Database : MEDLINE Search on : Alangiaceae [Words] References found : 30 [refine] Displaying: 1 .. 10   in format [Detailed]

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[PMID]: 29199255 [Au] Autor: Tanahashi T [Ad] Address: Kobe Pharmaceutical University. [Ti] Title: [Diversity of Secondary Metabolites from Some Medicinal Plants and Cultivated Lichen Mycobionts]. [So] Source: Yakugaku Zasshi;137(12):1443-1482, 2017. [Is] ISSN: 1347-5231 [Cp] Country of publication: Japan [La] Language: jpn [Ab] Abstract: Studies on the structural determination, biosynthesis, and biological activities of secondary metabolites from natural sources are significant in the field of natural products chemistry. This review focuses on diverse secondary metabolites isolated from medicinal plants and cultivated mycobionts of lichens in our laboratory. Monoterpene-tetrahydroisoquinoline glycosides and alkaloids isolated from Cephaelis acuminata and Alangium lamarckii gave important information on the biosynthesis of ipecac alkaloids. A variety of glycosides linked with a secologanin unit and indole alkaloids were obtained from medicinal plants belonging to the families of Rubiaceae, Apocynaceae, and Loganiaceae. Plant species of the four genera Fraxinus, Syringa, Jasminum, and Ligustrum of the family Oleaceae were chemically investigated to provide several types of secoiridoid and iridoid glucosides. The biosynthetic pathway leading from protopine to benzophenanthridine alkaloids in suspension cell cultures of Eschscholtzia californica was elucidated. The structures and biological activities of the bisbenzylisoquinoline alkaloids of Stephania cepharantha and Nelumbo nucifera were also investigated. In addition, the mycobionts of lichens were cultivated to afford various types of metabolites that differ from the lichen substances of intact lichens but are structurally similar to fungal metabolites. The biosynthetic origins of some metabolites were also studied. These findings suggest that cultures of lichen mycobionts could be sources of new bioactive compounds and good systems for investigating secondary metabolism in lichens. [Mh] MeSH terms primary: Alkaloids/isolation & purification Glycosides/isolation & purification Lichens/metabolism Plants, Medicinal/metabolism [Mh] MeSH terms secundary: Alangiaceae/metabolism Alkaloids/biosynthesis Alkaloids/chemistry Benzylisoquinolines Cephaelis/metabolism Eschscholzia/metabolism Glycosides/biosynthesis Glycosides/chemistry Iridoids Monoterpenes Oleaceae/metabolism Rubiaceae/metabolism Stephania/metabolism Tetrahydroisoquinolines [Pt] Publication type: JOURNAL ARTICLE; REVIEW [Nm] Name of substance: 0 (Alkaloids); 0 (Benzylisoquinolines); 0 (Glycosides); 0 (Iridoids); 0 (Monoterpenes); 0 (Tetrahydroisoquinolines); 56W89FBX3E (1,2,3,4-tetrahydroisoquinoline) [Em] Entry month: 1801 [Cu] Class update date: 180112 [Lr] Last revision date: 180112 [Js] Journal subset: IM [Da] Date of entry for processing: 171205 [St] Status: MEDLINE [do] DOI: 10.1248/yakushi.17-00147

