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Search on : Berylliosis [Words]
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[PMID]: 29374638
[Au] Autor:Moloney DP; Chawke L; Crowley MT; O'Connor TM
[Ad] Address:Department of Respiratory Medicine, Mercy University Hospital, Cork, Munster, Ireland.
[Ti] Title:Fluctuating hypercalcaemia caused by cavitary pulmonary infection.
[So] Source:BMJ Case Rep;2018, 2018 Jan 26.
[Is] ISSN:1757-790X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Hypercalcaemia occurs in many granulomatous diseases. Among them, sarcoidosis and tuberculosis are the most common causes. Other causes include berylliosis, coccidioidomycosis, histoplasmosis, Crohn's disease, silicone-induced granulomas, cat-scratch disease, Wegener's granulomatosis and pneumonia. Hypercalcaemia in granulomatous disease occurs as a consequence of dysregulated production of 1,25-(OH)2 D3 (calcitriol) by activated macrophages in granulomas. Hypercalcaemia in patients with infection has been reported in 0%-28% of cases. Uncultured bronchoalveolar lavage cells from patients with produce greater amounts of calcitriol compared with controls. Although Nayar described hypercalcaemia in a case of sepsis associated with intravesical Bacille Calmette Guerin therapy, there are no published reports describing hypercalcaemia in patients with pulmonary infection. We describe a patient with cavitary pulmonary infection with sustained hypercalcaemia that fluctuated and recurred repeatedly over the course of therapy, ultimately culminating in normalisation of serum calcium when therapy had led to cure. Treatment consisted of antituberculous therapy, oral corticosteroids and intravenous bisphosphonates with a favourable outcome.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180128
[Lr] Last revision date:180128
[St] Status:In-Process

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[PMID]: 29080069
[Au] Autor:Day BJ; Huang J; Barkes BQ; Gillespie M; Li L; Maier LA
[Ad] Address:Department of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO, USA.
[Ti] Title:5-Aminosalicylic Acid Modulates the Immune Response in Chronic Beryllium Disease Subjects.
[So] Source:Lung;, 2017 Oct 27.
[Is] ISSN:1432-1750
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:INTRODUCTION: Chronic beryllium disease (CBD) is characterized by accumulation of macrophages and beryllium-specific CD4 T cells that proliferate and produce Th1 cytokines. 5-Amino salicylic acid (5-ASA) is currently used to treat inflammatory bowel disease and has both antioxidant and anti-inflammatory actions. We hypothesized that 5-ASA may be a beneficial therapeutic in CBD. METHODS: Seventeen CBD patients were randomized 3:1 to receive 5-ASA 500-mg capsules or placebo four times daily for 6 weeks orally. Primary study endpoints included changes in beryllium lymphocyte proliferation (BeLPT). Secondary endpoints included changes in bronchoalveolar lavage (BAL) fluid, cells, serum, and blood cell glutathione (GSH) levels, BAL cell TNF-α levels, lung function, and quality of life measures. RESULTS: 5-ASA decreased BAL cell BeLPT by 20% within the 5-ASA treatment group. No significant changes were observed in serum, PBMCs, BALF, or BAL cell GSH levels in either the 5-ASA or placebo treatment group. 5-ASA treatment decreased ex vivo Be-stimulated BAL cell TNF-α levels within the 5-ASA group and when compared to placebo. Significant improvements were noted in quality of life measurements with 5-ASA treatment. CONCLUSIONS: 5-ASA's ability to decrease BAL cell BeLPT and Be-stimulated BAL cell TNF-α levels suggests that 5-ASA may impact the beryllium-specific immune response in CBD. 5-ASA use in other non-infectious granulomatous lung diseases, such as sarcoidosis, may prove to be a useful alternative treatment to corticosteroids for those with mild to moderate disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171028
[Lr] Last revision date:171028
[St] Status:Publisher
[do] DOI:10.1007/s00408-017-0062-x

