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[PMID]: 29104270
[Au] Autor:Xie G; Li R; Han Y; Zhu Y; Wu G; Qin M
[Ad] Address:Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. guoyongxie321@163.com.
[Ti] Title:Optimization of the Extraction Conditions for Buddleja officinalis Maxim. Using Response Surface Methodology and Exploration of the Optimum Harvest Time.
[So] Source:Molecules;22(11), 2017 Nov 01.
[Is] ISSN:1420-3049
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:The Box-Behnken design was used to evaluate the effects of the methanol concentration (60-100%), liquid to solid ratio (20:1 to 40:1 mL/g) and extraction time (20-40 min) on the yield of 11 constituents from Maxim using ultrasound-assisted extraction. The Derringer's desirability function approach showed that the modified optimum extraction conditions were: 76% methanol concentration, 33 min extraction time and a 34:1 mL/g solvent to solid ratio. Under these conditions, the experimentally measured yields of the compounds were in good agreement with the predicted values. An accurate and sensitive method was also established using high-performance liquid chromatography with diode-array detection for the simultaneous determination of the 11 compounds in . The newly developed method was used to determine the amounts of bioactive components in during four different growth stages. According to these results, we recommend that the full blossom stage is the best time for harvesting this plant to obtain the highest yield of crude materials.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1711
[Cu] Class update date: 171106
[Lr] Last revision date:171106
[St] Status:In-Process

  2 / 138 MEDLINE  
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[PMID]: 28981773
[Au] Autor:Ahrazem O; Diretto G; Argandoña J; Rubio-Moraga Á; Julve JM; Orzáez D; Granell A; Gómez-Gómez L
[Ad] Address:Instituto Botánico, Departamento de Ciencia y Tecnología Agroforestal y Genética, Facultad de Farmacia, Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain.
[Ti] Title:Evolutionarily distinct carotenoid cleavage dioxygenases are responsible for crocetin production in Buddleja davidii.
[So] Source:J Exp Bot;68(16):4663-4677, 2017 07 20.
[Is] ISSN:1460-2431
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Crocetin, one of the few colored apocarotenoids known in nature, is present in flowers and fruits and has long been used medicinally and as a colorant. Saffron is the main source of crocetin, although a few other plants produce lower amounts of this apocarotenoid. Notably, Buddleja davidii accumulates crocetin in its flowers. Recently, a carotenoid dioxygenase cleavage enzyme, CCD2, has been characterized as responsible for crocetin production in Crocus species. We searched for CCD2 homologues in B. davidii and identified several CCD enzymes from the CCD1 and CCD4 subfamilies. Unexpectedly, two out of the three CCD4 enzymes, namely BdCCD4.1 and BdCCD4.3, showed 7,8;7',8' activity in vitro and in vivo over zeaxanthin. In silico analyses of these enzymes and CCD2 allowed the determination of key residues for this activity. Both BdCCD4 genes are highly expressed during flower development and transcripts levels parallel the accumulation of crocins in the petals. Phylogenetic analysis showed that BdCCD4.2 grouped with almost all the characterized CCD4 enzymes, while BdCCD4.1 and BdCCD4.3 form a new sub-cluster together with CCD4 enzymes from certain Lamiales species. The present study indicates that convergent evolution led to the acquisition of 7,8;7',8' apocarotenoid cleavage activity in two separate CCD enzyme families.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171013
[Lr] Last revision date:171013
[St] Status:In-Process
[do] DOI:10.1093/jxb/erx277

  3 / 138 MEDLINE  
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[PMID]: 28942684
[Au] Autor:El-Gamal A; Al-Massarani S; Fawzy G; Ati H; Al-Rehaily A; Basudan O; Abdel-Kader M; Tabanca N; Becnel J
[Ad] Address:a Department of Pharmacognosy, College of Pharmacy , King Saud University , Riyadh , Saudi Arabia.
[Ti] Title:Chemical Composition of Buddleja polystachya Aerial Parts and its Bioactivity against Aedes aegypti.
[So] Source:Nat Prod Res;:1-8, 2017 Sep 25.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:A new acylatediridoid glycoside, 6-O-α-L-(2″-acetyl-4″-O-trans-isoferuloyl) rhamnopyranosyl catalpol (9) together with 18 known compounds belonging to the iridoids, flavonoids, triterpene saponin glycosides and phenylethanoids (1-8, 10-18) were isolated from the aerial parts and the flowers of Buddleja polystachya. Their structures were elucidated on the basis of spectroscopic evidence and comparison with that reported in the literature. Promising adulticidal activity was shown for all extracts when tested for adulticidal and larvicidal activities against Ae. aegypti mosquitoes. Therefore, isolated compounds (1-10, 12-14 and 19) were bioassayed for their adulticidal activity. Compound 1 (phytol) was highly active with an LD value of 1.27 ± 0.08 µg/mosquito against adult female Ae. aegypti.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 171027
[Lr] Last revision date:171027
[St] Status:Publisher
[do] DOI:10.1080/14786419.2017.1378213

