Database : MEDLINE Search on : Aspergillosis [Words] References found : 14097 [refine] Displaying: 1 .. 10   in format [Detailed]

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[PMID]: 23671611 [Au] Autor: Sekonyela R; Palmer JM; Bok JW; Jain S; Berthier E; Forseth R; Schroeder F; Keller NP [Ad] Address: Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America. [Ti] Title: RsmA Regulates Aspergillus fumigatus Gliotoxin Cluster Metabolites Including Cyclo(L-Phe-L-Ser), a Potential New Diagnostic Marker for Invasive Aspergillosis. [So] Source: PLoS One;8(5):e62591, 2013. [Is] ISSN: 1932-6203 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: Dimeric basic leucine zipper (bZIP) proteins are conserved transcriptional enhancers found in all eukaryotes. A recently reported and novel function for bZIPs is association of these proteins with secondary metabolite production in filamentous fungi. In particular a Yap-like bZIP termed RsmA (restorer of secondary metabolism A) was identified in Aspergillus nidulans that positively regulates the carcinogen sterigmatocystin. To assess for conserved function for RsmA, we examined a role of this protein in secondary metabolism in the pathogen A. fumigatus. RsmA was found to positively regulate gliotoxin where overexpression (OE) of rsmA led to 2-100 fold increases of twelve gli cluster metabolites in culture medium including the newly identified gli metabolite cyclo(L-Phe-L-Ser). Lungs from both wild type and OErsmA infected mice contained gliotoxin (2.3 fold higher in OErsmA treatment) as well as the gliotoxin precursor cyclo(L-Phe-L-Ser) (3.2 fold higher in OErsmA treatment). The data here presents a conserved role for RsmA in secondary metabolite cluster activation and suggests cyclo(L-Phe-L-Ser) may serve as an alternative marker for diagnosis of invasive aspergillosis. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1305 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1371/journal.pone.0062591

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[PMID]: 23486712 [Au] Autor: White PL; Parr C; Thornton C; Barnes RA [Ad] Address: Public Health Wales, Microbiology Cardiff, UHW, Cardiff, United Kingdom. [Ti] Title: Evaluation of real-time PCR, galactomannan enzyme-linked immunosorbent assay (ELISA), and a novel lateral-flow device for diagnosis of invasive aspergillosis. [So] Source: J Clin Microbiol;51(5):1510-6, 2013 May. [Is] ISSN: 1098-660X [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: Diagnosis of invasive aspergillosis (IA) remains challenging. With a relatively low incidence of disease, the use of expensive empirical antifungal therapy exposes many patients to unnecessary toxicity. Diagnosis places emphasis on specific but temporal radiological evidence. Circulating biomarker diagnosis has shown potential, but assays show variable performance, take several hours to perform, and require a degree of technical ability. A novel and simple lateral-flow device (LFD) using monoclonal antibody JF5, which targets an extracellular glycoprotein, has been developed and potentially removes any technical requirements, reducing processing time considerably. In this study, we evaluate the performance of this LFD compared to real-time PCR (targeting the 28S rRNA gene) and galactomannan (GM) detection when testing serum from a European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group, National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG)-defined hematological population. In a proven/probable-IA population versus a no-IA population, the LFD performance was comparable to that of both PCR and galactomannan enzyme immunoassay. Specificity (98.0%) was similar to that of PCR (96.6%) and slightly superior to that of GM (91.5%). Sensitivity (81.8%) was inferior to that of PCR (95.5%) but better than that of GM (77.3%). In combination with PCR, it provided both 100% sensitivity and 100% specificity. The LFD permits rapid testing of easily obtainable specimens, to be used as an adjunct test, before confirmation by other investigations. Its simplicity provides centers without specialist diagnostics with a test with clinical performance superior to that of classical microbiological approaches and results that can be used to direct antifungal management. In summary, microbiological diagnosis of IA is difficult and options are limited, with variable performance. An LFD assay targeting a novel specific biomarker has been developed, one which is methodologically simple and provides good clinical performance, particularly if combined with PCR. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1304 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1128/JCM.03189-12

