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[PMID]: 29447950
[Au] Autor:Maleki T; Akhani H
[Ad] Address:Halophytes and C(4) Plants Research Laboratory, Department of Plant Science, School of Biology, University of Tehran, P.O. Box 14155-6455, Tehran, Iran.
[Ti] Title:Ethnobotanical and ethnomedicinal studies in Baluchi tribes: A case study in Mt. Taftan, southeastern Iran.
[So] Source:J Ethnopharmacol;217:163-177, 2018 Feb 12.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOBOTANICAL RELEVANCE: From ancient times, the applied use of herbs has been common among indigenous people throughout the world. The present survey is a regional ethnobotanical study of Baluchi tribes living in the Mt. Taftan area, Sistan and Baluchistan Province, southeastern Iran. The aim of this study was to document all traditional knowledge and analyze the medicinal plants used in area and also to identify significant plant species for future pharmacological study. MATERIALS AND METHODS: Local knowledge was obtained through semi structured and open interviews, in which 51 informants were interviewed. Data were analyzed with Informant Agreement Relative (IAR) and Frequency of Citation (FC) indices. RESULTS: A total number of 106 taxa of medicinal plants were collected from ten villages from the surrounding plains and highlands of Mt. Taftan, out of 446 plant taxa collected or reported as native in the area. Most plants belong to the Irano-Turanian phytogeographical region in which Asteraceae (15%), Lamiaceae (11%), Fabaceae (8%), Rosaceae (7%), Apiaceae (7%) and Brassicaceae (5%) are those predominantly used. The regression analysis shows that families Apiaceae, Lamiaceae, Solanaceae and Rosaceae are more highly used as medicinal than species rich families such as Asteraceae and Fabaceae, which are the richest families in the Iranian flora. The highest FC was recorded for Artemisia spp. (41) and Berberis integerrima (40). The highest IAR Index was obtained for stings (0.86), followed by disorders in the circulatory system (0.7), dental problems (0.70) and injuries (0.69). Comparing our data with major ethnobotanical references in Iran revealed that medicinal applications of 34 taxa have not been cited, including Hyoscyamus malekianus, a local endemic plant using for ailments of toothache and worms. The toxicity of the endemic Semenovia suffruticosa is also reported. CONCLUSION: As a result of this study we conclude that Taftan area harbours many plant species for which indigenous knowledge provides a background of medicinal importance. The high percentage of medicinal plants proportional to the native flora is 23.8%, compared to the world percentage of 17.1%, is an indication of the rich knowledge and relationship of isolated Baluchi tribes living in Mt. Taftan to the local flora growing in their surroundings. This rich knowledge should be highly regarded as a cultural and ethnobotanical heritage. Furthermore, ethnobotanical results show some weak interrelation between Baluchi tribes living in Iran and Pakistan, probably because of a different flora and/or unfavourable environmental conditions and perhaps local conflicts which might have reduced active cultural exchange.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:Publisher

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[PMID]: 29393562
[Au] Autor:Zhu X; Jiao M; Guo J; Liu P; Tan C; Yang Q; Zhang Y; Thomas Voegele R; Kang Z; Guo J
[Ad] Address:State Key Laboratory of Crop Stress Biology for Arid Areas, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, 712100, China.
[Ti] Title:A novel MADS-box transcription factor PstMCM1-1 is responsible for full virulence of Puccinia striiformis f. sp. tritici.
[So] Source:Environ Microbiol;, 2018 Feb 02.
[Is] ISSN:1462-2920
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:In many eukaryotes, transcription factor MCM1 gene plays crucial roles in regulating mating processes and pathogenesis by interacting with other co-factors. However, little is known about the role of MCM1 in rust fungi. Here, we identified two MCM1 orthologs, PstMCM1-1 and PstMCM1-2, in the stripe rust pathogen Puccinia striiformis f. sp. tritici (Pst). Sequence analysis indicated that both PstMCM1-1 and PstMCM1-2 contain conserved MADS domains and that PstMCM1-1 belongs to a group of SRF-like proteins that are evolutionarily specific to rust fungi. Yeast two-hybrid assays indicated that PstMCM1-1 interacts with transcription factors PstSTE12 and PstbE1. PstMCM1-1 was found to be highly induced during early infection stages in wheat and during pycniospore formation on the alternate host barberry (Berberis shensiana). PstMCM1-1 could complement the lethal phenotype and mating defects in a mcm1 mutant of Saccharomyces cerevisiae. In addition, it partially complemented the defects in appressorium formation and plant infection in a Magnaporthe oryzae Momcm1 mutant. Knock down of PstMCM1-1 resulted in a significant reduction of hyphal extension and haustorium formation and the virulence of Pst on wheat. Our results suggest that PstMCM1-1 plays important roles in the regulation of mating and pathogenesis of Pst most likely by interacting with co-factors.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180223
[Lr] Last revision date:180223
[St] Status:Publisher
[do] DOI:10.1111/1462-2920.14054

