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Search on : Angioid and Streaks [Words]
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[PMID]: 29480271
[Au] Autor:Govindhari V; Chhablani J
[Ad] Address:Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Hyderabad, Telangana, India.
[Ti] Title:To laser or not?
[So] Source:Indian J Ophthalmol;66(3):463-466, 2018 Mar.
[Is] ISSN:1998-3689
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:A 64-year-old male patient presented to the clinic with diminished vision in his right eye for the past 2 years. Examination revealed a best-corrected visual acuity (BCVA) of counting fingers at 1 m with a scarred choroidal neovascular membrane (CNVM) in the right eye while the left eye had a BCVA of 20/20 with a small peripapillary subretinal hemorrhage along with angioid streaks in both eyes. Multimodal imaging revealed the presence of a CNVM in the left eye which was treated with focal thermal laser. Regression was noted on optical coherence tomography angiography at 1 month post-laser, but at 3-month follow-up, exacerbation of the CNVM was observed. Subsequently, four intravitreal ziv-aflibercept injections were given, and scarring of CNVM was noted on OCT. Thermal laser in the background of angioid streaks has worsened the breaks in the Bruch's membrane leading to worsening of the CNVM.
[Pt] Publication type:CASE REPORTS
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:In-Data-Review
[do] DOI:10.4103/ijo.IJO_837_17

  2 / 646 MEDLINE  
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[PMID]: 29450330
[Au] Autor:Branisteanu DC; Bîlha A; Moraru A
[Ad] Address:Ophthalmology Department, "Gr. T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
[Ti] Title:Aflibercept efficacy in refractory choroidal neovascularization.
[So] Source:Rom J Ophthalmol;60(2):96-102, 2016 Apr-Jun.
[Is] ISSN:2457-4325
[Cp] Country of publication:Romania
[La] Language:eng
[Ab] Abstract:The aim of the report is to evaluate the short-term efficacy and safety of aflibercept (EYLEA®) in patients with choroidal neovascularization (CNV) transformed into refractory during treatment with bevacizumab (AVASTIN ®). METHODS: Clinical, morphological, and functional changes were retrospectively evaluated in cases with refractory CNVs to monthly 1.25 mg bevacizumab intravitreal injections (AVASTIN ®) and switched to 3 monthly 2.0 mg intravitreal injections of aflibercept (EYLEA ®). RESULTS: In this pilot evaluation, 8 cases of CNVs that become refractory to intravitreal treatment with 1.25 mg intravitreal bevacizumab (AVASTIN ®), were switched to 2.0 mg intravitreal aflibercept (EYLEA ®) and evaluated. The mean age of patients was 67.6 years (54-74 years). In 7 cases, CNV was associated to age related macular degeneration and in 1 case to angioid streaks. The mean number of previous intravitreal bevacizumab (AVASTIN®) administrations was 9.32 (7-12). In all cases, the last 3 intravitreal injections of bevacizumab were performed at an interval of maximum 6 weeks. The refractory status was confirmed by the lack of improvement or worsening of the clinical features as revealed by SD-OCT. A slowly anatomical improvement was noticed in 5 out of 8 cases (62.5%) since the first aflibercept administration. The anatomical improvement was stable after 3 monthly administrations. During the treatment, only 3 out of 5 cases (60%) showing anatomical improvement had a minor visual benefit (one line of VA gain). In 3 cases, the treatment change was unremarkable. No side effects were noticed. CONCLUSIONS: The anatomical improvement confirms previous reports regarding the efficacy and safety of aflibercept (EYLEA®) in some cases of CNV that became refractory during conventional anti-VEGF therapy. The improvement can be, at least partially, explained by the more complex features of aflibercept. Unfortunately, a minor visual benefit was noticed in a limited number of cases.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180222
[Lr] Last revision date:180222
[St] Status:In-Process

  3 / 646 MEDLINE  
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[PMID]: 29443807
[Au] Autor:Chiu BQ; Tsui E; Hussnain SA; Barbazetto IA; Smith RT
[Ad] Address:Department of Ophthalmology, New York University School of Medicine, New York, New York.
[Ti] Title:MULTIMODAL IMAGING OF ANGIOID STREAKS ASSOCIATED WITH TURNER SYNDROME.
[So] Source:Retin Cases Brief Rep;, 2018 Feb 13.
[Is] ISSN:1937-1578
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To report multimodal imaging in a novel case of angioid streaks in a patient with Turner syndrome with 10-year follow-up. METHODS: Case report of a patient with Turner syndrome and angioid streaks followed at Bellevue Hospital Eye Clinic from 2007 to 2017. Fundus photography, fluorescein angiography, and optical coherence tomography angiography were obtained. RESULTS: Angioid streaks with choroidal neovascularization were noted in this patient with Turner syndrome without other systemic conditions previously correlated with angioid streaks. CONCLUSION: We report a case of angioid streaks with choroidal neovascularization in a patient with Turner syndrome. We demonstrate that angioid streaks, previously associated with pseudoxanthoma elasticum, Ehlers-Danlos syndrome, Paget disease of bone, and hemoglobinopathies, may also be associated with Turner syndrome, and may continue to develop choroidal neovascularization, suggesting the need for careful ophthalmic examination in these patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180214
[Lr] Last revision date:180214
[St] Status:Publisher
[do] DOI:10.1097/ICB.0000000000000713