  4 / 138 MEDLINE  
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[PMID]: 28862057
[Au] Autor:Sun Y; Wang Z; Li B; Sharopov FS; Wang P; Sun Y; Liang Z
[Ad] Address:a College of Life Sciences , Zhejiang Sci-Tech University , Hangzhou , People's Republic of China.
[Ti] Title:Biological characteristics of Edgeworthia tomentosa (Thunb.) Nakai flowers and antimicrobial properties of their essential oils.
[So] Source:Nat Prod Res;:1-4, 2017 Sep 01.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Edgeworthia tomentosa (Thunb.) Nakai belongs to Thymelaeaceae family, its alabastrum is used as the traditional Chinese medicine 'Buddleja Officinalis Maxim'. The present study was to elucidate the ultrastructure characteristics of the flower, the phytochemical composition of the aroma essential oils (EOs) and the relevant antimicrobial properties. There were exclusive characters of calyx, ovule, anther and pollen grain of the flowers under scanning electron microscopy. A total of 40 phytochemical components representing 98% of the EOs were successfully identified: monoterpenes and sesquiterpenes were the dominant terpenoids according to Kovats retention index and MS database. EOs exhibited a broad spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria, the best bacteriostatic effect was against Diplococcus pneumonia with MIC and MBC values ranging between 7.8 and 62.5 and 26.0-71.0 µg/mL, respectively. These results demonstrate that the surface microscopic morphological characteristics of Edgeworthia chrysantha Lindl. flowers, are full-scale chemical composition and antimicrobial properties of the EOs.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1709
[Cu] Class update date: 170913
[Lr] Last revision date:170913
[St] Status:Publisher
[do] DOI:10.1080/14786419.2017.1367785

  5 / 138 MEDLINE  
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[PMID]: 28739601
[Au] Autor:Fialho MFP; Brusco I; da Silva Brum E; Piana M; Boligon AA; Trevisan G; Oliveira SM
[Ad] Address:Neurotoxicity and Psychopharmacology Laboratory, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
[Ti] Title: Lam. crude extract presents antinociceptive effect on an arthritic pain model in mice.
[So] Source:Biochem J;474(17):2993-3010, 2017 Aug 17.
[Is] ISSN:1470-8728
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Arthritis is a chronic inflammatory disease which reduces the life quality of affected individuals. Therapeutic tools used for treating inflammatory pain are associated with several undesirable effects. Lam., known as 'Barbasco' or 'Cambara', is mostly used in several disorders and possesses antirheumatic, anti-inflammatory, and analgesic properties. Here, we investigated the antinociceptive and anti-inflammatory effects of the crude extract applied orally and topically in acute pain models and an arthritic pain model induced by complete Freund's adjuvant (CFA) paw injection in male mice (25-30 g). The high-performance liquid chromatography (HPLC) of the extract crude revealed the presence of the lupeol, stigmasterol, and ß-sitosterol. The stability study of the gel did not show relevant changes at low temperatures. The oral treatment with the extract prevented the capsaicin-induced spontaneous nociception and the acetic acid-induced abdominal writhing, but did not alter the thermal threshold in the tail immersion test. The antinociceptive effect was not reversed by naloxone in the capsaicin test. The oral or topical treatment reversed the CFA-induced mechanical allodynia and thermal hyperalgesia with maximum inhibition ( ) of 69 ± 6 and 68 ± 5% as well as 78 ± 15 and 87 ± 12%, respectively. Moreover, the topical but not oral treatment inhibited the CFA-induced cell infiltration, but did not reduce the paw edema significantly. The oral treatment with did not cause adverse effects. These findings suggest that the oral or topical treatment with presents antinociceptive actions in an arthritic pain model without causing adverse effects.
[Mh] MeSH terms primary: Analgesics, Non-Narcotic/therapeutic use
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
Arthritis, Experimental/drug therapy
Buddleja/chemistry
Plant Extracts/therapeutic use
Plant Leaves/chemistry
[Mh] MeSH terms secundary: Acute Pain/drug therapy
Administration, Cutaneous
Administration, Oral
Analgesics, Non-Narcotic/administration & dosage
Analgesics, Non-Narcotic/adverse effects
Analgesics, Non-Narcotic/chemistry
Animals
Anti-Inflammatory Agents, Non-Steroidal/administration & dosage
Anti-Inflammatory Agents, Non-Steroidal/adverse effects
Anti-Inflammatory Agents, Non-Steroidal/chemistry
Brazil
Buddleja/growth & development
Drug Stability
Drug Storage
Ethnopharmacology
Gels
Hot Temperature/adverse effects
Male
Mice
Pentacyclic Triterpenes/administration & dosage
Pentacyclic Triterpenes/adverse effects
Pentacyclic Triterpenes/analysis
Pentacyclic Triterpenes/therapeutic use
Plant Extracts/administration & dosage
Plant Extracts/adverse effects
Plant Extracts/chemistry
Plant Leaves/growth & development
Sitosterols/administration & dosage
Sitosterols/adverse effects
Sitosterols/analysis
Sitosterols/therapeutic use
Stigmasterol/administration & dosage
Stigmasterol/adverse effects
Stigmasterol/analysis
Stigmasterol/therapeutic use
Viscosity
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Name of substance:0 (Analgesics, Non-Narcotic); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Gels); 0 (Pentacyclic Triterpenes); 0 (Plant Extracts); 0 (Sitosterols); 5LI01C78DD (gamma-sitosterol); 99WUK5D0Y8 (Stigmasterol); O268W13H3O (lupeol)
[Em] Entry month:1708
[Cu] Class update date: 170828
[Lr] Last revision date:170828
[Js] Journal subset:IM
[Da] Date of entry for processing:170726
[St] Status:MEDLINE
[do] DOI:10.1042/BCJ20170008

