Database : MEDLINE
Search on : Anthraquinones [Words]
References found : 6898 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 690 go to page                         

  1 / 6898 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 29520909
[Au] Autor:El-Saied MA; Sobeh M; Abdo W; Badr OM; Youssif LT; Elsayed IH; Osman SM; Wink M
[Ad] Address:Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Sadat City, Menoufia Province, Egypt.
[Ti] Title:Rheum palmatum root extract inhibits hepatocellular carcinoma in rats treated with diethylnitrosamine.
[So] Source:J Pharm Pharmacol;, 2018 Mar 09.
[Is] ISSN:2042-7158
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:OBJECTIVES: The aim of this study was to investigate the potential anticancer properties of a methanol extract of Rheum palmatum roots against diethylnitrosamine (DENA)-induced hepatocellular carcinoma (HCC) in rats and to characterize its phytoconstituents. METHODS: HPLC-PDA-MS/MS was used to profile the secondary metabolites in R. palmatum root extract. HCC was induced using diethylnitrosamine (DENA). The activity of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT), alpha-fetoprotein (AFP), total proteins, serum albumin and serum globulin was determined. DNA fragmentation and histopathological examination and GST-P immunostaining were also studied. KEY FINDINGS: LC-MS/MS analysis identified 16 compounds belonging to anthraquinones, flavonoids and tannins. The root extract significantly reduced the elevated liver enzymes ALT and AST and increased total proteins, albumin and globulin in HCC-rats. Also, the tumour markers AFP and GGT levels were significantly reduced in HCC-rats treated with the extract. In addition, the extract significantly reduced elevated DNA fragmentation and decreased the numbers and areas of GST-P positive putative foci in HCC-rats. CONCLUSIONS: Rheum palmatum is a potential candidate to be explored for the treatment of hepatocellular carcinoma.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher
[do] DOI:10.1111/jphp.12899

  2 / 6898 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29376349
[Au] Autor:Zhao Y; Wang M; Zhou P; Yang S; Liu Y; Yang C; Yang Y
[Ad] Address:School of Physics and Optoelectronics Engineering , Ludong University , Yantai 264025 , China.
[Ti] Title:Mechanism of Fluorescence Quenching by Acylamino Twist in the Excited State for 1-(Acylamino)anthraquinones.
[So] Source:J Phys Chem A;, 2018 Mar 08.
[Is] ISSN:1520-5215
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Nitrogen-containing anthraquinone derivatives are widely applied in vegetable fiber dyes. In this paper, the fluorescence quenching mechanism by an acylamino group twist in the excited state for the 1-(acylamino)anthraquinones (AYAAQs) derivatives in acetonitrile is investigated by density functional theory (DFT) and time-dependent density functional theory (TD-DFT) methods. The calculated Stokes shift is in good agreement with the experimental data. The energy profiles show that each AYAAQs derivative reveals a barrierless twist process, indicating that the involvement of acylamino group rotation in addition to proton transfer becomes as another important coordinate in the excited state relaxation pathway. The effects of electron-substituted group promote twist process compared with 1-aminoanthraquinone (AAQ). Then, the cross points are searched by the constructed linearly interpolated internal coordinate (LIIC) pathways for AYAAQs, demonstrating that the potential energy curves of the S and T states intersect each other and are in accord with the El-Sayed rules. So one can conclude that the acylamino group twist and following intersystem crossing (ISC) processes are important nonradiative inactivation channel for the S state of the AYAAQs derivatives, which is more prone to proton transfer process and can explain the low fluorescence efficiency. In addition, we have measured the phosphorescence spectra of AAQ, and on this basis, it can be predicted that the phosphorescence may occur for the AYAAQs derivatives.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[St] Status:Publisher
[do] DOI:10.1021/acs.jpca.7b11675

  3 / 6898 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
SciELO Brazil full text