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[PMID]: 29411090
[Au] Autor:Porru E; Franco P; Calabria D; Spinozzi S; Roberti M; Caliceti C; Roda A
[Ad] Address:Department of Chemistry "Giacomo Ciamician", University of Bologna, Via Selmi 2, 40126, Bologna, Italy.
[Ti] Title:Combined analytical approaches to define biodistribution and biological activity of semi-synthetic berberrubine, the active metabolite of natural berberine.
[So] Source:Anal Bioanal Chem;, 2018 Feb 07.
[Is] ISSN:1618-2650
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:Berberine (BBR) is a natural alkaloid obtained from Berberis species plants, known for its protective effects against several diseases. Among the primary BBR metabolites, berberrubine (M1) showed the highest plasma concentration but few and conflicting data are available regarding its concentration in biological fluids related to its new potential activity on vascular cells. A combined analytical approach was applied to study biodistribution of M1 in comparison with BBR. The optimization of sample clean-up combined with a fully validated HPLC-ESI-MS/MS tailored for M1 allows sufficient detectability and accuracy to be reached in the different studied organs even when administered at low dose, comparable to that assumed by human. A predictive human vascular endothelial cell-based assay to measure intracellular xanthine oxidase has been developed and applied to study unexplored activities of M1 alongside other common activities. Results showed that oral M1 treatment exhibits higher plasma levels than BBR, reaching maximum concentration 400-fold higher than BBR (204 vs 0.5 ng/mL); moreover, M1 exhibits higher concentrations than BBR also in all the biological compartments analyzed. Noteworthy, the two compounds follow two different excretion routes: M1 through urine, while BBR through feces. In vitro studies demonstrated that M1 inhibited intracellular xanthine oxidase activity, one of the major sources of reactive oxygen species in vasculature, with an IC50 = 9.90 ± 0.01 µg/mL and reduced the expression of the inflammatory marker ICAM-1. These peculiar characteristics allow new perspectives to be opened up for the direct use of M1 instead of BBR in endothelial dysfunction treatment.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180207
[Lr] Last revision date:180207
[St] Status:Publisher
[do] DOI:10.1007/s00216-018-0884-2

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[PMID]: 29350661
[Au] Autor:Di Pierro F; Putignano P; Villanova N
[Ad] Address:Scientific Department, Velleja Research, Milan, Italy. f.dipierro@vellejaresearch.com.
[Ti] Title:Retrospective analysis of the effects of a highly standardized mixture of Berberis aristata, Silybum marianum, and monacolins K and KA in diabetic patients with dyslipidemia.
[So] Source:Acta Biomed;88(4):462-469, 2018 Jan 16.
[Is] ISSN:0392-4203
[Cp] Country of publication:Italy
[La] Language:eng
[Ab] Abstract:BACKGROUND: Berberine, an alkaloid with both glucose- and cholesterol-lowering action, is also characterized by an anti-diarrheal effect. Consequently, berberine-based therapies are recommended for diabetic patients with irritable bowel syndrome (IBS) or gut discomfort caused by metformin. AIM: As the anti-glycemic and cholesterol-lowering action of berberine is improved by co-administration with P-glycoprotein inhibitors and naturally derived statins, we have analyzed the effect of the food supplement Berberol®K (hereafter referred to as BSM) containing, berberine, silymarin, and a highly standardized red yeast rice containing monacolins K and KA in the ratio 1:1 but no secondary monacolins, dehydromonacolins, or citrinin (Monakopure™-K20). METHODS: We retrospectively evaluated the effects of BSM in 59 diabetic patients with dyslipidemia and compared the results to those obtained in patients without treatment. Enrolled subjects had a diagnosis of IBS (and diarrhea), had diarrhea caused by metformin, or were statin intolerant. RESULTS: After 6 months of BSM treatment, significant reductions of approximately 5%, 23%, 31%, and 20% were observed in glycated hemoglobin (HbA1c), total cholesterol (TC), low density lipoprotein-cholesterol (LDL), and triglyceride (TG) levels, respectively, and only five of the 31 treated subjects reported diarrhea compared with 22 of the 28 untreated patients. Regarding safety, treatment with BSM did not significant modify creatine phosphokinase (CPK), creatine, aspartate aminotransferase (AST) or alanine aminotransferase (ALT). CONCLUSION: BSM is a safe and effective food supplement likely useful as add-on therapy in diabetic subjects with dyslipidemia, especially if they are statin intolerant or with diarrhea caused by IBS or metformin.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180119
[Lr] Last revision date:180119
[St] Status:In-Data-Review
[do] DOI:10.23750/abm.v88i4.5851

