Database : MEDLINE
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[PMID]: 29378067
[Au] Autor:Volobaev VP; Larionov AV; Kalyuzhnaya EE; Serdyukova ES; Yakovleva S; Druzhinin VG; Babich OO; Hill EG; Semenihin VA; Panev NI; Minina VI; Sivanesan SD; Naoghare P; da Silva J; Barcelos GRM; Prosekov AY
[Ad] Address:Department of Genetics, Kemerovo State University, Russian Federation.
[Ti] Title:Associations of polymorphisms in the cytokine genes IL1ß (rs16944), IL6 (rs1800795), IL12b (rs3212227) and growth factor VEGFA (rs2010963) with anthracosilicosis in coal miners in Russia and related genotoxic effects.
[So] Source:Mutagenesis;, 2018 Jan 25.
[Is] ISSN:1464-3804
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Anthracosilicosis (AS), a prevalent form of pneumoconiosis among coal miners, results from the accumulation of carbon and silica in the lungs from inhaled coal dust. This study investigated genotoxic effects and certain cytokine genes polymorphic variants in Russian coal miners with АS. Peripheral leukocytes were sampled from 129 patients with AS confirmed by X-ray and tissue biopsy and from 164 asymptomatic coal miners. Four single-nucleotide polymorphisms were genotyped in the extracted DNA samples: IL1ß T-511C (rs16944), IL6 C-174G (rs1800795), IL12b A1188C (rs3212227) and VEGFA C634G (rs2010963). Genotoxic effects were assessed by the analysis of chromosome aberrations in cultured peripheral lymphocytes. The mean frequency of chromatid-type aberrations and chromosome-type aberrations, namely, chromatid-type breaks and dicentric chromosomes, was found to be higher in AS patients [3.70 (95% confidence interval {CI}, 3.29-4.10) and 0.28 (95% CI, 0.17-0.38)] compared to the control group [2.41 (95% CI, 2.00-2.82) and 0.09 (95% CI, 0.03-0.15)], respectively. IL1ß gene T/T genotype (rs16944) was associated with AS [17.83% in AS patients against 4.35% in healthy donors, odds ratio = 4.77 (1.88-12.15), P < 0.01]. A significant increase in the level of certain chromosome interchanges among AS donors is of interest because such effects are typical for radiation damage and caused by acute oxidative stress. IL1ß T allele probably may be considered as an AS susceptibility factor among coal miners.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180129
[Lr] Last revision date:180129
[St] Status:Publisher
[do] DOI:10.1093/mutage/gex047

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[PMID]: 28806260
[Au] Autor:McGuiness M; Sounness B
[Ad] Address:From the *Department of Nuclear Medicine, Gold Coast University Hospital, Southport, Queensland Australia; †South Coast Radiology.
[Ti] Title:68Ga-PSMA-Ligand PET/CT Uptake in Anthracosilicosis.
[So] Source:Clin Nucl Med;42(10):e431-e432, 2017 Oct.
[Is] ISSN:1536-0229
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:This interesting image illustrates a case of biopsy-proven pulmonary anthracosilicosis, a mixed dust pneumoconiosis, associated with Ga-PSMA-ligand uptake. Prostate-specific membrane antigen (PSMA) is an emerging imaging biomarker, with clinical application in evaluation of prostate cancer using Ga-PSMA-ligand PET/CT. Contrary to its name, PSMA is expressed in a number of other normal tissues and pathological states. Prostate-specific membrane antigen expression has been linked to tumor angiogenesis in various other epithelial neoplasms, as well as neovasculature associated with tissue regeneration and repair. Awareness of nonneoplastic inflammatory conditions associated with Ga-PSMA-ligand uptake aids in patient assessment and management.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170905
[Lr] Last revision date:170905
[St] Status:In-Process
[do] DOI:10.1097/RLU.0000000000001782

