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[PMID]: 27992460
[Au] Autor:Fontaine V; Monteiro E; Brazhnikova E; Lesage L; Balducci C; Guibout L; Feraille L; Elena PP; Sahel JA; Veillet S; Lafont R
[Ad] Address:Sorbonne Universités, UPMC Univ Paris, INSERM, CNRS, Institut de la Vision, 17 Rue Moreau, Paris, France.
[Ti] Title:Norbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In Vivo.
[So] Source:PLoS One;11(12):e0167793, 2016.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The accumulation of N-retinylidene-N-retinylethanolamine (A2E, a toxic by-product of the visual pigment cycle) in the retinal pigment epithelium (RPE) is a major cause of visual impairment in the elderly. Photooxidation of A2E results in retinal pigment epithelium degeneration followed by that of associated photoreceptors. Present treatments rely on nutrient supplementation with antioxidants. 9'-cis-Norbixin (a natural diapocarotenoid, 97% purity) was prepared from Bixa orellana seeds. It was first evaluated in primary cultures of porcine retinal pigment epithelium cells challenged with A2E and illuminated with blue light, and it provided an improved photo-protection as compared with lutein or zeaxanthin. In Abca4-/- Rdh8-/- mice (a model of dry AMD), intravitreally-injected norbixin maintained the electroretinogram and protected photoreceptors against light damage. In a standard rat blue-light model of photodamage, norbixin was at least equally as active as phenyl-N-tert-butylnitrone, a free radical spin-trap. Chronic experiments performed with Abca4-/- Rdh8-/- mice treated orally for 3 months with norbixin showed a reduced A2E accumulation in the retina. Norbixin appears promising for developing an oral treatment of macular degeneration. A drug candidate (BIO201) with 9'-cis-norbixin as the active principle ingredient is under development, and its potential will be assessed in a forthcoming clinical trial.
[Mh] MeSH terms primary: Carotenoids/administration & dosage
Macular Degeneration/drug therapy
Photoreceptor Cells, Vertebrate/drug effects
Retinal Pigment Epithelium/drug effects
Retinoids/adverse effects
[Mh] MeSH terms secundary: ATP-Binding Cassette Transporters/genetics
Alcohol Oxidoreductases/genetics
Animals
Bixaceae/chemistry
Carotenoids/pharmacology
Cells, Cultured
Disease Models, Animal
In Vitro Techniques
Intravitreal Injections
Macular Degeneration/chemically induced
Macular Degeneration/genetics
Macular Degeneration/metabolism
Mice
Mice, Knockout
Plant Extracts/administration & dosage
Plant Extracts/chemistry
Plant Extracts/pharmacology
Rats
Retinal Pigment Epithelium/cytology
Swine
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (A2-E (N-retinylidene-N-retinylethanolamine)); 0 (Abca4 protein, mouse); 0 (Plant Extracts); 0 (Retinoids); 36-88-4 (Carotenoids); E8M59E17AI (norbixin); EC 1.1.- (Alcohol Oxidoreductases); EC 1.1.1.105 (Rdh8 protein, mouse)
[Em] Entry month:1707
[Cu] Class update date: 170713
[Lr] Last revision date:170713
[Js] Journal subset:IM
[Da] Date of entry for processing:161219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0167793

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[PMID]: 28212283
[Au] Autor:Chin KY; Abdul-Majeed S; Mohamed N; Ima-Nirwana S
[Ad] Address:Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Malaysia. chinkokyong@ppukm.ukm.edu.my.
[Ti] Title:The Effects of Tocotrienol and Lovastatin Co-Supplementation on Bone Dynamic Histomorphometry and Bone Morphogenetic Protein-2 Expression in Rats with Estrogen Deficiency.
[So] Source:Nutrients;9(2), 2017 Feb 15.
