Database : MEDLINE
Search on : Bone and Marrow [Words]
References found : 320279 [refine]
Displaying: 1 .. 10   in format [Detailed]

page 1 of 32028 go to page                         

  1 / 320279 MEDLINE  
              next record last record
select
to print
Photocopy
Full text

[PMID]: 25565310
[Au] Autor:Alexander JJ; Chaves LD; Chang A; Jacob A; Ritchie M; Quigg RJ
[Ad] Address:Division of Nephrology, Department of Medicine, Clinical and Translational Research Center, University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York, USA....
[Ti] Title:CD11b is protective in complement-mediated immune complex glomerulonephritis.
[So] Source:Kidney Int;87(5):930-9, 2015 May.
[Is] ISSN:1523-1755
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:In chronic serum sickness, glomerular immune complexes form, yet C57BL/6 mice do not develop glomerulonephritis unless complement factor H (CfH) is absent, indicating the relevance of complement regulation. Complement receptor 3 (CD11b) and Fcγ receptors on leukocytes, and CfH on platelets, can bind immune complexes. Here we induced immune complex-mediated glomerulonephritis in CfH(-/-) mice chimeric for wild-type, CfH(-/-), CD11b(-/-), or FcRγ(-/-) bone marrow stem cells. Glomerulonephritis was worse in CD11b(-/-) chimeras compared with all others, whereas disease in FcRγ(-/-) and wild-type chimeras was comparable. Disease tracked strongly with humoral immune responses, but not glomerular immune complex deposits. Interstitial inflammation with M1 macrophages strongly correlated with glomerulonephritis scores. CD11b(-/-) chimeras had significantly more M1 macrophages and CD4(+) T cells. The renal dendritic cell populations originating from bone marrow-derived CD11c(+) cells were similar in all experimental groups. CD11b(+) cells bearing colony-stimulating factor 1 receptor were present in kidneys, including CD11b(-/-) chimeras; these cells correlated negatively with glomerulonephritis scores. Thus, experimental immune complex-mediated glomerulonephritis is associated with accumulation of M1 macrophages and CD4(+) T cells in kidneys and functional renal insufficiency. Hence, CD11b on mononuclear cells is instrumental in generating an anti-inflammatory response in the inflamed kidney.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Cu] Class update date: 150509
[Lr] Last revision date:150509
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1038/ki.2014.373

  2 / 320279 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25949087
[Au] Autor:Adam MK; Pitcher JD; Shields CL; Maguire JI
[Ad] Address:Retina Service, Wills Eye Hospital, Philadelphia, PA 19107, USA....
[Ti] Title:Enhanced depth imaging optical coherence tomography of precursor cell leukemic choroidopathy before and after chemotherapy.
[So] Source:Middle East Afr J Ophthalmol;22(2):249-52, 2015 Apr-Jun.
[Is] ISSN:0975-1599
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Serous retinal detachment (SRD) can be the initial manifestation of leukemia. Herein, we explore the retinal and choroidal features on enhanced depth imaging optical coherence tomography (EDI-OCT) of SRD in a patient with undiagnosed leukemia. A 23-year-old male developed blurred visual acuity of 20/200 in the right eye oculus dexter (OD) and 20/200 in the left eye oculus sinister (OS). Funduscopically, he manifested serous macular detachment in both eyes oculi uterque (OU) without hemorrhagic retinal abnormalities. EDI-OCT disclosed macular detachment OU and homogeneous, marked choroidal opacification with thickening to 724 m OD and estimated >600 m OS and with loss of choroidal detail OU. Peripheral blood smears revealed severe thrombocytopenia and normal leukocyte count. Peripheral cytochemisty, immunophenotyping, and bone marrow aspirate confirmed the presence of atypical lymphoblasts, fulfilling criteria for precursor cell leukemia. Following systemic chemotherapy, the visual acuity improved to 20/25 OD and 20/20 OS. On EDI-OCT, the choroidal thickening resolved to 431 um OD and 443 um OS, leaving a normal choroidal appearance. Massive choroidal infiltration with leukemic cells could be the cause of serous macular detachment found in patients with newly diagnosed leukemia.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Cu] Class update date: 150509
[Lr] Last revision date:150509
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.4103/0974-9233.150630

