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[PMID]: 29454264
[Au] Autor:Rashid M; Singh SK; Malik MY; Jahan S; Chaturvedi S; Taneja I; Raju KS; Naseem Z; Gayen JR; Wahajuddin M
[Ad] Address:Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India.
[Ti] Title:Development and validation of UPLC-MS/MS assay for quantification of cladrin: Absolute bioavailability and dose proportionality study in rats.
[So] Source:J Pharm Biomed Anal;152:289-297, 2018 Apr 15.
[Is] ISSN:1873-264X
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Cladrin, an isoflavone is a major bioactive constituent found in stem bark of Butea monosperma with remarkable osteogenic activity. A speedy and sensitive UPLC coupled tandem mass spectrometry (UPLC-MS/MS) method was developed, validated and successfully applied to bioavailability, blood partitioning, plasma protein binding, intravenous and multiple-dose oral pharmacokinetics of cladrin in rats. Separation was done on C18 column (5.0 µm, 4.6 × 50 mm) using mobile phase containing acetonitrile and 0.10% formic acid in the ratio of 65:35 (v/v) with 0.60 mL/min flow rate. The method was highly sensitive and has a short run time of 2.50 min with an excellent linearity (R > 0.99) in the range of 0.20-200 µg/L. Absolute bioavailability was found to be 16.58, 19.04 and 6.76% at oral doses of 5, 10, and 20 mg/Kg, respectively. Cladrin was rapidly absorbed (T 3.0 h) with a high apparent volume of distribution (15.03 ±â€¯1.79L/Kg), high clearance (2.27 ±â€¯0.30L/h/Kg) and high plasma protein binding. The present study is a first comprehensive in-vitro as well as the in-vivo preclinical pharmacokinetic report of cladrin giving insights about its drug-likeness and further development as a potential therapeutic agent.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1802
[Cu] Class update date: 180304
[Lr] Last revision date:180304
[St] Status:In-Process

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[PMID]: 29366766
[Au] Autor:Karia P; Patel KV; Rathod SSP
[Ad] Address:Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara 390001, Gujarat, India. Electronic address: prachidk@gmail.com.
[Ti] Title:Breast cancer amelioration by Butea monosperma in-vitro and in-vivo.
[So] Source:J Ethnopharmacol;217:54-62, 2018 Jan 31.
[Is] ISSN:1872-7573
[Cp] Country of publication:Ireland
[La] Language:eng
[Ab] Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: Butea monosperma belonging to family Fabaceae is used in the Indian traditional medicine (Ayurveda) for various ailments including abdominal tumors and possess anti-estrogenic activity. AIM OF THE STUDY: The present study is aimed at investigating the chemo-preventive potential of Butea monosperma in breast cancer and elucidating it's mechanism of action by assessing its effect on key processes like apoptosis, angiogenesis and metastasis. METHODS: Cytotoxic potential of methanol extract of Butea monosperma flower (MEBM) was tested in MCF-7 (estrogen receptor positive), MDA-MB-231 (triple negative) and MDA-MB-453 (HER2 positive) human breast cancer cells by MTT assay. Chemo-preventive potential was evaluated in-vivo in Methylnitrosourea (MNU) induced mammary cancer in nulliparous Sprague-Dawley rats. The mechanism for anticancer potential was screened by in-vitro studies involving Annexin V- FITC assay (apoptosis), Chick Chorioallantoic Membrane assay (angiogenesis) and Migration assay (metastasis). Statistical analysis was done by one way and two way ANOVA (for Growth Rate and feed consumption efficiency) followed by post hoc Bonferroni's test with P value < 0.05. RESULTS: It is observed that the exposure of MEBM, at various concentrations and time intervals to different cell lines, resulted in decreased cell proliferation. The IC value of MCF-7 cells was found significantly less than that of MDA-MB-231 and MDA-MB-453 cells, which indicated that the extract of said medicinal plant were more potent inhibitors of estrogen positive breast cancer cells than other types of breast cancer cells in vitro. Corroborative evidences were acquired in MNU actuated mammary carcinogenesis where MEBM constricted tumor parameters, decreased expression of estrogen and progesterone, nucleic acid content and increased latency period. MEBM also induced apoptosis, inhibited angiogenesis and metastasis in-vitro. CONCLUSION: Selective cytotoxic activity in MCF-7 estrogen positive breast cancer cells and inhibition of growth of mammary carcinoma in-vivo by methanol extract of Butea monosperma flowers (MEBM) suggests chemo-prevention through modulation of estrogen and progesterone receptor, apoptotic, anti-angiogenesis and anti-metastatic activity.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1801
[Cu] Class update date: 180303
[Lr] Last revision date:180303
[St] Status:Publisher

  3 / 155 MEDLINE  
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[PMID]: 28987943
[Au] Autor:Ansari MY; Khan NM; Haqqi TM
[Ad] Address:Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
[Ti] Title:A standardized extract of Butea monosperma (Lam.) flowers suppresses the IL-1ß-induced expression of IL-6 and matrix-metalloproteases by activating autophagy in human osteoarthritis chondrocytes.
