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[PMID]: 25839116
[Au] Autor:Karadeniz A; Alexie G; Greten HJ; Andersch K; Efferth T
[Ad] Address:Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany; Mehmet Akif Ersoy University, Biology Department, Burdur, Turkey.
[Ti] Title:Cytotoxicity of medicinal plants of the West-Canadian Gwich׳in Native Americans towards sensitive and multidrug-resistant cancer cells.
[So] Source:J Ethnopharmacol;168:191-200, 2015 Jun 20.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: Traditional medicine of the Native Americans has a long tradition of medicinal plants, which also influenced modern oncology. For instance, podophyllotoxin the active ingredient of Podophyllum peltatum L. (Berberidaceae) used by Native Americans to treat warts led to the development of etoposide and teniposide. In the present investigation, we studied 10 medicinal plants used by the Gwich׳in First Nation of West-Canada, which have been used against diverse diseases including cancer. MATERIAL AND METHODS: Sensitive and multidrug-resistant (MDR) tumor cell lines expressing various ATP-binding cassette (ABC) transporters (P-glycoprotein/ABCB1/MDR1, MRP1/ABCC1, or BCRP/ABCG2) have been used. Cytotoxicity was determined by the resazurin assay. RESULTS: Arctium minus Bernh. (Asteraceae). Lysichiton americanus Hultén & St. John (Araceae), and Maianthemum dilatatum (Alph.Wood) A.Nelson & J.F.Macbr.(Asparagaceae) were cytotoxic with IC50 values ranging from 2.40 to 86.35 µg/mL. The MDR cell lines did not exert cross-resistance to these extracts. CONCLUSION: As these medicinal plants of the West-Canadian Gwich׳in First Nation were not involved in classical drug resistance mechanisms and might therefore be valuable to bypass anticancer drug resistance in refractory tumors.
[Mh] MeSH terms primary: ATP-Binding Cassette Transporters/genetics
Antineoplastic Agents/pharmacology
Araceae
Arctium
Liliaceae
Plant Extracts/pharmacology
Plants, Medicinal
[Mh] MeSH terms secundary: Canada
Cell Line, Tumor
Cell Survival/drug effects
Drug Resistance, Multiple/drug effects
Drug Resistance, Neoplasm/drug effects
Humans
Indians, North American
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (ATP-Binding Cassette Transporters); 0 (Antineoplastic Agents); 0 (Plant Extracts)
[Em] Entry month:1603
[Cu] Class update date: 171213
[Lr] Last revision date:171213
[Js] Journal subset:IM
[Da] Date of entry for processing:150404
[St] Status:MEDLINE

  2 / 236 MEDLINE  
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[PMID]: 29157003
[Au] Autor:Su XD; Li W; Ma JY; Kim YH
[Ad] Address:a College of Pharmacy , Chungnam National University , Daejeon , Republic of Korea.
[Ti] Title:Chemical constituents from Epimedium koreanum Nakai and their chemotaxonomic significance.
[So] Source:Nat Prod Res;:1-5, 2017 Nov 21.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:In this study, 21 compounds were isolated from the aerial parts of Epimedium koreanum Nakai, including 6 phenols (1-5 and 10), 4 lignans (6-9) and 11 flavonoids (11-21). The chemical structures of those isolates were established after extensive one-and two-dimensional nuclear magnetic resonance and mass spectroscopy analyses. This is the first report of compounds 2, 3, 4 and 9 in E. koreanum and of compounds 5 and 7 in the family Berberidaceae. The chemotaxonomic significance of the isolated compounds is discussed.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171121
[Lr] Last revision date:171121
[St] Status:Publisher
[do] DOI:10.1080/14786419.2017.1405412

