Database : MEDLINE
Search on : Bone and Marrow [Words]
References found : 339590 [refine]
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[PMID]: 27191729
[Au] Autor:Hansen CN; Norden DM; Faw TD; Deibert R; Wohleb ES; Sheridan JF; Godbout JP; Basso DM
[Ad] Address:Center for Brain and Spinal Cord Repair, The Ohio State University, Columbus, OH 43210, USA; School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH 43210, USA; Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA....
[Ti] Title:Lumbar Myeloid Cell Trafficking into Locomotor Networks after Thoracic Spinal Cord Injury.
[So] Source:Exp Neurol;282:86-98, 2016 Aug.
[Is] ISSN:1090-2430
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Spinal cord injury (SCI) promotes inflammation along the neuroaxis that jeopardizes plasticity, intrinsic repair and recovery. While inflammation at the injury site is well-established, less is known within remote spinal networks. The presence of bone marrow-derived immune (myeloid) cells in these areas may further impede functional recovery. Previously, high levels of the gelatinase, matrix metalloproteinase-9 (MMP-9) occurred within the lumbar enlargement after thoracic SCI and impeded activity-dependent recovery. Since SCI-induced MMP-9 potentially increases vascular permeability, myeloid cell infiltration may drive inflammatory toxicity in locomotor networks. Therefore, we examined neurovascular reactivity and myeloid cell infiltration in the lumbar cord after thoracic SCI. We show evidence of region-specific recruitment of myeloid cells into the lumbar but not cervical region. Myeloid infiltration occurred with concomitant increases in chemoattractants (CCL2) and cell adhesion molecules (ICAM-1) around lumbar vasculature 24h and 7days post injury. Bone marrow GFP chimeric mice established robust infiltration of bone marrow-derived myeloid cells into the lumbar gray matter 24h after SCI. This cell infiltration occurred when the blood-spinal cord barrier was intact, suggesting active recruitment across the endothelium. Myeloid cells persisted as ramified macrophages at 7days post injury in parallel with increased inhibitory GAD67 labeling. Importantly, macrophage infiltration required MMP-9.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1606
[Cu] Class update date: 160702
[Lr] Last revision date:160702
[Js] Journal subset:IM
[St] Status:In-Data-Review

  2 / 339590 MEDLINE  
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[PMID]: 26906203
[Au] Autor:Agrba VZ; Porkhanov VA; Karal-Ogly DD; Leontyuk AV; Kovalenko AL; Sholin IY; Gvozdik TE; Ignatova IE; Agumava AA; Chuguev YP; Gvaramiya IA; Lapin BA
[Ad] Address:Research Institute of Medical Primatology, Sochi, Russia. agrba_vz@mail.ru....
[Ti] Title:Transplantation of Simian Mesenchymal Stem Cells to Baboons with Experimentally Induced Myocardial Infarction.
[So] Source:Bull Exp Biol Med;160(4):589-91, 2016 Feb.
[Is] ISSN:1573-8221
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Culture of mesenchymal stem cells isolated from the bone marrow of primates by their characteristics met the requirements of stem cells. It was shown that transplantation of allogeneic mesenchymal stem cells (2 million cells per 1 kg body weight) immediately after ligation of the left anterior descending coronary artery between the middle and upper thirds led to neovascularization and capillarization of the ischemic myocardium.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1603
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1007/s10517-016-3223-7