[PMID]: 29267673
[Au] Autor:Yan Y; Qi S; Gong SQ; Shang G; Zhao Y
[Ad] Address:Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Department of Pediatric Dentistry, Shanghai, China.
[Ti] Title:Effect of CRABP2 on the proliferation and odontoblastic differentiation of hDPSCs.
[So] Source:Braz Oral Res;31:e112, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:Cellular retinoic acid-binding protein 2 (CRABP2) has been detected in several organs during embryonic development. Recent studies have demonstrated that CRABP2 plays important roles in the retinoic acid, ß-catenin and Notch signaling pathways, as well as in the interaction between epithelial and mesenchymal cells, which are important for human dental pulp stem cells (hDPSCs) and tooth development. In the present study, the expression of CRABP2 during mouse molar development and the role of CRABP2 in hDPSC odontoblastic differentiation were evaluated. CRABP2 was gradually decreased during the development of the first maxillary molar, which exhibited the same trend as the expression of CRABP2 during the odontoblastic induction of hDPSCs. CRABP2 knockdown inhibited the proliferative ability of hDPSCs, while it enhanced odontoblastic differentiation via promoting mineralization nodule formation and upregulating the activity of alkaline phosphatase and the expression of mineralization-related genes. The present study uncovered a novel function of CRABP2 in hDPSCs. Our data suggest that CRABP2 may act as a regulator during the proliferation and differentiation of hDPSCs.
[Mh] MeSH terms primary: Cell Differentiation/physiology
Cell Proliferation/physiology
Dental Pulp/cytology
Odontoblasts/physiology
Receptors, Retinoic Acid/physiology
Stem Cells/physiology
[Mh] MeSH terms secundary: Alkaline Phosphatase
Analysis of Variance
Animals
Anthraquinones
Blotting, Western
Cell Communication
Cells, Cultured
Coloring Agents
Down-Regulation/physiology
Female
Humans
Immunohistochemistry
Male
Mice, Inbred C57BL
Receptors, Retinoic Acid/analysis
Reference Values
Reverse Transcriptase Polymerase Chain Reaction
Time Factors
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anthraquinones); 0 (Coloring Agents); 0 (Receptors, Retinoic Acid); 0 (retinoic acid binding protein II, cellular); 60MEW57T9G (alizarin); EC 3.1.3.1 (Alkaline Phosphatase)
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:D; IM
[Da] Date of entry for processing:171222
[St] Status:MEDLINE

  4 / 6898 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Costa, Carlos Alberto de Souza
SciELO Brazil full text

[PMID]: 29267665
[Au] Autor:Leite MLAES; Soares DG; Basso FG; Hebling J; Costa CAS
[Ad] Address:Universidade Estadual Paulista "Júlio de Mesquita Filho" - Unesp, School of Dentistry, Department of Dental Materials and Prosthodontics, Araraquara, SP, Brazil.
[Ti] Title:Biostimulatory effects of simvastatin on MDPC-23 odontoblast-like cells.
[So] Source:Braz Oral Res;31:e104, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] Country of publication:Brazil
[La] Language:eng
[Ab] Abstract:The aim of this study was to evaluate the bioactivity and cytocompatibility of simvastatin (SV) applied to MDPC-23 odontoblast-like cells. For this purpose, MDPC-23 cells were seeded in 96-well plates and submitted to treatments with 0.01 or 0.1 µM of SV for 24 h, 72 h or continuously throughout the experimental protocol. The negative control group (NC) was maintained in DMEM. Cell viability (MTT), ALP activity (thymolphthalein monophosphate), and mineralized matrix deposition (alizarin red) were analyzed at several time points. The data were submitted to ANOVA and Tukey's test (α = 0.05). Although cell viability was observed in the groups treated with SV, these groups did not differ from the NC up to 7 days. There was a reduction in cell viability for the groups treated with 0.1 µM of SV for 72 h, and submitted to continuous mode after 14 days. A significant increase in ALP activity occurred in the group treated with 0.01 µM of SV for 24 h, compared with the NC; however, only the group treated with 0.1 µM of SV in continuous mode reduced the ALP activity, in comparison with the NC. After 14 days, only continuous treatment with 0.1 µM of SV did not differ from NC, whereas the other experimental groups showed increased mineralized matrix deposition. Thus, it was concluded that low concentrations of simvastatin were bioactive and cytocompatible when applied for short periods to cultured MDPC-23 odontoblast-like cells.
[Mh] MeSH terms primary: Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology
Odontoblasts/drug effects
Simvastatin/pharmacology
[Mh] MeSH terms secundary: Animals
Anthraquinones
Cell Line
Cell Survival/drug effects
Rats
Reference Values
Thymolphthalein/analogs & derivatives
Thymolphthalein/analysis
Time Factors
[Pt] Publication type:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Name of substance:0 (Anthraquinones); 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors); 17016-43-2 (thymolphthalein monophosphate); 60MEW57T9G (alizarin); AGG2FN16EV (Simvastatin); YG5I28WSQP (Thymolphthalein)
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:D; IM
[Da] Date of entry for processing:171222
[St] Status:MEDLINE