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[PMID]: 28872302
[Au] Autor:Ermakov YA; Kamaraju K; Dunina-Barkovskaya A; Vishnyakova KS; Yegorov YE; Anishkin A; Sukharev S
[Ad] Address:Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences , Leninsky Prospect 31, Moscow 117071, Russia.
[Ti] Title:High-Affinity Interactions of Beryllium(2+) with Phosphatidylserine Result in a Cross-Linking Effect Reducing Surface Recognition of the Lipid.
[So] Source:Biochemistry;56(40):5457-5470, 2017 Oct 10.
[Is] ISSN:1520-4995
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Beryllium has multiple industrial applications, but its manufacture is associated with a serious occupational risk of developing chronic inflammation in the lungs known as berylliosis, or chronic beryllium disease. Although the Be -induced abnormal immune responses have recently been linked to a specific MHC-II allele, the nature of long-lasting granulomas is not fully understood. Here we show that Be binds with a micromolar affinity to phosphatidylserine (PS), the major surface marker of apoptotic cells. Isothermal titration calorimetry indicates that, like that of Ca , binding of Be to PS liposomes is largely entropically driven, likely by massive desolvation. Be exerts a compacting effect on PS monolayers, suggesting cross-linking through coordination by both phosphates and carboxyls in multiple configurations, which were visualized in molecular dynamics simulations. Electrostatic modification of PS membranes by Be includes complete neutralization of surface charges at ∼30 µM, accompanied by an increase in the boundary dipole potential. The data suggest that Be can displace Ca from the surface of PS, and being coordinated in a tight shell of four oxygens, it can mask headgroups from Ca -mediated recognition by PS receptors. Indeed, 48 µM Be added to IC-21 cultured macrophages specifically suppresses binding and engulfment of PS-coated silica beads or aged erythrocytes. We propose that Be adsorption at the surface of apoptotic cells may potentially prevent normal phagocytosis, thus causing accumulation of secondary necrotic foci and the resulting chronic inflammation.
[Mh] MeSH terms primary: Beryllium/metabolism
Phosphatidylserines/metabolism
[Mh] MeSH terms secundary: Macrophages/metabolism
Molecular Conformation
Molecular Dynamics Simulation
Phosphatidylserines/chemistry
Static Electricity
Surface Properties
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Phosphatidylserines); OW5102UV6N (Beryllium)
[Em] Entry month:1710
[Cu] Class update date: 171019
[Lr] Last revision date:171019
[Js] Journal subset:IM
[Da] Date of entry for processing:170906
[St] Status:MEDLINE
[do] DOI:10.1021/acs.biochem.7b00644

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[PMID]: 28805487
[Au] Autor:Roncati L; Barbolini G
[Ad] Address:a Department of Diagnostic and Clinical Medicine and of Public Health , University of Modena and Reggio Emilia , Modena , MO , Italy.
[Ti] Title:State-of-the-art nanopathological diagnostics.
[So] Source:Ultrastruct Pathol;41(5):309-311, 2017 Sep-Oct.
[Is] ISSN:1521-0758
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:The nanopathological diagnostics (ND) is an ultra-specialized branch of pathological anatomy aimed to identify the nanoparticles of metallic, semimetallic, or nonmetallic elements in the inorganic particulate matter present inside pathological tissues, even on the nanometer scale. ND exploits an environmental scanning electron microscope, connected to an X-ray microprobe mounted on an energy-dispersive spectrometer. The searching of nanoparticles can be performed on paraffin-embedded material, omitting emissions of black overlay and plating procedures. The technique is highly sensitive and specific, reproducible and rapid, covering an entire operating cycle in few hours. Nowadays, ND finds many applications: (I) intratumor detection of heavy metals and endocrine metal disruptors; (II) identification of pathogenic nanoparticles in medical or veterinary drugs and devices, cosmetics, household products, and foodstuffs; (III) differential diagnosis of sarcoid-type granulomas (berylliosis, baritosis) and foreign body granulomas (prosthetic, iatrogenic); (IV) attestation of occupational disease correlating the datum with the occupational risk (anthracosis, asbestosis, bauxite fibrosis, byssinosis, chalicosis, siderosis, silicosis, stannosis, talcosis); and (V) forensic investigations to ascertain a causal link between disease and environmental, military, or work exposure. In addition to filling a knowledge gap, ND offers to the pathologist a current research field, with particular reference to the impact of occupational and environmental pollution on the human health and cancer.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170822
[Lr] Last revision date:170822
[St] Status:In-Process
[do] DOI:10.1080/01913123.2017.1358227

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[PMID]: 28794143
[Au] Autor:Ohshimo S; Guzman J; Costabel U; Bonella F
[Ad] Address:Dept of Emergency and Critical Care Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
[Ti] Title:Differential diagnosis of granulomatous lung disease: clues and pitfalls: Number 4 in the Series "Pathology for the clinician" Edited by Peter Dorfmüller and Alberto Cavazza.
[So] Source:Eur Respir Rev;26(145), 2017 Sep 30.
[Is] ISSN:1600-0617
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Granulomatous lung diseases are a heterogeneous group of disorders that have a wide spectrum of pathologies with variable clinical manifestations and outcomes. Precise clinical evaluation, laboratory testing, pulmonary function testing, radiological imaging including high-resolution computed tomography and often histopathological assessment contribute to make a confident diagnosis of granulomatous lung diseases. Differential diagnosis is challenging, and includes both infectious (mycobacteria and fungi) and noninfectious lung diseases (sarcoidosis, necrotising sarcoid granulomatosis, hypersensitivity pneumonitis, hot tub lung, berylliosis, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, rheumatoid nodules, talc granulomatosis, Langerhans cell histiocytosis and bronchocentric granulomatosis). Bronchoalveolar lavage, endobronchial ultrasound-guided transbronchial needle aspiration, transbronchial cryobiopsy, positron emission tomography and genetic evaluation are potential candidates to improve the diagnostic accuracy for granulomatous lung diseases. As granuloma alone is a nonspecific histopathological finding, the multidisciplinary approach is important for a confident diagnosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 170810
[Lr] Last revision date:170810
[St] Status:In-Process

