Database : MEDLINE
Search on : Adrenal and Gland and Diseases [Words]
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[PMID]: 29505516
[Au] Autor:Lin J; Yu Y; Chen Y; Zheng M; Zhou D
[Ad] Address:Department of Urology and Center Laboratory, BenQ Medical Center.
[Ti] Title:Heterotopic pancreatic cyst in the adrenal gland: A case report and review of literature.
[So] Source:Medicine (Baltimore);97(1):e9414, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: The incidence of heterotopic pancreas (HP) is relatively rare and mainly found in the upper gastrointestinal tract, and no case of HP cyst in the adrenal gland has been reported. Informed consent has been obtained from the patient for the publication of the case details. PATIENT CONCERNS: A 21-year-old woman who presented with chronic lower back pain for a week without urinary disturbance or gastrointestinal discomfortable. DIAGNOSES: Ultrasound (US) revealed a left renal cyst, and computed tomography (CT) showed a cyst in the area of the adrenal gland. INTERVENTIONS: Cystectomy was successfully performed laparoscopically. Histopathologic examination of the removed cyst wall showed heterotopic pancreatic cyst accompanied by cystic degeneration. OUTCOMES: No unusual drainage or abdominal signs were observed during the 6-month follow-up. LESSONS: Despite of its rarity, HP accompanied by cyst formation in the adrenal gland area can present with waist pain. Therefore, the possibility of such disease needs to be considered. For thorough evaluation, in addition to abdominal US, CT, and/or magnetic resonance imaging, histopathological examination should sometimes be performed to make a definite diagnosis. Total excision and regular follow-up is necessary for such cases due to the potential risk of complications or recurrent cyst formation.
[Mh] MeSH terms primary: Adrenal Gland Diseases/diagnostic imaging
Choristoma
Pancreas
Pancreatic Cyst/diagnostic imaging
[Mh] MeSH terms secundary: Female
Humans
Young Adult
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180306
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009414

  2 / 13372 MEDLINE  
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[PMID]: 29367455
[Au] Autor:Dumontet T; Sahut-Barnola I; Septier A; Montanier N; Plotton I; Roucher-Boulez F; Ducros V; Lefrançois-Martinez AM; Pointud JC; Zubair M; Morohashi KI; Breault DT; Val P; Martinez A
[Ad] Address:GReD, Université Clermont Auvergne, CNRS, INSERM, Clermont-Ferrand, France.
[Ti] Title:PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal.
[So] Source:JCI Insight;3(2), 2018 Jan 25.
[Is] ISSN:2379-3708
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The adrenal cortex undergoes remodeling during fetal and postnatal life. How zona reticularis emerges in the postnatal gland to support adrenarche, a process whereby higher primates increase prepubertal androgen secretion, is unknown. Using cell-fate mapping and gene deletion studies in mice, we show that activation of PKA has no effect on the fetal cortex, while it accelerates regeneration of the adult cortex, triggers zona fasciculata differentiation that is subsequently converted into a functional reticularis-like zone, and drives hypersecretion syndromes. Remarkably, PKA effects are influenced by sex. Indeed, testicular androgens increase WNT signaling that antagonizes PKA, leading to slower adrenocortical cell turnover and delayed phenotype whereas gonadectomy sensitizes males to hypercorticism and reticularis-like formation. Thus, reticularis results from ultimate centripetal conversion of adult cortex under the combined effects of PKA and cell turnover that dictate organ size. We show that PKA-induced progenitor recruitment is sexually dimorphic and may provide a paradigm for overrepresentation of women in adrenal diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher