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[PMID]: 28733150 [Au] Autor: Ren J; Xie YG; Huang YY; Zhu SL; Yan SK; Jin HZ; Zhang WD [Ad] Address: School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China. [Ti] Title: Seven new lignan glycosides from the branches of Alangium kurzii Craib var. laxifolium. [So] Source: Fitoterapia;121:152-158, 2017 Sep. [Is] ISSN: 1873-6971 [Cp] Country of publication: Netherlands [La] Language: eng [Ab] Abstract: Seven new lignan glycosides (1-3, 8-10, and 14) and 17 known compounds were isolated from the branches of Alangium kurzii Craib var. laxifolium. Their structures were established by spectroscopic analysis and circular dichroism (CD) and X-ray analysis. The isolated compounds were evaluated for their antibacterial activities against Staphylococcus aureus CI1011, Streptococcus suis CI1608, Salmonella gallinarum CI0912, Enterococcus faecalis CI1304, Aeromonas hydrophila CI1008, Escherichia coli CI151012, Vibrio parahaemolyticus CI150506, Klebsiella pneumoniae CI131216, Pseudomonas aeruginosa CI1011, Staphylococcus epidermidis CI1110, and Streptococcus agalactiae CI1302. Their minimum inhibitory concentrations (MICs) were determined by serial dilution in 96-well culture plates. [Mh] MeSH terms primary: Alangiaceae/chemistry Anti-Bacterial Agents/chemistry Glycosides/chemistry Lignans/chemistry [Mh] MeSH terms secundary: Anti-Bacterial Agents/isolation & purification Glycosides/isolation & purification Lignans/isolation & purification Microbial Sensitivity Tests Molecular Structure Plant Extracts/chemistry [Pt] Publication type: JOURNAL ARTICLE [Nm] Name of substance: 0 (Anti-Bacterial Agents); 0 (Glycosides); 0 (Lignans); 0 (Plant Extracts) [Em] Entry month: 1710 [Cu] Class update date: 171010 [Lr] Last revision date: 171010 [Js] Journal subset: IM [Da] Date of entry for processing: 170723 [St] Status: MEDLINE

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[PMID]: 26778440 [Au] Autor: Selin-Rani S; Senthil-Nathan S; Revathi K; Chandrasekaran R; Thanigaivel A; Vasantha-Srinivasan P; Ponsankar A; Edwin ES; Pradeepa V [Ad] Address: Division of Biopesticides and Environmental Toxicology, Sri Paramakalyani Centre for Excellence in Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi-627 412, Tirunelveli, Tamil Nadu, India. [Ti] Title: Toxicity of Alangium salvifolium Wang chemical constituents against the tobacco cutworm Spodoptera litura Fab. [So] Source: Pestic Biochem Physiol;126:92-101, 2016 Jan. [Is] ISSN: 1095-9939 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: Widespread use of synthetic pesticides has resulted in the development of insecticide-resistant populations of pests and harmful effects on human health and the environment. There is a need to identify alternative pest management strategies to reduce our reliance on conventional chemical pesticides. In recent years the use of botanical pesticides for protecting crops from insect pests has assumed greater importance. Methanol extract of Alangium salvifolium (L.f.) Wang has potential insecticidal activity against Spodoptera litura Fab. The active fractions were identified through chromatographic techniques as F-IV (Rf value=0.45) and F-VI (Rf value=0.63) and were subjected to GC-MS (GCMATE II). Fifty, 100 and 200ppm of active fractions were applied to fourth instar larvae and the mortality increased with higher concentrations. Relative consumption rate, relative growth rate, efficiency of conversion of ingested food and efficiency of conversion of digested food values all decreased in treated larvae, but approximate digestibility rate increased after treatment. The hydrolytic enzymes, such as acid phosphatase, alkaline phosphatase and the glycolytic enzyme lactate dehydrogenase were inhibited in treated larvae compared with controls. The histopathology study revealed that the epithelial columnar cells were enlarged, completely atrophied; intercellular spaces were swollen, and also noted a cytoplasmic ooze of cell material that mixed with food column. The present study clearly showed the active fractions from A. salvifolium as potential botanicals to control the larvae of S. litura. This is the first report for nutritional indices, enzymatic activities and histological effects of A. salvifolium chemical constituents against S. litura. Thus probably, this will be used as an alternative for synthetic pesticides against the polyphagous pest like S. litura. [Mh] MeSH terms primary: Alangiaceae Insecticides/toxicity Plant Extracts/toxicity Spodoptera/drug effects [Mh] MeSH terms secundary: Acid Phosphatase/metabolism Alkaline Phosphatase/metabolism Animals Eating/drug effects Gas Chromatography-Mass Spectrometry Insecticides/chemistry Intestines/drug effects Intestines/enzymology Intestines/pathology L-Lactate Dehydrogenase/metabolism Phytochemicals/analysis Phytochemicals/toxicity Plant Extracts/chemistry Plant Leaves Spodoptera/anatomy & histology Spodoptera/growth & development Spodoptera/metabolism [Pt] Publication type: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Name of substance: 0 (Insecticides); 0 (Phytochemicals); 0 (Plant Extracts); EC 1.1.1.27 (L-Lactate Dehydrogenase); EC 3.1.3.1 (Alkaline Phosphatase); EC 3.1.3.2 (Acid Phosphatase) [Em] Entry month: 1610 [Cu] Class update date: 161230 [Lr] Last revision date: 161230 [Js] Journal subset: IM [Da] Date of entry for processing: 160119 [St] Status: MEDLINE

