Database : MEDLINE
Search on : Bronchial and Hyperreactivity [Words]
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[PMID]: 29523832
[Au] Autor:Ji Y; Chen S; Wang Q; Xiang B; Xu Z; Zhong L; Yang K; Lu G; Qiu L
[Ad] Address:Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China. jijiyuanyuan@163.com.
[Ti] Title:Intolerable side effects during propranolol therapy for infantile hemangioma: frequency, risk factors and management.
[So] Source:Sci Rep;8(1):4264, 2018 Mar 09.
[Is] ISSN:2045-2322
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Currently, propranolol is the most preferred systemic therapy for problematic infantile hemangiomas (IHs). However, the side effects such as bronchial hyperreactivity may be intolerable. The aim of this study was to evaluate the frequency, risk factors and management of intolerable side effects (ISEs) during propranolol therapy. In total, 1260 children were studied. The incidence of ISEs was 2.1% (26 patients). Severe sleep disturbance was the most common reason for propranolol cessation, accounting for 65.4% of cases. In total, 23 and 3 patients received atenolol and prednisolone as second-line therapy, respectively. Treatment response was observed in 92.3% (24/26) of cases (showing excellent or good response to therapy). No toxicity-related permanent treatment discontinuation occurred during atenolol or prednisolone therapy. In the univariate analysis, younger age, premature birth, and lower body weight were associated with ISEs (P < 0.05). In the multivariate analysis, only age (95% confidence interval [CI]: 1.201-2.793, P = 0.009) and body weight (95% CI: 1.036-1.972, P = 0.014) were associated with ISEs. Our study suggests that ISEs are rare in patients with IHs who are treated with propranolol. Predictive factors for ISEs include younger age and lower body weight. Atenolol and prednisolone are effective and safe alternatives to propranolol in the treatment of refractory IHs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180310
[Lr] Last revision date:180310
[St] Status:In-Data-Review
[do] DOI:10.1038/s41598-018-22787-8

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[PMID]: 29522998
[Au] Autor:Erbas B; Knudsen TM; Janson C; Nilsen RM; Accordini S; Benediktdottir B; Dratva J; Heinrich J; Jarvis D; Leynaert B; Matheson MC; Norbäck D; Real FG; Raherison-Semjen C; Villani S; Dharmage SC; Svanes C
[Ad] Address:Department of Public Health, La Trobe University, Melbourne, Australia. Electronic address: b.erbas@latrobe.edu.au.
[Ti] Title:Critical age windows in the impact of lifetime smoking exposure on respiratory symptoms and disease among ever smokers.
[So] Source:Environ Res;164:241-247, 2018 Mar 06.
[Is] ISSN:1096-0953
[Cp] Country of publication:Netherlands
[La] Language:eng
[Ab] Abstract:BACKGROUND: Despite extensive knowledge of smoking effects on respiratory disease, there is no study including all age windows of exposure among ever smokers. The objective of this study was to assess the effects from smoking exposure in utero, early childhood, adolescence and adulthood on respiratory health outcomes in adult male and female ever smokers. METHODS: Respiratory health outcomes were assessed in 10,610 participants of the European Community Respiratory Health Survey (ECRHS) I who reported a history of ever smoking by questionnaire. The associations of maternal smoking in utero, maternal smoking during childhood, age of smoking debut and pack-years of smoking with respiratory symptoms, obstructive diseases and bronchial hyperreactivity were analysed using generalized linear regression, non-linearity between age of smoking debut and outcomes were assessed by Generalized additive mixed models. RESULTS: Respiratory symptoms and asthma were more frequent in adults if their mother smoked during pregnancy, and, in men, also if mother smoked in childhood. Wheeze and ≥3 respiratory symptoms declined with later smoking debut among women [≤10 years: OR = 3.51, 95% CI 1.26, 9.73; 11-12 years: 1.57[1.01-2.44]; 13-15 years: 1.11[0.94-1.32] and ≤10 years: 3.74[1.56-8.83]; 11-12 years: 1.76[1.19-2.56]; 13-15 years: 1.12[0.94-1.35], respectively]. Effects of increasing number of packyears were pronounced in women (Chronic Obstructive Pulmonary Disease (COPD): OR/10 packyears women: 1.33 [1.18, 1.50], men: 1.14 [1.04, 1.26] p = 0.01). CONCLUSIONS: Among ever smokers, smoking exposure in each stage of the lifespan show persistent harmful effects for adult respiratory health, while women appeared to be more vulnerable to an early age of smoking debut and amount of smoking in adulthood.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180309
[Lr] Last revision date:180309
[St] Status:Publisher