  3 / 339590 MEDLINE  
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[PMID]: 26906195
[Au] Autor:Dygai AM; Skurikhin EG; Pershina OV; Ermakova NN; Krupin VA; Ermolaeva LA; Stakheeva MN; Choinzonov EL; Goldberg VE; Reikhart DV; Ellinidi VN; Kravtsov VY
[Ad] Address:E. D. Goldberg Research Institute of Pharmacology and Regene rative Medicine, Tomsk, Russia....
[Ti] Title:Role of Hematopoietic Stem Cells in Inflammation of the Pancreas during Diabetes Mellitus.
[So] Source:Bull Exp Biol Med;160(4):474-9, 2016 Feb.
[Is] ISSN:1573-8221
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The model of streptozotocin-induced diabetes mellitus in C57Bl/6 mice was employed to study the role of precursors of insulin-producing ß-cells, hematopoietic stem cells, and progenitor hematopoietic cells in inflammation. In addition to provoking hyperglycemia, streptozotocin elevated serum levels of IL-1ß and hyaluronic acid, induced edema in the pancreatic insular tissue and its infiltration by inflammatory cells (neutrophils, lymphocytes, and macrophages) and fibroblasts. Inflammation in pancreatic islets was accompanied by necrotic processes and decreasing counts of multipotent progenitor ß-cells (CD45(-), TER119(-), c-kit-1(-), and Flk-1(-)), oligopotent progenitor ß-cells (CD45(-), TER119(-), CD133(+), and CD49f(low)), and insulinproducing ß-cells (Pdx1(+)). Pancreatic infl ammation was preceded by elevation of the number of short-term hematopoietic stem cells (Lin-Sca-1(+)c-kit(+)CD34(+)) relative to long-term cells (Lin(-)Sca-1(+)c-kit(+)CD34(-)) in the bone marrow as well as recruitment of hematopoietic stem and progenitor cells into circulation. Transplantation of bone marrow hematopoietic stem and progenitor cells from diabetic C57Bl/6 donor mice to recipient CBA mice with 5-fluorouracilinduced leukopenia accelerated regeneration of granulocytopoiesis in recipient mice.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1603
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1007/s10517-016-3200-1

  4 / 339590 MEDLINE  
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[PMID]: 26902361
[Au] Autor:Shevela EY; Starostina NM; Pal'tsev AI; Shipunov MV; Zheltova OI; Meledina IV; Khvan LA; Leplina OY; Ostanin AA; Chernykh ER; Kozlov VA
[Ad] Address:Research Institute of Clinical Immunology, Novosibirsk, Russia. ct_lab@mail.ru....
[Ti] Title:Efficiency of Cell Therapy in Liver Cirrhosis.
[So] Source:Bull Exp Biol Med;160(4):542-7, 2016 Feb.
[Is] ISSN:1573-8221
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We studied safety and clinical efficacy of transplantation of autologous bone marrow cell in complex therapy of 158 patients with chronic hepatitis and cirrhosis of the liver. The efficiency of cell therapy was assessed in 12 months after single injection of the cells. The positive response (alleviation of liver cirrhosis or stabilization of the pathological process) was observed in 70% cases. The efficacy of therapy correlated with the severity and etiology of the disease and was maximum in patients with Child-Pugh class A (in 82.5% cases) and class B liver cirrhosis (in 79% cases); in patients with class C liver cirrhosis, the positive response was achieved in 42.5% cases. In 39 patients, ultrasonic examination performed in 3 years after transplantation revealed no focal lesions or ectopic ossification foci.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1603
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1007/s10517-016-3215-7

  5 / 339590 MEDLINE  
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[PMID]: 26902356
[Au] Autor:Skurikhin EG; Ermakova NN; Pershina OV; Krupin VA; Pakhomova AV; Dygai AM
[Ad] Address:E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. eskurihin@inbox.ru....
[Ti] Title:Response of Hematopoietic Stem and Progenitor Cells to Reserpine in C57Bl/6 Mice.
[So] Source:Bull Exp Biol Med;160(4):439-43, 2016 Feb.
[Is] ISSN:1573-8221
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We studied the response of hematopoietic stem cells and progenitor cells to sympatholytic reserpine in intact C57Bl/6 mice and in animals with cyclophosphamide-induced leukopenia. The count of long-term hematopoietic stem cells (Lin(-)Sca-1(+)c-kit(+)CD34(-)) in the bone marrow of healthy mice increased in 7 min after reserpine injection and remained elevated in 2 h in parallel with elevated content of short-term stem (Lin(-)Sca-1(+)c-kit(+)CD34(+)) and progenitor (Lin(-)Sca-1(+)c-kit(+)) cells. Reserpine produced no effect on recruitment of hematopoietic stem and progenitor cells into the peripheral blood, but increased the serum level of granulocyte CSF and increased the count of metamyelocytes and neutrophilic granulocytes in the blood (in 2 h postinjection). Transplantation of bone marrow hematopoietic stem and progenitor cells from reserpine-treated donor C57Bl/6 mice to recipient CBA mice with 5-fluorouracil-induced leukopenia accelerated regeneration of the granulocytic lineage cells in leukemic mice. In cyclophosphamide-treated C57Bl/6 mice, reserpine reduced the level of short-term hematopoietic stem cells and increased the count of progenitor hematopoietic cells in the bone marrow in parallel with recruitment of the progenitors into the peripheral blood.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1603
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1007/s10517-016-3191-y

