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[PMID]: 29257039
[Au] Autor:Tran L; Antic T; Lastra RR
[Ad] Address:Department of Pathology, The University of Chicago Medical Center, Chicago, Illinois.
[Ti] Title:Incidental Gynecologic Tract Neoplasms in Women Undergoing Anterior Pelvic Exenteration for Urothelial Carcinoma.
[So] Source:Int J Gynecol Pathol;, 2017 Dec 18.
[Is] ISSN:1538-7151
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Urothelial carcinoma (UC) invasive into the muscularis propria or tumors unresponsive to treatment are indications for cystectomy. In females, with the goal of achieving complete cancer eradication and for concerns of UC extension into the adjacent pelvic organs, this may also warrant resection of the gynecologic organs. This study is aimed to assess the prevalence of unanticipated gynecologic neoplasms in anterior pelvic exenteration specimens. A retrospective review of pathology reports to identify women undergoing anterior pelvic exenteration for UC was performed (N=221), and incidentally discovered gynecologic tract neoplasms were recorded. Concomitant malignant or premalignant lesions of the gynecologic tract were identified in 8 patients (3.6%). These included endometrial adenocarcinoma [endometrioid type, International Federation of Gynecology and Obstetrics grade 1 (n=2, 0.9%)], cervical high-grade squamous intraepithelial lesion (n=2, 0.9%), Sertoli-Leydig cell tumor of intermediate differentiation (n=1, 0.5%), endometrioid adenocarcinoma of the ovary (n=1, 0.5%), and high-grade serous carcinoma of the ovary (n=1, 0.5%) and fallopian tube (n=1, 0.5%). Benign uterine neoplasms included leiomyomas (n=81, 37%), adenomyoma (n=3, 1.4%), and adenomatoid tumors (n=2, 0.9%). Benign ovarian neoplasms included serous cystadenoma (n=7, 3%), serous cystadenofibroma (n=4, 2%), benign Brenner tumor (n=5, 2.3%), mature teratoma (n=4, 2%), stromal luteoma (n=2, 0.9%), mucinous cystadenoma (n=1, 0.5%), thecoma (n=1, 0.5%), and endometrioid cystadenoma (n=1, 0.5%). Involvement of the gynecologic tract by UC was identified in 11 patients (5%). Spread of UC to the reproductive organs is rare in anterior pelvic exenteration specimens. Coexisting neoplasms of the gynecologic tract are occasionally identified, therefore careful evaluation of these organs is necessary.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171219
[Lr] Last revision date:171219
[St] Status:Publisher
[do] DOI:10.1097/PGP.0000000000000478

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[PMID]: 29187928
[Au] Autor:Ajani MA; Salami A; Awolude OA; Oluwasola AO
[Ad] Address:Department of Histopathology, Babcock University, Ilishan-Remo, Ogun state, Nigeria.
[Ti] Title:Hormone-receptor expression status of epithelial ovarian cancer in Ibadan, South-western Nigeria.
[So] Source:Pan Afr Med J;27:259, 2017.
[Is] ISSN:1937-8688
[Cp] Country of publication:Uganda
[La] Language:eng
[Ab] Abstract:Introduction: Epidemiological evidence strongly suggests that steroid hormones are implicated in the pathogenesis of ovarian cancer. Estrogen receptor (ER) and Progesterone receptor (PR) are prognostic indicators for a number of epithelial tumors and may play the same role in ovarian cancers. This study aims to evaluate the expression of ER and PR in epithelial ovarian cancer (EOC) in an African population and compare it with other prognostic factors such as age, International Federation of Gynaecology and Obstetrics (FIGO) stage, grade and histological subtype. Methods: Ninety cases of histologically confirmed EOC were reviewed. Immunohistochemistry was used to assess their ER and PR expression status and was then compared with other demographic variables using statistical methods, with level of significance set at p < 0.05. Results: 30.2% and 8.3% of serous and mucinous carcinomas respectively were ER positive while 41.2% and 22.5% of both tumour types were PR positive. One of the two endometrioid carcinomas showed PR expression but neither were positive for ER. The only case of Brenner tumour in the series was ER positive but negative for PR. There was a significant association between ER and the histological subtypes (p = 0.042) while no significant association was found between PR expression and histological subtypes (p = 0.650). No significant association was found between hormone receptor status, age and stage of the EOC. Conclusion: The study showed a lower ER expression in serous carcinoma compared to large cohorts from developed countries. Future translational studies could be used to determine response of EOC to endocrine therapy.
[Mh] MeSH terms primary: Neoplasms, Glandular and Epithelial/epidemiology
Ovarian Neoplasms/epidemiology
Receptors, Estrogen/genetics
Receptors, Progesterone/genetics
[Mh] MeSH terms secundary: Adenocarcinoma, Mucinous/epidemiology
Adenocarcinoma, Mucinous/genetics
Adenocarcinoma, Mucinous/pathology
Adolescent
Adult
Aged
Aged, 80 and over
Brenner Tumor/epidemiology
Brenner Tumor/genetics
Brenner Tumor/pathology
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Middle Aged
Neoplasms, Glandular and Epithelial/genetics
Neoplasms, Glandular and Epithelial/pathology
Nigeria/epidemiology
Ovarian Neoplasms/genetics
Ovarian Neoplasms/pathology
Prognosis
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Receptors, Estrogen); 0 (Receptors, Progesterone)
[Em] Entry month:1712
[Cu] Class update date: 171219
[Lr] Last revision date:171219
[Js] Journal subset:IM
[Da] Date of entry for processing:171201
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.259.11883

