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[PMID]: 25778134
[Au] Autor:Ballotari P; Caroli S; Ferrari F; Romani G; Marina G; Chiarenza A; Manicardi V; Giorgi Rossi P
[Ad] Address:Servizio Interaziendale di Epidemiologia, Local Health Authority, Via Amendola 2, Reggio Emilia, Italy, paola.ballotari@ausl.re.it.
[Ti] Title:Differences in diabetes prevalence and inequalities in disease management and glycaemic control by immigrant status: a population-based study (Italy).
[So] Source:BMC Public Health;15:1403, 2015 Dec.
[Is] ISSN:1471-2458
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: The diabetes prevalence increases at an alarming rate around the world and understanding disparities in occurrence, care management, and health outcomes may be a starting point towards achieving more effective strategies to prevent and manage it. The aims of this study are to compare immigrants and Italians in terms of the differences in diabetes prevalence and to evaluate inequalities in disease management and glycaemic control by using information included in Reggio Emilia diabetes register. METHODS: We retrieved from the diabetes register subjects aged 20-74 on December 31(st), 2009. Using citizenship, we created three main groups: Italy, High Developed Countries (HDC), and High Migration Pressure Countries (HMPC). These were split into sub-regions of origin. We calculated age-adjusted prevalence by gender and sub-region. Using logistic regression model, we analyzed the association between area of origin and following indicators: 1) not being in care of diabetes clinics; 2) not having glycated haemoglobin (HbA1c) test in 2010; 3) among those tested, having a HbA1c value > = 9% (75 mmol/mol). RESULTS: We found 15,889 Italian and 1,295 HMPC citizens with diabetes. HMPC citizens had higher age-adjusted prevalence of diabetes than Italians (females 5.0% vs 3.6%; males 6.5% vs 5.5%). The excess was mostly due to a strong excess in immigrants from Southern Asia (females 9.7%, males 10.2%) and Northern Africa (females 9.3%, males 5.9%). HMPC citizens were cared for by diabetes clinics in a similar proportion than Italians (OR: 1.08; 95% CI: 0.93-1.25), but had a greater odds of not being tested for HbA1c (OR: 1.51; 95% CI: 1.34-1.71), as well as of having HbA1c values equal to or over 9% (OR: 2.06; 95% CI: 1.80-3.14). The outcomes were poorer in HMPC females for the first two outcomes, while there was no difference for the HbA1c values (Wald test for heterogeneity p = 0.0850; p = 0.0156; p = 0.6635, respectively). CONCLUSIONS: Our findings highlight the need for gender-oriented actions for prevention and early diagnosis of the diabetes to contrast the higher risk in Northern Africans and Southern Asians. Further studies are required to determine whether the protocols in use are adequate for different immigrant groups.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150319
[Lr] Last revision date:150319
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1186/s12889-015-1403-4

  2 / 1222 MEDLINE  
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[PMID]: 24787379
[Au] Autor:Rossi PG; Caroli S; Mancini S; de' Bianchi PS; Finarelli AC; Naldoni C; Bucchi L; Falcini F; Emilia-Romagna cervical cancer screening and pathology registry group
[Ad] Address:aInterinstitutional Epidemiology Unit, Local Health Authority and IRCCS Arcispedale Santa Maria Nuova, Reggio Emilia bRomagna Cancer Registry, Romagna Cancer Research and Care Institute (IRST) s.r.l., IRCCS, Meldola (FC) cPublic Health Unit, Health Regional Authority, Emilia-Romagna Region, Bologna, Italy.
[Ti] Title:Screening history of cervical cancers in Emilia-Romagna, Italy: defining priorities to improve cervical cancer screening.
[So] Source:Eur J Cancer Prev;24(2):128-34, 2015 Mar.
[Is] ISSN:1473-5709
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:Most invasive cervical cancers in industrialized countries are due to the lack of Pap test coverage, very few are due to screening failures. This study aimed at quantifying the proportion of invasive cancers occurring in nonscreened or underscreened women and that in women with a previous negative screening, that is, screening failure, during the first two screening rounds (1996-2002) and in the following rounds (2003-2008) in the Emilia-Romagna region. All cases of invasive cancers registered in the regional cancer registry between 1996 and 2008 were classified according to screening history through a record linkage with the screening programme registry. The incidence significantly decreased from 11.6/100 000 to 8.7/100 000; this decrease is due to a reduction in squamous cell cancers (annual percentage change -6.2; confidence interval: -7.8, -4.6) and advanced cancers (annual percentage change -6.6; confidence interval: -8.8, -4.3), whereas adenocarcinomas and microinvasive cancers were essentially stable. The proportion of cancers among women not yet invited and among nonresponders decreased over the two periods, from 45.5 to 33.3%. In contrast, the proportion of women with a previous negative Pap test less than 5 years and 5 years or more before cancer incidence increased from 5.7 to 13.3% and from 0.3 to 5.5%, respectively. Although nonattendance of the screening programme remains the main barrier to cervical cancer control, the introduction of a more sensitive test, such as the human papillomavirus DNA test, could significantly reduce the burden of disease.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Js] Journal subset:IM
[St] Status:In-Process
[do] DOI:10.1097/CEJ.0000000000000035