  3 / 396 MEDLINE  
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[PMID]: 28689212
[Au] Autor:Jelic TM; Estalilla OC; Sawyer-Kaplan PR; Plata MJ; Powers JT; Emmett M; Kuenstner JT
[Ad] Address:Department of Pathology and Laboratory Medicine, Charleston Area Medical Center, Charleston, 3200 MacCorkle Ave, Charleston WV 25304, USA. tjelic@suddenlink.net.
[Ti] Title:Coal Mine Dust Desquamative Chronic Interstitial Pneumonia: A Precursor of Dust-Related Diffuse Fibrosis and of Emphysema.
[So] Source:Int J Occup Environ Med;8(3):153-165, 2017 07.
[Is] ISSN:2008-6814
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:BACKGROUND: Diseases associated with coal mine dust continue to affect coal miners. Elucidation of initial pathological changes as a precursor of coal dust-related diffuse fibrosis and emphysema, may have a role in treatment and prevention. OBJECTIVE: To identify the precursor of dust-related diffuse fibrosis and emphysema. METHODS: Birefringent silica/silicate particles were counted by standard microscope under polarized light in the alveolar macrophages and fibrous tissue in 25 consecutive autopsy cases of complicated coal worker's pneumoconiosis and in 21 patients with tobacco-related respiratory bronchiolitis. RESULTS: Coal miners had 331 birefringent particles/high power field while smokers had 4 (p<0.001). Every coal miner had intra-alveolar macrophages with silica/silicate particles and interstitial fibrosis ranging from minimal to extreme. All coal miners, including those who never smoked, had emphysema. Fibrotic septa of centrilobular emphysema contained numerous silica/silicate particles while only a few were present in adjacent normal lung tissue. In coal miners who smoked, tobacco-associated interstitial fibrosis was replaced by fibrosis caused by silica/silicate particles. CONCLUSION: The presence of silica/silicate particles and anthracotic pigment-laden macrophages inside the alveoli with various degrees of interstitial fibrosis indicated a new disease: coal mine dust desquamative chronic interstitial pneumonia, a precursor of both dust-related diffuse fibrosis and emphysema. In studied coal miners, fibrosis caused by smoking is insignificant in comparison with fibrosis caused by silica/silicate particles. Counting birefringent particles in the macrophages from bronchioalveolar lavage may help detect coal mine dust desquamative chronic interstitial pneumonia, and may initiate early therapy and preventive measures.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170916
[Lr] Last revision date:170916
[St] Status:In-Process
[do] DOI:10.15171/ijoem.2017.1066

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[PMID]: 27478398
[Au] Autor:Jungraithmayr W; Tzafos S; Distler O; Kolios AG; Weder W; Franzen D
[Ad] Address:Division of Thoracic Surgery, University Hospital Zurich, Raemistr. 100, 8091 Zurich, Switzerland.
[Ti] Title:Rapid Growth of Lung Nodules due to Combined Pulmonary Vasculitis, Silicoanthracosis, and Chondrocalcinosis.
[So] Source:Can Respir J;2016:9254374, 2016.
[Is] ISSN:1916-7245
[Cp] Country of publication:Egypt
[La] Language:eng
[Ab] Abstract:Background. Silicoanthracosis is a pneumoconiosis due to occupational inhalation of silica and carbon dusts. Clinically, it can be associated with vasculitis or rheumatoid arthritis. In association with these diseases, silicoanthracosis can present within the lung with multiple pulmonary nodules which, as a differential diagnosis, can mimic metastatic disease or multiple abscesses. Case Presentation. We present the case of a 62-year old former pit worker with pulmonary nodules, chondrocalcinosis due to calcium pyrophosphate deposition (CPPD), and a history of renal cancer. Within a short period of time, pulmonary nodules grew rapidly. Thoracoscopically, the resected lung specimen revealed silicoanthracosis associated with small-to-medium-size vasculitis in the presence of antineutrophil cytoplasmatic autoantibodies (c-ANCA). Conclusion. Pulmonary silicoanthracotic lesions on the base of ANCA-associated vasculitis and CPPD arthritis can rapidly grow. A mutual correlation between silicoanthracosis, ANCA-associated vasculitis, and CPPD seems possible. Apart from this, consideration of metastatic disease should be obligatory in patients with a history of cancer at the same time being immunosuppressed.
[Mh] MeSH terms primary: Anthracosilicosis/complications
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications
Arthritis/complications
Chondrocalcinosis/complications
Multiple Pulmonary Nodules/complications
[Mh] MeSH terms secundary: Anthracosilicosis/diagnostic imaging
Anthracosilicosis/pathology
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnostic imaging
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/pathology
Antirheumatic Agents/therapeutic use
Arthritis/drug therapy
Chondrocalcinosis/diagnostic imaging
Chondrocalcinosis/drug therapy
Chondrocalcinosis/pathology
Humans
Immunologic Factors/therapeutic use
Lung/diagnostic imaging
Lung/pathology
Male
Methotrexate/therapeutic use
Middle Aged
Multiple Pulmonary Nodules/diagnostic imaging
Multiple Pulmonary Nodules/pathology
Rituximab/therapeutic use
Thoracoscopy
Tomography, X-Ray Computed
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Antirheumatic Agents); 0 (Immunologic Factors); 4F4X42SYQ6 (Rituximab); YL5FZ2Y5U1 (Methotrexate)
[Em] Entry month:1707
[Cu] Class update date: 170817
[Lr] Last revision date:170817
[Js] Journal subset:IM
[Da] Date of entry for processing:160802
[St] Status:MEDLINE
[do] DOI:10.1155/2016/9254374