[So] Source:Biomed Pharmacother;96:198-207, 2017 Oct 04.
[Is] ISSN:1950-6007
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:BACKGROUND/OBJECTIVE: Osteoarthritis (OA) is a leading cause of joint dysfunction, disability and poor quality of life in the affected population. The underlying mechanism of joint dysfunction involves increased oxidative stress, inflammation, high levels of cartilage extracellular matrix degrading proteases and decline in autophagy-a mechanism of cellular defense. There is no disease modifying therapies currently available for OA. Different parts of the Butea monosperma (Lam.) plant have widely been used in the traditional Indian Ayurvedic medicine system for the treatment of various human diseases including inflammatory conditions. Here we studied the chondroprotective effect of hydromethanolic extract of Butea monosperma (Lam.) flowers (BME) standardized to the concentration of Butein on human OA chondrocytes stimulated with IL-1ß. METHODS: The hydromethanolic extract of Butea monosperma (Lam.) (BME) was prepared with 70% methanol-water mixer using Soxhlet. Chondrocytes viability after BME treatment was measured by MTT assay. Gene expression levels were determined by quantitative polymerase chain reaction (qPCR) using TaqMan assays and immunoblotting with specific antibodies. Autophagy activation was determined by measuring the levels of microtubule associated protein 1 light chain 3-II (LC3-II) by immunoblotting and visualization of autophagosomes by transmission electron and confocal microscopy. RESULTS: BME was non-toxic to the OA chondrocytes at the doses employed and suppressed the IL-1ß induced expression of inerleukin-6 (IL-6) and matrix metalloprotease-3 (MMP-3), MMP-9 and MMP-13. BME enhanced autophagy in chondrocytes as determined by measuring the levels of LC3-II by immunoblotting and increased number of autophagosomes in BME treated chondrocytes by transmission electron microscopy and confocal microscopy. BME upregulated the expression of several autophagy related genes and increased the autophagy flux in human OA chondrocytes under pathological conditions. Further analysis revealed that BME activated autophagy in chondrocytes via inhibition of mammalian target of rapamycin (mTOR) pathway. Of importance is our finding that BME-mediated suppression of IL-1ß induced expression of IL-6, MMP-3, -9, and -13 was autophagy dependent and was abrogated by inhibition of autophagy. CONCLUSION: The above results show that the Butea monosperma (Lam.) extract has strong potential to activate autophagy and suppress IL-1ß induced expression of IL-6 and MMP-3, -9 and -13 in human OA chondrocytes. This study shows that BME or compounds derived from BME can be developed as safe and effective chondroprotective agent(s) that function by activating autophagy to suppress the expression of inflammatory and catabolic factors associated with OA pathogenesis.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1710
[Cu] Class update date: 171008
[Lr] Last revision date:171008
[St] Status:Publisher

  4 / 155 MEDLINE  
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[PMID]: 28390310
[Au] Autor:Subramaniyan B; Kumar V; Mathan G
[Ad] Address:Department of Biomedical Science, School of Basic Medical Science, Bharathidasan University, Tiruchirappalli, 620 024 Tamilnadu, India.
[Ti] Title:Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated apoptosis in colorectal cancer cells.
[So] Source:Biomed Pharmacother;90:402-413, 2017 Jun.
