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[PMID]: 29427722
[Au] Autor:Palanikumar P; Daffni Benitta DJ; Lelin C; Thirumalaikumar E; Michaelbabu M; Citarasu T
[Ad] Address:Centre for Marine Science and Technology, Manonmaniam Sundaranar University, Rajakkamangalam 629 502 Tamilnadu, India.
[Ti] Title:Effect of Argemone mexicana active principles on inhibiting viral multiplication and stimulating immune system in Pacific white leg shrimp Litopenaeus vannamei against white spot syndrome virus.
[So] Source:Fish Shellfish Immunol;75:243-252, 2018 Feb 07.
[Is] ISSN:1095-9947
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Argemone mexicana called as Mexican prickly poppy is a species of poppy found in Mexico and now widely naturalized in many parts of the world with broad range of bioactivities including anthelmintic, cures lepsory, skin-diseases, inflammations and bilious fevers. Plant parts of A. mexicana were serially extracted with hexane, ethyl acetate, methanol and performed antiviral and immunostimulant screening against WSSV and Vibrio harveyi respectively. The control groups succumbed to death 100% within three days, whereas the mortality was significantly (P < 0.5) reduced to 17.43 and 7.11 in the ethyl acetate extracts of stem and root treated shrimp group respectively. The same trend was reflected in the immunostimulant screening also. Different diets were prepared by the concentrations of 100 (AD-1), 200 (AD-2), 300 (AD-3) and 400 (AD-4) mg kg using A. mexicana stem and root ethyl acetate extracts and fed to Pacific white leg shrimp Litopenaeus vannamei weighed about 9.0  0.5 g for 30 days. The control groups fed with the normal diets devoid of A. mexicana extracts. The antiviral screening results revealed that, the ethyl acetate extract of the stem and root were effectively suppressed the WSSV and it reflected in the lowest cumulative mortality of treated shrimps. After termination of feeding trials, group of shrimps from control and each experimental group were challenged with virulent WSSV by intramuscular (IM) injection and studied cumulative mortality, molecular diagnosis by quantitative real time PCR (qRT-PCR), biochemical, haematological and immunological parameters. Control group succumbed to 100% death within four days, whereas the survival was significantly (P < 0.001) increased to 30, 45, 75 and 79% in AD1, AD-2, AD-4 and AD-5 diets fed shrimp groups respectively. qRT PCR results with positive correlation analysis revealed that, the WSSV copies were gradually decreased when increasing the A. mexicana extracts in the diets. The highest concentrations (300 and 400 mg g ) of A. mexicana extracts in the diets helped to reduce the protein level significantly (P < 0.05) after WSSV challenge. The diets AD-3 and AD-4 also helped to decrease the coagulation time of maximum 64-67% from control groups and maintained the normal level of total haemocyte, oxyhaemocyanin level after WSSV challenge. The proPO level was significantly increased (Column: F = 35.93; P ≤ 0.001 and Row: F = 37.14; P ≤ 0.001) in the AD1-AD-4 diet fed groups from the control diet fed groups. The lowest intra-agar lysozyme activity of 1.63 mm found in control diet fed group and the activity were significantly (P < 0.05) increased to 4.86, 7.89, 9.12 and 10.45 mm of zone of inhibition respectively in AD1 to AD4 diet fed groups.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180226
[Lr] Last revision date:180226
[St] Status:Publisher

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[PMID]: 29232416
[Au] Autor:More NV; Kharat KR; Kharat AS
[Ad] Address:Department of Biotechnology, Dr. Babasaheb Ambedkar Marathwada University, Subcampus, Osmanabad 413501, Maharashtra, India.
[Ti] Title:Berberine from Argemone mexicana L exhibits a broadspectrum antibacterial activity.
[So] Source:Acta Biochim Pol;64(4):653-660, 2017.