  3 / 13372 MEDLINE  
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[PMID]: 29429350
[Au] Autor:Doleschall M; Török D; Mészáros K; Luczay A; Halász Z; Németh K; Szücs N; Kiss R; Toke J; Sólyom J; Fekete G; Patócs A; Igaz P; Tóth M
[Ad] Address:Molekuláris Medicina Kutatócsoport, Magyar Tudományos Akadémia-Semmelweis Egyetem Budapest.
[Ti] Title:Szteroid-21-hidroxiláz-deficientia, a congenitalis adrenalis hyperplasia leggyakoribb oka. [Steroid 21-hydroxylase deficiency, the most frequent cause of congenital adrenal hyperplasia].
[So] Source:Orv Hetil;159(7):269-277, 2018 Feb.
[Is] ISSN:0030-6002
[Cp] Country of publication:Hungary
[La] Language:hun
[Ab] Abstract:Congenital adrenal hyperplasia is a group of genetic diseases due to the disablement of 7 genes; one of them is steroid 21-hydroxylase deficiency. The genes of congenital adrenal hyperplasia encode enzymes taking part in the steroidogenesis of adrenal gland. Steroid 21-hydroxylase deficiency is an autosomal recessive disorder caused by mutations of the steroid 21-hydroxylase gene. The mutations of steroid 21-hydroxylase gene cause 95% of the congenital adrenal hyperplasia cases. Although the non-classic steroid 21-hydroxylase deficiency with mild symptoms is seldom diagnosed, the classic steroid 21-hydroxylase deficiency may lead to life-threatening salt-wasting and adrenal crises due to the insufficient aldosterone and cortisol serum levels. The classic type requires life-long steroid replacement which may result in cushingoid side effects, and typical comorbidities may be also developed. The patients' quality of life is decreased, and their mortality is much higher than that of the population without steroid 21-hydroxylase deficiency. The diagnosis, consequences and the patients' life-long clinical care require a multidisciplinary approach: the specialists in pediatrics, internal medicine, endocrinology, laboratory medicine, genetic diagnostics, surgery, obstetrics-gynecology and psychology need to work together. Orv Hetil. 2018; 159(7): 269-277.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process
[do] DOI:10.1556/650.2018.30986

  4 / 13372 MEDLINE  
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[PMID]: 29498310
[Au] Autor:Bucsek MJ; Giridharan T; MacDonald CR; Hylander BL; Repasky EA
[Ad] Address:a Department of Immunology , Roswell Park Cancer Institute , Buffalo , NY , USA.
[Ti] Title:An overview of the role of sympathetic regulation of immune responses in infectious disease and autoimmunity.
[So] Source:Int J Hyperthermia;34(2):135-143, 2018 Mar.
[Is] ISSN:1464-5157
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Stress in patients and pre-clinical research animals plays a critical role in disease progression Activation of the sympathetic nervous system (SNS) by stress results in secretion of the catecholamines epinephrine (Epi) and norepinephrine (NE) from the adrenal gland and sympathetic nerve endings. Adrenergic receptors for catecholamines are present on immune cells and their activity is affected by stress and the accompanying changes in levels of these neurotransmitters. In this short review, we discuss how this adrenergic stress impacts two categories of immune responses, infections and autoimmune diseases. Catecholamines signal primarily through the ß2-adrenergic receptors present on innate and adaptive immune cells which are critical in responding to infections caused by pathogens. In general, this adrenergic input, particularly chronic stimulation, suppresses lymphocytes and allows infections to progress. On the other hand, insufficient adrenergic control of immune responses allows progression of several autoimmune diseases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180302
[Lr] Last revision date:180302
[St] Status:In-Data-Review
[do] DOI:10.1080/02656736.2017.1411621