  6 / 138 MEDLINE  
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[PMID]: 28603107
[Au] Autor:Garza BAA; Arroyo JL; González GG; González EG; González EG; de Torres NW; Aranda RS
[Ad] Address:Departamento de Química Analítica, Facultad de Medicina, Universidad Autónoma de Nuevo León. Madero s/n Col. Mitras Centro. Monterrey, N. L. México.
[Ti] Title:Anti-fungal and Anti-Mycobacterial activity of plants of Nuevo Leon, Mexico.
[So] Source:Pak J Pharm Sci;30(1):17-21, 2017 Jan.
[Is] ISSN:1011-601X
[Cp] Country of publication:Pakistan
[La] Language:eng
[Ab] Abstract:Severe fungal infections, particularly those caused by Candida spp, have increased in recent decades and are associated with an extremely high rate of morbidity and mortality. Since plants are an important source of potentially bioactive compounds, in this work the antifungal activity of the methanol extracts of 10 plants (Acacia rigidula, Buddleja cordata, Cephalanthus occidentalis, Juglans nigra, Parkinsonia aculeata, Parthenium hysterophorus, Quercus canbyi, Ricinus communis, Salvia coccinea and Teucrium bicolor) were evaluated. The activity was evaluated according to the micro dilution assay described in CLSI M27-A protocol using some clinical isolates of different species of Candida (C. albicans, C. parapsilosis, C. tropicalis, C. krusei and C. glabrata). All extracts showed MIC values < 31.25µg/mL against at least one of the strains used, which is very interesting because it was crude extracts. Acacia rigidula (0.93-3.75µg/mL) and Quercus canbyi (0.93-7.5µg/mL) had antifungal activity against 7 strains with MIC values <8µg/mL in all cases. Furthermore excerpts activity against Mycobacterium tuberculosis (strain H37rv) was evaluated. Only Salvia coccinea and Teucrium bicolor showed MIC values125µg/mL by the method of MABA.
[Mh] MeSH terms primary: Anti-Bacterial Agents/pharmacology
Antifungal Agents/pharmacology
Candida/drug effects
Mycobacterium tuberculosis/drug effects
Plant Extracts/pharmacology
Plants, Medicinal/chemistry
[Mh] MeSH terms secundary: Anti-Bacterial Agents/isolation & purification
Antifungal Agents/isolation & purification
Candida/growth & development
Methanol/chemistry
Mexico
Microbial Sensitivity Tests
Mycobacterium tuberculosis/growth & development
Phytotherapy
Plant Extracts/isolation & purification
Solvents/chemistry
[Pt] Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Plant Extracts); 0 (Solvents); Y4S76JWI15 (Methanol)
[Em] Entry month:1711
[Cu] Class update date: 171103
[Lr] Last revision date:171103
[Js] Journal subset:IM
[Da] Date of entry for processing:170613
[St] Status:MEDLINE