[Is] ISSN:1734-154X
[Cp] Country of publication:Poland
[La] Language:eng
[Ab] Abstract:The Argemone mexicana L, commonly found on desolate land in the Marathwada region of Maharashtra state, India, has been used for treating oral cavity infections. We sought to investigate the antimicrobial potential of A. mexicana L. In this study, cold aqueous and methanolic extracts were prepared from the A. mexicana L leaves. These extracts were tested for their antibacterial activities against selected bacterial isolates. The antibacterial activity and MICs were tested using the agar well diffusion method and broth dilution method, respectively. The cold aqueous and methanolic extracts of A. mexicana L leaves inhibited growth of clinical isolates of Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa.The antibacterial potentiality of A. mexicana L extracts was compared with Streptomycin - the reference antibiotic used in this study. The active ingredient of antibacterial potentiality within the A. mexicana L extract was purified and characterized by TLC, HPLC and NMR analysis. Structural elucidation of Berberine and its bioactivity both, from the A. mexicana L and commercial preparation, is investigated.
[Mh] MeSH terms primary: Anti-Bacterial Agents/pharmacology
Argemone/chemistry
Berberine/pharmacology
Plant Extracts/chemistry
[Mh] MeSH terms secundary: Anti-Bacterial Agents/chemistry
Berberine/isolation & purification
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Escherichia coli/drug effects
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Plant Extracts/analysis
Plant Extracts/pharmacology
Plant Leaves/chemistry
Pseudomonas aeruginosa/drug effects
Staphylococcus aureus/drug effects
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Bacterial Agents); 0 (Plant Extracts); 0I8Y3P32UF (Berberine)
[Em] Entry month:1802
[Cu] Class update date: 180223
[Lr] Last revision date:180223
[Js] Journal subset:IM
[Da] Date of entry for processing:171213
[St] Status:MEDLINE
[do] DOI:10.18388/abp.2017_1621

  3 / 190 MEDLINE  
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[PMID]: 29125236
[Au] Autor:Lechner H; Soriano P; Poschner R; Hailes HC; Ward JM; Kroutil W
[Ad] Address:Institute of Chemistry, University of Graz, NAWI Graz, BioTechMed Graz, Heinrichstrae 28, 8010 Graz, Austria.
[Ti] Title:Library of norcoclaurine synthases and their immobilization for biocatalytic transformations.
[So] Source:Biotechnol J;, 2017 Nov 10.
[Is] ISSN:1860-7314
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Norcoclaurine synthases (NCS), catalyzing a Pictet-Spengler reaction in plants as one of the first enzymes in the biosynthetic benzylisoquinoline pathway, were investigated for biocatalytic transformations. The library of norcoclaurine synthases available was extended by two novel NCSs from Argemone mexicana (AmNCS1, AmNCS2) and one new NCS from Corydalis saxicola (CsNCS); furthermore, it was shown that the NCS from Papaver bracteatum (PbNCS) is a highly productive catalyst leading to the isoquinoline product with up to >99% e.e. Under certain conditions lyophilized whole E. coli cells containing the various overexpressed NCS turned out to be suitable catalysts. The reaction using dopamine as substrate bears several challenges such as the spontaneous non-stereoselective background reaction and side reactions. The PbNCS enzyme was successfully immobilized on various carriers whereby EziG3 proved to be the best suited for biotransformations. Dopamine showed limited stability in solution resulting in the coating of the catalyst over time, which could be solved by the addition of ascorbic acid (e.g. 1 mg/ml) as antioxidant.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171110
[Lr] Last revision date:171110
[St] Status:Publisher
[do] DOI:10.1002/biot.201700542

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[PMID]: 28894625
[Au] Autor:Magos-Guerrero GA; Santiago-Meja J; Carrasco OF
[Ad] Address:Department of Pharmacology, School of Medicine, Universidad Nacional Autnoma de Mxico, Mexico City 04510, Mexico.
[Ti] Title:Exploratory studies of some Mexican medicinal plants: Cardiovascular effects in rats with and without hypertension.
[So] Source:J Intercult Ethnopharmacol;6(3):274-279, 2017 Jul-Sep.