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[PMID]: 26498463 [Au] Autor: Zhang Y; Liu YB; Li Y; Li L; Ma SG; Qu J; Jiang JD; Chen XG; Zhang D; Yu SS [Ad] Address: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China. [Ti] Title: Terpenoids from the roots of Alangium chinense. [So] Source: J Asian Nat Prod Res;17(11):1025-38, 2015. [Is] ISSN: 1477-2213 [Cp] Country of publication: England [La] Language: eng [Ab] Abstract: Two new norditerpenoids (1 and 2), four new sesquiterpenoids (3-6), and 22 known compounds (7-28) were isolated from an ethanolic extract of roots of Alangium chinense. The absolute configurations of 1-6 were assigned by experimental and calculated ECD spectra. The skeleton of the compounds (1 and 2) has been reported only one time so far. Compounds 1, 13, and 23 exhibited antiviral activity against coxsackie virus B3 with IC50 values of 38-67 µM. Compounds 8 and 9 displayed neuritis inhibitory activity against microglial inflammation factor, with IC50 values of 6.4 and 10.1 µM, respectively. None of the compounds were cytotoxic in the MTT assay. [Mh] MeSH terms primary: Alangiaceae/chemistry Antiviral Agents/isolation & purification Diterpenes/isolation & purification Enterovirus/drug effects Sesquiterpenes/isolation & purification [Mh] MeSH terms secundary: Antiviral Agents/chemistry Antiviral Agents/pharmacology Diterpenes/chemistry Humans Inhibitory Concentration 50 Molecular Structure Plant Roots/chemistry Sesquiterpenes/chemistry [Pt] Publication type: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Name of substance: 0 (Antiviral Agents); 0 (Diterpenes); 0 (Sesquiterpenes) [Em] Entry month: 1603 [Cu] Class update date: 151110 [Lr] Last revision date: 151110 [Js] Journal subset: IM [Da] Date of entry for processing: 151027 [St] Status: MEDLINE [do] DOI: 10.1080/10286020.2015.1082551

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[PMID]: 25645740 [Au] Autor: Pailee P; Prachyawarakorn V; Ruchirawat S; Mahidol C [Ad] Address: Laboratory of Natural Products, Chulabhorn Research Institute, Kamphang Phet 6 Road, Bangkok 10210 (Thailand). [Ti] Title: Bioactive cardinane sesquiterpenes from the stems of Alangium salviifolium. [So] Source: Chem Asian J;10(4):910-4, 2015 Apr. [Is] ISSN: 1861-471X [Cp] Country of publication: Germany [La] Language: eng [Ab] Abstract: A dichloromethane extract of the stems of Alangium salviifolium afforded twelve cardinane sesquiterpenes, seven of which are new alangenes A-G (1-7) and five known compounds (8-12). Their structures were elucidated on the basis of spectroscopic techniques including UV, IR, and NMR spectroscopies, and mass spectrometry. Most of the tested compounds exhibited very potent aromatase inhibition properties, especially in the case of the cardinane sesquiterpenes 1, 5-8, and 10 (IC50 values of 0.09, 0.13, 0.30, 0.06, 2.05, and 1.19 µM, respectively), which are significantly better than that of the positive control (ketoconazole, IC50 of 2.4 µM). Compounds 1 and 4 exhibited selective cytotoxicity against the MOLT-3 cancer cell line with IC50 values of 7.9 and 2.1 µg mL(-1) , respectively. [Mh] MeSH terms primary: Alangiaceae/chemistry Plant Stems/chemistry Sesquiterpenes/chemistry Sesquiterpenes/pharmacology [Mh] MeSH terms secundary: Antineoplastic Agents, Phytogenic/chemistry Antineoplastic Agents, Phytogenic/pharmacology Cell Line, Tumor Humans Molecular Structure [Pt] Publication type: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Name of substance: 0 (Antineoplastic Agents, Phytogenic); 0 (Sesquiterpenes) [Em] Entry month: 1510 [Cu] Class update date: 150326 [Lr] Last revision date: 150326 [Js] Journal subset: IM [Da] Date of entry for processing: 150204 [St] Status: MEDLINE [do] DOI: 10.1002/asia.201403253