  5 / 396 MEDLINE  
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[PMID]: 26957815
[Au] Autor:Spalgais S; Gothi D; Jaiswal A; Gupta K
[Ad] Address:Department of Pulmonary Medicine, ESI-PGIMSR, Delhi, India.
[Ti] Title:Nonoccupational anthracofibrosis/anthracosilicosis from Ladakh in Jammu and Kashmir, India: A case series.
[So] Source:Indian J Occup Environ Med;19(3):159-66, 2015 Sep-Dec.
[Is] ISSN:0973-2284
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:BACKGROUND: Nonoccupational anthracosis and silicosis has been reported from various parts of the world including Ladakh in Jammu and Kashmir, India; however, anthracosilicosis has only been reported in industrial workers till date. MATERIALS AND METHODS: Six cases from the Ladakh region in Jammu and Kashmir, India with similar clinico-radiological-pathological features, i.e., anthracosilicosis/anthracofibrosis have been analyzed. Of these, four were analyzed retrospectively and two prospectively. RESULT: All the patients were homemakers and resided in Ladakh in Jammu and Kashmir, India since birth with an age range of 42-62 years and an average age of 56 years. Their average duration of symptoms was 4 years. Spirometry showed small and/or large airway disease in 5/6 cases. On computed tomography (CT), 4/6 cases showed progressive massive fibrosis (PMF) with calcified mediastinal lymph nodes. There were random or centrilobular nodules in all the six cases. Bronchoscopy in 5/6 cases showed multiple anthracotic pigments with narrowing and distortion of the bronchus (anthracofibrosis). Malignancy was suspected clinico-radiologically in four cases and pathologically in two cases. On histopathology, anthracosis was demonstrated in all and silicosis in three cases. CONCLUSION: Anthracosilicosis can occur due to environmental exposure. Ladakh in Jammu and Kashmir, India is the only place across the globe with unique environmental features having the presence of both free silica and biomass fuel. The disease was observed predominantly in older women. Awareness would prevent unnecessary investigation for malignancy. Treatment with the bronchodilator is useful as it has evidence of airway disease. Finally, environmental measures and a proper study need to be undertaken for knowing the relative role of silica versus soot in causing the lung disease and preventing this irreversible condition.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1603
[Cu] Class update date: 170220
[Lr] Last revision date:170220
[Da] Date of entry for processing:160310
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/0019-5278.173995

  6 / 396 MEDLINE  
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[PMID]: 26388578
[Au] Autor:Zakharenkov VV; Mikhailova NN; Zhdanova NN; Gorokhova LG; Zhukova AG
[Ad] Address:Research Institute of Problems of Hygiene and Occupational Diseases, Siberian Division of the Russian Academy of Medical Sciences, Novokuznetsk, Russia.
[Ti] Title:Experimental Study of the Mechanisms of Intracellular Defense in Cardiomyocytes Associated with Stages of Anthracosilicosis Development.
[So] Source:Bull Exp Biol Med;159(4):431-4, 2015 Aug.
[Is] ISSN:1573-8221
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Mechanisms of intracellular defense of rat cardiomyocytes were studied in dynamics of anthracosilicosis development induced by long-term inhalation of coal and rock dust. It was shown that synthesis of transcription factor HIF-1α and protective proteins increased in the heart at the early stages of coal and rock dust inhalation (1-3 weeks), and these changes limited the development of free radical oxidation and activated metabolism of glucose and fatty acids. Exposure to coal and rock dust for 6-12 weeks activated free radical oxidation and decreased basal metabolism in cardiomyocytes.
[Mh] MeSH terms primary: Anthracosilicosis/pathology
Myocytes, Cardiac/metabolism
[Mh] MeSH terms secundary: Animals
HSP72 Heat-Shock Proteins/metabolism
Heme Oxygenase (Decyclizing)/metabolism
Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
Male
Myocardium/metabolism
Oxidation-Reduction
Protective Factors
Rats, Wistar
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (HSP72 Heat-Shock Proteins); 0 (Hif1a protein, rat); 0 (Hypoxia-Inducible Factor 1, alpha Subunit); EC 1.14.14.18 (Heme Oxygenase (Decyclizing)); EC 1.14.14.18 (heme oxygenase-2)
[Em] Entry month:1607
[Cu] Class update date: 161125
[Lr] Last revision date:161125
[Js] Journal subset:IM
[Da] Date of entry for processing:150922
[St] Status:MEDLINE
[do] DOI:10.1007/s10517-015-2983-9