  5 / 6898 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 28946118
[Au] Autor:Rybczynska-Tkaczyk K; Swiecilo A; Szychowski KA; Kornillowicz-Kowalska T
[Ad] Address:Department of Environmental Microbiology, Laboratory of Mycology, The University of Life Sciences, Leszczynskiego Street 7, Lublin 20-069, Poland. Electronic address: kamila.rybczynska-tkaczyk@up.lublin.pl.
[Ti] Title:Comparative study of eco- and cytotoxicity during biotransformation of anthraquinone dye Alizarin Blue Black B in optimized cultures of microscopic fungi.
[So] Source:Ecotoxicol Environ Saf;147:776-787, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:The aim of this study was to select optimal conditions (C and N sources, initial pH and temperature) for biodecolorization of 0.03% anthraquinone dye Alizarin Blue Black B (ABBB) by microscopic fungi: Haematonectria haematococca BwIII43, K37 and Trichoderma harzianum BsIII33. The phenolic compounds, phytotoxicity (Lepidium sativum L.), biotoxicity (Microtox), cytotoxicity and yeast viability assay were performed to determine the extent of ABBB detoxification. Biodecolorization and detoxification of 0.03% ABBB in H. haematococca BwIII43 and T. harzianum BsIII33 cultures was correlated with extracellular oxidoreductases activity. In turn, secondary products, toxic to human fibroblasts and respiring sod1 Saccharomyces cerevisiae cells, were formed in H. haematococca K37 strain cultures, despite efficient decolorization.
[Mh] MeSH terms primary: Anthraquinones/toxicity
Coloring Agents/toxicity
Water Pollutants, Chemical/toxicity
Water Purification/methods
Yeasts/metabolism
[Mh] MeSH terms secundary: Anthraquinones/analysis
Biodegradation, Environmental
Biotransformation
Cell Line
Cell Survival/drug effects
Coloring Agents/analysis
Humans
Lepidium sativum/drug effects
Oxidation-Reduction
Toxicity Tests/methods
Water Pollutants, Chemical/analysis
Yeasts/drug effects
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Name of substance:0 (Anthraquinones); 0 (Coloring Agents); 0 (Water Pollutants, Chemical)
[Em] Entry month:1803
[Cu] Class update date: 180308
[Lr] Last revision date:180308
[Js] Journal subset:IM
[Da] Date of entry for processing:170926
[St] Status:MEDLINE