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[PMID]: 25452263 [Au] Autor: Yagi N; Nakahashi H; Kashima Y; Miyazawa M [Ad] Address: Picaso Cosmetics Laboratory Limited. [Ti] Title: Isolation and biological activity of a novel cadinane-type sesquiterpenoid from the essential oil of Alangium salviifolium. [So] Source: J Oleo Sci;63(12):1223-9, 2014. [Is] ISSN: 1347-3352 [Cp] Country of publication: Japan [La] Language: eng [Ab] Abstract: The components of the essential oil from the roots of Alangium salviifolium were analyzed by capillary gas chromatography-mass spectrometry (GC-MS). Ninety compounds, representing 74.5% of the total oil, were identified; the main components of the oil were epi-α-cadinol, followed by trans-2-hydroxycalamenene, cadalene, and cadina-4,10(15)-dien-3-one. A further unknown component comprised 5.5% of the oil. Therefore, the essential oil was purified by flash column chromatography to isolate this component. Its structure was established using extensive spectroscopic data analyses, including NMR, HR-EI-MS, and IR. The results showed that this isolated compound was (-)-7, 8-dihydroxycalamenal, which is a novel cadinane-type sesquiterpenoid. This compound was tested for its antioxidant activity and inhibition of tyrosinase, and showed particularly strong inhibition effects. [Mh] MeSH terms primary: Alangiaceae/chemistry Antioxidants Enzyme Inhibitors Monophenol Monooxygenase/antagonists & inhibitors Oils, Volatile/chemistry Plant Oils/chemistry Plant Roots/chemistry Sesquiterpenes/isolation & purification Sesquiterpenes/pharmacology Tetrahydronaphthalenes/isolation & purification Tetrahydronaphthalenes/pharmacology [Mh] MeSH terms secundary: Chromatography/methods Gas Chromatography-Mass Spectrometry/methods Oils, Volatile/isolation & purification Plant Oils/isolation & purification Sesquiterpenes/analysis Sesquiterpenes/chemistry Tetrahydronaphthalenes/chemistry [Pt] Publication type: JOURNAL ARTICLE [Nm] Name of substance: 0 (7,8-dihydroxycalamenal); 0 (Antioxidants); 0 (Enzyme Inhibitors); 0 (Oils, Volatile); 0 (Plant Oils); 0 (Sesquiterpenes); 0 (Tetrahydronaphthalenes); 0 (cadinane); EC 1.14.18.1 (Monophenol Monooxygenase) [Em] Entry month: 1506 [Cu] Class update date: 141202 [Lr] Last revision date: 141202 [Js] Journal subset: IM [Da] Date of entry for processing: 141203 [St] Status: MEDLINE