  7 / 396 MEDLINE  
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[PMID]: 25563541
[Au] Autor:Halldin CN; Reed WR; Joy GJ; Colinet JF; Rider JP; Petsonk EL; Abraham JL; Wolfe AL; Storey E; Laney AS
[Ad] Address:From the Surveillance Branch (Dr Halldin, Dr Petsonk, Ms Wolfe, Dr Storey, and Dr Laney), Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WVa; Office of Mine Safety and Health Research (Dr Reed, Mr Joy, Mr Colinet, and Mr Rider), National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Pittsburgh, Penn; and Department of Pathology (Dr Abraham), State University of New York Upstate Medical University, Syracuse.
[Ti] Title:Debilitating lung disease among surface coal miners with no underground mining tenure.
[So] Source:J Occup Environ Med;57(1):62-7, 2015 Jan.
[Is] ISSN:1536-5948
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To characterize exposure histories and respiratory disease among surface coal miners identified with progressive massive fibrosis from a 2010 to 2011 pneumoconiosis survey. METHODS: Job history, tenure, and radiograph interpretations were verified. Previous radiographs were reviewed when available. Telephone follow-up sought additional work and medical history information. RESULTS: Among eight miners who worked as drill operators or blasters for most of their tenure (median, 35.5 years), two reported poor dust control practices, working in visible dust clouds as recently as 2012. Chest radiographs progressed to progressive massive fibrosis in as few as 11 years. One miner's lung biopsy demonstrated fibrosis and interstitial accumulation of macrophages containing abundant silica, aluminum silicate, and titanium dust particles. CONCLUSIONS: Overexposure to respirable silica resulted in progressive massive fibrosis among current surface coal miners with no underground mining tenure. Inadequate dust control during drilling/blasting is likely an important etiologic factor.
[Mh] MeSH terms primary: Anthracosilicosis/complications
Coal Mining
Lung Neoplasms/diagnostic imaging
Occupational Exposure/analysis
Pulmonary Fibrosis/diagnostic imaging
Pulmonary Fibrosis/pathology
[Mh] MeSH terms secundary: Coal Mining/methods
Humans
Interviews as Topic
Male
Middle Aged
Occupational Exposure/adverse effects
Occupations
Pulmonary Fibrosis/etiology
Radiography
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Em] Entry month:1509
[Cu] Class update date: 161125
[Lr] Last revision date:161125
[Js] Journal subset:IM
[Da] Date of entry for processing:150108
[St] Status:MEDLINE
[do] DOI:10.1097/JOM.0000000000000302

  8 / 396 MEDLINE  
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[PMID]: 25881398
[Au] Autor:Panev NI; Korotenko OIu; Zakharenkov VV; Korchagina IuS; Gafarov NI
[Ti] Title:[Diagnosis of predisposition to chronic cor pulmonale formation in occupational lung diseases caused by dust].
[So] Source:Med Tr Prom Ekol;(10):35-9, 2014.
[Is] ISSN:1026-9428
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:Study covered 426 miners aged 40-54 years with previously diagnosed occupational respiratory diseases due to dust (246 patients with chronic occupational obstructive bronchitis, 98 with anthracosilicosis and 82 with chronic dust nonobstructive bronchitis). 315 (73.9%) examinees out of 426 with lung diseases due to dust demonstrated chronic cor pulnmonale. Considering high share of this complication, the authors used Bayes method to create a method to diagnose predisposition towards chronic cor pulmonale in patients with dust lung diseases through respiratory failure, concomitant coronary heart disease and arterial hypertension, blood groups ABO, MN and P, some structural and functional parameters of heart: myocardium weight index, relative wall thickness index and left ventricle sphericity index, average lung artery pressure. Increasing number of analyzed factors that directly influence chronic cor pulmonale development and selecting additional markers help to improve forecasting of the complication.
[Mh] MeSH terms primary: Disease Susceptibility/diagnosis
Lung Diseases/complications
Occupational Diseases/complications
Occupational Exposure/adverse effects
Pulmonary Heart Disease/etiology
[Mh] MeSH terms secundary: Adult
Dust
Humans
Lung Diseases/etiology
Male
Middle Aged
Mining
Occupational Diseases/etiology
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Name of substance:0 (Dust)
[Em] Entry month:1505
[Cu] Class update date: 150417
[Lr] Last revision date:150417
[Js] Journal subset:IM
[Da] Date of entry for processing:150418
[St] Status:MEDLINE