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[PMID]: 29284904
[Au] Autor:Cukic V
[Ad] Address:Clinic for Pulmonary Diseases and Tuberculosis "Podhrastovi", Clinical Centre of Sarajevo University, Bosnia and Herzegovina.
[Ti] Title:Blood Count of Eosinophil Polymorphonuclear Leucocytes and Bronchial Hyperreactivity in Chronic Obstructive Pulmonary Disease.
[So] Source:Med Arch;71(5):347-350, 2017 Oct.
[Is] ISSN:0350-199X
[Cp] Country of publication:Bosnia and Herzegovina
[La] Language:eng
[Ab] Abstract:Introduction: Polymorphonuclear eosinophil leucocytes (eosinophils) are found in increased numbers in the circulation and sputum in asthma patients, usually in relation to the severity of asthma but it is the question whether they have a significant role in the development and level of bronchial hyperreactivity in patients with chronic obstructive pulmonary disease (COPD). Objective: to show the role of the eosinophils in the development and level of BHR in patients with COPD and so in the severity of illness. Material and methods: We observed 240 patients with COPD treated in Clinic for Pulmonary Diseases and TB «Podhrastovi¼ Sarajevo during five years: from 2012 to 2016. They were divided into groups and subgroups according to the first registration of BHR in the course of illness and to the number of exacerbations of the disease in one year. The number of blood eosinophils was measured at the onset of exacerbation of the disease before switching on any therapy, at the beginning and at the end of the research. Results: we did not find any significant difference in the eosinophil blood count between the COPD patients with and without BHR, nor according to the time of the first registration of BHR in the course of illness nor according to the number of exacerbations of illness per one year. There was not statistically significant difference in eosinophil count (increase-drop) within any of the groups or subgroups, or between the groups and subgroups between the first and last test. Conclusion: There is not significant correlation between the eosinophil blood count and the level of BHR, number of exacerbations and the severity of COPD.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1712
[Cu] Class update date: 180307
[Lr] Last revision date:180307
[St] Status:In-Process
[do] DOI:10.5455/medarh.2017.71.347-350

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[PMID]: 29501247
[Au] Autor:Ciprandi G; Schiavetti I; Ricciardolo FLM
[Ad] Address:Ospedale Policlinico San Martino, Genoa, Italy. Electronic address: gio.cip@libero.it.
[Ti] Title:The impact of aging on outpatients with asthma in a real-world setting.
[So] Source:Respir Med;136:58-64, 2018 Mar.
[Is] ISSN:1532-3064
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Asthma is characterized by airway inflammation and bronchial hyperreactivity. It is conceived that aging may affect asthma characteristics, but this issue is still not completely clarified in clinical practice. OBJECTIVE: The present study investigated whether aging may affect some clinical and functional factors in outpatients with asthma visited in a real-world setting, such as clinical practice. METHODS: Globally, 391 outpatients (163 males, median age 47 years) with asthma were consecutively evaluated. The following parameters were assessed: history, including, smoking, comorbidity, and inhaled corticosteroids (ICS) use, physical examination, body mass index (BMI), lung function, level of asthma control, asthma control test (ACT), and fractional exhaled NO (FeNO). RESULTS: The elderly with asthma had: more frequently not controlled asthma, higher BMI, higher ICS dosages, more impaired lung function, including plethysmographic parameters, than adult asthmatics (p < 0.001 for all, but p = 0.002 for RV and p = 0.008 for FRC). Elderly asthmatics were also less frequently allergic (p < 0.001) and had less rhinitis comorbidity (p < 0.001) and less nasal symptoms (p < 0.05) than younger asthmatics. CONCLUSIONS: The present study conducted in a real-world setting shows that aging significantly affects asthma, mainly concerning asthma control, lung function, and steroid-sensitivity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1803
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:In-Data-Review