  3 / 1222 MEDLINE  
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[PMID]: 25763333
[Au] Autor:Monteiro JM; Monteiro GM; Caroli-Bottino A; Pannain VL
[Ad] Address:Postgraduate Program, Department of Pathology, University Hospital, Faculty of Medicine, Federal University of Rio de Janeiro, Avenida Prof. Rodolpho Paulo Rocco 255, Cidade Universitária, 21941-913 Rio de Janeiro, RJ, Brazil....
[Ti] Title:Nonalcoholic Fatty Liver Disease: Different Classifications Concordance and Relationship between Degrees of Morphological Features and Spectrum of the Disease.
[So] Source:Anal Cell Pathol (Amst);2014:526979, 2014.
[Is] ISSN:2210-7185
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The morphological features of nonalcoholic fatty liver disease (NAFLD) range from steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Liver biopsy remains the main tool for NASH diagnosis and many histological systems to diagnose and grade NAFLD were proposed. We evaluated the relationship among NAFLD activity score (NAS), histological diagnoses (non-NASH, possible NASH, and definite NASH), and histological algorithm proposed by Bedossa et al.; additionally the degrees of morphological features were semiquantified and correlated with non-NASH and NASH. Seventy-one liver biopsies were studied. The agreement among the three systems considering NASH and non-NASH was excellent (Κ = 0.96). Among the 22 biopsies with NAS 3-4, 72.7% showed to be NASH according to Bedossa's algorithm. The degree of steatosis, ballooning, lobular inflammation, and fibrosis stage were correlated with NASH (P < 0.001). Fibrosis stage 1 was also found in non-NASH. Over the spectrum of NAFLD, no association was observed between intensity of steatosis and fibrosis grade. The degrees of lobular inflammation showed association with fibrosis stage (P < 0.0001). In conclusion, there is agreement among different NAFLD classifications and NAS > 4 may be a better cutoff from which to consider NASH diagnosis; besides the highest degrees of steatosis, ballooning, inflammation, and fibrosis are associated with NASH.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Cu] Class update date: 150317
[Lr] Last revision date:150317
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1155/2014/526979

