on criteria initially established in 1951. Treatment of lipedema is effective and includes lymphatic support, such as complete decongestive therapy, and specialized suction lipectomy to spare injury to lymphatic channels and remove the diseased lipedema fat. With an incidence that may affect nearly 1 in 9 adult women, it is important to generate appropriate awareness, conduct additional research, and identify better diagnostic and treatment modalities for lipedema so these women can obtain the care that they need and deserve.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 170816
[Lr] Last revision date:170816
[St] Status:PubMed-not-MEDLINE

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[PMID]: 26919646
[Au] Autor:Yu R; Wachsman A
[Ti] Title:VISUAL VIGNETTE.
[So] Source:Endocr Pract;22(8):1027, 2016 08.
[Is] ISSN:1530-891X
[Cp] Country of publication:United States
[La] Language:eng
[Mh] MeSH terms primary: Adiposis Dolorosa/pathology
Temporal Muscle/pathology
[Mh] MeSH terms secundary: Adiposis Dolorosa/complications
Facial Nerve Diseases/etiology
Facial Nerve Diseases/pathology
Humans
Male
Middle Aged
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1705
[Cu] Class update date: 170523
[Lr] Last revision date:170523
[Js] Journal subset:IM
[Da] Date of entry for processing:160227
[St] Status:MEDLINE
[do] DOI:10.4158/EP161236.VV

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[PMID]: 26289595
[Au] Autor:Wollina U; Heinig B; Langner D; Nowak A
[Ad] Address:Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany. uwollina@gmail.com.
[Ti] Title:Juxta-articular adiposis dolorosa (Dercum's disease type IV): report of four cases and treatment by dermolipectomy.
[So] Source:Wien Med Wochenschr;165(17-18):374-7, 2015 Sep.
[Is] ISSN:1563-258X
[Cp] Country of publication:Austria
[La] Language:eng
[Ab] Abstract:Juxta-articular adiposis dolorosa is a rare subtype of Dercum's disease. It manifests mainly on the medial parts of the knees. Pain and impaired mobility are common symptoms. We report on four females (aged between 52 and 83 years) who suffered from juxta-articular adiposis dolorosa for more than 10 years. These patients were successfully treated by dermolipectomy resulting in dramatically improved pain and mobility. Adverse effects and complications were minor with a lymph fistula in a single patient which was treated by surgery.
[Mh] MeSH terms primary: Adiposis Dolorosa/diagnosis
Adiposis Dolorosa/surgery
Lipectomy/methods
[Mh] MeSH terms secundary: Aged
Aged, 80 and over
Cutaneous Fistula/etiology
Cutaneous Fistula/surgery
Female
Fistula/etiology
Fistula/surgery
Humans
Lymphatic Diseases/etiology
Lymphatic Diseases/surgery
Middle Aged
Mobility Limitation
Pain Measurement
Postoperative Complications/etiology
Postoperative Complications/surgery
Reoperation
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1609
[Cu] Class update date: 171018
[Lr] Last revision date:171018
[Js] Journal subset:IM
[Da] Date of entry for processing:150821
[St] Status:MEDLINE
[do] DOI:10.1007/s10354-015-0378-1