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[PMID]: 29335865
[Au] Autor:Tan R; Lee YJ; Cho KW; Kang DG; Lee HS
[Ad] Address:College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea.
[Ti] Title:Beneficial effect of Berberis amurensis Rupr. on penile erection.
[So] Source:Chin J Integr Med;, 2018 Jan 15.
[Is] ISSN:1672-0415
[Cp] Country of publication:China
[La] Language:eng
[Ab] Abstract:OBJECTIVE: To investigate whether the methanol extract of Berberis amurensis Rupr. (BAR) augments penile erection using in vitro and in vivo experiments. METHODS: The ex vivo study used corpus cavernosum strips prepared from adult male New Zealand White rabbits. In in vivo studies for intracavernous pressure (ICP), blood pressure, mean arterial pressure (MAP), and increase of peak ICP were continuously monitored during electrical stimulation of Sprague-Dawley rats. RESULTS: Preconstricted with phenylephrine (PE) in isolated endotheliumintact rabbit corus cavernosum, BAR relaxed penile smooth muscle in a dose-dependent manner, which was inhibited by pretreatment with NG-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, and H-[1,2,4]-oxadiazole-[4,3-α]-quinoxalin-1-one, a soluble guanylyl cclase inhibitor. BAR signifificantly relaxed penile smooth muscles dose-dependently in ex vivo, and this was inhibited by pretreatment with L-NAME H-[1,2,4]-oxadiazole-[4,3-α]-quinoxalin-1-one. BAR-induced relaxation was significantly attenuated by pretreatment with tetraethylammonium (TEA, P<0.01), a nonselective K channel blocker, 4-aminopyridine (4-AP, P<0.01), a voltage-dependent K+ channel blocker, and charybdotoxin (P<0.01), a large and intermediate conductance Ca sensitive-K channel blocker, respectively. BAR induced an increase in peak ICP, ICP/MAP ratio and area under the curve dose dependently. CONCLUSIONS: BAR augments penile erection via the nitric oxide/cyclic guanosine monophosphate system and Ca sensitive-K (BKCa and IKCa) channels in the corpus cavernosum.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180116
[Lr] Last revision date:180116
[St] Status:Publisher
[do] DOI:10.1007/s11655-017-2920-z

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[PMID]: 29226496
[Au] Autor:Mastretta-Yanes A; Xue AT; Moreno-Letelier A; Jorgensen TH; Alvarez N; Piñero D; Emerson BC
[Ad] Address:CONACYT - CONABIO, Comisión Nacional para el Conocimiento y Uso de la Biodiversidad, México, DF, México.
[Ti] Title:Long-term in situ persistence of biodiversity in tropical sky islands revealed by landscape genomics.
[So] Source:Mol Ecol;, 2017 Dec 11.
[Is] ISSN:1365-294X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Tropical mountains are areas of high species richness and endemism. Two historical phenomena may have contributed to this: (i) fragmentation and isolation of habitats may have promoted the genetic differentiation of populations and increased the possibility of allopatric divergence and speciation and (ii) the mountain areas may have allowed long-term population persistence during global climate fluctuations. These two phenomena have been studied using either species occurrence data or estimating species divergence times. However, only few studies have used intraspecific genetic data to analyse the mechanisms by which endemism may emerge at the microevolutionary scale. Here, we use landscape analysis of genomic SNP data sampled from two high-elevation plant species from an archipelago of tropical sky islands (the Trans-Mexican Volcanic Belt) to test for population genetic differentiation, synchronous demographic changes and habitat persistence. We show that genetic differentiation can be explained by the degree of glacial habitat connectivity among mountains and that mountains have facilitated the persistence of populations throughout glacial/interglacial cycles. Our results support the ongoing role of tropical mountains as cradles for biodiversity by uncovering cryptic differentiation and limits to gene flow.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180116
[Lr] Last revision date:180116
[St] Status:Publisher
[do] DOI:10.1111/mec.14461