  4 / 1222 MEDLINE  
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[PMID]: 25568301
[Au] Autor:Caroli A; Prestia A; Galluzzi S; Ferrari C; van der Flier WM; Ossenkoppele R; Van Berckel B; Barkhof F; Teunissen C; Wall AE; Carter SF; Schöll M; Choo IH; Grimmer T; Redolfi A; Nordberg A; Scheltens P; Drzezga A; Frisoni GB; Alzheimer's Disease Neuroimaging Initiative
[Ad] Address:From the Medical Imaging Unit (A.C.), Biomedical Engineering Department, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Bergamo; LENITEM-Laboratory of Epidemiology Neuroimaging and Telemedicine (A.P., S.G., C.F., A.R., G.B.F.), IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Ital...
[Ti] Title:Mild cognitive impairment with suspected nonamyloid pathology (SNAP): Prediction of progression.
[So] Source:Neurology;84(5):508-15, 2015 Feb 3.
[Is] ISSN:1526-632X
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:OBJECTIVES: The aim of this study was to investigate predictors of progressive cognitive deterioration in patients with suspected non-Alzheimer disease pathology (SNAP) and mild cognitive impairment (MCI). METHODS: We measured markers of amyloid pathology (CSF ß-amyloid 42) and neurodegeneration (hippocampal volume on MRI and cortical metabolism on [(18)F]-fluorodeoxyglucose-PET) in 201 patients with MCI clinically followed for up to 6 years to detect progressive cognitive deterioration. We categorized patients with MCI as A+/A- and N+/N- based on presence/absence of amyloid pathology and neurodegeneration. SNAPs were A-N+ cases. RESULTS: The proportion of progressors was 11% (8/41), 34% (14/41), 56% (19/34), and 71% (60/85) in A-N-, A+N-, SNAP, and A+N+, respectively; the proportion of APOE ε4 carriers was 29%, 70%, 31%, and 71%, respectively, with the SNAP group featuring a significantly different proportion than both A+N- and A+N+ groups (p ≤ 0.005). Hypometabolism in SNAP patients was comparable to A+N+ patients (p = 0.154), while hippocampal atrophy was more severe in SNAP patients (p = 0.002). Compared with A-N-, SNAP and A+N+ patients had significant risk of progressive cognitive deterioration (hazard ratio = 2.7 and 3.8, p = 0.016 and p < 0.001), while A+N- patients did not (hazard ratio = 1.13, p = 0.771). In A+N- and A+N+ groups, none of the biomarkers predicted time to progression. In the SNAP group, lower time to progression was correlated with greater hypometabolism (r = 0.42, p = 0.073). CONCLUSIONS: Our findings support the notion that patients with SNAP MCI feature a specific risk progression profile.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Entry month:1502
[Cu] Class update date: 150226
[Lr] Last revision date:150226
[Js] Journal subset:AIM; IM
[St] Status:In-Process
[do] DOI:10.1212/WNL.0000000000001209

  5 / 1222 MEDLINE  
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[PMID]: 25433456
[Au] Autor:Micotti E; Paladini A; Balducci C; Tolomeo D; Frasca A; Marizzoni M; Filibian M; Caroli A; Valbusa G; Dix S; O'Neill M; Ozmen L; Czech C; Richardson JC; Frisoni GB; Forloni G
[Ad] Address:Neuroscience Department, IRCCS Istituto di Ricerche Farmacologiche "Mario Negri", Milano, Italy....
[Ti] Title:Striatum and entorhinal cortex atrophy in AD mouse models: MRI comprehensive analysis.
[So] Source:Neurobiol Aging;36(2):776-88, 2015 Feb.
[Is] ISSN:1558-1497
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Alzheimer's disease is experimentally modeled in transgenic (Tg) mice overexpressing mutated forms of the human amyloid precursor protein either alone or combined with mutated presenilins and tau. In the present study, we developed a systematic approach to compare double (TASTPM) and triple (APP/PS2/Tau) Tg mice by serial magnetic resonance imaging and spectroscopy analysis from 4 to 26 months of age to define homologous biomarkers between mice and humans. Hippocampal atrophy was found in Tg mice compared with WT. In APP/PS2/Tau the effect was age-dependent, whereas in TASTPM it was detectable from the first investigated time point. Importantly, both mice displayed an age-related entorhinal cortex thinning and robust striatal atrophy, the latter associated with a significant loss of synaptophysin. Hippocampal magnetic resonance spectroscopy revealed lower glutamate levels in both Tg mice and a selective myo-inositol increase in TASTPM. This noninvasive magnetic resonance imaging analysis, revealed common biomarkers between humans and mice, and could, thus, be promoted as a fully translational tool to be adopted in the preclinical investigation of therapeutic approaches.
[Pt] Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Entry month:1502
[Js] Journal subset:IM
[St] Status:In-Process