  6 / 6898 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29506390
[Au] Autor:Vyas P; Yadav DK; Khandelwal P
[Ad] Address:a Department of Chemistry , Mohanlal Sukhadia University , Udaipur , India.
[Ti] Title:Tectona grandis (teak) - A review on its phytochemical and therapeutic potential.
[So] Source:Nat Prod Res;:1-17, 2018 Mar 06.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Tectona grandis Linn (Teak), is locally known as Sagwan, belongs to Lamiaceae family. It is one of the most valuable timber in the world, due to its beautiful surface and its resistance to termite and fungal damage. The main active ingredient compounds that are responsible for these action are tectoquinone, lapachol and deoxylapachol. Naphthoquinones, anthraquinones and isoprenoid quinones are abundant metabolites in teak. In addition to these, teak contains several other phytochemicals such as triterpenoids, steroids, lignans, fatty esters and phenolic compounds. Pharmacologically, the plant has been investigated for antioxidant, anti-inflammatory, anti-pyretic, cytotoxic, analgesic, hypoglycemic, wound healing and antiplasmodial activities. The present review highlights the phytochemical and pharmacological aspects of teak.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180306
[Lr] Last revision date:180306
[St] Status:Publisher
[do] DOI:10.1080/14786419.2018.1440217

  7 / 6898 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29374471
[Au] Autor:Abu N; Zamberi NR; Yeap SK; Nordin N; Mohamad NE; Romli MF; Rasol NE; Subramani T; Ismail NH; Alitheen NB
[Ad] Address:UKM Molecular Biology Institute (UMBI), UKM Medical Center, Jalan Yaacob Latif, Bandar Tun Razak 56000 Cheras, Kuala Lumpur, Malaysia.
[Ti] Title:Subchronic toxicity, immunoregulation and anti-breast tumor effect of Nordamnacantal, an anthraquinone extracted from the stems of Morinda citrifolia L.
[So] Source:BMC Complement Altern Med;18(1):31, 2018 Jan 27.
[Is] ISSN:1472-6882
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Morinda citrifolia L. that was reported with immunomodulating and cytotoxic effects has been traditionally used to treat multiple illnesses including cancer. An anthraquinone derived from fruits of Morinda citrifolia L., nordamnacanthal, is a promising agent possessing several in vitro biological activities. However, the in vivo anti-tumor effects and the safety profile of nordamnacanthal are yet to be evaluated. METHODS: In vitro cytotoxicity of nordamnacanthal was tested using MTT, cell cycle and Annexin V/PI assays on human MCF-7 and MDA-MB231 breast cancer cells. Mice were orally fed with nordamnacanthal daily for 28 days for oral subchronic toxicity study. Then, the in vivo anti-tumor effect was evaluated on 4T1 murine cancer cells-challenged mice. Changes of tumor size and immune parameters were evaluated on the untreated and nordamnacanthal treated mice. RESULTS: Nordamnacanthal was found to possess cytotoxic effects on MDA-MB231, MCF-7 and 4T1 cells in vitro. Moreover, based on the cell cycle and Annexin V results, nordamnacanthal managed to induce cell death in both MDA-MB231 and MCF-7 cells. Additionally, no mortality, signs of toxicity and changes of serum liver profile were observed in nordamnacanthal treated mice in the subchronic toxicity study. Furthermore, 50 mg/kg body weight of nordamncanthal successfully delayed the progression of 4T1 tumors in Balb/C mice after 28 days of treatment. Treatment with nordamnacanthal was also able to increase tumor immunity as evidenced by the immunophenotyping of the spleen and YAC-1 cytotoxicity assays. CONCLUSION: Nordamnacanthal managed to inhibit the growth and induce cell death in MDA-MB231 and MCF-7 cell lines in vitro and cease the tumor progression of 4T1 cells in vivo. Overall, nordamnacanthal holds interesting anti-cancer properties that can be further explored.
[Mh] MeSH terms primary: Aldehydes/pharmacology
Anthraquinones/pharmacology
Antineoplastic Agents/pharmacology
Breast Neoplasms/metabolism
Immunologic Factors/pharmacology
Morinda/chemistry
Plant Extracts/pharmacology
[Mh] MeSH terms secundary: Aldehydes/chemistry
Aldehydes/toxicity
Animals
Anthraquinones/chemistry
Anthraquinones/toxicity
Antineoplastic Agents/chemistry
Antineoplastic Agents/toxicity
Apoptosis/drug effects
Cell Line, Tumor
Female
Humans
Immunologic Factors/chemistry
Immunologic Factors/toxicity
MCF-7 Cells
Male
Mice
Mice, Inbred BALB C
Plant Extracts/chemistry
Plant Extracts/toxicity
Toxicity Tests, Subchronic
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Aldehydes); 0 (Anthraquinones); 0 (Antineoplastic Agents); 0 (Immunologic Factors); 0 (Plant Extracts); 0 (nordamnacanthal)
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:180129
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-018-2102-3