[Is] ISSN:2146-8397
[Cp] Country of publication:Turkey
[La] Language:eng
[Ab] Abstract:BACKGROUND: L., (L.) ., . and (Hook. & Grev.) Spring., have been used in Mexican traditional medicine to treat hypertension. The objective of this study was to further characterize the cardiovascular effects of the methanol extracts of such plants. METHODS: The medicinal plants were collected and taxonomically identified; the methanol extract of each explored plant were administrated to conscious and unconscious male Wistar rats with and without glucose-induced hypertension. The blood pressure (BP) and heart rate (HR) were evaluated before and after the extract administration. Vascular reactivity experiments were conducted in rat aortic rings obtained from rats with and without sugar-induced hypertension, a model widely used to study such effects with cardiovascular agents. RESULTS: After oral administration in normotensive conscious rats all tested extracts decreased the HR, such effect was only observed in hypertensive conscious rats after the administration of ; only and decreased the BP after oral administration. All extracts administrated by intravenous injection diminished the mean arterial pressure. Dose-response curves to cumulative concentrations of all the extracts promote vascular relaxation in precontracted aortas from rats with and without sugar-induced hypertension. CONCLUSIONS: The present study indicated that is worthy of further investigation as a potential phytotherapeutic agent for treating hypertension.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170914
[Lr] Last revision date:170914
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.5455/jice.20170706061922

  5 / 190 MEDLINE  
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[PMID]: 28875834
[Au] Autor:Nancy A; Praveena A
[Ad] Address:Department of Biochemistry, K.S. Rangasamy College of Arts and Science, Tiruchengode 637215, TamilNadu. India.
[Ti] Title:Argemone mexicana: A Boon to Medicinal and Pharmacological Approaches in Current Scenario.
[So] Source:Cardiovasc Hematol Agents Med Chem;, 2017 Aug 30.
[Is] ISSN:1875-6182
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Nature is God's gift to human beings. Natural products are a source of new chemical diversity and are the choice of today's world. Nature itself gives remedy to all our health problems. The sources of natural product are plants, animals and microorganisms. Among them plant and its products are more reliable for its renewability and therefore, considered as fortunate thing for human welfare. Our traditional system of medicine which has been followed by our ancestors has its own impact on human life. Due to the inadequate knowledge many plant derived products (drugs) has not yet been explored to the society. We are having many side effects and long term complications in synthetic drugs. Our aim is to mine the precious data about the plant Argemone mexicana. Now-a-days people prefer a drug which has no side effects. For that, the plant Argemone mexicana is a boon to the human being as it has a number of miraculous compounds to cure a various types of diseases. Single plant has a lot of uncountable benefits in drug discovery and which gives a base for new drug discovery. This plant is a weed, easily available and it does not require any special care which forms the base to develop a drug in socio economic form so that it could be made available to all people. This chapter provides an insight into various interesting pharmacological properties viz., Antidiabetic activity , Anti-Cancer activity, Anti-HIV activity, CNS related activities, Wound recovering action, Anti microbial activity, Antioxidant activity, Anti-inflammatory, analgesic, antipyretic activity, Hepatoprotective activity, Anti-fertility activity, Antiallergic activity, Nematicidal activity, Allelopathic effect, Antihelmintic activity, Larvicidal activity, Antifeedant action etc., which has been reviewed from different literatures in scientific journals. This present review would kindle many of the young minds to turn towards the nature i.e., plant based novel drug discovery with in-depth and extensive studies in all relevant aspects. Hence the paramount importance of this review about Argemone mexicana will be very much useful to the society.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170906
[Lr] Last revision date:170906
[St] Status:Publisher
[do] DOI:10.2174/1871525715666170830130155

  6 / 190 MEDLINE  
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[PMID]: 28708094
[Au] Autor:Siatka T; Adamcov M; Opletal L; Cahlkov L; Jun D; Hrabinov M; Kunes J; Chlebek J
[Ad] Address:Department of Pharmacognosy, Faculty of Pharmacy, Charles University, Akademika Heyrovskho 1203, 500 05 Hradec Krlov, Czech Republic. tomas.siatka@faf.cuni.cz.