  6 / 718 MEDLINE  
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[PMID]: 28071878
[Au] Autor:Occupational Safety and Health Administration (OSHA), Department of Labor
[Ti] Title:Occupational Exposure to Beryllium. Final rule.
[So] Source:Fed Regist;82(5):2470-757, 2017 01 09.
[Is] ISSN:0097-6326
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The Occupational Safety and Health Administration (OSHA) is amending its existing standards for occupational exposure to beryllium and beryllium compounds. OSHA has determined that employees exposed to beryllium at the previous permissible exposure limits face a significant risk of material impairment to their health. The evidence in the record for this rulemaking indicates that workers exposed to beryllium are at increased risk of developing chronic beryllium disease and lung cancer. This final rule establishes new permissible exposure limits of 0.2 micrograms of beryllium per cubic meter of air (0.2 [mu]g/m\3\) as an 8-hour time-weighted average and 2.0 [mu]g/m\3\ as a short-term exposure limit determined over a sampling period of 15 minutes. It also includes other provisions to protect employees, such as requirements for exposure assessment, methods for controlling exposure, respiratory protection, personal protective clothing and equipment, housekeeping, medical surveillance, hazard communication, and recordkeeping. OSHA is issuing three separate standards--for general industry, for shipyards, and for construction--in order to tailor requirements to the circumstances found in these sectors.
[Mh] MeSH terms primary: Berylliosis/prevention & control
Beryllium/adverse effects
Occupational Exposure/legislation & jurisprudence
Occupational Exposure/prevention & control
Occupational Health/legislation & jurisprudence
[Mh] MeSH terms secundary: Berylliosis/etiology
Humans
Protective Clothing
Respiratory Protective Devices
United States
United States Occupational Safety and Health Administration
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:OW5102UV6N (Beryllium)
[Em] Entry month:1701
[Cu] Class update date: 170118
[Lr] Last revision date:170118
[Js] Journal subset:T
[Da] Date of entry for processing:170111
[St] Status:MEDLINE

  7 / 718 MEDLINE  
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[PMID]: 27379608
[Au] Autor:Ginelliová A; Farkas D; Farkasová Iannaccone S; Vyhnálková V
[Ad] Address:Medico-Legal and Pathological-Anatomical Department of Health Care Surveillance Authority, Letná 47, 040 01, Kosice, Slovak Republic. e.ginelli@gmail.com.
[Ti] Title:Sudden unexpected death due to severe pulmonary and cardiac sarcoidosis.
[So] Source:Forensic Sci Med Pathol;12(3):319-23, 2016 Sep.
[Is] ISSN:1556-2891
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:In this paper we report the autopsy findings of a 57 year old woman who died unexpectedly at home. She had been complaining of shortness of breath, episodes of dry coughing, and nausea. Her past medical and social history was unremarkable. She had no previous history of any viral or bacterial disease and no history of oncological disorders. Autopsy revealed multiple grayish-white nodular lesions in the pleura and epicardial fat and areas resembling fibrosis on the cut surface of the anterior and posterior wall of the left ventricle and interventricular septum. Histological examination of the lungs and heart revealed multiple well-formed noncaseating epithelioid cell granulomas with multinucleated giant cells. Death was attributed to myocardial ischemia due to vasculitis of intramural coronary artery branches associated with sarcoidosis. Sarcoidosis is a multisystemic disease of unknown etiology characterized by the formation of noncaseating epithelioid cell granulomas in the affected organs and tissues. The diagnosis of sarcoidosis in this case was established when other causes of granulomatous disease such as tuberculosis, berylliosis, hypersensitivity pneumonitis, and giant cell myocarditis had been reasonably excluded.
[Mh] MeSH terms primary: Cardiomyopathies/complications
Death, Sudden/etiology
Sarcoidosis, Pulmonary/complications
Sarcoidosis/complications
[Mh] MeSH terms secundary: Arteritis/etiology
Arteritis/pathology
Cardiomyopathies/diagnosis
Coronary Vessels/pathology
Female
Humans
Middle Aged
Myocardial Ischemia/etiology
Sarcoidosis/diagnosis
Sarcoidosis, Pulmonary/diagnosis
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1702
[Cu] Class update date: 171107
[Lr] Last revision date:171107
[Js] Journal subset:IM
[Da] Date of entry for processing:160706
[St] Status:MEDLINE
[do] DOI:10.1007/s12024-016-9792-y