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[PMID]: 29186770
[Au] Autor:Kukula-Koch W; Kruk-Slomka M; Stepnik K; Szalak R; Biala G
[Ad] Address:Chair and Department of Pharmacognosy with Medicinal Plant Unit, Medical University in Lublin, 20-093 Lublin, Poland
[Ti] Title:The Evaluation of Pro-Cognitive and Antiamnestic Properties of Berberine and Magnoflorine Isolated from Barberry Species by Centrifugal Partition Chromatography (CPC), in Relation to QSAR Modelling.
[So] Source:Int J Mol Sci;18(12), 2017 11 24.
[Is] ISSN:1422-0067
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Civilization diseases associated with memory disorders are important health problems occurring due to a prolonged life span. The manuscript shows the results of an in vivo study targeting the emergence of two drug candidates with anti-amnestic properties. The preceding quantitative structure-activity relationship (QSAR) studies provided information on the ability of berberine and magnoflorine to cross the blood-brain barrier (BBB). In the light of these findings, both compounds were purified from crude plant extracts of barberries: berberine-from using a method published earlier, and magnoflorine-from by centrifugal partition chromatography (solvent system: ethyl acetate:butanol:water-0.6:1.5:3 / / ). Both the compounds were evaluated for their memory enhancing and scopolamine inhibitory properties in an in vivo passive avoidance (PA) test on mice towards short-term and long-term memory. Cognition enhancing properties were observed at the following doses: 5 mg/kg (i.p.) for berberine and 20 mg/kg (i.p.) for magnoflorine. In addition, both the tested isoquinolines with the co-administered scopolamine were found to block long-term but not short-term memory impairment. No influence on the locomotor activity was observed for the tested doses. The results confirmed a marked central activity of magnoflorine and showed the necessity to lower the dosage of berberine. Optimized purification conditions have been elaborated for magnoflorine.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180109
[Lr] Last revision date:180109
[St] Status:In-Process

  8 / 462 MEDLINE  
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[PMID]: 29191238
[Au] Autor:Ahmad KS; Hamid A; Nawaz F; Hameed M; Ahmad F; Deng J; Akhtar N; Wazarat A; Mahroof S
[Ad] Address:Department of Botany, University of Poonch Rawalakot, Azad Kashmir, 12350, Pakistan. shafiquebot@yahoo.com.
[Ti] Title:Ethnopharmacological studies of indigenous plants in Kel village, Neelum Valley, Azad Kashmir, Pakistan.
[So] Source:J Ethnobiol Ethnomed;13(1):68, 2017 Dec 01.
[Is] ISSN:1746-4269
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: This explorative study was undertaken for the first time in Kel village located in the Upper Neelum Valley, Azad Kashmir, Pakistan. The purpose was to document the indigenous knowledge of the native people used in the preparation of herbal medicines. METHODS: To get the data on traditional uses of medicinal plants, 20 informants were interviewed. Quantitative ethnobotanical indices, i.e., use value (UV), relative frequencies of citation (RFC), informant consensus factor (Fic), fidelity level (FL), data matrix ranking (DMR), preference ranking (PR), and jaccard index (JI), were calculated for the recorded medicinal plants. RESULTS: A total of 50 medicinal plants belonging to 33 families used in 13 disease categories were documented. Leaves were the frequently used plant parts, and decoction was the commonly used method for herbal medicine. Plants with high use value were Berberis lycium (2.05), Impatiens glandulifera (1.95), Artemisia scoparia (1.75), Ageratum conozoides (1.75), and Achillea millefolium (1.7). The highest RFC value was calculated for Berberis lycium (0.75), Cynoglossum lanceolatum (0.65), and Impatiens glandulifera and Achillea millefolium (0.60 each). The maximum informant consensus factor was for urinary system, cardiac diseases, baldness, and abortion and miscarriage (1.00). Berberis lyceum (95%) used in jaundice, hepatitis, typhoid, fever, and tuberculosis disorders. Plants with maximum fidelity level (FL) were Berberis lycium (95%) followed by Dioscorea bulbifera, Impatiens glandulifera, and Artemisia vulgaris (90%). Olea ferruginea was the most multipurpose plant and exports (21.2%) was the leading threat in the area. The pearson correlation coefficient (0.500) showed a positive correlation between the use value and relative frequency of citation. CONCLUSION: The present study provides useful information about traditional uses of medicinal plants used by local communities in different ailments. The plants with the highest use values could be employed in pharmacological research and biotechnological approaches in order to achieve adequate revenue. Some of the plants in the study area are facing high threats of becoming rare, and conservation initiatives are needed to conserve them for sustainable management in the region.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171220
[Lr] Last revision date:171220
[St] Status:In-Process
[do] DOI:10.1186/s13002-017-0196-1