[Ti] Title:Cholinesterase and Prolyl Oligopeptidase Inhibitory Activities of Alkaloids from Argemone platyceras (Papaveraceae).
[So] Source:Molecules;22(7), 2017 Jul 14.
[Is] ISSN:1420-3049
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Alzheimer's disease is an age-related, neurodegenerative disorder, characterized by cognitive impairment and restrictions in activities of daily living. This disease is the most common form of dementia with complex multifactorial pathological mechanisms. Many therapeutic approaches have been proposed. Among them, inhibition of acetylcholinesterase, butyrylcholinesterase, and prolyl oligopeptidase can be beneficial targets in the treatment of Alzheimer's disease. Roots, along with aerial parts of , were extracted with ethanol and fractionated on an alumina column using light petrol, chloroform and ethanol. Subsequently, repeated preparative thin-layer chromatography led to the isolation of (+)-laudanosine, protopine, (-)-argemonine, allocryptopine, (-)-platycerine, (-)-munitagine, and (-)-norargemonine belonging to pavine, protopine and benzyltetrahydroisoquinoline structural types. Chemical structures of the isolated alkaloids were elucidated by optical rotation, spectroscopic and spectrometric analysis (NMR, MS), and comparison with literature data. (+)-Laudanosine was isolated from for the first time. Isolated compounds were tested for human blood acetylcholinesterase, human plasma butyrylcholinesterase and recombinant prolyl oligopeptidase inhibitory activity. The alkaloids inhibited the enzymes in a dose-dependent manner. The most active compound (-)-munitagine, a pavine alkaloid, inhibited both acetylcholinesterase and prolyl oligopeptidase with IC values of 62.3 5.8 M and 277.0 31.3 M, respectively.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170714
[Lr] Last revision date:170714
[St] Status:In-Process

  7 / 190 MEDLINE  
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[PMID]: 28688319
[Au] Autor:Khamparia S; Jaspal D
[Ad] Address:Symbiosis International University (SIU), Lavale, Mulshi Taluka, Pune, Maharashtra 412115, India. Electronic address: shraddhagarg2285@gmail.com.
[Ti] Title:Study of decolorisation of binary dye mixture by response surface methodology.
[So] Source:J Environ Manage;201:316-326, 2017 Oct 01.
[Is] ISSN:1095-8630
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Decolorisation of a complex mixture of two different classes of textile dyes Direct Red 81 (DR81) and Rhodamine B (RHB), simulating one of the most important condition in real textile effluent was investigated onto deoiled Argemone Mexicana seeds (A.Mexicana). The adsorption behaviour of DR81 and RHB dyes was simultaneously analyzed in the mixture using derivative spectrophotometric method. Central composite design (CCD) was employed for designing the experiments for this complex binary mixture where significance of important parameters and possible interactions were analyzed by response surface methodology (RSM). Maximum adsorption of DR81 and RHB by A.Mexicana was obtained at 53C after 63.33min with 0.1g of adsorbent and 8נ10M DR81, 12נ10M RHB with composite desirability of 0.99. The predicted values for percentage removal of dyes from the mixture were in good agreement with the experimental values with R > 96% for both the dyes. CCD superimposed RSM confirmed that presence of different dyes in a solution created a competition for the adsorbent sites and hence interaction of dyes was one of the most important factor to be studied to simulate the real effluent. The adsorbent showed remarkable adsorption capacities for both the dyes in the mixture.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170728
[Lr] Last revision date:170728
[St] Status:In-Process

  8 / 190 MEDLINE  
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[PMID]: 28578091
[Au] Autor:Jasso Daz G; Hernndez GT; Zamilpa A; Becerril Prez CM; Ramrez Bribiesca JE; Hernndez Mendo O; Snchez Arroyo H; Gonzlez Cortazar M; Mendoza de Gives P
[Ad] Address:Colegio de Postgraduados, Campus Montecillo, Texcoco, Estado de Mxico, CP 56230, Mexico. Electronic address: gabydiaz_86@hotmail.com.