  3 / 320279 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25948944
[Au] Autor:Patel TS; Malvania R; Shah MC; Shah MJ; Gami AG
[Ad] Address:Department of Pathology, MP Shah Cancer Hospital, Gujarat Cancer and Research Institute, Ahmadabad, Gujarat, India....
[Ti] Title:Primary hepatic lymphoma: A case report.
[So] Source:J Cytol;32(1):36-8, 2015 Jan-Mar.
[Is] ISSN:0970-9371
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Primary non-Hodgkin lymphoma of the liver is a very rare malignancy. In this case report, we describe a case of primary hepatic lymphoma (PHL) in a 60-year-old man who presented with lump and pain in the abdomen of 2 months' duration. The patient had altered liver function, normal serum alfa fetoprotein level (AFP), normal hemogram and bone marrow. A computed tomography scan of the abdomen and pelvis showed an ill-defined hypodense mass with specks of calcification involving the liver, suggestive of primary malignant mass of liver. Diagnosis of PHL was established on the cytology smear and confirmed by immunohistochemistry on tissue biopsy. This case demonstrates that PHL should be considered in the differential diagnosis of space-occupying liver lesions in the presence of a normal level of AFP. Fine needle aspiration cytology is a faster and safer diagnostic modality even in such a rare case. The case has many unique features like negative serology for viruses, no type B symptom and normal lactate dehydrogenase level.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1505
[Cu] Class update date: 150509
[Lr] Last revision date:150509
[Da] Date of entry for processing:150507
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/0970-9371.155232

  4 / 320279 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text

[PMID]: 25797907
[Au] Autor:Ullah I; Subbarao RB; Rho GJ
[Ad] Address:*Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, Republic of Korea.
[Ti] Title:Human mesenchymal stem cells - current trends and future prospective.
[So] Source:Biosci Rep;35(2), 2015.
[Is] ISSN:1573-4935
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Stem cells are cells specialized cell, capable of renewing themselves through cell division and can differentiate into multi-lineage cells. These cells are categorized as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and adult stem cells. Mesenchymal stem cells (MSCs) are adult stem cells which can be isolated from human and animal sources. Human MSCs (hMSCs) are the non-haematopoietic, multipotent stem cells with the capacity to differentiate into mesodermal lineage such as osteocytes, adipocytes and chondrocytes as well ectodermal (neurocytes) and endodermal lineages (hepatocytes). MSCs express cell surface markers like cluster of differentiation (CD)29, CD44, CD73, CD90, CD105 and lack the expression of CD14, CD34, CD45 and HLA (human leucocyte antigen)-DR. hMSCs for the first time were reported in the bone marrow and till now they have been isolated from various tissues, including adipose tissue, amniotic fluid, endometrium, dental tissues, umbilical cord and Wharton's jelly which harbours potential MSCs. hMSCs have been cultured long-term in specific media without any severe abnormalities. Furthermore, MSCs have immunomodulatory features, secrete cytokines and immune-receptors which regulate the microenvironment in the host tissue. Multilineage potential, immunomodulation and secretion of anti-inflammatory molecules makes MSCs an effective tool in the treatment of chronic diseases. In the present review, we have highlighted recent research findings in the area of hMSCs sources, expression of cell surface markers, long-term invitro culturing, invitro differentiation potential, immunomodulatory features, its homing capacity, banking and cryopreservation, its application in the treatment of chronic diseases and its use in clinical trials.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1504
[Cu] Class update date: 150509
[Lr] Last revision date:150509
[Js] Journal subset:IM
[St] Status:In-Data-Review