  3 / 651 MEDLINE  
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[PMID]: 29198156
[Au] Autor:Tamás J; Vereczkey I; Tóth E; Csernák E; Purcsi K; Pete I
[Ad] Address:1 National Institute of Oncology, Budapest, Hungary.
[Ti] Title:Mixed Ovarian Tumor Composed of Brenner Tumor and Adult-Type Granulosa Cell Tumor: A Case Report of a Very Rare Mixed Ovarian Tumor and a Review of the Literature.
[So] Source:Int J Surg Pathol;:1066896917744877, 2017 Nov 01.
[Is] ISSN:1940-2465
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:A combination of ovarian tumors with the same histogenetic origin but different histologic subtype is relatively common, whereas a co-occurrence of tumors with different histogenetic origin is rare. We report a case of mixed ovarian tumor composed of Brenner tumor and adult-type granulosa cell tumor, a combination that to the best of our knowledge has not been reported in the literature until now.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 171204
[Lr] Last revision date:171204
[St] Status:Publisher
[do] DOI:10.1177/1066896917744877

  4 / 651 MEDLINE  
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[PMID]: 29194872
[Au] Autor:Cozzi DA; Ceccanti S; Cozzi F
[Ad] Address:Pediatric Surgery Unit, Sapienza University of Rome, Azienda Policlinico Umberto I, Rome, RM, 00161, Italy.
[Ti] Title:Renal Function up to the 5 Decade of Life After Nephrectomy in Childhood: A Literature Review.
[So] Source:Nephrology (Carlton);, 2017 Nov 30.
[Is] ISSN:1440-1797
[Cp] Country of publication:Australia
[La] Language:eng
[Ab] Abstract:The aim of present study was to find out if in children ablation of 50% of renal mass may be associated with a progressive renal damage (Brenner's hypothesis). We collected 1035 adult or adolescent survivors who underwent during childhood nephrectomy for unilateral oncological or non-oncological causes. Stratification of all survivors for age revealed that the number of subjects with blood hypertension and/or renal dysfunction (glomerular filtration rate <90 ml/min/1.73m ) to be significantly higher in survivors ≥30year-old in comparison with younger patients. Available data on long-term renal function after nephrectomy during childhood support the Brenner's hypothesis.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1712
[Cu] Class update date: 171201
[Lr] Last revision date:171201
[St] Status:Publisher
[do] DOI:10.1111/nep.13202