  8 / 6898 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29331654
[Au] Autor:Xu Y; Mao X; Qin B; Peng Y; Zheng J
[Ad] Address:Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, PR China.
[Ti] Title:In vitro and in vivo metabolic activation of rhein and characterization of glutathione conjugates derived from rhein.
[So] Source:Chem Biol Interact;283:1-9, 2018 Mar 01.
[Is] ISSN:1872-7786
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:Rhein (RH), 4,5-dihydroxyanthrauinone-2-carboxylic acid, is found in rhubarb (Dahuang), a traditional herbal medicine. RH has reportedly demonstrated multiple pharmacologic properties. Previous studies have also shown that RH induced hepatotoxicity, but the mechanisms of the adverse effect remain unknown. The major objective of the present study was to study the metabolic pathways of RH in order to identify potential reactive metabolites. One mono-hydroxylation metabolite (M1) was detected in urine and bile of rats given RH. M1 was also observed in rat and human liver microsomal incubations after exposure to RH. A total of three (GSH) conjugates (M2, M3 and M5) were detected in bile of rats treated with RH. We concluded that M2-M3 were directly derived from parent compound RH through spontaneous reaction with GSH. M5 was derived from M1 by reaction with GSH, which required cytoslic GSTs. M5 was further metabolized to the corresponding NAC conjugate (mercapturic acid) and was excreted in urine. P450 2C9 was mainly involved in the oxidation of RH.
[Mh] MeSH terms primary: Anthraquinones/metabolism
Glutathione/chemistry
[Mh] MeSH terms secundary: Acetylcysteine/chemistry
Animals
Anthraquinones/chemistry
Anthraquinones/pharmacology
Anthraquinones/urine
Bile/chemistry
Bile/drug effects
Bile/metabolism
Chromatography, High Pressure Liquid
Cytochrome P-450 Enzyme System/genetics
Cytochrome P-450 Enzyme System/metabolism
Humans
Male
Microsomes, Liver/drug effects
Microsomes, Liver/metabolism
Rats
Rats, Sprague-Dawley
Recombinant Proteins/biosynthesis
Recombinant Proteins/genetics
Tandem Mass Spectrometry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anthraquinones); 0 (Recombinant Proteins); 9035-51-2 (Cytochrome P-450 Enzyme System); GAN16C9B8O (Glutathione); WYQ7N0BPYC (Acetylcysteine); YM64C2P6UX (rhein)
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:180115
[St] Status:MEDLINE