  6 / 1222 MEDLINE  
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[PMID]: 25518446
[Au] Autor:Circella E; Legretto M; Pugliese N; Caroli A; Bozzo G; Accogli G; Lavazza A; Camarda A
[Ti] Title:Psittacine beak and feather disease-like illness in Gouldian finches (Chloebia gouldiae).
[So] Source:Avian Dis;58(3):482-7, 2014 Sep.
[Is] ISSN:0005-2086
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:Beak and feather disease virus (BFDV) is a member of the genus Circovirus and causes psittacine beak and feather disease (PBFD) in Psittaciformes. PBFD is a severe disease generally characterized by immunodeficiency and beak and feather disorders. Although Circovirus spp. have been detected in several nonpsittacine species, little is known about the symptoms and the disease associated with this infection in birds other than Psittaciformes. In this study, we report the identification of Circovirus infection in a flock of Gouldian finches showing beak and feather disorders. Sequence analyses on the rep gene of the virus highlighted a strong similarity at nucleotide and amino acid levels with the corresponding regions of BFDV from psittacine species. By contrast, it was more distant to circoviruses identified in finch and canary.
[Mh] MeSH terms primary: Beak/virology
Bird Diseases/virology
Circoviridae Infections/veterinary
Circovirus/isolation & purification
Feathers/virology
[Mh] MeSH terms secundary: Animals
Circoviridae Infections/virology
Circovirus/classification
Circovirus/genetics
Circovirus/physiology
Female
Male
Molecular Sequence Data
Phylogeny
[Pt] Publication type:CASE REPORTS; JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[Da] Date of entry for processing:141218
[St] Status:MEDLINE

  7 / 1222 MEDLINE  
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[PMID]: 25696953
[Au] Autor:Luzina EV; Mitin NA; Pogrebniakov VIu; Fedorova LV
[Ti] Title:[Caroli's disease: diagnostic problems and possibilities of treatment].
[So] Source:Klin Med (Mosk);91(10):57-60, 2013.
[Is] ISSN:0023-2149
[Cp] Country of publication:Russia (Federation)
[La] Language:rus
[Ab] Abstract:Caroli's disease is a rare congenital condition characterized by segmental non-obstructive fibrocystic dilation of intrahepatic bile ducts. Dilated ducts may be infected and contain stones. This review of the modern literature describes few known cases of the disease, analyses its clinical features and results of treatment. The principal diagnostic methods include visualization by ultrasound study, CT, MRT, retrograde and transhepatic cholangiography. Surgical intervention is the method of choice for the treatment of the disease including resection of liver, placement of hepatico-jejunal anastomoses and transplantation. The choice depends on the extent of the lesion and anticipated complications. The authors' observation of the patient with Caroli's disease in a 35 year-old woman is presented. It was successfully treated by left-hand bisegmentectomy even though the disease was diagnosed 14 years after the first symptoms. It is recommended that the disease, even if a rare one, should be included in the algorithm of differential diagnostics ofrecurrent abdominal pain with manifestations of cholestasis or fever of an unknown origin.
[Mh] MeSH terms primary: Caroli Disease/diagnosis
[Mh] MeSH terms secundary: Adult
Caroli Disease/surgery
Female
Humans
[Pt] Publication type:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[Da] Date of entry for processing:150220
[St] Status:MEDLINE

  8 / 1222 MEDLINE  
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[PMID]: 25447106
[Au] Autor:Obusez EC; Udayasankar U
[Ad] Address:Imaging Institute, Cleveland Clinic Children's Hospital, Cleveland, Ohio.
[Ti] Title:Autosomal recessive polycystic kidney disease with caroli syndrome.
[So] Source:J Urol;193(2):679-80, 2015 Feb.
[Is] ISSN:1527-3792
[Cp] Country of publication:United States
[La] Language:eng
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1501
[Js] Journal subset:AIM; IM
[St] Status:In-Process