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[PMID]: 24502168 [Au] Autor: Zahan R; Nahar L; Nesa ML [Ad] Address: Department of Pharmacy, University of Rajshahi, Rajshahi-6025, Bangladesh. [Ti] Title: Antinociceptive and anti-inflammatory activities of flower (Alangium salvifolium) extract. [So] Source: Pak J Biol Sci;16(19):1040-5, 2013 Oct 01. [Is] ISSN: 1028-8880 [Cp] Country of publication: Pakistan [La] Language: eng [Ab] Abstract: The present study aimed to evaluate the antinociceptive and anti-inflammatory activity of Alangium salvifolium (AS) flower in mice. The antinociceptive activity was determined using tail immerson, acetic acid induced writhing and formalin induced licking test. Antiinflammatory effects were evaluated using carrageenan and formalin induced paw edema in mice. The methanol extract (50 and 100 mg kg(-1)) of flower of AS followed by chloroform extract (100 mg kg(-1)) produced a significant inhibition of both phases of the formalin pain test in mice, a reduction in mice writhing induced by acetic acid and delayed the response of mice to hot water thermal stimulation in tail immersion test. All flowers extract of AS also produced a substantial inhibition (nearly 50%) of carrageenan and formalin induced paw edema. The inhibitions were similar to those produced by indomethacin, p.o. The different alkaloids and flavonoids found in the extract could be account for the antinociceptive and anti-inflammatory actions. [Mh] MeSH terms primary: Alangiaceae/chemistry Analgesics/chemistry Analgesics/pharmacology Anti-Inflammatory Agents/chemistry Anti-Inflammatory Agents/pharmacology Plant Extracts/pharmacology [Mh] MeSH terms secundary: Alkaloids/chemistry Alkaloids/pharmacology Animals Flavonoids/chemistry Flavonoids/pharmacology Flowers/chemistry Male Mice Plant Extracts/chemistry [Pt] Publication type: JOURNAL ARTICLE [Nm] Name of substance: 0 (Alkaloids); 0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Flavonoids); 0 (Plant Extracts) [Em] Entry month: 1404 [Cu] Class update date: 150311 [Lr] Last revision date: 150311 [Js] Journal subset: IM [Da] Date of entry for processing: 140208 [St] Status: MEDLINE

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[PMID]: 23734721 [Au] Autor: Zhang Y; Liu YB; Li Y; Ma SG; Li L; Qu J; Zhang D; Chen XG; Jiang JD; Yu SS [Ad] Address: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. [Ti] Title: Sesquiterpenes and alkaloids from the roots of Alangium chinense. [So] Source: J Nat Prod;76(6):1058-63, 2013 Jun 28. [Is] ISSN: 1520-6025 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: Four new sesquiterpenes (1-4), four new alkaloids (5a, 6a, 6b, and 7), and nine known compounds (5b and 8-15) were isolated from an ethanolic extract of roots of Alangium chinense. The structure of 1 was confirmed by X-ray crystallography. The configurations of 5 and 6 were assigned by chiral HPLC analysis and CD spectra. Compounds 3, 4, 8-13, and 15 exhibited antiviral activity against Coxsackie virus B3 with IC50 values of 1.4-15.4 µM. Compounds 2-4, 7, and 9-13 showed antioxidant activities against Fe(2+)-cysteine-induced rat liver microsomal lipid peroxidation, with IC50 values of 3.8-45.7 µM. Compound 5b displayed neuritis inhibitory activity against microglial inflammation factor, with an IC50 value of 6.7 µM. None of the compounds exhibited detectable cytotoxic activity toward any of five tumor cell lines (A549, Be-17402, BGC-823, HCT-8, and A2780) in the MTT assay. [Mh] MeSH terms primary: Alangiaceae/chemistry Alkaloids/isolation & purification Antiviral Agents/isolation & purification Drugs, Chinese Herbal/isolation & purification Sesquiterpenes/isolation & purification [Mh] MeSH terms secundary: Alkaloids/chemistry Alkaloids/pharmacology Animals Antiviral Agents/chemistry Antiviral Agents/pharmacology Cercopithecus aethiops Crystallography, X-Ray Drugs, Chinese Herbal/chemistry Drugs, Chinese Herbal/pharmacology Enterovirus/drug effects Humans Inhibitory Concentration 50 Molecular Conformation Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plant Roots/chemistry Rats Sesquiterpenes/chemistry Sesquiterpenes/pharmacology Vero Cells [Pt] Publication type: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Name of substance: 0 ((2S)-N-hydroxybenzylanabasine); 0 (Alkaloids); 0 (Antiviral Agents); 0 (Drugs, Chinese Herbal); 0 (Sesquiterpenes) [Em] Entry month: 1310 [Cu] Class update date: 130628 [Lr] Last revision date: 130628 [Js] Journal subset: IM [Da] Date of entry for processing: 130606 [St] Status: MEDLINE [do] DOI: 10.1021/np4000747