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[PMID]: 27364901
[Au] Autor:Naglav D; Buchner MR; Bendt G; Kraus F; Schulz S
[Ad] Address:Faculty of Chemistry, University of Duisburg-Essen, Universitätsstrasse 7, 45141, Essen, Germany.
[Ti] Title:Off the Beaten Track-A Hitchhiker's Guide to Beryllium Chemistry.
[So] Source:Angew Chem Int Ed Engl;55(36):10562-76, 2016 Aug 26.
[Is] ISSN:1521-3773
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:This Minireview aims to give an introduction to beryllium chemistry for all less-experienced scientists in this field of research. Up to date information on the toxicity of beryllium and its compounds are reviewed and several basic and necessary guidelines for a safe and proper handling in modern chemical research laboratories are presented. Interesting phenomenological observations are described that are related directly to the uniqueness of this element, which are also put into historical context. Herein we combine the contributions and experiences of many scientist that work passionately in this field. We want to encourage fellow scientists to reconcile the long-standing reservations about beryllium and its compounds and motivate intense research on this spurned element. Who on earth should be able to deal with beryllium and its compounds if not chemists?
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1607
[Cu] Class update date: 160824
[Lr] Last revision date:160824
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1002/anie.201601809

  9 / 718 MEDLINE  
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[PMID]: 27020917
[Au] Autor:Ogawa Y
[Ti] Title:Chemical poisonings, new and old.
[So] Source:Ind Health;54(2):99-100, 2016.
[Is] ISSN:1880-8026
[Cp] Country of publication:Japan
[La] Language:eng
[Mh] MeSH terms primary: Berylliosis/complications
Lead Poisoning/etiology
Lung Neoplasms/etiology
Occupational Diseases/etiology
Occupational Exposure/adverse effects
Printing
Toluidines/toxicity
Urinary Bladder Neoplasms/etiology
[Mh] MeSH terms secundary: Construction Industry
Humans
Japan
Metallurgy
[Pt] Publication type:EDITORIAL
[Nm] Name of substance:0 (Toluidines)
[Em] Entry month:1702
[Cu] Class update date: 170202
[Lr] Last revision date:170202
[Js] Journal subset:IM
[Da] Date of entry for processing:160330
[St] Status:MEDLINE
[do] DOI:10.2486/indhealth.54_201

  10 / 718 MEDLINE  
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[PMID]: 26977753
[Au] Autor:Baur X; Müller-Quernheim J
[Ad] Address:Institut für Arbeitsmedizin, Charité Universitätsmedizin Berlin, European Society for Environmental and Occupational Medicine (EOM).
[Ti] Title:Differenzialdiagnostische Aspekte der Sarkoidose anhand eines Fallberichts. [Case Report with Differential Diagnostic Aspects of Sarcoidosis].
[So] Source:Pneumologie;70(3):201-4, 2016 Mar.
[Is] ISSN:1438-8790
[Cp] Country of publication:Germany
[La] Language:ger
[Ab] Abstract:A 73-year-old non-atopic patient had developed at the age of 29 shortness of breath on exertion, general malaise, enlarged axillary lymph nodes and nodular cutaneous eruptions. Based on the presence of bihilar lymphadenopathy, the diagnosis of sarcoidosis was made at that time without any histological investigations and without taking detailed case history. Administration of systemic steroids resulted in remission. However, 12 years later, there was a relapse with alterations of lung parenchyma, followed by a more chronic course of the disorder. Since this relapse, an obstructive-restrictive ventilation defect requiring treatment has persisted till today. About five years ago and at the insistence of the patient, clarifying diagnostics were performed. The case shows the important role of a detailed case history including occupational history. Its failure not only led to disadvantages to the patient but also to incorrect social insurance handling and missing appropriate preventive measures with regard to co-workers.
[Mh] MeSH terms primary: Berylliosis/diagnostic imaging
Berylliosis/therapy
Diagnostic Errors/prevention & control
Sarcoidosis, Pulmonary/diagnosis
Sarcoidosis, Pulmonary/therapy
[Mh] MeSH terms secundary: Aged
Diagnosis, Differential
False Positive Reactions
Humans
Male
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1701
[Cu] Class update date: 170117
[Lr] Last revision date:170117
[Js] Journal subset:IM
[Da] Date of entry for processing:160316
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-101661


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