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[PMID]: 29444897
[Au] Autor:Haspeslagh E; van Helden MJ; Deswarte K; De Prijck S; van Moorleghem J; Boon L; Hammad H; Vivier E; Lambrecht BN
[Ad] Address:Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.
[Ti] Title:Role of NKp46 natural killer cells in house dust mite-driven asthma.
[So] Source:EMBO Mol Med;, 2018 Feb 14.
[Is] ISSN:1757-4684
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:House dust mite (HDM)-allergic asthma is driven by T helper 2 (Th2) lymphocytes, but also innate immune cells control key aspects of the disease. The precise function of innate natural killer (NK) cells during the initiation and propagation of asthma has been very confusing, in part because different, not entirely specific, strategies were used to target these cells. We show that HDM inhalation rapidly led to the accumulation of NK cells in the lung-draining lymph nodes and of activated CD69 NK cells in the bronchoalveolar lumen. However, genetically engineered -DTA or -DTR mice that constitutively or temporarily lack NK cells, still developed all key features of acute or chronic HDM-driven asthma, such as bronchial hyperreactivity, Th2 cytokine production, eosinophilia, mucus overproduction, and Th2-dependent immunoglobulin serum titers. The same results were obtained by administration of conventional NK1.1 or asialo-GM1 NK cell-depleting antibodies, antibody-mediated blocking of the NKG2D receptor, or genetic NKG2D deficiency. Thus, although NK cells accumulate in allergen-challenged lungs, our findings comprehensively demonstrate that these cells are not required for HDM-driven asthma in the mouse.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180215
[Lr] Last revision date:180215
[St] Status:Publisher

  6 / 9493 MEDLINE  
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[PMID]: 29438818
[Au] Autor:Johansson EL; Ternesten-Hasséus E; Gustafsson P; Pullerits T; Arvidsson M; Millqvist E
[Ad] Address:Departments of Clinical Neuroscience and Rehabilitation, Physiotherapy, The Sahlgrenska Academy, University of Gothenburg, Sweden. Electronic address: ewa-lena.johansson@vgregion.se.
[Ti] Title:Small and large airway reactions to osmotic stimuli in asthma and chronic idiopathic cough.
[So] Source:Pulm Pharmacol Ther;, 2018 Feb 10.
[Is] ISSN:1522-9629
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Chronic cough is a common symptom and related to several pulmonary, airway and heart diseases. When all likely medical explanations for the coughing are excluded, there remains a large group of patients with chronic coughing, which is mostly a cough reflex easily triggered by environmental irritants and noxious stimuli. The main aim of this study was to improve the diagnostic ability to differentiate chronic idiopathic cough (CIC) from asthma. METHODS: Twenty-three patients with CIC, 16 patients with mild asthma and 21 control participants were included. The study consisted of three randomised bronchial provocations with osmotic stimuli: mannitol, eucapnic dry air and hypertonic saline. At each provocation lung function was assessed by spirometry and impulse oscillometry (IOS). RESULTS: In a comparison of the groups, while the FEV measurements did not differ, the CIC group had increased airway resistance and reactance after provocation with hypertonic saline compared to the control subjects. After mannitol provocation the patients with asthma had significantly increased airway resistance compared to the controls and from eucapnic dry air provocations these patients had a significant reduction in spirometry values and increased airway resistance compared to both the patients with CIC and the controls. CONCLUSION: The asthma group reacted in a predictable way with impaired lung function from osmotic provocations, whereas the patients with CIC demonstrated peripheral airway changes from hypertonic saline, also known to be a noxious stimulus. The IOS method uncovers differences between patients with CIC and control participants that contribute to our ability to provide a correct diagnosis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[St] Status:Publisher