[Is] ISSN:2072-6643
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Both tocotrienol and statins are suppressors of the mevalonate pathway. Supplementation of tocotrienol among statin users could potentially protect them against osteoporosis. This study aimed to compare the effects of tocotrienol and lovastatin co-supplementation with individual treatments on bone dynamic histomorphometric indices and bone morphogenetic protein-2 (BMP-2) gene expression in ovariectomized rats. Forty-eight female Sprague-Dawley rats were randomized equally into six groups. The baseline was sacrificed upon receipt. All other groups were ovariectomized, except for the sham group. The ovariectomized groups were administered orally daily with (1) lovastatin 11 mg/kg/day alone; (2) tocotrienol derived from annatto bean (annatto tocotrienol) 60 mg/kg/day alone; (3) lovastatin 11 mg/kg/day, and annatto tocotrienol 60 mg/kg/day. The sham and ovariectomized control groups were treated with equal volume of vehicle. After eight weeks of treatment, the rats were sacrificed. Their bones were harvested for bone dynamic histomorphometry and BMP-2 gene expression. Rats supplemented with annatto tocotrienol and lovastatin concurrently demonstrated significantly lower single-labeled surface, but increased double-labeled surface, mineralizing surface, mineral apposition rate and bone formation rate compared to individual treatments ( < 0.05). There was a parallel increase in BMP-2 gene expression in the rats receiving combined treatment ( < 0.05). The combination of annatto tocotrienol and lovastatin exerted either additively or synergistically on selected bone parameters. In conclusion, tocotrienol can augment the bone formation and mineralization in rats receiving low-dose statins. Supplementation of tocotrienol in statin users can potentially protect them from osteoporosis.
[Mh] MeSH terms primary: Bone Morphogenetic Protein 2/metabolism
Bone and Bones/drug effects
Dietary Supplements
Estrogens/deficiency
Lovastatin/administration & dosage
Tocotrienols/administration & dosage
[Mh] MeSH terms secundary: Animals
Bixaceae/chemistry
Bone and Bones/metabolism
Carotenoids/chemistry
Female
Ovariectomy
Plant Extracts/chemistry
Rats
Rats, Sprague-Dawley
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Bmp2 protein, rat); 0 (Bone Morphogenetic Protein 2); 0 (Estrogens); 0 (Plant Extracts); 0 (Tocotrienols); 36-88-4 (Carotenoids); 6PQP1V1B6O (annatto); 9LHU78OQFD (Lovastatin)
[Em] Entry month:1706
[Cu] Class update date: 170619
[Lr] Last revision date:170619
[Js] Journal subset:IM
[Da] Date of entry for processing:170217
[St] Status:MEDLINE

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[PMID]: 27983628
[Au] Autor:Chin KY; Gengatharan D; Mohd Nasru FS; Khairussam RA; Ern SL; Aminuddin SA; Ima-Nirwana S
[Ad] Address:Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Malaysia. chinkokyong@ppukm.ukm.edu.my.
[Ti] Title:The Effects of Annatto Tocotrienol on Bone Biomechanical Strength and Bone Calcium Content in an Animal Model of Osteoporosis Due to Testosterone Deficiency.
[So] Source:Nutrients;8(12), 2016 Dec 14.