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[PMID]: 23467602 [Au] Autor: de Heer K; van der Schee MP; Zwinderman K; van den Berk IA; Visser CE; van Oers R; Sterk PJ [Ad] Address: Departments of Hematology. [Ti] Title: Electronic Nose Technology for Detection of Invasive Pulmonary Aspergillosis in Prolonged Chemotherapy-Induced Neutropenia: a Proof-of-Principle Study. [So] Source: J Clin Microbiol;51(5):1490-5, 2013 May. [Is] ISSN: 1098-660X [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: Although the high mortality rate of pulmonary invasive aspergillosis (IA) in patients with prolonged chemotherapy-induced neutropenia (PCIN) can be reduced by timely diagnosis, a diagnostic test that reliably detects IA at an early stage is lacking. We hypothesized that an electronic nose (eNose) could fulfill this need. An eNose can discriminate various lung diseases through the analysis of exhaled volatile organic compounds (VOCs). An eNose is cheap and noninvasive and yields results within minutes. In a single-center prospective cohort study, we included patients who were treated with chemotherapy expected to result in PCIN. Based on standardized indications, a full diagnostic workup was performed to confirm invasive aspergillosis or to rule it out. Patients with no aspergillosis were considered controls, and patients with probable or proven aspergillosis were considered index cases. Exhaled breath was examined with a Cyranose 320 (Smith Detections, Pasadena, CA). The resulting data were analyzed using principal component reduction. The primary endpoint was cross-validated diagnostic accuracy, defined as the percentage of patients correctly classified using the leave-one-out method. Accuracy was validated by 100,000 random classifications. We included 46 subjects who underwent 16 diagnostic workups, resulting in 6 cases and 5 controls. The cross-validated accuracy of the eNose in diagnosing IA was 90.9% (P = 0.022; sensitivity, 100%; specificity, 83.3%). Receiver operating characteristic analysis showed an area under the curve of 0.93. These preliminary data indicate that PCIN patients with IA have a distinct exhaled VOC profile that can be detected with eNose technology. The diagnostic accuracy of the eNose for invasive aspergillosis warrants validation. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1304 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1128/JCM.02838-12

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[PMID]: 23426930 [Au] Autor: Springer J; Morton CO; Perry M; Heinz WJ; Paholcsek M; Alzheimer M; Rogers TR; Barnes RA; Einsele H; Loeffler J; White PL [Ad] Address: University of Wuerzburg Medical Centre, Department for Internal Medicine II, Wuerzburg, Germany. [Ti] Title: Multicenter comparison of serum and whole-blood specimens for detection of Aspergillus DNA in high-risk hematological patients. [So] Source: J Clin Microbiol;51(5):1445-50, 2013 May. [Is] ISSN: 1098-660X [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: Samples from patients at high risk for invasive aspergillosis (IA) were prospectively collected and analyzed for the presence of molecular markers of fungal infection. Serum specimens were screened for galactomannan and Aspergillus DNA, and whole-blood specimens were screened only for Aspergillus DNA. Fungal infections were categorized according to the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group, National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) criteria. Forty-seven cases (proven and probable IA) and 31 controls (no evidence of IA) were selected retrospectively for this case-control study, comprising 803 samples, in order to determine the performance of whole-blood PCR, serum PCR, and serum galactomannan testing. Although no single assay was able to detect every case of IA, a combination of different assays provided the best performance. There was no significant difference between the use of whole-blood and serum specimens for PCR-based diagnosis of IA, but there was a trend for whole blood to be more sensitive (85% versus 79%) and to yield an earlier positive result (36 days versus 15 days) than for serum. However, DNA extraction from serum specimens is easier and faster than that from whole-blood specimens, and it allows the same specimen to be used for both galactomannan and PCR assays. In conclusion, the appropriate sample type for DNA extraction should be determined by the local requirements and the technical platforms available at each individual center. A combination of biomarker tests offered the best diagnostic utility for detecting IA. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1304 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1128/JCM.03322-12