  5 / 13372 MEDLINE  
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[PMID]: 29278623
[Au] Autor:Raic M
[Ad] Address:School of Medicine, University of Zagreb, Zagreb, Croatia, matea.raic92@gmail.com.
[Ti] Title:Depression and Heart Diseases: Leading Health Problems.
[So] Source:Psychiatr Danub;29 Suppl 4(Suppl 4):770-777, 2017 Dec.
[Is] ISSN:0353-5053
[Cp] Country of publication:Croatia
[La] Language:eng
[Ab] Abstract:Depression is the most common psychiatric disorder in the world population and the most frequent mental disorder in a primary health care. Unrecognized and untreated depression is associated with a poor outcome of treated chronic diseases which co-exist with depression. Depression and cardiovascular diseases are bidirectional related conditions, risks are for each other, and they often co-exist. Depression is a common disorder in cardiovascular patients with a prevalence of 20% to 45%, which is much more frequent than in the general population. In cardiac patients with acute myocardial infarction, depression occurs three times more often than in the general population. Depression has a direct effect on the pathophysiological changes of various organ systems, changing the values of blood pressure, heart rate, vasomotor tone, vascular resistance, blood viscosity and plasma volume. The potential mechanism for developing heart disease in depressed patients includes hypothalamic-pituitary-adrenal gland dysfunction, increased proinflammatory and prothrombotic factor activity, reduced omega-3 fatty acids, reduced heart rate variability, smoking, physical inactivity, reduced mood, self-esteem and self-efficacy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Process

  6 / 13372 MEDLINE  
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[PMID]: 29237697
[Au] Autor:Roucher-Boulez F; Brac de la Perriere A; Jacquez A; Chau D; Guignat L; Vial C; Morel Y; Nicolino M; Raverot G; Pugeat M
[Ad] Address:Laboratoire de Biochimie et Biologie Moléculaire Grand EstUM Pathologies Endocriniennes Rénales Musculaires et Mucoviscidose, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France florence.roucher@chu-lyon.fr.
[Ti] Title:Triple-A syndrome: a wide spectrum of adrenal dysfunction.
[So] Source:Eur J Endocrinol;178(3):199-207, 2018 Mar.
[Is] ISSN:1479-683X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Triple-A or Allgrove syndrome is an autosomal recessive disorder due to mutations in the gene, which encodes a nucleoporin named ALADIN. It is characterized by a classical clinical triad: alacrima, achalasia and adrenal insufficiency, the canonic symptoms that are associated with progressive peripheral neuropathy. Only a few cohorts have been reported. The objective of the present study was to characterize the various spectra of adrenal function in Triple-A patients. METHODS: A retrospective clinical and biological monitoring of 14 patients (10 families) was done in a single multidisciplinary French center. All had gene sequenced and adrenal function evaluation. RESULTS: Nine different mutations were found, including one new mutation: c.755G>C, p.(Trp252Ser). Regarding adrenal function, defects of the zona fasciculata and reticularis were demonstrated by increased basal ACTH levels and low DHEAS levels in all cases regardless of the degree of glucocorticoid deficiency. In contrast, mineralocorticoid function was always conserved: i.e., normal plasma renin level associated with normal aldosterone level. The main prognostic feature was exacerbation of neuropathy and cognitive disorders. CONCLUSIONS: These data suggest that, in Triple-A patients, adrenal function can be deficient, insufficient or compensated. In our cohort after the first decade of life, there does not appear to be any degradation of adrenal function over time. However, patients with compensated adrenal function should be informed and educated to manage a glucocorticoid replacement therapy in case of stressful conditions, with no need for systematic long-term treatment.
[Mh] MeSH terms primary: Adrenal Insufficiency/genetics
Esophageal Achalasia/genetics
Nerve Tissue Proteins/genetics
Nuclear Pore Complex Proteins/genetics
[Mh] MeSH terms secundary: Adolescent
Adrenal Insufficiency/complications
Adrenal Insufficiency/metabolism
Adrenal Insufficiency/physiopathology
Adrenocorticotropic Hormone/metabolism
Adult
Aged
Aldosterone/metabolism
Child
Cognition Disorders/etiology
Cognition Disorders/physiopathology
Cognition Disorders/psychology
Cohort Studies
Dehydroepiandrosterone Sulfate/metabolism
Disease Progression
Esophageal Achalasia/complications
Esophageal Achalasia/metabolism
Esophageal Achalasia/physiopathology
Female
France
Glucocorticoids/deficiency
Humans
Male
Middle Aged
Peripheral Nervous System Diseases/etiology
Peripheral Nervous System Diseases/physiopathology
Phenotype
Prognosis
Renin/metabolism
Retrospective Studies
Young Adult
Zona Fasciculata/metabolism
Zona Reticularis/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (AAAS protein, human); 0 (Glucocorticoids); 0 (Nerve Tissue Proteins); 0 (Nuclear Pore Complex Proteins); 4964P6T9RB (Aldosterone); 57B09Q7FJR (Dehydroepiandrosterone Sulfate); 9002-60-2 (Adrenocorticotropic Hormone); EC 3.4.23.15 (Renin)
[Em] Entry month:1802
[Cu] Class update date: 180220
[Lr] Last revision date:180220
[Js] Journal subset:IM
[Da] Date of entry for processing:171215
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0642