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[PMID]: 23074898 [Au] Autor: Chakraborty M; Mukhopadhyay S [Ad] Address: Department of Chemistry, Taki Government College, Taki, North 24 Parganas, West Bengal, India. mumu_chak@yahoo.com [Ti] Title: Angustinine--a new benzopyridoquinolizine alkaloid from Alangium lamarckii. [So] Source: Nat Prod Commun;7(9):1169-70, 2012 Sep. [Is] ISSN: 1934-578X [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: A new benzopyridoquinolizine alkaloid, designated as angustinine (1), was isolated from the root bark of Alangium lamarckii Thwaites, along with the known ipecac alkaloid, emetine. Investigation of the stem bark of the same plant resulted in the isolation of another known ipecac alkaloid, cephaeline. The structure of the new alkaloid (1) was elucidated on the basis of 2D NMR spectralanalysis. [Mh] MeSH terms primary: Alangiaceae/chemistry Alkaloids/isolation & purification [Mh] MeSH terms secundary: Alkaloids/chemistry Magnetic Resonance Spectroscopy [Pt] Publication type: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Name of substance: 0 (Alkaloids); 0 (angustinine) [Em] Entry month: 1211 [Cu] Class update date: 121018 [Lr] Last revision date: 121018 [Js] Journal subset: IM [Da] Date of entry for processing: 121019 [St] Status: MEDLINE

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[PMID]: 22008064 [Au] Autor: Ahad HA; Padmaja BS; Sravanthi M; Ramyasree P; Kavitha K [Ad] Address: Department of Pharmaceutics, College of Pharmacy, Sri Krishnadevaraya University, Anantapur- 515003, Andhra Pradesh, India. abdulhindustan@rediffmail.com [Ti] Title: Phytochemical screening and anti-inflammatory actions of Alangium salviifolium root extract. [So] Source: Nat Prod Res;26(17):1649-53, 2012. [Is] ISSN: 1478-6427 [Cp] Country of publication: England [La] Language: eng [Ab] Abstract: Alangium salviifolium root was screened for phytochemical and anti-inflammatory properties. The percentage inhibition of carrageenan induced paw oedema was studied in rats. Alangium salvifolium gave maximum extractive values with Ethanol and the Loss on Drying value, total ash value and acid-insoluble ash and water soluble ash values were within limits. The extract gave positive tests for phytosterols, triterpenes, flavonoids, carbohydrates and alkaloids. The extract was free from glycosides, saponins, tannins, proteins and amino acids. In acute toxicity studies, Alangium salviifolium root extract was found to be safe up to 3000 mg kgâ�»¹, p.o. in the albino rats. The Alangium salviifolium root gave significant per cent inhibition of the maximal paw oedema and very highly significant per cent inhibition of total paw oedema during 6 h. This study revealed that Alangium salviifolium root has good anti-inflammatory actions when compared with Diclofenac sodium. [Mh] MeSH terms primary: Alangiaceae/chemistry Anti-Inflammatory Agents/chemistry Anti-Inflammatory Agents/therapeutic use Plant Extracts/chemistry Plant Extracts/therapeutic use Plant Roots/chemistry [Mh] MeSH terms secundary: Animals Diclofenac/therapeutic use Edema/drug therapy Rats [Pt] Publication type: JOURNAL ARTICLE [Nm] Name of substance: 0 (Anti-Inflammatory Agents); 0 (Plant Extracts); 144O8QL0L1 (Diclofenac) [Em] Entry month: 1212 [Cu] Class update date: 131121 [Lr] Last revision date: 131121 [Js] Journal subset: IM [Da] Date of entry for processing: 111020 [St] Status: MEDLINE [do] DOI: 10.1080/14786419.2011.589054

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