  6 / 339590 MEDLINE  
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[PMID]: 26902349
[Au] Autor:Zhdanov VV; Udut EV; Sotnikova LS; Burmina YV; Miroshnichenko LA; Simanina EV; Polyakova TY; Zyuz'kov GN; Chaikovskii AV; Stavrova LA; Fedorova EP; Dygai AM
[Ad] Address:E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia....
[Ti] Title:Pathogenetic Evaluation of Dysfunction in the Erythron System of Experimental Animals during Modeling of Iron Deficiency Anemia in the Gestation Period.
[So] Source:Bull Exp Biol Med;160(4):417-20, 2016 Feb.
[Is] ISSN:1573-8221
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:We studied the dynamics of erythropoiesis in CBA mice during gestation against the background of treatment with iron-binding drug. The mechanisms of suppression of the bone marrow erythroid stem were evaluated. Administration of deferoxamine in a dose of 1 g/kg induced hypoplasia of the erythroid hemopoietic lineage. Suppression of bone marrow erythropoiesis manifested in a decrease of hemoglobin concentration and counts of reticulocytes, erythrocytes, and erythrokaryocytes. These changes were accompanied by a decrease in functional activity of erythropoietic precursors and secretion of erythropoietically active humoral factors by bone marrow myelokaryocytes. These data indicate that deferoxamine can be used for modeling of iron defi ciency anemia in pregnancy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1603
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1007/s10517-016-3185-9

  7 / 339590 MEDLINE  
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[PMID]: 26899841
[Au] Autor:Maiborodin IV; Morozov VV; Matveeva VA; Chastikin GA; Moshak SV; Onoprienko NV; Seryapina YV; Anikeev AA
[Ad] Address:Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. imai@mail.ru....
[Ti] Title:Possibility of Using Mesenchymal Stromal Cells to Restore Lymph Flow in Experimental Phlebothrombosis.
[So] Source:Bull Exp Biol Med;160(4):565-70, 2016 Feb.
[Is] ISSN:1573-8221
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The possibility of formation of lymphatic vessels after introduction of autologous bone marrow-derived multipotent mesenchymal stromal cells transfected with GFP gene into thrombosed femoral vein was studied by fluorescent microscopy. Vascular thrombosis caused by ligation of the great vein with subsequent injection of thrombin solution was accompanied by blockade of regional lymph flow. The cells injected into thrombosed vein directly participate in the formation of new lymphatic vessels in the paravasal tissue surrounding the vein, its tissue region, and around regional lymph nodes. This is seen from bright specific fluorescence of individual cells in the walls of lymphatic vessels and all vascular layers and valves in UV light.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1603
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1007/s10517-016-3219-3

  8 / 339590 MEDLINE  
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[PMID]: 26936510
[Au] Autor:Sawada Y; Ishii S; Koga Y; Tomizawa T; Matsui A; Tomaru T; Ozawa A; Shibusawa N; Satoh T; Shimizu H; Hirato J; Yamada M
[Ad] Address:Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine.
[Ti] Title:Reversible Hypopituitarism Associated with Intravascular Large B-Cell Lymphoma: Case Report of Successful Immunochemotherapy.
[So] Source:Tohoku J Exp Med;238(3):197-203, 2016.
[Is] ISSN:1349-3329
[Cp] Country of publication:Japan
[La] Language:eng
[Ab] Abstract:Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of diffuse large B-cell lymphoma. There have been only a limited number of reports regarding pituitary dysfunction associated with IVLBCL. We present a 71-year-old woman with hypopituitarism without any hypothalamic/pituitary abnormalities as assessed by magnetic resonance imaging. She presented with edema, abducens palsy, and elevated levels of lactate dehydrogenase and soluble interleukin-2 receptor. Provocative testing showed that the peaks of luteinizing hormone, follicle-stimulating hormone, thyroid-stimulating hormone and adrenocorticotropic hormone were evoked to normal levels by simultaneous administration of luteinizing hormone-releasing hormone, thyrotropin-releasing hormone and corticotropin-releasing hormone, but the responses of these four pituitary hormones showed a delayed pattern. She was diagnosed with IVLBCL with cerebrospinal invasion by pathological findings of the bone marrow, skin, and cerebrospinal fluid. She achieved hematological remission after immunochemotherapy. Pituitary function was also restored without hormonal replacement, and the improvement of the pituitary function was confirmed by dynamic testing. We reviewed the literature with respect to hypopituitarism associated with IVLBCL. There were less than 20 case reports and most of the patients died. Endocrinological course was described in only two cases, and both of them required hormonal supplementation. To our knowledge, this is the first case of hypopituitarism induced by IVLBCL that was successfully managed by immunochemotherapy alone. This case suggests that early diagnosis and treatment of IVLBCL might improve anterior pituitary function and enable patients to avoid hormone replacement therapy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1603
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1620/tjem.238.197