  7 / 9493 MEDLINE  
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[PMID]: 29338164
[Au] Autor:Novkovic D; Petrovic M; Zivkovic V; Baletic N
[Ti] Title:The relation between nonspecific hyperreactivity of the airways and atopic constitution in asthmatics.
[So] Source:Vojnosanit Pregl;73(11):1056-9, 2016 Nov.
[Is] ISSN:0042-8450
[Cp] Country of publication:Serbia
[La] Language:eng
[Ab] Abstract:Background/Aim: Hyperreactivity of the airways caused by inflammation in asthmatics is the most important pathophysiological change. It represents a suitable ground that in the presence of risk factors and the drivers of asthma, asthmatic attack occurs. Atopic constitution is one of the most important risk factors for the development and expression of asthma. The aim of our study was to investigate the relationship between nonspecific airway hyperreactivity and atopic constituton in asthmatics. Methods: This retrospective analysis was conducted considering the results of nonspecific bronchoprovocative test with histamine, skin tests to inhalant allergens and total IgE levels in the serum of asthmatic patients with controlled bronchial asthma. The sample consisted of 162 asthmatics examined during one-year period. Results: The examinees were male asthmatic patients, aged between 18 and 30 years. We found that the examinees with a pronounced non-specific hyperreactivity had more significant skin reaction to inhaled allergens and higher levels of total IgE in serum. Conclusion: The results of our study show that the intensity of airway hyperresponsiveness to histamine in asthmatics is directly related to atopic constitution.
[Mh] MeSH terms primary: Asthma/physiopathology
Bronchial Hyperreactivity/physiopathology
Bronchoconstriction
Dermatitis, Atopic/immunology
Lung/physiopathology
[Mh] MeSH terms secundary: Administration, Inhalation
Adolescent
Adult
Asthma/diagnosis
Asthma/immunology
Biomarkers/blood
Bronchial Hyperreactivity/diagnosis
Bronchial Hyperreactivity/immunology
Bronchial Provocation Tests
Dermatitis, Atopic/blood
Dermatitis, Atopic/diagnosis
Histamine/administration & dosage
Humans
Immunoglobulin E/blood
Lung/immunology
Male
Retrospective Studies
Risk Factors
Skin Tests
Young Adult
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Biomarkers); 37341-29-0 (Immunoglobulin E); 820484N8I3 (Histamine)
[Em] Entry month:1802
[Cu] Class update date: 180213
[Lr] Last revision date:180213
[Js] Journal subset:IM
[Da] Date of entry for processing:180118
[St] Status:MEDLINE
[do] DOI:10.2298/VSP141029120N

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[PMID]: 28742120
[Au] Autor:Skappak C; Ilarraza R; Wu YQ; Drake MG; Adamko DJ
[Ad] Address:Division of Emergency Medicine, McMaster University, Hamilton, Ontario, Canada.
[Ti] Title:Virus-induced asthma attack: The importance of allergic inflammation in response to viral antigen in an animal model of asthma.
[So] Source:PLoS One;12(7):e0181425, 2017.
[Is] ISSN:1932-6203
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Asthma exacerbation can be a life-threatening condition, and is most often triggered by common respiratory viruses. Poor asthma control and worsening of respiratory function is associated with increased airway inflammation, including eosinophilia. Prevention of asthma exacerbation relies on treatment with corticosteroids, which preferentially inhibit allergic inflammation like eosinophils. Human studies demonstrate that inactivated virus can trigger eosinophil activation in vitro through antigen presentation and memory CD4+ lymphocytes. We hypothesized that animals with immunologic memory to a respiratory virus would also develop airway hyperresponsiveness in response to a UV-inactivated form of the virus if they have pre-existing allergic airway inflammation. Guinea pigs were ovalbumin-sensitized, infected with live parainfluenza virus (PIV), aerosol-challenged with ovalbumin, and then re-inoculated 60 days later with live or UV-inactivated PIV. Some animals were either treated with dexamethasone prior to the second viral exposure. Lymphocytes were isolated from parabronchial lymph nodes to confirm immunologic memory to the virus. Airway reactivity was measured and inflammation was assessed using bronchoalveolar lavage and lung histology. The induction of viral immunologic memory was confirmed in infected animals. Allergen sensitized and challenged animals developed airway hyperreactivity with eosinophilic airway inflammation when re-exposed to UV-inactivated PIV, while non-sensitized animals did not. Airway hyperreactivity in the sensitized animals was inhibited by pre-treatment with dexamethasone. We suggest that the response of allergic inflammation to virus antigen is a significant factor causing asthma exacerbation. We propose that this is one mechanism explaining how corticosteroids prevent virus-induced asthma attack.
[Mh] MeSH terms primary: Asthma/virology
Parainfluenza Virus 1, Human/immunology
Respiratory Hypersensitivity/virology
Respirovirus Infections/complications
[Mh] MeSH terms secundary: Animals
Anti-Inflammatory Agents/therapeutic use
Asthma/drug therapy
Asthma/immunology
Dexamethasone/therapeutic use
Disease Models, Animal
Female
Guinea Pigs
Humans
Immunologic Memory/drug effects
Inflammation/drug therapy
Inflammation/immunology
Inflammation/virology
Lymphocytes/immunology
Lymphocytes/virology
Respiratory Hypersensitivity/drug therapy
Respiratory Hypersensitivity/immunology
Respirovirus Infections/drug therapy
Respirovirus Infections/immunology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Inflammatory Agents); 7S5I7G3JQL (Dexamethasone)
[Em] Entry month:1709
[Cu] Class update date: 180207
[Lr] Last revision date:180207
[Js] Journal subset:IM
[Da] Date of entry for processing:170726
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181425