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[PMID]: 26091459
[Au] Autor:Martinenghi S; Caretto A; Losio C; Scavini M; Bosi E
[Ad] Address:From the Diabetes Research Institute (SM, MS, EB); Department of Radiology, San Raffaele Hospital and Scientific Institute (CL); and San Raffaele Vita Salute University, Milan, Italy (AC, EB).
[Ti] Title:Successful Treatment of Dercum's Disease by Transcutaneous Electrical Stimulation: A Case Report.
[So] Source:Medicine (Baltimore);94(24):e950, 2015 Jun.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Dercum's disease is a rare condition of painful subcutaneous growth of adipose tissue. Etiology is unknown and pain is difficult to control. We report the case of a 57-year-old man with generalized diffuse Dercum's disease, who improved after the treatment with transcutaneous frequency rhythmic electrical modulation system (FREMS). Treatment consisted in 4 cycles of 30 minutes FREMS sessions over a 6-month period. Measures of efficacy included pain assessment (visual analogue scale, VAS), adipose tissue thickness by magnetic resonance imaging, total body composition and regional fat mass by dual-energy X-ray absorptiometry, physical disability (Barthel index), and health status (Short Form-36 questionnaire). After FREMS treatment the patient's clinical conditions significantly improved, with reduction of pain on the VAS scale from 64 to 17 points, improvement of daily life abilities (the Barthel index increased from 12 to 18) and amelioration of health status (higher scores than baseline in all Short Form-36 domains). Furthermore, we documented a 12 mm reduction in subcutaneous adipose tissue thickness at the abdominal wall and a 7040 g decrease in total body fat mass. FREMS therapy proved to be effective and safe in the treatment of this rare and disabling condition.
[Mh] MeSH terms primary: Adiposis Dolorosa/therapy
Electric Stimulation Therapy/methods
[Mh] MeSH terms secundary: Adipose Tissue
Body Composition
Body Mass Index
Disability Evaluation
Health Status
Humans
Male
Middle Aged
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1509
[Cu] Class update date: 170220
[Lr] Last revision date:170220
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:150620
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000000950

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[PMID]: 25672948
[Au] Autor:Petscavage-Thomas JM; Walker EA; Bernard SA; Bennett J
[Ad] Address:Department of Radiology, H066, Milton S. Hershey Medical Center, 500 University Drive, P.O. Box 850, Hershey, PA, 17033, USA, jthomas5@hmc.psu.edu.
[Ti] Title:Imaging findings of adiposis dolorosa vs. massive localized lymphedema.
[So] Source:Skeletal Radiol;44(6):839-47, 2015 Jun.
[Is] ISSN:1432-2161
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:PURPOSE: Adiposis dolorosa (Dercum's disease) is a condition of benign, painful subcutaneous lipomatous lesions associated with weakness, endocrine and lipid abnormalities, and mental disturbances. There is little information documenting the cross-sectional imaging findings that differentiate it from lipomatous and neoplastic soft tissue masses, or massive localized lymphedema. The purpose of this study was to provide a radiological case series of adiposis dolorosa. METHODS: A 10-year retrospective review of the picture archiving and communications system was performed. Two musculoskeletal radiologists reviewed images to confirm and document imaging features, location, size, and patient demographics. Medical records were reviewed to characterize patients into three groups: one group met at least three of the four criteria of Dercum's syndrome, the second group met less than three criteria, and the third group had clinical diagnosis of cellulitis of the lower extremity. RESULTS: Seventeen cases (25 masses) of adiposis dolorosa were found, nine cases of which met at least three criteria of Dercum's syndrome. All cases in the first two groups demonstrated skin thickening and lymphedema of subcutaneous fat, which was fluid attenuation on CT and low or intermediate T1-weighted and high STIR/T2-weighted MR signal. Two cases with pathology showed mild fatty infiltration with fibrous septa, and the third case showed massive localized lymphedema. The third group of ten cellulitis patients demonstrated non-mass-like subcutaneous edema with similar CT attenuation and MR signal characteristics to the first two groups, but differed by the presence of post-contrast enhancement and non-mass-like appearance in 90%. CONCLUSION: Imaging findings of adiposis dolorosa and massive localized lymphedema overlap, as do the symptoms and pathological features. Due to the mass-like engorgement of the soft tissues and pain, patients will often undergo imaging to exclude neoplasm or infection. Knowledge of these conditions and the characteristic imaging findings is important to prevent unnecessary biopsy and misdiagnosis.
[Mh] MeSH terms primary: Adiposis Dolorosa/diagnosis
Lymphedema/diagnosis
Magnetic Resonance Imaging/methods
Tomography, X-Ray Computed/methods
[Mh] MeSH terms secundary: Adult
Aged
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Observer Variation
Retrospective Studies
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1601
[Cu] Class update date: 170924
[Lr] Last revision date:170924
[Js] Journal subset:IM
[Da] Date of entry for processing:150213
[St] Status:MEDLINE
[do] DOI:10.1007/s00256-015-2114-8