  7 / 13372 MEDLINE  
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[PMID]: 29384929
[Au] Autor:Park SY; Kwak MK; Kim HJ; Park HK; Suh KI; Yoo MH; Jin SY; Yun S; Byun DW
[Ad] Address:Division of Endocrinology and Metabolism, Departments of Internal Medicine.
[Ti] Title:Case report of a bilateral adrenal myelolipoma associated with Cushing disease.
[So] Source:Medicine (Baltimore);96(52):e9455, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Adrenal myelolipomas are rare benign tumors, composed of a variable mixture of mature adipose tissue and hematopoietic tissue. These tumors are frequently detected incidentally and are usually asymptomatic, and hormonally inactive. PATIENT CONCERNS: During a routine health checkup, a 52-year-old man was found to have a tumor on the bilateral adrenal glands. Abdominal computed tomography revealed a well-defined, heterogeneously enhanced bilateral adrenal mass, suggesting a myelolipoma. DIAGNOSES: The hormonal evaluation revealed adrenocorticotropic hormone (ACTH) dependent Cushing syndrome. INTERVENTIONS: The patient underwent left adrenalectomy, and transsphenoidal resection of a pituitary mass. The final diagnosis was adrenal myelolipoma associated with Cushing disease. OUTCOMES: Growth of right adrenal myelolipoma was detected during the 7-year follow-up. There were enhancing pituitary lesions in repeat magnetic resonance imaging of the sellar region, which implies persistent or recurrent pituitary adenoma. This case reinforces relationship between Cushing disease and adrenal myelolipoma. LESSONS: To the best of our knowledge, this is the first reported pathologically confirmed bilateral adrenal myelolipoma associated with Cushing disease. This report supports the idea that ACTH is associated with the development of adrenal myelolipoma.
[Mh] MeSH terms primary: Adrenal Gland Neoplasms/complications
Adrenal Gland Neoplasms/diagnosis
Myelolipoma/complications
Myelolipoma/diagnosis
Pituitary ACTH Hypersecretion/complications
Pituitary ACTH Hypersecretion/diagnosis
[Mh] MeSH terms secundary: Adrenal Gland Neoplasms/surgery
Adrenalectomy
Humans
Male
Middle Aged
Myelolipoma/surgery
Pituitary ACTH Hypersecretion/surgery
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180209
[Lr] Last revision date:180209
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009455