  5 / 320279 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text

[PMID]: 25668818
[Au] Autor:Sabbieti MG; Agas D; Capitani M; Marchetti L; Concetti A; Vullo C; Catone G; Gabai V; Shifrin V; Sherman MY; Shneider A; Venanzi FM
[Ad] Address:School of Biosciences and Veterinary Medicine, University of Camerino, Camerino (Italy)....
[Ti] Title:Plasmid DNA-coding p62 as a bone effective anti-inflammatory/anabolic agent.
[So] Source:Oncotarget;6(6):3590-9, 2015 Feb 28.
[Is] ISSN:1949-2553
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We recently reported that a DNA plasmid coding p62-SQSTM1 acts as an effective anti tumor vaccine against both transplantable mouse tumors and canine spontaneous mammary neoplasms. Here we report the unexpected finding that intramuscular delivery of p62 DNA exerts a powerful anti-osteoporotic activity in a mouse model of inflammatory bone loss (i.e, ovariectomy) by combining bone-sparing and osteo-synthetic effects. Notably, the suppression of osteoporosis by p62DNA was associated with a sharp down-regulation of master inflammatory cytokines, and up-regulation of endogenous p62 protein by bone-marrow stromal cells. The present data provide a solid rational to apply p62 DNA vaccine as a safe, new therapeutic for treatment of inflammatory related bone loss diseases.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1503
[Cu] Class update date: 150509
[Lr] Last revision date:150509
[Js] Journal subset:IM
[St] Status:In-Process

  6 / 320279 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text

[PMID]: 25605011
[Au] Autor:Cerny-Reiterer S; Rabenhorst A; Stefanzl G; Herndlhofer S; Hoermann G; Mllauer L; Baumgartner S; Beham-Schmid C; Sperr WR; Mannhalter C; Sill H; Linkesch W; Arock M; Hartmann K; Valent P
[Ad] Address:Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Austria....
[Ti] Title:Long-term treatment with imatinib results in profound mast cell deficiency in Ph+ chronic myeloid leukemia.
[So] Source:Oncotarget;6(5):3071-84, 2015 Feb 20.
[Is] ISSN:1949-2553
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Although mast cells (MC) play an important role in allergic reactions, their physiologic role remains unknown. In mice, several models of MC-deficiency have been developed. However, no comparable human model is available. We examined the in vitro- and in vivo effects of the KIT-targeting drug imatinib on growth and development of human MC. Imatinib was found to inhibit stem cell factor (SCF)-induced differentiation of MC in long-term suspension cultures (IC50: 0.01 M). Correspondingly, long-term treatment of chronic myeloid leukemia (CML) patients with imatinib (400 mg/day) resulted in a marked decrease in MC. In patients with continuous complete molecular response during therapy, bone marrow MC decreased to less than 5% of pre-treatment values, and also serum tryptase concentrations decreased significantly (pre-treatment: 32.0 11.1 ng/ml; post-therapy: 3.4 1.8, p<0.01). Other myeloid lineages, known to develop independently of KIT, were not affected by imatinib-therapy. Imatinib also produced a substantial decrease in MC-development in mice. However, no clinical syndrome attributable to drug-induced MC-deficiency was recorded in our CML patients. Together, imatinib suppresses MC production in vitro and in vivo. However, drug-induced MC depletion is not accompanied by adverse clinical events, suggesting that MC are less relevant to homeostasis in healthy tissues than we assumed so far.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1503
[Cu] Class update date: 150509
[Lr] Last revision date:150509
[Js] Journal subset:IM
[St] Status:In-Process

  7 / 320279 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text

[PMID]: 25474039
[Au] Autor:Raffaghello L; Vacca A; Pistoia V; Ribatti D
[Ad] Address:Laboratorio di Oncologia, Istituto G. Gaslini, Genova, Italy....
[Ti] Title:Cancer associated fibroblasts in hematological malignancies.
[So] Source:Oncotarget;6(5):2589-603, 2015 Feb 20.
[Is] ISSN:1949-2553
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Tumor microenvironment plays an important role in cancer initiation and progression. In hematological malignancies, the bone marrow represents the paradigmatic anatomical site in which tumor microenvironment expresses its morphofunctional features. Among the cells participating in the composition of this microenvironment, cancer associated fibrobasts (CAFs) have received less attention in hematopoietic tumors compared to solid cancers. In this review article, we discuss the involvement of CAFs in progression of hematological malignancies and the potential targeting of CAFs in a therapeutic perspective.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1503
[Cu] Class update date: 150509
[Lr] Last revision date:150509
[Js] Journal subset:IM
[St] Status:In-Process