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[PMID]: 29395597
[Au] Autor:Mahmoud A; Abid F; Abroug N; Mbarek S; Lahmar N; Messaoud R
[Ad] Address:Service d'ophtalmologie, faculté de médecine de Monastir, université de Monastir, CHU Taher Sfar, 5100 Mahdia, Tunisie. Electronic address: Mahmoudanis8@gmail.com.
[Ti] Title:Hématome maculaire post-traumatique révélant des stries angioïdes : apport de la tomographie par cohérence optique spectral-domain (SD-OCT). [Post-traumatic macular hematoma as presenting sign of angioid streaks: Role of spectral-domain optical coherence tomography (SD-OCT)].
[So] Source:J Fr Ophtalmol;, 2018 Jan 29.
[Is] ISSN:1773-0597
[Cp] Country of publication:France
[La] Language:fre
[Pt] Publication type:LETTER
[Em] Entry month:1802
[Cu] Class update date: 180203
[Lr] Last revision date:180203
[St] Status:Publisher

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[PMID]: 29279654
[Au] Autor:Lekha T; Prasad HN; Sarwate RN; Patel M; Karthikeyan S
[Ad] Address:Department of Ophthalmology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
[Ti] Title:Intravitreal Bevacizumab for Choroidal Neovascularization Associated with Angioid Streaks: Long-term Results.
[So] Source:Middle East Afr J Ophthalmol;24(3):136-142, 2017 Jul-Sep.
[Is] ISSN:0975-1599
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:PURPOSE: The purpose of the study was to evaluate the long-term efficacy and safety of intravitreal bevacizumab (IVB) in the treatment of choroidal neovascularization (CNV) secondary to angioid streaks (AS). MATERIALS AND METHODS: Noncomparative, interventional retrospective case series involving ten patients (15 eyes) with a minimum follow-up of 25 months following IVB for AS-associated CNV. Demographic and clinical details at baseline and during follow-up were collected from patient records. Detailed clinical examination was followed by fundus fluorescein angiography and optical coherence tomography to confirm CNV. Both primary and recurrent CNVs were treated with monthly injections of IVB till the lesion stabilized. Primary outcome measures were the percentage of patients with stable or improved visual acuity (VA) and with stable or decreased central retinal thickness (CRT) at the last visit. Secondary outcome measure was the incidence of ocular and systemic complications. RESULTS: Recurrence was observed in 11 eyes (73.33%) over a mean follow-up of 57.33 months (range: 25-100). A mean number of injections administered was 5.60. VA improved or stabilized in 73.33% and deteriorated in 26.67% of eyes at the final visit. Mean CRT improved from 324.40 µm at baseline to 265.53 µm at final visit, which was statistically significant. Complications observed were ocular hypertension in one patient and thromboembolic event in another patient. CONCLUSIONS: IVB appears to be a safe and effective option to treat CNV and to preserve vision over a prolonged period. It cannot eliminate the risk of recurrent CNV indicating the need for more effective treatments to arrest this visually debilitating condition.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171229
[Lr] Last revision date:171229
[St] Status:In-Process
[do] DOI:10.4103/meajo.MEAJO_17_17