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[PMID]: 29142419
[Au] Autor:Nimisha; Rizvi DA; Fatima Z; Neema; Kaur CD
[Ad] Address:Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus, Lucknow, Uttar Pradesh, India.
[Ti] Title:Antipsoriatic and Anti-inflammatory Studies of Extract Loaded Nanovesicular Gels.
[So] Source:Pharmacogn Mag;13(Suppl 3):S587-S594, 2017 Oct.
[Is] ISSN:0973-1296
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Objective: Novel nanovesicular gel of extract was developed and evaluated for its anti-inflammatory and antipsoriatic activity. Materials and Methods: Transferosomes were prepared using soya phosphatidylcholine and edge activators (Tween 80, Span 80, and sodium deoxycholate) by a modified lipid film hydration technique using rotary evaporator and evaluated for various parameters. The quantification and standardization of extract have been carried out using its alkaloid content as berberine as biomarker. Topical application of imiquimod (IMQ) (immune modifier) on the shaved back of mice developed psoriasis-like inflammation followed by histopathological study of inflamed skin. Results: The size of transferosomes was in the range of 265-345 nm whereas polydispersity index ranges from 0.10 to 0.63, and for zeta potential, it was from -19.3 to -43.3 mV. Transferosomes were further added to Carbopol 934P for gel formation and subsequently evaluated for their physicochemical properties. Their efficacy against inflammation, IMQ-induced psoriasis, and skin sensitivity was compared with conventional formulation (commercial formulation-Angle Gloss, Phytolab Pvt. Ltd.). Percent inhibition of edema by transferosomal gel (55.76%) was more as compared to conventional gel of extract (33.5%) found out by Carrageenan-induced paw edema method. Primary irritation index was found to be <0.4 inferring its safe use for topical formulation. Conclusion: Histopathological report showed that, in psoriasis-induced animal treated with topical application of extract loaded transferosomal gel showed a marked reduction in thickness of epidermis, length of rete ridges as compared to conventional gel formulation. It can be inferred that extract loaded transferosomal gel can function as potential anti-inflammatory and antipsoriatic formulation. SUMMARY: The objective of the present research work was to prepare extracts (roots, ethanolic 70%v/v) loaded transferosomal gel, to perform characterization and evaluation of their efficacy against inflammation as well as imiquimod (IMQ)-induced psoriasis in animalsThe remarkable enhancement in the release efficiency of extract loaded transferosomal gel resulted in improved anti-inflammatory activity. The prepared novel formulation of has also shown its efficacy against IMQ-induced psoriasis. SPC: Soyaphosphatidylcholine, PDI: Polydispersity index, IMQ: Imiquimod, EA: Edge activator, BE: Berberine, TEM: Transmission electron microscopy, PBS: Phosphate buffered saline, H and E: Hematoxylin and eosin, ZP: Zeta potential, EE: Entrapment efficiency.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171119
[Lr] Last revision date:171119
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/pm.pm_210_17

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[PMID]: 29113353
[Au] Autor:Lin CY; Hsieh PL; Liao YW; Peng CY; Lu MY; Yang CH; Yu CC; Liu CM
[Ad] Address:Department of Oral and Maxillofacial Surgery, Chi Mei Hospital, Tainan, Taiwan.
[Ti] Title:Berberine-targeted miR-21 chemosensitizes oral carcinomas stem cells.
[So] Source:Oncotarget;8(46):80900-80908, 2017 Oct 06.
[Is] ISSN:1949-2553
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Cancer recurrence and chemoresistance are two major obstacles to the treatment of oral squamous cell carcinomas (OSCC). And cancer stem cells (CSCs) have been found to possess tumor initiating, self-renewal and metastasis abilities, resulting in the relapse and chemoresistance of OSCC. In the present study, we investigated the anti-CSCs effect of berberine, a phenanthrene alkaloid isolated from the Berberis genus. Our results demonstrated that berberine dose dependently downregulated the oncogenicity , including ALDH1 activity, self-renewal property, and colony formation and invasion abilities as well as potentiated chemosensitivity of OSCC-CSCs. In addition, tumor growth in mice was attenuated after oral gavage treatment of berberine. We showed that the expression of miR-21 was suppressed following administration of berberine in OSCC-CSCs. And inhibition of endogenous miR-21 reduced the characteristics of CSCs, including self-renewal, migration, invasion capabilities and ALDH1 activity. Taken together, we demonstrated the anti-CSC effect of berberine in oral cancer and its potential to serve as adjuvant to traditional chemotherapy to improve treatment effect.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171110
[Lr] Last revision date:171110
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.18632/oncotarget.20723


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