[Is] ISSN:1950-6007
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:The infrequent manifestation of SIRT1 and Aurora B kinase has shown to play a pivotal role in colorectal cancer (CRC) progression by regulating Wnt signaling pathway. The present study investigates the signaling events that regulate the modulation of SIRT1 and Aurora B kinase expression and it's mediated cell proliferation in SW480 human primary adenocarcinoma CRC cells using Butea monosperma floral compounds (BMFC). In this, cell viability, mitochondrial mediated apoptosis, cell cycle arrest and inhibition of Wnt pathway were examined. Interestingly, the active novel compound, sodium salt of butrin, from BMFC significantly enhances the apoptosis activity, where SIRT1 and Aurora B kinase were ectopically overexpressed in CRC cells. Moreover, mRNA and protein expressions analysis indicates that the expression of GSK-3ß, ß-catenin, cyclin D1, pAKT, TGF-3ß, SIRT1 and Aurora B kinase were down regulated in BMFC treated cells. These findings provide valuable information that the active BMFC having great impact on SIRT1 and Aurora B kinase mediated Wnt signaling down regulation in SW480 CRC cells.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1704
[Cu] Class update date: 170509
[Lr] Last revision date:170509
[St] Status:In-Process

  5 / 155 MEDLINE  
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[PMID]: 28374446
[Au] Autor:Boonsombat J; Prachyawarakorn V; Pansanit A; Mahidol C; Ruchirawat S; Thongnest S
[Ad] Address:Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok, 10210, Thailand.
[Ti] Title:Superbanone, A New 2-Aryl-3-benzofuranone and Other Bioactive Constituents from the Tube Roots of Butea superba.
[So] Source:Chem Biodivers;14(7), 2017 Jul.
[Is] ISSN:1612-1880
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:Phytochemical investigation from the tube roots of Butea superba, led to the isolation and identification of a new 2-aryl-3-benzofuranone named superbanone (1), one benzoin, 2-hydroxy-1-(2-hydroxy-4-methoxyphenyl)-2-(4-methoxyphenyl)ethanone (2), eight pterocarpans (3 - 10), and eleven isoflavonoids (11 - 21). Compound 2 was identified for the first time as a natural product. The structure of the isolated compounds was elucidated using spectroscopic methods, mainly 1D- and 2D-NMR. The isolated compounds and their derivatives were evaluated for α-glucosidase inhibitory and antimalarial activities. Compounds 3, 7, 8, and 11 showed promising α-glucosidase inhibitory activity (IC  = 13.71 ± 0.54, 23.54 ± 0.75, 28.83 ± 1.02, and 12.35 ± 0.36 µm, respectively). Compounds 3 and 11 were twofold less active than the standard drug acarbose (IC  = 6.54 ± 0.04 µm). None of the tested compounds was found to be active against Plasmodium falciparum strain 94. On the basis of biological activity results, structure-activity relationships are discussed.
[Mh] MeSH terms primary: Antimalarials/isolation & purification
Benzofurans/isolation & purification
Butea/chemistry
Glycoside Hydrolase Inhibitors/isolation & purification
[Mh] MeSH terms secundary: Antimalarials/chemistry
Antimalarials/pharmacology
Benzofurans/pharmacology
Benzoin/isolation & purification
Flavonoids/isolation & purification
Glycoside Hydrolase Inhibitors/chemistry
Glycoside Hydrolase Inhibitors/pharmacology
Plant Roots/chemistry
Plasmodium falciparum/drug effects
Pterocarpans/isolation & purification
Structure-Activity Relationship
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antimalarials); 0 (Benzofurans); 0 (Flavonoids); 0 (Glycoside Hydrolase Inhibitors); 0 (Pterocarpans); L7J6A1NE81 (Benzoin)
[Em] Entry month:1709
[Cu] Class update date: 170922
[Lr] Last revision date:170922
[Js] Journal subset:IM
[Da] Date of entry for processing:170405
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201700044

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[PMID]: 28367764
[Au] Autor:Gautam J; Khedgikar V; Kushwaha P; Choudhary D; Nagar GK; Dev K; Dixit P; Singh D; Maurya R; Trivedi R
[Ad] Address:1Endocrinology Division,CSIR-Central Drug Research Institute,Lucknow 226031,India.
[Ti] Title:Formononetin, an isoflavone, activates AMP-activated protein kinase/ß-catenin signalling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss.
[So] Source:Br J Nutr;117(5):645-661, 2017 Mar.