  9 / 6898 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 29180865
[Au] Autor:Zeng D; Zhang X; Wang X; Cao L; Zheng A; Du J; Li Y; Huang Q; Jiang X
[Ad] Address:Department of Prosthodontics, School of Medicine, Ninth People's Hospital affiliated to Shanghai Jiao Tong University, Shanghai, People's Republic of China.
[Ti] Title:Fabrication of large-pore mesoporous Ca-Si-based bioceramics for bone regeneration.
[So] Source:Int J Nanomedicine;12:8277-8287, 2017.
[Is] ISSN:1178-2013
[Cp] Country of publication:New Zealand
[La] Language:eng
[Ab] Abstract:Our previous study revealed that mesoporous Ca-Si-based materials exhibited excellent osteoconduction because dissolved ions could form a layer of hydroxycarbonate apatite on the surface of the materials. However, the biological mechanisms underlying bone regeneration were largely unknown. The main aim of this study was to evaluate the osteogenic ability of large-pore mesoporous Ca-Si-based bioceramics (LPMSCs) by alkaline phosphatase assay, real-time PCR analysis, von Kossa, and alizarin red assay. Compared with large-pore mesoporous silica (LPMS), LPMSCs had a better effect on the osteogenic differentiation of dental pulp cells. LPMSC-2 and LPMSC-3 with higher calcium possessed better osteogenic abilities than LPMSC-1, which may be related to the calcium-sensing receptor pathway. Furthermore, the loading capacity for recombinant human platelet-derived growth factor-BB was satisfactory in LPMSCs. In vivo, the areas of new bone formation in the calvarial defect repair were increased in the LPMSC-2 and LPMSC-3 groups compared with the LPMSC-1 and LPMS groups. We concluded that LPMSC-2 and LPMSC-3 possessed both excellent osteogenic abilities and satisfactory loading capacities, which may be attributed to their moderate Ca/Si molar ratio. Therefore, LPMSCs with moderate Ca/Si molar ratio might be potential alterative grafts for craniomaxillofacial bone regeneration.
[Mh] MeSH terms primary: Bone Regeneration/physiology
Calcium/chemistry
Materials Testing/methods
Silicon Dioxide/chemistry
[Mh] MeSH terms secundary: Alkaline Phosphatase/metabolism
Animals
Anthraquinones/analysis
Anthraquinones/metabolism
Biocompatible Materials/chemistry
Calcium Compounds/chemistry
Cell Differentiation
Ceramics/chemistry
Dental Pulp/cytology
Humans
Male
Naphthalenes/pharmacology
Nitrates/chemistry
Osteogenesis/drug effects
Platelet-Derived Growth Factor/genetics
Platelet-Derived Growth Factor/metabolism
Porosity
Rats, Sprague-Dawley
Real-Time Polymerase Chain Reaction
Skull/injuries
Skull/physiology
Tissue Scaffolds
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anthraquinones); 0 (Biocompatible Materials); 0 (Calcium Compounds); 0 (N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine); 0 (Naphthalenes); 0 (Nitrates); 0 (Platelet-Derived Growth Factor); 3F3AT0Q12H (Alizarin Red S); 7631-86-9 (Silicon Dioxide); EC 3.1.3.1 (Alkaline Phosphatase); NF52F38N1N (calcium nitrate); SY7Q814VUP (Calcium)
[Em] Entry month:1803
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[Js] Journal subset:IM
[Da] Date of entry for processing:171129
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S144528

  10 / 6898 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 29315599
[Au] Autor:Sun J; Wu Y; Dong S; Li X; Gao W
[Ad] Address:Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, PR China.
[Ti] Title:Influence of the drying method on the bioactive compounds and pharmacological activities of rhubarb.
[So] Source:J Sci Food Agric;, 2018 Jan 09.
[Is] ISSN:1097-0010
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Raw rhubarb samples that have been subjected to different drying procedures will have different therapeutic effects, possibly due to processing-induced variations in the chemical composition. In the present work, the fresh materials were processed by smoking, sun-drying, shade-drying and oven-drying at low, moderate and high temperatures. To facilitate the selection of a suitable drying method for rhubarb, the quality of rhubarb processed under various drying conditions was evaluated based on the simultaneous determination of multiple bioactive constituents in combination with bioactivity assays. RESULTS: The total concentrations of 12 compounds in smoked rhubarb were higher than the concentrations of the same components in raw rhubarb and rhubarb products processed using other drying techniques. Smoked rhubarb was found to substantially inhibit Na /K -ATPase and thrombin. In addition, higher content of anthraquinones led to higher Na /K -ATPase inhibitory activities, and higher gallic acid content increased the antithrombin capacity. CONCLUSION: The results confirmed that post-harvest fresh plant materials, especially roots, were still physiologically active organs that could undergo series of anti-dehydration mechanisms, including the production of related secondary metabolites during the early stages of dehydration. Therefore, the proper design of drying processes could enhance the quality of rhubarb as well as other similar medicinal plants. © 2018 Society of Chemical Industry.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180305
[Lr] Last revision date:180305
[St] Status:Publisher
[do] DOI:10.1002/jsfa.8871


page 1 of 690 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information