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[PMID]: 23439304 [Au] Autor: Nguyen NL; Chen K; McAleer J; Kolls JK [Ad] Address: Department of Genetics, Louisiana State University Health Sciences Center (LSUHSC), New Orleans, Louisiana, USA. [Ti] Title: Vitamin D Regulation of OX40 Ligand in Immune Responses to Aspergillus fumigatus. [So] Source: Infect Immun;81(5):1510-9, 2013 May. [Is] ISSN: 1098-5522 [Cp] Country of publication: United States [La] Language: eng [Ab] Abstract: OX40 ligand (OX40L) is a costimulatory molecule involved in Th2 allergic responses. It has been shown that vitamin D deficiency is associated with increased OX40L expression in peripheral CD11c(+) cells and controls Th2 responses to Aspergillus fumigatus in vitro in cystic fibrosis (CF) patients with allergic bronchopulmonary aspergillosis (ABPA). To investigate if vitamin D deficiency regulated OX40L and Th2 responses in vivo, we examined the effect of nutritional vitamin D deficiency on costimulatory molecules in CD11c(+) cells and A. fumigatus-induced Th2 responses. Vitamin D-deficient mice showed increased expression of OX40L on lung CD11c(+) cells, and OX40L was critical for enhanced Th2 responses to A. fumigatus in vivo. In in vitro assays, vitamin D treatment led to vitamin D receptor (VDR) binding in the promoter region of OX40L and significantly decreased the promoter activity of the OX40L promoter. In addition, vitamin D altered NF-κB p50 binding in the OX40L promoter that may be responsible for repression of OX40L expression. These data show that vitamin D can act directly on OX40L, which impacts Th2 responses and supports the therapeutic use of vitamin D in diseases regulated by OX40L. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1304 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1128/IAI.01345-12

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[PMID]: 23540090 [Au] Autor: Singh UP; Aneja P; Aditi; Patel K [Ad] Address: Department of TB and Chest Diseases, Government Medical College, Patiala, Punjab. singhurvinderpal@hotmail.com [Ti] Title: Co-existence of HIV, active tuberculosis and aspergilloma in a single individual--a case report. [So] Source: Indian J Tuberc;60(1):55-8, 2013 Jan. [Is] ISSN: 0019-5707 [Cp] Country of publication: India [La] Language: eng [Ab] Abstract: Tuberculosis (TB) is a disease as old as mankind, whereas in India the first case of Human Immunodeficiency Virus (HIV) was reported in 1986. HIV and TB are so closely connected that their relationship is often described as a co-epidemic. Aspergilloma (Fungal Ball, Mycetoma) represents a saprophytic growth of aspergillus that colonizes in the preformed cavities commonly due to pulmonary tuberculosis (PTB). We report a case of HIV, active pulmonary tuberculosis and aspergilloma occurring in the same patient. Despite our best efforts, we could not lay our hands on any similar case in the medical literature. [Mh] MeSH terms primary: HIV Infections/complications HIV/immunology Pulmonary Aspergillosis/complications Tuberculosis, Pulmonary/complications [Mh] MeSH terms secundary: Aspergillus/isolation & purification Bronchoalveolar Lavage Fluid/microbiology Bronchoscopy Diagnosis, Differential HIV Antibodies/analysis HIV Infections/diagnosis Humans Male Middle Aged Mycobacterium tuberculosis/isolation & purification Pulmonary Aspergillosis/diagnosis Radiography, Thoracic Tomography, X-Ray Computed Tuberculosis, Pulmonary/diagnosis [Pt] Publication type: CASE REPORTS; JOURNAL ARTICLE [Nm] Name of substance: 0 (HIV Antibodies) [Em] Entry month: 1305 [Js] Journal subset: IM [Da] Date of entry for processing: 130401 [St] Status: MEDLINE