[Is] ISSN:1475-2662
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Balance between adipocyte and osteoblast differentiation is the key link of disease progression in obesity and osteoporosis. We have previously reported that formononetin (FNT), an isoflavone extracted from Butea monosperma, stimulates osteoblast formation and protects against postmenopausal bone loss. The inverse relationship between osteoblasts and adipocytes prompted us to analyse the effect of FNT on adipogenesis and in vivo bone loss, triggered by high-fat diet (HFD)-induced obesity. The anti-obesity effect and mechanism of action of FNT was determined in 3T3-L1 cells and HFD-induced obese male mice. Our findings show that FNT suppresses the adipogenic differentiation of 3T3-L1 fibroblasts, through down-regulation of key adipogenic markers such as PPARγ, CCAAT/enhancer-binding protein alpha (C/EBPα) and sterol regulatory element-binding protein (SREBP) and inhibits intracellular TAG accumulation. Increased intracellular reactive oxygen species levels and AMP-activated protein kinase (AMPK) activation accompanied by stabilisation of ß-catenin were attributed to the anti-adipogenic action of FNT. In vivo, 12 weeks of FNT treatment inhibited the development of obesity in mice by attenuating HFD-induced body weight gain and visceral fat accumulation. The anti-obesity effect of FNT results from increased energy expenditure. FNT also protects against HFD-induced dyslipidaemia and rescues deterioration of trabecular bone volume by increasing bone formation and decreasing bone resorbtion caused by HFD. FNT's rescuing action against obesity-induced osteoporosis commenced at the level of progenitors, as bone marrow progenitor cells, obtained from the HFD mice group supplemented with FNT, showed increased osteogenic and decreased adipogenic potentials. Our findings suggest that FNT inhibits adipogenesis through AMPK/ß-catenin signal transduction pathways and protects against HFD-induced obesity and bone loss.
[Mh] MeSH terms primary: AMP-Activated Protein Kinases/metabolism
Adipogenesis/drug effects
Isoflavones/pharmacology
Obesity/prevention & control
Osteoporosis/prevention & control
beta Catenin/metabolism
[Mh] MeSH terms secundary: 3T3-L1 Cells
Adipocytes/drug effects
Adipocytes/metabolism
Animals
Bone Marrow Cells/cytology
Bone Marrow Cells/metabolism
Bone Resorption/drug therapy
Cell Differentiation/drug effects
Diet, High-Fat/adverse effects
Disease Models, Animal
Energy Metabolism/drug effects
Male
Mice
Mice, Inbred C57BL
Obesity/etiology
Osteoporosis/etiology
Reactive Oxygen Species/metabolism
Signal Transduction/drug effects
Uncoupling Protein 1/genetics
Up-Regulation/drug effects
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Isoflavones); 0 (Reactive Oxygen Species); 0 (Uncoupling Protein 1); 0 (beta Catenin); 295DQC67BJ (formononetin); EC 2.7.11.31 (AMP-Activated Protein Kinases)
[Em] Entry month:1704
[Cu] Class update date: 171116
[Lr] Last revision date:171116
[Js] Journal subset:IM
[Da] Date of entry for processing:170404
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517000149

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[PMID]: 28237915
[Au] Autor:Kaur V; Kumar M; Kaur P; Kaur S; Singh AP; Kaur S
[Ad] Address:Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar 143005, Punjab, India.
[Ti] Title:Hepatoprotective activity of Butea monosperma bark against thioacetamide-induced liver injury in rats.
[So] Source:Biomed Pharmacother;89:332-341, 2017 May.
