Database : MEDLINE
Search on : Angioedema [Words]
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[PMID]: 29410040
[Au] Autor:Zuraw BL
[Ad] Address:Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego and San Diego VA Healthcare, La Jolla, Calif. Electronic address: bzuraw@ucsd.edu.
[Ti] Title:Hereditary angioedema with normal C1 inhibitor: Four types and counting.
[So] Source:J Allergy Clin Immunol;141(3):884-885, 2018 Mar.
[Is] ISSN:1097-6825
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:EDITORIAL
[Em] Entry month:1802
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:In-Data-Review

  2 / 7158 MEDLINE  
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[PMID]: 29514728
[Ti] Title:Health care burden and treatment patterns in commercially insured children with chronic idiopathic/spontaneous urticaria: A real-world study in the United States.
[So] Source:Allergy Asthma Proc;, 2018 Mar 07.
[Is] ISSN:1539-6304
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Chronic idiopathic urticaria (CIU)/spontaneous urticaria (CSU) is defined by the presence of wheals,angioedema, or both for 6 weeks, with or without an identifiable trigger. Real-world health care data among children withCIU/CSU remain scarce. OBJECTIVES: To describe treatment patterns, health care resource utilization (HRU), and costs in pediatric patients with CIU/CSU (12 years old) and to compare these with pediatric patients without CIU/CSU. METHODS: A commercial administrative claims data base (September 2013 to June 2016) was used. The CIU/CSU cohort included pediatric patients with either two or more claims for a diagnosis of urticaria 6 weeks apart or one or more claimsfor a diagnosis of urticaria and one or more claims for a diagnosis of angioedema 6 weeks apart (index was defined as the first claim). The control cohort comprised pediatric patients without urticaria or angioedema (index randomly assigned). Patients with 6 months of eligibility before and after the index date were excluded. HRU and costs were compared between the cohorts during the observation period after propensity score matching. RESULTS: A total of 6109 pediatric patients with CIU/CSU were selected, and 6107 were 1:1 matched with controls. Thepatients with CIU/CSU who had a mean +/- standard deviation age of 4.58 +/- 3.36 years, and 47.9% were girls. CIU/CSU relatedmedication use increased after diagnosis (e.g., baseline versus 6-month follow-up, 2.2 versus 8.0% for nonsedatingprescription H1 antihistamines; 7.4 versus 17.4% for oral corticosteroids). Relative to the controls, the patients with CIU/CSU had higher rates of HRU (incidence rate ratios of 1.71, 2.39, and 2.07 for inpatient, emergency department, and outpatient visits, respectively; all p < 0.01), and higher all-cause per patient per year costs (mean cost differences of $2090, $1606, and $483 for total, medical, and pharmacy costs, respectively; all p < 0.01). CONCLUSION: This study highlighted unmet needs in pediatric patients with CIU/CSU who had increased medication (e.g.,oral corticosteroids) and HRU burden after a diagnosis for CIU/CSU, and higher rates of HRU and costs relative to thosewithout CIU/CSU.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.2500/aap.2018.39.4129

  3 / 7158 MEDLINE  
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[PMID]: 29513968
[Au] Autor:Korzeniowska K; Cielewiczi A; Pawlaczyk M; Motowidlo K; Andrys-Wawrzyniak I; Jablecka A
[Ti] Title:ANGIOEDEMA AFTER ANGIOTENSIN-CONVERTING ENZYME INHIBITORS.
[So] Source:Acta Pol Pharm;74(3):983-986, 2017 May.
[Is] ISSN:0001-6837
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:Angiotensin-converting enzyme inhibitors (ACEI) are one of the most frequently used drugs in the therapy of cardiovascular diseases. Beneficial therapeutic effects may be accompanied by different adverse reactions including angioedema. Recently published data suggest that ACEI-induced angioedema can be life-threatening without emergent intervention, for example due to the respiratory arrest. Monitoring this adverse Jreaction may be especially important for elderly patients who probably receive many different medicines and supplements and thus might be particularly at risk of adverse drug reactions. In the paper we describe two cases of ACEI-induced angioedema in older patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process

  4 / 7158 MEDLINE  
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[PMID]: 29513832
[Au] Autor:Pereira JCC; Szpilman D; Haddad Junior V
[Ad] Address:Faculdade de Medicina, Faculdades Pequeno Príncipe, Curitiba, PR, Brasil.
[Ti] Title:Anaphylactic reaction/angioedema associated with jellyfish sting.
[So] Source:Rev Soc Bras Med Trop;51(1):115-117, 2018 Jan-Feb.
[Is] ISSN:1678-9849
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:The most frequent jellyfish in Southern Brazil causes mainly local pain and skin plaques. A 3-year-old female bather presented an erythematous, irregular plaque on the left forearm after contact with a jellyfish and intense facial angioedema with facial flushing. The lungs had vesicular murmur, wheezes, and snorts, and pink and spumous secretion in the airways with intercostal retraction. She was administered subcutaneous adrenaline (0.1mg/kg) and hydrocortisone intravenous (10mg/kg) with total recovery in a few minutes. The manifestations of anaphylactic reactions are distinct from those of envenomations, and prompt and adequate care is fundamental in these situations.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process