  3 / 236 MEDLINE  
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[PMID]: 29029041
[Au] Autor:Williams SC; Linske MA; Ward JS
[Ad] Address:Department of Forestry and Horticulture, The Connecticut Agricultural Experiment Station, PO Box 1106, New Haven, CT 06504.
[Ti] Title:Long-Term Effects of Berberis thunbergii (Ranunculales: Berberidaceae) Management on Ixodes scapularis (Acari: Ixodidae) Abundance and Borrelia burgdorferi (Spirochaetales: Spirochaetaceae) Prevalence in Connecticut, USA.
[So] Source:Environ Entomol;, 2017 Sep 26.
[Is] ISSN:1938-2936
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Japanese barberry (Berberis thunbergii de Candolle; Ranunculales: Berberidaceae) is an exotic invasive shrub that escaped cultivation in the United States and is now permanently established in many eastern and midwestern states. This study examined the long-term impacts of Japanese barberry management on blacklegged tick (Ixodes scapularis Say; Acari: Ixodidae) abundances and associated prevalence of Borrelia burgdorferi (Johnson, Schmid, Hyde, Steigerwalt, and Brenner; Spirochaetales: Spirochaetaceae), the etiologic agent of Lyme disease. At six locations across Connecticut, adult I. scapularis were sampled for up to 10 yr. At each location, we sampled an area where barberry infestations were unmanipulated, adjacent areas where barberry was virtually nonexistent, and areas where barberry was managed utilizing a variety of techniques. Barberry management reduced B. burgdorferi-infected adult I. scapularis (BBIAIS) abundances (191/ha ± 64 SE) over 6 yr to statistically indifferent from that of no barberry areas (140/ha ± 47 SE; P = 0.080) and significantly less than intact barberry stands (458/ha ± 80 SE; P = 0.026). Over 9 yr, BBIAIS abundances in managed barberry remained lower than intact barberry stands (P = 0.037), but increased to be significantly greater than no barberry areas (P = 0.007) as cover increased over time. Longer-term data further document that Japanese barberry infestations are favorable habitat for I. scapularis. Control of Japanese barberry and other invasives should be at least on a 5-yr rotation to maintain low levels of invasive cover and eliminate humidity refugia to expose juvenile I. scapularis to more hostile environmental conditions in the interest of public health.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171013
[Lr] Last revision date:171013
[St] Status:Publisher
[do] DOI:10.1093/ee/nvx146

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[PMID]: 28901898
[Au] Autor:Zhang L; Li Q; Chen C; Li X; Li M; Hu J; Shen X
[Ad] Address:State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Sciences, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
[Ti] Title:Propioniciclava sinopodophylli sp. nov., isolated from leaves of Sinopodophyllum hexandrum (Royle) Ying.
[So] Source:Int J Syst Evol Microbiol;67(10):4111-4115, 2017 Oct.
[Is] ISSN:1466-5034
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A Gram-reaction-positive, facultatively anaerobic, rod-shaped and non-motile bacterial strain, designated TEYR-7 , was isolated from the leaves of Sinopodophyllum hexandrum collected from the Qinling Mountains in Shaanxi Province, northwest China. Growth of strain TEYR-7 occurred at 15-37 °C (optimum, 28-30 °C), at pH 6.0-9.0 (optimum, pH 7.0) and in the presence of 0-3 % (w/v) NaCl (optimum, 0-1 %). Propionate and acetate were produced from glucose fermentation. Phylogenetic analyses based on 16S rRNA gene sequences showed that strain TEYR-7 was a member of the phylum Actinobacteria, exhibiting the highest sequence similarity to Propioniciclava tarda DSM 22130 (94.3 %). The only respiratory quinone detected in strain TEYR-7 was menaquinone MK-9(H4) and the major cellular fatty acids (>10 %) were anteiso-C15 : 0 and C16 : 0. The polar lipid profile consisted of phosphatidylglycerol, diphosphatidylglycerol, two unidentified glycolipids, an unidentified phospholipid and three unidentified lipids. The genomic DNA G+C content was 71.2 mol%. meso-Diaminopimelic acid was detected in the peptidoglycan. On the basis of data from the present polyphasic taxonomic study, strain TEYR-7 is considered to represent a novel species of the genus Propioniciclava, for which the name Propioniciclava sinopodophylli sp. nov. is proposed. The type strain is TEYR-7 (=CCTCC AB 2015257 =KCTC 33808 ).
[Mh] MeSH terms primary: Berberidaceae/microbiology
Phylogeny
Plant Leaves/microbiology
Propionibacteriaceae/classification
[Mh] MeSH terms secundary: Bacterial Typing Techniques
Base Composition
Cell Wall/chemistry
China
DNA, Bacterial/genetics
Diaminopimelic Acid/chemistry
Fatty Acids/chemistry
Glycolipids/chemistry
Nucleic Acid Hybridization
Peptidoglycan/chemistry
Phospholipids/chemistry
Propionibacteriaceae/genetics
Propionibacteriaceae/isolation & purification
RNA, Ribosomal, 16S/genetics
Sequence Analysis, DNA
Vitamin K 2/analogs & derivatives
Vitamin K 2/chemistry
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Glycolipids); 0 (Peptidoglycan); 0 (Phospholipids); 0 (RNA, Ribosomal, 16S); 11032-49-8 (Vitamin K 2); 523-39-7 (menaquinone 9); 583-93-7 (Diaminopimelic Acid)
[Em] Entry month:1711
[Cu] Class update date: 171103
[Lr] Last revision date:171103
[Js] Journal subset:IM
[Da] Date of entry for processing:170914
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.002265