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[PMID]: 23510521 [Au] Autor: Herbrecht R; Sabou M; Ledoux MP [Ad] Address: Département d'oncologie et d'hématologie, Hôpital de Hautepierre, Hôpitaux universitaires de Strasbourg, Strasbourg, France. raoul.herbrecht@chru-strasbourg.fr [Ti] Title: Aspects cliniques et radiologiques des mucormycoses. [Clinical and radiological aspects of mucormycosis]. [So] Source: Med Sci (Paris);29 Spec No 1:19-24, 2013 Mar. [Is] ISSN: 0767-0974 [Cp] Country of publication: France [La] Language: fre [Ab] Abstract: Mucormycosis is an infection caused by filamentous fungi of the Mucorales order. The predisposing factors are mostly diabetic ketoacidosis and severe immunosuppressive conditions such as prolonged neutropenia, steroid or T-cell suppressor therapy, solid organ transplantation or allogeneic hematopoietic stem cell transplantation. Mucormycosis can also occur in immunocompetent patients, especially after trauma, burns or direct inoculation of the fungi (e.g. intravenous drug abuse). The most frequently targeted primary sites of infection are sinuses with a rapid spread to the adjacent tissues including the brain, the lower respiratory tract, the digestive tract and the skin. Mucorales are able to invade the vessels causing hematogenous dissemination, vascular thrombosis and, ultimately, necrosis of the lesions. Clinical and radiological aspects are similar to those observed in other invasive filamentous fungi infections such as invasive aspergillosis, fusariosis or scedosporiosis. CT-scan or MRI are mandatory to assess the extension of the lesions. The diagnosis remains difficult and is often delayed resulting in a poor outcome. [Pt] Publication type: ENGLISH ABSTRACT; JOURNAL ARTICLE [Em] Entry month: 1303 [Js] Journal subset: IM [St] Status: In-Process [do] DOI: 10.1051/medsci/201329s105

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[PMID]: 22864935 [Au] Autor: Karaman I; Karaman A; Boduroglu EC; Erdogan D; Tanir G [Ad] Address: Department of Pediatric Surgery, Dr. Sami Ulus Children's Hospital, Babür Cad., No: 44, Altindag, 06080, Ankara, Turkey, ibrahimkaraman@hotmail.com. [Ti] Title: Invasive Aspergillus infection localized to the gastric wall: report of a case. [So] Source: Surg Today;43(6):682-4, 2013 Jun. [Is] ISSN: 1436-2813 [Cp] Country of publication: Japan [La] Language: eng [Ab] Abstract: Invasive aspergillosis is most commonly seen in patients with immune disorders and usually in the lung. Local invasive aspergillosis of the gastrointestinal system is quite rare. A 13-year-old female without immune deficiency presented with acute abdomen due to full-thickness necrosis of the gastric fundus. The necrotic gastric wall was excised and the stomach repaired. The pathology revealed a gastric ulcer with invading Aspergillus hyphae and spores. Aspergillosis is an opportunistic infection and its spores cannot survive in the normal gastric mucosa. The Aspergillus spores in this case probably grew on a background of gastric ulcer and caused wall necrosis and that the surgical treatment possibly provided a cure because it remained localized to the gastric wall. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1305 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.1007/s00595-012-0255-0