  9 / 339590 MEDLINE  
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[PMID]: 26896884
[Au] Autor:Almeida-Silva F; Damasceno LS; Serna MJ; Valero C; Quintella LP; Almeida-Paes R; Muniz Mde M; Zancope-Oliveira RM
[Ad] Address:Laboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas (INI), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil....
[Ti] Title:Multiple opportunistic fungal infections in an individual with severe HIV disease: A case report.
[So] Source:Rev Iberoam Micol;33(2):118-21, 2016 Apr-Jun.
[Is] ISSN:2173-9188
[Cp] Country of publication:Spain
[La] Language:eng
[Ab] Abstract:BACKGROUND: Fungal infections have been commonly diagnosed in individuals with advanced HIV disease. Cryptococcosis, pneumocystosis, and histoplasmosis are the most frequent systemic mycoses in people suffering from HIV/AIDS. CASE REPORT: We report a case of multiple fungal infections in an advanced AIDS-patient. A 33-year-old HIV-positive man from Brazil was hospitalized due to diarrhea, dyspnea, emaciation, hypoxemia, extensive oral thrush, and a CD4+ T lymphocyte count of 20cells/mm(3). Honeycombed-structures consistent with Pneumocystis jirovecii were observed by direct immunofluorescence in induced sputum. Cryptococcus neoformans was recovered from respiratory secretion and cerebrospinal fluid cultures. Histopathology of the bone marrow also revealed the presence of Histoplasma capsulatum. Molecular assays were performed in a sputum sample. Nested-PCR confirmed the presence of P. jirovecii and H. capsulatum; qPCR multiplex was positive for C. neoformans and H. capsulatum. With the treatment of antifungal drugs the patient progressed satisfactorily. CONCLUSIONS: The diagnosis of several systemic mycoses demonstrates the vulnerability of advanced AIDS-patients. Thus, the detection of AIDS cases in the early stages of infection is necessary for a prompt and adequate introduction of HAART therapy, and the use of prophylaxis to control opportunistic infections.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1607
[Js] Journal subset:IM
[St] Status:In-Data-Review

  10 / 339590 MEDLINE  
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[PMID]: 27207617
[Au] Autor:Cooper ST; Sell SS; Fahrenkrog M; Wilkinson K; Howard DR; Bergen H; Cruz E; Cash SE; Andrews MT; Hampton M
[Ad] Address:Biology Department, University of Wisconsin-La Crosse, La Crosse, Wisconsin; scooper@uwlax.edu....
[Ti] Title:Effects of hibernation on bone marrow transcriptome in thirteen-lined ground squirrels.
[So] Source:Physiol Genomics;48(7):513-25, 2016 Jul 1.
[Is] ISSN:1531-2267
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Mammalian hibernators adapt to prolonged periods of immobility, hypometabolism, hypothermia, and oxidative stress, each capable of reducing bone marrow activity. In this study bone marrow transcriptomes were compared among thirteen-lined ground squirrels collected in July, winter torpor, and winter interbout arousal (IBA). The results were consistent with a suppression of acquired immune responses, and a shift to innate immune responses during hibernation through higher complement expression. Consistent with the increase in adipocytes found in bone marrow of hibernators, expression of genes associated with white adipose tissue are higher during hibernation. Genes that should strengthen the bone by increasing extracellular matrix were higher during hibernation, especially the collagen genes. Finally, expression of heat shock proteins were lower, and cold-response genes were higher, during hibernation. No differential expression of hematopoietic genes involved in erythrocyte or megakaryocyte production was observed. This global view of the changes in the bone marrow transcriptome over both short term (torpor vs. IBA) and long term (torpor vs. July) hypothermia can explain several observations made about circulating blood cells and the structure and strength of the bone during hibernation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1607
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1152/physiolgenomics.00120.2015


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