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[PMID]: 28884079
[Au] Autor:Ardalani H; Avan A; Ghayour-Mobarhan M
[Ad] Address:Department of Horticultural Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
[Ti] Title:Podophyllotoxin: a novel potential natural anticancer agent.
[So] Source:Avicenna J Phytomed;7(4):285-294, 2017 Jul-Aug.
[Is] ISSN:2228-7930
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:OBJECTIVE: The aim of the present review is to give an overview about the role, biosynthesis, and characteristics of Podophyllotoxin (PTOX) as a potential antitumor agent with particular emphasis on key biosynthesis processes, function of related enzymes and characterization of genes encoding the enzymes. MATERIALS AND METHODS: Google scholar, PubMed and Scopus were searched for literatures which have studied identification, characterization, fermentation and therapeutic effects of PTOX and published in English language until end of 2016. RESULTS: PTOX is an important plant-derived natural product, has derivatives such as etoposide and teniposide, which have been used as therapies for cancers and venereal wart. PTOX structure is closely related to the aryltetralin lactone lignans that have antineoplastic and antiviral activities. Wall. (syn. ) and L. (Berberidaceae) are the major sources of PTOX. It has been shown that ferulic acid and methylenedioxy substituted cinnamic acid are the enzymes involved in PTOX synthesis. PTOX prevents cell growth via polymerization of tubulin, leading to cell cycle arrest and suppression of the formation of the mitotic-spindles microtubules. CONCLUSION: Several investigations have been performed in biosynthesis of PTOX such as cultivation of these plants, though they were unsuccessful. Thus, it is important to find alternative sources to satisfy the pharmaceutical demand for PTOX. Moreover, further preclinical studies are warranted to explore the molecular mechanisms of these agents in treatment of cancer and their possible potential to overcome chemoresistance of tumor cells.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1709
[Cu] Class update date: 170910
[Lr] Last revision date:170910
[St] Status:PubMed-not-MEDLINE

  6 / 236 MEDLINE  
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[PMID]: 28781550
[Au] Autor:Liu S; Liu L; Huang X; Zhu Y; Xu Y
[Ad] Address:College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004 P. R. China.
[Ti] Title:A taxonomic revision of three Chinese spurless species of genus L. (Berberidaceae).
[So] Source:PhytoKeys;(78):23-36, 2017.
[Is] ISSN:1314-2011
[Cp] Country of publication:Bulgaria
[La] Language:eng
[Ab] Abstract:Due to some common or similar features (e.g., small leaf, spurless, yellow flower), three Chinese species of the genus (Berberidaceae), , , and , are controversial based on morphological characteristics. In the present study, the descriptions of morphological characteristics for the three species were revised based on extensive studies and observations both in field and in herbaria. In general, has long creeping rhizomes 1-3 mm in diameter, two alternate or opposite trifoliolate leaves, 7-14 flowers, and petals obovate and apex subacute. has short or long-creeping rhizomes 1-3 mm in diameter, one trifoliolate leaf, 2-6 flowers, and petals oblong and apex rounded. has compact rhizomes 4-6 mm in diameter, two alternate or opposite trifoliolate leaves, 15-43 flowers, and petals obovate and apex rounded. Through comparison, we found that despite the close affinity of these three species, they can be distinguished by rhizome differences, stem-leaves, the morphology of flower (e.g., petals), and the number of per inflorenscence.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170808
[Lr] Last revision date:170808
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.3897/phytokeys.78.11640