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[PMID]: 29513108
[Au] Autor:Grivceva-Panovska V; Kosnik M; Korosec P; Andrejevic S; Karadza-Lapic L; Rijavec M
[Ad] Address:a Dermatology Clinic, School of Medicine, Ss. Cyril and Methodius University , Skopje , Republic of Macedonia.
[Ti] Title:Hereditary angioedema due to C1-inhibitor deficiency in Macedonia: clinical characteristics, novel SERPING1 mutations, and genetic factors modifying the clinical phenotype.
[So] Source:Ann Med;:1-23, 2018 Mar 07.
[Is] ISSN:1365-2060
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare disease, characterized by swellings. We aimed to characterize on a clinical and molecular basis C1-INH-HAE patients in the Republic of Macedonia. RESULTS: All 15 patients from six unrelated families were diagnosed with C1-INH-HAE type I, with a mean age of symptom onset of 11 years and an average delay of diagnosis of 7 years. Patients reported on average 31 angioedema attacks/year, with a median clinical severity score (CSS) of 7. We identified three known mutations, and two mutations (c.813_818delCAACAA and c.1488T > G) were reported for the first time. To address the genotype-phenotype association, a pooled analysis including 78 C1-INH-HAE south-eastern European patients was performed, with additional analysis of F12-46C/T and KLKB1-428G/A polymorphisms. We demonstrated that patients with nonsense and frameshift mutations, large deletions/insertions, splicing defects, and mutations at Arg444 exhibited an increased CSS compared with missense mutations, excluding mutations at Arg444. In addition, the CC F12-46C/T polymorphism was suggestive of earlier disease onset. DISCUSSION: Genetic analysis helped identify the molecular basis of C1-INH-HAE given that causative mutations in SERPING1 were detected in all patients, including an infant before the appearance of clinical symptoms. We identified two novel mutations and further corroborated the genotype-phenotype relationship, wherein mutations with a clear effect on C1-INH function predispose patients to a more severe disease phenotype and CC F12-46C/T predisposes patients to earlier disease onset.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1080/07853890.2018.1449959

  6 / 7158 MEDLINE  
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[PMID]: 29512945
[Au] Autor:Pawar M; Zawar V; Kumavat S; Daga S
[Ad] Address:MVP's Dr. VP Medical College & Hospital & Research Centre, Nashik, Maharashtra, India.
[Ti] Title:Chronic, persistent angioedema and sinusitis-like presentation of multibacillary leprosy.
[So] Source:J Dtsch Dermatol Ges;, 2018 Mar 07.
[Is] ISSN:1610-0387
[Cp] Country of publication:Germany
[La] Language:eng
[Pt] Publication type:LETTER
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:Publisher
[do] DOI:10.1111/ddg.13469

  7 / 7158 MEDLINE  
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[PMID]: 29512375
[Au] Autor:Yazici S; Nacaroglu HT; Bahçeci Erdem S; Karaman S; Can D
[Ad] Address:Department of Pediatrics, Medical Faculty, Balikesir University, Balikesir, Turkey.
[Ti] Title:Angioedema Due to Lamiaceae Allergy.
[So] Source:Iran J Allergy Asthma Immunol;17(1):97-99, 2018 Feb.
[Is] ISSN:1735-1502
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:We present a 13-year-old male childallergic to three different plants (Salvia officinalis, Mentha piperita and Origanum onites L.) of Lamiaceae family. The patient developed angioedema 20-30 minutes after eating chicken meat with cheddar cheese. There was no history of allergy. Oral food challenge (OFC) with both cheddar cheese and chicken meat was negative. Skin tests for inhalant allergens were negative. 3 weeks later, the patient was admitted with angioedema after drinking sage tea. OFC with sage was applied and angioedema was observed. It was recognized that the first trigger, chicken meat with cheddar cheese, included oregano (Origanum onites L.). OFC for oregano was positive. Prick to prick test for Lamiaceae herbs (oregano, sage, mint) was performed. A positive reaction was observed only to mint. OFC was repeated with fresh mint and angioedema developed after 16 hours. Diagnose of Lamiaceae allergy is complicated and cross-sensitivity is common. Skin prick test (prick to prick)revealed a positive response only to mint but not to oregano and sage. Commercial radioallergosorbent (RAST) tests are available only for a few members of the family. Finally, thediagnose is based mainly on OFC. Spices from Lamiaceae group should be considered as potential triggers of allergic reactions.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Data-Review