[Ti] Title:Invitro assessment of Argemone mexicana, Taraxacum officinale, Ruta chalepensis and Tagetes filifolia against Haemonchus contortus nematode eggs and infective (L ) larvae.
[So] Source:Microb Pathog;109:162-168, 2017 Aug.
[Is] ISSN:1096-1208
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Argemone mexicana, Taraxacum officinale, Ruta chalepensis and Tagetes filifolia are plants with deworming potential. The purpose of this study was to evaluate methanolic extracts of aerial parts of these plants against Haemonchus contortus eggs and infective larvae (L3) and identify compounds responsible for the anthelmintic activity. Invitro probes were performed to identify the anthelmintic activity of plant extracts: egg hatching inhibition (EHI) and larvae mortality. Open column Chromatography was used to bio-guided fractionation of the extract, which shows the best anthelmintic effect. The lethal concentration to inhibit 50% of H.contortus egg hatching or larvae mortality (LC ) was calculated using a Probit analysis. Bio-guided procedure led to the recognition of an active fraction (TF11) mainly composed by 1) quercetagitrin, 2) methyl chlorogenate and chlorogenic acid. Quercetagitrin (1) and methyl chlorogenate (2) did not show an important EHI activity (3-14%) (p<0.05); however, chlorogenic acid (3) showed 100% of EHI (LC 248g/mL) (p<0.05). Chlorogenic acid is responsible of the ovicidal activity and it seems that, this compound is reported for the first time with anthelmintic activity against a parasite of importance in sheep industry.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1706
[Cu] Class update date: 170708
[Lr] Last revision date:170708
[St] Status:In-Process

  9 / 190 MEDLINE  
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[PMID]: 28427461
[Au] Autor:Mohieldin EAM; Muddathir AM; Mitsunaga T
[Ad] Address:Faculty of Pharmacy, University of Science and Technology, Omdurman, Sudan.
[Ti] Title:Inhibitory activities of selected Sudanese medicinal plants on Porphyromonas gingivalis and matrix metalloproteinase-9 and isolation of bioactive compounds from Combretum hartmannianum (Schweinf) bark.
[So] Source:BMC Complement Altern Med;17(1):224, 2017 Apr 20.
[Is] ISSN:1472-6882
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Periodontal diseases are one of the major health problems and among the most important preventable global infectious diseases. Porphyromonas gingivalis is an anaerobic Gram-negative bacterium which has been strongly implicated in the etiology of periodontitis. Additionally, matrix metalloproteinases-9 (MMP-9) is an important factor contributing to periodontal tissue destruction by a variety of mechanisms. The purpose of this study was to evaluate the selected Sudanese medicinal plants against P. gingivalis bacteria and their inhibitory activities on MMP-9. METHODS: Sixty two methanolic and 50% ethanolic extracts from 24 plants species were tested for antibacterial activity against P. gingivalis using microplate dilution assay method to determine the minimum inhibitory concentration (MIC). The inhibitory activity of seven methanol extracts selected from the 62 extracts against MMP-9 was determined by Colorimetric Drug Discovery Kit. In search of bioactive lead compounds, Combretum hartmannianum bark which was found to be within the most active plant extracts was subjected to various chromatographic (medium pressure liquid chromatography, column chromatography on a Sephadex LH-20, preparative high performance liquid chromatography) and spectroscopic methods (liquid chromatography-mass spectrometry, Nuclear Magnetic Resonance (NMR)) to isolate and characterize flavogalonic acid dilactone and terchebulin as bioactive compounds. RESULTS: About 80% of the crude extracts provided a MIC value ≤4mg/ml against bacteria. The extracts which revealed the highest potency were: methanolic extracts of Terminalia laxiflora (wood; MIC =0.25mg/ml) followed by Acacia totrtilis (bark), Ambrosia maritima (aerial part), Argemone mexicana (seed), C. hartmannianum (bark), Terminalia brownii (wood) and 50% ethanolic extract of T. brownii (bark) with MIC values of 0.5mg/ml. T. laxiflora (wood) and C. hartmannianum (bark) which belong to combretaceae family showed an inhibitory activity over 50% at the concentration of 10g/ml against MMP-9. Additionally, MMP-9 was significantly inhibited by terchebulin with IC value of 6.7M. CONCLUSIONS: To the best of our knowledge, flavogalonic acid dilactone and terchebulin were isolated from C. hartmannianium bark for the first time in this study. Because of terchebulin and some crude extracts acting on P. gingivalis bacteria and MMP-9 enzyme that would make them promising natural preference for preventing and treating periodontal diseases.