  8 / 320279 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25621495
[Au] Autor:Huang Y; Clarke F; Karimi M; Roy NH; Williamson EK; Okumura M; Mochizuki K; Chen EJ; Park TJ; Debes GF; Zhang Y; Curran T; Kambayashi T; Burkhardt JK
[Ti] Title:CRK proteins selectively regulate T cell migration into inflamed tissues.
[So] Source:J Clin Invest;125(3):1019-32, 2015 Mar 2.
[Is] ISSN:1558-8238
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Effector T cell migration into inflamed sites greatly exacerbates tissue destruction and disease severity in inflammatory diseases, including graft-versus-host disease (GVHD). T cell migration into such sites depends heavily on regulated adhesion and migration, but the signaling pathways that coordinate these functions downstream of chemokine receptors are largely unknown. Using conditional knockout mice, we found that T cells lacking the adaptor proteins CRK and CRK-like (CRKL) exhibit reduced integrin-dependent adhesion, chemotaxis, and diapedesis. Moreover, these two closely related proteins exhibited substantial functional redundancy, as ectopic expression of either protein rescued defects in T cells lacking both CRK and CRKL. We determined that CRK proteins coordinate with the RAP guanine nucleotide exchange factor C3G and the adhesion docking molecule CASL to activate the integrin regulatory GTPase RAP1. CRK proteins were required for effector T cell trafficking into sites of inflammation, but not for migration to lymphoid organs. In a murine bone marrow transplantation model, the differential migration of CRK/CRKL-deficient T cells resulted in efficient graft-versus-leukemia responses with minimal GVHD. Together, the results from our studies show that CRK family proteins selectively regulate T cell adhesion and migration at effector sites and suggest that these proteins have potential as therapeutic targets for preventing GVHD.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1503
[Cu] Class update date: 150509
[Lr] Last revision date:150509
[Js] Journal subset:AIM; IM
[St] Status:In-Process

  9 / 320279 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text

[PMID]: 25594182
[Au] Autor:Tamplin OJ; Durand EM; Carr LA; Childs SJ; Hagedorn EJ; Li P; Yzaguirre AD; Speck NA; Zon LI
[Ad] Address:Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA....
[Ti] Title:Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche.
[So] Source:Cell;160(1-2):241-52, 2015 Jan 15.
[Is] ISSN:1097-4172
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Hematopoietic stem and progenitor cells (HSPCs) can reconstitute and sustain the entire blood system. We generated a highly specific transgenic reporter of HSPCs in zebrafish. This allowed us to perform high-resolution live imaging on endogenous HSPCs not currently possible in mammalian bone marrow. Using this system, we have uncovered distinct interactions between single HSPCs and their niche. When an HSPC arrives in the perivascular niche, a group of endothelial cells remodel to form a surrounding pocket. This structure appears conserved in mouse fetal liver. Correlative light and electron microscopy revealed that endothelial cells surround a single HSPC attached to a single mesenchymal stromal cell. Live imaging showed that mesenchymal stromal cells anchor HSPCs and orient their divisions. A chemical genetic screen found that the compound lycorine promotes HSPC-niche interactions during development and ultimately expands the stem cell pool into adulthood. Our studies provide evidence for dynamic niche interactions upon stem cell colonization. PAPERFLICK:
[Mh] MeSH terms primary: Endothelium/physiology
Hematopoietic Stem Cells/cytology
Zebrafish/embryology
[Mh] MeSH terms secundary: Animals
Animals, Genetically Modified
Cell Division
Core Binding Factor alpha Subunits/genetics
Core Binding Factor alpha Subunits/metabolism
Embryo, Nonmammalian/blood supply
Embryo, Nonmammalian/physiology
Endothelium/cytology
Hematopoietic Stem Cells/physiology
Mesoderm/cytology
Mesoderm/metabolism
Mice
Mice, Inbred C57BL
Stem Cell Niche
Stromal Cells/cytology
Stromal Cells/metabolism
Zebrafish/physiology
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Name of substance:0 (Core Binding Factor alpha Subunits)
[Em] Entry month:1504
[Cu] Class update date: 150509
[Lr] Last revision date:150509
[Js] Journal subset:IM
[Da] Date of entry for processing:150117
[St] Status:MEDLINE