[Is] ISSN:1950-6007
[Cp] Country of publication:France
[La] Language:eng
[Ab] Abstract:For thousands of years, the plant-based natural products have been a source of curative agents for various ailments. Butea monosperma (Fabaceae) has an important place in Indian traditional system of medicine for curing number of disorders. The present study deals with evaluation of hepatoprotective properties of ethyl acetate fraction (Beac) from B. monosperma bark in rat model. In preliminary antioxidant studies, Beac demonstrated pronounced superoxide scavenging (IC 88.85µg/ml) and anti-lipid peroxidation (IC 131.66µg/ml) potential. In animal studies, Beac showed protective effect against thioacetamide-induced pathophysiology in liver of male Wistar rats. The levels of different parameters related to hepatic functions were altered by thioacetamide treatment (300mg/g bw) in rats. The pre-treatment of rats with Beac (50, 100 and 200mg/kg bw) was able to normalize the biochemical markers viz. serum bilirubin, SGOT, SGPT, albumin and ALP along with liver antioxidative molecules viz. SOD, CAT, GSH and GR. Results of histopathological and colorimetric studies revealed that Beac treatment also restored the markers of fibrosis i.e. collagen and hydroxyproline towards normal level. Beac considerably inhibited thioacetamide-induced expression of p-PI3K, p-Akt and p-mTOR in hepatocytes as revealed from immunohistochemical studies. This finding is the first evidence of inhibitory action of B. monosperma bark on these pro-carcinogenic proteins. HRMS analysis revealed the presence of quercetin, buteaspermin B and ononin in Beac fraction of Butea monosperma. From the results, it can be concluded that B. monosperma bark is a rich source of phytochemicals with in vitro and in vivo protective activities which deserves further mechanistic studies for its use as a hepatoprotective agent in the prevention of hepatic inflammation and its related malignancies.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1702
[Cu] Class update date: 170429
[Lr] Last revision date:170429
[St] Status:In-Process

  8 / 155 MEDLINE  
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[PMID]: 28207992
[Au] Autor:Kaur V; Kumar M; Kaur P; Kaur S; Kaur S
[Ad] Address:Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.
[Ti] Title:Inhibitory Activities of Butanol Fraction from Butea monosperma (Lam.) Taub. Bark Against Free Radicals, Genotoxins and Cancer Cells.
[So] Source:Chem Biodivers;14(6), 2017 Jun.
[Is] ISSN:1612-1880
[Cp] Country of publication:Switzerland
[La] Language:eng
[Ab] Abstract:The present study was undertaken to investigate antioxidant, antigenotoxic, and antiproliferative activity of butanol fraction (Bmbu) from bark of medicinal plant Butea monosperma. Antioxidant potency of Bmbu was examined by various in vitro assays. It was also investigated for antigenotoxic activity using Escherichia coli. PQ37 employing SOS chromotest. Further, cytotoxic and apoptosis inducing activity of Bmbu was evaluated in MCF-7 breast cancer cells. Bmbu showed potent free radical scavenging ability in ABTS assay (IC 56.70 µg/ml) and anti-lipid peroxidation ability (IC 40.39 µg/ml). 4NQO and H O induced genotoxicity was suppressed by Bmbu in SOS chromotest by 74.26% and 82.02% respectively. It also inhibited the growth of MCF-7 cells with GI value of 158.71 µg/ml. Induction of apoptosis in MCF-7 cells by Bmbu treatment was deciphered using confocal microscopy, flow cytometry, and neutral comet assay. Bmbu treatment increased cell population in sub-G phase (69.6%) indicating apoptotic cells. Further, Bmbu treatment resulted in increased reactive oxygen species generation and decreased mitochondrial membrane potential indicating involvement of mitochondrial dependent pathway of apoptosis. HPLC profiling showed the presence of polyphenols such as ellagic acid, catechin, quercetin, and gallic acid as its major constituents. Consequently, it is suggested that the phytoconstituents from this plant may be further exploited for development of novel drug formulation with possible therapeutic implication.
[Mh] MeSH terms primary: Antimutagenic Agents/isolation & purification
Antineoplastic Agents, Phytogenic/isolation & purification
Antioxidants/isolation & purification
Butea/chemistry
Plant Extracts/chemistry
[Mh] MeSH terms secundary: Antimutagenic Agents/pharmacology
Antineoplastic Agents, Phytogenic/pharmacology
Antioxidants/pharmacology
Apoptosis/drug effects
Butanols
Cell Proliferation/drug effects
Humans
Lipid Peroxidation/drug effects
MCF-7 Cells
Plant Bark/chemistry
Plants, Medicinal/chemistry
Polyphenols/analysis
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Antimutagenic Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Butanols); 0 (Plant Extracts); 0 (Polyphenols)
[Em] Entry month:1708
[Cu] Class update date: 170822
[Lr] Last revision date:170822
[Js] Journal subset:IM
[Da] Date of entry for processing:170217
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600484

  9 / 155 MEDLINE  
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[PMID]: 28163055
[Au] Autor:Khan W; Gupta S; Ahmad S
[Ad] Address:Bioactive Natural Product Laboratory, Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India.