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[PMID]: 28720131
[Au] Autor:Alamgeer; Uttra AM; Hasan UH
[Ad] Address:Laboratory of Cardiovascular Research and Integrative Pharmacology, Department of Pharmacology, Faculty of Pharmacy, University Of Sargodha, Sargodha, Pakistan. alam_yuchi@yahoo.com.
[Ti] Title:Anti-arthritic activity of aqueous-methanolic extract and various fractions of Berberis orthobotrys Bien ex Aitch.
[So] Source:BMC Complement Altern Med;17(1):371, 2017 Jul 18.
[Is] ISSN:1472-6882
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The roots and stem bark of Berberis orthobotrys (Berberidaceae) have long been used traditionally to treat joint pain. Though, it has not been pharmacologically assessed for rheumatoid arthritis. The current study explores anti-arthritic activity and phytochemical analysis of aqueous-methanolic extract (30:70) and fractions (ethyl acetate, n-butanol, and aqueous) of Berberis orthobotrys roots. METHODS: Anti-arthritic potential was evaluated in vitro using protein denaturation (bovine serum albumin and egg albumin) and membrane stabilization methods at 12.5-800 µg/ml concentration and in vivo via turpentine oil, formaldehyde and Complete Freund Adjuvant (CFA) models at 50, 100 and 150 mg/kg doses. Also, in vitro antioxidant ability was appraised by reducing power assay. Moreover, total flavonoid content, Fourier transform infrared spectroscopy and High performance liquid chromatography of n-butanol fraction were performed. RESULTS: The results revealed concentration dependent inhibition of albumin denaturation and notable RBC membrane stabilization, with maximum results obtained at 800 µg/ml. Similarly, plant exhibited dose dependent anti-arthritic effect in turpentine oil and formaldehyde models, with maximum activity observed at 150 mg/kg. The results of CFA model depicted better protection against arthritic lesions and body weight alterations. Also, B.orthobotrys remarkably ameliorated altered hematological parameters, rheumatoid factor and positively modified radiographic and histopathological changes. Additionally, plant exhibited remarkable anti-oxidant activity. Moreover, phytochemical analysis revealed polyphenols and flavonoids. CONCLUSION: Taken together, these results support traditional use of B.orthobotrys as potent anti-arthritic agent that may be proposed for rheumatoid arthritis treatment.
[Mh] MeSH terms primary: Antirheumatic Agents/therapeutic use
Arthritis, Experimental/drug therapy
Arthritis, Rheumatoid
Berberis/chemistry
Phytotherapy
Plant Extracts/therapeutic use
Polyphenols/therapeutic use
[Mh] MeSH terms secundary: Albumins/metabolism
Animals
Antioxidants/analysis
Antioxidants/pharmacology
Antioxidants/therapeutic use
Antirheumatic Agents/pharmacology
Arthritis, Rheumatoid/blood
Arthritis, Rheumatoid/drug therapy
Cattle
Cell Membrane/drug effects
Erythrocytes
Female
Flavonoids/analysis
Flavonoids/pharmacology
Flavonoids/therapeutic use
Formaldehyde
Freund's Adjuvant
Male
Plant Extracts/chemistry
Plant Extracts/pharmacology
Plant Structures
Polyphenols/analysis
Polyphenols/pharmacology
Protein Denaturation
Rats, Sprague-Dawley
Rheumatoid Factor/blood
Serum Albumin/metabolism
Turpentine
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Albumins); 0 (Antioxidants); 0 (Antirheumatic Agents); 0 (Flavonoids); 0 (Plant Extracts); 0 (Polyphenols); 0 (Serum Albumin); 1HG84L3525 (Formaldehyde); 8006-64-2 (Turpentine); 9007-81-2 (Freund's Adjuvant); 9009-79-4 (Rheumatoid Factor)
[Em] Entry month:1709
[Cu] Class update date: 170901
[Lr] Last revision date:170901
[Js] Journal subset:IM
[Da] Date of entry for processing:170720
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1879-9

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[PMID]: 28698879
[Au] Autor:He Y; Xiao H; Deng C; Fan G; Qin S; Peng C
[Ad] Address:College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
[Ti] Title:Complete Chloroplast Genome Sequence of Franch. and Its Evolutionary History.
[So] Source:Biomed Res Int;2017:8201836, 2017.
[Is] ISSN:2314-6141
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The Franch. is an important medicinal plant from the Ranunculales. We used next generation sequencing technology to determine the complete chloroplast genome of . This genome is 155,484 bp long with 38.17% GC content. Two 26,758 bp long inverted repeats separated the genome into a typical quadripartite structure. The chloroplast genome consists of 128 gene loci, including eight rRNA gene loci, 28 tRNA gene loci, and 92 protein-coding gene loci. Most of the SSRs in are poly-A/T. The numbers of mononucleotide SSRs in and other Ranunculaceae species are fewer than those in Berberidaceae species, while the number of dinucleotide SSRs is greater than that in the Berberidaceae. diverged from other Ranunculaceae species an estimated 81 million years ago (Mya). The divergence between Ranunculaceae and Berberidaceae was ~111 Mya, while the Ranunculales and Magnoliaceae shared a common ancestor during the Jurassic, ~153 Mya. Position 104 of the protein was identified as a positively selected site, indicating possible selection for the photosystem-chlororespiration system in . In summary, the complete sequencing and annotation of the chloroplast genome will facilitate future studies on this important medicinal species.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170716
[Lr] Last revision date:170716
[St] Status:In-Process
[do] DOI:10.1155/2017/8201836