  6 / 646 MEDLINE  
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[PMID]: 28978321
[Au] Autor:Kakurai K; Hayashi M; Yamada K; Ishizaki N; Yonemoto Y; Morishita S; Kohmoto R; Sato T; Kida T; Ikeda T
[Ad] Address:Department of Ophthalmology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka, 569-8686, Japan.
[Ti] Title:A case of pseudoxanthoma elasticum with proliferative diabetic retinopathy.
[So] Source:BMC Ophthalmol;17(1):184, 2017 Oct 04.
[Is] ISSN:1471-2415
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: To report the case of a patient with pseudoxanthoma elasticum (PXE) and proliferative diabetic retinopathy (PDR), and discuss the relationship between PXE and diabetic retinopathy (DR). CASE PRESENTATION: A 47-year-old man with PXE presented with angioid streaks and DR in both eyes, and bilateral panretinal photocoagulation was performed for treatment. Vitrectomy had previously been performed in his right eye for vitreous hemorrhage due to PDR. Systemic findings included multiple, discrete, symmetrical, small yellow papules bilaterally in the axilla and inguinal region. Examination on presentation showed vitreous hemorrhage in his left eye, and vitrectomy was performed for treatment. Intraoperative findings showed fibrovascular membrane around the optic disc and vascular arcade. A mottled fundus (peau d'orange appearance) associated with angioid streaks was also present, yet there was no evident choroidal neovascularization (CNV). The postoperative course was satisfactory, and corrected visual acuity improved from 0.02 to 0.7 diopters. CONCLUSION: Despite the peau d'orange appearance in both eyes of this case, no CNV was evident. The vitreous hemorrhage was thus attributed to PDR. Moreover, we reviewed the published literature and discuss the relationship between PXE and DR.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171015
[Lr] Last revision date:171015
[St] Status:In-Process
[do] DOI:10.1186/s12886-017-0569-1

  7 / 646 MEDLINE  
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[PMID]: 28961674
[Au] Autor:Corbelli E; Carnevali A; Marchese A; Cicinelli MV; Querques L; Sacconi R; Bandello F; Querques G
[Ad] Address:*Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy; †Department of Ophthalmology, University of "Magna Graecia," Catanzaro, Italy; and ‡Department of Ophthalmology, University of Verona, Verona, Italy.
[Ti] Title:OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF ANGIOID STREAKS.
[So] Source:Retina;, 2017 Sep 27.
[Is] ISSN:1539-2864
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To analyze the optical coherence tomography angiography features of eyes affected with angioid streaks (AS) and to evaluate their ability to predict choroidal neovascularization (CNV) activity. METHODS: Angioid streaks were individuated from a pool of consecutive patients. Eyes with and without CNV were evaluated by multimodal imaging. RESULTS: Thirty-eight eyes of 19 consecutive patients diagnosed with AS were included. Thirty of 38 eyes with CNV and 8 of 38 eyes without CNV were included. In the majority of cases, CNV showed on optical coherence tomography angiography tangled appearance always associated with signs of neovascular inactivity on multimodal imaging (100%-0%, inactive-active, respectively). Choroidal neovascularization cases showing interlacing appearance were often associated with signs of neovascular activity on multimodal imaging (71.4%-28.6%, active-inactive, respectively). Optical coherence tomography angiography revealed a total of 27 AS, of which 20 appeared as a choriocapillary rarefaction, and in 7 AS, optical coherence tomography angiography choriocapillary segmentation revealed an irregular vascular network, possibly representing fibrovascular tissue over the crack-like breaks in Bruch membrane. CONCLUSION: Optical coherence tomography angiography is a noninvasive tool to detect the presence of CNV secondary to AS and to evaluate CNV activity. Optical coherence tomography angiography is able to add a novel element to the multimodal imaging characterization of AS.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170929
[Lr] Last revision date:170929
[St] Status:Publisher
[do] DOI:10.1097/IAE.0000000000001859

  8 / 646 MEDLINE  
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[PMID]: 28912966
[Au] Autor:Katagiri S; Negishi Y; Mizobuchi K; Urashima M; Nakano T; Hayashi T
[Ad] Address:Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
[Ti] Title: Gene Analysis in 20 Japanese Patients with Angioid Streaks Revealing Four Frequent and Two Novel Variants and Pseudodominant Inheritance.
[So] Source:J Ophthalmol;2017:1079687, 2017.
[Is] ISSN:2090-004X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:PURPOSE: To report the spectrum of variants in Japanese patients with angioid streaks (AS). PATIENTS AND METHODS: This was a single-center cohort study. The medical records of 20 patients with AS from 18 unrelated Japanese families were retrospectively reviewed. Screening of the gene (exons 1 to 31) was performed using PCR-based Sanger sequencing. RESULTS: Eight variants were identified as candidate disease-causing variants. These eight variants included five known variants (p.Q378X, p.R419Q, p.V848CfsX83, p.R1114C, and p.R1357W), one previously reported variant (p.N428S) of unknown significance, and two novel variants (c.1939C>T [p.H647Y] and c.3374C>T [p.S1125F]); the three latter variants were determined to be variants of significance. The following four variants were frequently identified: p.V848CfsX83 (14/40 alleles, 35.0%), p.Q378X (7/40 alleles, 17.5%), p.R1357W (6/40 alleles, 15.0%), and p.R419Q (4/40 alleles, 10.0%). The variants were identified in compound heterozygous or homozygous states in 13 of 18 probands. Two families showed a pseudodominant inheritance pattern. Pseudoxanthoma elasticum was seen in 15 of 17 patients (88.2%) who underwent dermatological examination. CONCLUSIONS: We identified disease-causing variants that were in homozygous or compound heterozygous states in 13 of 18 families (72.2%). Our results indicated that variants play a significant role in patients with AS in the Japanese population.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170917
[Lr] Last revision date:170917
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1155/2017/1079687