  9 / 1222 MEDLINE  
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[PMID]: 25600951
[Au] Autor:Zhao L; Hosseini M; Wilcox R; Liu Q; Crook T; Taxy JB; Ferrell L; Hart J
[Ad] Address:Department of Pathology, University of Chicago, Chicago, IL 60637. Electronic address: lei.zhao@uchospitals.edu....
[Ti] Title:Segmental cholangiectasia clinically worrisome for cholangiocarcinoma: comparison with recurrent pyogenic cholangitis.
[So] Source:Hum Pathol;46(3):426-33, 2015 Mar.
[Is] ISSN:1532-8392
[Cp] Country of publication:United States
[La] Language:eng
[Ab] Abstract:The aim of this study was to review the clinical, radiographic, and pathologic features of cases of benign segmental cholangiectasia in non-Asian US patients with clinical concern for cholangiocarcinoma and compare these features with cases of recurrent pyogenic cholangitis (RPC) in Asian patients. A total of 10 non-Asian US patients with benign segmental cholangiectasia were included in this study. Nine of them underwent partial hepatic resection due to cholangiographic findings of segmental cholangiectasia with mural thickening and/or proximal biliary stricture. One was found to have markedly dilated and thickened intrahepatic bile ducts at the time of autopsy. Clinical and radiographic findings were reviewed. Elastin stains and immunostains for immunoglobulin G4, cluster of differentiation (CD1a), and Langerin were performed. Six comparison cases of RPC in Asian US patients were also examined. Histologic examination of resection specimens revealed markedly dilated large intrahepatic bile ducts with variable degrees of mural fibrosis, periductal gland hyperplasia, inflammation, and liver parenchymal atrophy. These changes were not associated with a ductular reaction. There was no evidence of biliary dysplasia or biliary cirrhosis in any cases. No gross or microscopic feature definitively separated the Asian from non-Asian patients. The etiology of this disorder in non-Asian US patients is unclear. It does not appear to represent a localized variant of Caroli disease or primary sclerosing cholangitis. The high degree of similarity shared by these cases and classic RPC suggests a common pathogenic mechanism, although the pathologic features tend to be less well developed in the cases from the non-Asian US patients.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1503
[Js] Journal subset:IM
[St] Status:In-Data-Review

  10 / 1222 MEDLINE  
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[PMID]: 25327281
[Au] Autor:Wang ZX; Li YG; Wang RL; Li YW; Li ZY; Wang LF; Yang HY; Zhu Y; Wang Y; Bai YF; He TT; Zhang XF; Xiao XH
[Ad] Address:Department of Graduate School, 301 Hospital, Beijing, China; Integrative Medical Centre, 302 Hospital, Beijing, China.
[Ti] Title:Clinical classification of Caroli's disease: an analysis of 30 patients.
[So] Source:HPB (Oxford);17(3):278-83, 2015 Mar.
[Is] ISSN:1477-2574
[Cp] Country of publication:England
[La] Language:eng
[Ab] Abstract:BACKGROUND: Caroli's disease (CD) is a rare congenital disorder. The early diagnosis of the disease and differentiation of types I and II are of extreme importance to patient survival. This study was designed to review and discuss observations in 30 patients with CD and to clarify the clinical characteristics of the disease. METHODS: The demographic and clinical features, laboratory indicators, imaging findings and pathology results for 30 patients with CD were reviewed retrospectively. RESULTS: Caroli's disease can occur at any age. The average age of onset in the study cohort was 24 years. Patients who presented with symptoms before the age of 40 years were more likely to develop type II CD. Approximately one-third of patients presented without positive signs at original diagnosis and most of these patients were found to have type I CD on pathology. Anaemia, leucopoenia and thrombocytopoenia were more frequent in patients with type II than type I CD. Magnetic resonance cholangiopancreatography (MRCP) and computed tomography (CT) examinations were most useful in diagnosing CD. CONCLUSIONS: No typical symptoms, signs or laboratory indicators are able to distinguish CD from other conditions. Both MRCP and CT were most valuable in diagnosis. The two types of CD may be differentiated by age of onset and routine blood tests.
[Pt] Publication type:JOURNAL ARTICLE
[Em] Entry month:1502
[Cu] Class update date: 150304
[Lr] Last revision date:150304
[Js] Journal subset:IM
[St] Status:In-Data-Review
[do] DOI:10.1111/hpb.12330


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