[Is] ISSN:2072-6643
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Osteoporosis reduces the skeletal strength and increases the risk for fracture. It is an underdiagnosed disease in men. Annatto tocotrienol has been shown to improve bone structural indices and increase expression of bone formation genes in orchidectomized rats. This study aimed to evaluate the effects of annatto tocotrienol on biomechanical strength and calcium content of the bone in orchidectomized rats. Thirty three-month-old male Sprague-Dawley rats were randomly assigned to five groups. The baseline control (BC) group was sacrificed at the onset of the study. The sham-operated group (SHAM) received olive oil (the vehicle of tocotrienol) orally daily and peanut oil (the vehicle of testosterone) intramuscularly weekly. The remaining rats were orchidectomized and treated with three different regimens, i.e., (1) daily oral olive oil plus weekly intramuscular peanut oil injection; (2) daily oral annatto tocotrienol at 60 mg/kg plus weekly intramuscular peanut oil injection; (3) daily oral olive oil plus weekly intramuscular testosterone enanthate injection at 7 mg/kg. Blood, femur and tibia of the rats were harvested at the end of the two-month treatment period for the evaluation of serum total calcium and inorganic phosphate levels, bone biomechanical strength test and bone calcium content. Annatto-tocotrienol treatment improved serum calcium level and tibial calcium content ( < 0.05) but it did not affect femoral biomechanical strength ( > 0.05). In conclusion, annatto-tocotrienol at 60 mg/kg augments bone calcium level by preventing calcium mobilization into the circulation. A longer treatment period is needed for annatto tocotrienol to exert its effects on bone strength.
[Mh] MeSH terms primary: Bone and Bones/drug effects
Calcium/analysis
Carotenoids/pharmacology
Osteoporosis/drug therapy
Plant Extracts/pharmacology
Tocotrienols/pharmacology
[Mh] MeSH terms secundary: Androgens/administration & dosage
Animals
Bixaceae
Bone Density/drug effects
Bone and Bones/chemistry
Calcium/blood
Disease Models, Animal
Femur/drug effects
Male
Orchiectomy
Osteoporosis/etiology
Osteoporosis/physiopathology
Random Allocation
Rats
Rats, Sprague-Dawley
Testosterone/administration & dosage
Testosterone/analogs & derivatives
Testosterone/deficiency
Tibia/drug effects
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Androgens); 0 (Plant Extracts); 0 (Tocotrienols); 36-88-4 (Carotenoids); 3XMK78S47O (Testosterone); 6PQP1V1B6O (annatto); 7Z6522T8N9 (testosterone enanthate); SY7Q814VUP (Calcium)
[Em] Entry month:1704
[Cu] Class update date: 170403
[Lr] Last revision date:170403
[Js] Journal subset:IM
[Da] Date of entry for processing:161216
[St] Status:MEDLINE

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[PMID]: 27708658
[Au] Autor:Rivera-Madrid R; Aguilar-Espinosa M; Cárdenas-Conejo Y; Garza-Caligaris LE
[Ad] Address:Unidad de Bioquimica y Biologia Molecular de Plantas, Centro de Investigación Científica de Yucatán A.C. Mérida, Mexico.
[Ti] Title:Carotenoid Derivates in Achiote ( ) Seeds: Synthesis and Health Promoting Properties.
[So] Source:Front Plant Sci;7:1406, 2016.
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:(family Bixaceae) is a neotropical fast growing perennial tree of great agro-industrial value because its seeds have a high carotenoid content, mainly bixin. It has been used since pre-colonial times as a culinary colorant and spice, and for healing purposes. It is currently used as a natural pigment in the food, in pharmaceutical, and cosmetic industries, and it is commercially known as annatto. Recently, several studies have addressed the biological and medical properties of this natural pigment, both as potential source of new drugs or because its ingestion as a condiment or diet supplement may protect against several diseases. The most documented properties are anti-oxidative; but its anti-cancer, hypoglucemic, antibiotic and anti-inflammatory properties are also being studied. Bixin's pathway elucidation and its regulation mechanisms are critical to improve the produce of this important carotenoid. Even though the bixin pathway has been established, the regulation of the genes involved in bixin production remains largely unknown. Our laboratory recently published transcriptome and we have identified most of its MEP (methyl-D-erythritol 4-phosphate) and carotenoid pathway genes. Annatto is a potential source of new drugs and can be a valuable nutraceutical supplement. However, its nutritional and healing properties require further study.