  7 / 138 MEDLINE  
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[PMID]: 28421562
[Au] Autor:El-Ganiny AM; Shaker GH; Aboelazm AA; El-Dash HA
[Ad] Address:Microbiology and Immunology Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt. amiraganiny@yahoo.com.
[Ti] Title:Prevention of Bacterial Biofilm Formation on Soft Contact Lenses Using Natural Compounds.
[So] Source:J Ophthalmic Inflamm Infect;7(1):11, 2017 Dec.
[Is] ISSN:1869-5760
[Cp] Country of publication:Germany
[La] Language:eng
[Ab] Abstract:PURPOSE: In eye care field, contact lenses (CL) have a great impact on improving vision, but their use can be limited by ocular infection. CL- associated infections can be reduced by good attention to CL storage case practice. CL-care solutions should be able to control microbial growth on CL. The aim of the study was to evaluate and compare the efficacy of CL-care solutions (found in Egyptian market) with some natural compounds in removal and inhibition of bacterial biofilm formed on soft CL. Clinical isolates were recovered from patients having conjunctivitis from Benha University Hospital and identified microbiologically. Quantification of biofilm was done using microtiter plate assay. Three multipurpose CL-care solutions were examined for their ability to remove and inhibit biofilm. Also four natural extracts having antibacterial activity and are safe on eye were tested for their anti-biofilm activity. RESULTS: The major bacterial isolates from eye infections were Pseudomonas aeruginosa (36%) and Staphylococcus spp. (37.8%). Only 33.3% of isolates showed ability to produce weak to moderate biofilm. The tested multi-purpose CL-care solutions showed moderate ability to remove preformed biofilm. Among the tested natural compounds, Calendula officinalis and Buddleja salviifolia extracts showed an excellent efficacy in inhibition of biofilm and also removal of preformed biofilm. CONCLUSION: This study demonstrated that isolates from infected eye and CL-cases showed weak to moderate biofilm formation. Calendula officinalis and Buddleja salviifolia extracts showed excellent effect on inhibition and removal of biofilm, these extracts could be added into CL-care solutions which could markedly reduce eye-infections during CL-wear.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1704
[Cu] Class update date: 170816
[Lr] Last revision date:170816
[St] Status:PubMed-not-MEDLINE
[do] DOI:10.1186/s12348-017-0129-0

  8 / 138 MEDLINE  
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[PMID]: 28386629
[Au] Autor:Suwalsky M; Duguet J; Speisky H
[Ad] Address:Faculty of Chemical Sciences, University of Concepción, Concepción, Chile. msuwalsk@udec.cl.
[Ti] Title:An In Vitro Study of the Antioxidant and Antihemolytic Properties of Buddleja globosa (Matico).
[So] Source:J Membr Biol;250(3):239-248, 2017 Jun.
[Is] ISSN:1432-1424
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The antioxidant and antihemolytic properties contained in the leaves of Buddleja globosa (B. globosa), also known as "Matico," were determined. Aqueous extracts of leaves were assayed in human erythrocytes and molecular models of its membrane. The latter were bilayers built-up of lipids located in the outer and inner leaflets of the erythrocyte membrane. Observations by scanning electron microscopy showed that the extract altered the morphology of erythrocytes inducing the formation of crenated echinocytes. This result implied that the extract components were inserted into the outer leaflet of the cell membrane. This conclusion was confirmed by experiments carried out by fluorescence spectroscopy of red cell membranes and vesicles (LUV) of dimyristoylphosphatidylcholine (DMPC) and by X-ray diffraction of DMPC and dimyristoylphosphatidylethanolamine bilayers. Human erythrocytes were in vitro exposed to HClO, which is a natural powerful oxidant. Results demonstrated that low concentrations of B. globosa aqueous extract neutralized the harmful capacity of HClO. Hemolysis experiments also showed that the extract in very low concentrations reduced hemolysis induced by HClO.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1704
[Cu] Class update date: 170922
[Lr] Last revision date:170922
[St] Status:In-Process
[do] DOI:10.1007/s00232-017-9955-0