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[PMID]: 23666221 [Au] Autor: Yamada A; Moritake H; Sawa D; Shimonodan H; Kojima H; Kamimura S; Nunoi H [Ad] Address: Division of Pediatrics, Department of Reproductive and Developmental Medicine, Faculty of Medicine, University of Miyazaki. [Ti] Title: Refractory acute myeloid leukemia developed malignancy-associated hemophagocytic lymphohistiocytosis during treatment of invasive fungal infection. [So] Source: Rinsho Ketsueki;54(4):383-7, 2013 Apr. [Is] ISSN: 0485-1439 [Cp] Country of publication: Japan [La] Language: eng [Ab] Abstract: We here report a 2-year-old female with relapsed acute myeloid leukemia (AML) with MLL gene rearrangement in the bone marrow and central nervous system. The 3'-RACE (Rapid Amplification of cDNA Ends) method identified the MLLT10 gene as a fusion partner of the MLL gene. The patient was complicated with hemophagocytic lymphohistiocytosis (HLH) and invasive aspergillosis (IPA) after re-induction treatment with FLAG-IDA following etoposide, cytarabine, and mitoxantrone. Although treatment with systemic anti-fungal drugs was effective for IPA, HLH did not improve. We considered tumor-associated HLH to be initiated from leukemic stem cells (LSCs) in the bone marrow niche because reverse transcription-polymerase chain reaction (RT-PCR) analysis of a bone marrow biopsy sample was positive for MLL-MLLT10. Gemtuzumab ozogamicin and sorafenib had no major effect on acquiring complete remission, and the patient died of progressive AML with an exacerbation of HLH and aspergillosis. LSCs are known to be resistant to conventional chemotherapy due to their quiescence in the cell cycle. Novel therapeutic concepts are important to eradicate LSCs in order to cure AML patients. [Pt] Publication type: JOURNAL ARTICLE [Em] Entry month: 1305 [Js] Journal subset: IM [St] Status: In-Data-Review

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[PMID]: 23660100 [Au] Autor: Xu SC; Dong XN; Baihetinisha T; Deng LJ; Guo XH; Sang XH; Qiu LH; Ren BX [Ad] Address: Department of Respiratory Intensive Care Unit, the First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang, China. Corresponding author: Xu Si-cheng, Email: xu_sicheng@yahoo.com.cn. [Ti] Title: [The initial CT findings in patients suffering from invasive pulmonary aspergillosis]. [So] Source: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue;25(4):229-32, 2013 Apr. [Is] ISSN: 2095-4352 [Cp] Country of publication: China [La] Language: chi [Ab] Abstract: OBJECTIVE: To approach the initial CT findings of invasive pulmonary aspergillosis (IPA) in patients with immunosuppression. METHODS: All consecutive adult patients who met the diagnostic criteria of the 2008 European Organization for Research and Treatment of Cancer/ Mycoses Study Group (EORTC/MSG) for proven or probable IPA were included as of January 2005 to June 2011. The patients were divided into two groups according to patients with or without hematological malignancy. The initial CT findings in our study were retrospectively reviewed by two thoracic radiologists, while patients' demographics and clinical outcomes were blinded. The pattern and number of abnormalities were recorded. RESULTS: A total of 65 IPA patients were eligible, with 34 hematological malignancy patients and 31 non-hematological patients. Among all IPA patients, the pattern of ground-glass opacity and consolidation or mass formation was most commonly seen (56.9%), followed by macronodules (46.2%); halo sign (32.3%) was relatively uncommon. Ground-glass opacity and consolidation or mass formation were more commonly identified in non-hematological patients than in hematological malignancy patients (54.8%, 45.2% vs. 8.8%, both P<0.05), but macronodules, infarct-shaped macronodules and halo signs were less frequently identified in the non-hematological group (16.1%, 3.2%, 12.9%, respectively) than in the hematological malignancy group (73.5%, 23.5% and 50.0%, respectively, P<0.05 or P<0.01). The airway-invasive form of IPA was more frequently seen in non-hematological patients (67.8%), whereas the angioinvasive form was more common in hematological malignancy patients (64.7%, P<0.01). CONCLUSION: Our data indicate that CT findings of IPA in non-hematological patients more commonly present as the airway-invasive form, manifesting ground-glass opacity and consolidation or mass formation, whereas in patients with hematological malignancy it more likely shows evidence of the angioinvasive form with macronodules and halo signs. [Pt] Publication type: ENGLISH ABSTRACT; JOURNAL ARTICLE [Em] Entry month: 1305 [Js] Journal subset: IM [St] Status: In-Data-Review [do] DOI: 10.3760/cma.j.issn.2095-4352.2013.04.012

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