  8 / 13372 MEDLINE  
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[PMID]: 29212953
[Au] Autor:Scortegagna M; Berthon A; Settas N; Giannakou A; Garcia G; Li JL; James B; Liddington RC; Vilches-Moure JG; Stratakis CA; Ronai ZA
[Ad] Address:Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
[Ti] Title:The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion.
[So] Source:JCI Insight;2(23), 2017 Dec 07.
[Is] ISSN:2379-3708
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Primary and secondary hypertension are major risk factors for cardiovascular disease, the leading cause of death worldwide. Elevated secretion of aldosterone resulting from primary aldosteronism (PA) is a key driver of secondary hypertension. Here, we report an unexpected role for the ubiquitin ligase Siah1 in adrenal gland development and PA. Siah1a-/- mice exhibit altered adrenal gland morphology, as reflected by a diminished X-zone, enlarged medulla, and dysregulated zonation of the glomerulosa as well as increased aldosterone levels and aldosterone target gene expression and reduced plasma potassium levels. Genes involved in catecholamine biosynthesis and cAMP signaling are upregulated in the adrenal glands of Siah1a-/- mice, while genes related to retinoic acid signaling and cholesterol biosynthesis are downregulated. Loss of Siah1 leads to increased expression of the Siah1 substrate PIAS1, an E3 SUMO protein ligase implicated in the suppression of LXR, a key regulator of cholesterol levels in the adrenal gland. In addition, SIAH1 sequence variants were identified in patients with PA; such variants impaired SIAH1 ubiquitin ligase activity, resulting in elevated PIAS1 expression. These data identify a role for the Siah1-PIAS1 axis in adrenal gland organization and function and point to possible therapeutic targets for hyperaldosteronism.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180210
[Lr] Last revision date:180210
[St] Status:Publisher

  9 / 13372 MEDLINE  
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[PMID]: 29380334
[Au] Autor:Krishnamurthy D; Rahmoune H; Guest PC
[Ad] Address:Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
[Ti] Title:Mass Spectrometry Profiling of Pituitary Glands.
[So] Source:Methods Mol Biol;1735:439-447, 2018.
[Is] ISSN:1940-6029
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Many chronic diseases are associated with hypothalamic-pituitary-adrenal axis dysfunction. Therefore, proteomic profiling of the pituitary gland has potential to uncover new information on the underlying pathways affected in these conditions. This could lead to identification of new biomarkers or drug targets for development of novel therapeutics. Here we present a protocol for preparation of pituitary protein extracts and analysis of the major hormones and accessory proteins using liquid chromatography tandem mass spectrometry (LC-MS/MS). The same methods can be applied in the study of other tissues of the diffuse neuroendocrine system.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180130
[Lr] Last revision date:180130
[St] Status:In-Data-Review
[do] DOI:10.1007/978-1-4939-7614-0_31

  10 / 13372 MEDLINE  
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[PMID]: 29213000
[Au] Autor:Aota Y; Nonaka T; Kimura S; Honda T; Okuda Y; Watanabe T; Fujiwara K; Yokoyama T; Wakabayashi Y; Sakurai M; Gotoh A
[Ad] Address:Department of Internal Medicine, Kohsei Chuo General Hospital.
[Ti] Title:[A methotrexate-associated lympholiferative disorder patient with gastrointestinal perforation].
[So] Source:Nihon Ronen Igakkai Zasshi;54(4):567-572, 2017.
[Is] ISSN:0300-9173
[Cp] Country of publication:Japan
[La] Language:jpn
[Ab] Abstract:A 70-year-old woman was diagnosed with chronic rheumatoid arthritis and treated with methotrexate and prednisolone. She visited our hospital to determine the cause of her continuous fatigue and fever for the past three weeks. She consumed no food orally and was provided antibiotics because free air was found on computed tomography (CT). Intraperitoneal small lymphadenopathy and swelling of both adrenal glands was also found on CT, and MTX-associated lymphoproliferative disorder (MTX-LPD) was suspected. Am adrenal gland biopsy showed diffuse large B-cell lymphoma (DLBCL) associated with MTX-LPD. The causes of gastrointestinal perforation with collagen diseases have been reported to be functional gastrointestinal disorders with collagen diseases like amyloidosis, gastrointestinal infections in immunocompromised patients, and side effects of medication, such as steroids or NSAIDs and MTX. MTX-LPD is an uncommon side effect of methotrexate. To ensure its appropriate diagnosis and treatment, it is important to improve the degree of recognition of MTX-LPD, and a prompt response is needed.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171207
[Lr] Last revision date:171207
[St] Status:In-Process
[do] DOI:10.3143/geriatrics.54.567


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