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[PMID]: 25526345
[Au] Autor:Schaffer PR; Hale CS; Meehan SA; Shupack JL; Ramachandran S
[Ad] Address:New York University School of Medicine.
[Ti] Title:Adiposis dolorosa.
[So] Source:Dermatol Online J;20(12), 2014 Dec 16.
[Is] ISSN:1087-2108
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We report a 46-year-old woman with a nine-year history of obesity; chronic diffuse pain in the adipose tissue of her medial upper arms, lower trunk, and thighs; multiple biopsy-proven lipomas and angiolipomas; and a lipomatous pseudomass of the breast. Her systemic symptoms included generalized weakness, fatigue, memory impairment, and arthralgias. Although some of the lesions were tender, most were only appreciated with palpation. Her clinical history and histopathologic data suggested adiposis dolorosa (Dercum's disease). Owing to the chronic pain, an interdisciplinary approach with the use of analgesics and doxycycline has been initiated.
[Mh] MeSH terms primary: Adiposis Dolorosa/pathology
[Mh] MeSH terms secundary: Female
Humans
Middle Aged
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1508
[Cu] Class update date: 141220
[Lr] Last revision date:141220
[Js] Journal subset:IM
[Da] Date of entry for processing:141220
[St] Status:MEDLINE

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[PMID]: 25356401
[Au] Autor:Patel DA; Swan KG
[Ad] Address:Rutgers New Jersey Medical School Newark, New Jersey.
[Ti] Title:Francis Xavier Dercum: a man for all seasons.
[So] Source:Ann Clin Transl Neurol;1(3):233-7, 2014 Mar.
[Is] ISSN:2328-9503
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Francis Xavier Dercum (1856-1931) is known primarily for his prominence in the field of neurology and for his identification of "Adiposis Dolorosa", known as Dercum's disease. His brilliance, however, extends well beyond neurology. Born and raised in Philadelphia to parents of American and European descent, Dercum's natural curiosity oriented his interests toward medicine and philosophy. His scholarship flourished, and much recognition came his way. He died in Benjamin Franklin's Chair, closing what would be his last session as President of the American Philosophical Society. From anatomy, histology, pathology, and neurology to teaching, writing, and philosophy, Dercum's life was that of a man for all seasons.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1410
[Cu] Class update date: 170220
[Lr] Last revision date:170220
[Da] Date of entry for processing:141031
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1002/acn3.36

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[PMID]: 25044620
[Au] Autor:Rasmussen JC; Herbst KL; Aldrich MB; Darne CD; Tan IC; Zhu B; Guilliod R; Fife CE; Maus EA; Sevick-Muraca EM
[Ad] Address:The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
[Ti] Title:An abnormal lymphatic phenotype is associated with subcutaneous adipose tissue deposits in Dercum's disease.
[So] Source:Obesity (Silver Spring);22(10):2186-92, 2014 Oct.
[Is] ISSN:1930-739X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Investigational, near-infrared fluorescence (NIRF) lymphatic imaging was used to assess lymphatic architecture and contractile function in participants diagnosed with Dercum's disease, a rare, poorly understood disorder characterized by painful lipomas in subcutaneous adipose tissues. METHODS: After informed consent and as part of an FDA-approved feasibility study to evaluate lymphatics in diseases in which their contribution has been implicated, three women diagnosed with Dercum's disease and four control subjects were imaged. Each participant received multiple intradermal and subcutaneous injections of indocyanine green (ICG, total dose ≤400 µg) in arms, legs, and/or trunk. Immediately after injection, ICG was taken up by the lymphatics and NIRF imaging was conducted. RESULTS: The lymphatics in the participants with Dercum's disease were intact and dilated, yet sluggishly propelled lymph when compared to control lymphatics. Palpation of regions containing fluorescent lymphatic pathways revealed tender, fibrotic, tubular structures within the subcutaneous adipose tissue that were associated with painful nodules, and, in some cases, masses of fluorescent tissue indicating that some lipomas may represent tertiary lymphoid tissues. CONCLUSIONS: These data support the hypothesis that Dercum's disease may be a lymphovascular disorder and suggest a possible association between abnormal adipose tissue deposition and abnormal lymphatic structure and function.
[Mh] MeSH terms primary: Adiposis Dolorosa/complications
Adiposis Dolorosa/pathology
Lymphatic Diseases/etiology
Lymphatic Diseases/pathology
Subcutaneous Fat/pathology
[Mh] MeSH terms secundary: Female
Humans
Indocyanine Green
Infrared Rays
Lymphatic System/pathology
Middle Aged
Optical Imaging
Pain
Phenotype
[Pt] Publication type:CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Name of substance:IX6J1063HV (Indocyanine Green)
[Em] Entry month:1510
[Cu] Class update date: 170220
[Lr] Last revision date:170220
[Js] Journal subset:IM
[Da] Date of entry for processing:140722
[St] Status:MEDLINE
[do] DOI:10.1002/oby.20836