[Ti] Title:Toxicology of the aqueous extract from the flowers of Butea monosperma Lam. and it's metabolomics in yeast cells.
[So] Source:Food Chem Toxicol;108(Pt B):486-497, 2017 Oct.
[Is] ISSN:1873-6351
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Due to lack of scientific evidence for the safety of Butea monosperma (Fabaceae), our study aimed to carry out its toxicological profile and to identify its metabolic pattern in yeast cell. The effect of aqueous extract of B. monosperma flower on glucose uptake in yeast cell was evaluated through optimizing pH, temperature, incubation time, substrate concentration and kinetic parameters. Further, the metabolic pattern of extract as such and in yeast cell were analyzed by gas chromatography-mass spectrometry. Mice were administered aqueous extract up to 6000 and 4000 mg/kg for acute oral and intraperitoneal toxicity, respectively, while up to 4500 mg/kg for sub-acute oral toxicity (30 days). Elongation in the lag and log phase was observed in yeast cells supplemented with extract as compared to control. A maximum of 184.9% glucose uptake was observed whereas kinetic parameters (K and V ) were 1.38 and 41.91 mol/s, respectively. Out of 75 metabolites found in the extract, 14 and 18 metabolites were utilized by yeast cell after 15 and 30 min of incubation, respectively. The LD of extract administered through intraperitoneal route was estimated to be 3500 mg/kg. The extract did not elicit any significant difference (P ≥ 0.05) in weight gain, food consumption, water intake, hematological, biochemical parameters and histological changes as compared to the normal control. Results ascertained the safety of B. monosperma flower extract which can be explored as potential candidates for the development of anti-diabetic phytopharmaceuticals.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1702
[Cu] Class update date: 170923
[Lr] Last revision date:170923
[St] Status:In-Process

  10 / 155 MEDLINE  
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[PMID]: 27125688
[Au] Autor:Eumkeb G; Tanphonkrang S; Sirichaiwetchakoon K; Hengpratom T; Naknarong W
[Ad] Address:a School of Pharmacology, Institute of Science , Suranaree University of Technology , Nakhon Ratchasima , Thailand.
[Ti] Title:The synergy effect of daidzein and genistein isolated from Butea superba Roxb. on the reproductive system of male mice.
[So] Source:Nat Prod Res;31(6):672-675, 2017 Mar.
[Is] ISSN:1478-6427
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Butea superba Roxb. (BS) has been used in Thai men as an aphrodisiac, and prevent erectile dysfunction. Nevertheless, the active ingredients, dosages, have not been cleared. Hence, this study was to investigate the effect of compounds from the BS on the reproductive parameters of male mice. The results revealed that BS was extracted to afford biochanin A and genistein, which were first reported on BS, and daidzein. The mice were treated by daidzein and genistein alone and in combination. The results showed that the sperm number and motility, cholesterol and testosterone level of all isoflavones-treated groups were significantly higher than controls (p < 0.01). Obviously, daidzein plus genistein exhibited a synergistic effect, which is also the first report, and resulted in significantly displayed higher levels of these parameters compared to others. So, the synergistic activity of these isoflavones may be useful in improving libido, erectile capacity and assist infertility of poor spermatozoa in men.
[Mh] MeSH terms primary: Butea/chemistry
Estrogens, Non-Steroidal/pharmacology
Genistein/pharmacology
Genitalia, Male/drug effects
Isoflavones/pharmacology
[Mh] MeSH terms secundary: Animals
Body Weight/drug effects
Cholesterol/metabolism
Drug Synergism
Male
Mice
Organ Size/drug effects
Plant Roots/chemistry
Sperm Count
Sperm Motility/drug effects
Spermatozoa/chemistry
Spermatozoa/drug effects
Spermatozoa/ultrastructure
Testosterone/metabolism
[Pt] Publication type:JOURNAL ARTICLE
[Nm] Name of substance:0 (Estrogens, Non-Steroidal); 0 (Isoflavones); 3XMK78S47O (Testosterone); 6287WC5J2L (daidzein); 97C5T2UQ7J (Cholesterol); DH2M523P0H (Genistein)
[Em] Entry month:1704
[Cu] Class update date: 170817
[Lr] Last revision date:170817
[Js] Journal subset:IM
[Da] Date of entry for processing:160430
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1180603


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