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[PMID]: 28693796
[Au] Autor:Ayati SH; Fazeli B; Momtazi-Borojeni AA; Cicero AFG; Pirro M; Sahebkar A
[Ad] Address:Immunology Research Center, Department of Immunology, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran.
[Ti] Title:Regulatory effects of berberine on microRNome in Cancer and other conditions.
[So] Source:Crit Rev Oncol Hematol;116:147-158, 2017 Aug.
[Is] ISSN:1879-0461
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Berberine (BBR) is an isoquinoline alkaloid found in different plant families such as Berberidaceae, Ranunculaceae, and Papaveraceae. BBR is well-known for its anti-inflammatory, lipid-modifying, anticancer, anti-diabetic, antibacterial, antiparasitic and fungicide activities. Multiple pharmacological actions of BBR stem from different molecular targets of this phytochemical. MicroRNAs (miRs) are single-stranded, evolutionary conserved, small non-coding RNA molecules with a length of 19-23 nucleotides that are involved in RNA silencing and post-transcriptional regulation of gene expression through binding to the 3'-untranslated region (3'UTR) of target mRNA. MiRs emerged as important regulatory elements in almost all biological processes like cell proliferation, apoptosis, differentiation and organogenesis, and numerous human diseases such as cancer and diabetes. BBR was shown to regulate the expression of miRs in several diseases. Here, we reviewed the target miRs of BBR and the relevance of their modulation for the potential treatment of serious human diseases like multiple myeloma, hepatocellular carcinoma, colorectal cancer, gastric cancer, ovarian cancer and glioblastoma. The role of miR regulation in the putative anti-diabetic effects of BBR is discussed, as well.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1707
[Cu] Class update date: 170711
[Lr] Last revision date:170711
[St] Status:In-Process

  10 / 236 MEDLINE  
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[PMID]: 28656092
[Au] Autor:Rahimi-Madiseh M; Lorigoini Z; Zamani-Gharaghoshi H; Rafieian-Kopaei M
[Ad] Address:Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
[Ti] Title:: specifications and traditional uses.
[So] Source:Iran J Basic Med Sci;20(5):569-587, 2017 May.
[Is] ISSN:2008-3866
[Cp] Country of publication:Iran
[La] Language:eng
[Ab] Abstract:The medicinal plants from genus are particularly important in traditional medicine and the food basket of Iranians. Given various plants from genus and their economic, nutritional, and medicinal status in Iran, this study seeks to investigate the findings of recent studies on the phytochemical characteristics, specifications, and uses of . In this review article, 350 articles were initially retrieved from reliable scientific databases using relevant search terms. Then, 230 articles were selected and 120 were excluded after a primary analysis. Finally, 98 articles related to the subject under study were meticulously examined and the required data were extracted and classified according to the research purposes. The findings were divided into eight separate sections: Introducing Berberidaceae family, different species of Berberis, pharmaceutical organs, nutrition facts and minerals, the antioxidants and alkaloids compounds in fruit and other organs, action mechanisms of preventing and treating diseases, traditional uses of , and its properties reported by recent studies. The results briefly indicate that contains a large number of phytochemical materials including ascorbic acid, vitamin K, several triterpenoids, more than 10 phenolic compounds and more than 30 alkaloids. Therefore may have anti-cancer, anti-inflammatory, antioxidant, antidiabetic, antibacterial, analgesic and anti-nociceptive and hepato-protective effects. Regarding the use of different organs of in traditional medicine and their confirmed effects in the recent studies, it is possible to use different organs of , especially fruit, to develop new drugs.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1706
[Cu] Class update date: 170816
[Lr] Last revision date:170816
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.22038/IJBMS.2017.8690


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