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[PMID]: | 29501247 | [Au] Autor: | Ciprandi G; Schiavetti I; Ricciardolo FLM |
[Ad] Address: | Ospedale Policlinico San Martino, Genoa, Italy. Electronic address: gio.cip@libero.it. | [Ti] Title: | The impact of aging on outpatients with asthma in a real-world setting. | [So] Source: | Respir Med;136:58-64, 2018 Mar. | [Is] ISSN: | 1532-3064 | [Cp] Country of publication: | England | [La] Language: | eng | [Ab] Abstract: | BACKGROUND: Asthma is characterized by airway inflammation and bronchial hyperreactivity. It is conceived that aging may affect asthma characteristics, but this issue is still not completely clarified in clinical practice. OBJECTIVE: The present study investigated whether aging may affect some clinical and functional factors in outpatients with asthma visited in a real-world setting, such as clinical practice. METHODS: Globally, 391 outpatients (163 males, median age 47 years) with asthma were consecutively evaluated. The following parameters were assessed: history, including, smoking, comorbidity, and inhaled corticosteroids (ICS) use, physical examination, body mass index (BMI), lung function, level of asthma control, asthma control test (ACT), and fractional exhaled NO (FeNO). RESULTS: The elderly with asthma had: more frequently not controlled asthma, higher BMI, higher ICS dosages, more impaired lung function, including plethysmographic parameters, than adult asthmatics (p < 0.001 for all, but p = 0.002 for RV and p = 0.008 for FRC). Elderly asthmatics were also less frequently allergic (p < 0.001) and had less rhinitis comorbidity (p < 0.001) and less nasal symptoms (p < 0.05) than younger asthmatics. CONCLUSIONS: The present study conducted in a real-world setting shows that aging significantly affects asthma, mainly concerning asthma control, lung function, and steroid-sensitivity. | [Pt] Publication type: | JOURNAL ARTICLE | [Em] Entry month: | 1803 | [Cu] Class update date: |
180304 | [Lr] Last revision date: | 180304 | [St] Status: | In-Data-Review |
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