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[PMID]: 23809264
[Au] Autor:Tins BJ; Matthews C; Haddaway M; Cassar-Pullicino VN; Lalam R; Singh J; Tyrrell PN
[Ad] Address:Department of Radiology, Robert Jones and Agnes Hunt Orthopaedic Hospital, NHS Trust, Oswestry, UK. Bernhard.Tins@rjah.nhs.uk
[Ti] Title:Adiposis dolorosa (Dercum's disease): MRI and ultrasound appearances.
[So] Source:Clin Radiol;68(10):1047-53, 2013 Oct.
[Is] ISSN:1365-229X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:AIM: To describe ultrasound and magnetic resonance imaging (MRI) features of adiposis dolorosa, Dercum's disease, and to evaluate the MRI features prospectively against a large number of MRI examinations. MATERIALS AND METHODS: Institutional review board approval for this study was obtained. The imaging features at MRI and ultrasound of 13 cases of adiposis dolorosa (nine female, four male; age range 32-72 years) were reviewed. MRI findings typical for adiposis dolorosa were proposed and prospectively evaluated on 6247 MRI examinations performed over a period of 8 months. RESULTS: Adiposis dolorosa demonstrates multiple, oblong, fatty lesions in the superficial subcutaneous fatty tissue. They are mostly <2 cm in long axis diameter. They demonstrate nodular ("blush-like") increased fluid signal at unenhanced MRI and are markedly hyperechoic at ultrasound. There is no contrast medium enhancement at MRI and no increased Doppler signal at ultrasound. Most lesions were clinically asymptomatic, some were painful/tender. There was no imaging evidence of oedema or inflammation. During prospective validation of these MRI features on 6247 MRI examinations, two cases with typical imaging features were encountered; both were diagnosed as adiposis dolorosa on clinical review. All cases of adiposis dolorosa showed these imaging findings. This results in a very low likelihood that a nodular, blush-like appearance of subcutaneous fat on MRI is not due to adiposis dolorosa. DISCUSSION: Adiposis dolorosa, Dercum's disease, should be suggested in the presence of multiple (many) small, oblong, fatty lesions in the subcutaneous fatty tissue in adult patients if they are hyperechoic on ultrasound imaging or blush-like at unenhanced MRI; typically a small number of these lesions are tender/painful. Imaging does not demonstrate inflammation or oedema in relation to these lesions. These MRI features should suggest the diagnosis and are likely to be pathognomonic. The radiologist is often the first to suggest the diagnosis based on the imaging features.
[Mh] MeSH terms primary: Adiposis Dolorosa/diagnostic imaging
Adiposis Dolorosa/diagnosis
Magnetic Resonance Imaging/methods
[Mh] MeSH terms secundary: Adult
Aged
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Ultrasonography
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1310
[Cu] Class update date: 161125
[Lr] Last revision date:161125
[Js] Journal subset:IM
[Da] Date of entry for processing:130702
[St] Status:MEDLINE


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