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[PMID]: 29510233
[Au] Autor:Brestoff JR; Tesfazghi MT; Zaydman MA; Jackups R; Kim BS; Scott MG; Gronowski AM; Grossman BJ
[Ad] Address:Division of Laboratory and Genomic Medicine, Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO. Electronic address: brestoff@wustl.edu.
[Ti] Title:The B antigen protects against the development of red meat allergy.
[So] Source:J Allergy Clin Immunol Pract;, 2018 Feb 21.
[Is] ISSN:2213-2201
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:Publisher

  9 / 7158 MEDLINE  
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[PMID]: 29508719
[Au] Autor:Nettis E; Cegolon L; Di Leo E; Canonica WG; Detoraki A; Italian OCUReL Study Group
[Ad] Address:Department of Emergency and Organ Transplantation, School of Allergology and Clinical Immunology, University of Bari Aldo Moro, Bari, Italy.
[Ti] Title:Omalizumab in elderly patients with chronic spontaneous urticaria: An Italian real-life experience.
[So] Source:Ann Allergy Asthma Immunol;120(3):318-323, 2018 Mar.
[Is] ISSN:1534-4436
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:BACKGROUND: Omalizumab therapy is effective and safe in patients with chronic spontaneous urticaria (CSU) resistant to nonsedating histamine (H ) antihistamines (nsAHs). OBJECTIVE: To evaluate the efficacy and safety of omalizumab in elderly (aged ≥65 years) patients with nonsedating H -antihistamine-refractory CSU in a real-life setting. METHODS: Patients with nonsedating H -antihistamine-refractory CSU (n = 322) treated with omalizumab administered every 4 weeks in doses of 300 mg for 24 weeks were divided into 2 groups according to age at omalizumab treatment onset: 15 to 64 years and 65 years or older. Treatment response was assessed using a 7-day urticaria activity score (UAS7). Adverse effects of omalizumab therapy were recorded. RESULTS: Among patients, 32 (9.9%) were 65 years or older. At baseline, CSU characteristics were generally similar among the groups, although the presence of angioedema was statistically significantly lower in patients younger than 65 years. Any differences in weekly itch severity score, hive score, and UAS7 between the 2 age groups were not significant at weeks 4, 12, and 24, with the exception of the hive score at 24 weeks and the UAS7 at week 24. No significant between-group differences were seen in the proportion of patients with a UAS7 of 6 or lower and with a UAS7 score of 0 at weeks 4, 12, 24, and 40. The proportion of patients with at least one adverse event reported as suspected to be caused by study drug was 10% in the younger group vs 6.3% in the older group (P = .53). CONCLUSION: Our study found that omalizumab is a well-tolerated and effective therapy for elderly patients with nonsedating H -antihistamine-refractory CSU.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:In-Data-Review

  10 / 7158 MEDLINE  
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[PMID]: 29189183
[Au] Autor:Buquicchio R; Ventura MT; Traetta PL; Nenna S; Iadarola G; Magrone T
[Ad] Address:Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari Medical School, Policlinico, Bari, Italy.
[Ti] Title:A Multicenter Study of IgE Sensitization to and Diet Recommendations.
[So] Source:Endocr Metab Immune Disord Drug Targets;18(2):170-174, 2018 Feb 13.
[Is] ISSN:2212-3873
[Cp] Country of publication:United Arab Emirates
[La] Language:eng
[Ab] Abstract:BACKGROUND: Allergy to Anisakis simplex (s.) is spreading due to the increased consumption of raw, smoked or marinated fish. In man, Anisakis s. can directly attack the gastrointestinal mucosa, provoking a parasitosis known as anisakiasis, or giving rise to the formation of IgE and, finally, inducing IgE-mediated reactions like urticaria, angioedema and anaphylactic shock. During recent years, a dietary approach to Anisakis s. infestation has also been addressed. METHODS: A total of 620 patients with urticaria, angioedema, or both and a history of anaphylaxis following consumption of raw, smoked or marinated fish were recruited, evaluated for specific IgE levels to Anisakis s. and subjected to Skin Prick test. Following 18 month fish-free diet, patients were reevaluated at 6, 12 and 18 months, respectively. Patients undergoing diet were selected among those who had a clinical history with multiple accesses to first aid. RESULTS: After 6-month fish-free diet, we recorded an improvement of symptoms and a remarkable reduction of specific IgE levels. The extension of the diet over 6 months in some cases resulted in a further reduction of specific IgE levels. CONCLUSION: Data obtained confirm the importance of a fish-free diet in patients with severe symptoms since a new antigenic exposure coincides with a relapse of symptoms and increased IgE levels. This last point should be kept in mind and carefully evaluated in patients at risk for anaphylaxis or angioedema.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:In-Process
[do] DOI:10.2174/1871530318666171129211350


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