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[PMID]: 28893457
[Au] Autor:El Bahloul M; Chraïbi F; Aounzou S; Salam Diarra A; Abdellaoui M; Benatiya I; Tahri H
[Ad] Address:Service d'ophtalmologie, hôpital Omar Drissi, CHU Hassan II, avenue la liberté, Batha, 30110 Fès, Maroc; Faculté de médecine et de pharmacie, université Sidi Mohammed Benabdellah, 30000 Fès, Maroc. Electronic address: elbahloulmeriem@gmail.com.
[Ti] Title:Traitement par bévacizumab et évolution des néovaisseaux choroïdiens compliquant les stries angioïdes : expérience du service d'ophtalmologie du CHU Hassan II. [Treatment of choroidal noevascularization secondary to angioid streaks with bevacizumab and response: Experience of the ophthalmology department of Hassan II university hospital].
[So] Source:J Fr Ophtalmol;40(9):731-737, 2017 Nov.
[Is] ISSN:1773-0597
[Cp] Country of publication:France
[La] Language:fre
[Ab] Abstract:PURPOSE: To evaluate the efficacy of intravitreal bevacizumab in the treatment of choroidal neovascularization (CNV) secondary to angioid streaks. METHODS: We conducted a prospective study in the ophthalmology department of Hassan II university hospital in Fez, including 12 eyes of 7 patients with CNV associated with angioid streaks. We injected 8 eyes with bevacizumab 1.25mg; best corrected visual acuity (BCVA), fundus examination, fluorescein angiography and optical coherence tomography were performed and analyzed for all patients before and after treatment. The goal of the study was to determine the percentage of patients with stabilization or improvement in BCVA and decreased central macular thickness. RESULTS: Visual acuity on admission was <1/10 in 75% of patients. We injected 8 eyes with anti-VEGF, whereas abstention was appropriate for 4 eyes with disciform scarring. The average number of bevacizumab injections was 4.3±1.3 over a mean follow-up of 14.57 months±5.3. After treatment, BCVA was <1/10 in 12.5% of cases, between 1/10 and 5/10 in 50% of cases, and in 37.5% of patients, it was ≥5/10. Mean central macular thickness decreased from 424.25±137.03µm on admission to 255.75 microns±50.14 post-treatment (P=0.005). CONCLUSION: Intravitreal bevacizumab is a promising and effective treatment option for the management of CNV associated with angioid streaks, with the requirement however of early treatment and extended follow-up.
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171105
[Lr] Last revision date:171105
[St] Status:In-Process

  10 / 646 MEDLINE  
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[PMID]: 28724827
[Au] Autor:Tugcu BL; Sezer T; Elbay A; Özdemir H
[Ad] Address:Department of Ophthalmology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
[Ti] Title:Angioid streaks in a case of Camurati-Engelmann disease.
[So] Source:Indian J Ophthalmol;65(7):628-630, 2017 Jul.
[Is] ISSN:1998-3689
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Camurati-Engelmann disease (CED) is a rare autosomal dominant disease with various phenotypic expressions. The hallmark of the disease is bilateral symmetric diaphyseal hyperostosis of the long bones with progressive involvement of the metaphysis. Ocular manifestations occur rarely and mainly result from bony overgrowth of the orbit and optic canal stenosis. We report a case of CED showing angioid streaks (ASs) in both fundi with no macular involvement and discuss the possible theories of the pathogenesis of AS in this disease.
[Mh] MeSH terms primary: Angioid Streaks/etiology
Camurati-Engelmann Syndrome/complications
Retina/pathology
[Mh] MeSH terms secundary: Adult
Angioid Streaks/diagnosis
Camurati-Engelmann Syndrome/diagnosis
Female
Fluorescein Angiography
Fundus Oculi
Humans
Tomography, Optical Coherence
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171109
[Lr] Last revision date:171109
[Js] Journal subset:IM
[Da] Date of entry for processing:170721
[St] Status:MEDLINE
[do] DOI:10.4103/ijo.IJO_910_16


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