  5 / 651 MEDLINE  
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[PMID]: 29149401
[Au] Autor:Telerman A; Amson R
[Ad] Address:Bâtiment B2M, Institut Gustave Roussy, Unité Inserm U981, 114 rue Édouard-Vaillant, 94805, Villejuif, France. atelerman@gmail.com.
[Ti] Title:Introduction: How We Encountered TCTP and Our Purpose in Studying It.
[So] Source:Results Probl Cell Differ;64:1-8, 2017.
[Is] ISSN:0080-1844
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:In this brief introduction, we describe our encounter with TCTP. Back in 2000, we discovered TCTP in two quite different ways: first, we looked at protein partners of TSAP6 and one of them was TCTP. Then, in collaboration with Sidney Brenner, we performed a high-throughput differential screening comparing the parental cancer cells with revertants. The results indicated that TCTP was of the most differentially expressed genes. These two approaches were carried out only months apart. They guided our research and led to the discoveries of drugs that inhibit the function of TCTP. Much of the preclinical data on sertraline as an inhibitor of TCTP in cancer were obtained with Judith Karp at Johns Hopkins. This drug is now given in combination with Ara-C to patients in a phase I clinical trial for Acute Myeloid Leukemia. We will here detail how all this happened in our lab while working around one central project: tumor reversion.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171117
[Lr] Last revision date:171117
[St] Status:In-Data-Review
[do] DOI:10.1007/978-3-319-67591-6_1

  6 / 651 MEDLINE  
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[PMID]: 28984773
[Au] Autor:Jeon H; Ryu A; Seo HG; Jang SH
[Ad] Address:Department of Obstetrics and Gynecology, Department of Pathology, Soonchunhyang University College of Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
[Ti] Title:Ovarian torsion of mixed epithelial tumor misdiagnosed as a malignancy in postmenopausal woman: A case report.
[So] Source:Medicine (Baltimore);96(40):e8207, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:RATIONALE: Adnexal torsion is 1 of the most common emergency gynecological disease. It is more often diagnosed in reproductive age, but rarely in postmenopausal women. The clinical symptoms of adnexal torsion are nonspecific in postmenopausal women. Epithelial ovarian tumors are common in adults, and the risk of malignancy increases with age, especially after menopause. So, it is difficult to diagnose adnexal torsion precisely compared with reproductive women, and most cases of adnexal torsion with postmenopausal women are diagnosed as a malignancy preoperatively. We report a case of ovarian torsion with mixed epithelial tumor misdiagnosed as a malignancy in postmenopausal woman. PATIENT CONCERNS: A 65-year-old woman presented lower left abdominal pain, and there was slight abdominal distension, but no tenderness or rebound tenderness on abdominal palpation. DIAGNOSES: Radiologic assessments showed a huge multiseptated cystic mass with solid portion in the left ovary, and malignancy was suspected. The test for serum tumor markers revealed normal levels of cancer antigen 125 (CA-125). INTERVENTIONS: The patient underwent a laparotomy and there was torsion of the left ovary. We conducted frozen biopsy of left ovary for confirming malignancy before performing staging surgery. OUTCOMES: The result of a frozen section biopsy confirmed a borderline Brenner tumor associated with a benign mucinous tumor. Subsequently, total hysterectomy and right salpingo-oophorectomy were performed. The operation was completed without addition procedures LESSONS:: Ovarian torsion is benign in most cases and malignancy is rare. Although very rare, ovarian torsion can occur in postmenopausal women, and it should be taken into consideration that the possibility of malignancy is low in postmenopausal women with normal CA-125 levels. Instead of performing staging surgery, it appears to be appropriate to carry out surgery based on the result of intraoperative frozen section biopsy so that we were able to avoid unnecessary surgical procedures.
[Mh] MeSH terms primary: Brenner Tumor/diagnosis
Diagnostic Errors
Ovarian Neoplasms/diagnosis
Ovary/abnormalities
Torsion Abnormality/diagnosis
[Mh] MeSH terms secundary: Aged
Biomarkers, Tumor/analysis
Brenner Tumor/pathology
Brenner Tumor/surgery
CA-125 Antigen/analysis
Female
Frozen Sections
Humans
Ovarian Neoplasms/pathology
Ovarian Neoplasms/surgery
Ovariectomy/methods
Ovary/pathology
Ovary/surgery
Postmenopause
Torsion Abnormality/pathology
Torsion Abnormality/surgery
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Nm] Name of substance:0 (Biomarkers, Tumor); 0 (CA-125 Antigen)
[Em] Entry month:1710
[Cu] Class update date: 171012
[Lr] Last revision date:171012
[Js] Journal subset:AIM; IM
[Da] Date of entry for processing:171007
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008207