[Pt] Publication type:REVIEW; JOURNAL ARTICLE
[Em] Entry month:1610
[Cu] Class update date: 161102
[Lr] Last revision date:161102
[St] Status:In-Data-Review

  5 / 171 MEDLINE  
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[PMID]: 27256894
[Au] Autor:Raju D; Mehta UJ; Beedu SR
[Ad] Address:Department of Biochemistry, University College of Science, Osmania University, Hyderabad 500 007, Telangana, India.
[Ti] Title:Biogenic green synthesis of monodispersed gum kondagogu (Cochlospermum gossypium) iron nanocomposite material and its application in germination and growth of mung bean (Vigna radiata) as a plant model.
[So] Source:IET Nanobiotechnol;10(3):141-6, 2016 Jun.
[Is] ISSN:1751-8741
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:An eco-friendly green and one-pot synthesis of highly monodispersed iron (Fe) nanoparticles (NPs) by using a natural biopolymer, gum kondagogu (GK) as reducing and capping agent is proposed. The NPs synthesised were characterised by ultra-violet-visible spectroscopy, transmission electron microscopy, scanning electron microscopy and X-ray diffraction. As the concentration of gum and time increases, the intensity of NPs formation increased. The NPs were highly monodispersed with uniform circular shapes of 2-6 nm in size. The formed NPs were crystalline in nature which was confirmed by diffraction analysis. The conversion ratio of Fe ionic form to NPs was 21% which was quantified by inductively coupled plasma mass spectroscopy (ICP-MS). Fe is essential for plant growth and development. A study was conducted to examine the effect of these NPs on the growth of mung bean (Vigna radiata). The radical length and biomass was increased in seeds exposed to Fe NPs than the ions. The uptake of Fe NPs by the sprouts was also quantified by ICP-MS, in which Fe was more in mung bean seeds exposed to NPs. The α-amylase activity was increased in the seeds exposed to NPs. The observed increase in the biomass by Fe NPs and seed germination may facilitate its application in the agriculture as an important cost-effective method for plant growth.
[Mh] MeSH terms primary: Bixaceae/chemistry
Iron/chemistry
Nanocomposites/chemistry
Plant Gums/chemistry
Plant Gums/pharmacology
[Mh] MeSH terms secundary: Fabaceae/drug effects
Germination/drug effects
Green Chemistry Technology
Iron/pharmacology
Models, Biological
Plant Proteins/analysis
Plant Proteins/metabolism
alpha-Amylases/analysis
alpha-Amylases/metabolism
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Plant Gums); 0 (Plant Proteins); E1UOL152H7 (Iron); EC 3.2.1.1 (alpha-Amylases)
[Em] Entry month:1609
[Cu] Class update date: 161021
[Lr] Last revision date:161021
[Js] Journal subset:IM
[Da] Date of entry for processing:160603
[St] Status:MEDLINE
[do] DOI:10.1049/iet-nbt.2015.0112

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[PMID]: 27106285
[Au] Autor:Behrens CJ; Zelena K; Berger RG
[Ad] Address:Gottfried Wilhelm Leibniz Universität Hannover, Institut für Lebensmittelchemie, Callinstraße 5, 30167, Hannover, Germany. christoph.behrens@lci.uni-hannover.de.
[Ti] Title:Comparative Cold Shock Expression and Characterization of Fungal Dye-Decolorizing Peroxidases.
[So] Source:Appl Biochem Biotechnol;179(8):1404-17, 2016 Aug.
[Is] ISSN:1559-0291
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Dye-decolorizing peroxidases (DyPs) from Auricularia auricula-judae, Bjerkandera adusta, Pleurotus ostreatus and Marasmius scorodonius (Basidiomycota) were expressed in Escherichia coli using the cold shock-inducible expression system pCOLD I DNA. Functional expression was achieved without the addition of hemin or the co-expression of any chaperones. The presence or absence of the native signal sequence had a strong impact on the success of the expression, but the effect was not consistent for the different DyPs. While BaDyP and AajDyP were stable at 50 °C, the more thermolabile MsP2 and PoDyp, upon catalytic intervention, lend themselves to more rapid thermal inactivation. The bleaching of norbixin (E 160b) using MsP2 was most efficient at pH 4.0, while BaDyP and AajDypP worked best in the weakly acidic to neutral range, indicating a choice of DyPs for a broad field of applications in different food matrices.