  9 / 138 MEDLINE  
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[PMID]: 28278765
[Au] Autor:Singh A; Venugopala KN; Khedr MA; Pillay M; Nwaeze KU; Coovadia Y; Shode F; Odhav B
[Ad] Address:a Department of Biotechnology and Food Technology , Durban University of Technology , Durban 4001 , South Africa.
[Ti] Title:Antimycobacterial, docking and molecular dynamic studies of pentacyclic triterpenes from Buddleja saligna leaves.
[So] Source:J Biomol Struct Dyn;35(12):2654-2664, 2017 Sep.
[Is] ISSN:1538-0254
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Buddleja saligna (family Buddlejaceae) is a medicinal plant endemic to South Africa. Two isomeric pentacyclic triterpenes, oleanolic acid and ursolic acid, were isolated from the leaves of B. saligna using silica gel column chromatography. Compounds oleanolic acid and ursolic acid were subjected to derivatization with acetic anhydride in the presence of pyridine to obtain oleanolic acid-3-acetate and ursolic acid-3-acetate, respectively. The structures of these compounds were fully characterized by detailed nuclear magnetic resonance (NMR) investigations, which included H and C NMR. Molecular docking studies predicted the free binding energy of the four triterpenes inside the steroid binding pocket of Mycobacterium tuberculosis fadA5 thiolase compared to a reported inhibitor. Thus, their ability to inhibit the growth of M. tuberculosis was predicted and was confirmed to possess significant antimycobacterial activity when tested against Mycobacterium smegmatis, M. tuberculosis H Rv (ATCC 25177), clinical isolates of multi-drug-resistant M. tuberculosis (MDR-TB) and extensively drug-resistant M. tuberculosis (XDR-TB) using the Micro Alamar Blue Assay. Ursolic acid was isolated from this plant for the first time.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1703
[Cu] Class update date: 170807
[Lr] Last revision date:170807
[St] Status:In-Process
[do] DOI:10.1080/07391102.2016.1227725

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[PMID]: 27943550
[Au] Autor:Pellegrini MC; Alonso-Salces RM; Umpierrez ML; Rossini C; Fuselli SR
[Ad] Address:Grupo de Investigación Microbiología Aplicada, Departamento de Biología, Centro de Investigación en Abejas Sociales, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Funes 3350, 7600, Mar del Plata, Argentina.
[Ti] Title:Chemical Composition, Antimicrobial Activity, and Mode of Action of Essential Oils against Paenibacillus larvae, Etiological Agent of American Foulbrood on Apis mellifera.
[So] Source:Chem Biodivers;14(4), 2017 Apr.
[Is] ISSN:1612-1880
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:This study aimed to characterize the chemical composition of Aloysia polystachia, Acantholippia seriphioides, Schinus molle, Solidago chilensis, Lippia turbinata, Minthostachys mollis, Buddleja globosa, and Baccharis latifolia essential oils (EOs), and to evaluate their antibacterial activities and their capacity to provoke membrane disruption in Paenibacillus larvae, the bacteria that causes the American Foulbrood (AFB) disease on honey bee larvae. The relationship between the composition of the EOs and these activities on P. larvae was also analyzed. Monoterpenes were the most abundant compounds in all EOs. All EOs showed antimicrobial activity against P. larvae and disrupted the cell wall and cytoplasmic membrane of P. larvae provoking the leakage of cytoplasmic constituents (with the exception of B. latifolia EO). While, the EOs' antimicrobial activity was correlated most strongly to the content of pulegone, carvone, (Z)-ß-ocimene, δ-cadinene, camphene, terpinen-4-ol, elemol, ß-pinene, ß-elemene, γ-cadinene, α-terpineol, and bornyl acetate; the volatiles that better explained the membrane disruption were carvone, limonene, cis-carvone oxide, pentadecane, trans-carvyl acetate, trans-carvone oxide, trans-limonene oxide, artemisia ketone, trans-carveol, thymol, and γ-terpinene (positively correlated) and biciclogermacrene, δ-2-carene, verbenol, α-pinene, and α-thujene (negatively correlated). The studied EOs are proposed as natural alternative means of control for the AFB disease.
[Mh] MeSH terms primary: Anti-Bacterial Agents/isolation & purification
Bees/microbiology
Oils, Volatile/pharmacology
Paenibacillus larvae/drug effects
[Mh] MeSH terms secundary: Animals
Anti-Bacterial Agents/pharmacology
Bees/drug effects
Cell Membrane/drug effects
Cell Membrane Permeability/drug effects
Oils, Volatile/chemistry
Plant Extracts/chemistry
Plant Extracts/pharmacology
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Anti-Bacterial Agents); 0 (Oils, Volatile); 0 (Plant Extracts)
[Em] Entry month:1704
[Cu] Class update date: 170424
[Lr] Last revision date:170424
[Js] Journal subset:IM
[Da] Date of entry for processing:161213
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600382


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