  7 / 651 MEDLINE  
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[PMID]: 28971141
[Au] Autor:Lang SM; Mills AM; Cantrell LA
[Ad] Address:University of Virginia School of Medicine, Charlottesville, VA 22903, United States.
[Ti] Title:Malignant Brenner tumor of the ovary: Review and case report.
[So] Source:Gynecol Oncol Rep;22:26-31, 2017 Nov.
[Is] ISSN:2352-5789
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:Ovarian neoplasms are a heterogeneous group of tumors with varying incidence in the general population. The most common are the surface epithelial tumors which include transitional cell tumors. Transitional cell tumors include both transitional cell carcinoma and Brenner tumor. The vast majority of Brenner tumors are benign, often incidental findings; however, malignant Brenner tumors (MBT) do occasionally occur. MBT present similarly to other ovarian neoplasms with abdominal pain and bulk symptoms. On imaging, these tumors demonstrate nonspecific findings. Microscopically, they demonstrate areas of conventional benign Brenner tumor juxtaposed with regions of frank malignancy showing marked cytologic atypia and infiltration. There is no consistent tumor marker for these tumors, but CA-125, CA 72-4 and SCC have been reported in singular instances. Tumors express several immunohistochemical markers of urothelial differentiation including uroplakin III, thrombomodulin, GATA3, p63, as well as cytokeratin 7. The primary treatment modality is surgical excision. Due to their rarity, the precise role and regimen of adjuvant chemo-radiation therapy for MBT has not been established. We herein review a case of MBT with emphasis on primary treatment and treatment of recurrent disease, including the use of adjuvant pelvic radiation, discuss the current state of the literature and standards of practice regarding this malignancy.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171006
[Lr] Last revision date:171006
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1016/j.gore.2017.07.001

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[PMID]: 28913150
[Au] Autor:Turgay B; Koyuncu K; Taskin S; Ortaç UF
[Ad] Address:Ankara University Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey.
[Ti] Title:Features of ovarian Brenner tumors: Experience of a single tertiary center.
[So] Source:Turk J Obstet Gynecol;14(2):133-137, 2017 Jun.
[Is] ISSN:2149-9322
[Cp] Country of publication:Turkey
[La] Language:eng
[Ab] Abstract:OBJECTIVE: Brenner tumors are rare neoplasms of the ovary. The aim of this study was to investigate the clinical features of Brenner tumors. MATERIALS AND METHODS: The clinical features of 22 patients who were treated in Ankara University Faculty of Medicine Obstetrics and Gynecology Department between 2005 and 2015 were evaluated retrospectively from hospital medical records. RESULTS: The patients were aged 34 to 79 years at the time of diagnosis and the mean age was 55.1 years. Two (9.1%) patients were pre-menopausal, five (22.7%) were peri-menopausal, and 25 (68.2%) patients were postmenopausal. One patient was pregnant. Twenty of the neoplasms were benign, one was malignant, and one was both malignant and benign. There was no recurrence in the malignant cases. Six (27.2%) patients had mixed tumors consisting of Brenner tumor and another ovarian pathology. Specifically, the other component of these tumors was mucinous cystadenoma in four patients, endometriosis externa in one patient, and high-grade serous papillary cyst adenocarcinoma in one patient. CONCLUSION: Brenner tumors are usually incidental benign pathologic findings of surgical procedures in postmenopausal women. They can be found with other ovarian pathologies such as mucinous ovarian tumors and can coexist with other female genital tumors. Further studies are needed to completely understand the clinical features of Brenner tumors.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170917
[Lr] Last revision date:170917
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4274/tjod.98216