[Mh] MeSH terms primary: Anti-Bacterial Agents/pharmacology
Combretum/chemistry
Matrix Metalloproteinase 9/metabolism
Periodontal Diseases
Plant Extracts/pharmacology
Plants, Medicinal
Porphyromonas gingivalis/drug effects
[Mh] MeSH terms secundary: Acacia
Ambrosia
Argemone
Hydrolyzable Tannins/isolation & purification
Hydrolyzable Tannins/pharmacology
Lactones/isolation & purification
Lactones/pharmacology
Medicine, African Traditional
Periodontal Diseases/drug therapy
Periodontal Diseases/microbiology
Plant Bark/chemistry
Plant Extracts/chemistry
Sudan
Terminalia
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Bacterial Agents); 0 (Hydrolyzable Tannins); 0 (Lactones); 0 (Plant Extracts); 0 (terchebulin); EC 3.4.24.35 (Matrix Metalloproteinase 9)
[Em] Entry month:1707
[Cu] Class update date: 170731
[Lr] Last revision date:170731
[Js] Journal subset:IM
[Da] Date of entry for processing:170422
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1735-y

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[PMID]: 27837372
[Au] Autor:Xool-Tamayo J; Serrano-Gamboa G; Monforte-Gonzlez M; Mirn-Lpez G; Vzquez-Flota F
[Ad] Address:Posgrado Interinstitucional en Ciencias Qumicas y Bioqumicas, Facultad de Qumica, Universidad Autnoma de Yucatn, Calle 43 No. 613 x, Calle 90, Col. Inalmbrica, 97069, Mrida, Yucatn, Mxico.
[Ti] Title:Development of newly sanguinarine biosynthetic capacity in in vitro rootless shoots of Argemone mexicana L. Mexican prickly poppy.
[So] Source:Biotechnol Lett;39(2):323-330, 2017 Feb.
[Is] ISSN:1573-6776
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To analyze berberine and sanguinarine biosynthetic capacities of both in vitro shoot and root cultures of Argemone mexicana and tissues from entire plants at different developmental stages. RESULTS: Berberine and sanguinarine were equally distributed in roots and aerial tissues of developing plantlet whereas, in juvenile plants, sanguinarine was only detected in roots. This alkaloid distribution was consistent with that of biosynthetic transcripts in juvenile plants. However, lower transcript abundance in plantlets leaves suggests that alkaloids were mainly formed in roots and then mobilized to this tissue. In vitro root cultures maintained similar alkaloid profiles to those from intact seedlings and plantlets. However, in addition to berberine, rootless shoot cultures accumulated high levels of sanguinarine and biosynthetic transcripts. CONCLUSION: In vitro shoot cultures of A. mexicana can synthesize sanguinarine in addition to berberine. This represent a convenient system for the production of both alkaloids.
[Mh] MeSH terms primary: Argemone/metabolism
Benzophenanthridines/metabolism
Isoquinolines/metabolism
Plant Shoots/metabolism
[Mh] MeSH terms secundary: Argemone/genetics
Berberine/metabolism
Plant Shoots/genetics
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Benzophenanthridines); 0 (Isoquinolines); 0I8Y3P32UF (Berberine); AV9VK043SS (sanguinarine)
[Em] Entry month:1703
[Cu] Class update date: 170308
[Lr] Last revision date:170308
[Js] Journal subset:IM
[Da] Date of entry for processing:161113
[St] Status:MEDLINE
[do] DOI:10.1007/s10529-016-2250-9


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