[Mh] MeSH terms primary: Cold Temperature
Coloring Agents/metabolism
Fungi/enzymology
Peroxidases/metabolism
[Mh] MeSH terms secundary: Amino Acid Sequence
Benzothiazoles/metabolism
Bixaceae/metabolism
Carotenoids/metabolism
Color
Fungal Proteins/chemistry
Fungal Proteins/genetics
Fungal Proteins/metabolism
Fungi/genetics
Genes, Fungal
Peroxidases/chemistry
Peroxidases/genetics
Plant Extracts/metabolism
Pleurotus/enzymology
Pleurotus/genetics
Recombinant Proteins/metabolism
Sequence Alignment
Substrate Specificity
Sulfonic Acids/metabolism
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Name of substance:0 (Benzothiazoles); 0 (Coloring Agents); 0 (Fungal Proteins); 0 (Plant Extracts); 0 (Recombinant Proteins); 0 (Sulfonic Acids); 28752-68-3 (2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid); 36-88-4 (Carotenoids); 6PQP1V1B6O (annatto); EC 1.11.1.- (Peroxidases)
[Em] Entry month:1701
[Cu] Class update date: 170113
[Lr] Last revision date:170113
[Js] Journal subset:IM
[Da] Date of entry for processing:160810
[St] Status:MEDLINE
[do] DOI:10.1007/s12010-016-2073-0

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[PMID]: 27083339
[Au] Autor:Bernela M; Ahuja M; Thakur R
[Ad] Address:Department of Bio & NanoTechnology, Guru Jambheshwar University of Science & Technology, Hisar, Haryana 125001, India.
[Ti] Title:Enhancement of anti-inflammatory activity of bromelain by its encapsulation in katira gum nanoparticles.
[So] Source:Carbohydr Polym;143:18-24, 2016 Jun 05.
[Is] ISSN:1879-1344
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Bromelain-loaded katira gum nanoparticles were synthesized using 3 level optimization process and desirability approach. Nanoparticles of the optimized batch were characterized using particle size analysis, zeta potential, transmission electron microscopy and Fourier-transform infrared spectroscopy. Investigation of their in vivo anti-inflammatory activity by employing carrageenan induced rat-paw oedema method showed that encapsulation of bromelain in katira gum nanoparticles substantially enhanced its anti-inflammatory potential. This may be attributed to enhanced absorption owing to reduced particle size or to protection of bromelain from acid proteases.
[Mh] MeSH terms primary: Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
Bixaceae/chemistry
Bromelains/therapeutic use
Plant Gums/chemistry
[Mh] MeSH terms secundary: Animals
Anti-Inflammatory Agents, Non-Steroidal/chemistry
Bromelains/chemistry
Calcium Chloride
Carrageenan
Diclofenac/therapeutic use
Drug Compounding
Edema/chemically induced
Edema/drug therapy
Female
Magnesium Chloride
Male
Nanoparticles
Particle Size
Rats
Rats, Wistar
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Plant Gums); 02F3473H9O (Magnesium Chloride); 144O8QL0L1 (Diclofenac); 9000-07-1 (Carrageenan); 9001-00-7 (Bromelains); EC 3.4.22.32 (stem bromelain); M4I0D6VV5M (Calcium Chloride)
[Em] Entry month:1702
[Cu] Class update date: 170213
[Lr] Last revision date:170213
[Js] Journal subset:IM
[Da] Date of entry for processing:160416
[St] Status:MEDLINE

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[PMID]: 26922728
[Au] Autor:Sankari M; Hemachandran H; Anantharaman A; Babu S; Madrid RR; C GP; Fulzele DP; Siva R
[Ad] Address:School of Bio Sciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India.