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[PMID]: 28821472
[Au] Autor:Harvey LFB; Abramson VG; Alvarez J; Destephano C; Hur HC; Lee K; Mattingly P; Park B; Piszczek C; Seifi F; Stuparich M; Yunker A
[Ad] Address:Division of Minimally Invasive Gynecology, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: Lara.harvey@vanderbilt.edu.
[Ti] Title:Surgical Findings and Outcomes in Premenopausal Breast Cancer Patients Undergoing Oophorectomy: A Multicenter Review From the Society of Gynecologic Surgeons Fellows Pelvic Research Network.
[So] Source:J Minim Invasive Gynecol;, 2017 Aug 15.
[Is] ISSN:1553-4669
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:STUDY OBJECTIVE: To describe the procedures performed, intra-abdominal findings, and surgical pathology in a cohort of women with premenopausal breast cancer who underwent oopherectomy. DESIGN: Multicenter retrospective chart review (Canadian Task Force classification II-3). SETTING: Nine US academic medical centers participating in the Fellows' Pelvic Research Network (FPRN). PATIENTS: One hundred twenty-seven women with premenopausal breast cancer undergoing oophorectomy between January 2013 and March 2016. INTERVENTION: Surgical castration. MEASUREMENTS AND MAIN RESULTS: The mean patient age was 45.8 years. Fourteen patients (11%) carried a BRCA mutations, and 22 (17%) carried another germline or acquired mutation, including multiple variants of uncertain significance. There was wide variation in surgical approach. Sixty-five patients (51%) underwent pelvic washings, and 43 (35%) underwent concurrent hysterectomy. Other concomitant procedures included midurethral sling placement, appendectomy, and hysteroscopy. Three patients experienced complications (transfusion, wound cellulitis, and vaginal cuff dehiscence). Thirteen patients (10%) had ovarian pathology detected on analysis of the surgical specimen, including metastatic tumor, serous cystadenomas, endometriomas, and Brenner tumor. Eight patients (6%) had Fallopian tube pathology, including 3 serous tubal intraepithelial cancers. Among the 44 uterine specimens, 1 endometrial adenocarcinoma and 1 multifocal endometrial intraepithelial neoplasia were noted. Regarding the entire study population, the number of patients meeting our study criteria and seen by gynecologic surgeons in the FPRN for oophorectomy increased by nearly 400% from 2013 to 2015. CONCLUSION: Since publication of the Suppression of Ovarian Function Trial data, bilateral oophorectomy has been recommended for some women with premenopausal breast cancer to facilitate breast cancer treatment with aromatase inhibitors. These women may be at elevated risk for occult abdominal pathology compared with the general population. Gynecologic surgeons often perform castration oophorectomy in patients with breast cancer as an increasing number of oncologists are using aromatase inhibitors to treat premenopausal breast cancer. Our data suggest that other abdominal/pelvic cancers, precancerous conditions, and previously unrecognized metastatic disease are not uncommon findings in this patient population. Gynecologists serving this patient population may consider a careful abdominal survey, pelvic washings, endometrial sampling, and serial sectioning of fallopian tube specimens for a thorough evaluation.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1708
[Cu] Class update date: 171023
[Lr] Last revision date:171023
[St] Status:Publisher

  10 / 651 MEDLINE  
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[PMID]: 28706410
[Au] Autor:Sharma M; Khangar B; Mallya V; Khurana N; Gupta S
[Ad] Address:Department of Pathology, Maulana Azad Medical College, New Delhi, India.
[Ti] Title:Coexisting Brenner Tumor and Endometrial Carcinoma.
[So] Source:J Midlife Health;8(2):89-91, 2017 Apr-Jun.
[Is] ISSN:0976-7800
[Cp] Country of publication:India
[La] Language:eng
[Ab] Abstract:Brenner tumor is a rare ovarian neoplasm that is seen in women of the fifth to sixth decade. Classified as benign, borderline, and malignant, these tumors may be associated with estrogen production, thus altering the estrogen-progesterone ratio. High estrogen stimulates the endometrium and this is responsible for producing various pathologies, namely, hyperplasia, atypia, and carcinoma. Very few case reports have been published highlighting the same. A case report is being presented here of a coexisting Brenner tumor and well-differentiated endometrial carcinoma in a 55-year-old nulliparous postmenopausal woman.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1707
[Cu] Class update date: 170717
[Lr] Last revision date:170717
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.4103/jmh.JMH_3_17


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