  10 / 320279 MEDLINE  
              first record previous record
select
to print
Photocopy
Full text

[PMID]: 25398607
[Au] Autor:Barnes MA; McMullen MR; Roychowdhury S; Madhun NZ; Niese K; Olman MA; Stavitsky AB; Bucala R; Nagy LE
[Ad] Address:Departments of *Molecular Medicine and Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA; Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; and Departments of Pathobiology and Gastroenterology and Hepatology, Center for L...
[Ti] Title:Macrophage migration inhibitory factor is required for recruitment of scar-associated macrophages during liver fibrosis.
[So] Source:J Leukoc Biol;97(1):161-9, 2015 Jan.
[Is] ISSN:1938-3673
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Recruitment of peripheral monocytes to the liver is a key contributor to the response to injury. MIF can act as a chemokine and cytokine, regulating innate immune responses in many tissues and cell types. We hypothesized that MIF contributes to the progression of CCl4-induced hepatic fibrosis by regulating recruitment of SAM. SAMs dynamically regulate HSC activation and ECM degradation. To gain insight into the role of MIF in progression of liver fibrosis, we investigated markers of fibrosis and immune responses after chronic CCl4 administration to female C57BL/6 and MIF(-/-) mice. Chronic CCl4 exposure increased activation of HSC in WT mice, indicated by increased expression of αSMA mRNA and protein, as well as mRNA for collagen 1α1; these responses were blunted in female MIF(-/-) mice. Despite lower activation of HSC in MIF(-/-) mice, accumulation of ECM was similar in WT and MIF(-/-)mice, suggesting a decreased rate of ECM degradation. Recruitment of SAMs was lower in MIF(-/-) mice compared with WT mice, both in their initial inflammatory phenotype, as well as in the later phase as proresolution macrophages. The decreased presence of resolution macrophages was associated with lower expression of MMP13 in MIF(-/-) mice. Taken together, these data indicate that MIF-dependent recruitment of SAMs contributes to degradation of ECM via MMP13, highlighting the importance of appropriate recruitment and phenotypic profile of macrophages in the resolution of fibrosis.
[Mh] MeSH terms primary: Intramolecular Oxidoreductases/metabolism
Liver Cirrhosis/immunology
Macrophage Migration-Inhibitory Factors/metabolism
Macrophages/immunology
[Mh] MeSH terms secundary: Animals
Chemotaxis, Leukocyte
Cicatrix
Disease Models, Animal
Extracellular Matrix/pathology
Female
Flow Cytometry
Immunoblotting
Immunohistochemistry
Liver Cirrhosis/pathology
Male
Matrix Metalloproteinase 13/immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
Reverse Transcriptase Polymerase Chain Reaction
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Name of substance:0 (Macrophage Migration-Inhibitory Factors); EC 3.4.24.- (Matrix Metalloproteinase 13); EC 3.4.24.- (Mmp13 protein, mouse); EC 5.3.- (Intramolecular Oxidoreductases); EC 5.3.2.1 (Mif protein, mouse)
[Em] Entry month:1503
[Cu] Class update date: 150509
[Lr] Last revision date:150509
[Js] Journal subset:IM
[Da] Date of entry for processing:150106
[St] Status:MEDLINE
[do] DOI:10.1189/jlb.3A0614-280R


page 1 of 32028 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information