[Ti] Title:Identifying a Carotenoid Cleavage Dioxygenase 4a Gene and Its Efficient Agrobacterium-Mediated Genetic Transformation in Bixa orellana L.
[So] Source:Appl Biochem Biotechnol;179(5):697-714, 2016 Jul.
[Is] ISSN:1559-0291
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Carotenoids are metabolized to apocarotenoids through the pathway catalysed by carotenoid cleavage oxygenases (CCOs). The apocarotenoids are economically important as it is known to have therapeutic as well as industrial applications. For instance, bixin from Bixa orellana and crocin from Crocus sativus are commercially used as a food colourant and cosmetics since prehistoric time. In our present study, CCD4a gene has been identified and isolated from leaves of B. orellana for the first time and named as BoCCD4a; phylogenetic analysis was carried out using CLUSTAL W. From sequence analysis, BoCCD4a contains two exons and one intron, which was compared with the selected AtCCD4, RdCCD4, GmCCD4 and CmCCD4a gene. Further, the BoCCD4a gene was cloned into pCAMBIA 1301, transformed into Agrobacterium tumefaciens EHA105 strain and subsequently transferred into hypocotyledons and callus of B. orellana by agro-infection. Selection of stable transformation was screened on the basis of PCR detection by using GUS and hptII specific primer, which was followed by histochemical characterization. The percent transient GUS expression in hypocotyledons and callus was 84.4 and 80 %, respectively. The expression of BoCCD4a gene in B. orellana was confirmed through RT-PCR analysis. From our results, the sequence analysis of BoCCD4a gene of B. orellana was closely related to the CsCCD4 gene of C. sativus, which suggests this gene may have a role in various processes such as fragrance, insect attractant and pollination.
[Mh] MeSH terms primary: Arabidopsis Proteins/genetics
Carotenoids/metabolism
Dioxygenases/genetics
Oxygenases/genetics
Phylogeny
[Mh] MeSH terms secundary: Agrobacterium/genetics
Arabidopsis/enzymology
Arabidopsis/genetics
Arabidopsis Proteins/metabolism
Bixaceae/enzymology
Bixaceae/genetics
Carotenoids/genetics
Crocus/enzymology
Crocus/genetics
Dioxygenases/metabolism
Oxygenases/metabolism
Transformation, Genetic
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Arabidopsis Proteins); 36-88-4 (Carotenoids); 9L7T4VB66G (bixin); EC 1.- (CCD4 protein, Arabidopsis); EC 1.13.- (Oxygenases); EC 1.13.- (carotenoid oxygenase); EC 1.13.11.- (Dioxygenases)
[Em] Entry month:1701
[Cu] Class update date: 170113
[Lr] Last revision date:170113
[Js] Journal subset:IM
[Da] Date of entry for processing:160714
[St] Status:MEDLINE
[do] DOI:10.1007/s12010-016-2025-8

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[PMID]: 26894846
[Au] Autor:Ayodhya D; Veerabhadram G
[Ad] Address:Department of Chemistry, University College of Science, Osmania University, Hyderabad 500007, Telangana State, India.
[Ti] Title:Green synthesis, characterization, photocatalytic, fluorescence and antimicrobial activities of Cochlospermum gossypium capped Ag2S nanoparticles.
[So] Source:J Photochem Photobiol B;157:57-69, 2016 Apr.