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[PMID]: 29359169
[Au] Autor:Gao H; Ying S; Dai Y
[Ad] Address:Department of Respiratory Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
[Ti] Title:Pathological Roles of Neutrophil-Mediated Inflammation in Asthma and Its Potential for Therapy as a Target.
[So] Source:J Immunol Res;2017:3743048, 2017.
[Is] ISSN:2314-7156
[Cp] Country of publication:Egypt
[La] Language:eng
[Ab] Abstract:Asthma is a chronic inflammatory disease that undermines the airways. It is caused by dysfunction of various types of cells, as well as cellular components, and is characterized by recruitment of inflammatory cells, bronchial hyperreactivity, mucus production, and airway remodelling and narrowing. It has commonly been considered that airway inflammation is caused by the Th2 immune response, or eosinophilia, which is a hallmark of bronchial asthma pathogenesis. Some patients display a neutrophil-dominant presentation and are characterized with low (or even absent) Th2 cytokines. In recent years, increasing evidence has also suggested that neutrophils play a key role in the development of certain subtypes of asthma. This review discusses neutrophils in asthma and potentially related targeted therapies.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1801
[Cu] Class update date: 180123
[Lr] Last revision date:180123
[St] Status:In-Process
[do] DOI:10.1155/2017/3743048

  10 / 9493 MEDLINE  
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[PMID]: 29345235
[Au] Autor:D'Amato M; Cecchi L; Annesi-Maesano I; D'Amato G
[Ad] Address:First Division of Pneumology, High Speciality Hospital "V. Monaldi" and University "Federico II" Medical School, Napoli, Italy.
[Ti] Title:News on Climate change, air pollution and allergic trigger factors of asthma.
[So] Source:J Investig Allergol Clin Immunol;:0, 2018 01 17.
[Is] ISSN:1018-9068
[Cp] Country of publication:Spain
[La] Language:eng
[Ab] Abstract:The rising frequency of obstructive respiratory diseases,in particular allergic asthma, observed over the last years, can be partially explained by changes occurring in the environment, with increasing presence in atmosphere of chemical (particulate matter and gaseous components such as nitrogen dioxide and ozone) and biologic (aeroallergens) trigger factors. Aeroallergens are able to stimulate, in allergic subjects, the airways' sensitization, inducing symptoms of bronchial asthma. Over the last 50 years, global earth's temperature has markedly risen likely because of growing emission of anthropogenic greenhouse gas concentrations. Major changes involving the atmosphere and the climate, including global warming induced by human activity, have a major impact on the biosphere and human environment. Urbanization and high levels of vehicle emissions induce symptoms of bronchial obstruction (in particular bronchial asthma) prevalently in people living in urban areas compared with those who live in rural areas. Measures of mitigation need to be applied for reducing future impacts of climate change and global warming on our planet, but until global emissions continue to rise, adaptation to the impacts of future climate variability are required.
[Pt] Publication type:JOURNAL ARTICLE; REVIEW
[Em] Entry month:1801
[Cu] Class update date: 180122
[Lr] Last revision date:180122
[St] Status:Publisher
[do] DOI:10.18176/jiaci.0228


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