  9 / 396 MEDLINE  
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[PMID]: 25073334
[Au] Autor:Piktushanskaia TE
[Ti] Title:[Contemporary features of pneumoconiosis formation and course in miners of East Donbass].
[So] Source:Med Tr Prom Ekol;(2):10-4, 2014.
[Is] ISSN:1026-9428
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:The author analyzed dynamics and structure of occupational morbidity including pneumoconiosis in Rostov region of Russian Federation, since 1990 until now. They were compared with analogous parameters of previous historical period. Findings are that contemporary dynamics of anthracosilicosis clinical features is characterized by severily reduced terms of the disease development from medical registration of the diseased miner, earlier addition of malignancy, respiratory failure and other complications--that in aggregate causes earlier disablement and drastically reduced survival rate in occupational patients with anthracosilicosis.
[Mh] MeSH terms primary: Anthracosilicosis/epidemiology
Coal Mining/statistics & numerical data
Disease Progression
Mass Screening/statistics & numerical data
Occupational Diseases/epidemiology
Occupational Health Services/statistics & numerical data
[Mh] MeSH terms secundary: Adult
Anthracosilicosis/etiology
Humans
Male
Mass Screening/standards
Occupational Health Services/standards
Russia/epidemiology
[Pt] Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1408
[Cu] Class update date: 140730
[Lr] Last revision date:140730
[Js] Journal subset:IM
[Da] Date of entry for processing:140731
[St] Status:MEDLINE

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[PMID]: 24550186
[Au] Autor:Martínez-Girón R; Martínez-Torre S; Tamargo-Peláez ML; López-Cabanilles MD; Torre-Bayón C
[Ad] Address:CFGS Anatomía Patológica y Citología, Instituto de Piedras Blancas, Asturias, Spain; Fundación INCLÍNICA, Oviedo, Spain.
[Ti] Title:Calcareous concretions and psammoma bodies in sputum smears: do these similar structures have different clinical significance?
[So] Source:Diagn Cytopathol;42(9):759-65, 2014 Sep.
[Is] ISSN:1097-0339
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Different noncellular elements, such as round concentric calcified laminated structures, may be found in sputum smears. If these structures appear isolated on the background of the smear, the term usually used to describe them is "calcareous concretions" (CC). On the contrary, when the structures are part of epithelial cell groups or small tissue fragments, the term used to describe them is "Psammoma bodies" (PB). The aim of this work is to establish the relationship between these structures and pulmonary disease, especially lung carcinoma, by searching for the presence of CC and/or PB in sputum smears. Our study has taken as a basis 16.716 sputum smears from 696 patients obtained during a 7-year period (2003-2009). After reviewing them, it was found that from the total, 66 cases (0.39%) contained round calcified structures, 57 of them (0.34%) corresponding to CC, and the remaining 9 ones (0.05%) corresponding to PB. From these 57 CC cases, 56 corresponded to benign entities, and only one was found with lung carcinoma. On the other hand, from the 9 PB cases all of them (100%) were related to lung adenocarcinoma. We conclude that, even having a similar morphological structure, these aforementioned calcified structures we have observed in sputum smears have different and relevant clinical significance.
[Mh] MeSH terms primary: Adenocarcinoma/pathology
Anthracosilicosis/pathology
Inclusion Bodies/pathology
Lung Diseases, Obstructive/pathology
Lung Neoplasms/pathology
Papanicolaou Test
Sputum/cytology
[Mh] MeSH terms secundary: Adult
Aged
Aged, 80 and over
Calcinosis
Epithelial Cells/pathology
Female
Humans
Male
Middle Aged
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Cu] Class update date: 140723
[Lr] Last revision date:140723
[Js] Journal subset:IM
[Da] Date of entry for processing:140220
[St] Status:MEDLINE
[do] DOI:10.1002/dc.23120


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