[Is] ISSN:1873-2682
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:The study describes a simple and green method for the synthesis of silver sulfide nanoparticles (Ag2S NPs) using gum kondagogu (Cochlospermum gossypium) (GK). The synthesized NPs were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), fluorescence, UV-vis absorption, zeta potential and thermogravimetric analysis (TGA) techniques. The optical properties and quantum confinement effect of the products were confirmed by means of spectroscopic measurements. The morphologies and sizes were characterized by SEM and TEM. The Ag2S NPs were spherical in shape with an effective diameter size of 25 nm. The photocatalytic property of Ag2S NPs was evaluated by the degradation of fluorescein (FL) dye under solar light. The effect of Ag2SNPs on the photocatalytic degradation of FL dye and influence of other parameters such as Ag2S loading, H2O2, temperature and under solar light irradiation was also evaluated. The degradation reaction follows the pseudo-first order kinetics. The apparent reaction rate was used to calculate the apparent activation energy (Ea=13.95 kJ/mol) of the degradation process. The activation thermodynamic parameters (ΔG*, ΔH* and ΔS*) were obtained from variable temperature kinetic studies. The interaction between Ag2S NPs and bovine serum albumin (BSA) was studied by using fluorescence spectroscopic measurements. The synthesized Ag2S NPs were showing good antimicrobial activity.
[Mh] MeSH terms primary: Anti-Infective Agents/pharmacology
Bixaceae/chemistry
Metal Nanoparticles
Silver Compounds/chemistry
Silver Compounds/pharmacology
[Mh] MeSH terms secundary: Catalysis
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Photochemical Processes
Spectrometry, Fluorescence
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Thermogravimetry
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Anti-Infective Agents); 0 (Silver Compounds); 9ZB10YHC1C (silver sulfide)
[Em] Entry month:1612
[Cu] Class update date: 161230
[Lr] Last revision date:161230
[Js] Journal subset:IM
[Da] Date of entry for processing:160309
[St] Status:MEDLINE

  10 / 171 MEDLINE  
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[PMID]: 26876518
[Au] Autor:Prada AL; Bitencourt AP; Amado JR; Cruz RA; Carvalho JC; Fernandes CP
[Ti] Title:Development and Characterization of Cassia grandis and Bixa orellana Nanoformulations.
[So] Source:Curr Top Med Chem;16(18):2057-65, 2016.
[Is] ISSN:1873-4294
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Cassia grandis and Bixa orellana are important plant species with folk use and great potential for phytopharmaceuticals. Nanodispersions are disperse systems of insoluble or immiscible substances in a liquid medium that may be prepared with or without coating polymers. To our knowledge, no studies were carried in order to achieve coating-polymer free nanoformulations using B. orellana extract or any C. grandis-based nanoformulations. Thus, on the present study we aimed to develop C. grandis nanoformulations using three different coating polymers (Eudragit® L 100 55, PEG 4000 and Kollicoat®), while B. orellana nanodispersions were obtained using different surfactants (polysorbate 80, polysorbate 20, polyethylene glycol 400 monooleate, polyethylene glycol 600 monooleate, polyethylene glycol 400 dioleate and polyethylene glycol 600 dioleate) as coating polymer-free nanoformulations. Characterization of nanoformulations was performed by different parameters, including particle size, polydispersity index and zeta-potential. Our results suggested that some optimal nanoformulations were obtained for both plant species. Moreover, possible stable behavior was observed during storage period for C. grandis (30 days) and B. orellana (21 days). On this context, the present study contributes to nanobiotechnology development of phytopharmaceuticals, allowing achievement of novel nano-delivery systems with two important folk medicinal plant extracts and making them potential products for innovative phytopharmaceuticals.
[Mh] MeSH terms primary: Bixaceae/chemistry
Cassia/chemistry
Drug Compounding/methods
Nanoparticles/chemistry
[Mh] MeSH terms secundary: Hydrogen-Ion Concentration
Particle Size
Plant Extracts/chemistry
Plants, Medicinal/chemistry
Surface-Active Agents/chemistry
Temperature
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Plant Extracts); 0 (Surface-Active Agents)
[Em] Entry month:1702
[Cu] Class update date: 170206
[Lr] Last revision date:170206
[Js] Journal subset:IM
[Da] Date of entry for processing:160513
[St] Status:MEDLINE


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